TY  - JOUR
AU  - Gussak, Ihor
AU  - Vukajlovic, Dejan
AU  - Vukcevic, Vladan
AU  - George, Samuel
AU  - Bojović, Boško
AU  - Hadžievski, Ljupčo
AU  - Simic, Goran
AU  - Stojanovic, Bojan
AU  - Angelkov, Lazar
AU  - Panescu, Dorin
PY  - 2012
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/4713
AB  - Objective: Atrial fibrillation (AF) surveillance using a wireless handheld monitor capable of 12-lead electrocardiogram reconstruction was performed, and arrhythmia detection rate was compared with serial Holter monitoring. Methods: Twenty-five patients were monitored after an AF ablation procedure using the hand-held monitor for 2 months immediately after and then for 1 month approximately 6 months postablation. All patients underwent 12-lead 24-hour Holter monitoring at 1, 2, and 6 months postablation. Results: During months 1-2, 425 of 2942 hand-held monitor transmissions from 21 of 25 patients showed AF/atrial flutter (Afl). The frequency of detected arrhythmias decreased by month 6 to 85/1128 (P LT .01) in 15 of 23 patients. Hotter monitoring diagnosed AF/Afl in 8 of 25 and 7 of 23 patients at months 1-2 and month 6, respectively (P LT .01 compared with wireless hand-held monitor). Af/Afl diagnosis by wireless monitoring preceded Holler detection by an average of 24 days. Conclusions: Wireless monitoring with 12-lead electrocardiogram reconstruction demonstrated reliable AF/Afl detection that was more sensitive than serial 12-lead 24-hour Holter monitoring. (C) 2012 Elsevier Inc. All rights reserved.
T2  - Journal of Electrocardiology
T1  - Wireless remote monitoring of reconstructed 12-lead ECGs after ablation for atrial fibrillation using a hand-held device
VL  - 45
IS  - 2
SP  - 129
EP  - 135
DO  - 10.1016/j.jelectrocard.2011.09.003
ER  - 

@article{
author = "Gussak, Ihor and Vukajlovic, Dejan and Vukcevic, Vladan and George, Samuel and Bojović, Boško and Hadžievski, Ljupčo and Simic, Goran and Stojanovic, Bojan and Angelkov, Lazar and Panescu, Dorin",
year = "2012",
abstract = "Objective: Atrial fibrillation (AF) surveillance using a wireless handheld monitor capable of 12-lead electrocardiogram reconstruction was performed, and arrhythmia detection rate was compared with serial Holter monitoring. Methods: Twenty-five patients were monitored after an AF ablation procedure using the hand-held monitor for 2 months immediately after and then for 1 month approximately 6 months postablation. All patients underwent 12-lead 24-hour Holter monitoring at 1, 2, and 6 months postablation. Results: During months 1-2, 425 of 2942 hand-held monitor transmissions from 21 of 25 patients showed AF/atrial flutter (Afl). The frequency of detected arrhythmias decreased by month 6 to 85/1128 (P LT .01) in 15 of 23 patients. Hotter monitoring diagnosed AF/Afl in 8 of 25 and 7 of 23 patients at months 1-2 and month 6, respectively (P LT .01 compared with wireless hand-held monitor). Af/Afl diagnosis by wireless monitoring preceded Holler detection by an average of 24 days. Conclusions: Wireless monitoring with 12-lead electrocardiogram reconstruction demonstrated reliable AF/Afl detection that was more sensitive than serial 12-lead 24-hour Holter monitoring. (C) 2012 Elsevier Inc. All rights reserved.",
journal = "Journal of Electrocardiology",
title = "Wireless remote monitoring of reconstructed 12-lead ECGs after ablation for atrial fibrillation using a hand-held device",
volume = "45",
number = "2",
pages = "129-135",
doi = "10.1016/j.jelectrocard.2011.09.003"
}

