TY  - JOUR
AU  - Liu, Yaming
AU  - Antonijević, Đorđe
AU  - Li, Ruining
AU  - Fan, Yuxuan
AU  - Dukić, Ksenija
AU  - Mićić, Milutin
AU  - Yu, Genyu
AU  - Li, Zhiyu
AU  - Đurić, Marija
AU  - Fan, Yifang
PY  - 2021
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10013
AB  - The aim of the present paper is to determine the sex of the individual using three-dimensional geometric and inertial analyses of metatarsal bones. Metatarsals of 60 adult Chinese subjects of both sexes were scanned using Aquilion One-320 Slice CT Scanner. The three-dimensional models of the metatarsals were reconstructed and thereafter a novel software using the center of mass set as the origin and the three principal axes of inertia was employed for model alignment. Eight geometric and inertial variables were assessed: the bone length, bone width, bone height, surface-area-to-volume ratio, bone density and principal moments of inertia around x, y and z axis. Furthermore, the discriminant functions were established using stepwise discriminant function analysis. A cross-validation procedure was performed to evaluate discriminant accuracy of functions. The results indicated that inertial variables exhibit significant sexual dimorphism, especially principal moments of inertia around z axis. The highest dimorphic values were found in surface-area-to-volume ratio, principal moments of inertia around z axis and bone height. The accuracy rate of the discriminant functions for sex determination ranged from 88.3% to 98.3% (88.3% - 98.3% cross-validated). The highest accuracy of function was established based on the 3rd metatarsal bone. This study showed for the first time that the principal moment of inertia of the human bone may be successfully implemented for sex estimation. In conclusion, the sex of the individual can be accurately estimated using a combination of geometric and inertial variables of the metatarsal bones. The accuracy should be further confirmed in a larger sample size and be tested or independently developed for distinct population/age groups before the functions are widely applied in unidentified skeletons in forensic and bioarchaeological contexts.
T2  - Frontiers in Endocrinology
T1  - Study of Sexual Dimorphism in Metatarsal Bones: Geometric and Inertial Analysis of the Three-Dimensional Reconstructed Models
DO  - 10.3389/fendo.2021.734362
ER  - 

@article{
author = "Liu, Yaming and Antonijević, Đorđe and Li, Ruining and Fan, Yuxuan and Dukić, Ksenija and Mićić, Milutin and Yu, Genyu and Li, Zhiyu and Đurić, Marija and Fan, Yifang",
year = "2021",
abstract = "The aim of the present paper is to determine the sex of the individual using three-dimensional geometric and inertial analyses of metatarsal bones. Metatarsals of 60 adult Chinese subjects of both sexes were scanned using Aquilion One-320 Slice CT Scanner. The three-dimensional models of the metatarsals were reconstructed and thereafter a novel software using the center of mass set as the origin and the three principal axes of inertia was employed for model alignment. Eight geometric and inertial variables were assessed: the bone length, bone width, bone height, surface-area-to-volume ratio, bone density and principal moments of inertia around x, y and z axis. Furthermore, the discriminant functions were established using stepwise discriminant function analysis. A cross-validation procedure was performed to evaluate discriminant accuracy of functions. The results indicated that inertial variables exhibit significant sexual dimorphism, especially principal moments of inertia around z axis. The highest dimorphic values were found in surface-area-to-volume ratio, principal moments of inertia around z axis and bone height. The accuracy rate of the discriminant functions for sex determination ranged from 88.3% to 98.3% (88.3% - 98.3% cross-validated). The highest accuracy of function was established based on the 3rd metatarsal bone. This study showed for the first time that the principal moment of inertia of the human bone may be successfully implemented for sex estimation. In conclusion, the sex of the individual can be accurately estimated using a combination of geometric and inertial variables of the metatarsal bones. The accuracy should be further confirmed in a larger sample size and be tested or independently developed for distinct population/age groups before the functions are widely applied in unidentified skeletons in forensic and bioarchaeological contexts.",
journal = "Frontiers in Endocrinology",
title = "Study of Sexual Dimorphism in Metatarsal Bones: Geometric and Inertial Analysis of the Three-Dimensional Reconstructed Models",
doi = "10.3389/fendo.2021.734362"
}

