TY  - CONF
AU  - Nikolić, Dragana
AU  - Stanković, Srboljub
AU  - Kovačević, Ana
AU  - Dabetić, Marina
PY  - 2020
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/12160
AB  - Investigation of a CBRN incident has to be conducted in a systematic, objective, and timely manner in order to collect, preserve and analyse physical evidence from the associated site to be admissible in a criminal or civil proceeding, as well as in prosecution of acts of terrorism and war crimes. The inherently hazardous character of a crime scene involving CBRN agents adds complexity to investigative actions and requires additional expertise, equipment and conditions. The specific investigation strategies are necessary, together with the adapted CBRN detection equipment and forensics methods and procedures. This paper deals with the management of a CBRN crime scene and the specifics of investigation process, including interfaces between CBRN safety and security, and emergency response. The necessary framework, the conduct of operations, and an integrated command structure are outlined. The role of the technical support organisations with adequate CBRN expertises is emphasised.
PB  - Belgrade : RASEC : Regional Association for Security and Crisis Management
C3  - SAFETY FOR FUTURE 2020 : 6th International Scientific and Professional Conference “Security and Crises Management– Theory and Practice SeCMan 2020” : Proceedings
T1  - CBRN crime scene management and investigation
SP  - 248
EP  - 256
UR  - https://hdl.handle.net/21.15107/rcub_vinar_12160
ER  - 

@conference{
author = "Nikolić, Dragana and Stanković, Srboljub and Kovačević, Ana and Dabetić, Marina",
year = "2020",
abstract = "Investigation of a CBRN incident has to be conducted in a systematic, objective, and timely manner in order to collect, preserve and analyse physical evidence from the associated site to be admissible in a criminal or civil proceeding, as well as in prosecution of acts of terrorism and war crimes. The inherently hazardous character of a crime scene involving CBRN agents adds complexity to investigative actions and requires additional expertise, equipment and conditions. The specific investigation strategies are necessary, together with the adapted CBRN detection equipment and forensics methods and procedures. This paper deals with the management of a CBRN crime scene and the specifics of investigation process, including interfaces between CBRN safety and security, and emergency response. The necessary framework, the conduct of operations, and an integrated command structure are outlined. The role of the technical support organisations with adequate CBRN expertises is emphasised.",
publisher = "Belgrade : RASEC : Regional Association for Security and Crisis Management",
journal = "SAFETY FOR FUTURE 2020 : 6th International Scientific and Professional Conference “Security and Crises Management– Theory and Practice SeCMan 2020” : Proceedings",
title = "CBRN crime scene management and investigation",
pages = "248-256",
url = "https://hdl.handle.net/21.15107/rcub_vinar_12160"
}

Nikolić, D., Stanković, S., Kovačević, A.,& Dabetić, M.. (2020). CBRN crime scene management and investigation. in SAFETY FOR FUTURE 2020 : 6th International Scientific and Professional Conference “Security and Crises Management– Theory and Practice SeCMan 2020” : Proceedings
Belgrade : RASEC : Regional Association for Security and Crisis Management., 248-256.
https://hdl.handle.net/21.15107/rcub_vinar_12160

Nikolić D, Stanković S, Kovačević A, Dabetić M. CBRN crime scene management and investigation. in SAFETY FOR FUTURE 2020 : 6th International Scientific and Professional Conference “Security and Crises Management– Theory and Practice SeCMan 2020” : Proceedings. 2020;:248-256.
https://hdl.handle.net/21.15107/rcub_vinar_12160 .

Nikolić, Dragana, Stanković, Srboljub, Kovačević, Ana, Dabetić, Marina, "CBRN crime scene management and investigation" in SAFETY FOR FUTURE 2020 : 6th International Scientific and Professional Conference “Security and Crises Management– Theory and Practice SeCMan 2020” : Proceedings (2020):248-256,
https://hdl.handle.net/21.15107/rcub_vinar_12160 .

TY  - CONF
AU  - Stanković, Srboljub
AU  - Ilić, Radovan
AU  - Marinković, Predrag
AU  - Nikolić, Dragana
AU  - Kržanović, Nikola
AU  - Radenković, Mirjana
PY  - 2019
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/12139
AB  - During the construction of nuclear facilities, radiotherapy centers, hospitals with radiological diagnostic facilities, and radioactive waste storage facilities, complex requirements for protection against ionizing radiation have been set up. In its basic principles, modern approaches in the design of radiation protection procedures were derived from empirical conclusions that were obtained by solving practical problems encountered by nuclear engineers and physicists. In the radiation protection projections, as well as in the formation of different technical and technological procedures in the radiation environment, one of the most important characteristics is the build-up factor of the material used. Based on experimental and theoretical research, empirical formulas for calculating the build-up factors are used to solve practical problems in radiation protection. With the development of information and computer technologies for calculating the build-up factor, other numerical methods are also used, of which a very attractive and efficient Monte Carlo calculation method is used. In this paper, the calculations with the empirical approximate formulas by Taylor and Berger, as well as the results obtained by using the software based on the Monte Carlo method, were used to determine the build-up of the factors in the protection of gamma and X radiation for several selected materials (lead, water, iron, etc.). By comparing the results obtained with the empirical approximations and Monte Carlo calculations, certain conclusions have been drawn that direct us to new critical considerations about the usefulness of using the chosen method of calculation for the build-up factor of materials found in modern technological processes using sources of gamma and X radiation.
PB  - Niš : Sievert Association
C3  - RAP 2019 : International conference on radiation applications : Book of abstracts
T1  - Application of the Monte Carlo method and the empirical approximate formulas by Taylor and Berger for the calculation of the build-up factor in the fields of gamma and X radiation
SP  - 93
EP  - 93
UR  - https://hdl.handle.net/21.15107/rcub_vinar_12139
ER  - 

@conference{
author = "Stanković, Srboljub and Ilić, Radovan and Marinković, Predrag and Nikolić, Dragana and Kržanović, Nikola and Radenković, Mirjana",
year = "2019",
abstract = "During the construction of nuclear facilities, radiotherapy centers, hospitals with radiological diagnostic facilities, and radioactive waste storage facilities, complex requirements for protection against ionizing radiation have been set up. In its basic principles, modern approaches in the design of radiation protection procedures were derived from empirical conclusions that were obtained by solving practical problems encountered by nuclear engineers and physicists. In the radiation protection projections, as well as in the formation of different technical and technological procedures in the radiation environment, one of the most important characteristics is the build-up factor of the material used. Based on experimental and theoretical research, empirical formulas for calculating the build-up factors are used to solve practical problems in radiation protection. With the development of information and computer technologies for calculating the build-up factor, other numerical methods are also used, of which a very attractive and efficient Monte Carlo calculation method is used. In this paper, the calculations with the empirical approximate formulas by Taylor and Berger, as well as the results obtained by using the software based on the Monte Carlo method, were used to determine the build-up of the factors in the protection of gamma and X radiation for several selected materials (lead, water, iron, etc.). By comparing the results obtained with the empirical approximations and Monte Carlo calculations, certain conclusions have been drawn that direct us to new critical considerations about the usefulness of using the chosen method of calculation for the build-up factor of materials found in modern technological processes using sources of gamma and X radiation.",
publisher = "Niš : Sievert Association",
journal = "RAP 2019 : International conference on radiation applications : Book of abstracts",
title = "Application of the Monte Carlo method and the empirical approximate formulas by Taylor and Berger for the calculation of the build-up factor in the fields of gamma and X radiation",
pages = "93-93",
url = "https://hdl.handle.net/21.15107/rcub_vinar_12139"
}

Stanković, S., Ilić, R., Marinković, P., Nikolić, D., Kržanović, N.,& Radenković, M.. (2019). Application of the Monte Carlo method and the empirical approximate formulas by Taylor and Berger for the calculation of the build-up factor in the fields of gamma and X radiation. in RAP 2019 : International conference on radiation applications : Book of abstracts
Niš : Sievert Association., 93-93.
https://hdl.handle.net/21.15107/rcub_vinar_12139

Stanković S, Ilić R, Marinković P, Nikolić D, Kržanović N, Radenković M. Application of the Monte Carlo method and the empirical approximate formulas by Taylor and Berger for the calculation of the build-up factor in the fields of gamma and X radiation. in RAP 2019 : International conference on radiation applications : Book of abstracts. 2019;:93-93.
https://hdl.handle.net/21.15107/rcub_vinar_12139 .

Stanković, Srboljub, Ilić, Radovan, Marinković, Predrag, Nikolić, Dragana, Kržanović, Nikola, Radenković, Mirjana, "Application of the Monte Carlo method and the empirical approximate formulas by Taylor and Berger for the calculation of the build-up factor in the fields of gamma and X radiation" in RAP 2019 : International conference on radiation applications : Book of abstracts (2019):93-93,
https://hdl.handle.net/21.15107/rcub_vinar_12139 .

TY  - CHAP
AU  - Nikolić, Dragana
AU  - Stanković, Srboljub
PY  - 2019
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/12142
PB  - Beograd : Evroazijski bezbednosni forum
T2  - Posledice NATO agresije na SRJ 1999. : dve decenije posle
T1  - Određivanje posledica upotrebe osiromašenog uranijuma – problemi i mogućnosti
SP  - 143
EP  - 172
UR  - https://hdl.handle.net/21.15107/rcub_vinar_12142
ER  - 

@inbook{
author = "Nikolić, Dragana and Stanković, Srboljub",
year = "2019",
publisher = "Beograd : Evroazijski bezbednosni forum",
journal = "Posledice NATO agresije na SRJ 1999. : dve decenije posle",
booktitle = "Određivanje posledica upotrebe osiromašenog uranijuma – problemi i mogućnosti",
pages = "143-172",
url = "https://hdl.handle.net/21.15107/rcub_vinar_12142"
}

Nikolić, D.,& Stanković, S.. (2019). Određivanje posledica upotrebe osiromašenog uranijuma – problemi i mogućnosti. in Posledice NATO agresije na SRJ 1999. : dve decenije posle
Beograd : Evroazijski bezbednosni forum., 143-172.
https://hdl.handle.net/21.15107/rcub_vinar_12142

Nikolić D, Stanković S. Određivanje posledica upotrebe osiromašenog uranijuma – problemi i mogućnosti. in Posledice NATO agresije na SRJ 1999. : dve decenije posle. 2019;:143-172.
https://hdl.handle.net/21.15107/rcub_vinar_12142 .

Nikolić, Dragana, Stanković, Srboljub, "Određivanje posledica upotrebe osiromašenog uranijuma – problemi i mogućnosti" in Posledice NATO agresije na SRJ 1999. : dve decenije posle (2019):143-172,
https://hdl.handle.net/21.15107/rcub_vinar_12142 .

TY  - CONF
AU  - Stanković, Srboljub
AU  - Nikolić, Dragana
AU  - Kržanović, Nikola
AU  - Nađđerđ, Laslo
AU  - Davidović, Vojkan S.
PY  - 2019
UR  - https://ieeexplore.ieee.org/document/8889613/
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/8659
AB  - The paper presents the application of a numerical method for the determination of the absorbed dose rate of gamma and X radiation in the dielectric thin layer of hafnium dioxide (RfO2) or SiO2, which is located in the structure of the MOS capacitor. Considering the radiation characteristics of the selected dielectrics, it can be concluded that there are advantages of RfO2 over SiO2 in the radiation field with high-energy X-rays. Similar radiation effects should be expected for the interaction of dielectric material with gamma ray photons originating from a Co-60 source, both in the dielectric layer with SiO2 and in that with RfO2. It can be concluded that for the same radiation absorbed dose into the MOS capacitor with RfO2, there are a greater number of generated electron-hole pairs, in which case the value of effective trapping efficiency is smaller than if SiO2 was used. © 2019 IEEE.
PB  - IEEE
C3  - IEEE : 31st International Conference on Microelectronics (MIEL) : Book of proceedings
T1  - Comparison of Radiation Characteristics of HfO2 and SiO2 Incorporated in MOS Capacitor in Field of Gamma and X Radiation
SP  - 181
EP  - 184
DO  - 10.1109/MIEL.2019.8889613
ER  - 

@conference{
author = "Stanković, Srboljub and Nikolić, Dragana and Kržanović, Nikola and Nađđerđ, Laslo and Davidović, Vojkan S.",
year = "2019",
abstract = "The paper presents the application of a numerical method for the determination of the absorbed dose rate of gamma and X radiation in the dielectric thin layer of hafnium dioxide (RfO2) or SiO2, which is located in the structure of the MOS capacitor. Considering the radiation characteristics of the selected dielectrics, it can be concluded that there are advantages of RfO2 over SiO2 in the radiation field with high-energy X-rays. Similar radiation effects should be expected for the interaction of dielectric material with gamma ray photons originating from a Co-60 source, both in the dielectric layer with SiO2 and in that with RfO2. It can be concluded that for the same radiation absorbed dose into the MOS capacitor with RfO2, there are a greater number of generated electron-hole pairs, in which case the value of effective trapping efficiency is smaller than if SiO2 was used. © 2019 IEEE.",
publisher = "IEEE",
journal = "IEEE : 31st International Conference on Microelectronics (MIEL) : Book of proceedings",
title = "Comparison of Radiation Characteristics of HfO2 and SiO2 Incorporated in MOS Capacitor in Field of Gamma and X Radiation",
pages = "181-184",
doi = "10.1109/MIEL.2019.8889613"
}

Stanković, S., Nikolić, D., Kržanović, N., Nađđerđ, L.,& Davidović, V. S.. (2019). Comparison of Radiation Characteristics of HfO2 and SiO2 Incorporated in MOS Capacitor in Field of Gamma and X Radiation. in IEEE : 31st International Conference on Microelectronics (MIEL) : Book of proceedings
IEEE., 181-184.
https://doi.org/10.1109/MIEL.2019.8889613

Stanković S, Nikolić D, Kržanović N, Nađđerđ L, Davidović VS. Comparison of Radiation Characteristics of HfO2 and SiO2 Incorporated in MOS Capacitor in Field of Gamma and X Radiation. in IEEE : 31st International Conference on Microelectronics (MIEL) : Book of proceedings. 2019;:181-184.
doi:10.1109/MIEL.2019.8889613 .

Stanković, Srboljub, Nikolić, Dragana, Kržanović, Nikola, Nađđerđ, Laslo, Davidović, Vojkan S., "Comparison of Radiation Characteristics of HfO2 and SiO2 Incorporated in MOS Capacitor in Field of Gamma and X Radiation" in IEEE : 31st International Conference on Microelectronics (MIEL) : Book of proceedings (2019):181-184,
https://doi.org/10.1109/MIEL.2019.8889613 . .

