Kurtovic, Nada Kraguljac

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  • Kurtovic, Nada Kraguljac (2)
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Author's Bibliography

Concomitant aberrant methylation of p15 and MGMT genes in acute myeloid leukemia: association with a particular immunophenotype of blast cells

Kurtovic, Nada Kraguljac; Krajnović, Milena M.; Bogdanović, Andrija; Suvajdzic, Nada; Jovanović, Jelica; Dimitrijević, Bogomir B.; Čolović, Milica; Krtolica-Žikić, Koviljka

(2012)

TY  - JOUR
AU  - Kurtovic, Nada Kraguljac
AU  - Krajnović, Milena M.
AU  - Bogdanović, Andrija
AU  - Suvajdzic, Nada
AU  - Jovanović, Jelica
AU  - Dimitrijević, Bogomir B.
AU  - Čolović, Milica
AU  - Krtolica-Žikić, Koviljka
PY  - 2012
UR  - http://vinar.vin.bg.ac.rs/handle/123456789/5173
AB  - In this study, methylation-specific polymerase chain reaction (MS-PCR) was used to define the methylation status of the target promoter sequences of p15 and MGMT genes in the group of 21 adult patients with acute myeloid leukemia (AML). The incidence of aberrant hypermethylation of p15 gene (71 %) was higher comparing to MGMT gene (33 %), whereas concomitant methylation of both genes had 24 % of the patients. Although the incidence of cytogenetic abnormalities between the groups with a different methylation status of p15 and/or MGMT genes was not significantly different, we observed general trend of clustering of abnormalities with adverse prognosis into groups with concomitant hypermethylation of both genes and only p15 gene. Also, we showed that AML patients with concomitant methylation of p15/MGMT genes had a higher proportion of leukemic blast cells characterized with specific expression of individual leukocyte surface antigens (CD117(+)/CD7(+)/CD34(+)/CD15(-)), indicating leukemic cells as early myeloid progenitors. Although we could not prove that hypermethylation of p15 and/or MGMT genes is predictive parameter for response to therapy and overall survival, we noticed that AML patients with comethylated p15/MGMT genes or methylated p15 gene exhibited a higher frequency of early death, lower frequency of complete remissions as well as a trend for shorter overall survival. Assessing of the methylation status of p15 and MGMT genes may allow stratification of patients with AML into distinct groups with potentially different prognosis.
T2  - Medical Oncology
T1  - Concomitant aberrant methylation of p15 and MGMT genes in acute myeloid leukemia: association with a particular immunophenotype of blast cells
VL  - 29
IS  - 5
SP  - 3547
EP  - 3556
DO  - 10.1007/s12032-012-0289-6
ER  - 
@article{
author = "Kurtovic, Nada Kraguljac and Krajnović, Milena M. and Bogdanović, Andrija and Suvajdzic, Nada and Jovanović, Jelica and Dimitrijević, Bogomir B. and Čolović, Milica and Krtolica-Žikić, Koviljka",
year = "2012",
abstract = "In this study, methylation-specific polymerase chain reaction (MS-PCR) was used to define the methylation status of the target promoter sequences of p15 and MGMT genes in the group of 21 adult patients with acute myeloid leukemia (AML). The incidence of aberrant hypermethylation of p15 gene (71 %) was higher comparing to MGMT gene (33 %), whereas concomitant methylation of both genes had 24 % of the patients. Although the incidence of cytogenetic abnormalities between the groups with a different methylation status of p15 and/or MGMT genes was not significantly different, we observed general trend of clustering of abnormalities with adverse prognosis into groups with concomitant hypermethylation of both genes and only p15 gene. Also, we showed that AML patients with concomitant methylation of p15/MGMT genes had a higher proportion of leukemic blast cells characterized with specific expression of individual leukocyte surface antigens (CD117(+)/CD7(+)/CD34(+)/CD15(-)), indicating leukemic cells as early myeloid progenitors. Although we could not prove that hypermethylation of p15 and/or MGMT genes is predictive parameter for response to therapy and overall survival, we noticed that AML patients with comethylated p15/MGMT genes or methylated p15 gene exhibited a higher frequency of early death, lower frequency of complete remissions as well as a trend for shorter overall survival. Assessing of the methylation status of p15 and MGMT genes may allow stratification of patients with AML into distinct groups with potentially different prognosis.",
journal = "Medical Oncology",
title = "Concomitant aberrant methylation of p15 and MGMT genes in acute myeloid leukemia: association with a particular immunophenotype of blast cells",
volume = "29",
number = "5",
pages = "3547-3556",
doi = "10.1007/s12032-012-0289-6"
}
Kurtovic, N. K., Krajnović, M. M., Bogdanović, A., Suvajdzic, N., Jovanović, J., Dimitrijević, B. B., Čolović, M.,& Krtolica-Žikić, K.. (2012). Concomitant aberrant methylation of p15 and MGMT genes in acute myeloid leukemia: association with a particular immunophenotype of blast cells. in Medical Oncology, 29(5), 3547-3556.
https://doi.org/10.1007/s12032-012-0289-6
Kurtovic NK, Krajnović MM, Bogdanović A, Suvajdzic N, Jovanović J, Dimitrijević BB, Čolović M, Krtolica-Žikić K. Concomitant aberrant methylation of p15 and MGMT genes in acute myeloid leukemia: association with a particular immunophenotype of blast cells. in Medical Oncology. 2012;29(5):3547-3556.
doi:10.1007/s12032-012-0289-6 .
Kurtovic, Nada Kraguljac, Krajnović, Milena M., Bogdanović, Andrija, Suvajdzic, Nada, Jovanović, Jelica, Dimitrijević, Bogomir B., Čolović, Milica, Krtolica-Žikić, Koviljka, "Concomitant aberrant methylation of p15 and MGMT genes in acute myeloid leukemia: association with a particular immunophenotype of blast cells" in Medical Oncology, 29, no. 5 (2012):3547-3556,
https://doi.org/10.1007/s12032-012-0289-6 . .
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Frequency of Aberrant Promoter Methylation of P15(Ink4b) and O-6-Methylguanine-Dna Methyltransferase Genes in B-Cell Non-Hodgkin Lymphoma: a Pilot Study

