TY  - JOUR
AU  - Brborić, Jasmina
AU  - Jovanovic, M. S.
AU  - Vranješ-Đurić, Sanja
AU  - Čudina, Olivera
AU  - Marković, Bojan D.
AU  - Vladimirov, Sote
PY  - 2013
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/5394
AB  - The partition coefficients (log P) of theoretically possible alkyliodinated iminodiacetic acid (IDA) derivatives and commercial IDA derivatives were calculated using two computer programs: ChemSketch Log P and ChemOffice Ultra. Newly synthesized ligands (DIETHYLIODIDA and DIISOPROPYLIODIDA) with the highest calculated log P were labeled with technetium-99m. The biodistribution and the influence of bilirubin on their biokinetics were investigated in rats and compared to corresponding results for commercial Tc-99m-BROMIDA. Log P of Tc-99m-complexes of synthesized ligands were determined experimentally as well as the protein binding. In comparison to Tc-99m-BROMIDA, Tc-99m-DIETHYLIODIDA has: (a) better biliary excretion (2.76 +/- 0.15%ID/g versus 1.83 +/- 0.10%ID/g); (b) faster hepatic clearance (2.90 +/- 0.21%ID/g versus 7.47 +/- 0.70%ID/g) and decreased biliary excretion (for 14% versus 22%) in conditions of hyperbilirubinemia after 15 min. It is proved that Tc-99m-DIISOPROPYLIODIDA has a prolonged hepatic transit time and decreased biliary excretion. (c) 2012 Elsevier Ltd. All rights reserved.
T2  - Applied Radiation and Isotopes
T1  - The effect of lipophilicity on the hepatobiliary properties of iminodiacetic acid derivatives in the conditions of hyperbilirubinemia
VL  - 74
SP  - 31
EP  - 35
DO  - 10.1016/j.apradiso.2012.12.014
ER  - 

@article{
author = "Brborić, Jasmina and Jovanovic, M. S. and Vranješ-Đurić, Sanja and Čudina, Olivera and Marković, Bojan D. and Vladimirov, Sote",
year = "2013",
abstract = "The partition coefficients (log P) of theoretically possible alkyliodinated iminodiacetic acid (IDA) derivatives and commercial IDA derivatives were calculated using two computer programs: ChemSketch Log P and ChemOffice Ultra. Newly synthesized ligands (DIETHYLIODIDA and DIISOPROPYLIODIDA) with the highest calculated log P were labeled with technetium-99m. The biodistribution and the influence of bilirubin on their biokinetics were investigated in rats and compared to corresponding results for commercial Tc-99m-BROMIDA. Log P of Tc-99m-complexes of synthesized ligands were determined experimentally as well as the protein binding. In comparison to Tc-99m-BROMIDA, Tc-99m-DIETHYLIODIDA has: (a) better biliary excretion (2.76 +/- 0.15%ID/g versus 1.83 +/- 0.10%ID/g); (b) faster hepatic clearance (2.90 +/- 0.21%ID/g versus 7.47 +/- 0.70%ID/g) and decreased biliary excretion (for 14% versus 22%) in conditions of hyperbilirubinemia after 15 min. It is proved that Tc-99m-DIISOPROPYLIODIDA has a prolonged hepatic transit time and decreased biliary excretion. (c) 2012 Elsevier Ltd. All rights reserved.",
journal = "Applied Radiation and Isotopes",
title = "The effect of lipophilicity on the hepatobiliary properties of iminodiacetic acid derivatives in the conditions of hyperbilirubinemia",
volume = "74",
pages = "31-35",
doi = "10.1016/j.apradiso.2012.12.014"
}

Brborić, J., Jovanovic, M. S., Vranješ-Đurić, S., Čudina, O., Marković, B. D.,& Vladimirov, S.. (2013). The effect of lipophilicity on the hepatobiliary properties of iminodiacetic acid derivatives in the conditions of hyperbilirubinemia. in Applied Radiation and Isotopes, 74, 31-35.
https://doi.org/10.1016/j.apradiso.2012.12.014

Brborić J, Jovanovic MS, Vranješ-Đurić S, Čudina O, Marković BD, Vladimirov S. The effect of lipophilicity on the hepatobiliary properties of iminodiacetic acid derivatives in the conditions of hyperbilirubinemia. in Applied Radiation and Isotopes. 2013;74:31-35.
doi:10.1016/j.apradiso.2012.12.014 .

Brborić, Jasmina, Jovanovic, M. S., Vranješ-Đurić, Sanja, Čudina, Olivera, Marković, Bojan D., Vladimirov, Sote, "The effect of lipophilicity on the hepatobiliary properties of iminodiacetic acid derivatives in the conditions of hyperbilirubinemia" in Applied Radiation and Isotopes, 74 (2013):31-35,
https://doi.org/10.1016/j.apradiso.2012.12.014 . .