TY  - CONF
AU  - Stanković, Srboljub
AU  - Jakšić, Aleksandar
AU  - Lončar, Boris B.
AU  - Nikolić, Dragana
AU  - Radenković, Mirjana
PY  - 2019
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/11148
PB  - RAD Centre, Niš, Serbia
C3  - RAD 2019 : 7th International Conference on Radiation in Various Fields of Research : book of abstracts; June 10-14, 2019; Herceg Novi, Montenegro
T1  - One numerical method for determining the absorbed dose of gamma and X radiation in the ZrO2 dielectric within the MOS capacitor
SP  - 197
EP  - 
UR  - https://hdl.handle.net/21.15107/rcub_vinar_11148
ER  - 

@conference{
author = "Stanković, Srboljub and Jakšić, Aleksandar and Lončar, Boris B. and Nikolić, Dragana and Radenković, Mirjana",
year = "2019",
publisher = "RAD Centre, Niš, Serbia",
journal = "RAD 2019 : 7th International Conference on Radiation in Various Fields of Research : book of abstracts; June 10-14, 2019; Herceg Novi, Montenegro",
title = "One numerical method for determining the absorbed dose of gamma and X radiation in the ZrO2 dielectric within the MOS capacitor",
pages = "197-",
url = "https://hdl.handle.net/21.15107/rcub_vinar_11148"
}

Stanković, S., Jakšić, A., Lončar, B. B., Nikolić, D.,& Radenković, M.. (2019). One numerical method for determining the absorbed dose of gamma and X radiation in the ZrO2 dielectric within the MOS capacitor. in RAD 2019 : 7th International Conference on Radiation in Various Fields of Research : book of abstracts; June 10-14, 2019; Herceg Novi, Montenegro
RAD Centre, Niš, Serbia., 197-.
https://hdl.handle.net/21.15107/rcub_vinar_11148

Stanković S, Jakšić A, Lončar BB, Nikolić D, Radenković M. One numerical method for determining the absorbed dose of gamma and X radiation in the ZrO2 dielectric within the MOS capacitor. in RAD 2019 : 7th International Conference on Radiation in Various Fields of Research : book of abstracts; June 10-14, 2019; Herceg Novi, Montenegro. 2019;:197-.
https://hdl.handle.net/21.15107/rcub_vinar_11148 .

Stanković, Srboljub, Jakšić, Aleksandar, Lončar, Boris B., Nikolić, Dragana, Radenković, Mirjana, "One numerical method for determining the absorbed dose of gamma and X radiation in the ZrO2 dielectric within the MOS capacitor" in RAD 2019 : 7th International Conference on Radiation in Various Fields of Research : book of abstracts; June 10-14, 2019; Herceg Novi, Montenegro (2019):197-,
https://hdl.handle.net/21.15107/rcub_vinar_11148 .

TY  - CONF
AU  - Stanković, Srboljub
AU  - Jakšić, Aleksandar
AU  - Radenković, Mirjana
AU  - Nikolić, Dragana
AU  - Kržanović, Nikola
PY  - 2018
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/11190
PB  - RAD Centre, Niš, Serbia
C3  - RAD 2018 : 6th International Conference on Radiation in Various Fields of Research : book of abstracts; June 18-22, 2018; Ohrid, Macedonia
T1  - Radiation characteristics for HFO2 and SIO2 incorporated in electronic component with mos structure in fields of gamma and x-radiation
SP  - 247
UR  - https://hdl.handle.net/21.15107/rcub_vinar_11190
ER  - 

@conference{
author = "Stanković, Srboljub and Jakšić, Aleksandar and Radenković, Mirjana and Nikolić, Dragana and Kržanović, Nikola",
year = "2018",
publisher = "RAD Centre, Niš, Serbia",
journal = "RAD 2018 : 6th International Conference on Radiation in Various Fields of Research : book of abstracts; June 18-22, 2018; Ohrid, Macedonia",
title = "Radiation characteristics for HFO2 and SIO2 incorporated in electronic component with mos structure in fields of gamma and x-radiation",
pages = "247",
url = "https://hdl.handle.net/21.15107/rcub_vinar_11190"
}

Stanković, S., Jakšić, A., Radenković, M., Nikolić, D.,& Kržanović, N.. (2018). Radiation characteristics for HFO2 and SIO2 incorporated in electronic component with mos structure in fields of gamma and x-radiation. in RAD 2018 : 6th International Conference on Radiation in Various Fields of Research : book of abstracts; June 18-22, 2018; Ohrid, Macedonia
RAD Centre, Niš, Serbia., 247.
https://hdl.handle.net/21.15107/rcub_vinar_11190

Stanković S, Jakšić A, Radenković M, Nikolić D, Kržanović N. Radiation characteristics for HFO2 and SIO2 incorporated in electronic component with mos structure in fields of gamma and x-radiation. in RAD 2018 : 6th International Conference on Radiation in Various Fields of Research : book of abstracts; June 18-22, 2018; Ohrid, Macedonia. 2018;:247.
https://hdl.handle.net/21.15107/rcub_vinar_11190 .

Stanković, Srboljub, Jakšić, Aleksandar, Radenković, Mirjana, Nikolić, Dragana, Kržanović, Nikola, "Radiation characteristics for HFO2 and SIO2 incorporated in electronic component with mos structure in fields of gamma and x-radiation" in RAD 2018 : 6th International Conference on Radiation in Various Fields of Research : book of abstracts; June 18-22, 2018; Ohrid, Macedonia (2018):247,
https://hdl.handle.net/21.15107/rcub_vinar_11190 .

TY  - CONF
AU  - Stanković, Srboljub
AU  - Jakšić, Aleksandar
AU  - Ilić, Radovan
AU  - Nikolić, Dragana
AU  - Lončar, Boris
AU  - Lazarević, Đorđe
AU  - Karadžić, Katarina
PY  - 2015
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/12151
AB  - MOSFET electronic components are already the subject of several decades of research in various fields of dosimetry and radiation protection. Special interest appeared when these components are started to be used as dosimeters in radiotherapy with electron beams. However, if one looks much more serious in the wider scientific research horizon, all the results obtained in experiments with precisely defined energies of incident electrons can be used in other disciplines which consider the impacts spectra of cosmic radiation on electronic devices, which is especially importance for cosmic science and space research instrumentation. In this paper, one of the objectives was to examine the electrical characteristics specially designed ESAPMOS RADFET dosimeters in the experiments that were conducted on a linear accelerator installations. RADFET components are bombarded electron beams energy of 6 MeV and 8 MeV, and then are followed by changes in threshold voltage shift mean values depending on the change of absorbed dose is referred to as D(cGy) was determined in water. Conclusions performance RADFET components are more than encouraging in terms of further research to improve the linearity of the energy dependence as widely energy electrons. In the second part of the test complex structure of packaging components RADFET focus is placed on the determination of the energy deposited in layers that are of interest for the analysis of microscopic processes related to the recombination of radiation-induced electron-hole pairs. Transport incident electrons through all the layers of structure RADFET component type ESAPMOS was carried out numerical simulations of the Monte Carlo method using the software package FOTELP-2K12. On this occasion, were taken into account all the physical processes of interaction of electrons with materials given structure. When he conquered the numerical application of mathematical and physical model for determining the value of the absorbed energy as the energy deposited per unit mass in a given layers with different materials, it could be accessed defining physical shielding factor (PSF) for a given structure RADFET components. Physical shielding factor (PSF) is defined as the ratio of absorbed dose values, which in fact means that it is equal to the energy deposited when the RADFET is shielded with protection, and the RADFET without lid. When we know the energy dependence factor for PSF of RADFET with and without armour, can be carried out and the analysis of whether and to what extent the energy required compensating the electronic components. Monte Carlo simulations were performed for the transport of incident electrons from 4 MeV, 6 MeV, 8 MeV and 12 MeV. It can be concluded that the different energy of incident electrons there is a significant influence of material Kovar on the absorbed energy in SiO2 and Si layers structure RADFET, in cases where Kovar used among other things as physical protection.
PB  - Niš : RAD Association
C3  - RAD 2015 : International Conference on Radiation and Applications in Various Fields of Research : Book of abstracts
T1  - Experiments with RADFET dosimeter in electron-beams irradiation and numerical computation of the physical shielding factor
SP  - 153
EP  - 153
UR  - https://hdl.handle.net/21.15107/rcub_vinar_12151
ER  - 

@conference{
author = "Stanković, Srboljub and Jakšić, Aleksandar and Ilić, Radovan and Nikolić, Dragana and Lončar, Boris and Lazarević, Đorđe and Karadžić, Katarina",
year = "2015",
abstract = "MOSFET electronic components are already the subject of several decades of research in various fields of dosimetry and radiation protection. Special interest appeared when these components are started to be used as dosimeters in radiotherapy with electron beams. However, if one looks much more serious in the wider scientific research horizon, all the results obtained in experiments with precisely defined energies of incident electrons can be used in other disciplines which consider the impacts spectra of cosmic radiation on electronic devices, which is especially importance for cosmic science and space research instrumentation. In this paper, one of the objectives was to examine the electrical characteristics specially designed ESAPMOS RADFET dosimeters in the experiments that were conducted on a linear accelerator installations. RADFET components are bombarded electron beams energy of 6 MeV and 8 MeV, and then are followed by changes in threshold voltage shift mean values depending on the change of absorbed dose is referred to as D(cGy) was determined in water. Conclusions performance RADFET components are more than encouraging in terms of further research to improve the linearity of the energy dependence as widely energy electrons. In the second part of the test complex structure of packaging components RADFET focus is placed on the determination of the energy deposited in layers that are of interest for the analysis of microscopic processes related to the recombination of radiation-induced electron-hole pairs. Transport incident electrons through all the layers of structure RADFET component type ESAPMOS was carried out numerical simulations of the Monte Carlo method using the software package FOTELP-2K12. On this occasion, were taken into account all the physical processes of interaction of electrons with materials given structure. When he conquered the numerical application of mathematical and physical model for determining the value of the absorbed energy as the energy deposited per unit mass in a given layers with different materials, it could be accessed defining physical shielding factor (PSF) for a given structure RADFET components. Physical shielding factor (PSF) is defined as the ratio of absorbed dose values, which in fact means that it is equal to the energy deposited when the RADFET is shielded with protection, and the RADFET without lid. When we know the energy dependence factor for PSF of RADFET with and without armour, can be carried out and the analysis of whether and to what extent the energy required compensating the electronic components. Monte Carlo simulations were performed for the transport of incident electrons from 4 MeV, 6 MeV, 8 MeV and 12 MeV. It can be concluded that the different energy of incident electrons there is a significant influence of material Kovar on the absorbed energy in SiO2 and Si layers structure RADFET, in cases where Kovar used among other things as physical protection.",
publisher = "Niš : RAD Association",
journal = "RAD 2015 : International Conference on Radiation and Applications in Various Fields of Research : Book of abstracts",
title = "Experiments with RADFET dosimeter in electron-beams irradiation and numerical computation of the physical shielding factor",
pages = "153-153",
url = "https://hdl.handle.net/21.15107/rcub_vinar_12151"
}

Stanković, S., Jakšić, A., Ilić, R., Nikolić, D., Lončar, B., Lazarević, Đ.,& Karadžić, K.. (2015). Experiments with RADFET dosimeter in electron-beams irradiation and numerical computation of the physical shielding factor. in RAD 2015 : International Conference on Radiation and Applications in Various Fields of Research : Book of abstracts
Niš : RAD Association., 153-153.
https://hdl.handle.net/21.15107/rcub_vinar_12151

Stanković S, Jakšić A, Ilić R, Nikolić D, Lončar B, Lazarević Đ, Karadžić K. Experiments with RADFET dosimeter in electron-beams irradiation and numerical computation of the physical shielding factor. in RAD 2015 : International Conference on Radiation and Applications in Various Fields of Research : Book of abstracts. 2015;:153-153.
https://hdl.handle.net/21.15107/rcub_vinar_12151 .

Stanković, Srboljub, Jakšić, Aleksandar, Ilić, Radovan, Nikolić, Dragana, Lončar, Boris, Lazarević, Đorđe, Karadžić, Katarina, "Experiments with RADFET dosimeter in electron-beams irradiation and numerical computation of the physical shielding factor" in RAD 2015 : International Conference on Radiation and Applications in Various Fields of Research : Book of abstracts (2015):153-153,
https://hdl.handle.net/21.15107/rcub_vinar_12151 .

TY  - JOUR
AU  - Rizzo, Manfredi
AU  - Abate, Nicola
AU  - Chandalia, Manisha
AU  - Rizvi, Ali A.
AU  - Giglio, Rosaria V.
AU  - Nikolić, Dragana
AU  - Gammazza, Antonella Marino
AU  - Barbagallo, Ignazio
AU  - Isenović, Esma R.
AU  - Banach, Maciej
AU  - Montalto, Giuseppe
AU  - Volti, Giovanni Li
PY  - 2015
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/508
AB  - Context: Liraglutide is a glucagon-like peptide-1 analog and glucose-lowering agent whose effects on cardiovascular risk markers have not been fully elucidated. Objective: We evaluated the effect of liraglutide on markers of oxidative stress, heme oxygenase-1 (HO-1), and plasma ghrelin levels in patients with type-2 diabetes mellitus (T2DM). Design and Setting: A prospective pilot study of 2 months duration has been performed at the Unit of Diabetes and Cardiovascular Prevention at University of Palermo, Italy. Patients and Intervention(s): Twenty subjects with T2DM (10 men and 10 women; meanage: 57 +/- 13 y) were treated with liraglutide sc (0.6 mg/d for 2 wk, followed by 1.2 mg/d) in addition to metformin (1500 mg/d orally) for 2 months. Patients with liver disorders or renal failure were excluded. Main Outcome Measure(s): Plasma ghrelin concentrations, oxidative stress markers, and heat-shock proteins, including HO-1 were assessed. Results: The addition of liraglutide resulted in a significant decrease in glycated hemoglobin (HbA1c) (8.5 +/- 0.4 vs 7.5 +/- 0.4%, P LT .0001). In addition, plasma ghrelin and glutathione concentrations increased (8.2 +/- 4.1 vs 13.6 +/- 7.3 pg/ml, P = .0007 and 0.36 +/- 0.06 vs 0.44 +/- 0.07 nmol/ml, P = .0002, respectively), whereas serum lipid hydroperoxides and HO-1 decreased (0.11 +/- 0.05 vs 0.04 +/- 0.07 pg/ml, P = .0487 and 7.7 +/- 7.7 vs 3.6 +/- 1.8 pg/ml, P = .0445, respectively). These changes were not correlated with changes in fasting glycemia or HbA1c. Conclusions: In a 2-months prospective pilot study, the addition of liraglutide to metformin resulted in improvement in oxidative stress as well as plasma ghrelin and HO-1 concentrations in patients with T2DM. These findings seemed to be independent of the known effects of liraglutide on glucose metabolism.
T2  - Journal of Clinical Endocrinology and Metabolism
T1  - Liraglutide Reduces Oxidative Stress And Restores Heme Oxygenase-1 and Ghrelin Levels in Patients with Type 2 Diabetes: A Prospective Pilot Study
VL  - 100
IS  - 2
SP  - 603
EP  - 606
DO  - 10.1210/jc.2014-2291
ER  - 

