TY  - JOUR
AU  - Mitrović, Marko B.
AU  - Tatalović, Nikola R.
AU  - Nikolić-Kokić, Aleksandra L.
AU  - Ciraj-Bjelac, Olivera
AU  - Krstić, Nikola E.
AU  - Oreščanin-Dušić, Zorana S.
AU  - Krstić, Dragana Ž.
AU  - Jovanović, Zoran M.
AU  - Blagojević, Duško P.
AU  - Lazarević-Macanović, Mirjana V.
PY  - 2018
UR  - http://www.doiserbia.nb.rs/Article.aspx?ID=0354-46641800029M
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/8001
AB  - In recent years, computed tomography (CT) has become very common in veterinary medicine. It is well known that testicles are organs with high radiosensitivity and their function can be impaired even after exposure to low radiation doses. In this work, we calculated the absorbed radiation doses after CT was performed with different voltage/current levels and correlated it with the activity of antioxidant enzymes in rabbit testicles. Two hours after CT, the activities of catalase (CAT) and glutathione peroxidase (GSH-Px) were increased in the testicles of animals that received an absorbed dose of 29.2 mGy. The same changes, along with elevated glutathione reductase (GR) activity, were observed after 7 days in animals that received the highest absorbed dose (46.3 mGy). It would appear that absorbed doses above 27.8 mGy provoked the antioxidant reaction but the time scale of the reaction was dose-dependent. Examination of the obtained results revealed that the main denominator of CT influence was a higher current. Our results suggest that CT influences the antioxidant status in rabbit testicles. The changes in antioxidant enzyme activities were dose- and time-dependent and influenced by the applied current. © 2018 by the Serbian Biological Society.
T2  - Archives of Biological Sciences
T1  - Influence of absorbed radiation dose following computed tomography on the antioxidative status in rabbit testicles
VL  - 70
IS  - 4
SP  - 675
EP  - 680
DO  - 10.2298/ABS180413029M
ER  - 

@article{
author = "Mitrović, Marko B. and Tatalović, Nikola R. and Nikolić-Kokić, Aleksandra L. and Ciraj-Bjelac, Olivera and Krstić, Nikola E. and Oreščanin-Dušić, Zorana S. and Krstić, Dragana Ž. and Jovanović, Zoran M. and Blagojević, Duško P. and Lazarević-Macanović, Mirjana V.",
year = "2018",
abstract = "In recent years, computed tomography (CT) has become very common in veterinary medicine. It is well known that testicles are organs with high radiosensitivity and their function can be impaired even after exposure to low radiation doses. In this work, we calculated the absorbed radiation doses after CT was performed with different voltage/current levels and correlated it with the activity of antioxidant enzymes in rabbit testicles. Two hours after CT, the activities of catalase (CAT) and glutathione peroxidase (GSH-Px) were increased in the testicles of animals that received an absorbed dose of 29.2 mGy. The same changes, along with elevated glutathione reductase (GR) activity, were observed after 7 days in animals that received the highest absorbed dose (46.3 mGy). It would appear that absorbed doses above 27.8 mGy provoked the antioxidant reaction but the time scale of the reaction was dose-dependent. Examination of the obtained results revealed that the main denominator of CT influence was a higher current. Our results suggest that CT influences the antioxidant status in rabbit testicles. The changes in antioxidant enzyme activities were dose- and time-dependent and influenced by the applied current. © 2018 by the Serbian Biological Society.",
journal = "Archives of Biological Sciences",
title = "Influence of absorbed radiation dose following computed tomography on the antioxidative status in rabbit testicles",
volume = "70",
number = "4",
pages = "675-680",
doi = "10.2298/ABS180413029M"
}

Mitrović, M. B., Tatalović, N. R., Nikolić-Kokić, A. L., Ciraj-Bjelac, O., Krstić, N. E., Oreščanin-Dušić, Z. S., Krstić, D. Ž., Jovanović, Z. M., Blagojević, D. P.,& Lazarević-Macanović, M. V.. (2018). Influence of absorbed radiation dose following computed tomography on the antioxidative status in rabbit testicles. in Archives of Biological Sciences, 70(4), 675-680.
https://doi.org/10.2298/ABS180413029M

Mitrović MB, Tatalović NR, Nikolić-Kokić AL, Ciraj-Bjelac O, Krstić NE, Oreščanin-Dušić ZS, Krstić DŽ, Jovanović ZM, Blagojević DP, Lazarević-Macanović MV. Influence of absorbed radiation dose following computed tomography on the antioxidative status in rabbit testicles. in Archives of Biological Sciences. 2018;70(4):675-680.
doi:10.2298/ABS180413029M .

