TY  - JOUR
AU  - Pajović, Snežana B.
AU  - Saičić, Zorica S.
AU  - Spasić, Mihajlo
AU  - Petrović, Vojislav M.
PY  - 2003
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/2628
AB  - The brain is widely responsive to gonadal hormones. The functional significance of ovarian hormones in the brain is evident from biochemical studies indicating that estradiol or progesterone treatment of testectomized rats produces changes of antioxidant enzyme activities. The effect of estradiol benzoate (EB) and progesterone (P) in the control of antioxidant (AO) enzyme activities was studied in the brain of adult male Wistar rats. The activities of catalase (CAT), glutathione peroxidase (GSH-Px), glutathione-S-transferase (GST) and glutathione reductase (GR) were measured in appropriate subcellular fractions, prepared from brains of animals belonging to various experimental groups. These groups were designed with the intention to follow changes in enzyme activities 2 h or 24 h after systemic administration of 5 mug EB or 2 mg P to testectomized (TX) animals. The obtained results show that both EB and P increase CAT activity, whereas EB decreases GSH-Px, GST and GR activities. These findings clearly show the modulatory role of EB and P in the control of enzymes responsible for the protection of rat nerve cells against oxidative damage caused by free oxygen radicals.
T2  - Physiological Research
T1  - The effect of ovarian hormones on antioxidant enzyme activities in the brain of male rats
VL  - 52
IS  - 2
SP  - 189
EP  - 194
UR  - https://hdl.handle.net/21.15107/rcub_vinar_2628
ER  - 

@article{
author = "Pajović, Snežana B. and Saičić, Zorica S. and Spasić, Mihajlo and Petrović, Vojislav M.",
year = "2003",
abstract = "The brain is widely responsive to gonadal hormones. The functional significance of ovarian hormones in the brain is evident from biochemical studies indicating that estradiol or progesterone treatment of testectomized rats produces changes of antioxidant enzyme activities. The effect of estradiol benzoate (EB) and progesterone (P) in the control of antioxidant (AO) enzyme activities was studied in the brain of adult male Wistar rats. The activities of catalase (CAT), glutathione peroxidase (GSH-Px), glutathione-S-transferase (GST) and glutathione reductase (GR) were measured in appropriate subcellular fractions, prepared from brains of animals belonging to various experimental groups. These groups were designed with the intention to follow changes in enzyme activities 2 h or 24 h after systemic administration of 5 mug EB or 2 mg P to testectomized (TX) animals. The obtained results show that both EB and P increase CAT activity, whereas EB decreases GSH-Px, GST and GR activities. These findings clearly show the modulatory role of EB and P in the control of enzymes responsible for the protection of rat nerve cells against oxidative damage caused by free oxygen radicals.",
journal = "Physiological Research",
title = "The effect of ovarian hormones on antioxidant enzyme activities in the brain of male rats",
volume = "52",
number = "2",
pages = "189-194",
url = "https://hdl.handle.net/21.15107/rcub_vinar_2628"
}

Pajović, S. B., Saičić, Z. S., Spasić, M.,& Petrović, V. M.. (2003). The effect of ovarian hormones on antioxidant enzyme activities in the brain of male rats. in Physiological Research, 52(2), 189-194.
https://hdl.handle.net/21.15107/rcub_vinar_2628

Pajović SB, Saičić ZS, Spasić M, Petrović VM. The effect of ovarian hormones on antioxidant enzyme activities in the brain of male rats. in Physiological Research. 2003;52(2):189-194.
https://hdl.handle.net/21.15107/rcub_vinar_2628 .

Pajović, Snežana B., Saičić, Zorica S., Spasić, Mihajlo, Petrović, Vojislav M., "The effect of ovarian hormones on antioxidant enzyme activities in the brain of male rats" in Physiological Research, 52, no. 2 (2003):189-194,
https://hdl.handle.net/21.15107/rcub_vinar_2628 .

TY  - JOUR
AU  - Pajović, Snežana B.
AU  - Saičić, Zorica S.
AU  - Spasić, Mihajlo
AU  - Petrović, Vojislav M.
AU  - Martinović, Jelena
PY  - 1999
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/2251
AB  - The activities of glutathione dependent antioxidant enzymes were measured in subcellular fractions of whole brain homogenates prepared from ovariectomized (OVX) female rats, untreated or treated 2 h or 24 h prior to sacrifice with a single dose of 2 mg progesterone (P) or 5 mu g estradiol benzoate (EB). Glutathione peroxidase (GSH-Px) activity was not changed following systemic administration of EB, but P increased GSH-Px in the brain of OVX rats 24 h after the treatment. The activity of glutathione reductase (GR) was suppressed by EB short time, only 2 h following treatment, whereas P increased the enzyme activity 24 h after treatment. On the other hand, the activities of catalase (CAT) and glutathione-S-transferase (GST) were not changed following systemic administration of EB or P. The present work was carried out to study the involvement of ovarian steroids, especially P, in the control of GSH-Px and GR activities, and our results suggest that oxidative stress in the brain of female rats may be modulated by the level of progesterone.
T2  - General Physiology and Biophysics
T1  - Effects of progesterone and estradiol benzoate on glutathione dependent antioxidant enzyme activities in the brain of female rats
VL  - 18
IS  - 1
SP  - 35
EP  - 44
UR  - https://hdl.handle.net/21.15107/rcub_vinar_2251
ER  - 

