TY  - JOUR
AU  - Shaalan, Mohamed
AU  - Vykydalová, Anna
AU  - Švajdlenková, Helena
AU  - Kroneková, Zuzana
AU  - Marković, Zoran M.
AU  - Kováčová, Mária
AU  - Špitálský, Zdenko
PY  - 2024
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/13310
AB  - 3D printing provides a lot of varieties for the manufacturing of personalized biomedical devices. Incorporation of the nanoparticles with potential antibacterial activity to the printed materials is another added value. One example of such nanoparticles are hydrophobic carbon quantum dots (hCQDs), which are zero-dimensional redox-active materials with high chemical stability and low production costs. They produce singlet oxygen only when activated by a specific wavelength of visible blue light which allows for controlled antibacterial action and minimizes the chances of bacterial resistance emergence. We prepared and characterized polymer composites based on thermoplastic elastomers (TPE) doped with hCQDs (TPE/hCQDs). The composites were 3D printed using fused deposition modeling method. In the first set of samples, a filament of pure TPE was immersed in a solution of hCQDs (0.5 mg/mL), then 3D printed, and compared with unmodified TPE filament. The mechanical properties, swelling behavior, hardness, and thermal stability of TPE/hCQDs were compared with the pure TPE printed samples. The production of singlet oxygen was confirmed by the electron paramagnetic resonance method. The antibacterial activity of the samples was tested according to ISO 22196 against Staphylococcus aureus and Escherichia coli after one hour of exposure to blue light, which completely inhibited bacterial growth. Besides, the cytotoxicity of samples was evaluated by MTT assay, and no significant effect of the materials on cell viability was observed. 3D printed materials with antibacterial activity represent a perspective for the future, especially in the field of personalized medicine, as well as in products for other industries.
T2  - Polymer Bulletin
T1  - Antibacterial activity of 3D printed thermoplastic elastomers doped with carbon quantum dots for biomedical applications
DO  - 10.1007/s00289-024-05339-1
ER  - 

@article{
author = "Shaalan, Mohamed and Vykydalová, Anna and Švajdlenková, Helena and Kroneková, Zuzana and Marković, Zoran M. and Kováčová, Mária and Špitálský, Zdenko",
year = "2024",
abstract = "3D printing provides a lot of varieties for the manufacturing of personalized biomedical devices. Incorporation of the nanoparticles with potential antibacterial activity to the printed materials is another added value. One example of such nanoparticles are hydrophobic carbon quantum dots (hCQDs), which are zero-dimensional redox-active materials with high chemical stability and low production costs. They produce singlet oxygen only when activated by a specific wavelength of visible blue light which allows for controlled antibacterial action and minimizes the chances of bacterial resistance emergence. We prepared and characterized polymer composites based on thermoplastic elastomers (TPE) doped with hCQDs (TPE/hCQDs). The composites were 3D printed using fused deposition modeling method. In the first set of samples, a filament of pure TPE was immersed in a solution of hCQDs (0.5 mg/mL), then 3D printed, and compared with unmodified TPE filament. The mechanical properties, swelling behavior, hardness, and thermal stability of TPE/hCQDs were compared with the pure TPE printed samples. The production of singlet oxygen was confirmed by the electron paramagnetic resonance method. The antibacterial activity of the samples was tested according to ISO 22196 against Staphylococcus aureus and Escherichia coli after one hour of exposure to blue light, which completely inhibited bacterial growth. Besides, the cytotoxicity of samples was evaluated by MTT assay, and no significant effect of the materials on cell viability was observed. 3D printed materials with antibacterial activity represent a perspective for the future, especially in the field of personalized medicine, as well as in products for other industries.",
journal = "Polymer Bulletin",
title = "Antibacterial activity of 3D printed thermoplastic elastomers doped with carbon quantum dots for biomedical applications",
doi = "10.1007/s00289-024-05339-1"
}

Shaalan, M., Vykydalová, A., Švajdlenková, H., Kroneková, Z., Marković, Z. M., Kováčová, M.,& Špitálský, Z.. (2024). Antibacterial activity of 3D printed thermoplastic elastomers doped with carbon quantum dots for biomedical applications. in Polymer Bulletin.
https://doi.org/10.1007/s00289-024-05339-1

Shaalan M, Vykydalová A, Švajdlenková H, Kroneková Z, Marković ZM, Kováčová M, Špitálský Z. Antibacterial activity of 3D printed thermoplastic elastomers doped with carbon quantum dots for biomedical applications. in Polymer Bulletin. 2024;.
doi:10.1007/s00289-024-05339-1 .

