TY  - JOUR
AU  - Stojanović, Marija
AU  - Scepanovic, Ljiljana
AU  - Bosnic, Olivera
AU  - Mitrovic, Dusan
AU  - Jozanov-Stankov, Olga
AU  - Scepanovic, Vuk
AU  - Scepanovic, Radomir
AU  - Stojanovic, Teja
AU  - Ilic, Slobodan
AU  - Đurić, Dragan M.
PY  - 2016
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/1117
AB  - Oxidative stress appears to play a role in the pathogenesis of several inflammatory gastrointestinal diseases. Increased homocysteine levels may play a role in the pathogenesis of Chrons disease and ulcerative colitis. The aim of this study was to examine the influence of homocysteine on the antioxidant status of rat intestine and liver. The levels of thiobarbituric acid reactive substances (TBARS), activity of catalase (CAT) and total antioxidant status (TAS) were investigated in the isolated gut and liver of young male rats in the control group (8 rats) and after 3-hour incubation in high doses of D, L-homocysteine thionolactone (Hcy) (10 mu mol/L) (8 rats). Samples of duodenum, ileum, colon and liver were homogenized in sodium phosphate buffer (1: 10). Homogenates were centrifuged at 10000 for 10 min at 4 degrees C and the supernatant was taken for biochemical assays. Our results showed that high D, L-homocysteine thionolactone concentration reduced enzymatic catalase activity in homogenates of the isolated segments of duodenum (27.04%) p LT 0.01; ileum (37.27%), colon (34.17%) and liver (67.46%) p LT 0.001. Exposition to high D, L-homocysteine thiolactone concentration significantly increased TBARS levels in the duodenum (106.05%), ileum (47.24%), colon (112.75%) and liver (32.07%) (p LT 0.01). Homocysteine also modified the total antioxidant status of homogenates from the duodenum, ileum, colon and liver, increasing by 20.68% (duodenum), 24.74% (ileum), 14.88% (colon) and 19.35% (liver) (p LT 0.001). Homocysteine induced a consistent oxidative stress in rats intestine and liver (reduced activity of catalase and increased level of TBARS), but the elevated activity of TAS in our experiments could be explained as an adaptive response to the generated free radicals which indicates the failure of the total antioxidant defense mechanism to protect the tissues from damage caused by homocysteine.
T2  - Acta Veterinaria, Beograd
T1  - Effects of Acute Administration of D,L-Homocysteine Thiolactone on the Antioxidative Status of Rat Intestine and Liver
VL  - 66
IS  - 1
SP  - 26
EP  - 36
DO  - 10.1515/acve-2016-0002
ER  - 

@article{
author = "Stojanović, Marija and Scepanovic, Ljiljana and Bosnic, Olivera and Mitrovic, Dusan and Jozanov-Stankov, Olga and Scepanovic, Vuk and Scepanovic, Radomir and Stojanovic, Teja and Ilic, Slobodan and Đurić, Dragan M.",
year = "2016",
abstract = "Oxidative stress appears to play a role in the pathogenesis of several inflammatory gastrointestinal diseases. Increased homocysteine levels may play a role in the pathogenesis of Chrons disease and ulcerative colitis. The aim of this study was to examine the influence of homocysteine on the antioxidant status of rat intestine and liver. The levels of thiobarbituric acid reactive substances (TBARS), activity of catalase (CAT) and total antioxidant status (TAS) were investigated in the isolated gut and liver of young male rats in the control group (8 rats) and after 3-hour incubation in high doses of D, L-homocysteine thionolactone (Hcy) (10 mu mol/L) (8 rats). Samples of duodenum, ileum, colon and liver were homogenized in sodium phosphate buffer (1: 10). Homogenates were centrifuged at 10000 for 10 min at 4 degrees C and the supernatant was taken for biochemical assays. Our results showed that high D, L-homocysteine thionolactone concentration reduced enzymatic catalase activity in homogenates of the isolated segments of duodenum (27.04%) p LT 0.01; ileum (37.27%), colon (34.17%) and liver (67.46%) p LT 0.001. Exposition to high D, L-homocysteine thiolactone concentration significantly increased TBARS levels in the duodenum (106.05%), ileum (47.24%), colon (112.75%) and liver (32.07%) (p LT 0.01). Homocysteine also modified the total antioxidant status of homogenates from the duodenum, ileum, colon and liver, increasing by 20.68% (duodenum), 24.74% (ileum), 14.88% (colon) and 19.35% (liver) (p LT 0.001). Homocysteine induced a consistent oxidative stress in rats intestine and liver (reduced activity of catalase and increased level of TBARS), but the elevated activity of TAS in our experiments could be explained as an adaptive response to the generated free radicals which indicates the failure of the total antioxidant defense mechanism to protect the tissues from damage caused by homocysteine.",
journal = "Acta Veterinaria, Beograd",
title = "Effects of Acute Administration of D,L-Homocysteine Thiolactone on the Antioxidative Status of Rat Intestine and Liver",
volume = "66",
number = "1",
pages = "26-36",
doi = "10.1515/acve-2016-0002"
}