@article{
author = "Rizzo, Manfredi and Abate, Nicola and Chandalia, Manisha and Rizvi, Ali A. and Giglio, Rosaria V. and Nikolić, Dragana and Gammazza, Antonella Marino and Barbagallo, Ignazio and Isenović, Esma R. and Banach, Maciej and Montalto, Giuseppe and Volti, Giovanni Li",
year = "2015",
abstract = "Context: Liraglutide is a glucagon-like peptide-1 analog and glucose-lowering agent whose effects on cardiovascular risk markers have not been fully elucidated. Objective: We evaluated the effect of liraglutide on markers of oxidative stress, heme oxygenase-1 (HO-1), and plasma ghrelin levels in patients with type-2 diabetes mellitus (T2DM). Design and Setting: A prospective pilot study of 2 months duration has been performed at the Unit of Diabetes and Cardiovascular Prevention at University of Palermo, Italy. Patients and Intervention(s): Twenty subjects with T2DM (10 men and 10 women; meanage: 57 +/- 13 y) were treated with liraglutide sc (0.6 mg/d for 2 wk, followed by 1.2 mg/d) in addition to metformin (1500 mg/d orally) for 2 months. Patients with liver disorders or renal failure were excluded. Main Outcome Measure(s): Plasma ghrelin concentrations, oxidative stress markers, and heat-shock proteins, including HO-1 were assessed. Results: The addition of liraglutide resulted in a significant decrease in glycated hemoglobin (HbA1c) (8.5 +/- 0.4 vs 7.5 +/- 0.4%, P LT .0001). In addition, plasma ghrelin and glutathione concentrations increased (8.2 +/- 4.1 vs 13.6 +/- 7.3 pg/ml, P = .0007 and 0.36 +/- 0.06 vs 0.44 +/- 0.07 nmol/ml, P = .0002, respectively), whereas serum lipid hydroperoxides and HO-1 decreased (0.11 +/- 0.05 vs 0.04 +/- 0.07 pg/ml, P = .0487 and 7.7 +/- 7.7 vs 3.6 +/- 1.8 pg/ml, P = .0445, respectively). These changes were not correlated with changes in fasting glycemia or HbA1c. Conclusions: In a 2-months prospective pilot study, the addition of liraglutide to metformin resulted in improvement in oxidative stress as well as plasma ghrelin and HO-1 concentrations in patients with T2DM. These findings seemed to be independent of the known effects of liraglutide on glucose metabolism.",
journal = "Journal of Clinical Endocrinology and Metabolism",
title = "Liraglutide Reduces Oxidative Stress And Restores Heme Oxygenase-1 and Ghrelin Levels in Patients with Type 2 Diabetes: A Prospective Pilot Study",
volume = "100",
number = "2",
pages = "603-606",
doi = "10.1210/jc.2014-2291"
}

Rizzo, M., Abate, N., Chandalia, M., Rizvi, A. A., Giglio, R. V., Nikolić, D., Gammazza, A. M., Barbagallo, I., Isenović, E. R., Banach, M., Montalto, G.,& Volti, G. L.. (2015). Liraglutide Reduces Oxidative Stress And Restores Heme Oxygenase-1 and Ghrelin Levels in Patients with Type 2 Diabetes: A Prospective Pilot Study. in Journal of Clinical Endocrinology and Metabolism, 100(2), 603-606.
https://doi.org/10.1210/jc.2014-2291

Rizzo M, Abate N, Chandalia M, Rizvi AA, Giglio RV, Nikolić D, Gammazza AM, Barbagallo I, Isenović ER, Banach M, Montalto G, Volti GL. Liraglutide Reduces Oxidative Stress And Restores Heme Oxygenase-1 and Ghrelin Levels in Patients with Type 2 Diabetes: A Prospective Pilot Study. in Journal of Clinical Endocrinology and Metabolism. 2015;100(2):603-606.
doi:10.1210/jc.2014-2291 .

Rizzo, Manfredi, Abate, Nicola, Chandalia, Manisha, Rizvi, Ali A., Giglio, Rosaria V., Nikolić, Dragana, Gammazza, Antonella Marino, Barbagallo, Ignazio, Isenović, Esma R., Banach, Maciej, Montalto, Giuseppe, Volti, Giovanni Li, "Liraglutide Reduces Oxidative Stress And Restores Heme Oxygenase-1 and Ghrelin Levels in Patients with Type 2 Diabetes: A Prospective Pilot Study" in Journal of Clinical Endocrinology and Metabolism, 100, no. 2 (2015):603-606,
https://doi.org/10.1210/jc.2014-2291 . .

TY  - JOUR
AU  - Abate, Nicola
AU  - Sallam, Hanaa S.
AU  - Rizzo, Manfredi
AU  - Nikolić, Dragana
AU  - Obradović, Milan M.
AU  - Bjelogrlic, Predrag
AU  - Isenović, Esma R.
PY  - 2014
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/56
AB  - Resistin is an adipocyte-and monocyte-derived cytokine which has been implicated in the modulation of insulin action, energy, glucose and lipid homeostasis. Resistin has been associated with insulin resistance and many of its known complications. As a molecular link between metabolic signals, inflammation, and vascular dysfunction, resistin can be proposed as playing a significant role in the heightened inflammatory state induced by metabolic stress linked to excessive caloric intake, thus contributing to the risk for metabolic syndrome (MetS), type 2 diabetes (T2DM), and cardiovascular diseases (CVD). In this review, we highlighted the role of resistin, as an inflammatory cytokine, in the development of CVD, T2DM and the MetS.
T2  - Current Pharmaceutical Design
T1  - Resistin: An Inflammatory Cytokine. Role in Cardiovascular Diseases, Diabetes and the Metabolic Syndrome
VL  - 20
IS  - 31
SP  - 4961
EP  - 4969
UR  - https://hdl.handle.net/21.15107/rcub_vinar_56
ER  - 

@article{
author = "Abate, Nicola and Sallam, Hanaa S. and Rizzo, Manfredi and Nikolić, Dragana and Obradović, Milan M. and Bjelogrlic, Predrag and Isenović, Esma R.",
year = "2014",
abstract = "Resistin is an adipocyte-and monocyte-derived cytokine which has been implicated in the modulation of insulin action, energy, glucose and lipid homeostasis. Resistin has been associated with insulin resistance and many of its known complications. As a molecular link between metabolic signals, inflammation, and vascular dysfunction, resistin can be proposed as playing a significant role in the heightened inflammatory state induced by metabolic stress linked to excessive caloric intake, thus contributing to the risk for metabolic syndrome (MetS), type 2 diabetes (T2DM), and cardiovascular diseases (CVD). In this review, we highlighted the role of resistin, as an inflammatory cytokine, in the development of CVD, T2DM and the MetS.",
journal = "Current Pharmaceutical Design",
title = "Resistin: An Inflammatory Cytokine. Role in Cardiovascular Diseases, Diabetes and the Metabolic Syndrome",
volume = "20",
number = "31",
pages = "4961-4969",
url = "https://hdl.handle.net/21.15107/rcub_vinar_56"
}

Abate, N., Sallam, H. S., Rizzo, M., Nikolić, D., Obradović, M. M., Bjelogrlic, P.,& Isenović, E. R.. (2014). Resistin: An Inflammatory Cytokine. Role in Cardiovascular Diseases, Diabetes and the Metabolic Syndrome. in Current Pharmaceutical Design, 20(31), 4961-4969.
https://hdl.handle.net/21.15107/rcub_vinar_56

Abate N, Sallam HS, Rizzo M, Nikolić D, Obradović MM, Bjelogrlic P, Isenović ER. Resistin: An Inflammatory Cytokine. Role in Cardiovascular Diseases, Diabetes and the Metabolic Syndrome. in Current Pharmaceutical Design. 2014;20(31):4961-4969.
https://hdl.handle.net/21.15107/rcub_vinar_56 .

Abate, Nicola, Sallam, Hanaa S., Rizzo, Manfredi, Nikolić, Dragana, Obradović, Milan M., Bjelogrlic, Predrag, Isenović, Esma R., "Resistin: An Inflammatory Cytokine. Role in Cardiovascular Diseases, Diabetes and the Metabolic Syndrome" in Current Pharmaceutical Design, 20, no. 31 (2014):4961-4969,
https://hdl.handle.net/21.15107/rcub_vinar_56 .

TY  - JOUR
AU  - Rizzo, Manfredi
AU  - Obradović, Milan M.
AU  - Labudović-Borović, Milica
AU  - Nikolić, Dragana
AU  - Montalto, Giuseppe
AU  - Rizvi, Ali A.
AU  - Mikhailidis, Dimitri P.
AU  - Isenović, Esma R.
PY  - 2014
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/290
AB  - In humans uric acid (UA) is the end product of degradation of purines. The handling of UA by the renal system is a complex process which is not fully understood. To date, several urate transporters in the renal proximal tubule have been identified. Among them, urate transporter 1 (URAT1) and a glucose transporter 9 (GLUT9) are considered of greater importance, as potential targets for treatment of hyperuricemia and the potential associated cardio-metabolic risk. Therefore, the recognition of the metabolic pathway of UA and elucidation of occurrence of hyperuricemia may provide important insights about the relationship between UA, pre-hypertension (preHT) and the metabolic syndrome (MetS). We also review the available clinical studies in this field, including experimental studies dealing with the mechanisms of UA transport via different transporters, as well as current treatment options for hyperuricemia in patients with MetS, preHT or cardiovascular risk factors.
T2  - Current Vascular Pharmacology
T1  - Uric Acid Metabolism in Pre-hypertension and the Metabolic Syndrome
VL  - 12
IS  - 4
SP  - 572
EP  - 585
DO  - 10.2174/1570161111999131205160756
ER  - 

@article{
author = "Rizzo, Manfredi and Obradović, Milan M. and Labudović-Borović, Milica and Nikolić, Dragana and Montalto, Giuseppe and Rizvi, Ali A. and Mikhailidis, Dimitri P. and Isenović, Esma R.",
year = "2014",
abstract = "In humans uric acid (UA) is the end product of degradation of purines. The handling of UA by the renal system is a complex process which is not fully understood. To date, several urate transporters in the renal proximal tubule have been identified. Among them, urate transporter 1 (URAT1) and a glucose transporter 9 (GLUT9) are considered of greater importance, as potential targets for treatment of hyperuricemia and the potential associated cardio-metabolic risk. Therefore, the recognition of the metabolic pathway of UA and elucidation of occurrence of hyperuricemia may provide important insights about the relationship between UA, pre-hypertension (preHT) and the metabolic syndrome (MetS). We also review the available clinical studies in this field, including experimental studies dealing with the mechanisms of UA transport via different transporters, as well as current treatment options for hyperuricemia in patients with MetS, preHT or cardiovascular risk factors.",
journal = "Current Vascular Pharmacology",
title = "Uric Acid Metabolism in Pre-hypertension and the Metabolic Syndrome",
volume = "12",
number = "4",
pages = "572-585",
doi = "10.2174/1570161111999131205160756"
}

Rizzo, M., Obradović, M. M., Labudović-Borović, M., Nikolić, D., Montalto, G., Rizvi, A. A., Mikhailidis, D. P.,& Isenović, E. R.. (2014). Uric Acid Metabolism in Pre-hypertension and the Metabolic Syndrome. in Current Vascular Pharmacology, 12(4), 572-585.
https://doi.org/10.2174/1570161111999131205160756

Rizzo M, Obradović MM, Labudović-Borović M, Nikolić D, Montalto G, Rizvi AA, Mikhailidis DP, Isenović ER. Uric Acid Metabolism in Pre-hypertension and the Metabolic Syndrome. in Current Vascular Pharmacology. 2014;12(4):572-585.
doi:10.2174/1570161111999131205160756 .

Rizzo, Manfredi, Obradović, Milan M., Labudović-Borović, Milica, Nikolić, Dragana, Montalto, Giuseppe, Rizvi, Ali A., Mikhailidis, Dimitri P., Isenović, Esma R., "Uric Acid Metabolism in Pre-hypertension and the Metabolic Syndrome" in Current Vascular Pharmacology, 12, no. 4 (2014):572-585,
https://doi.org/10.2174/1570161111999131205160756 . .

TY  - CHAP
AU  - Nikolić, Dragana
AU  - Kovačević, Ana
AU  - Stanković, Srboljub
PY  - 2013
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/12144
PB  - Beograd : Faculty of Security Studies
PB  - Ljubljana : Institute for Corporative Security Studies
T2  - National Critical Infrastructure Protection Regional Perspective
T1  - Threat Assessment for the Design of the Effective Protection System for Nuclear Facilities
SP  - 315
EP  - 336
UR  - https://hdl.handle.net/21.15107/rcub_vinar_12144
ER  - 

@inbook{
author = "Nikolić, Dragana and Kovačević, Ana and Stanković, Srboljub",
year = "2013",
publisher = "Beograd : Faculty of Security Studies, Ljubljana : Institute for Corporative Security Studies",
journal = "National Critical Infrastructure Protection Regional Perspective",
booktitle = "Threat Assessment for the Design of the Effective Protection System for Nuclear Facilities",
pages = "315-336",
url = "https://hdl.handle.net/21.15107/rcub_vinar_12144"
}

Nikolić, D., Kovačević, A.,& Stanković, S.. (2013). Threat Assessment for the Design of the Effective Protection System for Nuclear Facilities. in National Critical Infrastructure Protection Regional Perspective
Beograd : Faculty of Security Studies., 315-336.
https://hdl.handle.net/21.15107/rcub_vinar_12144

Nikolić D, Kovačević A, Stanković S. Threat Assessment for the Design of the Effective Protection System for Nuclear Facilities. in National Critical Infrastructure Protection Regional Perspective. 2013;:315-336.
https://hdl.handle.net/21.15107/rcub_vinar_12144 .

Nikolić, Dragana, Kovačević, Ana, Stanković, Srboljub, "Threat Assessment for the Design of the Effective Protection System for Nuclear Facilities" in National Critical Infrastructure Protection Regional Perspective (2013):315-336,
https://hdl.handle.net/21.15107/rcub_vinar_12144 .

