TY  - JOUR
AU  - Ognjanović, Miloš
AU  - Jaćimović, Željko
AU  - Kosović-Perutović, Milica
AU  - Besu Žižak, Irina
AU  - Stanojković, Tatjana
AU  - Žižak, Željko
AU  - Dojčinović, Biljana
AU  - Stanković, Dalibor M.
AU  - Antić, Bratislav
PY  - 2023
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10733
AB  - Partial cation substitution can significantly change the physical properties of parent compounds. By controlling the chemical composition and knowing the mutual relationship between composition and physical properties, it is possible to tailor the properties of materials to those that are superior for desired technological application. Using the polyol synthesis procedure, a series of yttrium-substituted iron oxide nanoconstructs, γ-Fe2−xYxO3 (YIONs), was prepared. It was found that Y3+ could substitute Fe3+ in the crystal structures of maghemite (γ-Fe2O3) up to a limited concentration of ~1.5% (γ-Fe1.969Y0.031O3). Analysis of TEM micrographs showed that crystallites or particles were aggregated in flower-like structures with diameters from 53.7 ± 6.2 nm to 97.3 ± 37.0 nm, depending on yttrium concentration. To be investigated for potential applications as magnetic hyperthermia agents, YIONs were tested twice: their heating efficiency was tested and their toxicity was investigated. The Specific Absorption Rate (SAR) values were in the range of 32.6 W/g to 513 W/g and significantly decreased with increased yttrium concentration in the samples. Intrinsic loss power (ILP) for γ-Fe2O3 and γ-Fe1.995Y0.005O3 were ~8–9 nH·m2/Kg, which pointed to their excellent heating efficiency. IC50 values of investigated samples against cancer (HeLa) and normal (MRC-5) cells decreased with increased yttrium concentration and were higher than ~300 μg/mL. The samples of γ-Fe2−xYxO3 did not show a genotoxic effect. The results of toxicity studies show that YIONs are suitable for further in vitro/in vivo studies toward to their potential medical applications, while results of heat generation point to their potential use in magnetic hyperthermia cancer treatment or use as self-heating systems for other technological applications such as catalysis.
T2  - Nanomaterials
T1  - Self-Heating Flower-like Nanoconstructs with Limited Incorporation of Yttrium in Maghemite: Effect of Chemical Composition on Heating Efficiency, Cytotoxicity and Genotoxicity
VL  - 13
IS  - 5
SP  - 870
DO  - 10.3390/nano13050870
ER  - 

@article{
author = "Ognjanović, Miloš and Jaćimović, Željko and Kosović-Perutović, Milica and Besu Žižak, Irina and Stanojković, Tatjana and Žižak, Željko and Dojčinović, Biljana and Stanković, Dalibor M. and Antić, Bratislav",
year = "2023",
abstract = "Partial cation substitution can significantly change the physical properties of parent compounds. By controlling the chemical composition and knowing the mutual relationship between composition and physical properties, it is possible to tailor the properties of materials to those that are superior for desired technological application. Using the polyol synthesis procedure, a series of yttrium-substituted iron oxide nanoconstructs, γ-Fe2−xYxO3 (YIONs), was prepared. It was found that Y3+ could substitute Fe3+ in the crystal structures of maghemite (γ-Fe2O3) up to a limited concentration of ~1.5% (γ-Fe1.969Y0.031O3). Analysis of TEM micrographs showed that crystallites or particles were aggregated in flower-like structures with diameters from 53.7 ± 6.2 nm to 97.3 ± 37.0 nm, depending on yttrium concentration. To be investigated for potential applications as magnetic hyperthermia agents, YIONs were tested twice: their heating efficiency was tested and their toxicity was investigated. The Specific Absorption Rate (SAR) values were in the range of 32.6 W/g to 513 W/g and significantly decreased with increased yttrium concentration in the samples. Intrinsic loss power (ILP) for γ-Fe2O3 and γ-Fe1.995Y0.005O3 were ~8–9 nH·m2/Kg, which pointed to their excellent heating efficiency. IC50 values of investigated samples against cancer (HeLa) and normal (MRC-5) cells decreased with increased yttrium concentration and were higher than ~300 μg/mL. The samples of γ-Fe2−xYxO3 did not show a genotoxic effect. The results of toxicity studies show that YIONs are suitable for further in vitro/in vivo studies toward to their potential medical applications, while results of heat generation point to their potential use in magnetic hyperthermia cancer treatment or use as self-heating systems for other technological applications such as catalysis.",
journal = "Nanomaterials",
title = "Self-Heating Flower-like Nanoconstructs with Limited Incorporation of Yttrium in Maghemite: Effect of Chemical Composition on Heating Efficiency, Cytotoxicity and Genotoxicity",
volume = "13",
number = "5",
pages = "870",
doi = "10.3390/nano13050870"
}