Gussak, I., Vukajlovic, D., Vukcevic, V., George, S., Bojović, B., Hadžievski, L., Simic, G., Stojanovic, B., Angelkov, L.,& Panescu, D.. (2012). Wireless remote monitoring of reconstructed 12-lead ECGs after ablation for atrial fibrillation using a hand-held device. in Journal of Electrocardiology, 45(2), 129-135.
https://doi.org/10.1016/j.jelectrocard.2011.09.003

Gussak I, Vukajlovic D, Vukcevic V, George S, Bojović B, Hadžievski L, Simic G, Stojanovic B, Angelkov L, Panescu D. Wireless remote monitoring of reconstructed 12-lead ECGs after ablation for atrial fibrillation using a hand-held device. in Journal of Electrocardiology. 2012;45(2):129-135.
doi:10.1016/j.jelectrocard.2011.09.003 .

Gussak, Ihor, Vukajlovic, Dejan, Vukcevic, Vladan, George, Samuel, Bojović, Boško, Hadžievski, Ljupčo, Simic, Goran, Stojanovic, Bojan, Angelkov, Lazar, Panescu, Dorin, "Wireless remote monitoring of reconstructed 12-lead ECGs after ablation for atrial fibrillation using a hand-held device" in Journal of Electrocardiology, 45, no. 2 (2012):129-135,
https://doi.org/10.1016/j.jelectrocard.2011.09.003 . .

TY  - CONF
AU  - Wenzel, Brian J.
AU  - George, Samuel
AU  - Lakkireddy, Dhanunjaya
AU  - Vanga, Subba
AU  - Bommana, Sudha
AU  - Gussak, Ihor
AU  - Simic, Goran
AU  - Bojović, Boško
AU  - Hadžievski, Ljupčo
AU  - Panescu, Dorin
PY  - 2011
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/6936
AB  - Acute myocardial infarction (AMI) diagnosis in type II diabetes (DM2) patients is difficult and ECG findings are often non-diagnostic or inconclusive. We developed computer algorithms to process standard 12-lead ECG input data for quantitative 3-dimensional (3D) analysis (my3KGTM), and hypothesized that use of the my3KGTMs array of over 100 3D-based AMI diagnostic markers may improve diagnostic accuracy for AMI in DM2 patients. Methods: We identified 155 consecutive DM2 patients age GT 25 yrs with chest discomfort or shortness of breath who were evaluated at an urban emergency department (130 patients (pts)) or the cardiac catheterization laboratory (25 pts) for possible AMI. The first digital 12-lead ECG for each patient, obtained within 30 min of presentation, was evaluated by (1) 2 blinded expert cardiologists, and (2) my3KGTM. In each case, the ECG was classified as either likely AMI or likely non-AMI. Gold standard was the final clinical diagnosis. Statistical analysis was McNemars test with continuity correction. Results: The 155 DM2 patients were 50% male, mean age 56.8 +/- 12.0 yrs; 44 pts had a final clinical diagnosis of AMI (17 ST Elevation Myocardial Infarctions (STEMI), 27 Non-ST Elevation Myocardial Infarctions (NSTEMI)) and 111 had no AMI. Conclusions: Relative to standard 12L ECG read by cardiologists, quantitative 3D ECG analysis showed significant and substantial gains in sensitivity for AMI diagnosis in DM2 patients, without loss in specificity. Sensitivity gains were particularly high in patients exhibiting NSTEMI, the most common form of AMI in DM2.
T1  - Algorithm for Quantitative 3 Dimensional Analysis of ECG Signals Improves Myocardial Diagnosis over Cardiologists in Diabetic Patients
SP  - 965
EP  - 968
UR  - https://hdl.handle.net/21.15107/rcub_vinar_6936
ER  - 

