Puškaš, Nela

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  • Puškaš, Nela (8)
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Author's Bibliography

Oxytocin modulates the expression of norepinephrine transporter, β3-adrenoceptors and muscarinic M2 receptors in the hearts of socially isolated rats

Jovanović, Predrag; Spasojević, Nataša; Puškaš, Nela; Stefanović, Bojana; Dronjak, Slađana

(2019)

TY  - JOUR
AU  - Jovanović, Predrag
AU  - Spasojević, Nataša
AU  - Puškaš, Nela
AU  - Stefanović, Bojana
AU  - Dronjak, Slađana
PY  - 2019
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/8400
AB  - Social stress produces behavioral alterations, and autonomic and cardiac dysfunction in animals. In addition to the well-known roles of oxytocin on birth and maternal bonding, recent evidence shows that this neuropeptide possesses cardio-protective properties. However less is known about its role in the regulation of the autonomic nervous system. The direct influence of oxytocin on the cardiac catecholamine synthesizing enzyme, transport beta-adrenoceptors and muscarinic receptors in animals exposed to chronic social isolation stress has not yet been studied. In this study, we examined the influence of peripheral chronic oxytocin treatment on anxiety-related behavior, the morphology and content of epinephrine and norepinephrine, mRNA and protein levels of tyrosine hydroxylase (TH), norepinephrine transporter (NET) and receptors <beta> 3 (β3-AR) and muscarinic 2 (M2 MR) in the right and left cardiac atrium and ventricle of chronically socially isolated male rats. Our results show that oxytocin treatment exhibits an anxiolytic effect, decreases the heart/body weight ratio and prevents the hypertrophy of cardiomyocytes in the wall of the left ventricle of stressed rats. Epinephrine and TH protein levels were unchanged after prolonged oxytocin treatment. Peripheral oxytocin administration led to the enhancement of gene expression of β3-AR in both atria, NET protein in the left ventricle and gene expression of M2 MR in the right atrium and the left ventricle of chronically socially isolated rats. The study provides evidence that oxytocin treatment in chronically socially isolated animals enhances norepinephrine uptake and expression of cardio-inhibitory receptors in cardiac tissues, which could have a beneficial effect on the cardiovascular system under the increased activity of the sympathoneural system. © 2018 Elsevier Inc.
T2  - Peptides
T1  - Oxytocin modulates the expression of norepinephrine transporter, β3-adrenoceptors and muscarinic M2 receptors in the hearts of socially isolated rats
VL  - 111
SP  - 132
EP  - 141
DO  - 10.1016/j.peptides.2018.06.008
ER  - 
@article{
author = "Jovanović, Predrag and Spasojević, Nataša and Puškaš, Nela and Stefanović, Bojana and Dronjak, Slađana",
year = "2019",
abstract = "Social stress produces behavioral alterations, and autonomic and cardiac dysfunction in animals. In addition to the well-known roles of oxytocin on birth and maternal bonding, recent evidence shows that this neuropeptide possesses cardio-protective properties. However less is known about its role in the regulation of the autonomic nervous system. The direct influence of oxytocin on the cardiac catecholamine synthesizing enzyme, transport beta-adrenoceptors and muscarinic receptors in animals exposed to chronic social isolation stress has not yet been studied. In this study, we examined the influence of peripheral chronic oxytocin treatment on anxiety-related behavior, the morphology and content of epinephrine and norepinephrine, mRNA and protein levels of tyrosine hydroxylase (TH), norepinephrine transporter (NET) and receptors <beta> 3 (β3-AR) and muscarinic 2 (M2 MR) in the right and left cardiac atrium and ventricle of chronically socially isolated male rats. Our results show that oxytocin treatment exhibits an anxiolytic effect, decreases the heart/body weight ratio and prevents the hypertrophy of cardiomyocytes in the wall of the left ventricle of stressed rats. Epinephrine and TH protein levels were unchanged after prolonged oxytocin treatment. Peripheral oxytocin administration led to the enhancement of gene expression of β3-AR in both atria, NET protein in the left ventricle and gene expression of M2 MR in the right atrium and the left ventricle of chronically socially isolated rats. The study provides evidence that oxytocin treatment in chronically socially isolated animals enhances norepinephrine uptake and expression of cardio-inhibitory receptors in cardiac tissues, which could have a beneficial effect on the cardiovascular system under the increased activity of the sympathoneural system. © 2018 Elsevier Inc.",
journal = "Peptides",
title = "Oxytocin modulates the expression of norepinephrine transporter, β3-adrenoceptors and muscarinic M2 receptors in the hearts of socially isolated rats",
volume = "111",
pages = "132-141",
doi = "10.1016/j.peptides.2018.06.008"
}
Jovanović, P., Spasojević, N., Puškaš, N., Stefanović, B.,& Dronjak, S.. (2019). Oxytocin modulates the expression of norepinephrine transporter, β3-adrenoceptors and muscarinic M2 receptors in the hearts of socially isolated rats. in Peptides, 111, 132-141.
https://doi.org/10.1016/j.peptides.2018.06.008
Jovanović P, Spasojević N, Puškaš N, Stefanović B, Dronjak S. Oxytocin modulates the expression of norepinephrine transporter, β3-adrenoceptors and muscarinic M2 receptors in the hearts of socially isolated rats. in Peptides. 2019;111:132-141.
doi:10.1016/j.peptides.2018.06.008 .
Jovanović, Predrag, Spasojević, Nataša, Puškaš, Nela, Stefanović, Bojana, Dronjak, Slađana, "Oxytocin modulates the expression of norepinephrine transporter, β3-adrenoceptors and muscarinic M2 receptors in the hearts of socially isolated rats" in Peptides, 111 (2019):132-141,
https://doi.org/10.1016/j.peptides.2018.06.008 . .
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Hippocampal BDNF in physiological conditions and social isolation

