Petrović, Đorđe

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Authority KeyName Variants
orcid::0000-0002-1083-0265
  • Petrović, Đorđe (17)
  • Petrović, Đorđe Ž. (1)
Projects
Physics and Chemistry with Ion Beams Synthesis, processing and characterization of nanostructured materials for application in the field of energy, mechanical engineering, environmental protection and biomedicine
Synthesis, modeling, physicochemical and biological properties of organic compounds and related metal complexes COST Action [CA16217, ENIUS]
Ministry of Education, Science and Technological Development, Republic of Serbia, Grant no. 451-03-68/2020-14/200017 (University of Belgrade, Institute of Nuclear Sciences 'Vinča', Belgrade-Vinča) Ministry of Education, Science and Technological Development, Republic of Serbia, Grant no. 451-03-68/2020-14/200133 (Univeristy of Niš, Faculty of Technology, Leskovac)
Advanced technologies for monitoring and environmental protection from chemical pollutants and radiation burden Magnetic and radionuclide labeled nanostructured materials for medical applications
Implementation and evaluation of a new molecular method for a quick detection of a mecA gene directly in swabs originated from humans, animals and their environment Implementation of new technical, technological and environmental solutions in the mining and metallurgical operations RBB and RBM
Ministry of Education and Sciences of the Republic of Serbia Ministry of Education, Science and technological development of the Republic of Serbia
Ministry of Education, Science and Technological Development of the Republic of Serbia [451-03-2/2020-14/20-0302002] Talented Young Scientist Program of the Ministry of Science and Technology of China
“The Belt and Road Initiative” program [18230742300] VEGA [2/0051/20]

Author's Bibliography

Bactericidal and antioxidant bacterial cellulose hydrogels doped with chitosan as potential urinary tract infection biomedical agent

Zmejkoski, Danica; Marković, Zoran M.; Zdravković, Nemanja M.; Trišić, Dijana; Budimir, Milica; Kuzman, Sanja; Kozyrovska, Natalia O.; Orlovska, Iryna V.; Bugárová, Nikol; Petrović, Đorđe; Kováčová, Mária; Kleinová, Angela; Špitalský, Zdeno; Pavlović, Vladimir B.; Todorović-Marković, Biljana

(2021)

TY  - JOUR
AU  - Zmejkoski, Danica
AU  - Marković, Zoran M.
AU  - Zdravković, Nemanja M.
AU  - Trišić, Dijana
AU  - Budimir, Milica
AU  - Kuzman, Sanja
AU  - Kozyrovska, Natalia O.
AU  - Orlovska, Iryna V.
AU  - Bugárová, Nikol
AU  - Petrović, Đorđe
AU  - Kováčová, Mária
AU  - Kleinová, Angela
AU  - Špitalský, Zdeno
AU  - Pavlović, Vladimir B.
AU  - Todorović-Marković, Biljana
PY  - 2021
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/9143
AB  - Therapy of bacterial urinary tract infections (UTIs) and catheter associated urinary tract infections (CAUTIs) is still a great challenge because of the resistance of bacteria to nowadays used antibiotics and encrustation of catheters. Bacterial cellulose (BC) as a biocompatible material with a high porosity allows incorporation of different materials in its three dimensional network structure. In this work a low molecular weight chitosan (Chi) polymer is incorporated in BC with different concentrations. Different characterization techniques are used to investigate structural and optical properties of these composites. Radical scavenging activity test shows moderate antioxidant activity of these biocompatible composites whereasin vitrorelease test shows that 13.3% of chitosan is released after 72 h. Antibacterial testing of BC-Chi composites conducted on Gram-positive and Gram-negative bacteria causing UTIs and CAUTIs (Escherichia coli,Pseudomonas aeruginosa,Klebsiella pneumoniae) and encrustation (Proteus mirabilis) show bactericidal effect. The morphology analysis of bacteria after the application of BC-Chi shows that they are flattened with a rough surface, with a tendency to agglomerate and with decreased length and width. All obtained results show that BC-Chi composites might be considered as potential biomedical agents in treatment of UTIs and CAUTIs and as a urinary catheter coating in encrustation prevention.
T2  - RSC Advances
T1  - Bactericidal and antioxidant bacterial cellulose hydrogels doped with chitosan as potential urinary tract infection biomedical agent
VL  - 11
IS  - 15
SP  - 8559
EP  - 8568
DO  - 10.1039/D0RA10782D
ER  - 
@article{
author = "Zmejkoski, Danica and Marković, Zoran M. and Zdravković, Nemanja M. and Trišić, Dijana and Budimir, Milica and Kuzman, Sanja and Kozyrovska, Natalia O. and Orlovska, Iryna V. and Bugárová, Nikol and Petrović, Đorđe and Kováčová, Mária and Kleinová, Angela and Špitalský, Zdeno and Pavlović, Vladimir B. and Todorović-Marković, Biljana",
year = "2021",
abstract = "Therapy of bacterial urinary tract infections (UTIs) and catheter associated urinary tract infections (CAUTIs) is still a great challenge because of the resistance of bacteria to nowadays used antibiotics and encrustation of catheters. Bacterial cellulose (BC) as a biocompatible material with a high porosity allows incorporation of different materials in its three dimensional network structure. In this work a low molecular weight chitosan (Chi) polymer is incorporated in BC with different concentrations. Different characterization techniques are used to investigate structural and optical properties of these composites. Radical scavenging activity test shows moderate antioxidant activity of these biocompatible composites whereasin vitrorelease test shows that 13.3% of chitosan is released after 72 h. Antibacterial testing of BC-Chi composites conducted on Gram-positive and Gram-negative bacteria causing UTIs and CAUTIs (Escherichia coli,Pseudomonas aeruginosa,Klebsiella pneumoniae) and encrustation (Proteus mirabilis) show bactericidal effect. The morphology analysis of bacteria after the application of BC-Chi shows that they are flattened with a rough surface, with a tendency to agglomerate and with decreased length and width. All obtained results show that BC-Chi composites might be considered as potential biomedical agents in treatment of UTIs and CAUTIs and as a urinary catheter coating in encrustation prevention.",
journal = "RSC Advances",
title = "Bactericidal and antioxidant bacterial cellulose hydrogels doped with chitosan as potential urinary tract infection biomedical agent",
volume = "11",
number = "15",
pages = "8559-8568",
doi = "10.1039/D0RA10782D"
}
Zmejkoski, D., Marković, Z. M., Zdravković, N. M., Trišić, D., Budimir, M., Kuzman, S., Kozyrovska, N. O., Orlovska, I. V., Bugárová, N., Petrović, Đ., Kováčová, M., Kleinová, A., Špitalský, Z., Pavlović, V. B.,& Todorović-Marković, B.. (2021). Bactericidal and antioxidant bacterial cellulose hydrogels doped with chitosan as potential urinary tract infection biomedical agent. in RSC Advances, 11(15), 8559-8568.
https://doi.org/10.1039/D0RA10782D
Zmejkoski D, Marković ZM, Zdravković NM, Trišić D, Budimir M, Kuzman S, Kozyrovska NO, Orlovska IV, Bugárová N, Petrović Đ, Kováčová M, Kleinová A, Špitalský Z, Pavlović VB, Todorović-Marković B. Bactericidal and antioxidant bacterial cellulose hydrogels doped with chitosan as potential urinary tract infection biomedical agent. in RSC Advances. 2021;11(15):8559-8568.
doi:10.1039/D0RA10782D .
Zmejkoski, Danica, Marković, Zoran M., Zdravković, Nemanja M., Trišić, Dijana, Budimir, Milica, Kuzman, Sanja, Kozyrovska, Natalia O., Orlovska, Iryna V., Bugárová, Nikol, Petrović, Đorđe, Kováčová, Mária, Kleinová, Angela, Špitalský, Zdeno, Pavlović, Vladimir B., Todorović-Marković, Biljana, "Bactericidal and antioxidant bacterial cellulose hydrogels doped with chitosan as potential urinary tract infection biomedical agent" in RSC Advances, 11, no. 15 (2021):8559-8568,
https://doi.org/10.1039/D0RA10782D . .
2
2
2

Laser desorption/ionization time-of-flight mass spectrometry of yttrium(III) chloride

Veljković, Filip M.; Radović, Ivana M.; Toprek, Dragan; Petrović, Đorđe; Stoiljković, Milovan; Mitić, Vojislav V.; Veličković, Suzana

(2021)

TY  - JOUR
AU  - Veljković, Filip M.
AU  - Radović, Ivana M.
AU  - Toprek, Dragan
AU  - Petrović, Đorđe
AU  - Stoiljković, Milovan
AU  - Mitić, Vojislav V.
AU  - Veličković, Suzana
PY  - 2021
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10084
AB  - Due to the increased use of yttrium in agriculture and industry, there is a growing interest in the impact of yttrium on the environment and human health. Developing novel procedures to detect and quantify species of yttrium represents an important task. In this work, we apply laser desorption/ionization-mass spectrometry (LDI-MS) to detect cluster ions of the solution of yttrium(III) chloride (YCl3) at different pH values. The density functional theory (DFT) calculations were used to reveal the energetically most favored structures of the anions and cations chosen from the LDI-MS results. Examination of the positive and negative mode LDI mass spectra of YCl3 showed the presence of the heterogeneous mononuclear and polynuclear clusters, such as [YCl(OH) (H2O)3]++, [Y2(H2O)]++, [Y4H2(H2O)4]++, and [Y5O4H3]++ (at pH 2 and 5) and [Y2Cl2(H2O)2]−−, [Y2O5(HCl)(OH)]−−, and [Y3OH3(OH)2(H2O)]−− (at pH 2, 5, and 10). The variation in the pH solution of YCl3 slightly affects the LDI mass spectrum of these yttrium clusters. It has only been noticed that the [Y4H2(H2O)4]++ cluster ions were not detected at pH 10. These results can become a guide in the detection of yttrium chloride by LDI-MS in real samples in different fields (ecological, food, and human).
T2  - Modern Physics Letters B
T1  - Laser desorption/ionization time-of-flight mass spectrometry of yttrium(III) chloride
VL  - 35
IS  - 35
SP  - 2150454
DO  - 10.1142/S0217984921504546
ER  - 
@article{
author = "Veljković, Filip M. and Radović, Ivana M. and Toprek, Dragan and Petrović, Đorđe and Stoiljković, Milovan and Mitić, Vojislav V. and Veličković, Suzana",
year = "2021",
abstract = "Due to the increased use of yttrium in agriculture and industry, there is a growing interest in the impact of yttrium on the environment and human health. Developing novel procedures to detect and quantify species of yttrium represents an important task. In this work, we apply laser desorption/ionization-mass spectrometry (LDI-MS) to detect cluster ions of the solution of yttrium(III) chloride (YCl3) at different pH values. The density functional theory (DFT) calculations were used to reveal the energetically most favored structures of the anions and cations chosen from the LDI-MS results. Examination of the positive and negative mode LDI mass spectra of YCl3 showed the presence of the heterogeneous mononuclear and polynuclear clusters, such as [YCl(OH) (H2O)3]++, [Y2(H2O)]++, [Y4H2(H2O)4]++, and [Y5O4H3]++ (at pH 2 and 5) and [Y2Cl2(H2O)2]−−, [Y2O5(HCl)(OH)]−−, and [Y3OH3(OH)2(H2O)]−− (at pH 2, 5, and 10). The variation in the pH solution of YCl3 slightly affects the LDI mass spectrum of these yttrium clusters. It has only been noticed that the [Y4H2(H2O)4]++ cluster ions were not detected at pH 10. These results can become a guide in the detection of yttrium chloride by LDI-MS in real samples in different fields (ecological, food, and human).",
journal = "Modern Physics Letters B",
title = "Laser desorption/ionization time-of-flight mass spectrometry of yttrium(III) chloride",
volume = "35",
number = "35",
pages = "2150454",
doi = "10.1142/S0217984921504546"
}
Veljković, F. M., Radović, I. M., Toprek, D., Petrović, Đ., Stoiljković, M., Mitić, V. V.,& Veličković, S.. (2021). Laser desorption/ionization time-of-flight mass spectrometry of yttrium(III) chloride. in Modern Physics Letters B, 35(35), 2150454.
https://doi.org/10.1142/S0217984921504546
Veljković FM, Radović IM, Toprek D, Petrović Đ, Stoiljković M, Mitić VV, Veličković S. Laser desorption/ionization time-of-flight mass spectrometry of yttrium(III) chloride. in Modern Physics Letters B. 2021;35(35):2150454.
doi:10.1142/S0217984921504546 .
Veljković, Filip M., Radović, Ivana M., Toprek, Dragan, Petrović, Đorđe, Stoiljković, Milovan, Mitić, Vojislav V., Veličković, Suzana, "Laser desorption/ionization time-of-flight mass spectrometry of yttrium(III) chloride" in Modern Physics Letters B, 35, no. 35 (2021):2150454,
https://doi.org/10.1142/S0217984921504546 . .

