Mrđanović, Jasminka Ž.

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  • Mrđanović, Jasminka Ž. (5)
  • Mrđanović, Jasminka (1)
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Author's Bibliography

The Puzzling Potential of Carbon Nanomaterials: General Properties, Application, and Toxicity

Jović, Danica; Jaćević, Vesna; Kuča, Kamil; Borišev, Ivana; Mrđanović, Jasminka; Petrović, Danijela; Seke, Mariana; Đorđević, Aleksandar

(2020)

TY  - JOUR
AU  - Jović, Danica
AU  - Jaćević, Vesna
AU  - Kuča, Kamil
AU  - Borišev, Ivana
AU  - Mrđanović, Jasminka
AU  - Petrović, Danijela
AU  - Seke, Mariana
AU  - Đorđević, Aleksandar
PY  - 2020
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/9120
AB  - Being a member of the nanofamily, carbon nanomaterials exhibit specific properties that mostly arise from their small size. They have proved to be very promising for application in the technical and biomedical field. A wide spectrum of use implies the inevitable presence of carbon nanomaterials in the environment, thus potentially endangering their whole nature. Although scientists worldwide have conducted research investigating the impact of these materials, it is evident that there are still significant gaps concerning the knowledge of their mechanisms, as well as the prolonged and chronic exposure and effects. This manuscript summarizes the most prominent representatives of carbon nanomaterial groups, giving a brief review of their general physico-chemical properties, the most common use, and toxicity profiles. Toxicity was presented through genotoxicity and the activation of the cell signaling pathways, both including in vitro and in vivo models, mechanisms, and the consequential outcomes. Moreover, the acute toxicity of fullerenol, as one of the most commonly investigated members, was briefly presented in the final part of this review. Thinking small can greatly help us improve our lives, but also obliges us to deeply and comprehensively investigate all the possible consequences that could arise from our pure-hearted scientific ambitions and work.
T2  - Nanomaterials
T1  - The Puzzling Potential of Carbon Nanomaterials: General Properties, Application, and Toxicity
VL  - 10
IS  - 8
SP  - 1508
DO  - 10.3390/nano10081508
ER  - 
@article{
author = "Jović, Danica and Jaćević, Vesna and Kuča, Kamil and Borišev, Ivana and Mrđanović, Jasminka and Petrović, Danijela and Seke, Mariana and Đorđević, Aleksandar",
year = "2020",
url = "https://vinar.vin.bg.ac.rs/handle/123456789/9120",
abstract = "Being a member of the nanofamily, carbon nanomaterials exhibit specific properties that mostly arise from their small size. They have proved to be very promising for application in the technical and biomedical field. A wide spectrum of use implies the inevitable presence of carbon nanomaterials in the environment, thus potentially endangering their whole nature. Although scientists worldwide have conducted research investigating the impact of these materials, it is evident that there are still significant gaps concerning the knowledge of their mechanisms, as well as the prolonged and chronic exposure and effects. This manuscript summarizes the most prominent representatives of carbon nanomaterial groups, giving a brief review of their general physico-chemical properties, the most common use, and toxicity profiles. Toxicity was presented through genotoxicity and the activation of the cell signaling pathways, both including in vitro and in vivo models, mechanisms, and the consequential outcomes. Moreover, the acute toxicity of fullerenol, as one of the most commonly investigated members, was briefly presented in the final part of this review. Thinking small can greatly help us improve our lives, but also obliges us to deeply and comprehensively investigate all the possible consequences that could arise from our pure-hearted scientific ambitions and work.",
journal = "Nanomaterials",
title = "The Puzzling Potential of Carbon Nanomaterials: General Properties, Application, and Toxicity",
volume = "10",
number = "8",
pages = "1508",
doi = "10.3390/nano10081508"
}
Jović, D., Jaćević, V., Kuča, K., Borišev, I., Mrđanović, J., Petrović, D., Seke, M.,& Đorđević, A. (2020). The Puzzling Potential of Carbon Nanomaterials: General Properties, Application, and Toxicity.
Nanomaterials, 10(8), 1508.
https://doi.org/10.3390/nano10081508
Jović D, Jaćević V, Kuča K, Borišev I, Mrđanović J, Petrović D, Seke M, Đorđević A. The Puzzling Potential of Carbon Nanomaterials: General Properties, Application, and Toxicity. Nanomaterials. 2020;10(8):1508
Jović Danica, Jaćević Vesna, Kuča Kamil, Borišev Ivana, Mrđanović Jasminka, Petrović Danijela, Seke Mariana, Đorđević Aleksandar, "The Puzzling Potential of Carbon Nanomaterials: General Properties, Application, and Toxicity" Nanomaterials, 10, no. 8 (2020):1508,
https://doi.org/10.3390/nano10081508 .
1
10
6