Zaletel, Ivan; Filipović, Dragana; Puškaš, Nela

(2017)

TY  - JOUR
AU  - Zaletel, Ivan
AU  - Filipović, Dragana
AU  - Puškaš, Nela
PY  - 2017
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/1664
AB  - Exposure of an organism to chronic psychosocial stress may affect brain-derived neurotrophic factor (BDNF) expression that has been implicated in the etiology of psychiatric disorders, such as depression. Given that depression in humans has been linked with social stress, the chronic social stress paradigms for modeling psychiatric disorders in animals have thus been developed. Chronic social isolation in animal models generally causes changes in hypothalamic-pituitary-adrenal axis functioning, associated with anxiety-and depressive-like behaviors. Also, this chronic stress causes downregulation of BDNF protein and mRNA in the hippocampus, a stress-sensitive brain region closely related to the pathophysiology of depression. In this review, we discuss the current knowledge regarding the structure, function, intracellular signaling, inter-individual differences and epigenetic regulation of BDNF in both physiological conditions and depression and changes in corticosterone levels, as a marker of stress response. Since BDNF levels are age dependent in humans and rodents, this review will also highlight the effects of adolescent and adult chronic social isolation models of both genders on the BDNF expression.
T2  - Reviews in the Neurosciences
T1  - Hippocampal BDNF in physiological conditions and social isolation
VL  - 28
IS  - 6
SP  - 675
EP  - 692
DO  - 10.1515/revneuro-2016-0072
ER  - 
@article{
author = "Zaletel, Ivan and Filipović, Dragana and Puškaš, Nela",
year = "2017",
abstract = "Exposure of an organism to chronic psychosocial stress may affect brain-derived neurotrophic factor (BDNF) expression that has been implicated in the etiology of psychiatric disorders, such as depression. Given that depression in humans has been linked with social stress, the chronic social stress paradigms for modeling psychiatric disorders in animals have thus been developed. Chronic social isolation in animal models generally causes changes in hypothalamic-pituitary-adrenal axis functioning, associated with anxiety-and depressive-like behaviors. Also, this chronic stress causes downregulation of BDNF protein and mRNA in the hippocampus, a stress-sensitive brain region closely related to the pathophysiology of depression. In this review, we discuss the current knowledge regarding the structure, function, intracellular signaling, inter-individual differences and epigenetic regulation of BDNF in both physiological conditions and depression and changes in corticosterone levels, as a marker of stress response. Since BDNF levels are age dependent in humans and rodents, this review will also highlight the effects of adolescent and adult chronic social isolation models of both genders on the BDNF expression.",
journal = "Reviews in the Neurosciences",
title = "Hippocampal BDNF in physiological conditions and social isolation",
volume = "28",
number = "6",
pages = "675-692",
doi = "10.1515/revneuro-2016-0072"
}
Zaletel, I., Filipović, D.,& Puškaš, N.. (2017). Hippocampal BDNF in physiological conditions and social isolation. in Reviews in the Neurosciences, 28(6), 675-692.
https://doi.org/10.1515/revneuro-2016-0072
Zaletel I, Filipović D, Puškaš N. Hippocampal BDNF in physiological conditions and social isolation. in Reviews in the Neurosciences. 2017;28(6):675-692.
doi:10.1515/revneuro-2016-0072 .
Zaletel, Ivan, Filipović, Dragana, Puškaš, Nela, "Hippocampal BDNF in physiological conditions and social isolation" in Reviews in the Neurosciences, 28, no. 6 (2017):675-692,
https://doi.org/10.1515/revneuro-2016-0072 . .
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Chronic stress, hippocampus and parvalbumin-positive interneurons: what do we know so far?