Waste tire carbon in synergetic interaction with spent gamma radioactive source for efficient radiocatalytic degradation of organic dye

Matović, Ljiljana; Vujasin, Radojka; Kumrić, Ksenija; Devečerski, Aleksandar; Wu, Yi-nan ; Kabtamu, Daniel M.; Mirković, Marija D.; Omerašević, Mia; Petrović, Đorđe

(2021)

TY  - JOUR
AU  - Matović, Ljiljana
AU  - Vujasin, Radojka
AU  - Kumrić, Ksenija
AU  - Devečerski, Aleksandar
AU  - Wu, Yi-nan 
AU  - Kabtamu, Daniel M.
AU  - Mirković, Marija D.
AU  - Omerašević, Mia
AU  - Petrović, Đorđe
PY  - 2021
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/9791
AB  - Enhanced degradation of organic dye was achieved using two different kinds of waste materials: waste tire granules and spent sealed radioactive sources. Waste tire granules were used as raw material for the production of waste tire char (WTC), which was further utilized as an adsorbent matrix for synergetic adsorption/irradiation degradation of organic dye. The spent radioactive sources were radiographic sealed sources that originate from the industry which generate the high energy radiation. Methylene Blue (MB) was used as an organic model compound. Synthesized WTC has turbostratic structure, irregular shaped particles and developed mesoporous surface. Complete degradation of 0.02 dm3 of 100 mg dm−3 MB solution, having WTC dose of 1.25 g dm−3, was achieved with delivered doze of only 60 Gy. The applied doses were 100 times smaller than those presented in the literature. Degradation pathway was determined: OH radicals that originate from radiolysis of water and from the surface of WTC played the crucial role in the radiocatalytic degradation of MB. Breakage of the aromatic ring of MB appeared by the scission of the double C‒S+˭C bond as a result of the attack of OH species on adsorbed and electronically reorganized MB molecule. © 2020 Elsevier B.V.
T2  - Journal of Hazardous Materials
T1  - Waste tire carbon in synergetic interaction with spent gamma radioactive source for efficient radiocatalytic degradation of organic dye
VL  - 408
DO  - 10.1016/j.jhazmat.2020.124922
ER  - 
@article{
author = "Matović, Ljiljana and Vujasin, Radojka and Kumrić, Ksenija and Devečerski, Aleksandar and Wu, Yi-nan  and Kabtamu, Daniel M. and Mirković, Marija D. and Omerašević, Mia and Petrović, Đorđe",
year = "2021",
abstract = "Enhanced degradation of organic dye was achieved using two different kinds of waste materials: waste tire granules and spent sealed radioactive sources. Waste tire granules were used as raw material for the production of waste tire char (WTC), which was further utilized as an adsorbent matrix for synergetic adsorption/irradiation degradation of organic dye. The spent radioactive sources were radiographic sealed sources that originate from the industry which generate the high energy radiation. Methylene Blue (MB) was used as an organic model compound. Synthesized WTC has turbostratic structure, irregular shaped particles and developed mesoporous surface. Complete degradation of 0.02 dm3 of 100 mg dm−3 MB solution, having WTC dose of 1.25 g dm−3, was achieved with delivered doze of only 60 Gy. The applied doses were 100 times smaller than those presented in the literature. Degradation pathway was determined: OH radicals that originate from radiolysis of water and from the surface of WTC played the crucial role in the radiocatalytic degradation of MB. Breakage of the aromatic ring of MB appeared by the scission of the double C‒S+˭C bond as a result of the attack of OH species on adsorbed and electronically reorganized MB molecule. © 2020 Elsevier B.V.",
journal = "Journal of Hazardous Materials",
title = "Waste tire carbon in synergetic interaction with spent gamma radioactive source for efficient radiocatalytic degradation of organic dye",
volume = "408",
doi = "10.1016/j.jhazmat.2020.124922"
}
Matović, L., Vujasin, R., Kumrić, K., Devečerski, A., Wu, Y., Kabtamu, D. M., Mirković, M. D., Omerašević, M.,& Petrović, Đ.. (2021). Waste tire carbon in synergetic interaction with spent gamma radioactive source for efficient radiocatalytic degradation of organic dye. in Journal of Hazardous Materials, 408.
https://doi.org/10.1016/j.jhazmat.2020.124922
Matović L, Vujasin R, Kumrić K, Devečerski A, Wu Y, Kabtamu DM, Mirković MD, Omerašević M, Petrović Đ. Waste tire carbon in synergetic interaction with spent gamma radioactive source for efficient radiocatalytic degradation of organic dye. in Journal of Hazardous Materials. 2021;408.
doi:10.1016/j.jhazmat.2020.124922 .
Matović, Ljiljana, Vujasin, Radojka, Kumrić, Ksenija, Devečerski, Aleksandar, Wu, Yi-nan , Kabtamu, Daniel M., Mirković, Marija D., Omerašević, Mia, Petrović, Đorđe, "Waste tire carbon in synergetic interaction with spent gamma radioactive source for efficient radiocatalytic degradation of organic dye" in Journal of Hazardous Materials, 408 (2021),
https://doi.org/10.1016/j.jhazmat.2020.124922 . .
1
1

Intelligent Poly(N-Isopropylmethacrylamide) Hydrogels: Synthesis, Structure Characterization, Stimuli-Responsive Swelling Properties, and Their Radiation Decomposition

Ilić-Stojanović, Snežana; Urošević, Maja; Nikolić, Ljubiša; Petrović, Đorđe; Stanojević, Jelena; Najman, Stevo; Nikolić, Vesna

(2020)

TY  - JOUR
AU  - Ilić-Stojanović, Snežana
AU  - Urošević, Maja
AU  - Nikolić, Ljubiša
AU  - Petrović, Đorđe
AU  - Stanojević, Jelena
AU  - Najman, Stevo
AU  - Nikolić, Vesna
PY  - 2020
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/9033
AB  - Poly(N-isopropylmethacrylamide) (p(NiPMAm)) is one of the lesser known homopolymers that has significant potential for designing new “intelligent” materials. The aims of this work were the synthesis a series of cross-linked p(NiPMAm) hydrogels by the free radical polymerization method and the application of gamma-ray radiation for additional cross-linking. The synthesized p(NiPMAm) hydrogels were structurally characterized by Fourier transform infrared spectroscopy (FTIR) and scanning electron microscopy (SEM). The amount of unreacted monomers was analyzed using high pressure liquid chromatography (HPLC) to evaluate conversion of monomers into polymers. The swelling behavior was monitored in dependence of pH and temperature changes. The previous aim of gamma-ray radiation was the further the cross-linkage of the obtained hydrogel sample in the gelatinous, paste-like state, but the gamma-ray radiation caused decomposition. After absorbing irradiation doses, they transformed into the liquid phase. The results obtained by the gel permeation chromatography (GPC) method indicated that only oligomers and monomers were present in the irradiated liquid material, without molecules with a higher average molar mass, i.e., that the decomposition of the hydrogels occurred. Additionally, the irradiated liquid material was analyzed using the static headspace gas chromatography mass spectrometry (HSS-GC/MS) and gas chromatography/flame ionization detection (HSS-GC/FID) methods. The presence of unchanged initiator molecule and a dominant amount of four new molecules that were different from homopolymers and the reactant (monomer and cross-linker) were determined.
T2  - Polymers
T1  - Intelligent Poly(N-Isopropylmethacrylamide) Hydrogels: Synthesis, Structure Characterization, Stimuli-Responsive Swelling Properties, and Their Radiation Decomposition
VL  - 12
IS  - 5
SP  - 1112
DO  - 10.3390/polym12051112
ER  - 
@article{
author = "Ilić-Stojanović, Snežana and Urošević, Maja and Nikolić, Ljubiša and Petrović, Đorđe and Stanojević, Jelena and Najman, Stevo and Nikolić, Vesna",
year = "2020",
abstract = "Poly(N-isopropylmethacrylamide) (p(NiPMAm)) is one of the lesser known homopolymers that has significant potential for designing new “intelligent” materials. The aims of this work were the synthesis a series of cross-linked p(NiPMAm) hydrogels by the free radical polymerization method and the application of gamma-ray radiation for additional cross-linking. The synthesized p(NiPMAm) hydrogels were structurally characterized by Fourier transform infrared spectroscopy (FTIR) and scanning electron microscopy (SEM). The amount of unreacted monomers was analyzed using high pressure liquid chromatography (HPLC) to evaluate conversion of monomers into polymers. The swelling behavior was monitored in dependence of pH and temperature changes. The previous aim of gamma-ray radiation was the further the cross-linkage of the obtained hydrogel sample in the gelatinous, paste-like state, but the gamma-ray radiation caused decomposition. After absorbing irradiation doses, they transformed into the liquid phase. The results obtained by the gel permeation chromatography (GPC) method indicated that only oligomers and monomers were present in the irradiated liquid material, without molecules with a higher average molar mass, i.e., that the decomposition of the hydrogels occurred. Additionally, the irradiated liquid material was analyzed using the static headspace gas chromatography mass spectrometry (HSS-GC/MS) and gas chromatography/flame ionization detection (HSS-GC/FID) methods. The presence of unchanged initiator molecule and a dominant amount of four new molecules that were different from homopolymers and the reactant (monomer and cross-linker) were determined.",
journal = "Polymers",
title = "Intelligent Poly(N-Isopropylmethacrylamide) Hydrogels: Synthesis, Structure Characterization, Stimuli-Responsive Swelling Properties, and Their Radiation Decomposition",
volume = "12",
number = "5",
pages = "1112",
doi = "10.3390/polym12051112"
}
Ilić-Stojanović, S., Urošević, M., Nikolić, L., Petrović, Đ., Stanojević, J., Najman, S.,& Nikolić, V.. (2020). Intelligent Poly(N-Isopropylmethacrylamide) Hydrogels: Synthesis, Structure Characterization, Stimuli-Responsive Swelling Properties, and Their Radiation Decomposition. in Polymers, 12(5), 1112.
https://doi.org/10.3390/polym12051112
Ilić-Stojanović S, Urošević M, Nikolić L, Petrović Đ, Stanojević J, Najman S, Nikolić V. Intelligent Poly(N-Isopropylmethacrylamide) Hydrogels: Synthesis, Structure Characterization, Stimuli-Responsive Swelling Properties, and Their Radiation Decomposition. in Polymers. 2020;12(5):1112.
doi:10.3390/polym12051112 .
Ilić-Stojanović, Snežana, Urošević, Maja, Nikolić, Ljubiša, Petrović, Đorđe, Stanojević, Jelena, Najman, Stevo, Nikolić, Vesna, "Intelligent Poly(N-Isopropylmethacrylamide) Hydrogels: Synthesis, Structure Characterization, Stimuli-Responsive Swelling Properties, and Their Radiation Decomposition" in Polymers, 12, no. 5 (2020):1112,
https://doi.org/10.3390/polym12051112 . .
2
1
1

Coconut Shell Activated Carbon as Solid-Phase Extraction Adsorbent for Preconcentration of Selected Pesticides from Water Samples

Kumrić, Ksenija; Vujasin, Radojka; Egerić, Marija; Petrović, Đorđe; Devečerski, Aleksandar; Matović, Ljiljana

(2019)

TY  - JOUR
AU  - Kumrić, Ksenija
AU  - Vujasin, Radojka
AU  - Egerić, Marija
AU  - Petrović, Đorđe
AU  - Devečerski, Aleksandar
AU  - Matović, Ljiljana
PY  - 2019
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/8678
AB  - Solid-phase extraction (SPE) on activated carbon derived from coconut shell (CSAC) for the preconcentration of four varying polarity pesticides (imidacloprid, acetamiprid, simazine, and linuron) prior to their determination using high performance liquid chromatography with diode array detector (HPLC-DAD) was investigated. The characteristics of the CSAC were analyzed through X-ray diffraction (XRD), scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FT-IR), and Brunauer-Emmett-Teller (BET) method. The effects of the solution pH, eluent type, eluent volume, and flow rate were investigated for optimization of the presented procedure. The adsorption was achieved quantitatively on the CSAC column in the pH range of 2.0–7.0, and then the retained pesticides were eluted with dichloromethane. The detection limit was found to be 0.025–0.039 μg L−1, depending on the pesticide. The proposed SPE-CSAC method was used to determine selected pesticides in tap water samples. The recoveries ranged from 58.2 to 105.3%, with low relative standard deviations. The obtained results indicated that the CSAC could be efficiently used as a low cost alternative to commercially available SPE adsorbents for the determination of the varying polarity pesticides in environmental water samples at trace levels. © 2019, Springer Nature Switzerland AG.
T2  - Water, Air, & Soil Pollution
T1  - Coconut Shell Activated Carbon as Solid-Phase Extraction Adsorbent for Preconcentration of Selected Pesticides from Water Samples
VL  - 230
IS  - 12
SP  - 302
DO  - 10.1007/s11270-019-4359-7
ER  - 
@article{
author = "Kumrić, Ksenija and Vujasin, Radojka and Egerić, Marija and Petrović, Đorđe and Devečerski, Aleksandar and Matović, Ljiljana",
year = "2019",
abstract = "Solid-phase extraction (SPE) on activated carbon derived from coconut shell (CSAC) for the preconcentration of four varying polarity pesticides (imidacloprid, acetamiprid, simazine, and linuron) prior to their determination using high performance liquid chromatography with diode array detector (HPLC-DAD) was investigated. The characteristics of the CSAC were analyzed through X-ray diffraction (XRD), scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FT-IR), and Brunauer-Emmett-Teller (BET) method. The effects of the solution pH, eluent type, eluent volume, and flow rate were investigated for optimization of the presented procedure. The adsorption was achieved quantitatively on the CSAC column in the pH range of 2.0–7.0, and then the retained pesticides were eluted with dichloromethane. The detection limit was found to be 0.025–0.039 μg L−1, depending on the pesticide. The proposed SPE-CSAC method was used to determine selected pesticides in tap water samples. The recoveries ranged from 58.2 to 105.3%, with low relative standard deviations. The obtained results indicated that the CSAC could be efficiently used as a low cost alternative to commercially available SPE adsorbents for the determination of the varying polarity pesticides in environmental water samples at trace levels. © 2019, Springer Nature Switzerland AG.",
journal = "Water, Air, & Soil Pollution",
title = "Coconut Shell Activated Carbon as Solid-Phase Extraction Adsorbent for Preconcentration of Selected Pesticides from Water Samples",
volume = "230",
number = "12",
pages = "302",
doi = "10.1007/s11270-019-4359-7"
}
Kumrić, K., Vujasin, R., Egerić, M., Petrović, Đ., Devečerski, A.,& Matović, L.. (2019). Coconut Shell Activated Carbon as Solid-Phase Extraction Adsorbent for Preconcentration of Selected Pesticides from Water Samples. in Water, Air, & Soil Pollution, 230(12), 302.
https://doi.org/10.1007/s11270-019-4359-7
Kumrić K, Vujasin R, Egerić M, Petrović Đ, Devečerski A, Matović L. Coconut Shell Activated Carbon as Solid-Phase Extraction Adsorbent for Preconcentration of Selected Pesticides from Water Samples. in Water, Air, & Soil Pollution. 2019;230(12):302.
doi:10.1007/s11270-019-4359-7 .
Kumrić, Ksenija, Vujasin, Radojka, Egerić, Marija, Petrović, Đorđe, Devečerski, Aleksandar, Matović, Ljiljana, "Coconut Shell Activated Carbon as Solid-Phase Extraction Adsorbent for Preconcentration of Selected Pesticides from Water Samples" in Water, Air, & Soil Pollution, 230, no. 12 (2019):302,
https://doi.org/10.1007/s11270-019-4359-7 . .
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3

