TY  - CONF
AU  - Spasić-Jokić, Vesna
AU  - Orlić, Milan P.
PY  - 2010
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/6900
AB  - Therapeutic or diagnostic radiopharmaceutical capsule containing (NaI)-I-131 stays in stomach for 15 minutes before the absorption starts, long enough to make possible risky exposure. During the oral application it is reasonable to measure effective dose in stomach. Direct measurements of organ doses are not possible so there is a strong recommendation to estimate them by calculation. The main goal is the I-131 risk assessment. Monte Carlo code MCNP4b was used to model the transport of gamma and beta particles emitted by radionuclide I-131 considered as a point source at the bottom of the stomach. Absorbed energy per unit transformation in stomach and surrounding organs has been calculated. The dose equivalents in these organs have been calculated in aim to determine the effective doses using appropriate tissue weighting factor values. Obtained results had not significant importance for radiation protection but they were important for establishment of new calibration procedures as a part of QA and QC programs in radiopharmaceuticals production and control.
C3  - Journal of Physics: Conference Series
T1  - Monte Carlo Estimation of Patient Effective Dose in Diagnostics Procedures Using I-131
VL  - 238
DO  - 10.1088/1742-6596/238/1/012054
ER  - 

@conference{
author = "Spasić-Jokić, Vesna and Orlić, Milan P.",
year = "2010",
abstract = "Therapeutic or diagnostic radiopharmaceutical capsule containing (NaI)-I-131 stays in stomach for 15 minutes before the absorption starts, long enough to make possible risky exposure. During the oral application it is reasonable to measure effective dose in stomach. Direct measurements of organ doses are not possible so there is a strong recommendation to estimate them by calculation. The main goal is the I-131 risk assessment. Monte Carlo code MCNP4b was used to model the transport of gamma and beta particles emitted by radionuclide I-131 considered as a point source at the bottom of the stomach. Absorbed energy per unit transformation in stomach and surrounding organs has been calculated. The dose equivalents in these organs have been calculated in aim to determine the effective doses using appropriate tissue weighting factor values. Obtained results had not significant importance for radiation protection but they were important for establishment of new calibration procedures as a part of QA and QC programs in radiopharmaceuticals production and control.",
journal = "Journal of Physics: Conference Series",
title = "Monte Carlo Estimation of Patient Effective Dose in Diagnostics Procedures Using I-131",
volume = "238",
doi = "10.1088/1742-6596/238/1/012054"
}

Spasić-Jokić, V.,& Orlić, M. P.. (2010). Monte Carlo Estimation of Patient Effective Dose in Diagnostics Procedures Using I-131. in Journal of Physics: Conference Series, 238.
https://doi.org/10.1088/1742-6596/238/1/012054

Spasić-Jokić V, Orlić MP. Monte Carlo Estimation of Patient Effective Dose in Diagnostics Procedures Using I-131. in Journal of Physics: Conference Series. 2010;238.
doi:10.1088/1742-6596/238/1/012054 .

Spasić-Jokić, Vesna, Orlić, Milan P., "Monte Carlo Estimation of Patient Effective Dose in Diagnostics Procedures Using I-131" in Journal of Physics: Conference Series, 238 (2010),
https://doi.org/10.1088/1742-6596/238/1/012054 . .

TY  - CONF
AU  - Spasić-Jokić, Vesna
AU  - Orlić, Milan P.
PY  - 2009
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/6859
AB  - During the oral application of radionuclide therapy it is from the vital importance to measure effective dose in stomach in which the (NaI)-I-131 therapeutic capsule stays during the 15 minutes which is long enough to make risky exposure. As it is not possible to determine it by direct measurements there is a strong recommendation to estimate the dose by calculation. The main goal is to calculate effective dose and risk as a result of I-131 capsules remaining in stomach before the absorption starts. Monte Carlo code MCNP4b was used to model the transport of gamma and beta particles emitted by radionuclide I-131 treated as a point source at the bottom of the stomach. Absorbed energy per unit transformation in stomach and surrounding organs has been calculated. The dose equivalents in these organs have been calculated in aim to determine the effective doses using appropriate tissue weighting factor values. The local doses in stomach wall reached the values in order of several hundreds of grays in a very short time. In such case the traditional concept of risk is not applicable, so it becomes necessary to create the very new concept which is able to cover higher risks under presented circumstances.
T1  - Estimation of Patient Effective Dose from I-131 Using Monte Carlo Calculation
SP  - 1669
EP  - 1673
UR  - https://hdl.handle.net/21.15107/rcub_vinar_6859
ER  - 