TY  - CONF
AU  - Čudina, Olivera
AU  - Janković, Ivana A.
AU  - Brborić, Jasmina
AU  - Karljiković-Rajić, Katarina
AU  - Vladimirov, Sote
PY  - 2008
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/9370
AB  - The interaction of valsartan (VAL), an angiotensin II receptor antagonist, with cationic surfactant cetyltrimethylammonium bromide (CTAB) was investigated. To quantify the degree of VAL/CTAB interactions, two constants were calculated by using mathematical models: micelle/water partition coefficient and drug/micelle binding constant.
PB  - Society of Physical Chemists of Serbia
C3  - Physical chemistry 2008 : 9th international conference on fundamental and applied aspects of physical chemistry
T1  - Study of valsartan interaction with micelles as a model system for biomembrane
VL  - 1
SP  - 366
EP  - 368
UR  - https://hdl.handle.net/21.15107/rcub_vinar_9370
ER  - 

@conference{
author = "Čudina, Olivera and Janković, Ivana A. and Brborić, Jasmina and Karljiković-Rajić, Katarina and Vladimirov, Sote",
year = "2008",
abstract = "The interaction of valsartan (VAL), an angiotensin II receptor antagonist, with cationic surfactant cetyltrimethylammonium bromide (CTAB) was investigated. To quantify the degree of VAL/CTAB interactions, two constants were calculated by using mathematical models: micelle/water partition coefficient and drug/micelle binding constant.",
publisher = "Society of Physical Chemists of Serbia",
journal = "Physical chemistry 2008 : 9th international conference on fundamental and applied aspects of physical chemistry",
title = "Study of valsartan interaction with micelles as a model system for biomembrane",
volume = "1",
pages = "366-368",
url = "https://hdl.handle.net/21.15107/rcub_vinar_9370"
}

Čudina, O., Janković, I. A., Brborić, J., Karljiković-Rajić, K.,& Vladimirov, S.. (2008). Study of valsartan interaction with micelles as a model system for biomembrane. in Physical chemistry 2008 : 9th international conference on fundamental and applied aspects of physical chemistry
Society of Physical Chemists of Serbia., 1, 366-368.
https://hdl.handle.net/21.15107/rcub_vinar_9370

Čudina O, Janković IA, Brborić J, Karljiković-Rajić K, Vladimirov S. Study of valsartan interaction with micelles as a model system for biomembrane. in Physical chemistry 2008 : 9th international conference on fundamental and applied aspects of physical chemistry. 2008;1:366-368.
https://hdl.handle.net/21.15107/rcub_vinar_9370 .

Čudina, Olivera, Janković, Ivana A., Brborić, Jasmina, Karljiković-Rajić, Katarina, Vladimirov, Sote, "Study of valsartan interaction with micelles as a model system for biomembrane" in Physical chemistry 2008 : 9th international conference on fundamental and applied aspects of physical chemistry, 1 (2008):366-368,
https://hdl.handle.net/21.15107/rcub_vinar_9370 .

TY  - JOUR
AU  - Čudina, Olivera
AU  - Brborić, Jasmina
AU  - Janković, Ivana A.
AU  - Karljiković-Rajić, Katarina.
AU  - Vladimirova, S.
PY  - 2008
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/3494
AB  - In this study, the interaction of valsartan (VAL), an angiotensin II receptor antagonist, with cationic surfactant cetyltrimethylammonium bromide (CTAB) was investigated. The effect of cationic micelles on spectroscopic and acid-base properties of VAL was carried out using UV spectrophotometry at physiological conditions (pH 7.4). The binding of VAL to CTAB micelles implied a shift in drug acidity constant (pK(a)(water) - pK(a)(micelle) = 1.69) proving the great affinity of VAL dianion for the positively charged CTAB micelle surface. To quantify the degree of VAL/CTAB interaction, two constants were calculated by using mathematical models: micelle/water partition coefficient (K-x) and drug/micelle binding constant (K-b). The decrease of K-x with VAL concentration, obtained by using pseudo-phase model, is consistent with an adsorption-like phenomenon. From the dependence of differential absorbance at lambda = 295 nm on CTAB concentration, by using mathematical model that treats the solubilization of VAL dianion as its binding to specific sites in the micelles (Langmuir adsorption isotherm), the binding constant (K-b = (2.50 +/- 10.49) x 10(4) M-1) was obtained. Binding constant VAL/CTAB was also calculated using micellar liquid chromatography (MLC). (C) 2008 Elsevier B.V. All rights reserved.
T2  - Colloids and Surfaces. B: Biointerfaces
T1  - Study of valsartan interaction with micelles as a model system for biomembranes
VL  - 65
IS  - 1
SP  - 80
EP  - 84
DO  - 10.1016/j.colsurfb.2008.03.002
ER  - 

