TY  - JOUR
AU  - Baralic, Ivana
AU  - Anđelković, Marija
AU  - Đorđević, Brižita
AU  - Dikic, Nenad
AU  - Radivojevic, Nenad
AU  - Suzin-Zivkovic, Violeta
AU  - Radojević-Škodrić, Sanja
AU  - Pejić, Snežana
PY  - 2015
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/639
AB  - The physiologic stress induced by physical activity is reflected in immune systemperturbations, oxidative stress, muscle injury, and inflammation. We investigated the effect of astaxanthin (Asx) supplementation on salivary IgA (sIgA) and oxidative stress status in plasma, along with changes in biochemical parameters and total/differential white cell counts. Forty trained male soccer players were randomly assigned to Asx and placebo groups. Asx group was supplemented with 4mg of Asx. Saliva and blood samples were collected at the baseline and after 90 days of supplementation in preexercise conditions. We observed a rise of sIgA levels at rest after 90 days of Asx supplementation, which was accompanied with a decrease in prooxidant-antioxidant balance. The plasma muscle enzymes levels were reduced significantly by Asx supplementation and by regular training. The increase in neutrophil count and hs-CRP level was found only in placebo group, indicating a significant blunting of the systemic inflammatory response in the subjects taking Asx. This study indicates that Asx supplementation improves sIgA response and attenuates muscle damage, thus preventing inflammation induced by rigorous physical training. Our findings also point that Asx could show significant physiologic modulation in individuals with mucosal immunity impairment or under conditions of increased oxidative stress and inflammation.
T2  - Evidence-based Complementary and Alternative Medicine / eCAM
T1  - Effect of Astaxanthin Supplementation on Salivary IgA, Oxidative Stress, and Inflammation in Young Soccer Players
DO  - 10.1155/2015/783761
ER  - 

@article{
author = "Baralic, Ivana and Anđelković, Marija and Đorđević, Brižita and Dikic, Nenad and Radivojevic, Nenad and Suzin-Zivkovic, Violeta and Radojević-Škodrić, Sanja and Pejić, Snežana",
year = "2015",
abstract = "The physiologic stress induced by physical activity is reflected in immune systemperturbations, oxidative stress, muscle injury, and inflammation. We investigated the effect of astaxanthin (Asx) supplementation on salivary IgA (sIgA) and oxidative stress status in plasma, along with changes in biochemical parameters and total/differential white cell counts. Forty trained male soccer players were randomly assigned to Asx and placebo groups. Asx group was supplemented with 4mg of Asx. Saliva and blood samples were collected at the baseline and after 90 days of supplementation in preexercise conditions. We observed a rise of sIgA levels at rest after 90 days of Asx supplementation, which was accompanied with a decrease in prooxidant-antioxidant balance. The plasma muscle enzymes levels were reduced significantly by Asx supplementation and by regular training. The increase in neutrophil count and hs-CRP level was found only in placebo group, indicating a significant blunting of the systemic inflammatory response in the subjects taking Asx. This study indicates that Asx supplementation improves sIgA response and attenuates muscle damage, thus preventing inflammation induced by rigorous physical training. Our findings also point that Asx could show significant physiologic modulation in individuals with mucosal immunity impairment or under conditions of increased oxidative stress and inflammation.",
journal = "Evidence-based Complementary and Alternative Medicine / eCAM",
title = "Effect of Astaxanthin Supplementation on Salivary IgA, Oxidative Stress, and Inflammation in Young Soccer Players",
doi = "10.1155/2015/783761"
}

Baralic, I., Anđelković, M., Đorđević, B., Dikic, N., Radivojevic, N., Suzin-Zivkovic, V., Radojević-Škodrić, S.,& Pejić, S.. (2015). Effect of Astaxanthin Supplementation on Salivary IgA, Oxidative Stress, and Inflammation in Young Soccer Players. in Evidence-based Complementary and Alternative Medicine / eCAM.
https://doi.org/10.1155/2015/783761

Baralic I, Anđelković M, Đorđević B, Dikic N, Radivojevic N, Suzin-Zivkovic V, Radojević-Škodrić S, Pejić S. Effect of Astaxanthin Supplementation on Salivary IgA, Oxidative Stress, and Inflammation in Young Soccer Players. in Evidence-based Complementary and Alternative Medicine / eCAM. 2015;.
doi:10.1155/2015/783761 .

Baralic, Ivana, Anđelković, Marija, Đorđević, Brižita, Dikic, Nenad, Radivojevic, Nenad, Suzin-Zivkovic, Violeta, Radojević-Škodrić, Sanja, Pejić, Snežana, "Effect of Astaxanthin Supplementation on Salivary IgA, Oxidative Stress, and Inflammation in Young Soccer Players" in Evidence-based Complementary and Alternative Medicine / eCAM (2015),
https://doi.org/10.1155/2015/783761 . .