@conference{
author = "Spasić-Jokić, Vesna and Orlić, Milan P.",
year = "2009",
abstract = "During the oral application of radionuclide therapy it is from the vital importance to measure effective dose in stomach in which the (NaI)-I-131 therapeutic capsule stays during the 15 minutes which is long enough to make risky exposure. As it is not possible to determine it by direct measurements there is a strong recommendation to estimate the dose by calculation. The main goal is to calculate effective dose and risk as a result of I-131 capsules remaining in stomach before the absorption starts. Monte Carlo code MCNP4b was used to model the transport of gamma and beta particles emitted by radionuclide I-131 treated as a point source at the bottom of the stomach. Absorbed energy per unit transformation in stomach and surrounding organs has been calculated. The dose equivalents in these organs have been calculated in aim to determine the effective doses using appropriate tissue weighting factor values. The local doses in stomach wall reached the values in order of several hundreds of grays in a very short time. In such case the traditional concept of risk is not applicable, so it becomes necessary to create the very new concept which is able to cover higher risks under presented circumstances.",
title = "Estimation of Patient Effective Dose from I-131 Using Monte Carlo Calculation",
pages = "1669-1673",
url = "https://hdl.handle.net/21.15107/rcub_vinar_6859"
}

Spasić-Jokić, V.,& Orlić, M. P.. (2009). Estimation of Patient Effective Dose from I-131 Using Monte Carlo Calculation. , 1669-1673.
https://hdl.handle.net/21.15107/rcub_vinar_6859

Spasić-Jokić V, Orlić MP. Estimation of Patient Effective Dose from I-131 Using Monte Carlo Calculation. 2009;:1669-1673.
https://hdl.handle.net/21.15107/rcub_vinar_6859 .

Spasić-Jokić, Vesna, Orlić, Milan P., "Estimation of Patient Effective Dose from I-131 Using Monte Carlo Calculation" (2009):1669-1673,
https://hdl.handle.net/21.15107/rcub_vinar_6859 .

TY  - JOUR
AU  - Jovanović, Moma S.
AU  - Popovic, G
AU  - Kapetanovic, V
AU  - Orlić, Milan P.
AU  - Vladimirov, Sote
PY  - 2004
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/2811
AB  - In order to develop a radiopharmaceutical for hepatobiliary scintigraphy with better hepatobiliary properties new ligand for complexation of Tc-99m, 4-iodo-2,6-dimethylphenylcarbamoylmethyl iminodiacetic acid (METHYLIODIDA), was synthesized. Acid-base equilibria of METHYLIODIDA were studied potentiometrically, because these data are important for determination of complex formation conditions. It was established that METHYLIODIDA undergoes a complex acid-base equilibrium due to its zwitterionic nature and four proton-binding sites. The stoichiometric ionization constants were determined at 25 degreesC and constant ionic strength 0.1 M (NaClO4): pK(1) = 1.7 +/- 0.1; pK(2) = 2.44 +/- 0.07; pK(3) = 6.29 +/- 0.02 and pK(4) = 10.91 +/- 0.06, respectively. (C) 2004 Elsevier B.V. All rights reserved.
T2  - Journal of Pharmaceutical and Biomedical Analysis
T1  - Determination of the ionization constants of 4-iodo-2,6-dimethylphenylcarbamoylmethyl iminodiacetic acid
VL  - 35
IS  - 5
SP  - 1257
EP  - 1261
DO  - 10.1016/j.jpba.2004.03.009
ER  - 