TY  - CONF
AU  - Nikolić, Dragana
AU  - Kovačević, Ana
AU  - Stanković, Srboljub
PY  - 2013
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/12145
AB  - Nuclear installations, such as nuclear power plants, research reactors, reprocessing facilities and other components of the nuclear fuel cycle, including the transport between these sites, are among the most critical infrastructures not only for their importance in the energy sector, but also because of the severity and the extent of the potential consequences in case of accidents involving nuclear and other radioactive materials. The possible threat ranges from extreme natural occurrences (such as earthquakes, tornadoes, flooding), failures of structures and components, installation internal type events and human errors, to unauthorized removal of nuclear material and malicious acts intended to cause damage, culminating with terrorist attack. Some of these threats are primarily taken into account in safety analysis, while others are in the focus of security assessment. Although nuclear safety and security regimes have a different focus, they overlap with each other and have a common objective - to prevent radiological damage to population, property and the environment, and to avoid negative economic effects and social disruption. Therefore, establishing and maintaining effective protection of nuclear installations and nuclear material is a complex task that requires careful evaluation of risks and consideration of both safety and security measures for risk prevention and mitigation of the consequences. This paper is focused on nuclear security systems and arrangements for the protection of nuclear installations, nuclear and other radioactive material. In particular, a threat assessment process and methodology for the development, use and maintaining of the Design Basis Threat (DBT) are presented. The whole process is based upon a risk managed and threat-driven approach. DBT represents the largest reasonable threat that a facility should expect to defend against. It is an important tool used to determine well-specified threat levels, providing a representative set of attributes and characteristics of potential adversaries (internal and/ or external). Since the DBT also provides detailed and precise technical foundations for the design and evaluation criteria for a physical protection system, the margins of achieving the adequate degree of assurance that the level of protection is sufficient are explored. Some common principles of nuclear safety and nuclear security are outlined in this paper and the importance of their correlation for efficient protection of nuclear facilities is discussed. The conclusion reached is that, in the context of the increased focus on defences against terrorists at nuclear facilities, the new, extended approach to analysis of the beyond DBT events is needed, to include more severe attacks as well as combination of the different types of threats. In addition, the application of more stringent requirements for physical protection and promoting of nuclear security culture at all levels of nuclear security regime is recommended.
PB  - Belgrade : University of Belgrade, Faculty of Security Studies
C3  - International conference "National Critical Infrastructure Protection - Regional Perspective" : Book of abstracts
T1  - Threat Assessment for the Design of the Effective Protection System for Nuclear Installations
SP  - 51
EP  - 52
UR  - https://hdl.handle.net/21.15107/rcub_vinar_12145
ER  - 

@conference{
author = "Nikolić, Dragana and Kovačević, Ana and Stanković, Srboljub",
year = "2013",
abstract = "Nuclear installations, such as nuclear power plants, research reactors, reprocessing facilities and other components of the nuclear fuel cycle, including the transport between these sites, are among the most critical infrastructures not only for their importance in the energy sector, but also because of the severity and the extent of the potential consequences in case of accidents involving nuclear and other radioactive materials. The possible threat ranges from extreme natural occurrences (such as earthquakes, tornadoes, flooding), failures of structures and components, installation internal type events and human errors, to unauthorized removal of nuclear material and malicious acts intended to cause damage, culminating with terrorist attack. Some of these threats are primarily taken into account in safety analysis, while others are in the focus of security assessment. Although nuclear safety and security regimes have a different focus, they overlap with each other and have a common objective - to prevent radiological damage to population, property and the environment, and to avoid negative economic effects and social disruption. Therefore, establishing and maintaining effective protection of nuclear installations and nuclear material is a complex task that requires careful evaluation of risks and consideration of both safety and security measures for risk prevention and mitigation of the consequences. This paper is focused on nuclear security systems and arrangements for the protection of nuclear installations, nuclear and other radioactive material. In particular, a threat assessment process and methodology for the development, use and maintaining of the Design Basis Threat (DBT) are presented. The whole process is based upon a risk managed and threat-driven approach. DBT represents the largest reasonable threat that a facility should expect to defend against. It is an important tool used to determine well-specified threat levels, providing a representative set of attributes and characteristics of potential adversaries (internal and/ or external). Since the DBT also provides detailed and precise technical foundations for the design and evaluation criteria for a physical protection system, the margins of achieving the adequate degree of assurance that the level of protection is sufficient are explored. Some common principles of nuclear safety and nuclear security are outlined in this paper and the importance of their correlation for efficient protection of nuclear facilities is discussed. The conclusion reached is that, in the context of the increased focus on defences against terrorists at nuclear facilities, the new, extended approach to analysis of the beyond DBT events is needed, to include more severe attacks as well as combination of the different types of threats. In addition, the application of more stringent requirements for physical protection and promoting of nuclear security culture at all levels of nuclear security regime is recommended.",
publisher = "Belgrade : University of Belgrade, Faculty of Security Studies",
journal = "International conference "National Critical Infrastructure Protection - Regional Perspective" : Book of abstracts",
title = "Threat Assessment for the Design of the Effective Protection System for Nuclear Installations",
pages = "51-52",
url = "https://hdl.handle.net/21.15107/rcub_vinar_12145"
}

Nikolić, D., Kovačević, A.,& Stanković, S.. (2013). Threat Assessment for the Design of the Effective Protection System for Nuclear Installations. in International conference "National Critical Infrastructure Protection - Regional Perspective" : Book of abstracts
Belgrade : University of Belgrade, Faculty of Security Studies., 51-52.
https://hdl.handle.net/21.15107/rcub_vinar_12145

Nikolić D, Kovačević A, Stanković S. Threat Assessment for the Design of the Effective Protection System for Nuclear Installations. in International conference "National Critical Infrastructure Protection - Regional Perspective" : Book of abstracts. 2013;:51-52.
https://hdl.handle.net/21.15107/rcub_vinar_12145 .

Nikolić, Dragana, Kovačević, Ana, Stanković, Srboljub, "Threat Assessment for the Design of the Effective Protection System for Nuclear Installations" in International conference "National Critical Infrastructure Protection - Regional Perspective" : Book of abstracts (2013):51-52,
https://hdl.handle.net/21.15107/rcub_vinar_12145 .

TY  - JOUR
AU  - Nikolić, Dragana
AU  - Katsiki, Niki
AU  - Montalto, Giuseppe
AU  - Isenović, Esma R.
AU  - Mikhailidis, Dimitri P.
AU  - Rizzo, Manfredi
PY  - 2013
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/5380
AB  - Small, dense low density lipoprotein (sdLDL) represents an emerging cardiovascular risk factor, since these particles can be associated with cardiovascular disease (CVD) independently of established risk factors, including plasma lipids. Obese subjects frequently have atherogenic dyslipidaemia, including elevated sdLDL levels, in addition to elevated triglycerides (TG), very low density lipoprotein (VLDL) and apolipoprotein-B, as well as decreased high density lipoprotein cholesterol (HDL-C) levels. Obesity-related co-morbidities, such as metabolic syndrome (MetS) are also characterized by dyslipidaemia. Therefore, agents that favourably modulate LDL subclasses may be of clinical value in these subjects. Statins are the lipid-lowering drug of choice. Also, anti-obesity and lipid lowering drugs other than statins could be useful in these patients. However, the effects of anti-obesity drugs on CVD risk factors remain unclear. We review the clinical significance of sdLDL in being overweight and obesity, as well as the efficacy of anti-obesity drugs on LDL subfractions in these individuals; a short comment on HDL subclasses is also included. Our literature search was based on PubMed and Scopus listings. Further research is required to fully explore both the significance of sdLDL and the efficacy of anti-obesity drugs on LDL subfractions in being overweight, obesity and MetS. Improving the lipoprotein profile in these patients may represent an efficient approach for reducing cardiovascular risk.
T2  - Nutrients
T1  - Lipoprotein Subfractions in Metabolic Syndrome and Obesity: Clinical Significance and Therapeutic Approaches
VL  - 5
IS  - 3
SP  - 928
EP  - 948
DO  - 10.3390/nu5030928
ER  - 

@article{
author = "Nikolić, Dragana and Katsiki, Niki and Montalto, Giuseppe and Isenović, Esma R. and Mikhailidis, Dimitri P. and Rizzo, Manfredi",
year = "2013",
abstract = "Small, dense low density lipoprotein (sdLDL) represents an emerging cardiovascular risk factor, since these particles can be associated with cardiovascular disease (CVD) independently of established risk factors, including plasma lipids. Obese subjects frequently have atherogenic dyslipidaemia, including elevated sdLDL levels, in addition to elevated triglycerides (TG), very low density lipoprotein (VLDL) and apolipoprotein-B, as well as decreased high density lipoprotein cholesterol (HDL-C) levels. Obesity-related co-morbidities, such as metabolic syndrome (MetS) are also characterized by dyslipidaemia. Therefore, agents that favourably modulate LDL subclasses may be of clinical value in these subjects. Statins are the lipid-lowering drug of choice. Also, anti-obesity and lipid lowering drugs other than statins could be useful in these patients. However, the effects of anti-obesity drugs on CVD risk factors remain unclear. We review the clinical significance of sdLDL in being overweight and obesity, as well as the efficacy of anti-obesity drugs on LDL subfractions in these individuals; a short comment on HDL subclasses is also included. Our literature search was based on PubMed and Scopus listings. Further research is required to fully explore both the significance of sdLDL and the efficacy of anti-obesity drugs on LDL subfractions in being overweight, obesity and MetS. Improving the lipoprotein profile in these patients may represent an efficient approach for reducing cardiovascular risk.",
journal = "Nutrients",
title = "Lipoprotein Subfractions in Metabolic Syndrome and Obesity: Clinical Significance and Therapeutic Approaches",
volume = "5",
number = "3",
pages = "928-948",
doi = "10.3390/nu5030928"
}

Nikolić, D., Katsiki, N., Montalto, G., Isenović, E. R., Mikhailidis, D. P.,& Rizzo, M.. (2013). Lipoprotein Subfractions in Metabolic Syndrome and Obesity: Clinical Significance and Therapeutic Approaches. in Nutrients, 5(3), 928-948.
https://doi.org/10.3390/nu5030928

Nikolić D, Katsiki N, Montalto G, Isenović ER, Mikhailidis DP, Rizzo M. Lipoprotein Subfractions in Metabolic Syndrome and Obesity: Clinical Significance and Therapeutic Approaches. in Nutrients. 2013;5(3):928-948.
doi:10.3390/nu5030928 .

Nikolić, Dragana, Katsiki, Niki, Montalto, Giuseppe, Isenović, Esma R., Mikhailidis, Dimitri P., Rizzo, Manfredi, "Lipoprotein Subfractions in Metabolic Syndrome and Obesity: Clinical Significance and Therapeutic Approaches" in Nutrients, 5, no. 3 (2013):928-948,
https://doi.org/10.3390/nu5030928 . .

TY  - JOUR
AU  - Nikolić, Dragana
AU  - Djordjevic, P. B.
AU  - Lackovic, V. B.
AU  - Stojiljković, Vesna
AU  - Stanojević, Boban
PY  - 2013
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/5409
AB  - The experiment compared the physiological function (insulin secretory capacity) and membrane integrity of human adult pancreatic islets incubated in culture at 37 degrees C and 24 degrees C. Pancreatic tissue was digested with Collagenase XI, using a non-automated method. Cultures were incubated at 37 degrees C and 24 degrees C. Secretory capacity of the islets is determined by measuring of the stimulation index (SI) on the 3rd and 7th day of cultivation. Membrane integrity of the islets was determined by dithizone staining. Both groups of examined cultures show a slight increase in SI during the incubation. However islets incubated at 24 degrees C show higher SI values than those incubated at 37 degrees C on the 1st, 3rd and 7th day of incubation. And on the first day of incubation, this difference was statistically significant (p LT 0.05). Islets incubated at 37 degrees C showed preservation of membrane integrity, the islets are regular spherical shape, while those incubated at 24 degrees C lose such an organization. During the seven-day cultivation, islets incubated at a standard temperature of 37 degrees C show less preserve physiological functions in relation to cultures incubated at 24 degrees C, but islets incubated at 37 degrees C show more regular morphological forms.
T2  - Journal of Biological Regulators and Homeostatic Agents
T1  - Effect of Low Temperature Cultivation on Insulin Secretory of Human Pancreatic Islets
VL  - 27
IS  - 1
SP  - 35
EP  - 44
UR  - https://hdl.handle.net/21.15107/rcub_vinar_5409
ER  - 

@article{
author = "Nikolić, Dragana and Djordjevic, P. B. and Lackovic, V. B. and Stojiljković, Vesna and Stanojević, Boban",
year = "2013",
abstract = "The experiment compared the physiological function (insulin secretory capacity) and membrane integrity of human adult pancreatic islets incubated in culture at 37 degrees C and 24 degrees C. Pancreatic tissue was digested with Collagenase XI, using a non-automated method. Cultures were incubated at 37 degrees C and 24 degrees C. Secretory capacity of the islets is determined by measuring of the stimulation index (SI) on the 3rd and 7th day of cultivation. Membrane integrity of the islets was determined by dithizone staining. Both groups of examined cultures show a slight increase in SI during the incubation. However islets incubated at 24 degrees C show higher SI values than those incubated at 37 degrees C on the 1st, 3rd and 7th day of incubation. And on the first day of incubation, this difference was statistically significant (p LT 0.05). Islets incubated at 37 degrees C showed preservation of membrane integrity, the islets are regular spherical shape, while those incubated at 24 degrees C lose such an organization. During the seven-day cultivation, islets incubated at a standard temperature of 37 degrees C show less preserve physiological functions in relation to cultures incubated at 24 degrees C, but islets incubated at 37 degrees C show more regular morphological forms.",
journal = "Journal of Biological Regulators and Homeostatic Agents",
title = "Effect of Low Temperature Cultivation on Insulin Secretory of Human Pancreatic Islets",
volume = "27",
number = "1",
pages = "35-44",
url = "https://hdl.handle.net/21.15107/rcub_vinar_5409"
}

Nikolić, D., Djordjevic, P. B., Lackovic, V. B., Stojiljković, V.,& Stanojević, B.. (2013). Effect of Low Temperature Cultivation on Insulin Secretory of Human Pancreatic Islets. in Journal of Biological Regulators and Homeostatic Agents, 27(1), 35-44.
https://hdl.handle.net/21.15107/rcub_vinar_5409

Nikolić D, Djordjevic PB, Lackovic VB, Stojiljković V, Stanojević B. Effect of Low Temperature Cultivation on Insulin Secretory of Human Pancreatic Islets. in Journal of Biological Regulators and Homeostatic Agents. 2013;27(1):35-44.
https://hdl.handle.net/21.15107/rcub_vinar_5409 .

Nikolić, Dragana, Djordjevic, P. B., Lackovic, V. B., Stojiljković, Vesna, Stanojević, Boban, "Effect of Low Temperature Cultivation on Insulin Secretory of Human Pancreatic Islets" in Journal of Biological Regulators and Homeostatic Agents, 27, no. 1 (2013):35-44,
https://hdl.handle.net/21.15107/rcub_vinar_5409 .

TY  - JOUR
AU  - Matović, Branko
AU  - Nikolić, Dragana
AU  - Labus, N.
AU  - Ilić, Svetlana M.
AU  - Maksimović, Vesna
AU  - Luković, Jelena M.
AU  - Bučevac, Dušan
PY  - 2013
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/5722
AB  - A new technology for radionuclide trapping which is based on bio-templating approach was proposed in this paper. Porous oxide ceramics was prepared by wet impregnation of biological template with water solution of cerium and strontium nitrates. The template was derived from linden wood (tilia amurensis). Repeated pressure impregnation, heat treatments and final calcination at 1000 degrees C in air resulted in the template burnout and consolidation of the oxide layers. The obtained products had structure which corresponded to the negative replication of biological templates. X-ray diffraction, scanning electron microscopy, Raman spectroscopy and porosimetry were employed to characterize the composition and structure of biomorphic ceramics. It was found that the wood impregnated with water solution of cerium and strontium nitrates was converted into oxide ceramics (Ce0.9Sr0.1O2-delta), while preserving the microstructural features of the biological preform. (C) 2013 Elsevier Ltd and Techna Group S.r.l. All rights reserved.
T2  - Ceramics International
T1  - Preparation and properties of porous, biomorphic, ceria ceramics for immobilization of Sr isotopes
VL  - 39
IS  - 8
SP  - 9645
EP  - 9649
DO  - 10.1016/j.ceramint.2013.05.086
ER  - 

@article{
author = "Matović, Branko and Nikolić, Dragana and Labus, N. and Ilić, Svetlana M. and Maksimović, Vesna and Luković, Jelena M. and Bučevac, Dušan",
year = "2013",
abstract = "A new technology for radionuclide trapping which is based on bio-templating approach was proposed in this paper. Porous oxide ceramics was prepared by wet impregnation of biological template with water solution of cerium and strontium nitrates. The template was derived from linden wood (tilia amurensis). Repeated pressure impregnation, heat treatments and final calcination at 1000 degrees C in air resulted in the template burnout and consolidation of the oxide layers. The obtained products had structure which corresponded to the negative replication of biological templates. X-ray diffraction, scanning electron microscopy, Raman spectroscopy and porosimetry were employed to characterize the composition and structure of biomorphic ceramics. It was found that the wood impregnated with water solution of cerium and strontium nitrates was converted into oxide ceramics (Ce0.9Sr0.1O2-delta), while preserving the microstructural features of the biological preform. (C) 2013 Elsevier Ltd and Techna Group S.r.l. All rights reserved.",
journal = "Ceramics International",
title = "Preparation and properties of porous, biomorphic, ceria ceramics for immobilization of Sr isotopes",
volume = "39",
number = "8",
pages = "9645-9649",
doi = "10.1016/j.ceramint.2013.05.086"
}

Matović, B., Nikolić, D., Labus, N., Ilić, S. M., Maksimović, V., Luković, J. M.,& Bučevac, D.. (2013). Preparation and properties of porous, biomorphic, ceria ceramics for immobilization of Sr isotopes. in Ceramics International, 39(8), 9645-9649.
https://doi.org/10.1016/j.ceramint.2013.05.086

Matović B, Nikolić D, Labus N, Ilić SM, Maksimović V, Luković JM, Bučevac D. Preparation and properties of porous, biomorphic, ceria ceramics for immobilization of Sr isotopes. in Ceramics International. 2013;39(8):9645-9649.
doi:10.1016/j.ceramint.2013.05.086 .