@article{
author = "Pajović, Snežana B. and Saičić, Zorica S. and Spasić, Mihajlo and Petrović, Vojislav M. and Martinović, Jelena",
year = "1999",
abstract = "The activities of glutathione dependent antioxidant enzymes were measured in subcellular fractions of whole brain homogenates prepared from ovariectomized (OVX) female rats, untreated or treated 2 h or 24 h prior to sacrifice with a single dose of 2 mg progesterone (P) or 5 mu g estradiol benzoate (EB). Glutathione peroxidase (GSH-Px) activity was not changed following systemic administration of EB, but P increased GSH-Px in the brain of OVX rats 24 h after the treatment. The activity of glutathione reductase (GR) was suppressed by EB short time, only 2 h following treatment, whereas P increased the enzyme activity 24 h after treatment. On the other hand, the activities of catalase (CAT) and glutathione-S-transferase (GST) were not changed following systemic administration of EB or P. The present work was carried out to study the involvement of ovarian steroids, especially P, in the control of GSH-Px and GR activities, and our results suggest that oxidative stress in the brain of female rats may be modulated by the level of progesterone.",
journal = "General Physiology and Biophysics",
title = "Effects of progesterone and estradiol benzoate on glutathione dependent antioxidant enzyme activities in the brain of female rats",
volume = "18",
number = "1",
pages = "35-44",
url = "https://hdl.handle.net/21.15107/rcub_vinar_2251"
}

Pajović, S. B., Saičić, Z. S., Spasić, M., Petrović, V. M.,& Martinović, J.. (1999). Effects of progesterone and estradiol benzoate on glutathione dependent antioxidant enzyme activities in the brain of female rats. in General Physiology and Biophysics, 18(1), 35-44.
https://hdl.handle.net/21.15107/rcub_vinar_2251

Pajović SB, Saičić ZS, Spasić M, Petrović VM, Martinović J. Effects of progesterone and estradiol benzoate on glutathione dependent antioxidant enzyme activities in the brain of female rats. in General Physiology and Biophysics. 1999;18(1):35-44.
https://hdl.handle.net/21.15107/rcub_vinar_2251 .

Pajović, Snežana B., Saičić, Zorica S., Spasić, Mihajlo, Petrović, Vojislav M., Martinović, Jelena, "Effects of progesterone and estradiol benzoate on glutathione dependent antioxidant enzyme activities in the brain of female rats" in General Physiology and Biophysics, 18, no. 1 (1999):35-44,
https://hdl.handle.net/21.15107/rcub_vinar_2251 .

TY  - JOUR
AU  - Saičić, Zorica S.
AU  - Pajović, Snežana B.
AU  - Korać, Bato
AU  - Spasić, Mihajlo
AU  - Martinović, Jelena
AU  - Petrović, Vojislav M.
PY  - 1998
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/2120
AB  - Enzymatic activities of glutathione peroxidase, glutathione-S-transferase, glutathione reductase and catalase, as well as the glutathione content were measured in the brain tissue of regularly cycling rats at dioestrus, proestrus and estrus. The activity of glutathione peroxidase was found to be suppressed at proestrus, whereas that of catalase was increased at dioestrus. Glutathione transferase and glutathione reductase activities, as well as the glutathione content appeared to be stable during the oestrous cycle. These results suggest that, in the female rat, glutathione peroxidase and catalase activities in the brain tissue are influenced by the ovarian hormone status.
T2  - Physiological Research
T1  - Glutathione-dependent antioxidant enzyme activities and glutathione content in the rat brain at different stages of oestrous cycle
VL  - 47
IS  - 1
SP  - 61
EP  - 66
UR  - https://hdl.handle.net/21.15107/rcub_vinar_2120
ER  - 

@article{
author = "Saičić, Zorica S. and Pajović, Snežana B. and Korać, Bato and Spasić, Mihajlo and Martinović, Jelena and Petrović, Vojislav M.",
year = "1998",
abstract = "Enzymatic activities of glutathione peroxidase, glutathione-S-transferase, glutathione reductase and catalase, as well as the glutathione content were measured in the brain tissue of regularly cycling rats at dioestrus, proestrus and estrus. The activity of glutathione peroxidase was found to be suppressed at proestrus, whereas that of catalase was increased at dioestrus. Glutathione transferase and glutathione reductase activities, as well as the glutathione content appeared to be stable during the oestrous cycle. These results suggest that, in the female rat, glutathione peroxidase and catalase activities in the brain tissue are influenced by the ovarian hormone status.",
journal = "Physiological Research",
title = "Glutathione-dependent antioxidant enzyme activities and glutathione content in the rat brain at different stages of oestrous cycle",
volume = "47",
number = "1",
pages = "61-66",
url = "https://hdl.handle.net/21.15107/rcub_vinar_2120"
}