Nanoformulations of doxorubicin: How far have we come and where do we go from here?

Borišev, Ivana; Mrđanović, Jasminka Ž.; Petrović, Danijela; Seke, Mariana; Jović, Danica S.; Srđenović, Branislava U.; Latinović, Nataša; Đorđević, Aleksandar N.

(2018)

TY  - JOUR
AU  - Borišev, Ivana
AU  - Mrđanović, Jasminka Ž.
AU  - Petrović, Danijela
AU  - Seke, Mariana
AU  - Jović, Danica S.
AU  - Srđenović, Branislava U.
AU  - Latinović, Nataša
AU  - Đorđević, Aleksandar N.
PY  - 2018
UR  - http://stacks.iop.org/0957-4484/29/i=33/a=332002?key=crossref.4804877570e2609bf6333877ee495ab3
UR  - http://vinar.vin.bg.ac.rs/handle/123456789/7751
AB  - Nanotechnology, focused on discovery and development of new pharmaceutical products is known as nanopharmacology, and one research area this branch is engaged in are nanopharmaceuticals. The importance of being nano has been particularly emphasized in scientific areas dealing with nanomedicine and nanopharmaceuticals. Nanopharmaceuticals, their routes of administration, obstacles and solutions concerning their improved application and enhanced efficacy have been briefly yet comprehensively described. Cancer is one of the leading causes of death worldwide and evergrowing number of scientific research on the topic only confirms that the needs have not been completed yet and that there is a wide platform for improvement. This is undoubtedly true for nanoformulations of an anticancer drug doxorubicin, where various nanocarrriers were given an important role to reduce the drug toxicity, while the efficacy of the drug was supposed to be retained or preferably enhanced. Therefore, we present an interdisciplinary comprehensive overview of interdisciplinary nature on nanopharmaceuticals based on doxorubicin and its nanoformulations with valuable information concerning trends, obstacles and prospective of nanopharmaceuticals development, mode of activity of sole drug doxorubicin and its nanoformulations based on different nanocarriers, their brief descriptions of biological activity through assessing in vitro and in vivo behavior.
T2  - Nanotechnology
T1  - Nanoformulations of doxorubicin: How far have we come and where do we go from here?
VL  - 29
IS  - 33
SP  - 332002
DO  - 10.1088/1361-6528/aac7dd
ER  - 
@article{
author = "Borišev, Ivana and Mrđanović, Jasminka Ž. and Petrović, Danijela and Seke, Mariana and Jović, Danica S. and Srđenović, Branislava U. and Latinović, Nataša and Đorđević, Aleksandar N.",
year = "2018",
url = "http://stacks.iop.org/0957-4484/29/i=33/a=332002?key=crossref.4804877570e2609bf6333877ee495ab3, http://vinar.vin.bg.ac.rs/handle/123456789/7751",
abstract = "Nanotechnology, focused on discovery and development of new pharmaceutical products is known as nanopharmacology, and one research area this branch is engaged in are nanopharmaceuticals. The importance of being nano has been particularly emphasized in scientific areas dealing with nanomedicine and nanopharmaceuticals. Nanopharmaceuticals, their routes of administration, obstacles and solutions concerning their improved application and enhanced efficacy have been briefly yet comprehensively described. Cancer is one of the leading causes of death worldwide and evergrowing number of scientific research on the topic only confirms that the needs have not been completed yet and that there is a wide platform for improvement. This is undoubtedly true for nanoformulations of an anticancer drug doxorubicin, where various nanocarrriers were given an important role to reduce the drug toxicity, while the efficacy of the drug was supposed to be retained or preferably enhanced. Therefore, we present an interdisciplinary comprehensive overview of interdisciplinary nature on nanopharmaceuticals based on doxorubicin and its nanoformulations with valuable information concerning trends, obstacles and prospective of nanopharmaceuticals development, mode of activity of sole drug doxorubicin and its nanoformulations based on different nanocarriers, their brief descriptions of biological activity through assessing in vitro and in vivo behavior.",
journal = "Nanotechnology",
title = "Nanoformulations of doxorubicin: How far have we come and where do we go from here?",
volume = "29",
number = "33",
pages = "332002",
doi = "10.1088/1361-6528/aac7dd"
}
Borišev, I., Mrđanović, J. Ž., Petrović, D., Seke, M., Jović, D. S., Srđenović, B. U., Latinović, N.,& Đorđević, A. N. (2018). Nanoformulations of doxorubicin: How far have we come and where do we go from here?.
Nanotechnology, 29(33), 332002.
https://doi.org/10.1088/1361-6528/aac7dd
Borišev I, Mrđanović JŽ, Petrović D, Seke M, Jović DS, Srđenović BU, Latinović N, Đorđević AN. Nanoformulations of doxorubicin: How far have we come and where do we go from here?. Nanotechnology. 2018;29(33):332002
Borišev Ivana, Mrđanović Jasminka Ž., Petrović Danijela, Seke Mariana, Jović Danica S., Srđenović Branislava U., Latinović Nataša, Đorđević Aleksandar N., "Nanoformulations of doxorubicin: How far have we come and where do we go from here?" Nanotechnology, 29, no. 33 (2018):332002,
https://doi.org/10.1088/1361-6528/aac7dd .
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10
11

