TY  - CONF
AU  - Drljača, Tamara
AU  - Stevanović, Kristina
AU  - Radošević, Draginja
AU  - Milićević, Jelena S.
AU  - Veljković, Nevena
AU  - Glišić, Sanja
PY  - 2023
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/12243
AB  - Peroxisome proliferator-activated receptor alpha (PPARα) is crucial in regulating lipid metabolism. Clinically, PPARα is significant as a possible therapeutic target for a variety of human disorders, including cardiovascular, neurological, and metabolic syndromes. The wide range of natural compounds provides great opportunities for new approaches in targeting PPARα. Carotenoids, a large class of natural compounds, have been recognized as PPARα agonists. Tomatoes (Solanum lycopersicum) are one of the most widely grown crops in the world and contain compounds that improve lipid metabolism. Since there is no data on tomato carotenoids as PPARα agonists in this study, we focused on searching carotenoids from tomatoes as possible PPARα agonists. The Solanum lycopersicum carotenoids from Carotenoids Database were in silico screened using a combined protocol with the Electron-Ion Interaction Potential/Average Quasi Valence Number (EIIP/AQVN) filter and molecular docking to find the most promising candidate compounds. The best resulting compounds may have the promise to be further developed as candidates for PPARα agonists.
PB  - Kragujevac : Institute for Information Technologies, University of Kragujevac
C3  - ICCBIKG 2023 : 2nd International Conference on Chemo and Bioinformatics : Book of Proceedings
T1  - In silico screening of Solanum lycopersicum carotenoids from Carotenoids Database for candidates PPARα agonists
SP  - 605
EP  - 608
DO  - 10.46793/ICCBI23.605D
ER  - 

@conference{
author = "Drljača, Tamara and Stevanović, Kristina and Radošević, Draginja and Milićević, Jelena S. and Veljković, Nevena and Glišić, Sanja",
year = "2023",
abstract = "Peroxisome proliferator-activated receptor alpha (PPARα) is crucial in regulating lipid metabolism. Clinically, PPARα is significant as a possible therapeutic target for a variety of human disorders, including cardiovascular, neurological, and metabolic syndromes. The wide range of natural compounds provides great opportunities for new approaches in targeting PPARα. Carotenoids, a large class of natural compounds, have been recognized as PPARα agonists. Tomatoes (Solanum lycopersicum) are one of the most widely grown crops in the world and contain compounds that improve lipid metabolism. Since there is no data on tomato carotenoids as PPARα agonists in this study, we focused on searching carotenoids from tomatoes as possible PPARα agonists. The Solanum lycopersicum carotenoids from Carotenoids Database were in silico screened using a combined protocol with the Electron-Ion Interaction Potential/Average Quasi Valence Number (EIIP/AQVN) filter and molecular docking to find the most promising candidate compounds. The best resulting compounds may have the promise to be further developed as candidates for PPARα agonists.",
publisher = "Kragujevac : Institute for Information Technologies, University of Kragujevac",
journal = "ICCBIKG 2023 : 2nd International Conference on Chemo and Bioinformatics : Book of Proceedings",
title = "In silico screening of Solanum lycopersicum carotenoids from Carotenoids Database for candidates PPARα agonists",
pages = "605-608",
doi = "10.46793/ICCBI23.605D"
}

Drljača, T., Stevanović, K., Radošević, D., Milićević, J. S., Veljković, N.,& Glišić, S.. (2023). In silico screening of Solanum lycopersicum carotenoids from Carotenoids Database for candidates PPARα agonists. in ICCBIKG 2023 : 2nd International Conference on Chemo and Bioinformatics : Book of Proceedings
Kragujevac : Institute for Information Technologies, University of Kragujevac., 605-608.
https://doi.org/10.46793/ICCBI23.605D

Drljača T, Stevanović K, Radošević D, Milićević JS, Veljković N, Glišić S. In silico screening of Solanum lycopersicum carotenoids from Carotenoids Database for candidates PPARα agonists. in ICCBIKG 2023 : 2nd International Conference on Chemo and Bioinformatics : Book of Proceedings. 2023;:605-608.
doi:10.46793/ICCBI23.605D .

Drljača, Tamara, Stevanović, Kristina, Radošević, Draginja, Milićević, Jelena S., Veljković, Nevena, Glišić, Sanja, "In silico screening of Solanum lycopersicum carotenoids from Carotenoids Database for candidates PPARα agonists" in ICCBIKG 2023 : 2nd International Conference on Chemo and Bioinformatics : Book of Proceedings (2023):605-608,
https://doi.org/10.46793/ICCBI23.605D . .