@article{
author = "Čudina, Olivera and Brborić, Jasmina and Janković, Ivana A. and Karljiković-Rajić, Katarina. and Vladimirova, S.",
year = "2008",
abstract = "In this study, the interaction of valsartan (VAL), an angiotensin II receptor antagonist, with cationic surfactant cetyltrimethylammonium bromide (CTAB) was investigated. The effect of cationic micelles on spectroscopic and acid-base properties of VAL was carried out using UV spectrophotometry at physiological conditions (pH 7.4). The binding of VAL to CTAB micelles implied a shift in drug acidity constant (pK(a)(water) - pK(a)(micelle) = 1.69) proving the great affinity of VAL dianion for the positively charged CTAB micelle surface. To quantify the degree of VAL/CTAB interaction, two constants were calculated by using mathematical models: micelle/water partition coefficient (K-x) and drug/micelle binding constant (K-b). The decrease of K-x with VAL concentration, obtained by using pseudo-phase model, is consistent with an adsorption-like phenomenon. From the dependence of differential absorbance at lambda = 295 nm on CTAB concentration, by using mathematical model that treats the solubilization of VAL dianion as its binding to specific sites in the micelles (Langmuir adsorption isotherm), the binding constant (K-b = (2.50 +/- 10.49) x 10(4) M-1) was obtained. Binding constant VAL/CTAB was also calculated using micellar liquid chromatography (MLC). (C) 2008 Elsevier B.V. All rights reserved.",
journal = "Colloids and Surfaces. B: Biointerfaces",
title = "Study of valsartan interaction with micelles as a model system for biomembranes",
volume = "65",
number = "1",
pages = "80-84",
doi = "10.1016/j.colsurfb.2008.03.002"
}

Čudina, O., Brborić, J., Janković, I. A., Karljiković-Rajić, Katarina.,& Vladimirova, S.. (2008). Study of valsartan interaction with micelles as a model system for biomembranes. in Colloids and Surfaces. B: Biointerfaces, 65(1), 80-84.
https://doi.org/10.1016/j.colsurfb.2008.03.002

Čudina O, Brborić J, Janković IA, Karljiković-Rajić K, Vladimirova S. Study of valsartan interaction with micelles as a model system for biomembranes. in Colloids and Surfaces. B: Biointerfaces. 2008;65(1):80-84.
doi:10.1016/j.colsurfb.2008.03.002 .

Čudina, Olivera, Brborić, Jasmina, Janković, Ivana A., Karljiković-Rajić, Katarina., Vladimirova, S., "Study of valsartan interaction with micelles as a model system for biomembranes" in Colloids and Surfaces. B: Biointerfaces, 65, no. 1 (2008):80-84,
https://doi.org/10.1016/j.colsurfb.2008.03.002 . .

TY  - JOUR
AU  - Brborić, Jasmina
AU  - Jovanović, Moma S.
AU  - Popovic, G
AU  - Kapetanovic, V
AU  - Vladimirov, Sote
PY  - 2006
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/2981
AB  - The acid-base equilibria of a novel hepatobiliary imaging agent, 2,4-diiodo-6-methylphenylcarbamoylmethyl iminodiacetic acid (DIIODIDA) were studied. The potentiometrically determined acidity constants of the second carboxylic group, amino and amide groups were pK(2) = 2.52 +/- 0.02; pK(3) = 5.86 +/- 0.06 and pK(4) = 10.9 +/- 0.1. The determinations were performed at 25 degrees C and an ionic strength of 0.1 mol/dm(3) (NaCl). The acidity constants (pK(1) = 1.3 +/- 0.4) corresponding to the first carboxylic group was determined indirectly, on the basis of equilibrium constants obtained in a heterogeneous system, at 25 degrees C and an ionic strength 1 mol/dm(3) (HCl, NaCl). DIIODIDA was labeled with teclinctiurn-99m, and the influence of pH on the yield of labeling was investigated. It was found that labeling within the pH range from 5.5 to 6.5 provided a radiopharmaceutical of high radiochemical purity ( GT 98%).
T2  - Journal of the Serbian Chemical Society
T1  - Acid-base equilibria of 2,4-diiodo-6-methylphenylearbamoylmethyl iminodiacetic acid and its labeling with technetium-99m
VL  - 71
IS  - 1
SP  - 55
EP  - 65
DO  - 10.2298/JSC0601055B
ER  - 