TY  - JOUR
AU  - Baralic, Ivana
AU  - Đorđević, Brižita
AU  - Dikic, Nenad
AU  - Kotur-Stevuljevic, Jelena
AU  - Spasic, Slavica
AU  - Jelić-Ivanović, Zorana
AU  - Radivojevic, Nenad
AU  - Anđelković, Marija
AU  - Pejić, Snežana
PY  - 2013
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/5713
AB  - The purpose of the study was to examine the effects of astaxanthin (Asx) on paraoxonase (PON1) activities and oxidative stress status in soccer players. Forty soccer players were randomly assigned in a double-blind fashion to Asx and placebo (P) group. Blood samples were obtained before, 45 and 90days after supplementation. PON1 activity was assessed by using two substrates: paraoxon and diazoxon. The oxidative stress biomarkers were also examined: total sulphydryl group content (-SH groups), thiobarbituric acid-reactive substances (TBARS), advanced oxidation protein products and redox balance. The significant interaction effect of supplementation and training (p LT 0.05) on PON1 activity toward paraoxon was observed. The PON1 activity toward diazoxon increased in Asx group after 90days (p LT 0.01), while there was no significant difference in P group. SH groups content rose from pre- to post-supplementation period only in Asx group (supplementation and training, p LT 0.05; training, p LT 0.01). TBARS levels decreased after 45days and increased after 90days of regular soccer training in both groups (training, p LT 0.001). Redox balance decreased significantly in response to the regular training, regardless of treatment group (training, p LT 0.001). Asx supplementation might increase total SH groups content and improve PON1 activity through protection of free thiol groups against oxidative modification. Copyright (c) 2012 John Wiley and Sons, Ltd.
T2  - Phytotherapy Research
T1  - Effect of Astaxanthin Supplementation on Paraoxonase 1 Activities and Oxidative Stress Status in Young Soccer Players
VL  - 27
IS  - 10
SP  - 1536
EP  - 1542
DO  - 10.1002/ptr.4898
ER  - 

@article{
author = "Baralic, Ivana and Đorđević, Brižita and Dikic, Nenad and Kotur-Stevuljevic, Jelena and Spasic, Slavica and Jelić-Ivanović, Zorana and Radivojevic, Nenad and Anđelković, Marija and Pejić, Snežana",
year = "2013",
abstract = "The purpose of the study was to examine the effects of astaxanthin (Asx) on paraoxonase (PON1) activities and oxidative stress status in soccer players. Forty soccer players were randomly assigned in a double-blind fashion to Asx and placebo (P) group. Blood samples were obtained before, 45 and 90days after supplementation. PON1 activity was assessed by using two substrates: paraoxon and diazoxon. The oxidative stress biomarkers were also examined: total sulphydryl group content (-SH groups), thiobarbituric acid-reactive substances (TBARS), advanced oxidation protein products and redox balance. The significant interaction effect of supplementation and training (p LT 0.05) on PON1 activity toward paraoxon was observed. The PON1 activity toward diazoxon increased in Asx group after 90days (p LT 0.01), while there was no significant difference in P group. SH groups content rose from pre- to post-supplementation period only in Asx group (supplementation and training, p LT 0.05; training, p LT 0.01). TBARS levels decreased after 45days and increased after 90days of regular soccer training in both groups (training, p LT 0.001). Redox balance decreased significantly in response to the regular training, regardless of treatment group (training, p LT 0.001). Asx supplementation might increase total SH groups content and improve PON1 activity through protection of free thiol groups against oxidative modification. Copyright (c) 2012 John Wiley and Sons, Ltd.",
journal = "Phytotherapy Research",
title = "Effect of Astaxanthin Supplementation on Paraoxonase 1 Activities and Oxidative Stress Status in Young Soccer Players",
volume = "27",
number = "10",
pages = "1536-1542",
doi = "10.1002/ptr.4898"
}

Baralic, I., Đorđević, B., Dikic, N., Kotur-Stevuljevic, J., Spasic, S., Jelić-Ivanović, Z., Radivojevic, N., Anđelković, M.,& Pejić, S.. (2013). Effect of Astaxanthin Supplementation on Paraoxonase 1 Activities and Oxidative Stress Status in Young Soccer Players. in Phytotherapy Research, 27(10), 1536-1542.
https://doi.org/10.1002/ptr.4898

Baralic I, Đorđević B, Dikic N, Kotur-Stevuljevic J, Spasic S, Jelić-Ivanović Z, Radivojevic N, Anđelković M, Pejić S. Effect of Astaxanthin Supplementation on Paraoxonase 1 Activities and Oxidative Stress Status in Young Soccer Players. in Phytotherapy Research. 2013;27(10):1536-1542.
doi:10.1002/ptr.4898 .

Baralic, Ivana, Đorđević, Brižita, Dikic, Nenad, Kotur-Stevuljevic, Jelena, Spasic, Slavica, Jelić-Ivanović, Zorana, Radivojevic, Nenad, Anđelković, Marija, Pejić, Snežana, "Effect of Astaxanthin Supplementation on Paraoxonase 1 Activities and Oxidative Stress Status in Young Soccer Players" in Phytotherapy Research, 27, no. 10 (2013):1536-1542,
https://doi.org/10.1002/ptr.4898 . .