Mitrović, Marko B., Tatalović, Nikola R., Nikolić-Kokić, Aleksandra L., Ciraj-Bjelac, Olivera, Krstić, Nikola E., Oreščanin-Dušić, Zorana S., Krstić, Dragana Ž., Jovanović, Zoran M., Blagojević, Duško P., Lazarević-Macanović, Mirjana V., "Influence of absorbed radiation dose following computed tomography on the antioxidative status in rabbit testicles" in Archives of Biological Sciences, 70, no. 4 (2018):675-680,
https://doi.org/10.2298/ABS180413029M . .

TY  - JOUR
AU  - Mitrović, Marko B.
AU  - Ciraj-Bjelac, Olivera
AU  - Oreščanin-Dušić, Zorana S.
AU  - Blagojević, Duško P.
AU  - Nikolić-Kokić, Aleksandra L.
AU  - Tatalović, Nikola R.
AU  - Krstić, Nikola E.
AU  - Lazarević-Macanović, Mirjana V.
PY  - 2017
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/1934
AB  - The objective of this study was to assess the radiation dose in computed tomography examinations of rabbits using different examination protocols and to correlate these values with the activity of antioxidant enzymes in their red blood cells following irradiation. The presented results revealed that a single, routine computed tomography scan exposure led to a different response of the activity of antioxidant enzymes in red blood cells regarding both dose and time. The results indicate that there is a dose threshold that is about 25 mGy. Doses below that level do not produce any significant changes in the level of antioxidant enzymes activity. On the other hand, the level just above that threshold had a significant impact on the antioxidant defence, but in a relatively short time period (2 hours after exposure), compared to the higher dose that requires a longer adaptive period.
T2  - Nuclear technology and radiation protection
T1  - Influence of Radiation Dose in Computed Tomography on Antioxidant Enzyme Activity in Rabbit Erythrocytes
VL  - 32
IS  - 4
SP  - 342
EP  - 349
DO  - 10.2298/NTRP1704342M
ER  - 

@article{
author = "Mitrović, Marko B. and Ciraj-Bjelac, Olivera and Oreščanin-Dušić, Zorana S. and Blagojević, Duško P. and Nikolić-Kokić, Aleksandra L. and Tatalović, Nikola R. and Krstić, Nikola E. and Lazarević-Macanović, Mirjana V.",
year = "2017",
abstract = "The objective of this study was to assess the radiation dose in computed tomography examinations of rabbits using different examination protocols and to correlate these values with the activity of antioxidant enzymes in their red blood cells following irradiation. The presented results revealed that a single, routine computed tomography scan exposure led to a different response of the activity of antioxidant enzymes in red blood cells regarding both dose and time. The results indicate that there is a dose threshold that is about 25 mGy. Doses below that level do not produce any significant changes in the level of antioxidant enzymes activity. On the other hand, the level just above that threshold had a significant impact on the antioxidant defence, but in a relatively short time period (2 hours after exposure), compared to the higher dose that requires a longer adaptive period.",
journal = "Nuclear technology and radiation protection",
title = "Influence of Radiation Dose in Computed Tomography on Antioxidant Enzyme Activity in Rabbit Erythrocytes",
volume = "32",
number = "4",
pages = "342-349",
doi = "10.2298/NTRP1704342M"
}

Mitrović, M. B., Ciraj-Bjelac, O., Oreščanin-Dušić, Z. S., Blagojević, D. P., Nikolić-Kokić, A. L., Tatalović, N. R., Krstić, N. E.,& Lazarević-Macanović, M. V.. (2017). Influence of Radiation Dose in Computed Tomography on Antioxidant Enzyme Activity in Rabbit Erythrocytes. in Nuclear technology and radiation protection, 32(4), 342-349.
https://doi.org/10.2298/NTRP1704342M

Mitrović MB, Ciraj-Bjelac O, Oreščanin-Dušić ZS, Blagojević DP, Nikolić-Kokić AL, Tatalović NR, Krstić NE, Lazarević-Macanović MV. Influence of Radiation Dose in Computed Tomography on Antioxidant Enzyme Activity in Rabbit Erythrocytes. in Nuclear technology and radiation protection. 2017;32(4):342-349.
doi:10.2298/NTRP1704342M .

Mitrović, Marko B., Ciraj-Bjelac, Olivera, Oreščanin-Dušić, Zorana S., Blagojević, Duško P., Nikolić-Kokić, Aleksandra L., Tatalović, Nikola R., Krstić, Nikola E., Lazarević-Macanović, Mirjana V., "Influence of Radiation Dose in Computed Tomography on Antioxidant Enzyme Activity in Rabbit Erythrocytes" in Nuclear technology and radiation protection, 32, no. 4 (2017):342-349,
https://doi.org/10.2298/NTRP1704342M . .

