@article{
author = "Mitrović, Bojan and Gluvić, Zoran and Obradović, Milan M. and Lačković, Milena and Samardžić, Vladimir and Ćirić, Jasmina and Isenović, Esma R.",
year = "2016",
abstract = "Primarni hipotireoidizam negativno utiče na kvalitet života obolelih. Poboljšanje kvaliteta života očekuje se uspostavljanjem eutireoidnog stanja primenom levotiroksina. Kvalitet života se može "proceniti" primenom različitih upitnika, poput upitnika opšteg zdravlja (GHQ12; engl. General Health Questionnaire) i tireoidno specifičnog upitnika (TSQ; engl. Thyroid Symptom Questionnaire). Ciljevi ovog rada su: sumiranje standardno i modifikovano rangiranih odgovora oba upitnika u skorove; ispitivanje postojanja razlika u apsolutnim vrednostima skorova među grupama ispitanika; svrstavanje dobijenih skorova u različite klastere (bez poremećaja, manji poremećaj, veliki poremećaj), i ispitivanje postojanja razlika u distribuciji frekvencija ispitanika među njima. Studija preseka je sprovedena u KBC Zemun i obuhvatila je 90 ispitanica, koje su bile podeljene u tri jednake grupe (30 po grupi): hipotireoidnu bez terapije, eutiroidnu sa levotiroksinom i kontrolnu, eutireoidnu grupu bez terapije. Ispitanice su zaokruživale svoj odgovor na postavljena pitanja upitnika, koji je potom rangovno transformisan pomoću dva modelastandardnog i modifikovanog, a potom zbirno sumiran. Za statističku analizu korišćen je softver SPSS for Windows 18.0. Prosečan nivo tireostimulišućeg hormona (TSH) u ispitivanoj populaciji je iznosio 1,3±0,3 (1,1-2,2) mU/L. Prosečni TSQm, TSQs, GHQm and GHQs skorovi su bili 14±7, 13±6, 11±7, i 11±6 i razlikovali su se među grupama. Najniži skorovi su registrovani u grupi levotiroksinom-tretiranih, nezavisno od modela rangiranja, pri čemu je nivo TSH ukazivao na adekvatnu supstituciju levotiroksinom. Prosečni TSQs/TSQm i GHQs/GHQm skorovi pokazuju međusobnu statističku korelaciju. Skorovi i skorom-definisani klasteri oba primenjena upitnika odgovaraju kliničkoj prezentaciji prikazanoj kroz grupe ispitivane populacije. S obzirom da se prosečni skorovi upitnika međusobno razlikuju, a da oba modela rangovne transformacije istog upitnika daju sličan skor, zaključujemo da je dovoljno koristiti po jedan upitnik iz obe kategorije instrumenata za ispitivanje kvaliteta života. Jednostavnost primene ovih upitnika, nezavisno od modela transformacije dobijenih odgovora u rangove, omogućava njihovu primenu pri započinjanju supstitucije levotiroksinom, ali takođe i proceni efikasnosti primenjene terapije., Primary hypothyroidism negatively affects patients' quality of life. Improving the quality of life is expected by establishing eutyreoid state using levothyroxine therapy. The quality of life can be "assessed" by applying various questionnaires, such as the general health questionnaire (GHQ12) and thyroid symptom questionnaire (TSQ). The aims of present study were to: sum standard and modified-ranked answers of both questionnaires, rank the scores, test differences in the absolute values of the scores between the groups, classify obtained scores in different clusters (no distress, a minor, and major distress), and test differences in the distribution of frequencies of the respondents among them. Cross-sectional study was conducted in Zemun Clinical Hospital and it included 90 subjects. The subjects were divided into three equal groups (30 subjects per group): hypothyroid without treatment, euthyroid with levothyroxine, and control, euthyroid group without treatment. The subjects answered the questions in the questionnaire, and the answers were then transformed into the ranking of two modelsstandard and modified, and then summarized. Statistical analysis was performed using the SPSS for Windows 18.0. The average level of thyroid stimulating hormone (TSH) in the study population was 1.3 ± 0.3 (1.1-2.2) mU/L. Average TSQm, TSQs, GHQm and GHQs scores were 14±7, 13±6, 11±7 and 11±6 and differed between groups. The lowest scores were registered in the group of levothyroxine-treated, regardless of the ranking models, with the level of TSH that indicates an adequate substitution levothyroxine. Average TSQs/TSQm and GHQs/GHQm scores show a statistical correlation with each other. Scores and scores-defined clusters of both questionnaires are appropriate for clinical presentation shown by specific groups of the population. Considering that the average scores of the questionnaire differ from each other, and that both models rank-transformation of the same questionnaire give a similar score, it is sufficient to use one questionnaire from both categories of instruments for testing the quality of life. The ease of applying these questionnaires, independent of the transformation obtained in response ranges and their application when starting levothyroxine substitution, were used to assess the effectiveness of the therapy.",
journal = "Medicinska istraživanja",
title = "Ispitivanje kvaliteta života obolelih od primarne hipotireoze primenom različitih upitnika i metoda njihove obrade, Primary hypothyroidism quality of life assessment by application of different questionnaires and its different processing",
volume = "50",
number = "2",
pages = "1-6",
doi = "10.5937/MedIst1602001M"
}