Liu, Y., Antonijević, Đ., Li, R., Fan, Y., Dukić, K., Mićić, M., Yu, G., Li, Z., Đurić, M.,& Fan, Y.. (2021). Study of Sexual Dimorphism in Metatarsal Bones: Geometric and Inertial Analysis of the Three-Dimensional Reconstructed Models. in Frontiers in Endocrinology.
https://doi.org/10.3389/fendo.2021.734362

Liu Y, Antonijević Đ, Li R, Fan Y, Dukić K, Mićić M, Yu G, Li Z, Đurić M, Fan Y. Study of Sexual Dimorphism in Metatarsal Bones: Geometric and Inertial Analysis of the Three-Dimensional Reconstructed Models. in Frontiers in Endocrinology. 2021;.
doi:10.3389/fendo.2021.734362 .

Liu, Yaming, Antonijević, Đorđe, Li, Ruining, Fan, Yuxuan, Dukić, Ksenija, Mićić, Milutin, Yu, Genyu, Li, Zhiyu, Đurić, Marija, Fan, Yifang, "Study of Sexual Dimorphism in Metatarsal Bones: Geometric and Inertial Analysis of the Three-Dimensional Reconstructed Models" in Frontiers in Endocrinology (2021),
https://doi.org/10.3389/fendo.2021.734362 . .

TY  - JOUR
AU  - Yu, Genyu
AU  - Fan, Yuzhou
AU  - Fan, Yuxuan
AU  - Li, Ruining
AU  - Liu, Yaming
AU  - Antonijević, Đorđe
AU  - Milovanović, Petar
AU  - Zhang, Bo
AU  - Li, Zhiyu
AU  - Đurić, Marija
AU  - Fan, Yifang
PY  - 2020
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/9100
AB  - Hallux valgus (HV), the bunion of the first metatarsophalangeal joint (MTPJ), bothers many adults. No consensus has been reached about the causes of HV, be it a hereditary, or acquired, or multifactorial disease. Nor has agreement been reached using MTPJ angle to assess HV based on X-ray because in most cases the assessment of MTPJ is not reliable as it depends on the posture during scanning. In this study, we assume that HV is predominately acquired and that shoe wearing per se is an important player in HV pathogenesis. To verify our hypothesis, a CT-based finite element (FE) model of the first MTPJ of fossil remains of bear-footed Homo naledi was created and compared to that of five contemporary shoe-wearing wrestlers (10 models from two scans at an interval of about 18 months) because Homo naledi's first MTPJ is an ideal model for non-shoe wearing with parallel sesamoid grooves. We developed the first MTPJ structure transformation method and created MTPJ joint capsule model for both Homo naledi and wrestlers. Constraint on the medial side of the first MTPJ capsule was set to simulate shoe-wearing conditions compared to the lack of medial constraint for barefooted conditions. Analysis of eight FE models of different angles for the first MTPJ of Homo naledi was performed by the first MTPJ transformation method and results showed that stress concentrated on the medial capsule of the first MTPJ in simulated shoe-wearing conditions, even at MTPJ angle of 0°. Increase in the first MTPJ angle further increased stress concentration on the medial side, and stress-growth relationship might reveal the causes of HV. We further developed a method to position the first MTPJ in wrestlers and created CT-based models at two time points. It was evident that the first MTPJ angle increased in all but one athlete, with a maximal increase of 4.03 degrees. This verifies our hypothesis that HV might be developed by wearing shoes. Further longitudinal studies with larger sample sizes are needed to additionally validate our results and determine the magnitude of the effects of shoe wearing on development and progression of HV.
T2  - Frontiers in Bioengineering and Biotechnology
T1  - The Role of Footwear in the Pathogenesis of Hallux Valgus: A Proof-of-Concept Finite Element Analysis in Recent Humans and Homo naledi
VL  - 8
DO  - 10.3389/fbioe.2020.00648
ER  - 