Y-90-labeled of phosphates-coated magnetic nanoparticles as a potential tumor treatment radiopharmaceuticals

Janković, Drina; Radović, Magdalena; Mirković, M; Vukadinović, Aleksandar; Perić, Marko R.; Petrović, Đorđe; Antić, Bratislav; Vranješ-Đurić, Sanja

(2018)

TY  - CONF
AU  - Janković, Drina
AU  - Radović, Magdalena
AU  - Mirković, M
AU  - Vukadinović, Aleksandar
AU  - Perić, Marko R.
AU  - Petrović, Đorđe
AU  - Antić, Bratislav
AU  - Vranješ-Đurić, Sanja
PY  - 2018
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/8067
C3  - European Journal of Nuclear Medicine and Molecular Imaging
T1  - Y-90-labeled of phosphates-coated magnetic nanoparticles as a potential tumor treatment radiopharmaceuticals
VL  - 45
IS  - Supp. 1
SP  - S649
ER  - 
@conference{
author = "Janković, Drina and Radović, Magdalena and Mirković, M and Vukadinović, Aleksandar and Perić, Marko R. and Petrović, Đorđe and Antić, Bratislav and Vranješ-Đurić, Sanja",
year = "2018",
journal = "European Journal of Nuclear Medicine and Molecular Imaging",
title = "Y-90-labeled of phosphates-coated magnetic nanoparticles as a potential tumor treatment radiopharmaceuticals",
volume = "45",
number = "Supp. 1",
pages = "S649"
}
Janković, D., Radović, M., Mirković, M., Vukadinović, A., Perić, M. R., Petrović, Đ., Antić, B.,& Vranješ-Đurić, S.. (2018). Y-90-labeled of phosphates-coated magnetic nanoparticles as a potential tumor treatment radiopharmaceuticals. in European Journal of Nuclear Medicine and Molecular Imaging, 45(Supp. 1), S649.
Janković D, Radović M, Mirković M, Vukadinović A, Perić MR, Petrović Đ, Antić B, Vranješ-Đurić S. Y-90-labeled of phosphates-coated magnetic nanoparticles as a potential tumor treatment radiopharmaceuticals. in European Journal of Nuclear Medicine and Molecular Imaging. 2018;45(Supp. 1):S649..
Janković, Drina, Radović, Magdalena, Mirković, M, Vukadinović, Aleksandar, Perić, Marko R., Petrović, Đorđe, Antić, Bratislav, Vranješ-Đurić, Sanja, "Y-90-labeled of phosphates-coated magnetic nanoparticles as a potential tumor treatment radiopharmaceuticals" in European Journal of Nuclear Medicine and Molecular Imaging, 45, no. Supp. 1 (2018):S649.
1

Surfactant modification and adsorption properties of clinoptilolite for the removal of pertechnetate from aqueous solutions

Milicevic, Sonja; Matović, Ljiljana; Petrović, Đorđe; Aukic, Andelka; Milosevic, Vladan; Dokic, Divna; Kumrić, Ksenija

(2016)

TY  - JOUR
AU  - Milicevic, Sonja
AU  - Matović, Ljiljana
AU  - Petrović, Đorđe
AU  - Aukic, Andelka
AU  - Milosevic, Vladan
AU  - Dokic, Divna
AU  - Kumrić, Ksenija
PY  - 2016
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/1270
AB  - Natural clinoptilolite modified with a cationic surfactant stearyldimethylbenzylammonium chloride (SDBAC) was used as an adsorbent for the removal of pertechnetate from aqueous solutions. Adsorption studies were performed in a batch system. The effects of various experimental parameters (amount of surfactant loading, contact time, solution pH, competing anions) on the removal efficiency of TcO4 (-) were investigated. SDBAC-clinoptilolite with organo-bilayer was successfully used to remove TcO4 (-) from aqueous solutions in the pH range of 5.0-8.0. ReO4 (-) as an analogue of TcO4 (-) was used to model the isotherms. Adsorption capacity of the SDBAC-clinoptilolite and the mechanism of ReO4 (-) (TcO4 (-)) sorption were also determined.
T2  - Journal of Radioanalytical and Nuclear Chemistry
T1  - Surfactant modification and adsorption properties of clinoptilolite for the removal of pertechnetate from aqueous solutions
VL  - 310
IS  - 2
SP  - 805
EP  - 815
DO  - 10.1007/s10967-016-4850-1
ER  - 
@article{
author = "Milicevic, Sonja and Matović, Ljiljana and Petrović, Đorđe and Aukic, Andelka and Milosevic, Vladan and Dokic, Divna and Kumrić, Ksenija",
year = "2016",
abstract = "Natural clinoptilolite modified with a cationic surfactant stearyldimethylbenzylammonium chloride (SDBAC) was used as an adsorbent for the removal of pertechnetate from aqueous solutions. Adsorption studies were performed in a batch system. The effects of various experimental parameters (amount of surfactant loading, contact time, solution pH, competing anions) on the removal efficiency of TcO4 (-) were investigated. SDBAC-clinoptilolite with organo-bilayer was successfully used to remove TcO4 (-) from aqueous solutions in the pH range of 5.0-8.0. ReO4 (-) as an analogue of TcO4 (-) was used to model the isotherms. Adsorption capacity of the SDBAC-clinoptilolite and the mechanism of ReO4 (-) (TcO4 (-)) sorption were also determined.",
journal = "Journal of Radioanalytical and Nuclear Chemistry",
title = "Surfactant modification and adsorption properties of clinoptilolite for the removal of pertechnetate from aqueous solutions",
volume = "310",
number = "2",
pages = "805-815",
doi = "10.1007/s10967-016-4850-1"
}
Milicevic, S., Matović, L., Petrović, Đ., Aukic, A., Milosevic, V., Dokic, D.,& Kumrić, K.. (2016). Surfactant modification and adsorption properties of clinoptilolite for the removal of pertechnetate from aqueous solutions. in Journal of Radioanalytical and Nuclear Chemistry, 310(2), 805-815.
https://doi.org/10.1007/s10967-016-4850-1
Milicevic S, Matović L, Petrović Đ, Aukic A, Milosevic V, Dokic D, Kumrić K. Surfactant modification and adsorption properties of clinoptilolite for the removal of pertechnetate from aqueous solutions. in Journal of Radioanalytical and Nuclear Chemistry. 2016;310(2):805-815.
doi:10.1007/s10967-016-4850-1 .
Milicevic, Sonja, Matović, Ljiljana, Petrović, Đorđe, Aukic, Andelka, Milosevic, Vladan, Dokic, Divna, Kumrić, Ksenija, "Surfactant modification and adsorption properties of clinoptilolite for the removal of pertechnetate from aqueous solutions" in Journal of Radioanalytical and Nuclear Chemistry, 310, no. 2 (2016):805-815,
https://doi.org/10.1007/s10967-016-4850-1 . .
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Study of the hydrolytic properties of the trivalent Y-ion in chloride medium

Petrović, Đorđe; Jakovljević, Ivan; Joksović, Ljubinka G.; Szecsenyi, Katalin Meszaros; Durdevic, Predrag

(2016)

TY  - JOUR
AU  - Petrović, Đorđe
AU  - Jakovljević, Ivan
AU  - Joksović, Ljubinka G.
AU  - Szecsenyi, Katalin Meszaros
AU  - Durdevic, Predrag
PY  - 2016
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/276
AB  - Hydrolysis reactions of YCl3 aqueous solutions were studied by potentiometric titrations at 310 K in the pH range ca.3-9 and total Y3+ ion concentration range 0.5-10.0 mmol/dm(3). The experimental data were evaluated with the aid of the Hyperquad2006 suite of programs, which indicated the formation of the following hydrolytic complexes (log conc. overall stability constants beta(p,q) defined as beta(p,q) = M-p(OH)(q)[H](q)/[M](p)), Y(OH)(2+) (-7.71(2)); Y(OH)(2)(+) (-16.42(2)); Y(OH)(3) (-26.01(3)); Y-2(OH)(2)(4+) (-14.23(4)); Y-3(OH)(5)(2+) (-34.20 (4)); Y-4(OH)(6)(2+) (-37.10(5)). The hydrolysis of the Y3+ ion was also monitored by electrospray ionization ion-trap mass spectrometry (ESI-MS) in the pH range 2.63-7.10. The influence of the sample cone voltage on the product distribution was significant, indicating the contribution of ion source fragmentation reactions. The optimal cone voltage was set to 70 V for cationic and 100 V for anionic spectra. The cationic and anionic ESI mass spectra of the Y3+ solutions produced strong evidence for the presence of a variety of monomeric and polymeric hydrolytic complexes. The Cl- ion appeared to be a strong competitor to the OH- ion for the oxo-yttrium core. The hydrolytic precipitation reactions with NaOH or urea as precipitating agents were studied. The obtained precipitates were characterized by the potentiometric technique, elemental analysis, thermal analysis (TG-DSC), infrared spectroscopy, X-ray diffractions and the SEM technique. Hydrothermal synthesis of the precipitate in an autoclave at T= 420 K and P = 10 bar with NaOH as the precipitating agent produced a crystalline precipitate in the form of hexagonal needles (P6(3)/m space group). At atmospheric pressure only an amorphous precipitate was produced with both precipitating agents. The concentration solubility product K-so* of Y(OH)(3) was evaluated from the potentiometric titrations curves and logK(so)* = -22.85(4). The synthesized precipitate with NaOH as a precipitating agent had a composition of Y(OH)(3)center dot 2H(2)O, while the amorphous precipitate obtained with urea had a composition of Y-2(OH)(2)(CO3)(2)center dot 3H(2)O. (C) 2015 Elsevier Ltd. All rights reserved.
T2  - Polyhedron
T1  - Study of the hydrolytic properties of the trivalent Y-ion in chloride medium
VL  - 105
SP  - 1
EP  - 11
DO  - 10.1016/j.poly.2015.11.047
ER  - 
@article{
author = "Petrović, Đorđe and Jakovljević, Ivan and Joksović, Ljubinka G. and Szecsenyi, Katalin Meszaros and Durdevic, Predrag",
year = "2016",
abstract = "Hydrolysis reactions of YCl3 aqueous solutions were studied by potentiometric titrations at 310 K in the pH range ca.3-9 and total Y3+ ion concentration range 0.5-10.0 mmol/dm(3). The experimental data were evaluated with the aid of the Hyperquad2006 suite of programs, which indicated the formation of the following hydrolytic complexes (log conc. overall stability constants beta(p,q) defined as beta(p,q) = M-p(OH)(q)[H](q)/[M](p)), Y(OH)(2+) (-7.71(2)); Y(OH)(2)(+) (-16.42(2)); Y(OH)(3) (-26.01(3)); Y-2(OH)(2)(4+) (-14.23(4)); Y-3(OH)(5)(2+) (-34.20 (4)); Y-4(OH)(6)(2+) (-37.10(5)). The hydrolysis of the Y3+ ion was also monitored by electrospray ionization ion-trap mass spectrometry (ESI-MS) in the pH range 2.63-7.10. The influence of the sample cone voltage on the product distribution was significant, indicating the contribution of ion source fragmentation reactions. The optimal cone voltage was set to 70 V for cationic and 100 V for anionic spectra. The cationic and anionic ESI mass spectra of the Y3+ solutions produced strong evidence for the presence of a variety of monomeric and polymeric hydrolytic complexes. The Cl- ion appeared to be a strong competitor to the OH- ion for the oxo-yttrium core. The hydrolytic precipitation reactions with NaOH or urea as precipitating agents were studied. The obtained precipitates were characterized by the potentiometric technique, elemental analysis, thermal analysis (TG-DSC), infrared spectroscopy, X-ray diffractions and the SEM technique. Hydrothermal synthesis of the precipitate in an autoclave at T= 420 K and P = 10 bar with NaOH as the precipitating agent produced a crystalline precipitate in the form of hexagonal needles (P6(3)/m space group). At atmospheric pressure only an amorphous precipitate was produced with both precipitating agents. The concentration solubility product K-so* of Y(OH)(3) was evaluated from the potentiometric titrations curves and logK(so)* = -22.85(4). The synthesized precipitate with NaOH as a precipitating agent had a composition of Y(OH)(3)center dot 2H(2)O, while the amorphous precipitate obtained with urea had a composition of Y-2(OH)(2)(CO3)(2)center dot 3H(2)O. (C) 2015 Elsevier Ltd. All rights reserved.",
journal = "Polyhedron",
title = "Study of the hydrolytic properties of the trivalent Y-ion in chloride medium",
volume = "105",
pages = "1-11",
doi = "10.1016/j.poly.2015.11.047"
}
Petrović, Đ., Jakovljević, I., Joksović, L. G., Szecsenyi, K. M.,& Durdevic, P.. (2016). Study of the hydrolytic properties of the trivalent Y-ion in chloride medium. in Polyhedron, 105, 1-11.
https://doi.org/10.1016/j.poly.2015.11.047
Petrović Đ, Jakovljević I, Joksović LG, Szecsenyi KM, Durdevic P. Study of the hydrolytic properties of the trivalent Y-ion in chloride medium. in Polyhedron. 2016;105:1-11.
doi:10.1016/j.poly.2015.11.047 .
Petrović, Đorđe, Jakovljević, Ivan, Joksović, Ljubinka G., Szecsenyi, Katalin Meszaros, Durdevic, Predrag, "Study of the hydrolytic properties of the trivalent Y-ion in chloride medium" in Polyhedron, 105 (2016):1-11,
https://doi.org/10.1016/j.poly.2015.11.047 . .
1
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2