@article{
author = "Brborić, Jasmina and Jovanović, Moma S. and Popovic, G and Kapetanovic, V and Vladimirov, Sote",
year = "2006",
abstract = "The acid-base equilibria of a novel hepatobiliary imaging agent, 2,4-diiodo-6-methylphenylcarbamoylmethyl iminodiacetic acid (DIIODIDA) were studied. The potentiometrically determined acidity constants of the second carboxylic group, amino and amide groups were pK(2) = 2.52 +/- 0.02; pK(3) = 5.86 +/- 0.06 and pK(4) = 10.9 +/- 0.1. The determinations were performed at 25 degrees C and an ionic strength of 0.1 mol/dm(3) (NaCl). The acidity constants (pK(1) = 1.3 +/- 0.4) corresponding to the first carboxylic group was determined indirectly, on the basis of equilibrium constants obtained in a heterogeneous system, at 25 degrees C and an ionic strength 1 mol/dm(3) (HCl, NaCl). DIIODIDA was labeled with teclinctiurn-99m, and the influence of pH on the yield of labeling was investigated. It was found that labeling within the pH range from 5.5 to 6.5 provided a radiopharmaceutical of high radiochemical purity ( GT 98%).",
journal = "Journal of the Serbian Chemical Society",
title = "Acid-base equilibria of 2,4-diiodo-6-methylphenylearbamoylmethyl iminodiacetic acid and its labeling with technetium-99m",
volume = "71",
number = "1",
pages = "55-65",
doi = "10.2298/JSC0601055B"
}

Brborić, J., Jovanović, M. S., Popovic, G., Kapetanovic, V.,& Vladimirov, S.. (2006). Acid-base equilibria of 2,4-diiodo-6-methylphenylearbamoylmethyl iminodiacetic acid and its labeling with technetium-99m. in Journal of the Serbian Chemical Society, 71(1), 55-65.
https://doi.org/10.2298/JSC0601055B

Brborić J, Jovanović MS, Popovic G, Kapetanovic V, Vladimirov S. Acid-base equilibria of 2,4-diiodo-6-methylphenylearbamoylmethyl iminodiacetic acid and its labeling with technetium-99m. in Journal of the Serbian Chemical Society. 2006;71(1):55-65.
doi:10.2298/JSC0601055B .

Brborić, Jasmina, Jovanović, Moma S., Popovic, G, Kapetanovic, V, Vladimirov, Sote, "Acid-base equilibria of 2,4-diiodo-6-methylphenylearbamoylmethyl iminodiacetic acid and its labeling with technetium-99m" in Journal of the Serbian Chemical Society, 71, no. 1 (2006):55-65,
https://doi.org/10.2298/JSC0601055B . .

TY  - CONF
AU  - Brborić, Jasmina
AU  - Jovanović, M.
AU  - Vladimirov, Sote
PY  - 2004
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/9603
AB  - The ionization constants of 2,4-diiodo-6-methylphenylcarbamoylmethyl iminodiacetic acid were determined: pK1 1.3 (the first carboxylic group), pK2 2.52 (the second carboxylic group), pK3 5.86 (amino group) and pK4 10.85 (amide group). The determination were performed at 25o C.
PB  - Society of Physical Chemists of Serbia
C3  - Physical chemistry 2004: 7th international conference on fundemental and applied aspract of physical chemistry
T1  - Determination of the ionization constants of 2,4-DIIODO-6-methylphenyl carbamoylmethyl iminodiacetic acid
VL  - 2
SP  - 850
EP  - 852
UR  - https://hdl.handle.net/21.15107/rcub_vinar_9603
ER  - 

@conference{
author = "Brborić, Jasmina and Jovanović, M. and Vladimirov, Sote",
year = "2004",
abstract = "The ionization constants of 2,4-diiodo-6-methylphenylcarbamoylmethyl iminodiacetic acid were determined: pK1 1.3 (the first carboxylic group), pK2 2.52 (the second carboxylic group), pK3 5.86 (amino group) and pK4 10.85 (amide group). The determination were performed at 25o C.",
publisher = "Society of Physical Chemists of Serbia",
journal = "Physical chemistry 2004: 7th international conference on fundemental and applied aspract of physical chemistry",
title = "Determination of the ionization constants of 2,4-DIIODO-6-methylphenyl carbamoylmethyl iminodiacetic acid",
volume = "2",
pages = "850-852",
url = "https://hdl.handle.net/21.15107/rcub_vinar_9603"
}

Brborić, J., Jovanović, M.,& Vladimirov, S.. (2004). Determination of the ionization constants of 2,4-DIIODO-6-methylphenyl carbamoylmethyl iminodiacetic acid. in Physical chemistry 2004: 7th international conference on fundemental and applied aspract of physical chemistry
Society of Physical Chemists of Serbia., 2, 850-852.
https://hdl.handle.net/21.15107/rcub_vinar_9603

Brborić J, Jovanović M, Vladimirov S. Determination of the ionization constants of 2,4-DIIODO-6-methylphenyl carbamoylmethyl iminodiacetic acid. in Physical chemistry 2004: 7th international conference on fundemental and applied aspract of physical chemistry. 2004;2:850-852.
https://hdl.handle.net/21.15107/rcub_vinar_9603 .

