TY  - JOUR
AU  - Budimir, Milica
AU  - Marković, Zoran M.
AU  - Vajdak, Jan
AU  - Jovanović, Svetlana P.
AU  - Kubat, Pavel
AU  - Humpoliček, Petr
AU  - Mičušik, Matej
AU  - Danko, Martin
AU  - Barras, Alexandre
AU  - Milivojević, Dušan
AU  - Špitalsky, Zdenko
AU  - Boukherroub, Rabah
AU  - Todorović-Marković, Biljana
PY  - 2021
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/9746
AB  - Persistent microbial contamination of medical implant surfaces is becoming a serious threat to public health. This is principally due to antibiotic-resistant bacterial strains and the formation of bacterial biofilms. The development of novel antibacterial materials that will effectively fight both Gram-positive and Gram-negative bacteria and prevent biofilm formation represents a big challenge for researchers in the last few decades. In the present work, we report an antibacterial hydrophobic carbon quantum dots/polyurethane nanocomposite (hCQD-PU), with enhanced antibacterial properties induced by pre-treatment with gamma-irradiation. Hydrophobic quantum dots (hCQDs), which are capable of generating reactive oxygen species (ROS) upon irradiation with low-power blue light (470 nm), have been integrated into the polyurethane (PU) polymer matrix to form a photoactive nanocomposite. To modify its physical and chemical properties and improve its antibacterial efficacy, various doses of gamma irradiation (1, 10, and 200 kGy) in the air environment were applied to the formed nanocomposite. Gamma-irradiation pre-treatment significantly influenced the rise in ROS production, therefore, the prooxidative activity under the blue-light illumination of hCQD-PU was also significantly improved. The best antibacterial activity was demonstrated by the hCQD-PU nanocomposite irradiated with a dose of 200 kGy, with the complete eradication of Gram-positive Staphylococcus aureus (S. aureus) and Gram-negative Escherichia coli (E. coli) bacteria after 15 min of exposure to the blue lamp. © 2021 Elsevier Ltd
T2  - Radiation Physics and Chemistry
T1  - Enhanced visible light-triggered antibacterial activity of carbon quantum dots/polyurethane nanocomposites by gamma rays induced pre-treatment
VL  - 185
SP  - 109499
DO  - 10.1016/j.radphyschem.2021.109499
ER  - 

@article{
author = "Budimir, Milica and Marković, Zoran M. and Vajdak, Jan and Jovanović, Svetlana P. and Kubat, Pavel and Humpoliček, Petr and Mičušik, Matej and Danko, Martin and Barras, Alexandre and Milivojević, Dušan and Špitalsky, Zdenko and Boukherroub, Rabah and Todorović-Marković, Biljana",
year = "2021",
abstract = "Persistent microbial contamination of medical implant surfaces is becoming a serious threat to public health. This is principally due to antibiotic-resistant bacterial strains and the formation of bacterial biofilms. The development of novel antibacterial materials that will effectively fight both Gram-positive and Gram-negative bacteria and prevent biofilm formation represents a big challenge for researchers in the last few decades. In the present work, we report an antibacterial hydrophobic carbon quantum dots/polyurethane nanocomposite (hCQD-PU), with enhanced antibacterial properties induced by pre-treatment with gamma-irradiation. Hydrophobic quantum dots (hCQDs), which are capable of generating reactive oxygen species (ROS) upon irradiation with low-power blue light (470 nm), have been integrated into the polyurethane (PU) polymer matrix to form a photoactive nanocomposite. To modify its physical and chemical properties and improve its antibacterial efficacy, various doses of gamma irradiation (1, 10, and 200 kGy) in the air environment were applied to the formed nanocomposite. Gamma-irradiation pre-treatment significantly influenced the rise in ROS production, therefore, the prooxidative activity under the blue-light illumination of hCQD-PU was also significantly improved. The best antibacterial activity was demonstrated by the hCQD-PU nanocomposite irradiated with a dose of 200 kGy, with the complete eradication of Gram-positive Staphylococcus aureus (S. aureus) and Gram-negative Escherichia coli (E. coli) bacteria after 15 min of exposure to the blue lamp. © 2021 Elsevier Ltd",
journal = "Radiation Physics and Chemistry",
title = "Enhanced visible light-triggered antibacterial activity of carbon quantum dots/polyurethane nanocomposites by gamma rays induced pre-treatment",
volume = "185",
pages = "109499",
doi = "10.1016/j.radphyschem.2021.109499"
}

Budimir, M., Marković, Z. M., Vajdak, J., Jovanović, S. P., Kubat, P., Humpoliček, P., Mičušik, M., Danko, M., Barras, A., Milivojević, D., Špitalsky, Z., Boukherroub, R.,& Todorović-Marković, B.. (2021). Enhanced visible light-triggered antibacterial activity of carbon quantum dots/polyurethane nanocomposites by gamma rays induced pre-treatment. in Radiation Physics and Chemistry, 185, 109499.
https://doi.org/10.1016/j.radphyschem.2021.109499

Budimir M, Marković ZM, Vajdak J, Jovanović SP, Kubat P, Humpoliček P, Mičušik M, Danko M, Barras A, Milivojević D, Špitalsky Z, Boukherroub R, Todorović-Marković B. Enhanced visible light-triggered antibacterial activity of carbon quantum dots/polyurethane nanocomposites by gamma rays induced pre-treatment. in Radiation Physics and Chemistry. 2021;185:109499.
doi:10.1016/j.radphyschem.2021.109499 .

