TY  - JOUR
AU  - Barišić, Anita
AU  - Stanković, Aleksandra
AU  - Stojković, Ljiljana
AU  - Pereza, Nina
AU  - Ostojić, Saša
AU  - Peterlin, Ana
AU  - Peterlin, Borut
AU  - Vraneković, Jadranka
PY  - 2022
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10022
AB  - Despite considerable effort aimed at decreasing the incidence of spontaneous preterm birth (SPTB), it remains the leading cause of infant mortality and morbidity. The aim of this study was to evaluate maternal LINE-1 DNA methylation (DNAm), along with DNMT polymorphisms and factors proposed to modulate DNAm, in patients who delivered early preterm. This case-control study included women who delivered spontaneously early preterm (23–336/7 weeks of gestation), and control women. DNAm was analyzed in peripheral blood lymphocytes by quantification of LINE-1 DNAm using the MethyLight method. There was no significant difference in LINE-1 DNAm between patients with early PTB and controls. Among the investigated predictors, only the history of previous PTB was significantly associated with LINE-1 DNAm in PTB patients (β = −0.407; R2 = 0.131; p = 0.011). The regression analysis showed the effect of DNMT3B rs1569686 TT+TG genotypes on LINE-1 DNAm in patients with familial PTB (β = −0.524; R2 = 0.275; p = 0.037). Our findings suggest novel associations of maternal LINE-1 DNA hypomethylation with DNMT3B rs1569686 T allele. These results also contribute to the understanding of a complex (epi)genetic and environmental relationship underlying the early PTB.
T2  - Biological Research For Nursing
T1  - Maternal LINE-1 DNA Methylation in Early Spontaneous Preterm Birth
VL  - 24
IS  - 1
SP  - 85
EP  - 93
DO  - 10.1177/10998004211043571
ER  - 

@article{
author = "Barišić, Anita and Stanković, Aleksandra and Stojković, Ljiljana and Pereza, Nina and Ostojić, Saša and Peterlin, Ana and Peterlin, Borut and Vraneković, Jadranka",
year = "2022",
abstract = "Despite considerable effort aimed at decreasing the incidence of spontaneous preterm birth (SPTB), it remains the leading cause of infant mortality and morbidity. The aim of this study was to evaluate maternal LINE-1 DNA methylation (DNAm), along with DNMT polymorphisms and factors proposed to modulate DNAm, in patients who delivered early preterm. This case-control study included women who delivered spontaneously early preterm (23–336/7 weeks of gestation), and control women. DNAm was analyzed in peripheral blood lymphocytes by quantification of LINE-1 DNAm using the MethyLight method. There was no significant difference in LINE-1 DNAm between patients with early PTB and controls. Among the investigated predictors, only the history of previous PTB was significantly associated with LINE-1 DNAm in PTB patients (β = −0.407; R2 = 0.131; p = 0.011). The regression analysis showed the effect of DNMT3B rs1569686 TT+TG genotypes on LINE-1 DNAm in patients with familial PTB (β = −0.524; R2 = 0.275; p = 0.037). Our findings suggest novel associations of maternal LINE-1 DNA hypomethylation with DNMT3B rs1569686 T allele. These results also contribute to the understanding of a complex (epi)genetic and environmental relationship underlying the early PTB.",
journal = "Biological Research For Nursing",
title = "Maternal LINE-1 DNA Methylation in Early Spontaneous Preterm Birth",
volume = "24",
number = "1",
pages = "85-93",
doi = "10.1177/10998004211043571"
}

Barišić, A., Stanković, A., Stojković, L., Pereza, N., Ostojić, S., Peterlin, A., Peterlin, B.,& Vraneković, J.. (2022). Maternal LINE-1 DNA Methylation in Early Spontaneous Preterm Birth. in Biological Research For Nursing, 24(1), 85-93.
https://doi.org/10.1177/10998004211043571

Barišić A, Stanković A, Stojković L, Pereza N, Ostojić S, Peterlin A, Peterlin B, Vraneković J. Maternal LINE-1 DNA Methylation in Early Spontaneous Preterm Birth. in Biological Research For Nursing. 2022;24(1):85-93.
doi:10.1177/10998004211043571 .

Barišić, Anita, Stanković, Aleksandra, Stojković, Ljiljana, Pereza, Nina, Ostojić, Saša, Peterlin, Ana, Peterlin, Borut, Vraneković, Jadranka, "Maternal LINE-1 DNA Methylation in Early Spontaneous Preterm Birth" in Biological Research For Nursing, 24, no. 1 (2022):85-93,
https://doi.org/10.1177/10998004211043571 . .