Biospecijacija itrijum(III)-jona i njegovih radiofarmaceutika

Petrović, Đorđe Ž.

(Универзитет у Крагујевцу, Природно-математички факултет, 2016)

TY  - THES
AU  - Petrović, Đorđe Ž.
PY  - 2016
UR  - http://eteze.kg.ac.rs/application/showtheses?thesesId=3002
UR  - https://fedorakg.kg.ac.rs/fedora/get/o:673/bdef:Content/download
UR  - http://nardus.mpn.gov.rs/123456789/5616
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/7278
AB  - Radiofarmaceutici bazirani na različitim molekulima obeleženimitrijumom-90, se koriste pri tretmanu neoperativnih vrsta tumora, kao i u radijacionoj sinovektomiji. Veliko interesovanje za korišćenje 90Y u terapeutske svrhe potiče zbog njegovih nuklearnih karakteristika (t1/2=64,1, Eβ,max= 2,3 MeV,bez emisije  zračenja). Dostupnost 90Y sa vrlo niskom radiohemijskom kontaminacijom je od suštinske važnosti u terapeutskoj primeni.Postojanje dugoživućeg pretka 90Sr sa vremenom poluživota od 28,9 godina i kratkoživućeg potomka 90Y nam omogućavaju formiranje generatorskog sistema. Iako postoje nekoliko vrsta generatora, prema literaturnim podacima, elektrohemijski generatori i generatori zasnovani na tečnim membranama imaju najveću perspektivu.Membranska ekstrakcija se takođe naziva i pertrakcija i bazirana je natrofaznom sistemu sa organskom fazom (tečna membrana) koja se nalazi između dve vodene faze i predstavlja alternativnu metodu klasičnoj tečno-tečnoj ekstrakciji. Prema literaturnim podacima, koristi se za razdvajanje širokog opsega rastvorenih supstanci uključujući biološke molekule, metalne jone, organske zagađivače i radionuklide.Elektrohemijska metoda je predložena kao rešenje pri separaciji 86Y od 86Sr i dobijanje 86Y koji služi pri pozitronsko emisionoj tomografiji (PET).Literaturni podaci pokazuju da elektrohemijska separacija predstavlja dobro rešenje jer omogućava veliku efikasnost uz minimalnu  kontaminaciju okolnog prostora.Radiofarmaceutici koji se koriste u terapiji su u hemijskom smislukompleksna jedinjenja u kojima se kao centralni joni javljaju radioaktivni izotopi metala sa  ili  raspadom, dok su ligandi organski molekuli koji su sposobni da stvaraju helate. Ovi molekuli pored toga što su helatori za radiometal imaju i ulogu da se vežu za biomolekul. Zbog toga se i nazivaju bifunkcionalni helatori. Najpoznatiji i do sada najviše korišćeni bifunkcionalni helatori u radiohemiji itrijuma su: 1,4,7,10-tetraazociklododekan-1,4,7,10-tetraacetatna kiselina (DOTA) i dietilentriamin-pentasirćetna kiselina (DTPA).Klinička ispitivanja pokazuju da je eliminacija radiofarmaceutika izorganizma uglavnom brza i potpuna. Smatra se i da je metabolička transformacija radiofarmaceutika uglavnom minimalna. Međutim, u određenim uslovima može doći do ispoljavanja toksičnih efekata itrijuma i to kada je eliminacija radiofarmaceutika sprečena ili produžena i kada dolazi do disocijacije radiofarmaceutika. Tada se itrijum raspodeljuje između različitih liganada krvne plazme, prvenstveno, fosfata, karbonata i hidroksida. Biospecijacijazavisi ne samo od prirode radiofarmaceutika već i od prisustva drugihpotencijalnih liganada u krvnoj plazmi kao i neorganskih jona. Premaliteraturnim podacima specijacija i biodistribucija Y(III)-jona u humanoj plazmi, su proučavane u prisustvu ograničenog broja liganada, tako da postoji potreba da se proširi broj liganada koji se koristi prilikom ispitivanja. Tako je, pored već navedenih bifunkcionalnih helatora, u istraživanje uključen i ciprofloksacin, koji predstavlja četvrtu generaciju hinolona aktivnih na Gram-pozitivne bakterije i atipične patogene koji su uzročnici infekcija respiratornog trakta. Kako se Y(III)-jon u organizam unosi kompleksiran ligandima DTPA i DOTA koji se koriste u nuklearnoj medicini potrebno je i njih uključiti prilikom proračuna raspodele ovog jona u humanoj plazmi.Smatra se da je Y(III)-jon u organizmu uglavnom prisutan u obliku svojih hidrolitičkih kompleksa. Odavde može da se zaključi da interakcija Y(III)-jona i liganada u biološkim uslovima predstavlja interakcije sa hidrolitičkim kompleksima itrijuma.U prethodnih trideset godina, hidroliza itrijuma je proučavana povremeno pomoću različitih metoda ali nikada nije sistematski istraženo forimiranje hidrolitičkim kompleksa itrijuma. U literaturi mogu da se nađu pojedinačna ispitivanja hidrolize itrijuma ili termogravimetrijska analiza taloga itrijum-hidroksida, ali ne i podaci o ispitivanju na masenom spektrometru.Potenciometrijske metode daju najkorisnije informacije o vrstamahidrolitičkih komleksa, kao i o njihovim konstantama stabilnosti. Masena spektrometrija nam takođe može dati dosta podataka o vrstama hidrolitičkih kompleksa koje mogu da se jave u rastvorima.Stabilnost komleksa itrijuma sa DTPA, DOTA i ciprofloksacinom se možeodređivati potenciometrijski i masenospektrometrijskim merenjima.Cilj istraživanja ove doktorske teze predstavlja iznalaženje hidrolitičkih vrsta i određivanje njihovih konstati u sistemima koji su kompatibilni sa humanom krvnom plazmom (vodeni rastovor 0,15 mol dm-3 NaCl na 310,0 K). Takođe određivanje konstanti stabilnosti itrijuma sa DTPA i ciprofloksacinom omogućava dobijanje podataka koji se koriste pri specijaciji i određivanju biodistribucije Y(III)-jona u humanoj plazmi.Dobijeni rezultati mogu biti korisni kao osnova za razvoj i razumevanje novih antitumorski aktivnih kompleksa, kao i za razumevanje interakcija između kompleksa prelaznih metala i molekula od biološkog značaja.
AB  - The subject of this dissertation was biospeciation of Y(III) ion in human blood plasma. To this end characterization of complexation equilibria of Y3+ with DTPA, DOTA and ciprofloxacine and production of yttrium-90 from Sr/Y generator was made.Hydrolysis and complexation of yttrium were investigated using potentiometricmesurenment with glass electrode in 0.15 mol dm-3 NaCl ionic medium, at 310.0 ± 0.5 К. In addition, data of the hydrolysis of yttrium (III) ion and complexation of yttrium (III) ion with DTPA and DOTA were obtained by ESI MS technique. Morphologies of various kinds of yttrium-hydroxide precipitates were examined using a scanning electron microscopy. Precipitates were also analyzed by thermogravimetric analysis (TGA) and infrared spectroscopy using KBr pill technique. Computer modeling May model was used for the determination of yttrium species in human plasma and certain dominant yttrium complexes with small molecules. The second part of the Thesis relate to the separation of90Y from 90Sr with high radiochemical yield and purity, that can be used for labelling organic molecules (DTPA and DOTA) which are used in nuclear medicine.The obtained results can be sumarized as follows: The stability constants of hydrolitic complexes (log β,.q) were: Y(OH)2+ (log β1,-1 = -7.71 ± 0.05), Y(OH)2+ (log β1,-2 = -16.42 ± 0.03), Y(OH)3 (log β1,-3 = -26.01± 0.03),Y2(OH)2 4+(log β2,-2 = -14.23± 0.05), Y3(OH)54+ (log β3,-5 = -34.20 ± 0.07) иY4(OH)66+(log β4,-6 = -37.10 ± 0.08). Hydrolytic species determined by potentiometric method were confirmed by ESIMS method also. Hydrolytic species containing tetramer ions with high charges were: [Y4(OH)4(H2O)2]8+, [Y4(OH)2Cl2]8+ и [Y4(OH)3ClH2O]8+. The hydrolytic precipitation reactions with NaOH or urea as precipitating agents were studied. The obtained precipitates were characterized by the X-ray diffraction, the SEM technique, thermal analysis (TG-DSC) and infrared spectroscopy. Powder X-ray diffraction (XRD) characterization indicated that the product, which was obtained by a hydrothermal method, could be indexed to a pure hexagonal phase of Y(OH)3, [space group: P63/m], and no peak shifts and other impurity phases appear. Scanning electron microscopy (SEM) observations indicated that the product was composed of chaotic spread needle particles. These needles were relatively uniform in size length of 8 μm and up to half a micron thick. The thermogravimetric and infrared analysis of the precipitate indicated a adsorbed and crystal water which were lost at higher temperatures. Transformation of the yttrium- hydroxide in yttrium-oxide was made at 873 K. Stability constants of protonated DTPA (log βp.q) were determined bypotentiometric method: HDTPA (logβ1,1 = 9.95±0.02), H2DTPA (logβ1,2 =18.68±0.01), H3DTPA (logβ1,3 = 23.30±0.03), H4DTPA (logβ1,4 = 26.55±0.02) иH5DTPA (logβ1,5 = 29.51±0.03).  Investigation of complexation in the system Y(III)-DTPA indicated that protonated and non-protonated complexes exist in solution with stability constants (log βp.q,r):[YDTPA]2-(logβ1,1,0 = 22.51±0.03) и [YHDTPA]-(logβ1,1,1 = 24.41±0.05). The speciation of Y(III)-ions in human plasma has been studied by computersimulation using the program HySS2006. May’s model that included 43 ligands (26 amino acids, 7 inorganic ligands, 8 carboxylic acids, 2 protein) and 9 metal ions which are dominant in human blood plasma (Ca2+, Mg2+, Zn2+, Pb2+, Mn2+, Fe2+,Fe3+, Zn 2+ and Cu2+) was used. Stability constants of metal ions with ligads were taken from literature. Concentration of yttrium in the model was 1 × 10-9 mol dm-3, which corresponds to the concentration that is used in radionuclide therapy. In normal serum Y(III) ion is bound to citrates (YCit = 47.63 % and YCit2 = 2.98 %)and carbonates (Y(CO3)2 = 32.46 % and Y(CO3) = 10.60 %). Amount ofyttrium bound to oxalate is very small (YOxa = 1.57 %). Increasing the totalconcentrations of yttrium up to 1× 10–8 mol dm–3and 1× 10–7 mol dm–3 complexes of yttrium with citrates are still dominant species with unchanged share of 85.64% and 98.98%. Further increasing concentrations of Y(III) ions from 1× 10–6 mol dm-3 up to 1× 10-3 mol dm-3, leads to appearance of insoluble species of yttriumcarbonates Y2(CO3)3(s)). Separation of yttrium(III) from strontium(II) with 15 % (v/v) di(2-ethylhexyl) phosphoric acid (DEHPA) in dodecane was carried out in a hollow fiber supported liquid membrane (SLM) extraction system operated under closed-loop recirculation of the donor and acceptor phase. The effect of different flow rate of donor and acceptor in the extraction of Sr(II) and Y(III) ions were investigated. Optimal conditions were found (QA = 0.8 cm3 min -1and QD = 4.7 cm3 min-1) when the yield of Y(III) in the acceptor phase reached 60 % after 360 min with a molar ratio of Y(III) to Sr(II) in the acceptor of 250:1, as compared to1:25 in the donor phase. Preparation of 90Y in ,,home-made" 90Sr/90Y generators with defined chemical and radiochemical purity was carried out electrochemicaly in two cycle electrolysis procedure. Quality control of the resulting yttrium is determined by "BARC" technique and subsequently used for labelling DOTATATE. Control of the labeledproduct was performed by HPLC using SepPak C-18 columns.
PB  - Универзитет у Крагујевцу, Природно-математички факултет
T2  - Универзитет у Крагујевцу
T1  - Biospecijacija itrijum(III)-jona i njegovih radiofarmaceutika
UR  - https://hdl.handle.net/21.15107/rcub_nardus_5616
ER  - 
@phdthesis{
author = "Petrović, Đorđe Ž.",
year = "2016",