Fullerenol nanoparticles as a new delivery system for doxorubicin

Jović, Danica S.; Seke, Mariana; Đorđević, Aleksandar N.; Mrđanović, Jasminka Ž.; Aleksić, Lidija D.; Bogdanovic, Gordana M.; Pavić, Aleksandar B.; Plavec, Janez

(2016)

TY  - JOUR
AU  - Jović, Danica S.
AU  - Seke, Mariana
AU  - Đorđević, Aleksandar N.
AU  - Mrđanović, Jasminka Ž.
AU  - Aleksić, Lidija D.
AU  - Bogdanovic, Gordana M.
AU  - Pavić, Aleksandar B.
AU  - Plavec, Janez
PY  - 2016
UR  - http://vinar.vin.bg.ac.rs/handle/123456789/1042
AB  - Doxorubicin is a very potent chemotherapeutic drug, however its side effects limit its clinical use. The aim of this research was to investigate the properties of a fullerenol/doxorubicin nanocomposite, its potentially cytotoxic and genotoxic effects on malignant cell lines, as well as its toxicity towards zebra fish embryos. Chromatographic, NMR and mass spectral analysis of the nanocomposite imply that interactions between doxorubicin and fullerenol are non-covalent bonds. The stability of the nanocomposite was confirmed by the use of atomic force microscopy, dynamic light scattering and transmission electron microscopy. The nanocomposite, compared to the free doxorubicin at equivalent concentrations, significantly decreased the viability of MCF-7 and MDA-MB-231 cells. The flow cytometry results indicated that doxorubicin-loaded fullerenol could remarkably increase the uptake of doxorubicin suggesting that fullerenol might be a promising intracellular targeting carrier for the efficient delivery of antitumor drugs into tumor cells. The nanocomposite also affected cell cycle distribution. A genotoxicity test showed that the nanocomposite at all examined concentrations on MCF-7 and at lower concentrations on MDA-MB-231 cells caused DNA damage. Consequently, cell proliferation was notably reduced when compared with controls. Results of the zebrafish embryotoxicity assay showed a decreased overall toxicity, particularly cardiotoxicity and increased safety of the nanocomposite in comparison to doxorubicin alone, as manifested by a higher survival of embryos and less pericardial edema.
T2  - RSC Advances
T1  - Fullerenol nanoparticles as a new delivery system for doxorubicin
VL  - 6
IS  - 45
SP  - 38563
EP  - 38578
DO  - 10.1039/c6ra03879d
ER  - 
@article{
author = "Jović, Danica S. and Seke, Mariana and Đorđević, Aleksandar N. and Mrđanović, Jasminka Ž. and Aleksić, Lidija D. and Bogdanovic, Gordana M. and Pavić, Aleksandar B. and Plavec, Janez",
year = "2016",
url = "http://vinar.vin.bg.ac.rs/handle/123456789/1042",