Budimir, Milica, Marković, Zoran M., Vajdak, Jan, Jovanović, Svetlana P., Kubat, Pavel, Humpoliček, Petr, Mičušik, Matej, Danko, Martin, Barras, Alexandre, Milivojević, Dušan, Špitalsky, Zdenko, Boukherroub, Rabah, Todorović-Marković, Biljana, "Enhanced visible light-triggered antibacterial activity of carbon quantum dots/polyurethane nanocomposites by gamma rays induced pre-treatment" in Radiation Physics and Chemistry, 185 (2021):109499,
https://doi.org/10.1016/j.radphyschem.2021.109499 . .

TY  - JOUR
AU  - Budimir, Milica
AU  - Jijie, Roxana
AU  - Ye, Ran
AU  - Barras, Alexandre
AU  - Melinte, Sorin
AU  - Silhanek, Alejandro
AU  - Marković, Zoran M.
AU  - Szunerits, Sabine
AU  - Boukherroub, Rabah
PY  - 2019
UR  - http://xlink.rsc.org/?DOI=C8TB01676C
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/8181
AB  - Bacterial infections are one of the leading causes of disease worldwide. Conventional antibiotics are becoming less efficient, due to antibiotic-resistant bacterial strains. Therefore, the development of novel antibacterial materials and advanced treatment strategies are becoming increasingly important. In the present work, we developed a simple and efficient strategy for effective bacterial capture and their subsequent eradication through photothermal killing. The developed device consists of a flexible nanoheater, comprising a Kapton/Au nanoholes substrate, coated with reduced graphene oxide-polyethyleneimine (K/Au NH/rGO-PEI) thin films. The Au NH plasmonic structure was tailored to feature strong absorption in the near-infrared (NIR) region, where most biological matter has limited absorption, while PEI was investigated for its strong binding with bacteria through electrostatic interactions. The K/Au NH/rGO-PEI device was demonstrated to capture and eliminate effectively both planktonic Gram-positive Staphilococcus aureus (S. aureus) and Gram-negative Escherichia coli (E. coli) bacteria after 10 min of NIR (980 nm) irradiation and, to destroy and eradicate Staphilococcus epidermidis (S. epidermidis) biofilms after 30 min irradiation. The technique developed herein is simple and universal with potential applications for eradication of different micro-organisms.
T2  - Journal of Materials Chemistry B
T1  - Efficient capture and photothermal ablation of planktonic bacteria and biofilms using reduced graphene oxide–polyethyleneimine flexible nanoheaters
VL  - 7
IS  - 17
SP  - 2771
EP  - 2781
DO  - 10.1039/C8TB01676C
ER  - 

@article{
author = "Budimir, Milica and Jijie, Roxana and Ye, Ran and Barras, Alexandre and Melinte, Sorin and Silhanek, Alejandro and Marković, Zoran M. and Szunerits, Sabine and Boukherroub, Rabah",
year = "2019",
abstract = "Bacterial infections are one of the leading causes of disease worldwide. Conventional antibiotics are becoming less efficient, due to antibiotic-resistant bacterial strains. Therefore, the development of novel antibacterial materials and advanced treatment strategies are becoming increasingly important. In the present work, we developed a simple and efficient strategy for effective bacterial capture and their subsequent eradication through photothermal killing. The developed device consists of a flexible nanoheater, comprising a Kapton/Au nanoholes substrate, coated with reduced graphene oxide-polyethyleneimine (K/Au NH/rGO-PEI) thin films. The Au NH plasmonic structure was tailored to feature strong absorption in the near-infrared (NIR) region, where most biological matter has limited absorption, while PEI was investigated for its strong binding with bacteria through electrostatic interactions. The K/Au NH/rGO-PEI device was demonstrated to capture and eliminate effectively both planktonic Gram-positive Staphilococcus aureus (S. aureus) and Gram-negative Escherichia coli (E. coli) bacteria after 10 min of NIR (980 nm) irradiation and, to destroy and eradicate Staphilococcus epidermidis (S. epidermidis) biofilms after 30 min irradiation. The technique developed herein is simple and universal with potential applications for eradication of different micro-organisms.",
journal = "Journal of Materials Chemistry B",
title = "Efficient capture and photothermal ablation of planktonic bacteria and biofilms using reduced graphene oxide–polyethyleneimine flexible nanoheaters",
volume = "7",
number = "17",
pages = "2771-2781",
doi = "10.1039/C8TB01676C"
}

Budimir, M., Jijie, R., Ye, R., Barras, A., Melinte, S., Silhanek, A., Marković, Z. M., Szunerits, S.,& Boukherroub, R.. (2019). Efficient capture and photothermal ablation of planktonic bacteria and biofilms using reduced graphene oxide–polyethyleneimine flexible nanoheaters. in Journal of Materials Chemistry B, 7(17), 2771-2781.
https://doi.org/10.1039/C8TB01676C

Budimir M, Jijie R, Ye R, Barras A, Melinte S, Silhanek A, Marković ZM, Szunerits S, Boukherroub R. Efficient capture and photothermal ablation of planktonic bacteria and biofilms using reduced graphene oxide–polyethyleneimine flexible nanoheaters. in Journal of Materials Chemistry B. 2019;7(17):2771-2781.
doi:10.1039/C8TB01676C .

Budimir, Milica, Jijie, Roxana, Ye, Ran, Barras, Alexandre, Melinte, Sorin, Silhanek, Alejandro, Marković, Zoran M., Szunerits, Sabine, Boukherroub, Rabah, "Efficient capture and photothermal ablation of planktonic bacteria and biofilms using reduced graphene oxide–polyethyleneimine flexible nanoheaters" in Journal of Materials Chemistry B, 7, no. 17 (2019):2771-2781,
https://doi.org/10.1039/C8TB01676C . .