Zaletel, Ivan; Filipović, Dragana; Puškaš, Nela

(2016)

TY  - JOUR
AU  - Zaletel, Ivan
AU  - Filipović, Dragana
AU  - Puškaš, Nela
PY  - 2016
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/1088
AB  - The hippocampus is a brain structure involved in the regulation of hypothalamic-pituitary-adrenal (HPA) axis and stress response. It plays an important role in the formation of declarative, spatial and contextual memory, as well as in the processing of emotional information. As a part of the limbic system, it is a very susceptible structure towards the effects of various stressors. The molecular mechanisms of structural and functional alternations that occur in the hippocampus under chronic stress imply an increased level of circulating glucocorticoids (GCs), which is an HPA axis response to stress. Certain data show that changes induced by chronic stress may be independent from the GCs levels, opening the possibility of existence of other poorly explored mechanisms and pathways through which stressors act. The hippocampal GABAergic parvalbumin-positive (PV+) interneurons represent an especially vulnerable population of neurons in chronic stress, which may be of key importance in the development of mood disorders. However, cellular and molecular hippocampal changes that arise as a consequence of chronic stress still represent a large and unexplored area. This review discusses the current knowledge about the PV+ interneurons of the hippocampus and the influence of chronic stress on this intriguing population of neurons.
T2  - Reviews in the Neurosciences
T1  - Chronic stress, hippocampus and parvalbumin-positive interneurons: what do we know so far?
VL  - 27
IS  - 4
SP  - 397
EP  - 409
DO  - 10.1515/revneuro-2015-0042
ER  - 
@article{
author = "Zaletel, Ivan and Filipović, Dragana and Puškaš, Nela",
year = "2016",
abstract = "The hippocampus is a brain structure involved in the regulation of hypothalamic-pituitary-adrenal (HPA) axis and stress response. It plays an important role in the formation of declarative, spatial and contextual memory, as well as in the processing of emotional information. As a part of the limbic system, it is a very susceptible structure towards the effects of various stressors. The molecular mechanisms of structural and functional alternations that occur in the hippocampus under chronic stress imply an increased level of circulating glucocorticoids (GCs), which is an HPA axis response to stress. Certain data show that changes induced by chronic stress may be independent from the GCs levels, opening the possibility of existence of other poorly explored mechanisms and pathways through which stressors act. The hippocampal GABAergic parvalbumin-positive (PV+) interneurons represent an especially vulnerable population of neurons in chronic stress, which may be of key importance in the development of mood disorders. However, cellular and molecular hippocampal changes that arise as a consequence of chronic stress still represent a large and unexplored area. This review discusses the current knowledge about the PV+ interneurons of the hippocampus and the influence of chronic stress on this intriguing population of neurons.",
journal = "Reviews in the Neurosciences",
title = "Chronic stress, hippocampus and parvalbumin-positive interneurons: what do we know so far?",
volume = "27",
number = "4",
pages = "397-409",
doi = "10.1515/revneuro-2015-0042"
}
Zaletel, I., Filipović, D.,& Puškaš, N.. (2016). Chronic stress, hippocampus and parvalbumin-positive interneurons: what do we know so far?. in Reviews in the Neurosciences, 27(4), 397-409.
https://doi.org/10.1515/revneuro-2015-0042
Zaletel I, Filipović D, Puškaš N. Chronic stress, hippocampus and parvalbumin-positive interneurons: what do we know so far?. in Reviews in the Neurosciences. 2016;27(4):397-409.
doi:10.1515/revneuro-2015-0042 .
Zaletel, Ivan, Filipović, Dragana, Puškaš, Nela, "Chronic stress, hippocampus and parvalbumin-positive interneurons: what do we know so far?" in Reviews in the Neurosciences, 27, no. 4 (2016):397-409,
https://doi.org/10.1515/revneuro-2015-0042 . .
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Effects of oxytocin on adreno-medullary catecholamine synthesis, uptake and storage in rats exposed to chronic isolation stress

