TY  - CONF
AU  - Čolović, Mirjana B.
AU  - Ma, Tian
AU  - Ma, Xiang
AU  - Isaković, Anđelka
AU  - Misirlić-Denčić, Sonja
AU  - Kortz, Urlich
AU  - Krstić, Danijela
PY  - 2021
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/13019
AB  - Polyoxopalladates(II) (POPs) are the largest subset of polyoxo-noble-metalates (PONMs), representing a class of discrete, anionic noble metal-oxo nanoclusters. In this study, the in vitro effects of two isostructural, fully inorganic POP salts containing tetravalent metal ions (SnIV and PbIV) incorporated inside the cubic Pd12-oxo host-shell, Na12[SnIVO8Pd12(PO4)8]·43H2O (SnPd12) and Na12[PbIVO8Pd12(PO4)8]·38H2O (PbPd12), which were found to exhibit considerable antileukemic effects, on E-NTPDase activity were investigated using rat synaptic plasma membranes (SPMs) as a model system. Concentration-dependent inhibition of E-NTPDases was observed within the concentration range 5 × 10-6 - 2 × 10-4 mol/L for both POPs. Inhibition parameters, half-maximum inhibitory concentrations (IC50 values) and Hill's coefficients, nH, were determined by sigmoidal fitting the experimental results and Hill's analysis. The calculated IC50 values were (6.59 ± 1.09) × 10-5 and (9.88 ± 3.83) × 10-5 mol/L for SnPd12 and PbPd12, respectively. The calculated nH values were < 1, indicating negatively cooperative enzyme-inhibitor binding for both POPs. Accordingly, the confirmed antileukemic activities of SnPd12 and PbPd12 could be associated with the observed inhibition of E-NTPDases as a potential target of the antileukemic action of these promising drug candidates.
PB  - Belgrade : Society of Physical Chemists of Serbia
C3  - PHYSICAL CHEMISTRY 2021 : 15th international conference on fundamental and applied aspects of physical chemistry : Book of abstracts
T1  - Inhibition of ecto-nucleoside triphosphate diphosphohydrolases by polyoxopalladates with promising antileukemic properties
SP  - 78
EP  - 78
UR  - https://hdl.handle.net/21.15107/rcub_vinar_13019
ER  - 

@conference{
author = "Čolović, Mirjana B. and Ma, Tian and Ma, Xiang and Isaković, Anđelka and Misirlić-Denčić, Sonja and Kortz, Urlich and Krstić, Danijela",
year = "2021",
abstract = "Polyoxopalladates(II) (POPs) are the largest subset of polyoxo-noble-metalates (PONMs), representing a class of discrete, anionic noble metal-oxo nanoclusters. In this study, the in vitro effects of two isostructural, fully inorganic POP salts containing tetravalent metal ions (SnIV and PbIV) incorporated inside the cubic Pd12-oxo host-shell, Na12[SnIVO8Pd12(PO4)8]·43H2O (SnPd12) and Na12[PbIVO8Pd12(PO4)8]·38H2O (PbPd12), which were found to exhibit considerable antileukemic effects, on E-NTPDase activity were investigated using rat synaptic plasma membranes (SPMs) as a model system. Concentration-dependent inhibition of E-NTPDases was observed within the concentration range 5 × 10-6 - 2 × 10-4 mol/L for both POPs. Inhibition parameters, half-maximum inhibitory concentrations (IC50 values) and Hill's coefficients, nH, were determined by sigmoidal fitting the experimental results and Hill's analysis. The calculated IC50 values were (6.59 ± 1.09) × 10-5 and (9.88 ± 3.83) × 10-5 mol/L for SnPd12 and PbPd12, respectively. The calculated nH values were < 1, indicating negatively cooperative enzyme-inhibitor binding for both POPs. Accordingly, the confirmed antileukemic activities of SnPd12 and PbPd12 could be associated with the observed inhibition of E-NTPDases as a potential target of the antileukemic action of these promising drug candidates.",
publisher = "Belgrade : Society of Physical Chemists of Serbia",
journal = "PHYSICAL CHEMISTRY 2021 : 15th international conference on fundamental and applied aspects of physical chemistry : Book of abstracts",
title = "Inhibition of ecto-nucleoside triphosphate diphosphohydrolases by polyoxopalladates with promising antileukemic properties",
pages = "78-78",
url = "https://hdl.handle.net/21.15107/rcub_vinar_13019"
}

Čolović, M. B., Ma, T., Ma, X., Isaković, A., Misirlić-Denčić, S., Kortz, U.,& Krstić, D.. (2021). Inhibition of ecto-nucleoside triphosphate diphosphohydrolases by polyoxopalladates with promising antileukemic properties. in PHYSICAL CHEMISTRY 2021 : 15th international conference on fundamental and applied aspects of physical chemistry : Book of abstracts
Belgrade : Society of Physical Chemists of Serbia., 78-78.
https://hdl.handle.net/21.15107/rcub_vinar_13019

Čolović MB, Ma T, Ma X, Isaković A, Misirlić-Denčić S, Kortz U, Krstić D. Inhibition of ecto-nucleoside triphosphate diphosphohydrolases by polyoxopalladates with promising antileukemic properties. in PHYSICAL CHEMISTRY 2021 : 15th international conference on fundamental and applied aspects of physical chemistry : Book of abstracts. 2021;:78-78.
https://hdl.handle.net/21.15107/rcub_vinar_13019 .

Čolović, Mirjana B., Ma, Tian, Ma, Xiang, Isaković, Anđelka, Misirlić-Denčić, Sonja, Kortz, Urlich, Krstić, Danijela, "Inhibition of ecto-nucleoside triphosphate diphosphohydrolases by polyoxopalladates with promising antileukemic properties" in PHYSICAL CHEMISTRY 2021 : 15th international conference on fundamental and applied aspects of physical chemistry : Book of abstracts (2021):78-78,
https://hdl.handle.net/21.15107/rcub_vinar_13019 .