Matović, Branko, Nikolić, Dragana, Labus, N., Ilić, Svetlana M., Maksimović, Vesna, Luković, Jelena M., Bučevac, Dušan, "Preparation and properties of porous, biomorphic, ceria ceramics for immobilization of Sr isotopes" in Ceramics International, 39, no. 8 (2013):9645-9649,
https://doi.org/10.1016/j.ceramint.2013.05.086 . .

TY  - JOUR
AU  - Stanković, Srboljub
AU  - Iricanin, Bratislav D.
AU  - Nikolić, Dragana
AU  - Janković, Ksenija S.
AU  - Radenković, Mirjana
AU  - Stankovic, Koviljka D. J.
AU  - Osmokrović, Predrag V.
PY  - 2012
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/4928
AB  - Based on the principles derived from Campbells theorem, this paper carries out an analysis of the possibilities of Campbells mean square value signal processing system. The mean square value mode is especially suitable for measurements performed in a mixed radiation field, because the quantities of electrical charge involved in the interactions of the two types of radiation are substantially different. The measuring detector element may be an adequate ionization chamber and/or semiconductor components for mixed n-gamma fields. An examination of the discrimination of gamma in relation to the neutron component in the signal of the detector output was carried out, calculated according to the theoretical model of radiation interaction with the detector. The advantage of the mean square value method was confirmed and it was concluded that the order of n-gamma discrimination in mean square value signal processing is greater than the one rendered by the classical measuring method.
T2  - Nuclear technology and radiation protection
T1  - Msv Signal Processing System for Neutron-Gamma Discrimination in a Mixed Field
VL  - 27
IS  - 2
SP  - 165
EP  - 170
DO  - 10.2298/NTRP1202165S
ER  - 

@article{
author = "Stanković, Srboljub and Iricanin, Bratislav D. and Nikolić, Dragana and Janković, Ksenija S. and Radenković, Mirjana and Stankovic, Koviljka D. J. and Osmokrović, Predrag V.",
year = "2012",
abstract = "Based on the principles derived from Campbells theorem, this paper carries out an analysis of the possibilities of Campbells mean square value signal processing system. The mean square value mode is especially suitable for measurements performed in a mixed radiation field, because the quantities of electrical charge involved in the interactions of the two types of radiation are substantially different. The measuring detector element may be an adequate ionization chamber and/or semiconductor components for mixed n-gamma fields. An examination of the discrimination of gamma in relation to the neutron component in the signal of the detector output was carried out, calculated according to the theoretical model of radiation interaction with the detector. The advantage of the mean square value method was confirmed and it was concluded that the order of n-gamma discrimination in mean square value signal processing is greater than the one rendered by the classical measuring method.",
journal = "Nuclear technology and radiation protection",
title = "Msv Signal Processing System for Neutron-Gamma Discrimination in a Mixed Field",
volume = "27",
number = "2",
pages = "165-170",
doi = "10.2298/NTRP1202165S"
}

Stanković, S., Iricanin, B. D., Nikolić, D., Janković, K. S., Radenković, M., Stankovic, K. D. J.,& Osmokrović, P. V.. (2012). Msv Signal Processing System for Neutron-Gamma Discrimination in a Mixed Field. in Nuclear technology and radiation protection, 27(2), 165-170.
https://doi.org/10.2298/NTRP1202165S

Stanković S, Iricanin BD, Nikolić D, Janković KS, Radenković M, Stankovic KDJ, Osmokrović PV. Msv Signal Processing System for Neutron-Gamma Discrimination in a Mixed Field. in Nuclear technology and radiation protection. 2012;27(2):165-170.
doi:10.2298/NTRP1202165S .

Stanković, Srboljub, Iricanin, Bratislav D., Nikolić, Dragana, Janković, Ksenija S., Radenković, Mirjana, Stankovic, Koviljka D. J., Osmokrović, Predrag V., "Msv Signal Processing System for Neutron-Gamma Discrimination in a Mixed Field" in Nuclear technology and radiation protection, 27, no. 2 (2012):165-170,
https://doi.org/10.2298/NTRP1202165S . .

TY  - JOUR
AU  - Dobutović, Branislava
AU  - Sudar, Emina
AU  - Soskić, Sanja S.
AU  - Obradović, Milan M.
AU  - Nikolić, Dragana
AU  - Gluvić, Zoran
AU  - Stokić, Edita
AU  - Radak, Đorđe J.
AU  - Isenović, Esma R.
PY  - 2012
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10323
AB  - Gojaznost se danas smatra bolešću savremenog društva i njena zastupljenost u svetu ima karakter epidemije. Istraživanja usmerena na razumevanje biologije adipocitne ćelije i adipoznog tkiva, značajno doprinose rasvetljavanju mnogih aspekata različitih metaboličkih poremećaja koji prate pojavu gojaznosti tj. prekomerenog prisustva adipoznog tkiva. Gojaznost je posledica dugotrajnog pozitivnog energetskog balansa, neprimerenog stilu života savremenog čoveka. Danas je utemeljena činjenica da je adipozno tkivo endokrini organ u kojem se sintetiše i eksprimira više od 60 različitih faktora - adipokina, sa snažnim uticajem na veliki broj metaboličkih procesa u organizmu. Adipokini mogu imati pro-inflamatorno ili anti-inflamatorno dejstvo. Mnogobrojna istraživanja jasno ukazuju na uzročnu vezu gojaznosti i hronične inflamacije slabog inteziteta, koja vodi razvoju poremećaja vezanih za prisustvo gojaznosti, naročito metaboličkih poremećaja koji znatno umanjuju kvalitet života. Svojom endokrinom funkcijom, adipocitne ćelije reflektuju metabolički status i prenose informaciju na druge organe, tkiva kao i centralni nervni sistem.
AB  - Obesity is a disease of the modern society and considering the number of obese people it has character of the worldwide epidemic. Understanding the biology of adipocytes and the events occurring in adipose tissue contributes to clarification of many aspects of the various metabolic disorders associated with obesity and excessive presence of adipose tissue. Overweight in individuals is the result of a long-term positive energy balance inappropriate to life style of the modern man. Today, it is well accepted that adipose tissue is an endocrine organ in which more than 60 of adipokines are synthesized and are expressed with strong influence on a great number of metabolic processes in organism. Adipokines have pro-inflammatory or anti-inflammatory effects. Increasing evidence indicates that obesity is causally linked to a chronic low-grade inflammatory state, and contributes to the development of obesity-linked disorders, in particular to metabolic dysfunction which significantly reduces the quality of life. Adipocytes, with their endocrine function, reflect metabolic status and transport information into organs, tissues and central nervous system, too.
T2  - Medicinska istraživanja
T1  - Patofiziologija gojaznosti
T1  - Pathophysiology of obesity
VL  - 46
IS  - 1
SP  - 43
EP  - 54
UR  - https://hdl.handle.net/21.15107/rcub_vinar_10323
ER  - 

@article{
author = "Dobutović, Branislava and Sudar, Emina and Soskić, Sanja S. and Obradović, Milan M. and Nikolić, Dragana and Gluvić, Zoran and Stokić, Edita and Radak, Đorđe J. and Isenović, Esma R.",
year = "2012",
abstract = "Gojaznost se danas smatra bolešću savremenog društva i njena zastupljenost u svetu ima karakter epidemije. Istraživanja usmerena na razumevanje biologije adipocitne ćelije i adipoznog tkiva, značajno doprinose rasvetljavanju mnogih aspekata različitih metaboličkih poremećaja koji prate pojavu gojaznosti tj. prekomerenog prisustva adipoznog tkiva. Gojaznost je posledica dugotrajnog pozitivnog energetskog balansa, neprimerenog stilu života savremenog čoveka. Danas je utemeljena činjenica da je adipozno tkivo endokrini organ u kojem se sintetiše i eksprimira više od 60 različitih faktora - adipokina, sa snažnim uticajem na veliki broj metaboličkih procesa u organizmu. Adipokini mogu imati pro-inflamatorno ili anti-inflamatorno dejstvo. Mnogobrojna istraživanja jasno ukazuju na uzročnu vezu gojaznosti i hronične inflamacije slabog inteziteta, koja vodi razvoju poremećaja vezanih za prisustvo gojaznosti, naročito metaboličkih poremećaja koji znatno umanjuju kvalitet života. Svojom endokrinom funkcijom, adipocitne ćelije reflektuju metabolički status i prenose informaciju na druge organe, tkiva kao i centralni nervni sistem., Obesity is a disease of the modern society and considering the number of obese people it has character of the worldwide epidemic. Understanding the biology of adipocytes and the events occurring in adipose tissue contributes to clarification of many aspects of the various metabolic disorders associated with obesity and excessive presence of adipose tissue. Overweight in individuals is the result of a long-term positive energy balance inappropriate to life style of the modern man. Today, it is well accepted that adipose tissue is an endocrine organ in which more than 60 of adipokines are synthesized and are expressed with strong influence on a great number of metabolic processes in organism. Adipokines have pro-inflammatory or anti-inflammatory effects. Increasing evidence indicates that obesity is causally linked to a chronic low-grade inflammatory state, and contributes to the development of obesity-linked disorders, in particular to metabolic dysfunction which significantly reduces the quality of life. Adipocytes, with their endocrine function, reflect metabolic status and transport information into organs, tissues and central nervous system, too.",
journal = "Medicinska istraživanja",
title = "Patofiziologija gojaznosti, Pathophysiology of obesity",
volume = "46",
number = "1",
pages = "43-54",
url = "https://hdl.handle.net/21.15107/rcub_vinar_10323"
}

Dobutović, B., Sudar, E., Soskić, S. S., Obradović, M. M., Nikolić, D., Gluvić, Z., Stokić, E., Radak, Đ. J.,& Isenović, E. R.. (2012). Patofiziologija gojaznosti. in Medicinska istraživanja, 46(1), 43-54.
https://hdl.handle.net/21.15107/rcub_vinar_10323

Dobutović B, Sudar E, Soskić SS, Obradović MM, Nikolić D, Gluvić Z, Stokić E, Radak ĐJ, Isenović ER. Patofiziologija gojaznosti. in Medicinska istraživanja. 2012;46(1):43-54.
https://hdl.handle.net/21.15107/rcub_vinar_10323 .

Dobutović, Branislava, Sudar, Emina, Soskić, Sanja S., Obradović, Milan M., Nikolić, Dragana, Gluvić, Zoran, Stokić, Edita, Radak, Đorđe J., Isenović, Esma R., "Patofiziologija gojaznosti" in Medicinska istraživanja, 46, no. 1 (2012):43-54,
https://hdl.handle.net/21.15107/rcub_vinar_10323 .

TY  - CONF
AU  - Stanković, Srboljub
AU  - Ilić, Radovan D.
AU  - Nikolić, Dragana
AU  - Čekerevac, D.
AU  - Lončar, Boris
AU  - Živanović, Miloš
PY  - 2012
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/12149
AB  - In recent years, an increasing number of research works have been addressed to the study of the characteristics and applications of MOSFET detectors in the field of nuclear industry, medical applications and space research. At a time when the stormy development of technology, a new type of solid state dosimeter, the MOSFET detector, has been introduced into the radiotherapy, primarily for in vivo patient dosimetry in electron-beam irradiation. One of the major goals of our work was the presentation of the shielding energy dependence factor which assesses the impact of the lid with different shielding materials to MOSFET response for different energies of electron-beam irradiation into range 4 MeV – 20 MeV. In doing so, the established Monte Carlo numerical method for analysis influence of the packaging to energy dependence, carried out prior to any experimental testing. The bare MOSFET is encapsulated in epoxy glue which mechanically protects the chip. To trace the influence of the lid is the one intended by the physical protection, on the other hand, it can also be used for the protection against radiation, is introduced that defines the shielding energy dependence factor (SDEF) for different electron energies and for different constructional materials of lid. Factor SDEF is defined as the ratio of values of the absorbed dose, which in fact means that it is equal to the energy deposited when the MOSFET is shielded with protection, and the MOSFET without a lid. When we know the energy dependence factor for SDEF MOSFET with and without armor can be carried out and the analysis of whether and to what extent the energy required compensating the electronic components. In order to use the Monte Carlo numerical methods in this paper, the appropriate geometry form of the MOSFET dosimeter was defined using the adequate software. The electron transport Monte Carlo code FOTELP-2K10 has been adopted to analyze the influence of the MOSFET package on its energy response. FOTELP-2K10 code, uses RFG and PENGEOM6 software modules for dosimeter geometry description. Observations indicate that the MOSFET response is dependent on electron energy as well as varying with the package configuration. The packaging effect was investigated by comparising the total energy deposited in zones of the MOSFET structure. In this work presented, the ratio between values of total energy deposited in the sensitive volume (thick SiO2 layer) for cases of MOSFET structure with and without a package lid. For this purpose is defined the shielding energy dependence factor (SDEF), and is given its value for kovar and Ti-24Al-11Nb and Ti-13Nb-13Zr alloys as lid materials. Further, we have done the identification of the dependence of the total energy deposited with varying of photon energy, for all zones of interest with specially selected type of the MOSFET dosimeter.
PB  - University of Niš : Faculty of Electronic Engineering
C3  - RAD 2012 : 1st International Conference on Radiation in Various Fields of Research : Book of abstracts
T1  - Numerical analysis of the shielding energy dependence factor of the MOSFET dosimeter in electron-beams irradiation
SP  - 34
EP  - 34
UR  - https://hdl.handle.net/21.15107/rcub_vinar_12149
ER  - 