Jovanović, Predrag; Stefanović, Bojana; Spasojević, Nataša; Puškaš, Nela; Dronjak, Slađana

(Taylor & Francis, 2016)

TY  - JOUR
AU  - Jovanović, Predrag
AU  - Stefanović, Bojana
AU  - Spasojević, Nataša
AU  - Puškaš, Nela
AU  - Dronjak, Slađana
PY  - 2016
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/1074
AB  - Purpose/aim: The adreno-medullar system represents one of the main systems involved in the response to stressful events. The neuropeptide oxytocin, is highly sensitive to the social environment, and regulates autonomic function. Adreno-medullary activity is dependent on the synthesis of catecholamine, its reuptake, release, degradation and vesicular transport. A direct influence of oxytocin on catecholamine synthesizing enzyme and transports in animals exposed to chronic social isolation stress has not been studied yet. Materials and methods: In the present study, we examined the effect of chronic oxytocin treatment on the level of plasma catecholamine and its content, mRNA and protein levels of tyrosine hydroxylase (TH), noradrenaline transporter (NET) as well as vesicular monoamine transporter 2 (VMAT2) in the adrenal medulla of socially isolated rats. Results: Our results show that, by the end of 12 weeks, social isolation did not produce any significant changes in catecholamine content but increased plasma catecholamine level and synthesis in the adrenal medulla. Oxytocin treatment had no further effect either on catecholamine synthesis or content in socially stressed animals whereas a significant elevation of plasma norepinephrine and epinephrine were reduced. On the other hand, chronic isolation caused a significant increase in VMAT2 and decrease in NET protein levels. Oxytocin treatment brought about an increase in protein levels of NET and its return to the levels of control group. Besides, it further increases VMAT2 protein levels in the adrenal medulla of individually housed rats. Conclusion: The present results show that peripheral oxytocin treatment enhances catecholamine uptake and storage in the adrenal medulla of chronically isolated animals.
PB  - Taylor & Francis
T2  - Endocrine Research
T1  - Effects of oxytocin on adreno-medullary catecholamine synthesis, uptake and storage in rats exposed to chronic isolation stress
VL  - 41
IS  - 2
SP  - 124
EP  - 131
DO  - 10.3109/07435800.2015.1094086
ER  - 
@article{
author = "Jovanović, Predrag and Stefanović, Bojana and Spasojević, Nataša and Puškaš, Nela and Dronjak, Slađana",
year = "2016",
abstract = "Purpose/aim: The adreno-medullar system represents one of the main systems involved in the response to stressful events. The neuropeptide oxytocin, is highly sensitive to the social environment, and regulates autonomic function. Adreno-medullary activity is dependent on the synthesis of catecholamine, its reuptake, release, degradation and vesicular transport. A direct influence of oxytocin on catecholamine synthesizing enzyme and transports in animals exposed to chronic social isolation stress has not been studied yet. Materials and methods: In the present study, we examined the effect of chronic oxytocin treatment on the level of plasma catecholamine and its content, mRNA and protein levels of tyrosine hydroxylase (TH), noradrenaline transporter (NET) as well as vesicular monoamine transporter 2 (VMAT2) in the adrenal medulla of socially isolated rats. Results: Our results show that, by the end of 12 weeks, social isolation did not produce any significant changes in catecholamine content but increased plasma catecholamine level and synthesis in the adrenal medulla. Oxytocin treatment had no further effect either on catecholamine synthesis or content in socially stressed animals whereas a significant elevation of plasma norepinephrine and epinephrine were reduced. On the other hand, chronic isolation caused a significant increase in VMAT2 and decrease in NET protein levels. Oxytocin treatment brought about an increase in protein levels of NET and its return to the levels of control group. Besides, it further increases VMAT2 protein levels in the adrenal medulla of individually housed rats. Conclusion: The present results show that peripheral oxytocin treatment enhances catecholamine uptake and storage in the adrenal medulla of chronically isolated animals.",
publisher = "Taylor & Francis",
journal = "Endocrine Research",
title = "Effects of oxytocin on adreno-medullary catecholamine synthesis, uptake and storage in rats exposed to chronic isolation stress",
volume = "41",
number = "2",
pages = "124-131",
doi = "10.3109/07435800.2015.1094086"
}
Jovanović, P., Stefanović, B., Spasojević, N., Puškaš, N.,& Dronjak, S.. (2016). Effects of oxytocin on adreno-medullary catecholamine synthesis, uptake and storage in rats exposed to chronic isolation stress. in Endocrine Research
Taylor & Francis., 41(2), 124-131.
https://doi.org/10.3109/07435800.2015.1094086
Jovanović P, Stefanović B, Spasojević N, Puškaš N, Dronjak S. Effects of oxytocin on adreno-medullary catecholamine synthesis, uptake and storage in rats exposed to chronic isolation stress. in Endocrine Research. 2016;41(2):124-131.
doi:10.3109/07435800.2015.1094086 .
Jovanović, Predrag, Stefanović, Bojana, Spasojević, Nataša, Puškaš, Nela, Dronjak, Slađana, "Effects of oxytocin on adreno-medullary catecholamine synthesis, uptake and storage in rats exposed to chronic isolation stress" in Endocrine Research, 41, no. 2 (2016):124-131,
https://doi.org/10.3109/07435800.2015.1094086 . .
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2
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2