Brborić, Jasmina, Jovanović, M., Vladimirov, Sote, "Determination of the ionization constants of 2,4-DIIODO-6-methylphenyl carbamoylmethyl iminodiacetic acid" in Physical chemistry 2004: 7th international conference on fundemental and applied aspract of physical chemistry, 2 (2004):850-852,
https://hdl.handle.net/21.15107/rcub_vinar_9603 .

TY  - CONF
AU  - Jovanović, Moma S.
AU  - Vranješ, Sanja
AU  - Brborić, Jasmina
AU  - Vladimirov, Sote
AU  - Orlić, Milan P.
PY  - 2004
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/9501
AB  - The lipophilicity expressed as the partition coefficient of newly synthesized IDA derivatives (DIETHYLIODIDA and DIIODIDA) and commercial IDA derivatives as well as theirs corresponding complexes with 99mTc was calculated using two computer programs: PACO and ChemOffice Ultra 2003 and determinated experimentally by extraction method. The correlation between: log P calculated by two programs; ChemOffice program and experimental log P; and PACO program and experimental log P, is r=0.76, r=0.81 and r=0.91 respectively.
PB  - Society of Physical Chemists of Serbia
C3  - Physical chemistry 2004: 7th international conference on fundemental and applied aspract of physical chemistry
T1  - Comparison of experimental and calculation procedures for estimation of lipophilicity: new ida derivatives
VL  - 1
SP  - 398
EP  - 400
UR  - https://hdl.handle.net/21.15107/rcub_vinar_9501
ER  - 

@conference{
author = "Jovanović, Moma S. and Vranješ, Sanja and Brborić, Jasmina and Vladimirov, Sote and Orlić, Milan P.",
year = "2004",
abstract = "The lipophilicity expressed as the partition coefficient of newly synthesized IDA derivatives (DIETHYLIODIDA and DIIODIDA) and commercial IDA derivatives as well as theirs corresponding complexes with 99mTc was calculated using two computer programs: PACO and ChemOffice Ultra 2003 and determinated experimentally by extraction method. The correlation between: log P calculated by two programs; ChemOffice program and experimental log P; and PACO program and experimental log P, is r=0.76, r=0.81 and r=0.91 respectively.",
publisher = "Society of Physical Chemists of Serbia",
journal = "Physical chemistry 2004: 7th international conference on fundemental and applied aspract of physical chemistry",
title = "Comparison of experimental and calculation procedures for estimation of lipophilicity: new ida derivatives",
volume = "1",
pages = "398-400",
url = "https://hdl.handle.net/21.15107/rcub_vinar_9501"
}

Jovanović, M. S., Vranješ, S., Brborić, J., Vladimirov, S.,& Orlić, M. P.. (2004). Comparison of experimental and calculation procedures for estimation of lipophilicity: new ida derivatives. in Physical chemistry 2004: 7th international conference on fundemental and applied aspract of physical chemistry
Society of Physical Chemists of Serbia., 1, 398-400.
https://hdl.handle.net/21.15107/rcub_vinar_9501

Jovanović MS, Vranješ S, Brborić J, Vladimirov S, Orlić MP. Comparison of experimental and calculation procedures for estimation of lipophilicity: new ida derivatives. in Physical chemistry 2004: 7th international conference on fundemental and applied aspract of physical chemistry. 2004;1:398-400.
https://hdl.handle.net/21.15107/rcub_vinar_9501 .

Jovanović, Moma S., Vranješ, Sanja, Brborić, Jasmina, Vladimirov, Sote, Orlić, Milan P., "Comparison of experimental and calculation procedures for estimation of lipophilicity: new ida derivatives" in Physical chemistry 2004: 7th international conference on fundemental and applied aspract of physical chemistry, 1 (2004):398-400,
https://hdl.handle.net/21.15107/rcub_vinar_9501 .

