TY  - JOUR
AU  - Radulović, Niko S.
AU  - Zlatković, Dragan B.
AU  - Ranđelović, Pavle J.
AU  - Stojanović, Nikola M.
AU  - Novaković, Slađana B.
AU  - Akhlaghi, Hashem
PY  - 2013
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/5766
AB  - Ferula ovina (Boiss.) Boiss. is a traditional Iranian flavoring agent used as an ingredient of spices and condiments. Methods and results: GC-MS analyses of F. ovina aerial parts essential oil revealed the presence of a number of rare aromatic esters of monoterpenic alcohols. The structures of these esters were corroborated by synthesis, and one of them, bornyl 4-methoxybenzoate, turned out to be a new natural compound. The antinociceptive activities of the oil and the new ester were assessed in mice using several different laboratory models. The oil exerted strong peripheral and moderate central analgesic activities. Surprisingly, mice treated with bornyl 4-methoxybenzoate had an increased sensitivity to the noxious stimulus compared to that of the control group. A dynamic hot plate test was used to demonstrate that bornyl 4-methoxybenzoate induces hyperalgesia and not allodynia. Conclusion: Essential oil constituents impart this spice with both antinociceptive and hyperalgesic potentially flavor-related properties.
T2  - Food and Function
T1  - Chemistry of spices: bornyl 4-methoxybenzoate from Ferula ovina (Boiss.) Boiss. (Apiaceae) induces hyperalgesia in mice
VL  - 4
IS  - 12
SP  - 1751
EP  - 1758
DO  - 10.1039/c3fo60319a
ER  - 

@article{
author = "Radulović, Niko S. and Zlatković, Dragan B. and Ranđelović, Pavle J. and Stojanović, Nikola M. and Novaković, Slađana B. and Akhlaghi, Hashem",
year = "2013",
abstract = "Ferula ovina (Boiss.) Boiss. is a traditional Iranian flavoring agent used as an ingredient of spices and condiments. Methods and results: GC-MS analyses of F. ovina aerial parts essential oil revealed the presence of a number of rare aromatic esters of monoterpenic alcohols. The structures of these esters were corroborated by synthesis, and one of them, bornyl 4-methoxybenzoate, turned out to be a new natural compound. The antinociceptive activities of the oil and the new ester were assessed in mice using several different laboratory models. The oil exerted strong peripheral and moderate central analgesic activities. Surprisingly, mice treated with bornyl 4-methoxybenzoate had an increased sensitivity to the noxious stimulus compared to that of the control group. A dynamic hot plate test was used to demonstrate that bornyl 4-methoxybenzoate induces hyperalgesia and not allodynia. Conclusion: Essential oil constituents impart this spice with both antinociceptive and hyperalgesic potentially flavor-related properties.",
journal = "Food and Function",
title = "Chemistry of spices: bornyl 4-methoxybenzoate from Ferula ovina (Boiss.) Boiss. (Apiaceae) induces hyperalgesia in mice",
volume = "4",
number = "12",
pages = "1751-1758",
doi = "10.1039/c3fo60319a"
}

Radulović, N. S., Zlatković, D. B., Ranđelović, P. J., Stojanović, N. M., Novaković, S. B.,& Akhlaghi, H.. (2013). Chemistry of spices: bornyl 4-methoxybenzoate from Ferula ovina (Boiss.) Boiss. (Apiaceae) induces hyperalgesia in mice. in Food and Function, 4(12), 1751-1758.
https://doi.org/10.1039/c3fo60319a

Radulović NS, Zlatković DB, Ranđelović PJ, Stojanović NM, Novaković SB, Akhlaghi H. Chemistry of spices: bornyl 4-methoxybenzoate from Ferula ovina (Boiss.) Boiss. (Apiaceae) induces hyperalgesia in mice. in Food and Function. 2013;4(12):1751-1758.
doi:10.1039/c3fo60319a .

Radulović, Niko S., Zlatković, Dragan B., Ranđelović, Pavle J., Stojanović, Nikola M., Novaković, Slađana B., Akhlaghi, Hashem, "Chemistry of spices: bornyl 4-methoxybenzoate from Ferula ovina (Boiss.) Boiss. (Apiaceae) induces hyperalgesia in mice" in Food and Function, 4, no. 12 (2013):1751-1758,
https://doi.org/10.1039/c3fo60319a . .