TY  - JOUR
AU  - Satarić, Miljko V.
AU  - Nemeš, Tomas
AU  - Satarić, Bogdan
AU  - Sekulić, Dalibor
AU  - Zdravković, Slobodan
PY  - 2020
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/9059
AB  - The cytoskeleton of cilia and flagella is so called axoneme a stable cylindrical architecture of nine microtubule doublets. Axoneme performs periodic bending motion by utilizing specific dynein motor family powered by ATP hydrolysis. It is still unclear how this highly organized “ciliary beat” is being initiated and strongly coordinated by the combined action of hundreds dynein motors. Based on the experimental evidences we here elaborate a plausible scenario in which actually calcium ions play the roles of catalytic activators and coordinators of dynein attachments doing it in superposition with already known mechanical control tools of “ciliary beat”. Polyelectrolyte properties of microtubules incorporated in axoneme doublets enable the formation and propagation of soliton-like “ionic clouds” of Ca2+ ions along these “coaxial nanocables”. The sliding speed of such Ca2+ “clouds” along microtubule doublets is comparable with the speed of propagation of “ciliary beat” itself. We elaborated the interplay between influx of Ca2+ ions in ciliary based body and the sliding of microtubule triplets therein. In second segment we considered how the dynein motors activated by Ca2+ ions contained within solitonic “ionic clouds” in competition with axoneme curvature regulate ciliary and flagellar beating.
T2  - Biosystems
T1  - Calcium ions tune the beats of cilia and flagella
VL  - 196
SP  - 104172
DO  - 10.1016/j.biosystems.2020.104172
ER  - 

@article{
author = "Satarić, Miljko V. and Nemeš, Tomas and Satarić, Bogdan and Sekulić, Dalibor and Zdravković, Slobodan",
year = "2020",
abstract = "The cytoskeleton of cilia and flagella is so called axoneme a stable cylindrical architecture of nine microtubule doublets. Axoneme performs periodic bending motion by utilizing specific dynein motor family powered by ATP hydrolysis. It is still unclear how this highly organized “ciliary beat” is being initiated and strongly coordinated by the combined action of hundreds dynein motors. Based on the experimental evidences we here elaborate a plausible scenario in which actually calcium ions play the roles of catalytic activators and coordinators of dynein attachments doing it in superposition with already known mechanical control tools of “ciliary beat”. Polyelectrolyte properties of microtubules incorporated in axoneme doublets enable the formation and propagation of soliton-like “ionic clouds” of Ca2+ ions along these “coaxial nanocables”. The sliding speed of such Ca2+ “clouds” along microtubule doublets is comparable with the speed of propagation of “ciliary beat” itself. We elaborated the interplay between influx of Ca2+ ions in ciliary based body and the sliding of microtubule triplets therein. In second segment we considered how the dynein motors activated by Ca2+ ions contained within solitonic “ionic clouds” in competition with axoneme curvature regulate ciliary and flagellar beating.",
journal = "Biosystems",
title = "Calcium ions tune the beats of cilia and flagella",
volume = "196",
pages = "104172",
doi = "10.1016/j.biosystems.2020.104172"
}

Satarić, M. V., Nemeš, T., Satarić, B., Sekulić, D.,& Zdravković, S.. (2020). Calcium ions tune the beats of cilia and flagella. in Biosystems, 196, 104172.
https://doi.org/10.1016/j.biosystems.2020.104172

Satarić MV, Nemeš T, Satarić B, Sekulić D, Zdravković S. Calcium ions tune the beats of cilia and flagella. in Biosystems. 2020;196:104172.
doi:10.1016/j.biosystems.2020.104172 .

Satarić, Miljko V., Nemeš, Tomas, Satarić, Bogdan, Sekulić, Dalibor, Zdravković, Slobodan, "Calcium ions tune the beats of cilia and flagella" in Biosystems, 196 (2020):104172,
https://doi.org/10.1016/j.biosystems.2020.104172 . .

TY  - JOUR
AU  - Tuszynski, Jack A.
AU  - Satarić, Miljko V.
AU  - Sekulić, Dalibor L.
AU  - Satarić, Bogdan M.
AU  - Zdravković, Slobodan
PY  - 2018
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/8397
AB  - Calcium ions (Ca2+) tune and control numerous diverse aspects of cochlear and vestibular physiological processes. This paper is focused on the Ca2+ control of mechanotransduction in sensory hair cells in the context of polyelectrolyte properties of actin filaments within the hair–bundles of inner ear. These actin filaments appear to serve as efficient pathways for the flow of Ca2+ ions inside stereocilia. We showed how this can be utilized for tuning of force–generating myosin motors. In an established model, we unified the Ca2+ nonlinear dynamics involved in the control of myosin adaptation motors with mechanical displacements of hair–bundles. The model shows that the characteristic time scales fit reasonably well with the available experimental data for spontaneous oscillations in the inner ear. This scenario promises to fill a gap in our understanding of the role of Ca2+ ions in the regulation of processes in the auditory cells of the inner ear. © 2018 Elsevier B.V.
T2  - Biosystems
T1  - Nonlinear calcium ion waves along actin filaments control active hair–bundle motility
VL  - 173
SP  - 181
EP  - 190
DO  - 10.1016/j.biosystems.2018.08.006
ER  - 