Ognjanović, M., Jaćimović, Ž., Kosović-Perutović, M., Besu Žižak, I., Stanojković, T., Žižak, Ž., Dojčinović, B., Stanković, D. M.,& Antić, B.. (2023). Self-Heating Flower-like Nanoconstructs with Limited Incorporation of Yttrium in Maghemite: Effect of Chemical Composition on Heating Efficiency, Cytotoxicity and Genotoxicity. in Nanomaterials, 13(5), 870.
https://doi.org/10.3390/nano13050870

Ognjanović M, Jaćimović Ž, Kosović-Perutović M, Besu Žižak I, Stanojković T, Žižak Ž, Dojčinović B, Stanković DM, Antić B. Self-Heating Flower-like Nanoconstructs with Limited Incorporation of Yttrium in Maghemite: Effect of Chemical Composition on Heating Efficiency, Cytotoxicity and Genotoxicity. in Nanomaterials. 2023;13(5):870.
doi:10.3390/nano13050870 .

Ognjanović, Miloš, Jaćimović, Željko, Kosović-Perutović, Milica, Besu Žižak, Irina, Stanojković, Tatjana, Žižak, Željko, Dojčinović, Biljana, Stanković, Dalibor M., Antić, Bratislav, "Self-Heating Flower-like Nanoconstructs with Limited Incorporation of Yttrium in Maghemite: Effect of Chemical Composition on Heating Efficiency, Cytotoxicity and Genotoxicity" in Nanomaterials, 13, no. 5 (2023):870,
https://doi.org/10.3390/nano13050870 . .

TY  - CONF
AU  - Ognjanović, Miloš
AU  - Dojčinović, Biljana
AU  - Jaćimović, Željko
AU  - Stanković, Dalibor
AU  - Antić, Bratislav
PY  - 2022
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/11663
AB  - Nanomaterials exhibit unique chemical, physical and electronic properties that are different from their bulk counterparts, due to their small size, high surface area and specifically arranged architecture. Nanoscale metal oxides in combination with carbonaceous or other nanomaterials, utilized as modifiers of various types of working electrodes, serve as the basis for the development of electroanalytical procedures for the detection of various compounds. Electrochemical sensors that we are being developed are distinguished by high selectivity, sensitivity, low detection limit and thorough real-world sample analysis. Three types of biosensors: non-enzymatic, enzymatic and immuno-biosensors, were developed. Here we present synthesis nanoplatforms and their applications in electrochemical sensing of various biomolecules: a) (Zn,Fe)3O4 for glucose detections, b) amidase/CeO2/GNR for paracetamol monitoring, c) dandelion-like MnO2 for determination of L-dopa and d) citric acid-capped gallium oxyhydroxide for homocysteine impedimetric immunosensing. The design of these materials was analysed by complementary technics (XRPD, SEM, TEM, SQUID, DLS) to determine their (micro)structural properties and correlate them with electroanalytical performance. During the development, sensors’ overall output had to be assessed in detail, especially real-world sample performance and the capability of potential commercialization. Unique electrochemical sensors based on nanomaterials, developed in our group, open new avenues for the design and fabrication of high-performance sensors with great sensitivity to different biomolecules.
PB  - University in Banjaluka : Faculty of Technology
C3  - 14th Conference of chemists, technologists and environmentalists of Republic of Srpska : the book of abstracts; Oct 21-22, Banja Luka, Republic of Srpska
T1  - Design of nanoplatforms for electrochemical sensing of biomolecules
SP  - 38
UR  - https://hdl.handle.net/21.15107/rcub_vinar_11663
ER  - 