TY  - JOUR
AU  - Brborić, Jasmina
AU  - Vladimirov, Sote
AU  - Jovanović, Moma S.
AU  - Dogović, N
PY  - 2004
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/2794
AB  - The synthesis and characterization of N-[2-[[4-iodo-2,6-bis(1-methylethyl)phenyl]amino]-2-oxoethyl]-N-(carboxymethyl)glycine and N-[2-[(4-iodo-2,6-diethylphenyl)amino]-2-oxoethyl]-N-(carboxymethyl)glycine is presented, as well as a modified and improved synthesis of N-[2-[(2,4-diiodo-6-methylphenyl)amino]-2-oxoethyl]-N-(carboxymethyl)glycine. These compounds are new agents for hepatobiliary imaging.
T2  - Monatshefte Fur Chemie
T1  - The synthesis of novel iodinated iminodiacetic acid analogues as hepatobiliary imaging agents
VL  - 135
IS  - 8
SP  - 1009
EP  - 1014
DO  - 10.1007/s00706-004-0174-x
ER  - 

@article{
author = "Brborić, Jasmina and Vladimirov, Sote and Jovanović, Moma S. and Dogović, N",
year = "2004",
abstract = "The synthesis and characterization of N-[2-[[4-iodo-2,6-bis(1-methylethyl)phenyl]amino]-2-oxoethyl]-N-(carboxymethyl)glycine and N-[2-[(4-iodo-2,6-diethylphenyl)amino]-2-oxoethyl]-N-(carboxymethyl)glycine is presented, as well as a modified and improved synthesis of N-[2-[(2,4-diiodo-6-methylphenyl)amino]-2-oxoethyl]-N-(carboxymethyl)glycine. These compounds are new agents for hepatobiliary imaging.",
journal = "Monatshefte Fur Chemie",
title = "The synthesis of novel iodinated iminodiacetic acid analogues as hepatobiliary imaging agents",
volume = "135",
number = "8",
pages = "1009-1014",
doi = "10.1007/s00706-004-0174-x"
}

Brborić, J., Vladimirov, S., Jovanović, M. S.,& Dogović, N.. (2004). The synthesis of novel iodinated iminodiacetic acid analogues as hepatobiliary imaging agents. in Monatshefte Fur Chemie, 135(8), 1009-1014.
https://doi.org/10.1007/s00706-004-0174-x

Brborić J, Vladimirov S, Jovanović MS, Dogović N. The synthesis of novel iodinated iminodiacetic acid analogues as hepatobiliary imaging agents. in Monatshefte Fur Chemie. 2004;135(8):1009-1014.
doi:10.1007/s00706-004-0174-x .

Brborić, Jasmina, Vladimirov, Sote, Jovanović, Moma S., Dogović, N, "The synthesis of novel iodinated iminodiacetic acid analogues as hepatobiliary imaging agents" in Monatshefte Fur Chemie, 135, no. 8 (2004):1009-1014,
https://doi.org/10.1007/s00706-004-0174-x . .

TY  - JOUR
AU  - Jovanović, Moma S.
AU  - Brborić, Jasmina
AU  - Vladimirov, Sote
AU  - Suturkova, L
PY  - 2000
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/2380
AB  - The partition coefficient (log P) for n-octanol/water system was calculated applying PACO program for various theoretically possible mono and dihalogenated IDA derivatives. Some of the synthesized ligands (SOLCOIODIDA, IODIDA and DIIODIDA) were labeled with the technetium-99m. The biodistribution and influence of bilirubin on their biokinetics were investigated in rats. The correlation between partition coefficients of ligands increase (log P) and better hepatobiliary properties of Tc-99m-IDA derivatives was determined. The values of log P increase from 1.16 for SOLCOIODIDA, 3.11 for IODIDA to 3.47 for DIIODIDA. In correlation with these results, biliary excretion decreased for 59% for Tc-99m-SOLCOIODIDA and 11% for Tc-99m-IODIDA and Tc-99m-DIIODIDA under hyperbilirubinemia (3.5 min after injection) and 45%, 11% and 0.38% respectively (15 min after injection). The highest biliary excretion had Tc-99m-DIIODIDA (55.4% for 3.5 min). Considering the correlation between hepatobiliary properties and log P, the evaluation of biological properties for various trifluoromethyl mono and dihalogenated IDA derivatives was performed on the basis of the calculated log P in order to synthetize a new radiopharmaceutical for hepatobiliary scintigraphy.
T2  - Journal of Radioanalytical and Nuclear Chemistry
T1  - Correlation between lipophilicity of the ligands and the hepatobiliary properties of the radiopharmaceuticals: Approach to the development of new IDA derivatives
VL  - 245
IS  - 3
SP  - 555
EP  - 560
DO  - 10.1023/A:1006709310527
ER  - 

