TY  - CONF
AU  - Todorović, Nevena
AU  - Stevanović, Jelena
AU  - Filipović, Dragana
PY  - 2014
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/9267
AB  - Chronic psychosocial stress is a risk factor for depression. As the liver is a
primary organ for drug activation and detoxification, the effect of chronic
administration of olanzapine on rat hepatic glutathione (GSH)-dependent
defense system including GSH, glutathione peroxidase (GPx) and
glutathione reductase (GLR), following 21d of chronic social isolation stress
(CSIS), an animal model of depression, was investigated. Increased GSH
content in olanzapine-treated controls was found. Protein levels of GPx
were increased in both vehicle- and olanzapine-treated chronically-isolated
animals while significant increase in GPx activity was seen only in
olanzapine-treated chronically-isolated animals. Reduced activity of GLR in
CSIS group that was not in correspondence with its protein level was
increased by olanzapine. The results imply that chronic administration of
olanzapine reverts the alternations in hepatic GSH-dependent defense of
stressed rats caused by CSIS.
PB  - Society of Physical Chemists of Serbia
C3  - Physical chemistry 2014: 12th International Conference on Fundamental and Applied Aspects of Physical Chemistry
T1  - Olanzapine reverts the isolation-induced alterations in rat hepatic glutathione-dependent defense system
VL  - Q-05-P
UR  - https://hdl.handle.net/21.15107/rcub_vinar_9267
ER  - 

@conference{
author = "Todorović, Nevena and Stevanović, Jelena and Filipović, Dragana",
year = "2014",
abstract = "Chronic psychosocial stress is a risk factor for depression. As the liver is a
primary organ for drug activation and detoxification, the effect of chronic
administration of olanzapine on rat hepatic glutathione (GSH)-dependent
defense system including GSH, glutathione peroxidase (GPx) and
glutathione reductase (GLR), following 21d of chronic social isolation stress
(CSIS), an animal model of depression, was investigated. Increased GSH
content in olanzapine-treated controls was found. Protein levels of GPx
were increased in both vehicle- and olanzapine-treated chronically-isolated
animals while significant increase in GPx activity was seen only in
olanzapine-treated chronically-isolated animals. Reduced activity of GLR in
CSIS group that was not in correspondence with its protein level was
increased by olanzapine. The results imply that chronic administration of
olanzapine reverts the alternations in hepatic GSH-dependent defense of
stressed rats caused by CSIS.",
publisher = "Society of Physical Chemists of Serbia",
journal = "Physical chemistry 2014: 12th International Conference on Fundamental and Applied Aspects of Physical Chemistry",
title = "Olanzapine reverts the isolation-induced alterations in rat hepatic glutathione-dependent defense system",
volume = "Q-05-P",
url = "https://hdl.handle.net/21.15107/rcub_vinar_9267"
}

Todorović, N., Stevanović, J.,& Filipović, D.. (2014). Olanzapine reverts the isolation-induced alterations in rat hepatic glutathione-dependent defense system. in Physical chemistry 2014: 12th International Conference on Fundamental and Applied Aspects of Physical Chemistry
Society of Physical Chemists of Serbia., Q-05-P.
https://hdl.handle.net/21.15107/rcub_vinar_9267

Todorović N, Stevanović J, Filipović D. Olanzapine reverts the isolation-induced alterations in rat hepatic glutathione-dependent defense system. in Physical chemistry 2014: 12th International Conference on Fundamental and Applied Aspects of Physical Chemistry. 2014;Q-05-P.
https://hdl.handle.net/21.15107/rcub_vinar_9267 .

Todorović, Nevena, Stevanović, Jelena, Filipović, Dragana, "Olanzapine reverts the isolation-induced alterations in rat hepatic glutathione-dependent defense system" in Physical chemistry 2014: 12th International Conference on Fundamental and Applied Aspects of Physical Chemistry, Q-05-P (2014),
https://hdl.handle.net/21.15107/rcub_vinar_9267 .