Effects of methionine-enriched diet on the rat heart and aorta

Đurić, Dragan M.; Stanojlović, Olivera; Hrnčić, Dragan; Puškaš, Nela; Rašić-Marković, Aleksandra; Čolović, Mirjana B.; Krstić, Danijela Z.; Bjekić, J. M.; Grubač, Željko; Šutulović, Nikola; Šušić, Veselinka

(Wiley, 2014)

TY  - CONF
AU  - Đurić, Dragan M.
AU  - Stanojlović, Olivera
AU  - Hrnčić, Dragan
AU  - Puškaš, Nela
AU  - Rašić-Marković, Aleksandra
AU  - Čolović, Mirjana B.
AU  - Krstić, Danijela Z.
AU  - Bjekić, J. M.
AU  - Grubač, Željko
AU  - Šutulović, Nikola
AU  - Šušić, Veselinka
PY  - 2014
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/72
PB  - Wiley
C3  - Acta Physiologica
T1  - Effects of methionine-enriched diet on the rat heart and aorta
VL  - 211
IS  - SI
SP  - 78
EP  - 78
DO  - 10.1111/apha.12362
ER  - 
@conference{
author = "Đurić, Dragan M. and Stanojlović, Olivera and Hrnčić, Dragan and Puškaš, Nela and Rašić-Marković, Aleksandra and Čolović, Mirjana B. and Krstić, Danijela Z. and Bjekić, J. M. and Grubač, Željko and Šutulović, Nikola and Šušić, Veselinka",
year = "2014",
publisher = "Wiley",
journal = "Acta Physiologica",
title = "Effects of methionine-enriched diet on the rat heart and aorta",
volume = "211",
number = "SI",
pages = "78-78",
doi = "10.1111/apha.12362"
}
Đurić, D. M., Stanojlović, O., Hrnčić, D., Puškaš, N., Rašić-Marković, A., Čolović, M. B., Krstić, D. Z., Bjekić, J. M., Grubač, Ž., Šutulović, N.,& Šušić, V.. (2014). Effects of methionine-enriched diet on the rat heart and aorta. in Acta Physiologica
Wiley., 211(SI), 78-78.
https://doi.org/10.1111/apha.12362
Đurić DM, Stanojlović O, Hrnčić D, Puškaš N, Rašić-Marković A, Čolović MB, Krstić DZ, Bjekić JM, Grubač Ž, Šutulović N, Šušić V. Effects of methionine-enriched diet on the rat heart and aorta. in Acta Physiologica. 2014;211(SI):78-78.
doi:10.1111/apha.12362 .
Đurić, Dragan M., Stanojlović, Olivera, Hrnčić, Dragan, Puškaš, Nela, Rašić-Marković, Aleksandra, Čolović, Mirjana B., Krstić, Danijela Z., Bjekić, J. M., Grubač, Željko, Šutulović, Nikola, Šušić, Veselinka, "Effects of methionine-enriched diet on the rat heart and aorta" in Acta Physiologica, 211, no. SI (2014):78-78,
https://doi.org/10.1111/apha.12362 . .
1

Immunohistochemical Detection and Gene Expression of Tyrosine Hydroxylase and Vesicular Monoamine Transporter Type 2 in Intrinsic Cardiac Ganglia of Socially Isolated Rats

Jovanović, Predrag; Puškaš, Nela; Stefanović, Bojana; Spasojević, Nataša; Dronjak, Slađana

(2014)