@article{
author = "Tuszynski, Jack A. and Satarić, Miljko V. and Sekulić, Dalibor L. and Satarić, Bogdan M. and Zdravković, Slobodan",
year = "2018",
abstract = "Calcium ions (Ca2+) tune and control numerous diverse aspects of cochlear and vestibular physiological processes. This paper is focused on the Ca2+ control of mechanotransduction in sensory hair cells in the context of polyelectrolyte properties of actin filaments within the hair–bundles of inner ear. These actin filaments appear to serve as efficient pathways for the flow of Ca2+ ions inside stereocilia. We showed how this can be utilized for tuning of force–generating myosin motors. In an established model, we unified the Ca2+ nonlinear dynamics involved in the control of myosin adaptation motors with mechanical displacements of hair–bundles. The model shows that the characteristic time scales fit reasonably well with the available experimental data for spontaneous oscillations in the inner ear. This scenario promises to fill a gap in our understanding of the role of Ca2+ ions in the regulation of processes in the auditory cells of the inner ear. © 2018 Elsevier B.V.",
journal = "Biosystems",
title = "Nonlinear calcium ion waves along actin filaments control active hair–bundle motility",
volume = "173",
pages = "181-190",
doi = "10.1016/j.biosystems.2018.08.006"
}

Tuszynski, J. A., Satarić, M. V., Sekulić, D. L., Satarić, B. M.,& Zdravković, S.. (2018). Nonlinear calcium ion waves along actin filaments control active hair–bundle motility. in Biosystems, 173, 181-190.
https://doi.org/10.1016/j.biosystems.2018.08.006

Tuszynski JA, Satarić MV, Sekulić DL, Satarić BM, Zdravković S. Nonlinear calcium ion waves along actin filaments control active hair–bundle motility. in Biosystems. 2018;173:181-190.
doi:10.1016/j.biosystems.2018.08.006 .

Tuszynski, Jack A., Satarić, Miljko V., Sekulić, Dalibor L., Satarić, Bogdan M., Zdravković, Slobodan, "Nonlinear calcium ion waves along actin filaments control active hair–bundle motility" in Biosystems, 173 (2018):181-190,
https://doi.org/10.1016/j.biosystems.2018.08.006 . .

TY  - JOUR
AU  - Sekulić, Dalibor L.
AU  - Satarić, Bogdan M.
AU  - Zdravković, Slobodan
AU  - Bugay, Aleksandr N.
AU  - Satarić, Miljko V.
PY  - 2016
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/1225
AB  - The mechanical and electrical properties, and information processing capabilities of microtubules are the permanent subject of interest for carrying out experiments in vitro and in silico, as well as for theoretical attempts to elucidate the underlying processes. In this paper, we developed a new model of the mechano-electrical waves elicited in the rows of very flexible C-terminal tails which decorate the outer surface of each microtubule. The fact that C-terminal tails play very diverse roles in many cellular functions, such as recruitment of motor proteins and microtubule-associated proteins, motivated us to consider their collective dynamics as the source of localized waves aimed for communication between microtubule and associated proteins. Our approach is based on the ferroelectric liquid crystal model and it leads to the effective asymmetric double-well potential which brings about the conditions for the appearance of kink-waves conducted by intrinsic electric fields embedded in microtubules. These kinks can serve as the signals for control and regulation of intracellular traffic along microtubules performed by processive motions of motor proteins, primarly from kinesin and dynein families. On the other hand, they can be precursors for initiation of dynamical instability of microtubules by recruiting the proper proteins responsible for the depolymerization process. Published by AIP Publishing.
T2  - Chaos
T1  - Nonlinear dynamics of C-terminal tails in cellular microtubules
VL  - 26
IS  - 7
DO  - 10.1063/1.4959802
ER  - 

@article{
author = "Sekulić, Dalibor L. and Satarić, Bogdan M. and Zdravković, Slobodan and Bugay, Aleksandr N. and Satarić, Miljko V.",
year = "2016",
abstract = "The mechanical and electrical properties, and information processing capabilities of microtubules are the permanent subject of interest for carrying out experiments in vitro and in silico, as well as for theoretical attempts to elucidate the underlying processes. In this paper, we developed a new model of the mechano-electrical waves elicited in the rows of very flexible C-terminal tails which decorate the outer surface of each microtubule. The fact that C-terminal tails play very diverse roles in many cellular functions, such as recruitment of motor proteins and microtubule-associated proteins, motivated us to consider their collective dynamics as the source of localized waves aimed for communication between microtubule and associated proteins. Our approach is based on the ferroelectric liquid crystal model and it leads to the effective asymmetric double-well potential which brings about the conditions for the appearance of kink-waves conducted by intrinsic electric fields embedded in microtubules. These kinks can serve as the signals for control and regulation of intracellular traffic along microtubules performed by processive motions of motor proteins, primarly from kinesin and dynein families. On the other hand, they can be precursors for initiation of dynamical instability of microtubules by recruiting the proper proteins responsible for the depolymerization process. Published by AIP Publishing.",
journal = "Chaos",
title = "Nonlinear dynamics of C-terminal tails in cellular microtubules",
volume = "26",
number = "7",
doi = "10.1063/1.4959802"
}