@article{
author = "Yu, Genyu and Fan, Yuzhou and Fan, Yuxuan and Li, Ruining and Liu, Yaming and Antonijević, Đorđe and Milovanović, Petar and Zhang, Bo and Li, Zhiyu and Đurić, Marija and Fan, Yifang",
year = "2020",
abstract = "Hallux valgus (HV), the bunion of the first metatarsophalangeal joint (MTPJ), bothers many adults. No consensus has been reached about the causes of HV, be it a hereditary, or acquired, or multifactorial disease. Nor has agreement been reached using MTPJ angle to assess HV based on X-ray because in most cases the assessment of MTPJ is not reliable as it depends on the posture during scanning. In this study, we assume that HV is predominately acquired and that shoe wearing per se is an important player in HV pathogenesis. To verify our hypothesis, a CT-based finite element (FE) model of the first MTPJ of fossil remains of bear-footed Homo naledi was created and compared to that of five contemporary shoe-wearing wrestlers (10 models from two scans at an interval of about 18 months) because Homo naledi's first MTPJ is an ideal model for non-shoe wearing with parallel sesamoid grooves. We developed the first MTPJ structure transformation method and created MTPJ joint capsule model for both Homo naledi and wrestlers. Constraint on the medial side of the first MTPJ capsule was set to simulate shoe-wearing conditions compared to the lack of medial constraint for barefooted conditions. Analysis of eight FE models of different angles for the first MTPJ of Homo naledi was performed by the first MTPJ transformation method and results showed that stress concentrated on the medial capsule of the first MTPJ in simulated shoe-wearing conditions, even at MTPJ angle of 0°. Increase in the first MTPJ angle further increased stress concentration on the medial side, and stress-growth relationship might reveal the causes of HV. We further developed a method to position the first MTPJ in wrestlers and created CT-based models at two time points. It was evident that the first MTPJ angle increased in all but one athlete, with a maximal increase of 4.03 degrees. This verifies our hypothesis that HV might be developed by wearing shoes. Further longitudinal studies with larger sample sizes are needed to additionally validate our results and determine the magnitude of the effects of shoe wearing on development and progression of HV.",
journal = "Frontiers in Bioengineering and Biotechnology",
title = "The Role of Footwear in the Pathogenesis of Hallux Valgus: A Proof-of-Concept Finite Element Analysis in Recent Humans and Homo naledi",
volume = "8",
doi = "10.3389/fbioe.2020.00648"
}

Yu, G., Fan, Y., Fan, Y., Li, R., Liu, Y., Antonijević, Đ., Milovanović, P., Zhang, B., Li, Z., Đurić, M.,& Fan, Y.. (2020). The Role of Footwear in the Pathogenesis of Hallux Valgus: A Proof-of-Concept Finite Element Analysis in Recent Humans and Homo naledi. in Frontiers in Bioengineering and Biotechnology, 8.
https://doi.org/10.3389/fbioe.2020.00648

Yu G, Fan Y, Fan Y, Li R, Liu Y, Antonijević Đ, Milovanović P, Zhang B, Li Z, Đurić M, Fan Y. The Role of Footwear in the Pathogenesis of Hallux Valgus: A Proof-of-Concept Finite Element Analysis in Recent Humans and Homo naledi. in Frontiers in Bioengineering and Biotechnology. 2020;8.
doi:10.3389/fbioe.2020.00648 .

Yu, Genyu, Fan, Yuzhou, Fan, Yuxuan, Li, Ruining, Liu, Yaming, Antonijević, Đorđe, Milovanović, Petar, Zhang, Bo, Li, Zhiyu, Đurić, Marija, Fan, Yifang, "The Role of Footwear in the Pathogenesis of Hallux Valgus: A Proof-of-Concept Finite Element Analysis in Recent Humans and Homo naledi" in Frontiers in Bioengineering and Biotechnology, 8 (2020),
https://doi.org/10.3389/fbioe.2020.00648 . .