@conference{
author = "Ognjanović, Miloš and Dojčinović, Biljana and Jaćimović, Željko and Stanković, Dalibor and Antić, Bratislav",
year = "2022",
abstract = "Nanomaterials exhibit unique chemical, physical and electronic properties that are different from their bulk counterparts, due to their small size, high surface area and specifically arranged architecture. Nanoscale metal oxides in combination with carbonaceous or other nanomaterials, utilized as modifiers of various types of working electrodes, serve as the basis for the development of electroanalytical procedures for the detection of various compounds. Electrochemical sensors that we are being developed are distinguished by high selectivity, sensitivity, low detection limit and thorough real-world sample analysis. Three types of biosensors: non-enzymatic, enzymatic and immuno-biosensors, were developed. Here we present synthesis nanoplatforms and their applications in electrochemical sensing of various biomolecules: a) (Zn,Fe)3O4 for glucose detections, b) amidase/CeO2/GNR for paracetamol monitoring, c) dandelion-like MnO2 for determination of L-dopa and d) citric acid-capped gallium oxyhydroxide for homocysteine impedimetric immunosensing. The design of these materials was analysed by complementary technics (XRPD, SEM, TEM, SQUID, DLS) to determine their (micro)structural properties and correlate them with electroanalytical performance. During the development, sensors’ overall output had to be assessed in detail, especially real-world sample performance and the capability of potential commercialization. Unique electrochemical sensors based on nanomaterials, developed in our group, open new avenues for the design and fabrication of high-performance sensors with great sensitivity to different biomolecules.",
publisher = "University in Banjaluka : Faculty of Technology",
journal = "14th Conference of chemists, technologists and environmentalists of Republic of Srpska : the book of abstracts; Oct 21-22, Banja Luka, Republic of Srpska",
title = "Design of nanoplatforms for electrochemical sensing of biomolecules",
pages = "38",
url = "https://hdl.handle.net/21.15107/rcub_vinar_11663"
}

Ognjanović, M., Dojčinović, B., Jaćimović, Ž., Stanković, D.,& Antić, B.. (2022). Design of nanoplatforms for electrochemical sensing of biomolecules. in 14th Conference of chemists, technologists and environmentalists of Republic of Srpska : the book of abstracts; Oct 21-22, Banja Luka, Republic of Srpska
University in Banjaluka : Faculty of Technology., 38.
https://hdl.handle.net/21.15107/rcub_vinar_11663

Ognjanović M, Dojčinović B, Jaćimović Ž, Stanković D, Antić B. Design of nanoplatforms for electrochemical sensing of biomolecules. in 14th Conference of chemists, technologists and environmentalists of Republic of Srpska : the book of abstracts; Oct 21-22, Banja Luka, Republic of Srpska. 2022;:38.
https://hdl.handle.net/21.15107/rcub_vinar_11663 .

Ognjanović, Miloš, Dojčinović, Biljana, Jaćimović, Željko, Stanković, Dalibor, Antić, Bratislav, "Design of nanoplatforms for electrochemical sensing of biomolecules" in 14th Conference of chemists, technologists and environmentalists of Republic of Srpska : the book of abstracts; Oct 21-22, Banja Luka, Republic of Srpska (2022):38,
https://hdl.handle.net/21.15107/rcub_vinar_11663 .