@article{
author = "Jovanović, Moma S. and Brborić, Jasmina and Vladimirov, Sote and Suturkova, L",
year = "2000",
abstract = "The partition coefficient (log P) for n-octanol/water system was calculated applying PACO program for various theoretically possible mono and dihalogenated IDA derivatives. Some of the synthesized ligands (SOLCOIODIDA, IODIDA and DIIODIDA) were labeled with the technetium-99m. The biodistribution and influence of bilirubin on their biokinetics were investigated in rats. The correlation between partition coefficients of ligands increase (log P) and better hepatobiliary properties of Tc-99m-IDA derivatives was determined. The values of log P increase from 1.16 for SOLCOIODIDA, 3.11 for IODIDA to 3.47 for DIIODIDA. In correlation with these results, biliary excretion decreased for 59% for Tc-99m-SOLCOIODIDA and 11% for Tc-99m-IODIDA and Tc-99m-DIIODIDA under hyperbilirubinemia (3.5 min after injection) and 45%, 11% and 0.38% respectively (15 min after injection). The highest biliary excretion had Tc-99m-DIIODIDA (55.4% for 3.5 min). Considering the correlation between hepatobiliary properties and log P, the evaluation of biological properties for various trifluoromethyl mono and dihalogenated IDA derivatives was performed on the basis of the calculated log P in order to synthetize a new radiopharmaceutical for hepatobiliary scintigraphy.",
journal = "Journal of Radioanalytical and Nuclear Chemistry",
title = "Correlation between lipophilicity of the ligands and the hepatobiliary properties of the radiopharmaceuticals: Approach to the development of new IDA derivatives",
volume = "245",
number = "3",
pages = "555-560",
doi = "10.1023/A:1006709310527"
}

Jovanović, M. S., Brborić, J., Vladimirov, S.,& Suturkova, L.. (2000). Correlation between lipophilicity of the ligands and the hepatobiliary properties of the radiopharmaceuticals: Approach to the development of new IDA derivatives. in Journal of Radioanalytical and Nuclear Chemistry, 245(3), 555-560.
https://doi.org/10.1023/A:1006709310527

Jovanović MS, Brborić J, Vladimirov S, Suturkova L. Correlation between lipophilicity of the ligands and the hepatobiliary properties of the radiopharmaceuticals: Approach to the development of new IDA derivatives. in Journal of Radioanalytical and Nuclear Chemistry. 2000;245(3):555-560.
doi:10.1023/A:1006709310527 .

Jovanović, Moma S., Brborić, Jasmina, Vladimirov, Sote, Suturkova, L, "Correlation between lipophilicity of the ligands and the hepatobiliary properties of the radiopharmaceuticals: Approach to the development of new IDA derivatives" in Journal of Radioanalytical and Nuclear Chemistry, 245, no. 3 (2000):555-560,
https://doi.org/10.1023/A:1006709310527 . .

TY  - JOUR
AU  - Jovanović, Moma S.
AU  - Brborić, Jasmina
AU  - Vladimirov, Sote
AU  - Zmbova, B
AU  - Vuksanovic, LJ
AU  - Zivanov-Stakic, D
AU  - Obradović, V
PY  - 1999
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/2246
AB  - A new diiodine substituted LDA derivative, 2,4-diiodine-6-methyl IDA (DIIODIDA) was synthesized and labeled with Tc-99m. It was established that Tc-99m-DIIODIDA had high radiochemical purity. Biodistribution and influence of bilirubin on Tc-99m-DIIODIDA biokinetics has been studied in rats and compared to the corresponding results for Tc-99m-SOLCOIODIDA. Related to Tc-99m-SOLCOIODIDA, Tc-99m-DIIODIDA has much better biliary exretion (55.18 versus 43.63%). No change of Tc-99m-DIIODIDA biokinetics, under influence of bilirubin was noticed. Biliary excretion of Tc-99m-SOLCOIODIDA has been reduced for about 60%. The protein binding of Tc-99m-DIIODIDA and Tc-99m-SOLCOIODIDA were also determined, using in vitro method of precipitation. These results showed that Tc-99m-DIIODIDA hepatobiliary imaging agent is superior to the presently used Tc-99m-monoiodine IDA derivatives.
T2  - Journal of Radioanalytical and Nuclear Chemistry
T1  - New Tc-99m-diiodine substituted IDA derivative (DIIODIDA) for hepatobiliary imaging
VL  - 240
IS  - 1
SP  - 321
EP  - 324
DO  - 10.1007/BF02349171
ER  - 