abstract = "Radiofarmaceutici bazirani na različitim molekulima obeleženimitrijumom-90, se koriste pri tretmanu neoperativnih vrsta tumora, kao i u radijacionoj sinovektomiji. Veliko interesovanje za korišćenje 90Y u terapeutske svrhe potiče zbog njegovih nuklearnih karakteristika (t1/2=64,1, Eβ,max= 2,3 MeV,bez emisije  zračenja). Dostupnost 90Y sa vrlo niskom radiohemijskom kontaminacijom je od suštinske važnosti u terapeutskoj primeni.Postojanje dugoživućeg pretka 90Sr sa vremenom poluživota od 28,9 godina i kratkoživućeg potomka 90Y nam omogućavaju formiranje generatorskog sistema. Iako postoje nekoliko vrsta generatora, prema literaturnim podacima, elektrohemijski generatori i generatori zasnovani na tečnim membranama imaju najveću perspektivu.Membranska ekstrakcija se takođe naziva i pertrakcija i bazirana je natrofaznom sistemu sa organskom fazom (tečna membrana) koja se nalazi između dve vodene faze i predstavlja alternativnu metodu klasičnoj tečno-tečnoj ekstrakciji. Prema literaturnim podacima, koristi se za razdvajanje širokog opsega rastvorenih supstanci uključujući biološke molekule, metalne jone, organske zagađivače i radionuklide.Elektrohemijska metoda je predložena kao rešenje pri separaciji 86Y od 86Sr i dobijanje 86Y koji služi pri pozitronsko emisionoj tomografiji (PET).Literaturni podaci pokazuju da elektrohemijska separacija predstavlja dobro rešenje jer omogućava veliku efikasnost uz minimalnu  kontaminaciju okolnog prostora.Radiofarmaceutici koji se koriste u terapiji su u hemijskom smislukompleksna jedinjenja u kojima se kao centralni joni javljaju radioaktivni izotopi metala sa  ili  raspadom, dok su ligandi organski molekuli koji su sposobni da stvaraju helate. Ovi molekuli pored toga što su helatori za radiometal imaju i ulogu da se vežu za biomolekul. Zbog toga se i nazivaju bifunkcionalni helatori. Najpoznatiji i do sada najviše korišćeni bifunkcionalni helatori u radiohemiji itrijuma su: 1,4,7,10-tetraazociklododekan-1,4,7,10-tetraacetatna kiselina (DOTA) i dietilentriamin-pentasirćetna kiselina (DTPA).Klinička ispitivanja pokazuju da je eliminacija radiofarmaceutika izorganizma uglavnom brza i potpuna. Smatra se i da je metabolička transformacija radiofarmaceutika uglavnom minimalna. Međutim, u određenim uslovima može doći do ispoljavanja toksičnih efekata itrijuma i to kada je eliminacija radiofarmaceutika sprečena ili produžena i kada dolazi do disocijacije radiofarmaceutika. Tada se itrijum raspodeljuje između različitih liganada krvne plazme, prvenstveno, fosfata, karbonata i hidroksida. Biospecijacijazavisi ne samo od prirode radiofarmaceutika već i od prisustva drugihpotencijalnih liganada u krvnoj plazmi kao i neorganskih jona. Premaliteraturnim podacima specijacija i biodistribucija Y(III)-jona u humanoj plazmi, su proučavane u prisustvu ograničenog broja liganada, tako da postoji potreba da se proširi broj liganada koji se koristi prilikom ispitivanja. Tako je, pored već navedenih bifunkcionalnih helatora, u istraživanje uključen i ciprofloksacin, koji predstavlja četvrtu generaciju hinolona aktivnih na Gram-pozitivne bakterije i atipične patogene koji su uzročnici infekcija respiratornog trakta. Kako se Y(III)-jon u organizam unosi kompleksiran ligandima DTPA i DOTA koji se koriste u nuklearnoj medicini potrebno je i njih uključiti prilikom proračuna raspodele ovog jona u humanoj plazmi.Smatra se da je Y(III)-jon u organizmu uglavnom prisutan u obliku svojih hidrolitičkih kompleksa. Odavde može da se zaključi da interakcija Y(III)-jona i liganada u biološkim uslovima predstavlja interakcije sa hidrolitičkim kompleksima itrijuma.U prethodnih trideset godina, hidroliza itrijuma je proučavana povremeno pomoću različitih metoda ali nikada nije sistematski istraženo forimiranje hidrolitičkim kompleksa itrijuma. U literaturi mogu da se nađu pojedinačna ispitivanja hidrolize itrijuma ili termogravimetrijska analiza taloga itrijum-hidroksida, ali ne i podaci o ispitivanju na masenom spektrometru.Potenciometrijske metode daju najkorisnije informacije o vrstamahidrolitičkih komleksa, kao i o njihovim konstantama stabilnosti. Masena spektrometrija nam takođe može dati dosta podataka o vrstama hidrolitičkih kompleksa koje mogu da se jave u rastvorima.Stabilnost komleksa itrijuma sa DTPA, DOTA i ciprofloksacinom se možeodređivati potenciometrijski i masenospektrometrijskim merenjima.Cilj istraživanja ove doktorske teze predstavlja iznalaženje hidrolitičkih vrsta i određivanje njihovih konstati u sistemima koji su kompatibilni sa humanom krvnom plazmom (vodeni rastovor 0,15 mol dm-3 NaCl na 310,0 K). Takođe određivanje konstanti stabilnosti itrijuma sa DTPA i ciprofloksacinom omogućava dobijanje podataka koji se koriste pri specijaciji i određivanju biodistribucije Y(III)-jona u humanoj plazmi.Dobijeni rezultati mogu biti korisni kao osnova za razvoj i razumevanje novih antitumorski aktivnih kompleksa, kao i za razumevanje interakcija između kompleksa prelaznih metala i molekula od biološkog značaja., The subject of this dissertation was biospeciation of Y(III) ion in human blood plasma. To this end characterization of complexation equilibria of Y3+ with DTPA, DOTA and ciprofloxacine and production of yttrium-90 from Sr/Y generator was made.Hydrolysis and complexation of yttrium were investigated using potentiometricmesurenment with glass electrode in 0.15 mol dm-3 NaCl ionic medium, at 310.0 ± 0.5 К. In addition, data of the hydrolysis of yttrium (III) ion and complexation of yttrium (III) ion with DTPA and DOTA were obtained by ESI MS technique. Morphologies of various kinds of yttrium-hydroxide precipitates were examined using a scanning electron microscopy. Precipitates were also analyzed by thermogravimetric analysis (TGA) and infrared spectroscopy using KBr pill technique. Computer modeling May model was used for the determination of yttrium species in human plasma and certain dominant yttrium complexes with small molecules. The second part of the Thesis relate to the separation of90Y from 90Sr with high radiochemical yield and purity, that can be used for labelling organic molecules (DTPA and DOTA) which are used in nuclear medicine.The obtained results can be sumarized as follows: The stability constants of hydrolitic complexes (log β,.q) were: Y(OH)2+ (log β1,-1 = -7.71 ± 0.05), Y(OH)2+ (log β1,-2 = -16.42 ± 0.03), Y(OH)3 (log β1,-3 = -26.01± 0.03),Y2(OH)2 4+(log β2,-2 = -14.23± 0.05), Y3(OH)54+ (log β3,-5 = -34.20 ± 0.07) иY4(OH)66+(log β4,-6 = -37.10 ± 0.08). Hydrolytic species determined by potentiometric method were confirmed by ESIMS method also. Hydrolytic species containing tetramer ions with high charges were: [Y4(OH)4(H2O)2]8+, [Y4(OH)2Cl2]8+ и [Y4(OH)3ClH2O]8+. The hydrolytic precipitation reactions with NaOH or urea as precipitating agents were studied. The obtained precipitates were characterized by the X-ray diffraction, the SEM technique, thermal analysis (TG-DSC) and infrared spectroscopy. Powder X-ray diffraction (XRD) characterization indicated that the product, which was obtained by a hydrothermal method, could be indexed to a pure hexagonal phase of Y(OH)3, [space group: P63/m], and no peak shifts and other impurity phases appear. Scanning electron microscopy (SEM) observations indicated that the product was composed of chaotic spread needle particles. These needles were relatively uniform in size length of 8 μm and up to half a micron thick. The thermogravimetric and infrared analysis of the precipitate indicated a adsorbed and crystal water which were lost at higher temperatures. Transformation of the yttrium- hydroxide in yttrium-oxide was made at 873 K. Stability constants of protonated DTPA (log βp.q) were determined bypotentiometric method: HDTPA (logβ1,1 = 9.95±0.02), H2DTPA (logβ1,2 =18.68±0.01), H3DTPA (logβ1,3 = 23.30±0.03), H4DTPA (logβ1,4 = 26.55±0.02) иH5DTPA (logβ1,5 = 29.51±0.03).  Investigation of complexation in the system Y(III)-DTPA indicated that protonated and non-protonated complexes exist in solution with stability constants (log βp.q,r):[YDTPA]2-(logβ1,1,0 = 22.51±0.03) и [YHDTPA]-(logβ1,1,1 = 24.41±0.05). The speciation of Y(III)-ions in human plasma has been studied by computersimulation using the program HySS2006. May’s model that included 43 ligands (26 amino acids, 7 inorganic ligands, 8 carboxylic acids, 2 protein) and 9 metal ions which are dominant in human blood plasma (Ca2+, Mg2+, Zn2+, Pb2+, Mn2+, Fe2+,Fe3+, Zn 2+ and Cu2+) was used. Stability constants of metal ions with ligads were taken from literature. Concentration of yttrium in the model was 1 × 10-9 mol dm-3, which corresponds to the concentration that is used in radionuclide therapy. In normal serum Y(III) ion is bound to citrates (YCit = 47.63 % and YCit2 = 2.98 %)and carbonates (Y(CO3)2 = 32.46 % and Y(CO3) = 10.60 %). Amount ofyttrium bound to oxalate is very small (YOxa = 1.57 %). Increasing the totalconcentrations of yttrium up to 1× 10–8 mol dm–3and 1× 10–7 mol dm–3 complexes of yttrium with citrates are still dominant species with unchanged share of 85.64% and 98.98%. Further increasing concentrations of Y(III) ions from 1× 10–6 mol dm-3 up to 1× 10-3 mol dm-3, leads to appearance of insoluble species of yttriumcarbonates Y2(CO3)3(s)). Separation of yttrium(III) from strontium(II) with 15 % (v/v) di(2-ethylhexyl) phosphoric acid (DEHPA) in dodecane was carried out in a hollow fiber supported liquid membrane (SLM) extraction system operated under closed-loop recirculation of the donor and acceptor phase. The effect of different flow rate of donor and acceptor in the extraction of Sr(II) and Y(III) ions were investigated. Optimal conditions were found (QA = 0.8 cm3 min -1and QD = 4.7 cm3 min-1) when the yield of Y(III) in the acceptor phase reached 60 % after 360 min with a molar ratio of Y(III) to Sr(II) in the acceptor of 250:1, as compared to1:25 in the donor phase. Preparation of 90Y in ,,home-made" 90Sr/90Y generators with defined chemical and radiochemical purity was carried out electrochemicaly in two cycle electrolysis procedure. Quality control of the resulting yttrium is determined by "BARC" technique and subsequently used for labelling DOTATATE. Control of the labeledproduct was performed by HPLC using SepPak C-18 columns.",
publisher = "Универзитет у Крагујевцу, Природно-математички факултет",
journal = "Универзитет у Крагујевцу",
title = "Biospecijacija itrijum(III)-jona i njegovih radiofarmaceutika",
url = "https://hdl.handle.net/21.15107/rcub_nardus_5616"
}
Petrović, Đ. Ž.. (2016). Biospecijacija itrijum(III)-jona i njegovih radiofarmaceutika. in Универзитет у Крагујевцу
Универзитет у Крагујевцу, Природно-математички факултет..
https://hdl.handle.net/21.15107/rcub_nardus_5616
Petrović ĐŽ. Biospecijacija itrijum(III)-jona i njegovih radiofarmaceutika. in Универзитет у Крагујевцу. 2016;.
https://hdl.handle.net/21.15107/rcub_nardus_5616 .
Petrović, Đorđe Ž., "Biospecijacija itrijum(III)-jona i njegovih radiofarmaceutika" in Универзитет у Крагујевцу (2016),
https://hdl.handle.net/21.15107/rcub_nardus_5616 .