TY  - JOUR
AU  - Kosović, Milica
AU  - Novaković, Slađana B.
AU  - Jaćimović, Željko
AU  - Latinović, Nedeljko
AU  - Marković, Nada
AU  - Đorđević, Tamara
AU  - Libowitzky, Eugen
AU  - Giester, Gerald
PY  - 2020
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/9643
AB  - The reaction of 4-nitro-3-pyrazolecarboxylic acid and Cu(OAc)2⋅H2O in ethanol resulted in a new coordination compound [Cu2(4-nitro-3- -pzc)2(H2O)6]2H2O (4nitro-3pzc = 4-nitro-3-pyrazolecarboxylate). The compound was investigated by means of single-crystal X-ray diffraction and infrared spectroscopy. The biological activity of the complex was also tested. In the crystal structure of [Cu2(4nitro-3-pzc)2(H2O)6]2H2O, the Cu(II) ion is in a distorted [4+2] octahedral coordination due to the Jan–Teller effect. A survey of the Cambridge Structural Database showed that the octahedral coordination geometry is generally rare for pyrazole-bridged Cu(II) complexes. In the case of Cu(II) complexes with the 3-pyrazolecarboxylato ligands, no complexes with a similar octahedral coordination geometry have been reported. Biological research based on determination of the inhibition effect of the commercial fungicide Cabrio top and the newly synthesized complex on Ph. viticola were performed using the phytosanitary method.
T2  - Journal of the Serbian Chemical Society
T1  - Synthesis, crystal structure and biological activity of copper(II) complex with 4-nitro-3-pyrazolecarboxylic ligand
VL  - 85
IS  - 7
SP  - 885
EP  - 895
DO  - 10.2298/JSC190724133K
ER  - 

@article{
author = "Kosović, Milica and Novaković, Slađana B. and Jaćimović, Željko and Latinović, Nedeljko and Marković, Nada and Đorđević, Tamara and Libowitzky, Eugen and Giester, Gerald",
year = "2020",
abstract = "The reaction of 4-nitro-3-pyrazolecarboxylic acid and Cu(OAc)2⋅H2O in ethanol resulted in a new coordination compound [Cu2(4-nitro-3- -pzc)2(H2O)6]2H2O (4nitro-3pzc = 4-nitro-3-pyrazolecarboxylate). The compound was investigated by means of single-crystal X-ray diffraction and infrared spectroscopy. The biological activity of the complex was also tested. In the crystal structure of [Cu2(4nitro-3-pzc)2(H2O)6]2H2O, the Cu(II) ion is in a distorted [4+2] octahedral coordination due to the Jan–Teller effect. A survey of the Cambridge Structural Database showed that the octahedral coordination geometry is generally rare for pyrazole-bridged Cu(II) complexes. In the case of Cu(II) complexes with the 3-pyrazolecarboxylato ligands, no complexes with a similar octahedral coordination geometry have been reported. Biological research based on determination of the inhibition effect of the commercial fungicide Cabrio top and the newly synthesized complex on Ph. viticola were performed using the phytosanitary method.",
journal = "Journal of the Serbian Chemical Society",
title = "Synthesis, crystal structure and biological activity of copper(II) complex with 4-nitro-3-pyrazolecarboxylic ligand",
volume = "85",
number = "7",
pages = "885-895",
doi = "10.2298/JSC190724133K"
}

Kosović, M., Novaković, S. B., Jaćimović, Ž., Latinović, N., Marković, N., Đorđević, T., Libowitzky, E.,& Giester, G.. (2020). Synthesis, crystal structure and biological activity of copper(II) complex with 4-nitro-3-pyrazolecarboxylic ligand. in Journal of the Serbian Chemical Society, 85(7), 885-895.
https://doi.org/10.2298/JSC190724133K

Kosović M, Novaković SB, Jaćimović Ž, Latinović N, Marković N, Đorđević T, Libowitzky E, Giester G. Synthesis, crystal structure and biological activity of copper(II) complex with 4-nitro-3-pyrazolecarboxylic ligand. in Journal of the Serbian Chemical Society. 2020;85(7):885-895.
doi:10.2298/JSC190724133K .

Kosović, Milica, Novaković, Slađana B., Jaćimović, Željko, Latinović, Nedeljko, Marković, Nada, Đorđević, Tamara, Libowitzky, Eugen, Giester, Gerald, "Synthesis, crystal structure and biological activity of copper(II) complex with 4-nitro-3-pyrazolecarboxylic ligand" in Journal of the Serbian Chemical Society, 85, no. 7 (2020):885-895,
https://doi.org/10.2298/JSC190724133K . .