@conference{
author = "Stanković, Srboljub and Ilić, Radovan D. and Nikolić, Dragana and Čekerevac, D. and Lončar, Boris and Živanović, Miloš",
year = "2012",
abstract = "In recent years, an increasing number of research works have been addressed to the study of the characteristics and applications of MOSFET detectors in the field of nuclear industry, medical applications and space research. At a time when the stormy development of technology, a new type of solid state dosimeter, the MOSFET detector, has been introduced into the radiotherapy, primarily for in vivo patient dosimetry in electron-beam irradiation. One of the major goals of our work was the presentation of the shielding energy dependence factor which assesses the impact of the lid with different shielding materials to MOSFET response for different energies of electron-beam irradiation into range 4 MeV – 20 MeV. In doing so, the established Monte Carlo numerical method for analysis influence of the packaging to energy dependence, carried out prior to any experimental testing. The bare MOSFET is encapsulated in epoxy glue which mechanically protects the chip. To trace the influence of the lid is the one intended by the physical protection, on the other hand, it can also be used for the protection against radiation, is introduced that defines the shielding energy dependence factor (SDEF) for different electron energies and for different constructional materials of lid. Factor SDEF is defined as the ratio of values of the absorbed dose, which in fact means that it is equal to the energy deposited when the MOSFET is shielded with protection, and the MOSFET without a lid. When we know the energy dependence factor for SDEF MOSFET with and without armor can be carried out and the analysis of whether and to what extent the energy required compensating the electronic components. In order to use the Monte Carlo numerical methods in this paper, the appropriate geometry form of the MOSFET dosimeter was defined using the adequate software. The electron transport Monte Carlo code FOTELP-2K10 has been adopted to analyze the influence of the MOSFET package on its energy response. FOTELP-2K10 code, uses RFG and PENGEOM6 software modules for dosimeter geometry description. Observations indicate that the MOSFET response is dependent on electron energy as well as varying with the package configuration. The packaging effect was investigated by comparising the total energy deposited in zones of the MOSFET structure. In this work presented, the ratio between values of total energy deposited in the sensitive volume (thick SiO2 layer) for cases of MOSFET structure with and without a package lid. For this purpose is defined the shielding energy dependence factor (SDEF), and is given its value for kovar and Ti-24Al-11Nb and Ti-13Nb-13Zr alloys as lid materials. Further, we have done the identification of the dependence of the total energy deposited with varying of photon energy, for all zones of interest with specially selected type of the MOSFET dosimeter.",
publisher = "University of Niš : Faculty of Electronic Engineering",
journal = "RAD 2012 : 1st International Conference on Radiation in Various Fields of Research : Book of abstracts",
title = "Numerical analysis of the shielding energy dependence factor of the MOSFET dosimeter in electron-beams irradiation",
pages = "34-34",
url = "https://hdl.handle.net/21.15107/rcub_vinar_12149"
}

Stanković, S., Ilić, R. D., Nikolić, D., Čekerevac, D., Lončar, B.,& Živanović, M.. (2012). Numerical analysis of the shielding energy dependence factor of the MOSFET dosimeter in electron-beams irradiation. in RAD 2012 : 1st International Conference on Radiation in Various Fields of Research : Book of abstracts
University of Niš : Faculty of Electronic Engineering., 34-34.
https://hdl.handle.net/21.15107/rcub_vinar_12149

Stanković S, Ilić RD, Nikolić D, Čekerevac D, Lončar B, Živanović M. Numerical analysis of the shielding energy dependence factor of the MOSFET dosimeter in electron-beams irradiation. in RAD 2012 : 1st International Conference on Radiation in Various Fields of Research : Book of abstracts. 2012;:34-34.
https://hdl.handle.net/21.15107/rcub_vinar_12149 .

Stanković, Srboljub, Ilić, Radovan D., Nikolić, Dragana, Čekerevac, D., Lončar, Boris, Živanović, Miloš, "Numerical analysis of the shielding energy dependence factor of the MOSFET dosimeter in electron-beams irradiation" in RAD 2012 : 1st International Conference on Radiation in Various Fields of Research : Book of abstracts (2012):34-34,
https://hdl.handle.net/21.15107/rcub_vinar_12149 .

TY  - CHAP
AU  - Nikolić, Dragana
AU  - Kovačević, Ana
AU  - Stanković, Srboljub
PY  - 2012
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/12143
PB  - Ljubljana : Institute for Corporative Security Studies ; Monterey : Center for Civil-Military Relations
T2  - Managing the consequences of terrorist acts : efficiency and coordination challenges
T1  - Comprehensive approach to tactical response in the case of terrorist acts involving WMD
SP  - 99
EP  - 117
UR  - https://hdl.handle.net/21.15107/rcub_vinar_12143
ER  - 

@inbook{
author = "Nikolić, Dragana and Kovačević, Ana and Stanković, Srboljub",
year = "2012",
publisher = "Ljubljana : Institute for Corporative Security Studies ; Monterey : Center for Civil-Military Relations",
journal = "Managing the consequences of terrorist acts : efficiency and coordination challenges",
booktitle = "Comprehensive approach to tactical response in the case of terrorist acts involving WMD",
pages = "99-117",
url = "https://hdl.handle.net/21.15107/rcub_vinar_12143"
}

Nikolić, D., Kovačević, A.,& Stanković, S.. (2012). Comprehensive approach to tactical response in the case of terrorist acts involving WMD. in Managing the consequences of terrorist acts : efficiency and coordination challenges
Ljubljana : Institute for Corporative Security Studies ; Monterey : Center for Civil-Military Relations., 99-117.
https://hdl.handle.net/21.15107/rcub_vinar_12143

Nikolić D, Kovačević A, Stanković S. Comprehensive approach to tactical response in the case of terrorist acts involving WMD. in Managing the consequences of terrorist acts : efficiency and coordination challenges. 2012;:99-117.
https://hdl.handle.net/21.15107/rcub_vinar_12143 .

Nikolić, Dragana, Kovačević, Ana, Stanković, Srboljub, "Comprehensive approach to tactical response in the case of terrorist acts involving WMD" in Managing the consequences of terrorist acts : efficiency and coordination challenges (2012):99-117,
https://hdl.handle.net/21.15107/rcub_vinar_12143 .

TY  - JOUR
AU  - Nikolić, Dragana
AU  - Djordjevic, P. B.
AU  - Radak, Đorđe J.
AU  - Lackovic, Vesna B.
AU  - Bajčetić, Miloš I.
AU  - Milić, Gordana A.
AU  - Gostiljac, D.
AU  - Ilic, M.
AU  - Raketic, Nevenka
AU  - Stojiljković, Vesna
AU  - Grubor, Nikica M.
AU  - Jovanovic, M. D.
AU  - Latincic, S. M.
PY  - 2011
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/4653
AB  - In this study we compared the effects of duration of cold ischemia (longer and shorter ischemia) on the yield, viability and preservation of the physiological function and insulin secretion of adult human pancreatic islets in short-term (seven days) culture. Based on the tested parameters, we established that there are no major differences between these two test groups and that the storage and transport of pancreatic tissue in physiological solution at 4 degrees C gives quite satisfactory results.
T2  - Archives of Biological Sciences
T1  - Extended Time of Cold Ischemia and Its Influence on the Physiological Function of Human Adult Pancreatic Islets
VL  - 63
IS  - 4
SP  - 1007
EP  - 1013
DO  - 10.2298/ABS1104007N
ER  - 

@article{
author = "Nikolić, Dragana and Djordjevic, P. B. and Radak, Đorđe J. and Lackovic, Vesna B. and Bajčetić, Miloš I. and Milić, Gordana A. and Gostiljac, D. and Ilic, M. and Raketic, Nevenka and Stojiljković, Vesna and Grubor, Nikica M. and Jovanovic, M. D. and Latincic, S. M.",
year = "2011",
abstract = "In this study we compared the effects of duration of cold ischemia (longer and shorter ischemia) on the yield, viability and preservation of the physiological function and insulin secretion of adult human pancreatic islets in short-term (seven days) culture. Based on the tested parameters, we established that there are no major differences between these two test groups and that the storage and transport of pancreatic tissue in physiological solution at 4 degrees C gives quite satisfactory results.",
journal = "Archives of Biological Sciences",
title = "Extended Time of Cold Ischemia and Its Influence on the Physiological Function of Human Adult Pancreatic Islets",
volume = "63",
number = "4",
pages = "1007-1013",
doi = "10.2298/ABS1104007N"
}

Nikolić, D., Djordjevic, P. B., Radak, Đ. J., Lackovic, V. B., Bajčetić, M. I., Milić, G. A., Gostiljac, D., Ilic, M., Raketic, N., Stojiljković, V., Grubor, N. M., Jovanovic, M. D.,& Latincic, S. M.. (2011). Extended Time of Cold Ischemia and Its Influence on the Physiological Function of Human Adult Pancreatic Islets. in Archives of Biological Sciences, 63(4), 1007-1013.
https://doi.org/10.2298/ABS1104007N

Nikolić D, Djordjevic PB, Radak ĐJ, Lackovic VB, Bajčetić MI, Milić GA, Gostiljac D, Ilic M, Raketic N, Stojiljković V, Grubor NM, Jovanovic MD, Latincic SM. Extended Time of Cold Ischemia and Its Influence on the Physiological Function of Human Adult Pancreatic Islets. in Archives of Biological Sciences. 2011;63(4):1007-1013.
doi:10.2298/ABS1104007N .

Nikolić, Dragana, Djordjevic, P. B., Radak, Đorđe J., Lackovic, Vesna B., Bajčetić, Miloš I., Milić, Gordana A., Gostiljac, D., Ilic, M., Raketic, Nevenka, Stojiljković, Vesna, Grubor, Nikica M., Jovanovic, M. D., Latincic, S. M., "Extended Time of Cold Ischemia and Its Influence on the Physiological Function of Human Adult Pancreatic Islets" in Archives of Biological Sciences, 63, no. 4 (2011):1007-1013,
https://doi.org/10.2298/ABS1104007N . .

TY  - JOUR
AU  - Obradović, Milan M.
AU  - Nikolić, Dragana
AU  - Dobutović, Branislava
AU  - Sudar, Emina
AU  - Soskić, Sanja S.
AU  - Tanasković, Slobodan
AU  - Boljević, Miljana
AU  - Mušicki, Biljana
AU  - Radak, Đorđe J.
AU  - Isenović, Esma R.
PY  - 2011
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10325
AB  - Ateroskleroza se manifestuje kao bolest koronarnih, perifernih i cerebrovaskularnih arterija. Aterosklerotične promene dovode do sužavanja prečnika arterija što dovodi do ishemije u mnogobrojnim organima, čime je poremećeno normalno funkcionisanje kako organa tako i organizma u celini. Centralnu ulogu u patogenezi ateroskleroze zauzima aterogena dislipidemija. Razvoj ateroskleroze počinje malim oštećenjima endotela izazvanim različitim činiocima, koji mogu uticati na povećanje ekspresije adhezivnih molekula. Disfunkcionalni endotel je mesto gde dolazi do infiltracije i akumulacije lipoproteina male gustine (LDL) u vaskularnom zidu. LDL tada podleže oksidativnoj modifikaciji, a kao krajnji produkt nastaje oksidovani LDL (oxLDL). Mnogobrojna eksperimentalna istraživanja ukazuju da su male guste LDL-čestice mnogo aterogenije u poređenju sa većim i lakšim LDL česticama. LDL podleže različitom stepenu oksidacije. Minimalno oksidovani LDL (LDL( - )) pokazuje svoj aterogeni potencijal time što stimuliše vaskularne endotelne ćelije na lučenje velikog broja proinflamatornih molekula kao što su adhezivni molekuli, hemotaktni proteini i faktori rasta. Za razliku od LDL(-), potpuno oksidovani LDL nema sposobnost preuzimanja putem LDL receptora već ga prepoznaju recptori 'hvatači', što dovodi do formiranja makrofag penastih ćelija a u nastavku i stvaranja ateroma. Prisustvo oxLDL u cirkulaciji kod ljudi predstavlja jedan od glavnih faktora rizika od kardiovaskularnih bolesti i ateroskleroze. Buduće studije imaju zadatak da izuče šta se dešava sa oxLDL- om in vivo, kao i da li je i u kojoj meri oksidacija LDL koja igra ključnu ulogu u nastanku penastih ćelija, značajna u kasnijim fazama stvaranja plaka.U okviru ovog preglednog člana, izloženi su najnoviji podaci iz litearture o uticaju oxLDL-a u patogenezi arteroskleroze.
AB  - Atherosclerosis is manifested as a disease of coronary, cerebrovascular and peripheral arteries. Atherosclerotic changes lead to narrowing of the diameter of the arteries leading to ischemia in various organs, which disturbes the normal functioning of both organs and organism as a whole. Atherogenic dyslipidemia has a central role in the pathogenesis of atherosclerosis. Development of atherosclerosis begins with endothelial damage caused by variety of factors, which may cause an increase in expression of adhesion molecules. Dysfunctional endothelium is the place where infiltration and accumulation of low density lipoprotein (LDL) in the vascular wall occurs. LDL undergoes oxidative modification and the final product produced is oxidized LDL (oxLDL). Numerous experimental studies sug- gest that small dense LDL particles are particularly atherogenic compared with larger and lighter LDL particles. LDL is subject to varying degrees of oxidation. Minimally oxidized LDL (LDL(- )) exhibits its atherogenic potential by stimulating vascular endothelial cells to secrete a large number of proinflammatory molecules, such as adhesion molecules, chemotactic proteins, and growth factors. Unlike the LDL(-), fully oxidized LDL cannot bind the LDL receptors, but is recognized by scavenger receptors, which leads to the formation of macrophage foam cells and eventually atheroma. The presence of oxLDL in the circulation in humans is a major risk factor for cardiovascular disease and atherosclerosis. Future studies are warranted to elucidate the role of oxLDL in vivo, and whether and to what extent oxidation of LDL, which plays a key role in the development of foam cells, is critical for later stages in creating the plaque. In this review article, we present current knowledge of the impact of oxLDL in the pathogenesis of arteriosclerosis.
T2  - Medicinska istraživanja
T1  - Ateroskleroza i efekti oksidacije lipoproteina male gustine u patogenezi arteroskleroze
T1  - Aterosclerosis and effect of oxidation low density lipoprotein in patogenesis of aterosclerosis
VL  - 45
IS  - 4
SP  - 66
EP  - 71
UR  - https://hdl.handle.net/21.15107/rcub_vinar_10325
ER  - 