TY  - JOUR
AU  - Li, Ruining
AU  - Fan, Yuxuan
AU  - Liu, Yaming
AU  - Antonijević, Đorđe
AU  - Li, Zhiyu
AU  - Đurić, Marija
AU  - Fan, Yifang
PY  - 2019
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/8533
AB  - The collection of 1550 Homo naledi fossil remains includes six tarsal and five metatarsal bones from the right foot, forming a nearly complete humanlike flat foot arch. The missing right medial cuneiform, however, raises our interest to explore the true structure of Homo naledi’s foot arch. We hypothesize that Homo naledi does not have flat foot. To verify our hypothesis, the left medial cuneiform of Homo naledi was mirrored using three-dimensional reconstruction and virtual model analysis. Then, we defined quantities of Euler, standardized the body coordinate system of foot bone and developed a new foot arch reconstruction method based on discrete bones. The reconstructed transverse foot arch corroborated our hypothesis, thus providing biomechanical evidence for interpreting the evolution of human locomotion and bringing novel ideas to the research of the biomechanical mechanism of ankle stability. © 2019, Elsevier GmbH. All rights reserved.
T2  - Journal of Comparative Human Biology
T1  - Homo naledi did not have flat foot
VL  - 70
IS  - 2
SP  - 139
EP  - 146
DO  - 10.1127/homo/2019/1059
ER  - 

@article{
author = "Li, Ruining and Fan, Yuxuan and Liu, Yaming and Antonijević, Đorđe and Li, Zhiyu and Đurić, Marija and Fan, Yifang",
year = "2019",
abstract = "The collection of 1550 Homo naledi fossil remains includes six tarsal and five metatarsal bones from the right foot, forming a nearly complete humanlike flat foot arch. The missing right medial cuneiform, however, raises our interest to explore the true structure of Homo naledi’s foot arch. We hypothesize that Homo naledi does not have flat foot. To verify our hypothesis, the left medial cuneiform of Homo naledi was mirrored using three-dimensional reconstruction and virtual model analysis. Then, we defined quantities of Euler, standardized the body coordinate system of foot bone and developed a new foot arch reconstruction method based on discrete bones. The reconstructed transverse foot arch corroborated our hypothesis, thus providing biomechanical evidence for interpreting the evolution of human locomotion and bringing novel ideas to the research of the biomechanical mechanism of ankle stability. © 2019, Elsevier GmbH. All rights reserved.",
journal = "Journal of Comparative Human Biology",
title = "Homo naledi did not have flat foot",
volume = "70",
number = "2",
pages = "139-146",
doi = "10.1127/homo/2019/1059"
}

Li, R., Fan, Y., Liu, Y., Antonijević, Đ., Li, Z., Đurić, M.,& Fan, Y.. (2019). Homo naledi did not have flat foot. in Journal of Comparative Human Biology, 70(2), 139-146.
https://doi.org/10.1127/homo/2019/1059

Li R, Fan Y, Liu Y, Antonijević Đ, Li Z, Đurić M, Fan Y. Homo naledi did not have flat foot. in Journal of Comparative Human Biology. 2019;70(2):139-146.
doi:10.1127/homo/2019/1059 .

Li, Ruining, Fan, Yuxuan, Liu, Yaming, Antonijević, Đorđe, Li, Zhiyu, Đurić, Marija, Fan, Yifang, "Homo naledi did not have flat foot" in Journal of Comparative Human Biology, 70, no. 2 (2019):139-146,
https://doi.org/10.1127/homo/2019/1059 . .