Kurtovic, Nada Kraguljac; Krajnović, Milena M.; Dimitrijević, Bogomir B.; Mihaljevic, Biljana; Gotic, Mirjana; Krtolica-Žikić, Koviljka

(2010)

TY  - JOUR
AU  - Kurtovic, Nada Kraguljac
AU  - Krajnović, Milena M.
AU  - Dimitrijević, Bogomir B.
AU  - Mihaljevic, Biljana
AU  - Gotic, Mirjana
AU  - Krtolica-Žikić, Koviljka
PY  - 2010
UR  - http://vinar.vin.bg.ac.rs/handle/123456789/4045
AB  - The methylation status of the target promoter sequences of p15(INK4B) (p15) and O-6-methylguanine-DNA methyltransferase (MGMT) genes was studied by methylation-specific PCR in 10 adult patients with de novo B-cell non-Hodgkin lymphoma (B-NHL). The aberrant hypermethylation of the p15 gene was more frequent (50%) compared to the hypermethylation of the MGMT gene (30%), and was detected in different types of B-NHL in both genes. Hypermethylation of the MGMT gene occurred exclusively in association with the hypermethylation of the p15 gene. All lymphoma patients with hypermethylation of the p15 and/or MGMT genes had a higher clinical stage of the disease (IV - V). We show the association of anemia and/or thrombocytopenia with the hypermethylation of the p15 gene, ascribing the p15 gene as a potential prognostic marker in B-NHL. Comethylation of MGMT with the p15 gene represents a novel finding and presents both genes as candidates for future studies of the hypermethylation profiles of B-NHL.
T2  - Archives of biological sciences
T1  - Frequency of Aberrant Promoter Methylation of P15(Ink4b) and O-6-Methylguanine-Dna Methyltransferase Genes in B-Cell Non-Hodgkin Lymphoma: a Pilot Study
VL  - 62
IS  - 2
SP  - 211
EP  - 221
DO  - 10.2298/ABS1002211K
ER  - 
@article{
author = "Kurtovic, Nada Kraguljac and Krajnović, Milena M. and Dimitrijević, Bogomir B. and Mihaljevic, Biljana and Gotic, Mirjana and Krtolica-Žikić, Koviljka",
year = "2010",
abstract = "The methylation status of the target promoter sequences of p15(INK4B) (p15) and O-6-methylguanine-DNA methyltransferase (MGMT) genes was studied by methylation-specific PCR in 10 adult patients with de novo B-cell non-Hodgkin lymphoma (B-NHL). The aberrant hypermethylation of the p15 gene was more frequent (50%) compared to the hypermethylation of the MGMT gene (30%), and was detected in different types of B-NHL in both genes. Hypermethylation of the MGMT gene occurred exclusively in association with the hypermethylation of the p15 gene. All lymphoma patients with hypermethylation of the p15 and/or MGMT genes had a higher clinical stage of the disease (IV - V). We show the association of anemia and/or thrombocytopenia with the hypermethylation of the p15 gene, ascribing the p15 gene as a potential prognostic marker in B-NHL. Comethylation of MGMT with the p15 gene represents a novel finding and presents both genes as candidates for future studies of the hypermethylation profiles of B-NHL.",
journal = "Archives of biological sciences",
title = "Frequency of Aberrant Promoter Methylation of P15(Ink4b) and O-6-Methylguanine-Dna Methyltransferase Genes in B-Cell Non-Hodgkin Lymphoma: a Pilot Study",
volume = "62",
number = "2",
pages = "211-221",
doi = "10.2298/ABS1002211K"
}
Kurtovic, N. K., Krajnović, M. M., Dimitrijević, B. B., Mihaljevic, B., Gotic, M.,& Krtolica-Žikić, K.. (2010). Frequency of Aberrant Promoter Methylation of P15(Ink4b) and O-6-Methylguanine-Dna Methyltransferase Genes in B-Cell Non-Hodgkin Lymphoma: a Pilot Study. in Archives of biological sciences, 62(2), 211-221.
https://doi.org/10.2298/ABS1002211K
Kurtovic NK, Krajnović MM, Dimitrijević BB, Mihaljevic B, Gotic M, Krtolica-Žikić K. Frequency of Aberrant Promoter Methylation of P15(Ink4b) and O-6-Methylguanine-Dna Methyltransferase Genes in B-Cell Non-Hodgkin Lymphoma: a Pilot Study. in Archives of biological sciences. 2010;62(2):211-221.
doi:10.2298/ABS1002211K .
Kurtovic, Nada Kraguljac, Krajnović, Milena M., Dimitrijević, Bogomir B., Mihaljevic, Biljana, Gotic, Mirjana, Krtolica-Žikić, Koviljka, "Frequency of Aberrant Promoter Methylation of P15(Ink4b) and O-6-Methylguanine-Dna Methyltransferase Genes in B-Cell Non-Hodgkin Lymphoma: a Pilot Study" in Archives of biological sciences, 62, no. 2 (2010):211-221,
https://doi.org/10.2298/ABS1002211K . .
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