TY  - JOUR
AU  - Jaćimović, Željko
AU  - Nedeljko, Latinovic
AU  - Bošković, Ivana V.
AU  - Zoran, Tomic
PY  - 2013
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/5699
AB  - Chemical inhibition of Phomopsis cane and leaf spot disease of grapevine (Phomopsis viticola) has an important practical significance, and it is mainly focused on winter season treatment and beginning of vegatation period of grapevine. Its purpose is to reduce infectious effects of the fungus and to prevent primary infections at the beginning of the vegetation process. This research analysed fungicide activity of the newly synthesized Zn(II) complex with 4-acetyl-3(5)-amino-5(3)-methylpyrazole(Pz1) as ligand and Cu(II) complex with 3,5-dimethyl-1-thiocarbox - amidepyrazole(Pz-CS) as ligand on already mentioned pathogenic fungus that causes Phomopsis cane and leaf spot disease. Observed results are compared with fungicide product Cabrio Top (active substance piraclostrobin belongs to pyrazole derivatives).
T2  - Research Journal of Chemistry and Environment
T1  - The Influence of a Newly Synthesized Zn (II) and Cu (II) Complexes based on Pyrazole Derivatives on the Inhibition of Phomopsis Viticola Sacc. (Sacc.) under Laboratory Conditions
VL  - 17
IS  - 10
SP  - 23
EP  - 27
UR  - https://hdl.handle.net/21.15107/rcub_vinar_5699
ER  - 

@article{
author = "Jaćimović, Željko and Nedeljko, Latinovic and Bošković, Ivana V. and Zoran, Tomic",
year = "2013",
abstract = "Chemical inhibition of Phomopsis cane and leaf spot disease of grapevine (Phomopsis viticola) has an important practical significance, and it is mainly focused on winter season treatment and beginning of vegatation period of grapevine. Its purpose is to reduce infectious effects of the fungus and to prevent primary infections at the beginning of the vegetation process. This research analysed fungicide activity of the newly synthesized Zn(II) complex with 4-acetyl-3(5)-amino-5(3)-methylpyrazole(Pz1) as ligand and Cu(II) complex with 3,5-dimethyl-1-thiocarbox - amidepyrazole(Pz-CS) as ligand on already mentioned pathogenic fungus that causes Phomopsis cane and leaf spot disease. Observed results are compared with fungicide product Cabrio Top (active substance piraclostrobin belongs to pyrazole derivatives).",
journal = "Research Journal of Chemistry and Environment",
title = "The Influence of a Newly Synthesized Zn (II) and Cu (II) Complexes based on Pyrazole Derivatives on the Inhibition of Phomopsis Viticola Sacc. (Sacc.) under Laboratory Conditions",
volume = "17",
number = "10",
pages = "23-27",
url = "https://hdl.handle.net/21.15107/rcub_vinar_5699"
}

Jaćimović, Ž., Nedeljko, L., Bošković, I. V.,& Zoran, T.. (2013). The Influence of a Newly Synthesized Zn (II) and Cu (II) Complexes based on Pyrazole Derivatives on the Inhibition of Phomopsis Viticola Sacc. (Sacc.) under Laboratory Conditions. in Research Journal of Chemistry and Environment, 17(10), 23-27.
https://hdl.handle.net/21.15107/rcub_vinar_5699

Jaćimović Ž, Nedeljko L, Bošković IV, Zoran T. The Influence of a Newly Synthesized Zn (II) and Cu (II) Complexes based on Pyrazole Derivatives on the Inhibition of Phomopsis Viticola Sacc. (Sacc.) under Laboratory Conditions. in Research Journal of Chemistry and Environment. 2013;17(10):23-27.
https://hdl.handle.net/21.15107/rcub_vinar_5699 .

Jaćimović, Željko, Nedeljko, Latinovic, Bošković, Ivana V., Zoran, Tomic, "The Influence of a Newly Synthesized Zn (II) and Cu (II) Complexes based on Pyrazole Derivatives on the Inhibition of Phomopsis Viticola Sacc. (Sacc.) under Laboratory Conditions" in Research Journal of Chemistry and Environment, 17, no. 10 (2013):23-27,
https://hdl.handle.net/21.15107/rcub_vinar_5699 .