Novel Sr-90-Y-90 generator system based on a pertraction through supported liquid membrane in hollow fiber contactor

Petrović, Đorđe; Trtić-Petrović, Tatjana M.; Vladisavljević, Goran T.; Stoiljković, Milovan; Slavković-Beškoski, Latinka J.; Kumrić, Ksenija

(2015)

TY  - JOUR
AU  - Petrović, Đorđe
AU  - Trtić-Petrović, Tatjana M.
AU  - Vladisavljević, Goran T.
AU  - Stoiljković, Milovan
AU  - Slavković-Beškoski, Latinka J.
AU  - Kumrić, Ksenija
PY  - 2015
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/562
AB  - Separation of yttrium(III) from strontium(II) with 15% (v/v) di(2-ethylhexyl)phosphoric acid (DEHPA) in dodecane was carried out in a hollow fiber supported liquid membrane (SLM) extraction system operated under closed-loop recirculation of the donor and acceptor phase. The donor phase was a mixture of 5.7 mmol dm(-3) of Sr(II) and 0.23 mmol dm(-3) of Y(III) in 0.1 mol dm(-3) HCl, the acceptor solution was 3 mol dm(-3) HCl, and the donor to acceptor phase volume ratio was 6.2. At the donor flow rate of 4.7 cm(3) min(-1) and the acceptor flow rate of 0.8 cm(3) min(-1), the yield of Y(III) in the acceptor phase (in the form suitable for radiopharmaceutical preparation) reached 60% after 360 min with a molar ratio of Y(III) to Sr(II) in the acceptor of 250:1, as compared to 1:25 in the donor phase. The yield of Y(III) was 72% at the acceptor flow rate to 1.9 cm3 min(-1), but a breakthrough of Sr(II) through liquid membrane increased from 0.02 to 0.2%. (C) 2015 The Institution a Chemical Engineers. Published by Elsevier B.V. All rights reserved.
T2  - Chemical Engineering Research and Design
T1  - Novel Sr-90-Y-90 generator system based on a pertraction through supported liquid membrane in hollow fiber contactor
VL  - 97
SP  - 57
EP  - 67
DO  - 10.1016/j.cherd.2015.03.015
ER  - 
@article{
author = "Petrović, Đorđe and Trtić-Petrović, Tatjana M. and Vladisavljević, Goran T. and Stoiljković, Milovan and Slavković-Beškoski, Latinka J. and Kumrić, Ksenija",
year = "2015",
abstract = "Separation of yttrium(III) from strontium(II) with 15% (v/v) di(2-ethylhexyl)phosphoric acid (DEHPA) in dodecane was carried out in a hollow fiber supported liquid membrane (SLM) extraction system operated under closed-loop recirculation of the donor and acceptor phase. The donor phase was a mixture of 5.7 mmol dm(-3) of Sr(II) and 0.23 mmol dm(-3) of Y(III) in 0.1 mol dm(-3) HCl, the acceptor solution was 3 mol dm(-3) HCl, and the donor to acceptor phase volume ratio was 6.2. At the donor flow rate of 4.7 cm(3) min(-1) and the acceptor flow rate of 0.8 cm(3) min(-1), the yield of Y(III) in the acceptor phase (in the form suitable for radiopharmaceutical preparation) reached 60% after 360 min with a molar ratio of Y(III) to Sr(II) in the acceptor of 250:1, as compared to 1:25 in the donor phase. The yield of Y(III) was 72% at the acceptor flow rate to 1.9 cm3 min(-1), but a breakthrough of Sr(II) through liquid membrane increased from 0.02 to 0.2%. (C) 2015 The Institution a Chemical Engineers. Published by Elsevier B.V. All rights reserved.",
journal = "Chemical Engineering Research and Design",
title = "Novel Sr-90-Y-90 generator system based on a pertraction through supported liquid membrane in hollow fiber contactor",
volume = "97",
pages = "57-67",
doi = "10.1016/j.cherd.2015.03.015"
}
Petrović, Đ., Trtić-Petrović, T. M., Vladisavljević, G. T., Stoiljković, M., Slavković-Beškoski, L. J.,& Kumrić, K.. (2015). Novel Sr-90-Y-90 generator system based on a pertraction through supported liquid membrane in hollow fiber contactor. in Chemical Engineering Research and Design, 97, 57-67.
https://doi.org/10.1016/j.cherd.2015.03.015
Petrović Đ, Trtić-Petrović TM, Vladisavljević GT, Stoiljković M, Slavković-Beškoski LJ, Kumrić K. Novel Sr-90-Y-90 generator system based on a pertraction through supported liquid membrane in hollow fiber contactor. in Chemical Engineering Research and Design. 2015;97:57-67.
doi:10.1016/j.cherd.2015.03.015 .
Petrović, Đorđe, Trtić-Petrović, Tatjana M., Vladisavljević, Goran T., Stoiljković, Milovan, Slavković-Beškoski, Latinka J., Kumrić, Ksenija, "Novel Sr-90-Y-90 generator system based on a pertraction through supported liquid membrane in hollow fiber contactor" in Chemical Engineering Research and Design, 97 (2015):57-67,
https://doi.org/10.1016/j.cherd.2015.03.015 . .
12
11
12

Complex formation equilibria between aluminum(III), gadolinium(III) and yttrium(III) ions and some fluoroquinolone ligands. Potentiometric and spectroscopic study

Jakovljević, Ivan; Petrović, Đorđe; Joksović, Ljubinka G.; Lazarević, Ivan; Jelikić-Stankov, Milena; Đurđević, Predrag

(Taylor & Francis, 2015)

TY  - JOUR
AU  - Jakovljević, Ivan
AU  - Petrović, Đorđe
AU  - Joksović, Ljubinka G.
AU  - Lazarević, Ivan
AU  - Jelikić-Stankov, Milena
AU  - Đurđević, Predrag
PY  - 2015
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/833
AB  - Complex formation equilibria of aluminum(III), gadolinium(III), and yttrium(III) ions with the fluoroquinolone antibacterials moxifloxacin, ofloxacin, fleroxacin, lomefloxacin, levofloxacin, and ciprofloxacin were studied in aqueous solution by potentiometric and spectroscopic methods. The identity and stability of metal-fluoroquinolone complexes were determined by analyzing potentiometric titration curves (310K, =0.15M NaCl, pH range=2-11, C-L/C-M=1:1 to 3:1, C-M=1.0mM) with the aid of Hyperquad2006 program. The main species formed in the system may be formulated as MpHqLr (p=1, q=-2 to 2, r=1-3, L=fluoroquinolone anion, logarithm of overall stability constant, log (p,q,r)=in the range ca. -10 to 45). The stability of complexes is mostly influenced by metal ion properties (ionization potential, ionic radius) indicating partial ionic character of the coordination bond. The complexes were also characterized by spectroscopic measurements: spectrofluorimetry, H-1-NMR, and ESI-MS. Fluorimetric data were evaluated with the aid of HypSpec2014 and indicated the formation of MLr (r=1-3) complexes with cumulative conditional stability constants significantly lower than the thermodynamic ones. NMR and MS data corroborate potentiometrically determined speciation. Calculated plasma mobilizing capacity of the ligands generally follows the order levofloxacin GT moxifloxacin GT ciprofloxacin at concentration levels of the ligands higher or equal to ca. 10(-4)M.
PB  - Taylor & Francis
T2  - Journal of Coordination Chemistry
T1  - Complex formation equilibria between aluminum(III), gadolinium(III) and yttrium(III) ions and some fluoroquinolone ligands. Potentiometric and spectroscopic study
VL  - 68
IS  - 24
SP  - 4272
EP  - 4295
DO  - 10.1080/00958972.2015.1089535
ER  - 
@article{
author = "Jakovljević, Ivan and Petrović, Đorđe and Joksović, Ljubinka G. and Lazarević, Ivan and Jelikić-Stankov, Milena and Đurđević, Predrag",
year = "2015",
abstract = "Complex formation equilibria of aluminum(III), gadolinium(III), and yttrium(III) ions with the fluoroquinolone antibacterials moxifloxacin, ofloxacin, fleroxacin, lomefloxacin, levofloxacin, and ciprofloxacin were studied in aqueous solution by potentiometric and spectroscopic methods. The identity and stability of metal-fluoroquinolone complexes were determined by analyzing potentiometric titration curves (310K, =0.15M NaCl, pH range=2-11, C-L/C-M=1:1 to 3:1, C-M=1.0mM) with the aid of Hyperquad2006 program. The main species formed in the system may be formulated as MpHqLr (p=1, q=-2 to 2, r=1-3, L=fluoroquinolone anion, logarithm of overall stability constant, log (p,q,r)=in the range ca. -10 to 45). The stability of complexes is mostly influenced by metal ion properties (ionization potential, ionic radius) indicating partial ionic character of the coordination bond. The complexes were also characterized by spectroscopic measurements: spectrofluorimetry, H-1-NMR, and ESI-MS. Fluorimetric data were evaluated with the aid of HypSpec2014 and indicated the formation of MLr (r=1-3) complexes with cumulative conditional stability constants significantly lower than the thermodynamic ones. NMR and MS data corroborate potentiometrically determined speciation. Calculated plasma mobilizing capacity of the ligands generally follows the order levofloxacin GT moxifloxacin GT ciprofloxacin at concentration levels of the ligands higher or equal to ca. 10(-4)M.",
publisher = "Taylor & Francis",
journal = "Journal of Coordination Chemistry",
title = "Complex formation equilibria between aluminum(III), gadolinium(III) and yttrium(III) ions and some fluoroquinolone ligands. Potentiometric and spectroscopic study",
volume = "68",
number = "24",
pages = "4272-4295",
doi = "10.1080/00958972.2015.1089535"
}
Jakovljević, I., Petrović, Đ., Joksović, L. G., Lazarević, I., Jelikić-Stankov, M.,& Đurđević, P.. (2015). Complex formation equilibria between aluminum(III), gadolinium(III) and yttrium(III) ions and some fluoroquinolone ligands. Potentiometric and spectroscopic study. in Journal of Coordination Chemistry
Taylor & Francis., 68(24), 4272-4295.
https://doi.org/10.1080/00958972.2015.1089535
Jakovljević I, Petrović Đ, Joksović LG, Lazarević I, Jelikić-Stankov M, Đurđević P. Complex formation equilibria between aluminum(III), gadolinium(III) and yttrium(III) ions and some fluoroquinolone ligands. Potentiometric and spectroscopic study. in Journal of Coordination Chemistry. 2015;68(24):4272-4295.
doi:10.1080/00958972.2015.1089535 .
Jakovljević, Ivan, Petrović, Đorđe, Joksović, Ljubinka G., Lazarević, Ivan, Jelikić-Stankov, Milena, Đurđević, Predrag, "Complex formation equilibria between aluminum(III), gadolinium(III) and yttrium(III) ions and some fluoroquinolone ligands. Potentiometric and spectroscopic study" in Journal of Coordination Chemistry, 68, no. 24 (2015):4272-4295,
https://doi.org/10.1080/00958972.2015.1089535 . .
4
4
4

Mechanism of sorption of pertechnetate onto ordered mesoporous carbon

Petrović, Đorđe; Đukić, Anđelka B.; Kumrić, Ksenija; Babić, Biljana M.; Momčilović, Milan Z.; Ivanović, Nenad; Matović, Ljiljana

(2014)