@article{
author = "Jovanović, Moma S. and Popovic, G and Kapetanovic, V and Orlić, Milan P. and Vladimirov, Sote",
year = "2004",
abstract = "In order to develop a radiopharmaceutical for hepatobiliary scintigraphy with better hepatobiliary properties new ligand for complexation of Tc-99m, 4-iodo-2,6-dimethylphenylcarbamoylmethyl iminodiacetic acid (METHYLIODIDA), was synthesized. Acid-base equilibria of METHYLIODIDA were studied potentiometrically, because these data are important for determination of complex formation conditions. It was established that METHYLIODIDA undergoes a complex acid-base equilibrium due to its zwitterionic nature and four proton-binding sites. The stoichiometric ionization constants were determined at 25 degreesC and constant ionic strength 0.1 M (NaClO4): pK(1) = 1.7 +/- 0.1; pK(2) = 2.44 +/- 0.07; pK(3) = 6.29 +/- 0.02 and pK(4) = 10.91 +/- 0.06, respectively. (C) 2004 Elsevier B.V. All rights reserved.",
journal = "Journal of Pharmaceutical and Biomedical Analysis",
title = "Determination of the ionization constants of 4-iodo-2,6-dimethylphenylcarbamoylmethyl iminodiacetic acid",
volume = "35",
number = "5",
pages = "1257-1261",
doi = "10.1016/j.jpba.2004.03.009"
}

Jovanović, M. S., Popovic, G., Kapetanovic, V., Orlić, M. P.,& Vladimirov, S.. (2004). Determination of the ionization constants of 4-iodo-2,6-dimethylphenylcarbamoylmethyl iminodiacetic acid. in Journal of Pharmaceutical and Biomedical Analysis, 35(5), 1257-1261.
https://doi.org/10.1016/j.jpba.2004.03.009

Jovanović MS, Popovic G, Kapetanovic V, Orlić MP, Vladimirov S. Determination of the ionization constants of 4-iodo-2,6-dimethylphenylcarbamoylmethyl iminodiacetic acid. in Journal of Pharmaceutical and Biomedical Analysis. 2004;35(5):1257-1261.
doi:10.1016/j.jpba.2004.03.009 .

Jovanović, Moma S., Popovic, G, Kapetanovic, V, Orlić, Milan P., Vladimirov, Sote, "Determination of the ionization constants of 4-iodo-2,6-dimethylphenylcarbamoylmethyl iminodiacetic acid" in Journal of Pharmaceutical and Biomedical Analysis, 35, no. 5 (2004):1257-1261,
https://doi.org/10.1016/j.jpba.2004.03.009 . .

TY  - JOUR
AU  - Janković, Drina
AU  - Đokić, Divna Đ.
AU  - Maksin, Tatjana N.
AU  - Orlić, Milan P.
PY  - 2002
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/2508
AB  - The purpose of this study was to compare some physicochemical characteristics as well as pharmacokinetic behavior of Tc-99m-PAH as a novel renal agent, with Tc-99m-MAG(3) and (OIH)-O-131. Tc-99m-PAH was prepared from lyophilized kit by adding (TcO4-)-Tc-99m. Labeled complex was stabile and high radiochemical purity radiopharmaceutical, with a low percentage of protein bound to human albumin and hydrophilic character. In spite of its smaller renal uptake, Tc-99m-PAH gave satisfactory renal images. Tc-99m-PAH showed faster urinary elimination than Tc-99m-MAG(3) and similar to those one for I-131-OIH. The comparison of pharmacokinetic parameters of Tc-99m-PAH, Tc-99m-MAG(3) and I-131-OIH indicated the favorable characteristics of Tc-99m-PAH.
T2  - Journal of Radioanalytical and Nuclear Chemistry
T1  - Comparison of some physicochemical and pharmacokinetical parameters of Tc-99m-PAH, Tc-99m-MAG(3) and I-131-OIH
VL  - 251
IS  - 3
SP  - 463
EP  - 466
DO  - 10.1023/A:1014894527982
ER  - 