@conference{
author = "Wenzel, Brian J. and George, Samuel and Lakkireddy, Dhanunjaya and Vanga, Subba and Bommana, Sudha and Gussak, Ihor and Simic, Goran and Bojović, Boško and Hadžievski, Ljupčo and Panescu, Dorin",
year = "2011",
abstract = "Acute myocardial infarction (AMI) diagnosis in type II diabetes (DM2) patients is difficult and ECG findings are often non-diagnostic or inconclusive. We developed computer algorithms to process standard 12-lead ECG input data for quantitative 3-dimensional (3D) analysis (my3KGTM), and hypothesized that use of the my3KGTMs array of over 100 3D-based AMI diagnostic markers may improve diagnostic accuracy for AMI in DM2 patients. Methods: We identified 155 consecutive DM2 patients age GT 25 yrs with chest discomfort or shortness of breath who were evaluated at an urban emergency department (130 patients (pts)) or the cardiac catheterization laboratory (25 pts) for possible AMI. The first digital 12-lead ECG for each patient, obtained within 30 min of presentation, was evaluated by (1) 2 blinded expert cardiologists, and (2) my3KGTM. In each case, the ECG was classified as either likely AMI or likely non-AMI. Gold standard was the final clinical diagnosis. Statistical analysis was McNemars test with continuity correction. Results: The 155 DM2 patients were 50% male, mean age 56.8 +/- 12.0 yrs; 44 pts had a final clinical diagnosis of AMI (17 ST Elevation Myocardial Infarctions (STEMI), 27 Non-ST Elevation Myocardial Infarctions (NSTEMI)) and 111 had no AMI. Conclusions: Relative to standard 12L ECG read by cardiologists, quantitative 3D ECG analysis showed significant and substantial gains in sensitivity for AMI diagnosis in DM2 patients, without loss in specificity. Sensitivity gains were particularly high in patients exhibiting NSTEMI, the most common form of AMI in DM2.",
title = "Algorithm for Quantitative 3 Dimensional Analysis of ECG Signals Improves Myocardial Diagnosis over Cardiologists in Diabetic Patients",
pages = "965-968",
url = "https://hdl.handle.net/21.15107/rcub_vinar_6936"
}

Wenzel, B. J., George, S., Lakkireddy, D., Vanga, S., Bommana, S., Gussak, I., Simic, G., Bojović, B., Hadžievski, L.,& Panescu, D.. (2011). Algorithm for Quantitative 3 Dimensional Analysis of ECG Signals Improves Myocardial Diagnosis over Cardiologists in Diabetic Patients. , 965-968.
https://hdl.handle.net/21.15107/rcub_vinar_6936

Wenzel BJ, George S, Lakkireddy D, Vanga S, Bommana S, Gussak I, Simic G, Bojović B, Hadžievski L, Panescu D. Algorithm for Quantitative 3 Dimensional Analysis of ECG Signals Improves Myocardial Diagnosis over Cardiologists in Diabetic Patients. 2011;:965-968.
https://hdl.handle.net/21.15107/rcub_vinar_6936 .

Wenzel, Brian J., George, Samuel, Lakkireddy, Dhanunjaya, Vanga, Subba, Bommana, Sudha, Gussak, Ihor, Simic, Goran, Bojović, Boško, Hadžievski, Ljupčo, Panescu, Dorin, "Algorithm for Quantitative 3 Dimensional Analysis of ECG Signals Improves Myocardial Diagnosis over Cardiologists in Diabetic Patients" (2011):965-968,
https://hdl.handle.net/21.15107/rcub_vinar_6936 .