abstract = "Doxorubicin is a very potent chemotherapeutic drug, however its side effects limit its clinical use. The aim of this research was to investigate the properties of a fullerenol/doxorubicin nanocomposite, its potentially cytotoxic and genotoxic effects on malignant cell lines, as well as its toxicity towards zebra fish embryos. Chromatographic, NMR and mass spectral analysis of the nanocomposite imply that interactions between doxorubicin and fullerenol are non-covalent bonds. The stability of the nanocomposite was confirmed by the use of atomic force microscopy, dynamic light scattering and transmission electron microscopy. The nanocomposite, compared to the free doxorubicin at equivalent concentrations, significantly decreased the viability of MCF-7 and MDA-MB-231 cells. The flow cytometry results indicated that doxorubicin-loaded fullerenol could remarkably increase the uptake of doxorubicin suggesting that fullerenol might be a promising intracellular targeting carrier for the efficient delivery of antitumor drugs into tumor cells. The nanocomposite also affected cell cycle distribution. A genotoxicity test showed that the nanocomposite at all examined concentrations on MCF-7 and at lower concentrations on MDA-MB-231 cells caused DNA damage. Consequently, cell proliferation was notably reduced when compared with controls. Results of the zebrafish embryotoxicity assay showed a decreased overall toxicity, particularly cardiotoxicity and increased safety of the nanocomposite in comparison to doxorubicin alone, as manifested by a higher survival of embryos and less pericardial edema.",
journal = "RSC Advances",
title = "Fullerenol nanoparticles as a new delivery system for doxorubicin",
volume = "6",
number = "45",
pages = "38563-38578",
doi = "10.1039/c6ra03879d"
}
Jović, D. S., Seke, M., Đorđević, A. N., Mrđanović, J. Ž., Aleksić, L. D., Bogdanovic, G. M., Pavić, A. B.,& Plavec, J. (2016). Fullerenol nanoparticles as a new delivery system for doxorubicin.
RSC Advances, 6(45), 38563-38578.
https://doi.org/10.1039/c6ra03879d
Jović DS, Seke M, Đorđević AN, Mrđanović JŽ, Aleksić LD, Bogdanovic GM, Pavić AB, Plavec J. Fullerenol nanoparticles as a new delivery system for doxorubicin. RSC Advances. 2016;6(45):38563-38578
Jović Danica S., Seke Mariana, Đorđević Aleksandar N., Mrđanović Jasminka Ž., Aleksić Lidija D., Bogdanovic Gordana M., Pavić Aleksandar B., Plavec Janez, "Fullerenol nanoparticles as a new delivery system for doxorubicin" RSC Advances, 6, no. 45 (2016):38563-38578,
https://doi.org/10.1039/c6ra03879d .
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14
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Review of Synthesis and Antioxidant Potential of Fullerenol Nanoparticles

Đorđević, Aleksandar N.; Srđenović, Branislava U.; Seke, Mariana; Petrović, Danijela; Injac, Rade; Mrđanović, Jasminka Ž.