Shaalan, Mohamed, Vykydalová, Anna, Švajdlenková, Helena, Kroneková, Zuzana, Marković, Zoran M., Kováčová, Mária, Špitálský, Zdenko, "Antibacterial activity of 3D printed thermoplastic elastomers doped with carbon quantum dots for biomedical applications" in Polymer Bulletin (2024),
https://doi.org/10.1007/s00289-024-05339-1 . .

TY  - JOUR
AU  - Kováčová, Mária
AU  - Kleinová, Angela
AU  - Vajďák, Ján
AU  - Humpolíček, Petr
AU  - Kubát, Pavel
AU  - Bodík, Michal
AU  - Marković, Zoran M.
AU  - Špitálský, Zdenko
PY  - 2020
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/9637
AB  - Here we present a new effective antibacterial material suitable for a coating, e.g., surface treatment of textiles, which is also time and financially undemanding. The most important role is played by hydrophobic carbon quantum dots, as a new type of photosensitizer, produced by carbonization of different carbon precursors, which are incorporated by swelling from solution into various polymer matrices in the form of thin films, in particular polyurethanes, which are currently commercially used for industrial surface treatment of textiles. The role of hydrophobic carbon quantum dots is to work as photosensitizers upon irradiation and produce reactive oxygen species, namely singlet oxygen, which is already known as the most effective radical for elimination different kinds of bacteria on the surface or in close proximity to such modified material. Therefore, we have mainly studied the effect of hydrophobic carbon quantum dots on Staphylococcus aureus and the cytotoxicity tests, which are essential for the safe handling of such material. Also, the production of singlet oxygen by several methods (electron paramagnetic spectroscopy, time-resolved near-infrared spectroscopy), surface structures (atomic force microscopy and contact angle measurement), and the effect of radiation on polymer matrices were studied. The prepared material is easily modulated by end-user requirements.
T2  - Journal of Photochemistry and Photobiology B: Biology
T1  - Photodynamic-active smart biocompatible material for an antibacterial surface coating
VL  - 211
SP  - 112012
DO  - 10.1016/j.jphotobiol.2020.112012
ER  - 

@article{
author = "Kováčová, Mária and Kleinová, Angela and Vajďák, Ján and Humpolíček, Petr and Kubát, Pavel and Bodík, Michal and Marković, Zoran M. and Špitálský, Zdenko",
year = "2020",
abstract = "Here we present a new effective antibacterial material suitable for a coating, e.g., surface treatment of textiles, which is also time and financially undemanding. The most important role is played by hydrophobic carbon quantum dots, as a new type of photosensitizer, produced by carbonization of different carbon precursors, which are incorporated by swelling from solution into various polymer matrices in the form of thin films, in particular polyurethanes, which are currently commercially used for industrial surface treatment of textiles. The role of hydrophobic carbon quantum dots is to work as photosensitizers upon irradiation and produce reactive oxygen species, namely singlet oxygen, which is already known as the most effective radical for elimination different kinds of bacteria on the surface or in close proximity to such modified material. Therefore, we have mainly studied the effect of hydrophobic carbon quantum dots on Staphylococcus aureus and the cytotoxicity tests, which are essential for the safe handling of such material. Also, the production of singlet oxygen by several methods (electron paramagnetic spectroscopy, time-resolved near-infrared spectroscopy), surface structures (atomic force microscopy and contact angle measurement), and the effect of radiation on polymer matrices were studied. The prepared material is easily modulated by end-user requirements.",
journal = "Journal of Photochemistry and Photobiology B: Biology",
title = "Photodynamic-active smart biocompatible material for an antibacterial surface coating",
volume = "211",
pages = "112012",
doi = "10.1016/j.jphotobiol.2020.112012"
}

Kováčová, M., Kleinová, A., Vajďák, J., Humpolíček, P., Kubát, P., Bodík, M., Marković, Z. M.,& Špitálský, Z.. (2020). Photodynamic-active smart biocompatible material for an antibacterial surface coating. in Journal of Photochemistry and Photobiology B: Biology, 211, 112012.
https://doi.org/10.1016/j.jphotobiol.2020.112012

Kováčová M, Kleinová A, Vajďák J, Humpolíček P, Kubát P, Bodík M, Marković ZM, Špitálský Z. Photodynamic-active smart biocompatible material for an antibacterial surface coating. in Journal of Photochemistry and Photobiology B: Biology. 2020;211:112012.
doi:10.1016/j.jphotobiol.2020.112012 .

Kováčová, Mária, Kleinová, Angela, Vajďák, Ján, Humpolíček, Petr, Kubát, Pavel, Bodík, Michal, Marković, Zoran M., Špitálský, Zdenko, "Photodynamic-active smart biocompatible material for an antibacterial surface coating" in Journal of Photochemistry and Photobiology B: Biology, 211 (2020):112012,
https://doi.org/10.1016/j.jphotobiol.2020.112012 . .