TY  - JOUR
AU  - Djordjevic-Markovic, R
AU  - Radić, Olivera
AU  - Jelic, V
AU  - Radojčić, Marija
AU  - Rapic-Otrin, V
AU  - Ruždijić, Sabera
AU  - Krstić-Demonacos, Marija
AU  - Kanazir, Selma
AU  - Kanazir, Selma
PY  - 1999
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/2305
AB  - The role of the glucocorticoid receptor (GR) in senescence was studied in rats of increasing age. Statistically significant changes in the number of GRs from rat liver were detected, whereas the affinity for the ligand triamcinolone acetonide (TA) did not change with increasing age, and was in the range of 1-2 nM. In all cases the number of receptors was lower in rats treated with hormone in vivo relative to untreated animals. In addition, we have found changes in GR activation, as measured by the binding to DNA cellulose in the mentioned age groups. Furthermore, expression of the glucocorticoid hormone (GH)-inducible gene, tyrosine amino transferase (TAT) also showed age-related alterations. We conclude that receptor function shows oscillatory changes during ageing. In addition, response to GH generally declines towards the older age. This. specific periodicity in functional characteristics of the GR may reconcile conflicting results about the receptor number and properties during the ageing process, and marks particular age at which individual organism shows the highest or the lowest sensitivity to the actions of GH. (C) 1999 Elsevier Science Inc. All rights reserved.
T2  - Experimental Gerontology
T1  - Glucocorticoid receptors in ageing rats
VL  - 34
IS  - 8
SP  - 971
EP  - 982
DO  - 10.1016/S0531-5565(99)00067-4
ER  - 

@article{
author = "Djordjevic-Markovic, R and Radić, Olivera and Jelic, V and Radojčić, Marija and Rapic-Otrin, V and Ruždijić, Sabera and Krstić-Demonacos, Marija and Kanazir, Selma and Kanazir, Selma",
year = "1999",
abstract = "The role of the glucocorticoid receptor (GR) in senescence was studied in rats of increasing age. Statistically significant changes in the number of GRs from rat liver were detected, whereas the affinity for the ligand triamcinolone acetonide (TA) did not change with increasing age, and was in the range of 1-2 nM. In all cases the number of receptors was lower in rats treated with hormone in vivo relative to untreated animals. In addition, we have found changes in GR activation, as measured by the binding to DNA cellulose in the mentioned age groups. Furthermore, expression of the glucocorticoid hormone (GH)-inducible gene, tyrosine amino transferase (TAT) also showed age-related alterations. We conclude that receptor function shows oscillatory changes during ageing. In addition, response to GH generally declines towards the older age. This. specific periodicity in functional characteristics of the GR may reconcile conflicting results about the receptor number and properties during the ageing process, and marks particular age at which individual organism shows the highest or the lowest sensitivity to the actions of GH. (C) 1999 Elsevier Science Inc. All rights reserved.",
journal = "Experimental Gerontology",
title = "Glucocorticoid receptors in ageing rats",
volume = "34",
number = "8",
pages = "971-982",
doi = "10.1016/S0531-5565(99)00067-4"
}

Djordjevic-Markovic, R., Radić, O., Jelic, V., Radojčić, M., Rapic-Otrin, V., Ruždijić, S., Krstić-Demonacos, M., Kanazir, S.,& Kanazir, S.. (1999). Glucocorticoid receptors in ageing rats. in Experimental Gerontology, 34(8), 971-982.
https://doi.org/10.1016/S0531-5565(99)00067-4

Djordjevic-Markovic R, Radić O, Jelic V, Radojčić M, Rapic-Otrin V, Ruždijić S, Krstić-Demonacos M, Kanazir S, Kanazir S. Glucocorticoid receptors in ageing rats. in Experimental Gerontology. 1999;34(8):971-982.
doi:10.1016/S0531-5565(99)00067-4 .

Djordjevic-Markovic, R, Radić, Olivera, Jelic, V, Radojčić, Marija, Rapic-Otrin, V, Ruždijić, Sabera, Krstić-Demonacos, Marija, Kanazir, Selma, Kanazir, Selma, "Glucocorticoid receptors in ageing rats" in Experimental Gerontology, 34, no. 8 (1999):971-982,
https://doi.org/10.1016/S0531-5565(99)00067-4 . .