TY  - JOUR
AU  - Fan, Yuxuan
AU  - Antonijević, Đorđe
AU  - Antić, Svetlana
AU  - Li, Ruining
AU  - Liu, Yaming
AU  - Li, Zhiyu
AU  - Đurić, Marija
AU  - Fan, Yifang
PY  - 2019
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/8427
AB  - The aim of the present study was to develop a new method to reconstruct damaged metatarsophalangeal joint (MTPJ) of Homo naledi's fossil and to deepen the understanding of the first metatarsal head (FMH) morphological adaptation in different gait patterns. To this purpose three methods were introduced. The first served to compare the anthropometric linear and volumetric measurements of Homo naledi's MTPJ to that of 10 various athletes. The second was employed to measure curvature diameter in FMH's medial and lateral grooves for sesamoid bones. The third was used to determine the parallelism between medial and lateral FMH grooves. The anthropometric measurements of middle-distance runner to the greatest extent mimicked that of Homo naledi. Thus, it was used to successfully reconstruct the damaged Homo naledi's MTPJ. The highest curvature diameter of medial FMH groove was found in Homo naledi, while in lateral FMH groove it was the highest in volleyball player, suggesting their increased bear loading. The parallelism of medial and lateral FMH grooves was observed only in Homo naledi, while in investigated athletes it was dis-parallel. Athletes' dis-paralleled structures make first MTPJ simple flexion movement a complicated one: not rotating about one axis, but aboutmany, whichmay result in bringing a negative effect on running. In conclusion, the presented method for the reconstruction of the damaged foot bone paves the way for morphological and structural analysis of modern population and fossil hominins' gait pattern. © 2019 Fan, Antonijević, Antic, Li, Liu, Li, Djuric and Fan.
T2  - Frontiers in Bioengineering and Biotechnology
T1  - Reconstructing the First Metatarsophalangeal Joint of Homo naledi
VL  - 7
IS  - JUL
DO  - 10.3389/fbioe.2019.00167
ER  - 

@article{
author = "Fan, Yuxuan and Antonijević, Đorđe and Antić, Svetlana and Li, Ruining and Liu, Yaming and Li, Zhiyu and Đurić, Marija and Fan, Yifang",
year = "2019",
abstract = "The aim of the present study was to develop a new method to reconstruct damaged metatarsophalangeal joint (MTPJ) of Homo naledi's fossil and to deepen the understanding of the first metatarsal head (FMH) morphological adaptation in different gait patterns. To this purpose three methods were introduced. The first served to compare the anthropometric linear and volumetric measurements of Homo naledi's MTPJ to that of 10 various athletes. The second was employed to measure curvature diameter in FMH's medial and lateral grooves for sesamoid bones. The third was used to determine the parallelism between medial and lateral FMH grooves. The anthropometric measurements of middle-distance runner to the greatest extent mimicked that of Homo naledi. Thus, it was used to successfully reconstruct the damaged Homo naledi's MTPJ. The highest curvature diameter of medial FMH groove was found in Homo naledi, while in lateral FMH groove it was the highest in volleyball player, suggesting their increased bear loading. The parallelism of medial and lateral FMH grooves was observed only in Homo naledi, while in investigated athletes it was dis-parallel. Athletes' dis-paralleled structures make first MTPJ simple flexion movement a complicated one: not rotating about one axis, but aboutmany, whichmay result in bringing a negative effect on running. In conclusion, the presented method for the reconstruction of the damaged foot bone paves the way for morphological and structural analysis of modern population and fossil hominins' gait pattern. © 2019 Fan, Antonijević, Antic, Li, Liu, Li, Djuric and Fan.",
journal = "Frontiers in Bioengineering and Biotechnology",
title = "Reconstructing the First Metatarsophalangeal Joint of Homo naledi",
volume = "7",
number = "JUL",
doi = "10.3389/fbioe.2019.00167"
}

Fan, Y., Antonijević, Đ., Antić, S., Li, R., Liu, Y., Li, Z., Đurić, M.,& Fan, Y.. (2019). Reconstructing the First Metatarsophalangeal Joint of Homo naledi. in Frontiers in Bioengineering and Biotechnology, 7(JUL).
https://doi.org/10.3389/fbioe.2019.00167

Fan Y, Antonijević Đ, Antić S, Li R, Liu Y, Li Z, Đurić M, Fan Y. Reconstructing the First Metatarsophalangeal Joint of Homo naledi. in Frontiers in Bioengineering and Biotechnology. 2019;7(JUL).
doi:10.3389/fbioe.2019.00167 .

Fan, Yuxuan, Antonijević, Đorđe, Antić, Svetlana, Li, Ruining, Liu, Yaming, Li, Zhiyu, Đurić, Marija, Fan, Yifang, "Reconstructing the First Metatarsophalangeal Joint of Homo naledi" in Frontiers in Bioengineering and Biotechnology, 7, no. JUL (2019),
https://doi.org/10.3389/fbioe.2019.00167 . .