TY  - JOUR
AU  - Jovanović, Predrag
AU  - Puškaš, Nela
AU  - Stefanović, Bojana
AU  - Spasojević, Nataša
AU  - Dronjak, Slađana
PY  - 2014
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/300
AB  - Social isolation induced a significant increase in resting heart rate and reduction in heart rate variability. Dysfunction of the intrinsic cardiac nervous system is implicated in the genesis of cardiovascular diseases. Previous evidence suggests that cardiac ganglia contain noradrenergic neurons. Thus, immunohistochemical expression of catecholamine-synthesizing enzyme tyrosine hydroxylase (TH) and vesicular monoamine transporter 2 (VMAT2) were analyzed, as well as the effects of social isolation stress on mRNA and protein levels of this enzyme and transporter in the intrinsic cardiac nervous system of adult rats. Our results indicate that cardiac ganglion neurons express TH and VMAT2 immunoreactivity. Chronic isolated stress of rats caused a decrease in TH mRNA and VMAT2 mRNA in the neurons of intrinsic cardiac ganglia. No significant alterations in the protein levels of TH and VMAT2 were observed in these neurons. These data indicate that the neurons of intrinsic cardiac ganglia express TH as well as VMAT2 but that social isolation stress does not change their protein levels.
T2  - Archives of biological sciences
T1  - Immunohistochemical Detection and Gene Expression of Tyrosine Hydroxylase and Vesicular Monoamine Transporter Type 2 in Intrinsic Cardiac Ganglia of Socially Isolated Rats
VL  - 66
IS  - 4
SP  - 1645
EP  - 1651
DO  - 10.2298/ABS1404645J
ER  - 
@article{
author = "Jovanović, Predrag and Puškaš, Nela and Stefanović, Bojana and Spasojević, Nataša and Dronjak, Slađana",
year = "2014",
abstract = "Social isolation induced a significant increase in resting heart rate and reduction in heart rate variability. Dysfunction of the intrinsic cardiac nervous system is implicated in the genesis of cardiovascular diseases. Previous evidence suggests that cardiac ganglia contain noradrenergic neurons. Thus, immunohistochemical expression of catecholamine-synthesizing enzyme tyrosine hydroxylase (TH) and vesicular monoamine transporter 2 (VMAT2) were analyzed, as well as the effects of social isolation stress on mRNA and protein levels of this enzyme and transporter in the intrinsic cardiac nervous system of adult rats. Our results indicate that cardiac ganglion neurons express TH and VMAT2 immunoreactivity. Chronic isolated stress of rats caused a decrease in TH mRNA and VMAT2 mRNA in the neurons of intrinsic cardiac ganglia. No significant alterations in the protein levels of TH and VMAT2 were observed in these neurons. These data indicate that the neurons of intrinsic cardiac ganglia express TH as well as VMAT2 but that social isolation stress does not change their protein levels.",
journal = "Archives of biological sciences",
title = "Immunohistochemical Detection and Gene Expression of Tyrosine Hydroxylase and Vesicular Monoamine Transporter Type 2 in Intrinsic Cardiac Ganglia of Socially Isolated Rats",
volume = "66",
number = "4",
pages = "1645-1651",
doi = "10.2298/ABS1404645J"
}
Jovanović, P., Puškaš, N., Stefanović, B., Spasojević, N.,& Dronjak, S.. (2014). Immunohistochemical Detection and Gene Expression of Tyrosine Hydroxylase and Vesicular Monoamine Transporter Type 2 in Intrinsic Cardiac Ganglia of Socially Isolated Rats. in Archives of biological sciences, 66(4), 1645-1651.
https://doi.org/10.2298/ABS1404645J
Jovanović P, Puškaš N, Stefanović B, Spasojević N, Dronjak S. Immunohistochemical Detection and Gene Expression of Tyrosine Hydroxylase and Vesicular Monoamine Transporter Type 2 in Intrinsic Cardiac Ganglia of Socially Isolated Rats. in Archives of biological sciences. 2014;66(4):1645-1651.
doi:10.2298/ABS1404645J .
Jovanović, Predrag, Puškaš, Nela, Stefanović, Bojana, Spasojević, Nataša, Dronjak, Slađana, "Immunohistochemical Detection and Gene Expression of Tyrosine Hydroxylase and Vesicular Monoamine Transporter Type 2 in Intrinsic Cardiac Ganglia of Socially Isolated Rats" in Archives of biological sciences, 66, no. 4 (2014):1645-1651,
https://doi.org/10.2298/ABS1404645J . .