(2015)

TY  - JOUR
AU  - Đorđević, Aleksandar N.
AU  - Srđenović, Branislava U.
AU  - Seke, Mariana
AU  - Petrović, Danijela
AU  - Injac, Rade
AU  - Mrđanović, Jasminka Ž.
PY  - 2015
UR  - http://vinar.vin.bg.ac.rs/handle/123456789/699
AB  - This review describes the chemical synthesis of polar polyhydroxylated fullerene C-60 derivatives, fullerenols C-60(OH)(n), 2 LT = n LT = 44, C-60 HzOx(OH)(y), and polyanion fullerenols C-60(OH)(15)(ONa)(9), ranging from the very first synthetic methods up to some contemporary approaches to synthesis and separation. It also provides some basic information about physical characteristics of fullerenols. With the increasing number of hydroxyl groups, water solubility of fullerenols increases as well. Fullerenols both in water and biological media build nanoparticles of different dimensions and stability. In different chemical and biological model systems a large number of various polyhydroxylated fullerene derivatives were tested and they showed both their antioxidative and prooxidative characteristics. Several mechanisms have been proposed for the antioxidant activity of fullerenol. In addition, this paper also provides insight into patents referring to the antioxidant properties of fullerenol.
T2  - Journal of Nanomaterials
T1  - Review of Synthesis and Antioxidant Potential of Fullerenol Nanoparticles
DO  - 10.1155/2015/567073
ER  - 
@article{
author = "Đorđević, Aleksandar N. and Srđenović, Branislava U. and Seke, Mariana and Petrović, Danijela and Injac, Rade and Mrđanović, Jasminka Ž.",
year = "2015",
url = "http://vinar.vin.bg.ac.rs/handle/123456789/699",
abstract = "This review describes the chemical synthesis of polar polyhydroxylated fullerene C-60 derivatives, fullerenols C-60(OH)(n), 2 LT = n LT = 44, C-60 HzOx(OH)(y), and polyanion fullerenols C-60(OH)(15)(ONa)(9), ranging from the very first synthetic methods up to some contemporary approaches to synthesis and separation. It also provides some basic information about physical characteristics of fullerenols. With the increasing number of hydroxyl groups, water solubility of fullerenols increases as well. Fullerenols both in water and biological media build nanoparticles of different dimensions and stability. In different chemical and biological model systems a large number of various polyhydroxylated fullerene derivatives were tested and they showed both their antioxidative and prooxidative characteristics. Several mechanisms have been proposed for the antioxidant activity of fullerenol. In addition, this paper also provides insight into patents referring to the antioxidant properties of fullerenol.",
journal = "Journal of Nanomaterials",
title = "Review of Synthesis and Antioxidant Potential of Fullerenol Nanoparticles",
doi = "10.1155/2015/567073"
}
Đorđević, A. N., Srđenović, B. U., Seke, M., Petrović, D., Injac, R.,& Mrđanović, J. Ž. (2015). Review of Synthesis and Antioxidant Potential of Fullerenol Nanoparticles.
Journal of Nanomaterials.
https://doi.org/10.1155/2015/567073
Đorđević AN, Srđenović BU, Seke M, Petrović D, Injac R, Mrđanović JŽ. Review of Synthesis and Antioxidant Potential of Fullerenol Nanoparticles. Journal of Nanomaterials. 2015;
Đorđević Aleksandar N., Srđenović Branislava U., Seke Mariana, Petrović Danijela, Injac Rade, Mrđanović Jasminka Ž., "Review of Synthesis and Antioxidant Potential of Fullerenol Nanoparticles" Journal of Nanomaterials (2015),
https://doi.org/10.1155/2015/567073 .
3
48
43
45