@article{
author = "Jovanović, Moma S. and Brborić, Jasmina and Vladimirov, Sote and Zmbova, B and Vuksanovic, LJ and Zivanov-Stakic, D and Obradović, V",
year = "1999",
abstract = "A new diiodine substituted LDA derivative, 2,4-diiodine-6-methyl IDA (DIIODIDA) was synthesized and labeled with Tc-99m. It was established that Tc-99m-DIIODIDA had high radiochemical purity. Biodistribution and influence of bilirubin on Tc-99m-DIIODIDA biokinetics has been studied in rats and compared to the corresponding results for Tc-99m-SOLCOIODIDA. Related to Tc-99m-SOLCOIODIDA, Tc-99m-DIIODIDA has much better biliary exretion (55.18 versus 43.63%). No change of Tc-99m-DIIODIDA biokinetics, under influence of bilirubin was noticed. Biliary excretion of Tc-99m-SOLCOIODIDA has been reduced for about 60%. The protein binding of Tc-99m-DIIODIDA and Tc-99m-SOLCOIODIDA were also determined, using in vitro method of precipitation. These results showed that Tc-99m-DIIODIDA hepatobiliary imaging agent is superior to the presently used Tc-99m-monoiodine IDA derivatives.",
journal = "Journal of Radioanalytical and Nuclear Chemistry",
title = "New Tc-99m-diiodine substituted IDA derivative (DIIODIDA) for hepatobiliary imaging",
volume = "240",
number = "1",
pages = "321-324",
doi = "10.1007/BF02349171"
}

Jovanović, M. S., Brborić, J., Vladimirov, S., Zmbova, B., Vuksanovic, L., Zivanov-Stakic, D.,& Obradović, V.. (1999). New Tc-99m-diiodine substituted IDA derivative (DIIODIDA) for hepatobiliary imaging. in Journal of Radioanalytical and Nuclear Chemistry, 240(1), 321-324.
https://doi.org/10.1007/BF02349171

Jovanović MS, Brborić J, Vladimirov S, Zmbova B, Vuksanovic L, Zivanov-Stakic D, Obradović V. New Tc-99m-diiodine substituted IDA derivative (DIIODIDA) for hepatobiliary imaging. in Journal of Radioanalytical and Nuclear Chemistry. 1999;240(1):321-324.
doi:10.1007/BF02349171 .

Jovanović, Moma S., Brborić, Jasmina, Vladimirov, Sote, Zmbova, B, Vuksanovic, LJ, Zivanov-Stakic, D, Obradović, V, "New Tc-99m-diiodine substituted IDA derivative (DIIODIDA) for hepatobiliary imaging" in Journal of Radioanalytical and Nuclear Chemistry, 240, no. 1 (1999):321-324,
https://doi.org/10.1007/BF02349171 . .

TY  - JOUR
AU  - Jovanović, Moma S.
AU  - Vuksanovic, L
AU  - Brborić, Jasmina
AU  - Vladimirov, Sote
AU  - Živanov-Stakić, Dobrila
PY  - 1996
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/2027
T2  - Jugoslovenska Medicinska Biohemija
T1  - Interaction of Tc-99m-IODIDE IDA derivatives substituted with HSA
VL  - 15
IS  - 4
SP  - 266
EP  - 266
UR  - https://hdl.handle.net/21.15107/rcub_vinar_2027
ER  - 

@article{
author = "Jovanović, Moma S. and Vuksanovic, L and Brborić, Jasmina and Vladimirov, Sote and Živanov-Stakić, Dobrila",
year = "1996",
journal = "Jugoslovenska Medicinska Biohemija",
title = "Interaction of Tc-99m-IODIDE IDA derivatives substituted with HSA",
volume = "15",
number = "4",
pages = "266-266",
url = "https://hdl.handle.net/21.15107/rcub_vinar_2027"
}

Jovanović, M. S., Vuksanovic, L., Brborić, J., Vladimirov, S.,& Živanov-Stakić, D.. (1996). Interaction of Tc-99m-IODIDE IDA derivatives substituted with HSA. in Jugoslovenska Medicinska Biohemija, 15(4), 266-266.
https://hdl.handle.net/21.15107/rcub_vinar_2027

Jovanović MS, Vuksanovic L, Brborić J, Vladimirov S, Živanov-Stakić D. Interaction of Tc-99m-IODIDE IDA derivatives substituted with HSA. in Jugoslovenska Medicinska Biohemija. 1996;15(4):266-266.
https://hdl.handle.net/21.15107/rcub_vinar_2027 .

Jovanović, Moma S., Vuksanovic, L, Brborić, Jasmina, Vladimirov, Sote, Živanov-Stakić, Dobrila, "Interaction of Tc-99m-IODIDE IDA derivatives substituted with HSA" in Jugoslovenska Medicinska Biohemija, 15, no. 4 (1996):266-266,
https://hdl.handle.net/21.15107/rcub_vinar_2027 .