Sekulić, D. L., Satarić, B. M., Zdravković, S., Bugay, A. N.,& Satarić, M. V.. (2016). Nonlinear dynamics of C-terminal tails in cellular microtubules. in Chaos, 26(7).
https://doi.org/10.1063/1.4959802

Sekulić DL, Satarić BM, Zdravković S, Bugay AN, Satarić MV. Nonlinear dynamics of C-terminal tails in cellular microtubules. in Chaos. 2016;26(7).
doi:10.1063/1.4959802 .

Sekulić, Dalibor L., Satarić, Bogdan M., Zdravković, Slobodan, Bugay, Aleksandr N., Satarić, Miljko V., "Nonlinear dynamics of C-terminal tails in cellular microtubules" in Chaos, 26, no. 7 (2016),
https://doi.org/10.1063/1.4959802 . .

TY  - JOUR
AU  - Satarić, Miljko V.
AU  - Sekulić, Dalibor L.
AU  - Satarić, Bogdan M.
AU  - Zdravković, Slobodan
PY  - 2015
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/782
AB  - This paper aims to provide an overview of the polyelectrolyte model and the current understanding of the creation and propagation of localized pulses of positive ions flowing along cellular microtubules. In that context, Ca2+ ions may move freely on the surface of microtubule along the protofilament axis, thus leading to signal transport. Special emphasis in this paper is placed on the possible role of this mechanism in the function of microtubule based kinocilium, a component of vestibular hair cells of the inner ear. We discuss how localized pulses of Ca2+ ions play a crucial role in tuning the activity of dynein motors, which are involved in mechano sensitivity of the kinocilium. A prevailing notion holds that the concentration of Ca2+ ions around the microtubules within the kinocilium represents the control parameter for Hopf bifurcation. Therefore, a key feature of this mechanism is that the velocities of these Ca2+ pulses be sufficiently high to exert control at acoustic frequencies. (C) 2015 Elsevier Ltd. All rights reserved.
T2  - Progress in Biophysics and Molecular Biology
T1  - Role of nonlinear localized Ca2+ pulses along microtubules in tuning the mechano-sensitivity of hair cells
VL  - 119
IS  - 2
SP  - 162
EP  - 174
DO  - 10.1016/j.pbiomolbio.2015.07.009
ER  - 

@article{
author = "Satarić, Miljko V. and Sekulić, Dalibor L. and Satarić, Bogdan M. and Zdravković, Slobodan",
year = "2015",
abstract = "This paper aims to provide an overview of the polyelectrolyte model and the current understanding of the creation and propagation of localized pulses of positive ions flowing along cellular microtubules. In that context, Ca2+ ions may move freely on the surface of microtubule along the protofilament axis, thus leading to signal transport. Special emphasis in this paper is placed on the possible role of this mechanism in the function of microtubule based kinocilium, a component of vestibular hair cells of the inner ear. We discuss how localized pulses of Ca2+ ions play a crucial role in tuning the activity of dynein motors, which are involved in mechano sensitivity of the kinocilium. A prevailing notion holds that the concentration of Ca2+ ions around the microtubules within the kinocilium represents the control parameter for Hopf bifurcation. Therefore, a key feature of this mechanism is that the velocities of these Ca2+ pulses be sufficiently high to exert control at acoustic frequencies. (C) 2015 Elsevier Ltd. All rights reserved.",
journal = "Progress in Biophysics and Molecular Biology",
title = "Role of nonlinear localized Ca2+ pulses along microtubules in tuning the mechano-sensitivity of hair cells",
volume = "119",
number = "2",
pages = "162-174",
doi = "10.1016/j.pbiomolbio.2015.07.009"
}

Satarić, M. V., Sekulić, D. L., Satarić, B. M.,& Zdravković, S.. (2015). Role of nonlinear localized Ca2+ pulses along microtubules in tuning the mechano-sensitivity of hair cells. in Progress in Biophysics and Molecular Biology, 119(2), 162-174.
https://doi.org/10.1016/j.pbiomolbio.2015.07.009

Satarić MV, Sekulić DL, Satarić BM, Zdravković S. Role of nonlinear localized Ca2+ pulses along microtubules in tuning the mechano-sensitivity of hair cells. in Progress in Biophysics and Molecular Biology. 2015;119(2):162-174.
doi:10.1016/j.pbiomolbio.2015.07.009 .

Satarić, Miljko V., Sekulić, Dalibor L., Satarić, Bogdan M., Zdravković, Slobodan, "Role of nonlinear localized Ca2+ pulses along microtubules in tuning the mechano-sensitivity of hair cells" in Progress in Biophysics and Molecular Biology, 119, no. 2 (2015):162-174,
https://doi.org/10.1016/j.pbiomolbio.2015.07.009 . .