Effects of Fullerenol Nano Particles C-60(Oh)(24) on Micronuclei and Chromosomal Aberrations Frequency in Peripheral Blood Lymphocytes

Mrđanović, Jasminka Ž.; Solajic, Slavica V.; Bogdanovic, Visnja V.; Đorđević, Aleksandar N.; Bogdanovic, Gordana M.; Injac, Rade D.; Rakočević, Zlatko Lj.

(2012)

TY  - JOUR
AU  - Mrđanović, Jasminka Ž.
AU  - Solajic, Slavica V.
AU  - Bogdanovic, Visnja V.
AU  - Đorđević, Aleksandar N.
AU  - Bogdanovic, Gordana M.
AU  - Injac, Rade D.
AU  - Rakočević, Zlatko Lj.
PY  - 2012
UR  - http://vinar.vin.bg.ac.rs/handle/123456789/4935
AB  - Fullerenol C-60(OH)(24) nano particles (FNP) show various biological activities in different experimental models. We evaluated genotoxic and antigenotoxic effects of FNP on human peripheral blood lymphocytes (PBL) using two cytogenetic assays. The effects of FNP were evaluated on the frequency of chromosomal aberrations (CA) and micronuclei (MN) on undamaged and mitomycin C (MMC)-damaged PBL. FNP number distribution in a culture medium with serum showed that predominant particles were about 180 nm and 90 nm respectively. Cytogenetic assays showed that FNP decreased chromosomal aberrations and micronucleus frequency on the undamaged and the MMC- damaged human PBL at concentration range from 5.54 mu M to 221.60 mu M. Our research confirmed that FNP did not exhibit genotoxic but induced antigenotoxic effects at subcytotoxic concentrations on human lymphocytes.
T2  - Digest Journal of Nanomaterials and Biostructures
T1  - Effects of Fullerenol Nano Particles C-60(Oh)(24) on Micronuclei and Chromosomal Aberrations Frequency in Peripheral Blood Lymphocytes
VL  - 7
IS  - 2
SP  - 673
EP  - 686
ER  - 
@article{
author = "Mrđanović, Jasminka Ž. and Solajic, Slavica V. and Bogdanovic, Visnja V. and Đorđević, Aleksandar N. and Bogdanovic, Gordana M. and Injac, Rade D. and Rakočević, Zlatko Lj.",
year = "2012",
url = "http://vinar.vin.bg.ac.rs/handle/123456789/4935",
abstract = "Fullerenol C-60(OH)(24) nano particles (FNP) show various biological activities in different experimental models. We evaluated genotoxic and antigenotoxic effects of FNP on human peripheral blood lymphocytes (PBL) using two cytogenetic assays. The effects of FNP were evaluated on the frequency of chromosomal aberrations (CA) and micronuclei (MN) on undamaged and mitomycin C (MMC)-damaged PBL. FNP number distribution in a culture medium with serum showed that predominant particles were about 180 nm and 90 nm respectively. Cytogenetic assays showed that FNP decreased chromosomal aberrations and micronucleus frequency on the undamaged and the MMC- damaged human PBL at concentration range from 5.54 mu M to 221.60 mu M. Our research confirmed that FNP did not exhibit genotoxic but induced antigenotoxic effects at subcytotoxic concentrations on human lymphocytes.",
journal = "Digest Journal of Nanomaterials and Biostructures",
title = "Effects of Fullerenol Nano Particles C-60(Oh)(24) on Micronuclei and Chromosomal Aberrations Frequency in Peripheral Blood Lymphocytes",
volume = "7",
number = "2",
pages = "673-686"
}
Mrđanović, J. Ž., Solajic, S. V., Bogdanovic, V. V., Đorđević, A. N., Bogdanovic, G. M., Injac, R. D.,& Rakočević, Z. Lj. (2012). Effects of Fullerenol Nano Particles C-60(Oh)(24) on Micronuclei and Chromosomal Aberrations Frequency in Peripheral Blood Lymphocytes.
Digest Journal of Nanomaterials and Biostructures, 7(2), 673-686.
Mrđanović JŽ, Solajic SV, Bogdanovic VV, Đorđević AN, Bogdanovic GM, Injac RD, Rakočević ZL. Effects of Fullerenol Nano Particles C-60(Oh)(24) on Micronuclei and Chromosomal Aberrations Frequency in Peripheral Blood Lymphocytes. Digest Journal of Nanomaterials and Biostructures. 2012;7(2):673-686
Mrđanović Jasminka Ž., Solajic Slavica V., Bogdanovic Visnja V., Đorđević Aleksandar N., Bogdanovic Gordana M., Injac Rade D., Rakočević Zlatko Lj., "Effects of Fullerenol Nano Particles C-60(Oh)(24) on Micronuclei and Chromosomal Aberrations Frequency in Peripheral Blood Lymphocytes" Digest Journal of Nanomaterials and Biostructures, 7, no. 2 (2012):673-686
10