@article{
author = "Janković, Drina and Đokić, Divna Đ. and Maksin, Tatjana N. and Orlić, Milan P.",
year = "2002",
abstract = "The purpose of this study was to compare some physicochemical characteristics as well as pharmacokinetic behavior of Tc-99m-PAH as a novel renal agent, with Tc-99m-MAG(3) and (OIH)-O-131. Tc-99m-PAH was prepared from lyophilized kit by adding (TcO4-)-Tc-99m. Labeled complex was stabile and high radiochemical purity radiopharmaceutical, with a low percentage of protein bound to human albumin and hydrophilic character. In spite of its smaller renal uptake, Tc-99m-PAH gave satisfactory renal images. Tc-99m-PAH showed faster urinary elimination than Tc-99m-MAG(3) and similar to those one for I-131-OIH. The comparison of pharmacokinetic parameters of Tc-99m-PAH, Tc-99m-MAG(3) and I-131-OIH indicated the favorable characteristics of Tc-99m-PAH.",
journal = "Journal of Radioanalytical and Nuclear Chemistry",
title = "Comparison of some physicochemical and pharmacokinetical parameters of Tc-99m-PAH, Tc-99m-MAG(3) and I-131-OIH",
volume = "251",
number = "3",
pages = "463-466",
doi = "10.1023/A:1014894527982"
}

Janković, D., Đokić, D. Đ., Maksin, T. N.,& Orlić, M. P.. (2002). Comparison of some physicochemical and pharmacokinetical parameters of Tc-99m-PAH, Tc-99m-MAG(3) and I-131-OIH. in Journal of Radioanalytical and Nuclear Chemistry, 251(3), 463-466.
https://doi.org/10.1023/A:1014894527982

Janković D, Đokić DĐ, Maksin TN, Orlić MP. Comparison of some physicochemical and pharmacokinetical parameters of Tc-99m-PAH, Tc-99m-MAG(3) and I-131-OIH. in Journal of Radioanalytical and Nuclear Chemistry. 2002;251(3):463-466.
doi:10.1023/A:1014894527982 .

Janković, Drina, Đokić, Divna Đ., Maksin, Tatjana N., Orlić, Milan P., "Comparison of some physicochemical and pharmacokinetical parameters of Tc-99m-PAH, Tc-99m-MAG(3) and I-131-OIH" in Journal of Radioanalytical and Nuclear Chemistry, 251, no. 3 (2002):463-466,
https://doi.org/10.1023/A:1014894527982 . .

TY  - JOUR
AU  - Miljević, Nada R.
AU  - Marković, Mirjana
AU  - Todorović, Dragana
AU  - Cvijović, Mirjana R.
AU  - Golobočanin, Dušan D.
AU  - Orlić, Milan P.
AU  - Veselinović, Dragan S.
PY  - 2001
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/8773
AB  - Depleted uranium (DU) is a by-product of uranium enrichment process and its use is very dangerous and harmful. We measured uranium concentration in the surface soil (0-5 cm depth) from bomb craters caused by cruise missiles in which DU might have been used as counterweights during NATO attack. Total uranium concentration and isotopic ratio were determined using y-spectrometry and inductively coupled plasma method. Obtained results were in the range 1.7 - 22 mg/kg dry soil that was comparable to the uranium values found in off-side locations of Serbian soils.
T2  - Journal of Environmental Protection and Ecology
T1  - Uranium contents from bomb craters
VL  - 2
IS  - 3
SP  - 642
EP  - 648
UR  - https://hdl.handle.net/21.15107/rcub_vinar_8773
ER  - 