TY  - CONF
AU  - Vukajlovic, Dejan
AU  - Gussak, Ihor
AU  - George, Samuel
AU  - Simic, Goran
AU  - Bojović, Boško
AU  - Hadžievski, Ljupčo
AU  - Stojanovic, Bojan
AU  - Angelkov, Lazar
AU  - Panescu, Dorin
PY  - 2011
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/6937
AB  - Differential diagnosis of symptomatic events in post-ablation atrial fibrillation (AF) patients (pts) is important; in particular, accurate, reliable detection of AF or atrial flutter (AFL) is essential. However, existing remote monitoring devices usually require attached leads and are not suitable for prolonged monitoring; moreover, most do not provide sufficient information to assess atrial activity, since they generally monitor only 1-3 ECG leads and rely on RR interval variability for AF diagnosis. A new hand-held, wireless, symptom-activated event monitor (CardioBip; CB) does not require attached leads and hence can be conveniently used for extended periods. Moreover, CB provides data that enables remote reconstruction of full 12-lead ECG data including atrial signal information. We hypothesized that these CB features would enable accurate remote differential diagnosis of symptomatic arrhythmias in post-ablation AF pts. Methods: 21 pts who underwent catheter ablation for AF were instructed to make a CB transmission (TX) whenever palpitations, lightheadedness, or similar symptoms occurred, and at multiple times daily when asymptomatic, during a 60 day post-ablation time period. CB transmissions (TXs) were analyzed blindly by 2 expert readers, with differences adjudicated by consensus. Results: 7 pts had no symptomatic episodes during the monitoring period. 14 of 21 pts had symptomatic events and made a total of 1699 TX, 164 of which were during symptoms. TX quality was acceptable for rhythm diagnosis and atrial activity in 96%. 118 TX from 10 symptomatic pts showed AF (96 TX from 10 pts) or AFL (22 TX from 3 pts), and 46 TX from 9 pts showed frequent PACs or PVCs. No other arrhythmias were detected. Five pts made symptomatic TX during AF/AFL and also during PACs/PVCs. Conclusions: Use of CB during symptomatic episodes enabled detection and differential diagnosis of symptomatic arrhythmias. The ability of CB to provide accurate reconstruction of 12 L ECGs including atrial activity, combined with its ease of use, makes it suitable for long-term surveillance for recurrent AF in post-ablation patients.
T1  - Wireless Monitoring of Reconstructed 12-Lead ECG in Atrial Fibrillation Patients Enables Differential Diagnosis of Recurrent Arrhythmias
SP  - 4741
EP  - 4744
UR  - https://hdl.handle.net/21.15107/rcub_vinar_6937
ER  - 

@conference{
author = "Vukajlovic, Dejan and Gussak, Ihor and George, Samuel and Simic, Goran and Bojović, Boško and Hadžievski, Ljupčo and Stojanovic, Bojan and Angelkov, Lazar and Panescu, Dorin",
year = "2011",
abstract = "Differential diagnosis of symptomatic events in post-ablation atrial fibrillation (AF) patients (pts) is important; in particular, accurate, reliable detection of AF or atrial flutter (AFL) is essential. However, existing remote monitoring devices usually require attached leads and are not suitable for prolonged monitoring; moreover, most do not provide sufficient information to assess atrial activity, since they generally monitor only 1-3 ECG leads and rely on RR interval variability for AF diagnosis. A new hand-held, wireless, symptom-activated event monitor (CardioBip; CB) does not require attached leads and hence can be conveniently used for extended periods. Moreover, CB provides data that enables remote reconstruction of full 12-lead ECG data including atrial signal information. We hypothesized that these CB features would enable accurate remote differential diagnosis of symptomatic arrhythmias in post-ablation AF pts. Methods: 21 pts who underwent catheter ablation for AF were instructed to make a CB transmission (TX) whenever palpitations, lightheadedness, or similar symptoms occurred, and at multiple times daily when asymptomatic, during a 60 day post-ablation time period. CB transmissions (TXs) were analyzed blindly by 2 expert readers, with differences adjudicated by consensus. Results: 7 pts had no symptomatic episodes during the monitoring period. 14 of 21 pts had symptomatic events and made a total of 1699 TX, 164 of which were during symptoms. TX quality was acceptable for rhythm diagnosis and atrial activity in 96%. 118 TX from 10 symptomatic pts showed AF (96 TX from 10 pts) or AFL (22 TX from 3 pts), and 46 TX from 9 pts showed frequent PACs or PVCs. No other arrhythmias were detected. Five pts made symptomatic TX during AF/AFL and also during PACs/PVCs. Conclusions: Use of CB during symptomatic episodes enabled detection and differential diagnosis of symptomatic arrhythmias. The ability of CB to provide accurate reconstruction of 12 L ECGs including atrial activity, combined with its ease of use, makes it suitable for long-term surveillance for recurrent AF in post-ablation patients.",
title = "Wireless Monitoring of Reconstructed 12-Lead ECG in Atrial Fibrillation Patients Enables Differential Diagnosis of Recurrent Arrhythmias",
pages = "4741-4744",
url = "https://hdl.handle.net/21.15107/rcub_vinar_6937"
}