Characteristics of novel myeloid precursor cell line, PC-MDS, established from a bone marrow of the patient with therapy-related myelodysplastic syndrome

Bogdanovic, Gordana; Jurišić, Vladimir; Kraguljac, Nada; Mrđanović, Jasminka Ž.; Jakimov, Dimitar; Krtolica-Žikić, Koviljka; Krajnović, Milena M.; Magic, Zvonko; Stojiljkovic, Bratislav; Andrijevic, Ljiljana; Srdić, Tatjana; Baltic, Mirjana; Popovic, Stevan

(2007)

TY  - JOUR
AU  - Bogdanovic, Gordana
AU  - Jurišić, Vladimir
AU  - Kraguljac, Nada
AU  - Mrđanović, Jasminka Ž.
AU  - Jakimov, Dimitar
AU  - Krtolica-Žikić, Koviljka
AU  - Krajnović, Milena M.
AU  - Magic, Zvonko
AU  - Stojiljkovic, Bratislav
AU  - Andrijevic, Ljiljana
AU  - Srdić, Tatjana
AU  - Baltic, Mirjana
AU  - Popovic, Stevan
PY  - 2007
UR  - http://vinar.vin.bg.ac.rs/handle/123456789/3219
AB  - We report on characteristics of the first human cell line, PC-MDS, derived from a bone marrow of a patient with therapy-related myelodysplastic syndrome (t-MDS) who had no overt post-MDS leukemia. Classic cytology analyses, immunophenotyping, cytogenetic and molecular genetic procedures were used for characterization of the cell line. PC-MDS cells are positive for the expression of CD13, CD15, CD30, CD33, and CD45 antigen. Positive cytochemical staining and immunophenotype analyses indicated that PC-MDS cells have some characteristics of the early myeloid precursor cell. The karyotype analysis of PC-MDS cell line revealed various numerical and structural changes including those typically associated with t-MDS: del(5)(q13)[7], der(5)t(5;11)(p11;q11)[13], -7[6], del(7)(q31)[2], +20[3], -20[4]. Evaluation of methylation status in a promoter region of p 15, p 16 and MGMT genes showed biallelic hypermethylation pattern of 5 promoter region only in MGMT gene. PC-MDS is the first t-MDS derived cell line, and based on its immunological, cytogenetic and molecular characterization could be a new tool in evaluation of complex biology of MDS and a model for methylation studies. (c) 2007 Elsevier Ltd. All rights reserved.
T2  - Leukemia Research
T1  - Characteristics of novel myeloid precursor cell line, PC-MDS, established from a bone marrow of the patient with therapy-related myelodysplastic syndrome
VL  - 31
IS  - 8
SP  - 1097
EP  - 1105
DO  - 10.1016/j.leukres.2007.01.012
ER  - 
@article{
author = "Bogdanovic, Gordana and Jurišić, Vladimir and Kraguljac, Nada and Mrđanović, Jasminka Ž. and Jakimov, Dimitar and Krtolica-Žikić, Koviljka and Krajnović, Milena M. and Magic, Zvonko and Stojiljkovic, Bratislav and Andrijevic, Ljiljana and Srdić, Tatjana and Baltic, Mirjana and Popovic, Stevan",
year = "2007",
url = "http://vinar.vin.bg.ac.rs/handle/123456789/3219",