@article{
author = "Miljević, Nada R. and Marković, Mirjana and Todorović, Dragana and Cvijović, Mirjana R. and Golobočanin, Dušan D. and Orlić, Milan P. and Veselinović, Dragan S.",
year = "2001",
abstract = "Depleted uranium (DU) is a by-product of uranium enrichment process and its use is very dangerous and harmful. We measured uranium concentration in the surface soil (0-5 cm depth) from bomb craters caused by cruise missiles in which DU might have been used as counterweights during NATO attack. Total uranium concentration and isotopic ratio were determined using y-spectrometry and inductively coupled plasma method. Obtained results were in the range 1.7 - 22 mg/kg dry soil that was comparable to the uranium values found in off-side locations of Serbian soils.",
journal = "Journal of Environmental Protection and Ecology",
title = "Uranium contents from bomb craters",
volume = "2",
number = "3",
pages = "642-648",
url = "https://hdl.handle.net/21.15107/rcub_vinar_8773"
}

Miljević, N. R., Marković, M., Todorović, D., Cvijović, M. R., Golobočanin, D. D., Orlić, M. P.,& Veselinović, D. S.. (2001). Uranium contents from bomb craters. in Journal of Environmental Protection and Ecology, 2(3), 642-648.
https://hdl.handle.net/21.15107/rcub_vinar_8773

Miljević NR, Marković M, Todorović D, Cvijović MR, Golobočanin DD, Orlić MP, Veselinović DS. Uranium contents from bomb craters. in Journal of Environmental Protection and Ecology. 2001;2(3):642-648.
https://hdl.handle.net/21.15107/rcub_vinar_8773 .

Miljević, Nada R., Marković, Mirjana, Todorović, Dragana, Cvijović, Mirjana R., Golobočanin, Dušan D., Orlić, Milan P., Veselinović, Dragan S., "Uranium contents from bomb craters" in Journal of Environmental Protection and Ecology, 2, no. 3 (2001):642-648,
https://hdl.handle.net/21.15107/rcub_vinar_8773 .

TY  - CONF
AU  - Miljević, Nada R.
AU  - Marković, Mirjana
AU  - Golobočanin, Dušan D.
AU  - Todorović, Dragana
AU  - Žujić, Aleksandra
AU  - Orlić, Milan P.
PY  - 2000
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/8779
C3  - Transboundary Pollution - 3. international conference of Balkan Environmental Association (B.EN.A.)
T1  - Uranium content from bomb craters
SP  - 100
EP  - 101
UR  - https://hdl.handle.net/21.15107/rcub_vinar_8779
ER  - 

@conference{
author = "Miljević, Nada R. and Marković, Mirjana and Golobočanin, Dušan D. and Todorović, Dragana and Žujić, Aleksandra and Orlić, Milan P.",
year = "2000",
journal = "Transboundary Pollution - 3. international conference of Balkan Environmental Association (B.EN.A.)",
title = "Uranium content from bomb craters",
pages = "100-101",
url = "https://hdl.handle.net/21.15107/rcub_vinar_8779"
}

Miljević, N. R., Marković, M., Golobočanin, D. D., Todorović, D., Žujić, A.,& Orlić, M. P.. (2000). Uranium content from bomb craters. in Transboundary Pollution - 3. international conference of Balkan Environmental Association (B.EN.A.), 100-101.
https://hdl.handle.net/21.15107/rcub_vinar_8779

Miljević NR, Marković M, Golobočanin DD, Todorović D, Žujić A, Orlić MP. Uranium content from bomb craters. in Transboundary Pollution - 3. international conference of Balkan Environmental Association (B.EN.A.). 2000;:100-101.
https://hdl.handle.net/21.15107/rcub_vinar_8779 .

Miljević, Nada R., Marković, Mirjana, Golobočanin, Dušan D., Todorović, Dragana, Žujić, Aleksandra, Orlić, Milan P., "Uranium content from bomb craters" in Transboundary Pollution - 3. international conference of Balkan Environmental Association (B.EN.A.) (2000):100-101,
https://hdl.handle.net/21.15107/rcub_vinar_8779 .