Saičić, Z. S., Pajović, S. B., Korać, B., Spasić, M., Martinović, J.,& Petrović, V. M.. (1998). Glutathione-dependent antioxidant enzyme activities and glutathione content in the rat brain at different stages of oestrous cycle. in Physiological Research, 47(1), 61-66.
https://hdl.handle.net/21.15107/rcub_vinar_2120

Saičić ZS, Pajović SB, Korać B, Spasić M, Martinović J, Petrović VM. Glutathione-dependent antioxidant enzyme activities and glutathione content in the rat brain at different stages of oestrous cycle. in Physiological Research. 1998;47(1):61-66.
https://hdl.handle.net/21.15107/rcub_vinar_2120 .

Saičić, Zorica S., Pajović, Snežana B., Korać, Bato, Spasić, Mihajlo, Martinović, Jelena, Petrović, Vojislav M., "Glutathione-dependent antioxidant enzyme activities and glutathione content in the rat brain at different stages of oestrous cycle" in Physiological Research, 47, no. 1 (1998):61-66,
https://hdl.handle.net/21.15107/rcub_vinar_2120 .

TY  - JOUR
AU  - Pajović, Snežana B.
AU  - Saičić, Zorica S.
AU  - Spasić, Mihajlo
AU  - Petrović, Vojislav M.
AU  - Martinović, Jelena
PY  - 1996
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/1969
AB  - The activities of mitochondrial, manganese-containing superoxide dismutase (MnSOD) and cytoplasmic, copper-zinc-containing superoxide dismutase (CuZnSOD) were measured in subcellular fractions of whole brain homogenates prepared from intact and gonadectomized (GDX) male rats, untreated or treated subcutaneously (sc) with a single dose of 2 mg progesterone (P) and/or 5 mu g estradiol benzoate (EB). Neither MnSOD nor CuZnSOD was affected by the removal of the testes. Similarly, CuZnSOD activity was steady following systemic administration of P and/or EB to intact and GDX animals 2 h or 24 h prior to sacrifice. On the other hand, both P and EB suppressed MnSOD in the brain of either intact or GDX rats. These results suggest involvement of P and EB in the control of MnSOD activity in the brain of male rats.
T2  - Experientia
T1  - Effects of progesterone and estradiol benzoate on superoxide dismutase activity in the brain of male rats
VL  - 52
IS  - 3
SP  - 221
EP  - 224
DO  - 10.1007/BF01920710
UR  - https://hdl.handle.net/21.15107/rcub_vinar_1969
ER  - 

@article{
author = "Pajović, Snežana B. and Saičić, Zorica S. and Spasić, Mihajlo and Petrović, Vojislav M. and Martinović, Jelena",
year = "1996",
abstract = "The activities of mitochondrial, manganese-containing superoxide dismutase (MnSOD) and cytoplasmic, copper-zinc-containing superoxide dismutase (CuZnSOD) were measured in subcellular fractions of whole brain homogenates prepared from intact and gonadectomized (GDX) male rats, untreated or treated subcutaneously (sc) with a single dose of 2 mg progesterone (P) and/or 5 mu g estradiol benzoate (EB). Neither MnSOD nor CuZnSOD was affected by the removal of the testes. Similarly, CuZnSOD activity was steady following systemic administration of P and/or EB to intact and GDX animals 2 h or 24 h prior to sacrifice. On the other hand, both P and EB suppressed MnSOD in the brain of either intact or GDX rats. These results suggest involvement of P and EB in the control of MnSOD activity in the brain of male rats.",
journal = "Experientia",
title = "Effects of progesterone and estradiol benzoate on superoxide dismutase activity in the brain of male rats",
volume = "52",
number = "3",
pages = "221-224",
doi = "10.1007/BF01920710",
url = "https://hdl.handle.net/21.15107/rcub_vinar_1969"
}

Pajović, S. B., Saičić, Z. S., Spasić, M., Petrović, V. M.,& Martinović, J.. (1996). Effects of progesterone and estradiol benzoate on superoxide dismutase activity in the brain of male rats. in Experientia, 52(3), 221-224.
https://doi.org/10.1007/BF01920710
https://hdl.handle.net/21.15107/rcub_vinar_1969

Pajović SB, Saičić ZS, Spasić M, Petrović VM, Martinović J. Effects of progesterone and estradiol benzoate on superoxide dismutase activity in the brain of male rats. in Experientia. 1996;52(3):221-224.
doi:10.1007/BF01920710
https://hdl.handle.net/21.15107/rcub_vinar_1969 .

Pajović, Snežana B., Saičić, Zorica S., Spasić, Mihajlo, Petrović, Vojislav M., Martinović, Jelena, "Effects of progesterone and estradiol benzoate on superoxide dismutase activity in the brain of male rats" in Experientia, 52, no. 3 (1996):221-224,
https://doi.org/10.1007/BF01920710 .,
https://hdl.handle.net/21.15107/rcub_vinar_1969 .