TY  - JOUR
AU  - Slavic, Marija
AU  - Đorđević, Aleksandar N.
AU  - Radojicic, Ratko
AU  - Milovanović, Slobodan
AU  - Oreščanin-Dušić, Zorana S.
AU  - Rakočević, Zlatko Lj.
AU  - Spasić, Mihajlo
AU  - Blagojević, Duško P.
PY  - 2013
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/5496
AB  - Dimethyl sulfoxide (DMSO) is a widely used solvent and cryoprotectant that can cause impaired blood flow, reduction in intracranial pressure, tissue edema, inflammatory reactions, inhibition of vascular smooth muscle cell migration and proliferation, processes which can lead to atherosclerosis of the coronary, peripheral and cerebral circulation. Although the adverse effects are rare when DMSO is administered in clinically established concentrations, there is no safe antagonist for an overdose. In this work, we treated isolated spontaneous and calcium-induced contractile active rat uteri (Wistar, virgo intacta), with DMSO and fullerenol C-60(OH)(24) nanoparticle (FNP) in DMSO. FNP is a water-soluble derivative of fullerene C-60. Its size is a 1.1 nm in diameter and is a very promising candidate for a drug carrier in nanomedicine. FNP also displays free radical scavenging activity. DMSO decreased both spontaneous and calcium-induced contractions. In contrast, FNP only decreased spontaneous contraction. FNP decreased copper-zinc superoxide dismutase activity and prevented the DMSO-induced increase in glutathione reductase activity. Atomic force microscopy detected that FNP aggregated with calcium ions. Our results indicate that FNP has properties that make it a good candidate to be a modulator of DMSO activity which could minimize side effects of the latter.
T2  - Journal of Nanoparticle Research
T1  - Fullerenol C-60(OH)(24) nanoparticles decrease relaxing effects of dimethyl sulfoxide on rat uterus spontaneous contraction
VL  - 15
IS  - 5
DO  - 10.1007/s11051-013-1650-1
ER  - 

@article{
author = "Slavic, Marija and Đorđević, Aleksandar N. and Radojicic, Ratko and Milovanović, Slobodan and Oreščanin-Dušić, Zorana S. and Rakočević, Zlatko Lj. and Spasić, Mihajlo and Blagojević, Duško P.",
year = "2013",
abstract = "Dimethyl sulfoxide (DMSO) is a widely used solvent and cryoprotectant that can cause impaired blood flow, reduction in intracranial pressure, tissue edema, inflammatory reactions, inhibition of vascular smooth muscle cell migration and proliferation, processes which can lead to atherosclerosis of the coronary, peripheral and cerebral circulation. Although the adverse effects are rare when DMSO is administered in clinically established concentrations, there is no safe antagonist for an overdose. In this work, we treated isolated spontaneous and calcium-induced contractile active rat uteri (Wistar, virgo intacta), with DMSO and fullerenol C-60(OH)(24) nanoparticle (FNP) in DMSO. FNP is a water-soluble derivative of fullerene C-60. Its size is a 1.1 nm in diameter and is a very promising candidate for a drug carrier in nanomedicine. FNP also displays free radical scavenging activity. DMSO decreased both spontaneous and calcium-induced contractions. In contrast, FNP only decreased spontaneous contraction. FNP decreased copper-zinc superoxide dismutase activity and prevented the DMSO-induced increase in glutathione reductase activity. Atomic force microscopy detected that FNP aggregated with calcium ions. Our results indicate that FNP has properties that make it a good candidate to be a modulator of DMSO activity which could minimize side effects of the latter.",
journal = "Journal of Nanoparticle Research",
title = "Fullerenol C-60(OH)(24) nanoparticles decrease relaxing effects of dimethyl sulfoxide on rat uterus spontaneous contraction",
volume = "15",
number = "5",
doi = "10.1007/s11051-013-1650-1"
}

Slavic, M., Đorđević, A. N., Radojicic, R., Milovanović, S., Oreščanin-Dušić, Z. S., Rakočević, Z. Lj., Spasić, M.,& Blagojević, D. P.. (2013). Fullerenol C-60(OH)(24) nanoparticles decrease relaxing effects of dimethyl sulfoxide on rat uterus spontaneous contraction. in Journal of Nanoparticle Research, 15(5).
https://doi.org/10.1007/s11051-013-1650-1

Slavic M, Đorđević AN, Radojicic R, Milovanović S, Oreščanin-Dušić ZS, Rakočević ZL, Spasić M, Blagojević DP. Fullerenol C-60(OH)(24) nanoparticles decrease relaxing effects of dimethyl sulfoxide on rat uterus spontaneous contraction. in Journal of Nanoparticle Research. 2013;15(5).
doi:10.1007/s11051-013-1650-1 .

Slavic, Marija, Đorđević, Aleksandar N., Radojicic, Ratko, Milovanović, Slobodan, Oreščanin-Dušić, Zorana S., Rakočević, Zlatko Lj., Spasić, Mihajlo, Blagojević, Duško P., "Fullerenol C-60(OH)(24) nanoparticles decrease relaxing effects of dimethyl sulfoxide on rat uterus spontaneous contraction" in Journal of Nanoparticle Research, 15, no. 5 (2013),
https://doi.org/10.1007/s11051-013-1650-1 . .