Spectral analysis of thioacetamide-induced electroencephalographic changes in rats

Mladenovic, D.; Hrnčić, Dragan; Rašić-Marković, Aleksandra; Puškaš, Nela; Petrovic, S.; Stanojlović, Olivera

(2013)

TY  - JOUR
AU  - Mladenovic, D.
AU  - Hrnčić, Dragan
AU  - Rašić-Marković, Aleksandra
AU  - Puškaš, Nela
AU  - Petrovic, S.
AU  - Stanojlović, Olivera
PY  - 2013
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/5226
AB  - Thioacetamide (TAA) is widely used as a model of hepatic encephalopathy (HE). The aim of our study was to investigate the effects of TAA on electroencephalographic (EEG) changes in rats and to compare them with human HE. Male Wistar rats were divided into groups: (1) saline-treated group and (2) TAA-treated groups: TAA(300) (300 mg/kg), TAA(600) (600 mg/kg), and TAA(900) (900 mg/kg). Daily dose of TAA (300 mg/kg) was administered intraperitoneally once (TAA(300)), twice (TAA(600)), or thrice (TAA(900)) in subsequent days. EEG changes were recorded about 24 h after the last dose of TAA. Absolute and relative power density in alpha bands were significantly higher in TAA(300) versus control group. In TAA(300), absolute beta power density was higher and relative beta power density was lower versus control group. Absolute alpha, theta, delta, and relative theta power were significantly lower, while relative power in delta band was significantly higher in TAA(900) versus control group (p LT 0.01). In conclusion, decrease in EEG voltage with an increase in delta relative power, which correspond to the EEG manifestations of severe HE in humans, was observed in TAA(900) group. Electrical activity in TAA(300) group correlates with mild HE in humans.
T2  - Human and Experimental Toxicology
T1  - Spectral analysis of thioacetamide-induced electroencephalographic changes in rats
VL  - 32
IS  - 1
SP  - 90
EP  - 100
DO  - 10.1177/0960327112456312
ER  - 
@article{
author = "Mladenovic, D. and Hrnčić, Dragan and Rašić-Marković, Aleksandra and Puškaš, Nela and Petrovic, S. and Stanojlović, Olivera",
year = "2013",
abstract = "Thioacetamide (TAA) is widely used as a model of hepatic encephalopathy (HE). The aim of our study was to investigate the effects of TAA on electroencephalographic (EEG) changes in rats and to compare them with human HE. Male Wistar rats were divided into groups: (1) saline-treated group and (2) TAA-treated groups: TAA(300) (300 mg/kg), TAA(600) (600 mg/kg), and TAA(900) (900 mg/kg). Daily dose of TAA (300 mg/kg) was administered intraperitoneally once (TAA(300)), twice (TAA(600)), or thrice (TAA(900)) in subsequent days. EEG changes were recorded about 24 h after the last dose of TAA. Absolute and relative power density in alpha bands were significantly higher in TAA(300) versus control group. In TAA(300), absolute beta power density was higher and relative beta power density was lower versus control group. Absolute alpha, theta, delta, and relative theta power were significantly lower, while relative power in delta band was significantly higher in TAA(900) versus control group (p LT 0.01). In conclusion, decrease in EEG voltage with an increase in delta relative power, which correspond to the EEG manifestations of severe HE in humans, was observed in TAA(900) group. Electrical activity in TAA(300) group correlates with mild HE in humans.",
journal = "Human and Experimental Toxicology",
title = "Spectral analysis of thioacetamide-induced electroencephalographic changes in rats",
volume = "32",
number = "1",
pages = "90-100",
doi = "10.1177/0960327112456312"
}
Mladenovic, D., Hrnčić, D., Rašić-Marković, A., Puškaš, N., Petrovic, S.,& Stanojlović, O.. (2013). Spectral analysis of thioacetamide-induced electroencephalographic changes in rats. in Human and Experimental Toxicology, 32(1), 90-100.
https://doi.org/10.1177/0960327112456312
Mladenovic D, Hrnčić D, Rašić-Marković A, Puškaš N, Petrovic S, Stanojlović O. Spectral analysis of thioacetamide-induced electroencephalographic changes in rats. in Human and Experimental Toxicology. 2013;32(1):90-100.
doi:10.1177/0960327112456312 .
Mladenovic, D., Hrnčić, Dragan, Rašić-Marković, Aleksandra, Puškaš, Nela, Petrovic, S., Stanojlović, Olivera, "Spectral analysis of thioacetamide-induced electroencephalographic changes in rats" in Human and Experimental Toxicology, 32, no. 1 (2013):90-100,
https://doi.org/10.1177/0960327112456312 . .
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In Vivo Mri Biocompatibility Evaluation of Functionalized Carbon Fibers in Reaction with Soft Tissues