@article{
author = "Obradović, Milan M. and Nikolić, Dragana and Dobutović, Branislava and Sudar, Emina and Soskić, Sanja S. and Tanasković, Slobodan and Boljević, Miljana and Mušicki, Biljana and Radak, Đorđe J. and Isenović, Esma R.",
year = "2011",
abstract = "Ateroskleroza se manifestuje kao bolest koronarnih, perifernih i cerebrovaskularnih arterija. Aterosklerotične promene dovode do sužavanja prečnika arterija što dovodi do ishemije u mnogobrojnim organima, čime je poremećeno normalno funkcionisanje kako organa tako i organizma u celini. Centralnu ulogu u patogenezi ateroskleroze zauzima aterogena dislipidemija. Razvoj ateroskleroze počinje malim oštećenjima endotela izazvanim različitim činiocima, koji mogu uticati na povećanje ekspresije adhezivnih molekula. Disfunkcionalni endotel je mesto gde dolazi do infiltracije i akumulacije lipoproteina male gustine (LDL) u vaskularnom zidu. LDL tada podleže oksidativnoj modifikaciji, a kao krajnji produkt nastaje oksidovani LDL (oxLDL). Mnogobrojna eksperimentalna istraživanja ukazuju da su male guste LDL-čestice mnogo aterogenije u poređenju sa većim i lakšim LDL česticama. LDL podleže različitom stepenu oksidacije. Minimalno oksidovani LDL (LDL( - )) pokazuje svoj aterogeni potencijal time što stimuliše vaskularne endotelne ćelije na lučenje velikog broja proinflamatornih molekula kao što su adhezivni molekuli, hemotaktni proteini i faktori rasta. Za razliku od LDL(-), potpuno oksidovani LDL nema sposobnost preuzimanja putem LDL receptora već ga prepoznaju recptori 'hvatači', što dovodi do formiranja makrofag penastih ćelija a u nastavku i stvaranja ateroma. Prisustvo oxLDL u cirkulaciji kod ljudi predstavlja jedan od glavnih faktora rizika od kardiovaskularnih bolesti i ateroskleroze. Buduće studije imaju zadatak da izuče šta se dešava sa oxLDL- om in vivo, kao i da li je i u kojoj meri oksidacija LDL koja igra ključnu ulogu u nastanku penastih ćelija, značajna u kasnijim fazama stvaranja plaka.U okviru ovog preglednog člana, izloženi su najnoviji podaci iz litearture o uticaju oxLDL-a u patogenezi arteroskleroze., Atherosclerosis is manifested as a disease of coronary, cerebrovascular and peripheral arteries. Atherosclerotic changes lead to narrowing of the diameter of the arteries leading to ischemia in various organs, which disturbes the normal functioning of both organs and organism as a whole. Atherogenic dyslipidemia has a central role in the pathogenesis of atherosclerosis. Development of atherosclerosis begins with endothelial damage caused by variety of factors, which may cause an increase in expression of adhesion molecules. Dysfunctional endothelium is the place where infiltration and accumulation of low density lipoprotein (LDL) in the vascular wall occurs. LDL undergoes oxidative modification and the final product produced is oxidized LDL (oxLDL). Numerous experimental studies sug- gest that small dense LDL particles are particularly atherogenic compared with larger and lighter LDL particles. LDL is subject to varying degrees of oxidation. Minimally oxidized LDL (LDL(- )) exhibits its atherogenic potential by stimulating vascular endothelial cells to secrete a large number of proinflammatory molecules, such as adhesion molecules, chemotactic proteins, and growth factors. Unlike the LDL(-), fully oxidized LDL cannot bind the LDL receptors, but is recognized by scavenger receptors, which leads to the formation of macrophage foam cells and eventually atheroma. The presence of oxLDL in the circulation in humans is a major risk factor for cardiovascular disease and atherosclerosis. Future studies are warranted to elucidate the role of oxLDL in vivo, and whether and to what extent oxidation of LDL, which plays a key role in the development of foam cells, is critical for later stages in creating the plaque. In this review article, we present current knowledge of the impact of oxLDL in the pathogenesis of arteriosclerosis.",
journal = "Medicinska istraživanja",
title = "Ateroskleroza i efekti oksidacije lipoproteina male gustine u patogenezi arteroskleroze, Aterosclerosis and effect of oxidation low density lipoprotein in patogenesis of aterosclerosis",
volume = "45",
number = "4",
pages = "66-71",
url = "https://hdl.handle.net/21.15107/rcub_vinar_10325"
}

Obradović, M. M., Nikolić, D., Dobutović, B., Sudar, E., Soskić, S. S., Tanasković, S., Boljević, M., Mušicki, B., Radak, Đ. J.,& Isenović, E. R.. (2011). Ateroskleroza i efekti oksidacije lipoproteina male gustine u patogenezi arteroskleroze. in Medicinska istraživanja, 45(4), 66-71.
https://hdl.handle.net/21.15107/rcub_vinar_10325

Obradović MM, Nikolić D, Dobutović B, Sudar E, Soskić SS, Tanasković S, Boljević M, Mušicki B, Radak ĐJ, Isenović ER. Ateroskleroza i efekti oksidacije lipoproteina male gustine u patogenezi arteroskleroze. in Medicinska istraživanja. 2011;45(4):66-71.
https://hdl.handle.net/21.15107/rcub_vinar_10325 .

Obradović, Milan M., Nikolić, Dragana, Dobutović, Branislava, Sudar, Emina, Soskić, Sanja S., Tanasković, Slobodan, Boljević, Miljana, Mušicki, Biljana, Radak, Đorđe J., Isenović, Esma R., "Ateroskleroza i efekti oksidacije lipoproteina male gustine u patogenezi arteroskleroze" in Medicinska istraživanja, 45, no. 4 (2011):66-71,
https://hdl.handle.net/21.15107/rcub_vinar_10325 .

TY  - JOUR
AU  - Sudar, Emina
AU  - Stokić, Edita
AU  - Nikolić, Dragana
AU  - Dobutović, Branislava
AU  - Soskić, Sanja S.
AU  - Obradović, Milan M.
AU  - Tanasković, Slobodan
AU  - Radak, Đorđe J.
AU  - Isenović, Esma R.
PY  - 2011
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10326
AB  - Sekretagozi hormona rasta (GHS) su sintetička jedinjenja koja su potentni stimulatori oslobađanja hormona rasta (GH) i deluju preko receptora spregnutog sa guanin nukleotid-vezujućim (G) proteinom, koji se naziva GHS-receptor (GHS-R). Metodom reverzne farmakologije identifikovan je i okarakterisan endogeni ligand za GHS-R tipa 1a (GHS-R1a), koji je nazvan grelin. Grelin je peptidni hormon građen od 28 aminokiselina, u kome je aminokiselina Serin-3 (Ser3) noktanoilovana, odnosno ima modifikaciju u vidu lanca masnih kiselina koja je esencijalna za njegovu aktivnost. Grelin se najviše sintetiše u želucu, a GHS-R su eksprimirani većinom u hipotalamusu i hipofizi. Ishrana je najvažniji faktor koji utiče na regulaciju sekrecije grelina. Koncentracija grelina u cirkulaciji povećana je za vreme gladovanja, a opada nakon uzimanja hrane. Grelin stimuliše oslobađanje GH u mnogo većim količinama nego maksimalne doze GH-oslobađajućeg hormona (GHRH) što ukazuje na drugačiji mehanizam delovanja grelina na nivou hipofize. iRNK za grelin i za GHS-R1a identifikovane su i u srcu i u aorti. Proučavanja efekata grelina, pokazala su njegove povoljne efekte na kardiovaskularni sistem (CVS). S obzirom da grelin stimuliše oslobađanje GH, za koji je ranije pokazano da ima kardioprotektivne efekte, grelin može da ispoljava povoljne efekte na CVS posredovane preko GH, ali i efekte koji su nezavisni od efekata GH. Povoljni efekti grelina na CVS pružaju mogućnost da se grelin koristi u terapiji oboljenja CVS kao što su poremećaji u radu srca, hipertenzija i bolesti ishemije srca.
AB  - Small synthetic molecules called growth hormone (GH) secretagogues (GHS) stimulate the release of GH from the pituitary. They act through the GHS-receptor (GHS-R), a G protein coupled receptor. Recently, by using a method of reverse pharmacology the endogenous ligand for the GHS-R type 1a (GHS-R1a) has been discovered. Ghrelin is a 28 amino acid peptide hormone in which the third amino acid serine (Ser3) is modified by a fatty acid and this modification is essential for ghrelin's activity. Ghrelin is produced mainly in the stomach and GHS-R is mainly expressed in hypothalamus and in the pituitary. The discovery of ghrelin indicates that the release of GH from the pituitary might be regulated not only by hypothalamic GH-releasing hormone (GHRH), but also by ghrelin derived from the stomach. In addition, ghrelin stimulates appetite by acting on the hypothalamic arcuate nucleus, a region known to control food intake. The tissue distribution of ghrelin is widespread, and it is also present in cardiomyocytes. In addition, expression of mRNA encoding both ghrelin and GHSR-1a has been observed in the heart and aortas. Recent evidence indicates that ghrelin feature a variety of cardiovascular activities, including increase of myocardial contractility, vasodilatation, and protection from myocardial infarction. It has been shown that ghrelin may improve cardiac function partly through GH dependent mechanisms but also, some evidence suggests that ghrelin's cardioprotective activity is independent from GH secretion. Thus, ghrelin may be a new therapeutic agent for the treatment of some cardiovascular disturbances and diseases. Further studies are necessary to investigate the potential mechanisms for the effects of ghrelin on cardiovascular system.
T2  - Medicinska istraživanja
T1  - Opšte osobine i efekti grelina na kardiovaskularni sistem
T1  - Ghrelin structure and cardiovascular effects
VL  - 45
IS  - 4
SP  - 15
EP  - 29
UR  - https://hdl.handle.net/21.15107/rcub_vinar_10326
ER  - 

@article{
author = "Sudar, Emina and Stokić, Edita and Nikolić, Dragana and Dobutović, Branislava and Soskić, Sanja S. and Obradović, Milan M. and Tanasković, Slobodan and Radak, Đorđe J. and Isenović, Esma R.",
year = "2011",
abstract = "Sekretagozi hormona rasta (GHS) su sintetička jedinjenja koja su potentni stimulatori oslobađanja hormona rasta (GH) i deluju preko receptora spregnutog sa guanin nukleotid-vezujućim (G) proteinom, koji se naziva GHS-receptor (GHS-R). Metodom reverzne farmakologije identifikovan je i okarakterisan endogeni ligand za GHS-R tipa 1a (GHS-R1a), koji je nazvan grelin. Grelin je peptidni hormon građen od 28 aminokiselina, u kome je aminokiselina Serin-3 (Ser3) noktanoilovana, odnosno ima modifikaciju u vidu lanca masnih kiselina koja je esencijalna za njegovu aktivnost. Grelin se najviše sintetiše u želucu, a GHS-R su eksprimirani većinom u hipotalamusu i hipofizi. Ishrana je najvažniji faktor koji utiče na regulaciju sekrecije grelina. Koncentracija grelina u cirkulaciji povećana je za vreme gladovanja, a opada nakon uzimanja hrane. Grelin stimuliše oslobađanje GH u mnogo većim količinama nego maksimalne doze GH-oslobađajućeg hormona (GHRH) što ukazuje na drugačiji mehanizam delovanja grelina na nivou hipofize. iRNK za grelin i za GHS-R1a identifikovane su i u srcu i u aorti. Proučavanja efekata grelina, pokazala su njegove povoljne efekte na kardiovaskularni sistem (CVS). S obzirom da grelin stimuliše oslobađanje GH, za koji je ranije pokazano da ima kardioprotektivne efekte, grelin može da ispoljava povoljne efekte na CVS posredovane preko GH, ali i efekte koji su nezavisni od efekata GH. Povoljni efekti grelina na CVS pružaju mogućnost da se grelin koristi u terapiji oboljenja CVS kao što su poremećaji u radu srca, hipertenzija i bolesti ishemije srca., Small synthetic molecules called growth hormone (GH) secretagogues (GHS) stimulate the release of GH from the pituitary. They act through the GHS-receptor (GHS-R), a G protein coupled receptor. Recently, by using a method of reverse pharmacology the endogenous ligand for the GHS-R type 1a (GHS-R1a) has been discovered. Ghrelin is a 28 amino acid peptide hormone in which the third amino acid serine (Ser3) is modified by a fatty acid and this modification is essential for ghrelin's activity. Ghrelin is produced mainly in the stomach and GHS-R is mainly expressed in hypothalamus and in the pituitary. The discovery of ghrelin indicates that the release of GH from the pituitary might be regulated not only by hypothalamic GH-releasing hormone (GHRH), but also by ghrelin derived from the stomach. In addition, ghrelin stimulates appetite by acting on the hypothalamic arcuate nucleus, a region known to control food intake. The tissue distribution of ghrelin is widespread, and it is also present in cardiomyocytes. In addition, expression of mRNA encoding both ghrelin and GHSR-1a has been observed in the heart and aortas. Recent evidence indicates that ghrelin feature a variety of cardiovascular activities, including increase of myocardial contractility, vasodilatation, and protection from myocardial infarction. It has been shown that ghrelin may improve cardiac function partly through GH dependent mechanisms but also, some evidence suggests that ghrelin's cardioprotective activity is independent from GH secretion. Thus, ghrelin may be a new therapeutic agent for the treatment of some cardiovascular disturbances and diseases. Further studies are necessary to investigate the potential mechanisms for the effects of ghrelin on cardiovascular system.",
journal = "Medicinska istraživanja",
title = "Opšte osobine i efekti grelina na kardiovaskularni sistem, Ghrelin structure and cardiovascular effects",
volume = "45",
number = "4",
pages = "15-29",
url = "https://hdl.handle.net/21.15107/rcub_vinar_10326"
}

Sudar, E., Stokić, E., Nikolić, D., Dobutović, B., Soskić, S. S., Obradović, M. M., Tanasković, S., Radak, Đ. J.,& Isenović, E. R.. (2011). Opšte osobine i efekti grelina na kardiovaskularni sistem. in Medicinska istraživanja, 45(4), 15-29.
https://hdl.handle.net/21.15107/rcub_vinar_10326

Sudar E, Stokić E, Nikolić D, Dobutović B, Soskić SS, Obradović MM, Tanasković S, Radak ĐJ, Isenović ER. Opšte osobine i efekti grelina na kardiovaskularni sistem. in Medicinska istraživanja. 2011;45(4):15-29.
https://hdl.handle.net/21.15107/rcub_vinar_10326 .

Sudar, Emina, Stokić, Edita, Nikolić, Dragana, Dobutović, Branislava, Soskić, Sanja S., Obradović, Milan M., Tanasković, Slobodan, Radak, Đorđe J., Isenović, Esma R., "Opšte osobine i efekti grelina na kardiovaskularni sistem" in Medicinska istraživanja, 45, no. 4 (2011):15-29,
https://hdl.handle.net/21.15107/rcub_vinar_10326 .