Vukajlovic, D., Gussak, I., George, S., Simic, G., Bojović, B., Hadžievski, L., Stojanovic, B., Angelkov, L.,& Panescu, D.. (2011). Wireless Monitoring of Reconstructed 12-Lead ECG in Atrial Fibrillation Patients Enables Differential Diagnosis of Recurrent Arrhythmias. , 4741-4744.
https://hdl.handle.net/21.15107/rcub_vinar_6937

Vukajlovic D, Gussak I, George S, Simic G, Bojović B, Hadžievski L, Stojanovic B, Angelkov L, Panescu D. Wireless Monitoring of Reconstructed 12-Lead ECG in Atrial Fibrillation Patients Enables Differential Diagnosis of Recurrent Arrhythmias. 2011;:4741-4744.
https://hdl.handle.net/21.15107/rcub_vinar_6937 .

Vukajlovic, Dejan, Gussak, Ihor, George, Samuel, Simic, Goran, Bojović, Boško, Hadžievski, Ljupčo, Stojanovic, Bojan, Angelkov, Lazar, Panescu, Dorin, "Wireless Monitoring of Reconstructed 12-Lead ECG in Atrial Fibrillation Patients Enables Differential Diagnosis of Recurrent Arrhythmias" (2011):4741-4744,
https://hdl.handle.net/21.15107/rcub_vinar_6937 .

TY  - CONF
AU  - Vukajlovic, Dejan
AU  - Bojović, Boško
AU  - Hadžievski, Ljupčo
AU  - George, Samuel
AU  - Gussak, Ihor
AU  - Panescu, Dorin
PY  - 2010
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/6904
AB  - Remote surveillance is important for patients with atrial fibrillation (AF). Atrial signal recognition with conventional monitoring devices is difficult; remote AF detection is predominantly accomplished by R-R interval analysis. Twelve lead ECG (12L) displays atrial activity and remains the gold standard for AF diagnosis. CardioBip is a portable wireless patient-activated event monitor providing signal reconstruction of a 12L waveform (12CB) using 5 leads and patient-specific transformation matrices. We hypothesized that atrial signal analysis with 12CB can detect atrial activity and improve AF detection. METHODS: 18 patients with AF undergoing DC cardioversion (CV) were studied. Separate 12-lead P and QRS patient-specific transformation matrices were created at baseline AF. Multiple wireless 12CB transmissions were performed 3-7 days before and up to 2 weeks after CV. Rhythm was confirmed with 12-lead ECGs (12L). In SR the number of leads with visible P waves (atrial signal GT 0.05 mV), and P wave polarity were analyzed. In AF, the number of leads with AF signal were compared (fibrillatory [f] waves GT 0.025 mV). RESULTS: Fourteen of 18 patients successfully cardioverted to SR and 4 failed; thus, 14 SR and 22 AF transmissions were analyzed. SR P wave was visible on 141/168 leads on 12L and 137/168 on 12CB (126 true pos [TP] and 11 false pos [FP] relative to 12L; p=0.26). In 126 leads with P waves in both 12L and 12CB, the methods agreed on P wave polarity in 125. In AF, F waves were visible in 178/264 leads on 12L and 189/264 leads on 12CB (144 TP, 45 FP; p=0.27). All 5 AF relapses were successfully detected by 12CB based on atrial activity. CONCLUSION: 12CB is not inferior to 12L in detecting atrial signal in SR and AF, and shows excellent potential for remote wireless monitoring of AF patients.
T1  - Wireless Remote Monitoring of Atrial Fibrillation Using Reconstructed 12-Lead ECGs
SP  - 1113
EP  - 1118
DO  - 10.1109/IEMBS.2010.5627086
ER  - 