Prokic, B. B.; Bačić, Goran; Prokic, B.; Kalijadis, Ana; Todorović, Vera; Puškaš, Nela; Vidojevic, D.; Lausevic, Mila; Laušević, Zoran

(2012)

TY  - JOUR
AU  - Prokic, B. B.
AU  - Bačić, Goran
AU  - Prokic, B.
AU  - Kalijadis, Ana
AU  - Todorović, Vera
AU  - Puškaš, Nela
AU  - Vidojevic, D.
AU  - Lausevic, Mila
AU  - Laušević, Zoran
PY  - 2012
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/5251
AB  - In modern medicine implants are very important and so is their design and choice of materials. Almost equally important is the choice of imaging technique used to in vivo monitor their fate and biocompatibility. The aim of this study was to evaluate the ability of magnetic resonance imaging (MRI) in monitoring the biocompatibility of two newly designed carbon fibers. We have analyzed the interaction of surface functionalized carbon fibers (basic and acidic) with muscle and subcutaneous tissues of rabbits. MRI techniques showed to be useful in longitudinal monitoring of the surrounding tissues, assessment of biocompatibility of new implants, and in the distinction of in vivo surgical edema from inflammation. Histopathology confirmed MRI results, thus showing that MRI has a great potential for in vivo studies of such materials.
T2  - Acta Veterinaria, Beograd
T1  - In Vivo Mri Biocompatibility Evaluation of Functionalized Carbon Fibers in Reaction with Soft Tissues
VL  - 62
IS  - 5-6
SP  - 683
EP  - 696
DO  - 10.2298/AVB1206683P
ER  - 
@article{
author = "Prokic, B. B. and Bačić, Goran and Prokic, B. and Kalijadis, Ana and Todorović, Vera and Puškaš, Nela and Vidojevic, D. and Lausevic, Mila and Laušević, Zoran",
year = "2012",
abstract = "In modern medicine implants are very important and so is their design and choice of materials. Almost equally important is the choice of imaging technique used to in vivo monitor their fate and biocompatibility. The aim of this study was to evaluate the ability of magnetic resonance imaging (MRI) in monitoring the biocompatibility of two newly designed carbon fibers. We have analyzed the interaction of surface functionalized carbon fibers (basic and acidic) with muscle and subcutaneous tissues of rabbits. MRI techniques showed to be useful in longitudinal monitoring of the surrounding tissues, assessment of biocompatibility of new implants, and in the distinction of in vivo surgical edema from inflammation. Histopathology confirmed MRI results, thus showing that MRI has a great potential for in vivo studies of such materials.",
journal = "Acta Veterinaria, Beograd",
title = "In Vivo Mri Biocompatibility Evaluation of Functionalized Carbon Fibers in Reaction with Soft Tissues",
volume = "62",
number = "5-6",
pages = "683-696",
doi = "10.2298/AVB1206683P"
}
Prokic, B. B., Bačić, G., Prokic, B., Kalijadis, A., Todorović, V., Puškaš, N., Vidojevic, D., Lausevic, M.,& Laušević, Z.. (2012). In Vivo Mri Biocompatibility Evaluation of Functionalized Carbon Fibers in Reaction with Soft Tissues. in Acta Veterinaria, Beograd, 62(5-6), 683-696.
https://doi.org/10.2298/AVB1206683P
Prokic BB, Bačić G, Prokic B, Kalijadis A, Todorović V, Puškaš N, Vidojevic D, Lausevic M, Laušević Z. In Vivo Mri Biocompatibility Evaluation of Functionalized Carbon Fibers in Reaction with Soft Tissues. in Acta Veterinaria, Beograd. 2012;62(5-6):683-696.
doi:10.2298/AVB1206683P .
Prokic, B. B., Bačić, Goran, Prokic, B., Kalijadis, Ana, Todorović, Vera, Puškaš, Nela, Vidojevic, D., Lausevic, Mila, Laušević, Zoran, "In Vivo Mri Biocompatibility Evaluation of Functionalized Carbon Fibers in Reaction with Soft Tissues" in Acta Veterinaria, Beograd, 62, no. 5-6 (2012):683-696,
https://doi.org/10.2298/AVB1206683P . .
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