TY  - JOUR
AU  - Petrović, Đorđe
AU  - Đukić, Anđelka B.
AU  - Kumrić, Ksenija
AU  - Babić, Biljana M.
AU  - Momčilović, Milan Z.
AU  - Ivanović, Nenad
AU  - Matović, Ljiljana
PY  - 2014
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/126
AB  - Ordered mesoporous carbon (OMC) was used as an adsorbent for the removal of pertechnetate (TcO4 (-)) anion. The maximum uptake (93 %) of TcO4 (-) was obtained after 60 min of contact. The adsorption of TcO4 (-) is almost pH-independent in very wide pH region (from 4.0 to 10.0). Maximum K (d) of 6.6 x 10(3) cm(3) g(-1) was found at pH 2.0. TcO4 (-) interacts with carboxylic functional groups present at the surface of the OMC by displacing the OH- ions with TcO4 (-) via ion exchange mechanism.
T2  - Journal of Radioanalytical and Nuclear Chemistry
T1  - Mechanism of sorption of pertechnetate onto ordered mesoporous carbon
VL  - 302
IS  - 1
SP  - 217
EP  - 224
DO  - 10.1007/s10967-014-3249-0
ER  - 
@article{
author = "Petrović, Đorđe and Đukić, Anđelka B. and Kumrić, Ksenija and Babić, Biljana M. and Momčilović, Milan Z. and Ivanović, Nenad and Matović, Ljiljana",
year = "2014",
abstract = "Ordered mesoporous carbon (OMC) was used as an adsorbent for the removal of pertechnetate (TcO4 (-)) anion. The maximum uptake (93 %) of TcO4 (-) was obtained after 60 min of contact. The adsorption of TcO4 (-) is almost pH-independent in very wide pH region (from 4.0 to 10.0). Maximum K (d) of 6.6 x 10(3) cm(3) g(-1) was found at pH 2.0. TcO4 (-) interacts with carboxylic functional groups present at the surface of the OMC by displacing the OH- ions with TcO4 (-) via ion exchange mechanism.",
journal = "Journal of Radioanalytical and Nuclear Chemistry",
title = "Mechanism of sorption of pertechnetate onto ordered mesoporous carbon",
volume = "302",
number = "1",
pages = "217-224",
doi = "10.1007/s10967-014-3249-0"
}
Petrović, Đ., Đukić, A. B., Kumrić, K., Babić, B. M., Momčilović, M. Z., Ivanović, N.,& Matović, L.. (2014). Mechanism of sorption of pertechnetate onto ordered mesoporous carbon. in Journal of Radioanalytical and Nuclear Chemistry, 302(1), 217-224.
https://doi.org/10.1007/s10967-014-3249-0
Petrović Đ, Đukić AB, Kumrić K, Babić BM, Momčilović MZ, Ivanović N, Matović L. Mechanism of sorption of pertechnetate onto ordered mesoporous carbon. in Journal of Radioanalytical and Nuclear Chemistry. 2014;302(1):217-224.
doi:10.1007/s10967-014-3249-0 .
Petrović, Đorđe, Đukić, Anđelka B., Kumrić, Ksenija, Babić, Biljana M., Momčilović, Milan Z., Ivanović, Nenad, Matović, Ljiljana, "Mechanism of sorption of pertechnetate onto ordered mesoporous carbon" in Journal of Radioanalytical and Nuclear Chemistry, 302, no. 1 (2014):217-224,
https://doi.org/10.1007/s10967-014-3249-0 . .
15
14
14

Separation of yttrium from strontium by hollow fibre supported liquid membrane containing di(2-ethylhexyl)phosphoric acid

Kumrić, Ksenija; Petrović, Đorđe; Vladisavljević, Goran T.; Stoiljković, Milovan; Slavković-Beškoski, Latinka J.

(Society of Physical Chemists of Serbia, 2014)

TY  - CONF
AU  - Kumrić, Ksenija
AU  - Petrović, Đorđe
AU  - Vladisavljević, Goran T.
AU  - Stoiljković, Milovan
AU  - Slavković-Beškoski, Latinka J.
PY  - 2014
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/9253
AB  - Separation of Y(III) from Sr(II) was performed using the hollow fibre
membrane contactor operated in a recirculation mode. The steady-state was
established after ~5 h of operation and the maximum removal of Y(III) from
the donor to the acceptor was achieved at the donor flow rate of 4.7 cm3
min-1. The investigated system showed promising results as a method which
could be potentially applied for the preparation of 90Sr/90Y generator system.
PB  - Society of Physical Chemists of Serbia
C3  - PHYSICAL CHEMISTRY 2014: 12th International Conference on Fundamental and Applied Aspects of Physical Chemistry
T1  - Separation of yttrium from strontium by hollow fibre supported liquid membrane containing di(2-ethylhexyl)phosphoric acid
VL  - L-05-P
ER  - 
@conference{
author = "Kumrić, Ksenija and Petrović, Đorđe and Vladisavljević, Goran T. and Stoiljković, Milovan and Slavković-Beškoski, Latinka J.",
year = "2014",
abstract = "Separation of Y(III) from Sr(II) was performed using the hollow fibre
membrane contactor operated in a recirculation mode. The steady-state was
established after ~5 h of operation and the maximum removal of Y(III) from
the donor to the acceptor was achieved at the donor flow rate of 4.7 cm3
min-1. The investigated system showed promising results as a method which
could be potentially applied for the preparation of 90Sr/90Y generator system.",
publisher = "Society of Physical Chemists of Serbia",
journal = "PHYSICAL CHEMISTRY 2014: 12th International Conference on Fundamental and Applied Aspects of Physical Chemistry",
title = "Separation of yttrium from strontium by hollow fibre supported liquid membrane containing di(2-ethylhexyl)phosphoric acid",
volume = "L-05-P"
}
Kumrić, K., Petrović, Đ., Vladisavljević, G. T., Stoiljković, M.,& Slavković-Beškoski, L. J.. (2014). Separation of yttrium from strontium by hollow fibre supported liquid membrane containing di(2-ethylhexyl)phosphoric acid. in PHYSICAL CHEMISTRY 2014: 12th International Conference on Fundamental and Applied Aspects of Physical Chemistry
Society of Physical Chemists of Serbia., L-05-P.
Kumrić K, Petrović Đ, Vladisavljević GT, Stoiljković M, Slavković-Beškoski LJ. Separation of yttrium from strontium by hollow fibre supported liquid membrane containing di(2-ethylhexyl)phosphoric acid. in PHYSICAL CHEMISTRY 2014: 12th International Conference on Fundamental and Applied Aspects of Physical Chemistry. 2014;L-05-P..
Kumrić, Ksenija, Petrović, Đorđe, Vladisavljević, Goran T., Stoiljković, Milovan, Slavković-Beškoski, Latinka J., "Separation of yttrium from strontium by hollow fibre supported liquid membrane containing di(2-ethylhexyl)phosphoric acid" in PHYSICAL CHEMISTRY 2014: 12th International Conference on Fundamental and Applied Aspects of Physical Chemistry, L-05-P (2014).

Sorption of pertechnetate onto ordered mesoporous carbon

Petrović, Đorđe; Ðukić, Anđelka; Kumrić, Ksenija; Milanović, Igor; Rašković-Lovre, Željka; Matović, Ljiljana

(Society of Physical Chemists of Serbia, 2014)

TY  - CONF
AU  - Petrović, Đorđe
AU  - Ðukić, Anđelka
AU  - Kumrić, Ksenija
AU  - Milanović, Igor
AU  - Rašković-Lovre, Željka
AU  - Matović, Ljiljana
PY  - 2014
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/9255
AB  - Ordered mesoporous carbon (OMC) was used as an adsorbent for the
removal of pertechnetate (TcO4
-) anion. Batch experiments were performed
to study the effects of pH and ionic strength of the solution. The adsorption
of TcO4
- is almost pH-independent in very wide pH region (from 4.0 to
10.0). Maximum distribution coefficient, Kd, was obtained at pH 2.0.
Adsorption of TcO4
- was not affected by the ionic strength changes.
PB  - Society of Physical Chemists of Serbia
C3  - PHYSICAL CHEMISTRY 2014: 12th International Conference on Fundamental and Applied Aspects of Physical Chemistry
T1  - Sorption of pertechnetate onto ordered mesoporous carbon
VL  - L-06-P
ER  - 
@conference{
author = "Petrović, Đorđe and Ðukić, Anđelka and Kumrić, Ksenija and Milanović, Igor and Rašković-Lovre, Željka and Matović, Ljiljana",
year = "2014",
abstract = "Ordered mesoporous carbon (OMC) was used as an adsorbent for the
removal of pertechnetate (TcO4
-) anion. Batch experiments were performed
to study the effects of pH and ionic strength of the solution. The adsorption
of TcO4
- is almost pH-independent in very wide pH region (from 4.0 to
10.0). Maximum distribution coefficient, Kd, was obtained at pH 2.0.
Adsorption of TcO4
- was not affected by the ionic strength changes.",
publisher = "Society of Physical Chemists of Serbia",
journal = "PHYSICAL CHEMISTRY 2014: 12th International Conference on Fundamental and Applied Aspects of Physical Chemistry",
title = "Sorption of pertechnetate onto ordered mesoporous carbon",
volume = "L-06-P"
}
Petrović, Đ., Ðukić, A., Kumrić, K., Milanović, I., Rašković-Lovre, Ž.,& Matović, L.. (2014). Sorption of pertechnetate onto ordered mesoporous carbon. in PHYSICAL CHEMISTRY 2014: 12th International Conference on Fundamental and Applied Aspects of Physical Chemistry
Society of Physical Chemists of Serbia., L-06-P.
Petrović Đ, Ðukić A, Kumrić K, Milanović I, Rašković-Lovre Ž, Matović L. Sorption of pertechnetate onto ordered mesoporous carbon. in PHYSICAL CHEMISTRY 2014: 12th International Conference on Fundamental and Applied Aspects of Physical Chemistry. 2014;L-06-P..
Petrović, Đorđe, Ðukić, Anđelka, Kumrić, Ksenija, Milanović, Igor, Rašković-Lovre, Željka, Matović, Ljiljana, "Sorption of pertechnetate onto ordered mesoporous carbon" in PHYSICAL CHEMISTRY 2014: 12th International Conference on Fundamental and Applied Aspects of Physical Chemistry, L-06-P (2014).

Computer Simulation of Speciation of Trivalent Aluminum, Gadolinium and Yttrium Ions in Human Blood Plasma

Jakovljević, Ivan; Petrović, Đorđe; Joksović, Ljubinka G.; Lazarević, Ivan; Durdevic, Predrag

(2013)

TY  - JOUR
AU  - Jakovljević, Ivan
AU  - Petrović, Đorđe
AU  - Joksović, Ljubinka G.
AU  - Lazarević, Ivan
AU  - Durdevic, Predrag
PY  - 2013
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/5824
AB  - The speciation of Al3+, Gd3+ and Y3+ ions in human plasma has been studied by computer simulation using the program HySS2009. A literature computer model of blood plasma was updated and comprised 9 metals, 43 ligands and over 6100 complexes. To this model critically evaluated data of Al3+, Gd3+ and Y3+ constants with blood plasma ligands have been added. Low molecular mass (LMM) speciation of Al3+ ion strongly depends upon the chosen equilibrium model of the metal - phosphate and metal - citrate systems. The obtained computer simulation of LMM speciation data of Al3+ ion were: AlPO(4)Cit (40.7%), AlPO(4)CitOH (22.9%), AlCitOH (19.2%) and AlPO4(OH) (12.7%) (% of total LMM Al species pool); for Gd3+ ion: GdAspCit (30%) and GdCit(OH)(2) (20%) (% of total [Gd]) and for Y3+ ion: YCit (48%), Y(CO3)(2) (32%) and Y(CO3) (11%) (% of total [Y]). Citrate appears as the important binding and mobilizing ligand for all examined ions, while the dominating species are the ternary ones.
T2  - Acta Chimica Slovenica
T1  - Computer Simulation of Speciation of Trivalent Aluminum, Gadolinium and Yttrium Ions in Human Blood Plasma
VL  - 60
IS  - 4
SP  - 861
EP  - 869
ER  - 
@article{
author = "Jakovljević, Ivan and Petrović, Đorđe and Joksović, Ljubinka G. and Lazarević, Ivan and Durdevic, Predrag",
year = "2013",
abstract = "The speciation of Al3+, Gd3+ and Y3+ ions in human plasma has been studied by computer simulation using the program HySS2009. A literature computer model of blood plasma was updated and comprised 9 metals, 43 ligands and over 6100 complexes. To this model critically evaluated data of Al3+, Gd3+ and Y3+ constants with blood plasma ligands have been added. Low molecular mass (LMM) speciation of Al3+ ion strongly depends upon the chosen equilibrium model of the metal - phosphate and metal - citrate systems. The obtained computer simulation of LMM speciation data of Al3+ ion were: AlPO(4)Cit (40.7%), AlPO(4)CitOH (22.9%), AlCitOH (19.2%) and AlPO4(OH) (12.7%) (% of total LMM Al species pool); for Gd3+ ion: GdAspCit (30%) and GdCit(OH)(2) (20%) (% of total [Gd]) and for Y3+ ion: YCit (48%), Y(CO3)(2) (32%) and Y(CO3) (11%) (% of total [Y]). Citrate appears as the important binding and mobilizing ligand for all examined ions, while the dominating species are the ternary ones.",
journal = "Acta Chimica Slovenica",
title = "Computer Simulation of Speciation of Trivalent Aluminum, Gadolinium and Yttrium Ions in Human Blood Plasma",
volume = "60",
number = "4",
pages = "861-869"
}
Jakovljević, I., Petrović, Đ., Joksović, L. G., Lazarević, I.,& Durdevic, P.. (2013). Computer Simulation of Speciation of Trivalent Aluminum, Gadolinium and Yttrium Ions in Human Blood Plasma. in Acta Chimica Slovenica, 60(4), 861-869.
Jakovljević I, Petrović Đ, Joksović LG, Lazarević I, Durdevic P. Computer Simulation of Speciation of Trivalent Aluminum, Gadolinium and Yttrium Ions in Human Blood Plasma. in Acta Chimica Slovenica. 2013;60(4):861-869..
Jakovljević, Ivan, Petrović, Đorđe, Joksović, Ljubinka G., Lazarević, Ivan, Durdevic, Predrag, "Computer Simulation of Speciation of Trivalent Aluminum, Gadolinium and Yttrium Ions in Human Blood Plasma" in Acta Chimica Slovenica, 60, no. 4 (2013):861-869.
5

99mTc-complex of novel diamine-dioxime ligand

Mirković, Marija D.; Vranješ-Đurić, Sanja; Stanković, Dalibor M.; Petrović, Đorđe; Mijin, Dušan Ž.; Nikolić, Nadežda S.