TY  - JOUR
AU  - Drljača, Tamara
AU  - Zukić, Branka
AU  - Kovačević, Vladimir
AU  - Gemović, Branislava S.
AU  - Karan-Đurašević, Teodora
AU  - Perović, Vladimir R.
AU  - Lazarević, Mladen
AU  - Pavlović, Sonja
AU  - Veljković, Nevena V.
PY  - 2021
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10769
AB  - The complete understanding of the genomic contribution to complex traits, diseases, and response to treatments, as well as genomic medicine application to the well-being of all humans will be achieved through the global variome that encompasses fine-scale genetic diversity. Despite significant efforts in recent years, uneven representation still characterizes genomic resources and among the underrepresented European populations are the Western Balkans including the Serbian population. Our research addresses this gap and presents the first ever targeted sequencing dataset of variants in clinically relevant genes. By measuring population differentiation and applying the Principal Component and Admixture analysis we demonstrated that the Serbian population differs little from other European populations, yet we identified several novel and more frequent variants that appear as its unique genetic determinants. We explored thoroughly the functional impact of frequent variants and its correlation with the health burden of the population of Serbia based on a sample of 144 individuals. Our variants catalogue improves the understanding of genetics of modern Serbia, contributes to research on ancestry, and aids in improvements of well-being and health equity. In addition, this resource may also be applicable in neighboring regions and valuable in worldwide functional analyses of genetic variants in individuals of European descent.
T2  - Scientific Reports
T1  - The first insight into the genetic structure of the population of modern Serbia
VL  - 11
IS  - 1
SP  - 13995
DO  - 10.1038/s41598-021-93129-4
ER  - 

@article{
author = "Drljača, Tamara and Zukić, Branka and Kovačević, Vladimir and Gemović, Branislava S. and Karan-Đurašević, Teodora and Perović, Vladimir R. and Lazarević, Mladen and Pavlović, Sonja and Veljković, Nevena V.",
year = "2021",
abstract = "The complete understanding of the genomic contribution to complex traits, diseases, and response to treatments, as well as genomic medicine application to the well-being of all humans will be achieved through the global variome that encompasses fine-scale genetic diversity. Despite significant efforts in recent years, uneven representation still characterizes genomic resources and among the underrepresented European populations are the Western Balkans including the Serbian population. Our research addresses this gap and presents the first ever targeted sequencing dataset of variants in clinically relevant genes. By measuring population differentiation and applying the Principal Component and Admixture analysis we demonstrated that the Serbian population differs little from other European populations, yet we identified several novel and more frequent variants that appear as its unique genetic determinants. We explored thoroughly the functional impact of frequent variants and its correlation with the health burden of the population of Serbia based on a sample of 144 individuals. Our variants catalogue improves the understanding of genetics of modern Serbia, contributes to research on ancestry, and aids in improvements of well-being and health equity. In addition, this resource may also be applicable in neighboring regions and valuable in worldwide functional analyses of genetic variants in individuals of European descent.",
journal = "Scientific Reports",
title = "The first insight into the genetic structure of the population of modern Serbia",
volume = "11",
number = "1",
pages = "13995",
doi = "10.1038/s41598-021-93129-4"
}

Drljača, T., Zukić, B., Kovačević, V., Gemović, B. S., Karan-Đurašević, T., Perović, V. R., Lazarević, M., Pavlović, S.,& Veljković, N. V.. (2021). The first insight into the genetic structure of the population of modern Serbia. in Scientific Reports, 11(1), 13995.
https://doi.org/10.1038/s41598-021-93129-4

Drljača T, Zukić B, Kovačević V, Gemović BS, Karan-Đurašević T, Perović VR, Lazarević M, Pavlović S, Veljković NV. The first insight into the genetic structure of the population of modern Serbia. in Scientific Reports. 2021;11(1):13995.
doi:10.1038/s41598-021-93129-4 .

Drljača, Tamara, Zukić, Branka, Kovačević, Vladimir, Gemović, Branislava S., Karan-Đurašević, Teodora, Perović, Vladimir R., Lazarević, Mladen, Pavlović, Sonja, Veljković, Nevena V., "The first insight into the genetic structure of the population of modern Serbia" in Scientific Reports, 11, no. 1 (2021):13995,
https://doi.org/10.1038/s41598-021-93129-4 . .