Stojanović, M., Scepanovic, L., Bosnic, O., Mitrovic, D., Jozanov-Stankov, O., Scepanovic, V., Scepanovic, R., Stojanovic, T., Ilic, S.,& Đurić, D. M.. (2016). Effects of Acute Administration of D,L-Homocysteine Thiolactone on the Antioxidative Status of Rat Intestine and Liver. in Acta Veterinaria, Beograd, 66(1), 26-36.
https://doi.org/10.1515/acve-2016-0002

Stojanović M, Scepanovic L, Bosnic O, Mitrovic D, Jozanov-Stankov O, Scepanovic V, Scepanovic R, Stojanovic T, Ilic S, Đurić DM. Effects of Acute Administration of D,L-Homocysteine Thiolactone on the Antioxidative Status of Rat Intestine and Liver. in Acta Veterinaria, Beograd. 2016;66(1):26-36.
doi:10.1515/acve-2016-0002 .

Stojanović, Marija, Scepanovic, Ljiljana, Bosnic, Olivera, Mitrovic, Dusan, Jozanov-Stankov, Olga, Scepanovic, Vuk, Scepanovic, Radomir, Stojanovic, Teja, Ilic, Slobodan, Đurić, Dragan M., "Effects of Acute Administration of D,L-Homocysteine Thiolactone on the Antioxidative Status of Rat Intestine and Liver" in Acta Veterinaria, Beograd, 66, no. 1 (2016):26-36,
https://doi.org/10.1515/acve-2016-0002 . .

TY  - JOUR
AU  - Stepić, Milutin
AU  - Maluckov, Aleksandra
AU  - Stojanović, Marija
AU  - Chen, Feng
AU  - Kip, Detlef
PY  - 2008
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/3558
AB  - We study theoretically light beam propagation in one-dimensional periodic media with intensity-resonant nonlinearity. The phenomenon of discrete modulational instability is investigated in detail as well as the conditions for the existence and stability of fundamental lattice and surface soliton modes. According to the linear stability analysis, only on-site solitons are stable. The mobility of lattice solitons is analyzed by both free energy and mapping concepts. Only broad solitons may freely traverse the lattice.
T2  - Physical Review A
T1  - Modulational instability and solitary waves in one-dimensional lattices with intensity-resonant nonlinearity
VL  - 78
IS  - 4
DO  - 10.1103/PhysRevA.78.043819
ER  - 

@article{
author = "Stepić, Milutin and Maluckov, Aleksandra and Stojanović, Marija and Chen, Feng and Kip, Detlef",
year = "2008",
abstract = "We study theoretically light beam propagation in one-dimensional periodic media with intensity-resonant nonlinearity. The phenomenon of discrete modulational instability is investigated in detail as well as the conditions for the existence and stability of fundamental lattice and surface soliton modes. According to the linear stability analysis, only on-site solitons are stable. The mobility of lattice solitons is analyzed by both free energy and mapping concepts. Only broad solitons may freely traverse the lattice.",
journal = "Physical Review A",
title = "Modulational instability and solitary waves in one-dimensional lattices with intensity-resonant nonlinearity",
volume = "78",
number = "4",
doi = "10.1103/PhysRevA.78.043819"
}

Stepić, M., Maluckov, A., Stojanović, M., Chen, F.,& Kip, D.. (2008). Modulational instability and solitary waves in one-dimensional lattices with intensity-resonant nonlinearity. in Physical Review A, 78(4).
https://doi.org/10.1103/PhysRevA.78.043819

Stepić M, Maluckov A, Stojanović M, Chen F, Kip D. Modulational instability and solitary waves in one-dimensional lattices with intensity-resonant nonlinearity. in Physical Review A. 2008;78(4).
doi:10.1103/PhysRevA.78.043819 .

Stepić, Milutin, Maluckov, Aleksandra, Stojanović, Marija, Chen, Feng, Kip, Detlef, "Modulational instability and solitary waves in one-dimensional lattices with intensity-resonant nonlinearity" in Physical Review A, 78, no. 4 (2008),
https://doi.org/10.1103/PhysRevA.78.043819 . .