(Society of Physical Chemists of Serbia, 2012)

TY  - CONF
AU  - Mirković, Marija D.
AU  - Vranješ-Đurić, Sanja
AU  - Stanković, Dalibor M.
AU  - Petrović, Đorđe
AU  - Mijin, Dušan Ž.
AU  - Nikolić, Nadežda S.
PY  - 2012
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/9351
AB  - Novel diamine-dioxime ligand, 4,7-diaza-3,8-diethyldecane-2,9-dione bis oxime
(LH2), derivative of hexamethyl-propylene amine oxime (HMPAO), was
synthesized in order to develop new brain perfusion imaging agent, based on
99mTc(V) complexes. The 99mTc(V)-d,l-HMPAO complex is well-known
radiopharmaceutical for brain imaging. The structures of the synthesized
compound were characterized by UV-Vis, IR, 1
H NMR and 13C NMR. The
procedure for radiolabeling of diamine-dioxime with 99mTc was developed and
radiolabeling yield of the 99mTc-complex was followed by paper and thin-layer
chromatography. The maximum radiolabeling yield was obtained when the
reactions were carried out at pH~9 within 10 min at room temperature (RT).
Biodistribution studies on rats has shown significant uptake of 99mTc-complex
(2.1% ID), 2 min after injection.
PB  - Society of Physical Chemists of Serbia
C3  - Physical chemistry 2012 : 11th international conference on fundamental and applied aspects of physical chemistry
T1  - 99mTc-complex of novel diamine-dioxime ligand
VL  - 2
SP  - 585
EP  - 587
ER  - 
@conference{
author = "Mirković, Marija D. and Vranješ-Đurić, Sanja and Stanković, Dalibor M. and Petrović, Đorđe and Mijin, Dušan Ž. and Nikolić, Nadežda S.",
year = "2012",
abstract = "Novel diamine-dioxime ligand, 4,7-diaza-3,8-diethyldecane-2,9-dione bis oxime
(LH2), derivative of hexamethyl-propylene amine oxime (HMPAO), was
synthesized in order to develop new brain perfusion imaging agent, based on
99mTc(V) complexes. The 99mTc(V)-d,l-HMPAO complex is well-known
radiopharmaceutical for brain imaging. The structures of the synthesized
compound were characterized by UV-Vis, IR, 1
H NMR and 13C NMR. The
procedure for radiolabeling of diamine-dioxime with 99mTc was developed and
radiolabeling yield of the 99mTc-complex was followed by paper and thin-layer
chromatography. The maximum radiolabeling yield was obtained when the
reactions were carried out at pH~9 within 10 min at room temperature (RT).
Biodistribution studies on rats has shown significant uptake of 99mTc-complex
(2.1% ID), 2 min after injection.",
publisher = "Society of Physical Chemists of Serbia",
journal = "Physical chemistry 2012 : 11th international conference on fundamental and applied aspects of physical chemistry",
title = "99mTc-complex of novel diamine-dioxime ligand",
volume = "2",
pages = "585-587"
}
Mirković, M. D., Vranješ-Đurić, S., Stanković, D. M., Petrović, Đ., Mijin, D. Ž.,& Nikolić, N. S.. (2012). 99mTc-complex of novel diamine-dioxime ligand. in Physical chemistry 2012 : 11th international conference on fundamental and applied aspects of physical chemistry
Society of Physical Chemists of Serbia., 2, 585-587.
Mirković MD, Vranješ-Đurić S, Stanković DM, Petrović Đ, Mijin DŽ, Nikolić NS. 99mTc-complex of novel diamine-dioxime ligand. in Physical chemistry 2012 : 11th international conference on fundamental and applied aspects of physical chemistry. 2012;2:585-587..
Mirković, Marija D., Vranješ-Đurić, Sanja, Stanković, Dalibor M., Petrović, Đorđe, Mijin, Dušan Ž., Nikolić, Nadežda S., "99mTc-complex of novel diamine-dioxime ligand" in Physical chemistry 2012 : 11th international conference on fundamental and applied aspects of physical chemistry, 2 (2012):585-587.

Electrochemical Separation of 90-Yttrium in the Electrochemical Sr-90/Y-90 Generator and Its Use for Radiolabelling of Dota-Conjugated Somatostatin Analog [Dota(0), Tyr(3)] Octreotate

Petrović, Đorđe; Nikolić, Nadežda S.; Stanković, Dragana; Đokić, Divna Đ.

(2012)

TY  - JOUR
AU  - Petrović, Đorđe
AU  - Nikolić, Nadežda S.
AU  - Stanković, Dragana
AU  - Đokić, Divna Đ.
PY  - 2012
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/5069
AB  - Radiopharmaceuticals based on Y-90 are widely used in the treatment of malignant deseases. In order to meet the requirements for their future application, a Sr-90/Y-90 generator was developed and 90Y eluted from this locally produced generator was used for the radiolabelling of the DOTA-conjugated somatostatin analog [DOTA(0),Tyr(3)] octreotate and the preparation of [Y-90-DOTA(0),Tyr(3)] octreotate (Y-90-DOTATATE) for peptide receptore radionuclide therapy. Sr-90/Y-90 generator was based on the electrochemical separation of Y-90 from Sr-90 in a two-cycle electrolysis procedure. Three electrode cells were used to perform both electrolyses. In both cycles, working electrodes were kept on constant potential. The pH of the solution was adjusted to 2.7 of the value before the electrolyses. The radionucliclic purity of the Y-90 solution was analysed by ITLC and extraction paper chromatography. The labelling of peptide (100 mu g DOTATATE) with (YCl3)-Y-90 was performed at 95 degrees C for 30 minutes. Radiochemical purity was determined by HPLC and chromatographic separation, using a solid SepPak C-18 column. Results obtained confirmed the efficiency of our electrochemical separation technique and quality control methods for Y-90. The achieved efficiency of the Sr-90/Y-90 generator above 96% of the theoretical value represents a good basis for the further development of this generator. The labelling of the DOTATATE with Y-90 exhibited a high efficiency, too: there was less than 1% of Y-90(3+) in the Y-90-DOTATATE.
T2  - Nuclear technology and radiation protection
T1  - Electrochemical Separation of 90-Yttrium in the Electrochemical Sr-90/Y-90 Generator and Its Use for Radiolabelling of Dota-Conjugated Somatostatin Analog [Dota(0), Tyr(3)] Octreotate
VL  - 27
IS  - 3
SP  - 260
EP  - 268
DO  - 10.2298/NTRP1203260P
ER  - 
@article{
author = "Petrović, Đorđe and Nikolić, Nadežda S. and Stanković, Dragana and Đokić, Divna Đ.",
year = "2012",
abstract = "Radiopharmaceuticals based on Y-90 are widely used in the treatment of malignant deseases. In order to meet the requirements for their future application, a Sr-90/Y-90 generator was developed and 90Y eluted from this locally produced generator was used for the radiolabelling of the DOTA-conjugated somatostatin analog [DOTA(0),Tyr(3)] octreotate and the preparation of [Y-90-DOTA(0),Tyr(3)] octreotate (Y-90-DOTATATE) for peptide receptore radionuclide therapy. Sr-90/Y-90 generator was based on the electrochemical separation of Y-90 from Sr-90 in a two-cycle electrolysis procedure. Three electrode cells were used to perform both electrolyses. In both cycles, working electrodes were kept on constant potential. The pH of the solution was adjusted to 2.7 of the value before the electrolyses. The radionucliclic purity of the Y-90 solution was analysed by ITLC and extraction paper chromatography. The labelling of peptide (100 mu g DOTATATE) with (YCl3)-Y-90 was performed at 95 degrees C for 30 minutes. Radiochemical purity was determined by HPLC and chromatographic separation, using a solid SepPak C-18 column. Results obtained confirmed the efficiency of our electrochemical separation technique and quality control methods for Y-90. The achieved efficiency of the Sr-90/Y-90 generator above 96% of the theoretical value represents a good basis for the further development of this generator. The labelling of the DOTATATE with Y-90 exhibited a high efficiency, too: there was less than 1% of Y-90(3+) in the Y-90-DOTATATE.",
journal = "Nuclear technology and radiation protection",
title = "Electrochemical Separation of 90-Yttrium in the Electrochemical Sr-90/Y-90 Generator and Its Use for Radiolabelling of Dota-Conjugated Somatostatin Analog [Dota(0), Tyr(3)] Octreotate",
volume = "27",
number = "3",
pages = "260-268",
doi = "10.2298/NTRP1203260P"
}
Petrović, Đ., Nikolić, N. S., Stanković, D.,& Đokić, D. Đ.. (2012). Electrochemical Separation of 90-Yttrium in the Electrochemical Sr-90/Y-90 Generator and Its Use for Radiolabelling of Dota-Conjugated Somatostatin Analog [Dota(0), Tyr(3)] Octreotate. in Nuclear technology and radiation protection, 27(3), 260-268.
https://doi.org/10.2298/NTRP1203260P
Petrović Đ, Nikolić NS, Stanković D, Đokić DĐ. Electrochemical Separation of 90-Yttrium in the Electrochemical Sr-90/Y-90 Generator and Its Use for Radiolabelling of Dota-Conjugated Somatostatin Analog [Dota(0), Tyr(3)] Octreotate. in Nuclear technology and radiation protection. 2012;27(3):260-268.
doi:10.2298/NTRP1203260P .
Petrović, Đorđe, Nikolić, Nadežda S., Stanković, Dragana, Đokić, Divna Đ., "Electrochemical Separation of 90-Yttrium in the Electrochemical Sr-90/Y-90 Generator and Its Use for Radiolabelling of Dota-Conjugated Somatostatin Analog [Dota(0), Tyr(3)] Octreotate" in Nuclear technology and radiation protection, 27, no. 3 (2012):260-268,
https://doi.org/10.2298/NTRP1203260P . .
1
4
4

Development of 90Sr/90Y generator using electrochemical separation

Petrović, Đorđe; Đokić, Divna Đ.; Dobrijević, R.; Stanković, Dragana; Glodić, Pavle

(Society of Physical Chemists of Serbia, 2010)

TY  - CONF
AU  - Petrović, Đorđe
AU  - Đokić, Divna Đ.
AU  - Dobrijević, R.
AU  - Stanković, Dragana
AU  - Glodić, Pavle
PY  - 2010
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/9298
AB  - Using of radiopharmaceuticals based on 90Y in the treatment of solid cancer is
increasing in recent years. Therefore, generators have been developed for obtaining
the 90Y using a feature of 90Sr for spontaneous breakthrough and its equilibrium
with 90Y. Electrochemical separation of 90Y from 90Sr has become the basic method
for obtaining 90Y in high radiochemical yield. For the preliminary study, we used
the electrochemical system with two electrochemical cells. Quality control was
performed using extraction paper chromatography (EPC). Preliminary results
showed that the separation completed successfully in both ways, quantity and
quality.
PB  - Society of Physical Chemists of Serbia
C3  - Physical chemistry 2010 : 10th international conference on fundamental and applied aspects of physical chemistry
T1  - Development of 90Sr/90Y generator using electrochemical separation
ER  - 
@conference{
author = "Petrović, Đorđe and Đokić, Divna Đ. and Dobrijević, R. and Stanković, Dragana and Glodić, Pavle",
year = "2010",
abstract = "Using of radiopharmaceuticals based on 90Y in the treatment of solid cancer is
increasing in recent years. Therefore, generators have been developed for obtaining
the 90Y using a feature of 90Sr for spontaneous breakthrough and its equilibrium
with 90Y. Electrochemical separation of 90Y from 90Sr has become the basic method
for obtaining 90Y in high radiochemical yield. For the preliminary study, we used
the electrochemical system with two electrochemical cells. Quality control was
performed using extraction paper chromatography (EPC). Preliminary results
showed that the separation completed successfully in both ways, quantity and
quality.",
publisher = "Society of Physical Chemists of Serbia",
journal = "Physical chemistry 2010 : 10th international conference on fundamental and applied aspects of physical chemistry",
title = "Development of 90Sr/90Y generator using electrochemical separation"
}
Petrović, Đ., Đokić, D. Đ., Dobrijević, R., Stanković, D.,& Glodić, P.. (2010). Development of 90Sr/90Y generator using electrochemical separation. in Physical chemistry 2010 : 10th international conference on fundamental and applied aspects of physical chemistry
Society of Physical Chemists of Serbia..
Petrović Đ, Đokić DĐ, Dobrijević R, Stanković D, Glodić P. Development of 90Sr/90Y generator using electrochemical separation. in Physical chemistry 2010 : 10th international conference on fundamental and applied aspects of physical chemistry. 2010;..
Petrović, Đorđe, Đokić, Divna Đ., Dobrijević, R., Stanković, Dragana, Glodić, Pavle, "Development of 90Sr/90Y generator using electrochemical separation" in Physical chemistry 2010 : 10th international conference on fundamental and applied aspects of physical chemistry (2010).