TY  - JOUR
AU  - Liu, Yaming
AU  - Li, Ruining
AU  - Fan, Yuxuan
AU  - Antonijević, Đorđe
AU  - Milenković, Petar P.
AU  - Li, Zhiyu Y.
AU  - Đurić, Marija
AU  - Fan, Yifang
PY  - 2018
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/7854
AB  - The finite element method is playing an increasingly important role in osteoporosis screening. An accurate bone geometric model, a prerequisite for the finite element analysis, is affected by voxels. Isotropic voxel has advantages in three-dimensional reconstruction, but field of view setting usually results in anisotropic voxels. The main goal of this study was to investigate the influence of anisotropic voxel on the accuracy of three-dimensional reconstruction of bone geometric models. Sixty metatarsal bones were scanned twice with an interval of 18 months with different fields of view. We reconstructed these metatarsals and compared them. The results showed that there was no significant difference in volume, surface, length, width and height and two principal moments of inertia, indicating that anisotropic voxel caused by field of view setting has a neglectable effect on the three-dimensional reconstruction of bone geometric models, and that using finite element method based on bone geometric model reconstructed by anisotropic voxel to predict bone strength is reliable.
T2  - AIP Advances
T1  - The influence of anisotropic voxel caused by field of view setting on the accuracy of three-dimensional reconstruction of bone geometric models
VL  - 8
IS  - 8
SP  - 085111
DO  - 10.1063/1.5041990
ER  - 

@article{
author = "Liu, Yaming and Li, Ruining and Fan, Yuxuan and Antonijević, Đorđe and Milenković, Petar P. and Li, Zhiyu Y. and Đurić, Marija and Fan, Yifang",
year = "2018",
abstract = "The finite element method is playing an increasingly important role in osteoporosis screening. An accurate bone geometric model, a prerequisite for the finite element analysis, is affected by voxels. Isotropic voxel has advantages in three-dimensional reconstruction, but field of view setting usually results in anisotropic voxels. The main goal of this study was to investigate the influence of anisotropic voxel on the accuracy of three-dimensional reconstruction of bone geometric models. Sixty metatarsal bones were scanned twice with an interval of 18 months with different fields of view. We reconstructed these metatarsals and compared them. The results showed that there was no significant difference in volume, surface, length, width and height and two principal moments of inertia, indicating that anisotropic voxel caused by field of view setting has a neglectable effect on the three-dimensional reconstruction of bone geometric models, and that using finite element method based on bone geometric model reconstructed by anisotropic voxel to predict bone strength is reliable.",
journal = "AIP Advances",
title = "The influence of anisotropic voxel caused by field of view setting on the accuracy of three-dimensional reconstruction of bone geometric models",
volume = "8",
number = "8",
pages = "085111",
doi = "10.1063/1.5041990"
}

Liu, Y., Li, R., Fan, Y., Antonijević, Đ., Milenković, P. P., Li, Z. Y., Đurić, M.,& Fan, Y.. (2018). The influence of anisotropic voxel caused by field of view setting on the accuracy of three-dimensional reconstruction of bone geometric models. in AIP Advances, 8(8), 085111.
https://doi.org/10.1063/1.5041990

Liu Y, Li R, Fan Y, Antonijević Đ, Milenković PP, Li ZY, Đurić M, Fan Y. The influence of anisotropic voxel caused by field of view setting on the accuracy of three-dimensional reconstruction of bone geometric models. in AIP Advances. 2018;8(8):085111.
doi:10.1063/1.5041990 .

Liu, Yaming, Li, Ruining, Fan, Yuxuan, Antonijević, Đorđe, Milenković, Petar P., Li, Zhiyu Y., Đurić, Marija, Fan, Yifang, "The influence of anisotropic voxel caused by field of view setting on the accuracy of three-dimensional reconstruction of bone geometric models" in AIP Advances, 8, no. 8 (2018):085111,
https://doi.org/10.1063/1.5041990 . .