@conference{
author = "Vukajlovic, Dejan and Bojović, Boško and Hadžievski, Ljupčo and George, Samuel and Gussak, Ihor and Panescu, Dorin",
year = "2010",
abstract = "Remote surveillance is important for patients with atrial fibrillation (AF). Atrial signal recognition with conventional monitoring devices is difficult; remote AF detection is predominantly accomplished by R-R interval analysis. Twelve lead ECG (12L) displays atrial activity and remains the gold standard for AF diagnosis. CardioBip is a portable wireless patient-activated event monitor providing signal reconstruction of a 12L waveform (12CB) using 5 leads and patient-specific transformation matrices. We hypothesized that atrial signal analysis with 12CB can detect atrial activity and improve AF detection. METHODS: 18 patients with AF undergoing DC cardioversion (CV) were studied. Separate 12-lead P and QRS patient-specific transformation matrices were created at baseline AF. Multiple wireless 12CB transmissions were performed 3-7 days before and up to 2 weeks after CV. Rhythm was confirmed with 12-lead ECGs (12L). In SR the number of leads with visible P waves (atrial signal GT 0.05 mV), and P wave polarity were analyzed. In AF, the number of leads with AF signal were compared (fibrillatory [f] waves GT 0.025 mV). RESULTS: Fourteen of 18 patients successfully cardioverted to SR and 4 failed; thus, 14 SR and 22 AF transmissions were analyzed. SR P wave was visible on 141/168 leads on 12L and 137/168 on 12CB (126 true pos [TP] and 11 false pos [FP] relative to 12L; p=0.26). In 126 leads with P waves in both 12L and 12CB, the methods agreed on P wave polarity in 125. In AF, F waves were visible in 178/264 leads on 12L and 189/264 leads on 12CB (144 TP, 45 FP; p=0.27). All 5 AF relapses were successfully detected by 12CB based on atrial activity. CONCLUSION: 12CB is not inferior to 12L in detecting atrial signal in SR and AF, and shows excellent potential for remote wireless monitoring of AF patients.",
title = "Wireless Remote Monitoring of Atrial Fibrillation Using Reconstructed 12-Lead ECGs",
pages = "1113-1118",
doi = "10.1109/IEMBS.2010.5627086"
}

Vukajlovic, D., Bojović, B., Hadžievski, L., George, S., Gussak, I.,& Panescu, D.. (2010). Wireless Remote Monitoring of Atrial Fibrillation Using Reconstructed 12-Lead ECGs. , 1113-1118.
https://doi.org/10.1109/IEMBS.2010.5627086

Vukajlovic D, Bojović B, Hadžievski L, George S, Gussak I, Panescu D. Wireless Remote Monitoring of Atrial Fibrillation Using Reconstructed 12-Lead ECGs. 2010;:1113-1118.
doi:10.1109/IEMBS.2010.5627086 .

Vukajlovic, Dejan, Bojović, Boško, Hadžievski, Ljupčo, George, Samuel, Gussak, Ihor, Panescu, Dorin, "Wireless Remote Monitoring of Atrial Fibrillation Using Reconstructed 12-Lead ECGs" (2010):1113-1118,
https://doi.org/10.1109/IEMBS.2010.5627086 . .