TY  - JOUR
AU  - Nikolić, Dragana
AU  - Gluvić, Zoran
AU  - Akšam, Slavica
AU  - Obradović, Milan M.
AU  - Dobutović, Branislava
AU  - Soskić, Sanja S.
AU  - Sudar, Emina
AU  - Trpković, Andreja
AU  - Isenović, Esma R.
PY  - 2011
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10327
AB  - Oksidativni stres (OxS) je skup poremećaja dinamičke ravnoteže prooksidanasa i antioksidanasa koji nastaje usled povećane produkcije slobodnih radikala (SR) ili usled smanjene aktivnosti antioksidativnog zaštitnog sistema (AOS). Bolest koja se, takođe, povezuje sa OxS je i diabetes mellitus (DM). DM karakteriše povećani nivo glukoze u cirkulaciji, kao i drugi biohemijski poremećaji koji nastaju kao posledica neadekvatne produkcije ili neadekvatnog dejstva insulina. Dijabetes tipa 1 (DMT1) je prototip autoimune bolesti sa intenzivnim OxS. Antioksidativni enzim katalaza (CAT) smanjuje produkciju vodonik-peroksida koji može biti veoma toksičan za ćelije pankreasa. Povećanje aktivnosti CAT u svim fazama DMT1 indirektno potvrđuje značaj OxS u nastanku ove bolesti. Visoko reaktivni SR, nastali uglavnom zbog hiperglikemije, izazivaju OxS što dodatno ubrzava razvoj i napredovanje DM kao i njegovih komplikacija koje su uzrokovane redukovanom aktivnošću AOS. Uprkos brojnim dokazima o štetnim posledicama OxS u DM, veliki broj kliničkih ispitivanja sa klasičnim antioksidansima, nažalost, nije pokazao efikasnost njihove primene u lečenju DM. Novi terapijski pristup, koji uključuje primenu kako standardnih tako i novih antioksidanasa, se predlaže u algoritmima lečenja DM. Važno je ukazati na značaj doze primenjenih antioksidanasa, obzirom da je dokazano da pojedinačne visoke doze mogu delovati prooksidaciono. Takođe, važna je i dozna uravnoteženost primenjenih antioksidanasa i antidijabetika, u cilju efikasnijeg lečenja obolelih od DM. U okviru ovog rada fokusirali smo se na ulogu antioksidansa u lečenju DM.
AB  - Oxidative stress (OxS) represents an imbalance in dynamic equilibrium between prooxidants and antioxidants caused by increased free radical (FR) production or decreased activity of antioxidative system (AOS). OxS is involvedin many diseases such is diabetes mellitus (DM). DM presents with elevated blood glucose level and other biochemical disorders related to the inappropriate insulin secretion or improper insulin action. DM type 1 (DMT1) is an autoimmune disease with excessive OxS. The activity of antioxidative enzyme catalase (CAT) diminishes the production of hydrogen peroxide which is highly toxic for pancreatic cells. The increased activity of catalase (CAT) found in DMT1 patients signifies the importance of OxS in the pathogenesis of this disease. The generation of highly reactive FR, induced by hyperglycaemia, triggers the development of oxidative stress. Furthermore, OxS accelerates the development of DM and its complications which are related to the decreased activity of AOS. However, the standard antioxidant drugs failed in clinical trials for DM. New antioxidant agents combined with standard drugs are now proposed in therapy for DM. It is important to acknowledge that high doses of antioxidant agents could paradoxically have prooxidant effect. In addition, it is important to establish the dosage balance between antioxidant and antidiabetic drugs. In this article, we discuss the antioxidative agents and their significance in treatment of DM.
T2  - Medicinska istraživanja
T1  - Uloga antioksidanasa u lečenju diabetes mellitus-a
T1  - The role of antioxidative treatment in diabetes mellitus
VL  - 45
IS  - 2
SP  - 4
EP  - 12
UR  - https://hdl.handle.net/21.15107/rcub_vinar_10327
ER  - 

@article{
author = "Nikolić, Dragana and Gluvić, Zoran and Akšam, Slavica and Obradović, Milan M. and Dobutović, Branislava and Soskić, Sanja S. and Sudar, Emina and Trpković, Andreja and Isenović, Esma R.",
year = "2011",
abstract = "Oksidativni stres (OxS) je skup poremećaja dinamičke ravnoteže prooksidanasa i antioksidanasa koji nastaje usled povećane produkcije slobodnih radikala (SR) ili usled smanjene aktivnosti antioksidativnog zaštitnog sistema (AOS). Bolest koja se, takođe, povezuje sa OxS je i diabetes mellitus (DM). DM karakteriše povećani nivo glukoze u cirkulaciji, kao i drugi biohemijski poremećaji koji nastaju kao posledica neadekvatne produkcije ili neadekvatnog dejstva insulina. Dijabetes tipa 1 (DMT1) je prototip autoimune bolesti sa intenzivnim OxS. Antioksidativni enzim katalaza (CAT) smanjuje produkciju vodonik-peroksida koji može biti veoma toksičan za ćelije pankreasa. Povećanje aktivnosti CAT u svim fazama DMT1 indirektno potvrđuje značaj OxS u nastanku ove bolesti. Visoko reaktivni SR, nastali uglavnom zbog hiperglikemije, izazivaju OxS što dodatno ubrzava razvoj i napredovanje DM kao i njegovih komplikacija koje su uzrokovane redukovanom aktivnošću AOS. Uprkos brojnim dokazima o štetnim posledicama OxS u DM, veliki broj kliničkih ispitivanja sa klasičnim antioksidansima, nažalost, nije pokazao efikasnost njihove primene u lečenju DM. Novi terapijski pristup, koji uključuje primenu kako standardnih tako i novih antioksidanasa, se predlaže u algoritmima lečenja DM. Važno je ukazati na značaj doze primenjenih antioksidanasa, obzirom da je dokazano da pojedinačne visoke doze mogu delovati prooksidaciono. Takođe, važna je i dozna uravnoteženost primenjenih antioksidanasa i antidijabetika, u cilju efikasnijeg lečenja obolelih od DM. U okviru ovog rada fokusirali smo se na ulogu antioksidansa u lečenju DM., Oxidative stress (OxS) represents an imbalance in dynamic equilibrium between prooxidants and antioxidants caused by increased free radical (FR) production or decreased activity of antioxidative system (AOS). OxS is involvedin many diseases such is diabetes mellitus (DM). DM presents with elevated blood glucose level and other biochemical disorders related to the inappropriate insulin secretion or improper insulin action. DM type 1 (DMT1) is an autoimmune disease with excessive OxS. The activity of antioxidative enzyme catalase (CAT) diminishes the production of hydrogen peroxide which is highly toxic for pancreatic cells. The increased activity of catalase (CAT) found in DMT1 patients signifies the importance of OxS in the pathogenesis of this disease. The generation of highly reactive FR, induced by hyperglycaemia, triggers the development of oxidative stress. Furthermore, OxS accelerates the development of DM and its complications which are related to the decreased activity of AOS. However, the standard antioxidant drugs failed in clinical trials for DM. New antioxidant agents combined with standard drugs are now proposed in therapy for DM. It is important to acknowledge that high doses of antioxidant agents could paradoxically have prooxidant effect. In addition, it is important to establish the dosage balance between antioxidant and antidiabetic drugs. In this article, we discuss the antioxidative agents and their significance in treatment of DM.",
journal = "Medicinska istraživanja",
title = "Uloga antioksidanasa u lečenju diabetes mellitus-a, The role of antioxidative treatment in diabetes mellitus",
volume = "45",
number = "2",
pages = "4-12",
url = "https://hdl.handle.net/21.15107/rcub_vinar_10327"
}

Nikolić, D., Gluvić, Z., Akšam, S., Obradović, M. M., Dobutović, B., Soskić, S. S., Sudar, E., Trpković, A.,& Isenović, E. R.. (2011). Uloga antioksidanasa u lečenju diabetes mellitus-a. in Medicinska istraživanja, 45(2), 4-12.
https://hdl.handle.net/21.15107/rcub_vinar_10327

Nikolić D, Gluvić Z, Akšam S, Obradović MM, Dobutović B, Soskić SS, Sudar E, Trpković A, Isenović ER. Uloga antioksidanasa u lečenju diabetes mellitus-a. in Medicinska istraživanja. 2011;45(2):4-12.
https://hdl.handle.net/21.15107/rcub_vinar_10327 .

Nikolić, Dragana, Gluvić, Zoran, Akšam, Slavica, Obradović, Milan M., Dobutović, Branislava, Soskić, Sanja S., Sudar, Emina, Trpković, Andreja, Isenović, Esma R., "Uloga antioksidanasa u lečenju diabetes mellitus-a" in Medicinska istraživanja, 45, no. 2 (2011):4-12,
https://hdl.handle.net/21.15107/rcub_vinar_10327 .

TY  - JOUR
AU  - Smiljanić, Katarina
AU  - Dobutovic, B.
AU  - Obradović, Milan M.
AU  - Nikolić, Dragana
AU  - Marche, Pierre
AU  - Isenović, Esma R.
PY  - 2011
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/4468
AB  - Cardiovascular disease is the largest single cause of mortality and its major underlying pathology is atherosclerosis. The proliferation of vascular smooth muscle cells (VSMCs) is a key event in the pathogenesis of the various vascular diseases, including atherosclerosis and hypertension. Thrombin (Thr) is involved in the abnormal proliferation of VSMCs associated with atherosclerosis and hypertension. ADAMs (A Disintegrin And Metalloproteinase) are transmembrane metalloproteinases, belonging to the adamalysins group, that are distinct from matrix metalloproteinases (MMPs) in a way as they have an extracellular disintegrin domain and cytoplasmic domain that can associate with intracellular proteins. There is limited knowledge about the presence of ADAM metalloproteinase activity in Thr-induced VSMCs proliferation. Therefore, this review examines recent findings in signaling mechanisms employed by Thr in modulating the regulation of proliferation of VSMCs with particular emphasis on involvement of ADAM 12 which has been identified as an important mediator of VSMCs hypertrophy and vascular diseases. These findings are critical for understanding the role of Thr in vascular biology and vascular diseases.
T2  - Current Medicinal Chemistry
T1  - Involvement of the ADAM 12 in Thrombin-Induced Rats VSMCs Proliferation
VL  - 18
IS  - 22
SP  - 3382
EP  - 3386
DO  - 10.2174/092986711796504709
ER  - 

@article{
author = "Smiljanić, Katarina and Dobutovic, B. and Obradović, Milan M. and Nikolić, Dragana and Marche, Pierre and Isenović, Esma R.",
year = "2011",
abstract = "Cardiovascular disease is the largest single cause of mortality and its major underlying pathology is atherosclerosis. The proliferation of vascular smooth muscle cells (VSMCs) is a key event in the pathogenesis of the various vascular diseases, including atherosclerosis and hypertension. Thrombin (Thr) is involved in the abnormal proliferation of VSMCs associated with atherosclerosis and hypertension. ADAMs (A Disintegrin And Metalloproteinase) are transmembrane metalloproteinases, belonging to the adamalysins group, that are distinct from matrix metalloproteinases (MMPs) in a way as they have an extracellular disintegrin domain and cytoplasmic domain that can associate with intracellular proteins. There is limited knowledge about the presence of ADAM metalloproteinase activity in Thr-induced VSMCs proliferation. Therefore, this review examines recent findings in signaling mechanisms employed by Thr in modulating the regulation of proliferation of VSMCs with particular emphasis on involvement of ADAM 12 which has been identified as an important mediator of VSMCs hypertrophy and vascular diseases. These findings are critical for understanding the role of Thr in vascular biology and vascular diseases.",
journal = "Current Medicinal Chemistry",
title = "Involvement of the ADAM 12 in Thrombin-Induced Rats VSMCs Proliferation",
volume = "18",
number = "22",
pages = "3382-3386",
doi = "10.2174/092986711796504709"
}

Smiljanić, K., Dobutovic, B., Obradović, M. M., Nikolić, D., Marche, P.,& Isenović, E. R.. (2011). Involvement of the ADAM 12 in Thrombin-Induced Rats VSMCs Proliferation. in Current Medicinal Chemistry, 18(22), 3382-3386.
https://doi.org/10.2174/092986711796504709

Smiljanić K, Dobutovic B, Obradović MM, Nikolić D, Marche P, Isenović ER. Involvement of the ADAM 12 in Thrombin-Induced Rats VSMCs Proliferation. in Current Medicinal Chemistry. 2011;18(22):3382-3386.
doi:10.2174/092986711796504709 .

Smiljanić, Katarina, Dobutovic, B., Obradović, Milan M., Nikolić, Dragana, Marche, Pierre, Isenović, Esma R., "Involvement of the ADAM 12 in Thrombin-Induced Rats VSMCs Proliferation" in Current Medicinal Chemistry, 18, no. 22 (2011):3382-3386,
https://doi.org/10.2174/092986711796504709 . .

TY  - JOUR
AU  - Soskić, Sanja S.
AU  - Dobutović, Branislava
AU  - Sudar, Emina
AU  - Obradović, Milan M.
AU  - Nikolić, Dragana
AU  - Zarić, Božidarka
AU  - Stojanovic, Srdan D.
AU  - Stokić, Edita
AU  - Mikhailidis, Dimitri P.
AU  - Isenović, Esma R.
PY  - 2011
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/4519
AB  - The peroxisome proliferator-activated receptors (PPARs) represent the family of 3 nuclear receptor isoforms-PPAR alpha, -gamma, and -delta/beta, which are encoded by different genes. As lipid sensors, they are primarily involved in regulation of lipid metabolism and subsequently in inflammation and atherosclerosis. Atherosclerosis considers accumulation of the cells and extracellular matrix in the vessel wall leading to the formation of atherosclerotic plaque, atherothrombosis, and other vascular complications. Besides existence of natural ligands for PPARs, their more potent synthetic ligands are fibrates and thiazolidindiones. Future investigations should now focus on the mechanisms of PPARs activation, which might present new approaches involved in the antiatherosclerotic effects revealed in this review. In addition, in this review we are presenting latest data from recent performed clinical studies which have focus on novel approach to PPARs agonists as potential therapeutic agents in the treatment of complex disease such as atherosclerosis.
T2  - Angiology
T1  - Peroxisome Proliferator-Activated Receptors and Atherosclerosis
VL  - 62
IS  - 7
SP  - 523
EP  - 534
DO  - 10.1177/0003319711401012
ER  - 

@article{
author = "Soskić, Sanja S. and Dobutović, Branislava and Sudar, Emina and Obradović, Milan M. and Nikolić, Dragana and Zarić, Božidarka and Stojanovic, Srdan D. and Stokić, Edita and Mikhailidis, Dimitri P. and Isenović, Esma R.",
year = "2011",
abstract = "The peroxisome proliferator-activated receptors (PPARs) represent the family of 3 nuclear receptor isoforms-PPAR alpha, -gamma, and -delta/beta, which are encoded by different genes. As lipid sensors, they are primarily involved in regulation of lipid metabolism and subsequently in inflammation and atherosclerosis. Atherosclerosis considers accumulation of the cells and extracellular matrix in the vessel wall leading to the formation of atherosclerotic plaque, atherothrombosis, and other vascular complications. Besides existence of natural ligands for PPARs, their more potent synthetic ligands are fibrates and thiazolidindiones. Future investigations should now focus on the mechanisms of PPARs activation, which might present new approaches involved in the antiatherosclerotic effects revealed in this review. In addition, in this review we are presenting latest data from recent performed clinical studies which have focus on novel approach to PPARs agonists as potential therapeutic agents in the treatment of complex disease such as atherosclerosis.",
journal = "Angiology",
title = "Peroxisome Proliferator-Activated Receptors and Atherosclerosis",
volume = "62",
number = "7",
pages = "523-534",
doi = "10.1177/0003319711401012"
}

Soskić, S. S., Dobutović, B., Sudar, E., Obradović, M. M., Nikolić, D., Zarić, B., Stojanovic, S. D., Stokić, E., Mikhailidis, D. P.,& Isenović, E. R.. (2011). Peroxisome Proliferator-Activated Receptors and Atherosclerosis. in Angiology, 62(7), 523-534.
https://doi.org/10.1177/0003319711401012

Soskić SS, Dobutović B, Sudar E, Obradović MM, Nikolić D, Zarić B, Stojanovic SD, Stokić E, Mikhailidis DP, Isenović ER. Peroxisome Proliferator-Activated Receptors and Atherosclerosis. in Angiology. 2011;62(7):523-534.
doi:10.1177/0003319711401012 .

Soskić, Sanja S., Dobutović, Branislava, Sudar, Emina, Obradović, Milan M., Nikolić, Dragana, Zarić, Božidarka, Stojanovic, Srdan D., Stokić, Edita, Mikhailidis, Dimitri P., Isenović, Esma R., "Peroxisome Proliferator-Activated Receptors and Atherosclerosis" in Angiology, 62, no. 7 (2011):523-534,
https://doi.org/10.1177/0003319711401012 . .