abstract = "We report on characteristics of the first human cell line, PC-MDS, derived from a bone marrow of a patient with therapy-related myelodysplastic syndrome (t-MDS) who had no overt post-MDS leukemia. Classic cytology analyses, immunophenotyping, cytogenetic and molecular genetic procedures were used for characterization of the cell line. PC-MDS cells are positive for the expression of CD13, CD15, CD30, CD33, and CD45 antigen. Positive cytochemical staining and immunophenotype analyses indicated that PC-MDS cells have some characteristics of the early myeloid precursor cell. The karyotype analysis of PC-MDS cell line revealed various numerical and structural changes including those typically associated with t-MDS: del(5)(q13)[7], der(5)t(5;11)(p11;q11)[13], -7[6], del(7)(q31)[2], +20[3], -20[4]. Evaluation of methylation status in a promoter region of p 15, p 16 and MGMT genes showed biallelic hypermethylation pattern of 5 promoter region only in MGMT gene. PC-MDS is the first t-MDS derived cell line, and based on its immunological, cytogenetic and molecular characterization could be a new tool in evaluation of complex biology of MDS and a model for methylation studies. (c) 2007 Elsevier Ltd. All rights reserved.",
journal = "Leukemia Research",
title = "Characteristics of novel myeloid precursor cell line, PC-MDS, established from a bone marrow of the patient with therapy-related myelodysplastic syndrome",
volume = "31",
number = "8",
pages = "1097-1105",
doi = "10.1016/j.leukres.2007.01.012"
}
Bogdanovic, G., Jurišić, V., Kraguljac, N., Mrđanović, J. Ž., Jakimov, D., Krtolica-Žikić, K., Krajnović, M. M., Magic, Z., Stojiljkovic, B., Andrijevic, L., Srdić, T., Baltic, M.,& Popovic, S. (2007). Characteristics of novel myeloid precursor cell line, PC-MDS, established from a bone marrow of the patient with therapy-related myelodysplastic syndrome.
Leukemia Research, 31(8), 1097-1105.
https://doi.org/10.1016/j.leukres.2007.01.012
Bogdanovic G, Jurišić V, Kraguljac N, Mrđanović JŽ, Jakimov D, Krtolica-Žikić K, Krajnović MM, Magic Z, Stojiljkovic B, Andrijevic L, Srdić T, Baltic M, Popovic S. Characteristics of novel myeloid precursor cell line, PC-MDS, established from a bone marrow of the patient with therapy-related myelodysplastic syndrome. Leukemia Research. 2007;31(8):1097-1105
Bogdanovic Gordana, Jurišić Vladimir, Kraguljac Nada, Mrđanović Jasminka Ž., Jakimov Dimitar, Krtolica-Žikić Koviljka, Krajnović Milena M., Magic Zvonko, Stojiljkovic Bratislav, Andrijevic Ljiljana, Srdić Tatjana, Baltic Mirjana, Popovic Stevan, "Characteristics of novel myeloid precursor cell line, PC-MDS, established from a bone marrow of the patient with therapy-related myelodysplastic syndrome" Leukemia Research, 31, no. 8 (2007):1097-1105,
https://doi.org/10.1016/j.leukres.2007.01.012 .
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