TY  - JOUR
AU  - Jaksic, Emilija
AU  - Artiko, Vera
AU  - Beatovic, Slobodanka
AU  - Đokić, Divna Đ.
AU  - Janković, Drina
AU  - Saranovic, Dragana Sobic
AU  - Han, Ruben
AU  - Obradović, Vladimir
PY  - 2009
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/3605
AB  - Objective Tc-99m-p-aminohippuric acid (PAH) is a new radiopharmaceutical rapidly secreted by the kidneys in a manner consistent with tubular secretion. A comparative study of renal scintigraphy and clearance with Tc-99m-PAH, diethylene triamine pentaacetic acid (DTPA) and mercaptoacetyltriglycine (MAG(3)) was performed. Methods (TC)-T-99m-PAH was prepared from a lyophilized kit by addition of sodium pertechnetate in the presence of DTPA. Ten healthy individuals were injected with 110 MBq of Tc-99m-PAH. A dynamic study was repeated with Tc-99m-DTPA and Tc-99m-MAG(3) several days later, after a 1-day interval. Clearance measurements were performed in five individuals. Results The mean values of time-to-peak activity (T-max) and the time from peak to 50% of peak activity (T-1/2) for Tc-99m-PAH (3.6 +/- 0.9 and 6.9 +/- 2.7 min, respectively) and Tc-99m-MAG, (3.5 +/- 0.8 and 6.8 +/- 2.1 respectively) were significantly lower in comparison with those of Tc-99m-DTPA (4.9 +/- 1.7 and 11.7 +/- 1.9 min, respectively). The mean value of Tc-99m-PAH clearance (186.9 +/- 12.2 ml/min) was significantly lower in comparison with MAG(3) clearance (303.9 +/- 19.5 ml/min) and significantly higher than DTPA clearance (85.0 +/- 24.1 ml/min). Conclusion Our preliminary results indicate the potential usefulness of Tc-99m-PAH for routine renal scintigraphy. Owing to its fast kinetics, excretion and high-quality images, it could be a suitable for Tc-99m-DTPA. Tc-99m-PAH clearance values, however, were significantly lower than those of MAG(3), and could not be used for the estimation of renal plasma flow. Nucl Med Commun 30:76-81 (C) 2009 Wolters Kluwer Health vertical bar Lippincott Williams and Wilkins.
T2  - Nuclear Medicine Communications
T1  - Clinical investigations of Tc-99m-p-aminohippuric acid as a new renal agent
VL  - 30
IS  - 1
SP  - 76
EP  - 81
DO  - 10.1097/MNM.0b013e328314b8bc
ER  - 

@article{
author = "Jaksic, Emilija and Artiko, Vera and Beatovic, Slobodanka and Đokić, Divna Đ. and Janković, Drina and Saranovic, Dragana Sobic and Han, Ruben and Obradović, Vladimir",
year = "2009",
abstract = "Objective Tc-99m-p-aminohippuric acid (PAH) is a new radiopharmaceutical rapidly secreted by the kidneys in a manner consistent with tubular secretion. A comparative study of renal scintigraphy and clearance with Tc-99m-PAH, diethylene triamine pentaacetic acid (DTPA) and mercaptoacetyltriglycine (MAG(3)) was performed. Methods (TC)-T-99m-PAH was prepared from a lyophilized kit by addition of sodium pertechnetate in the presence of DTPA. Ten healthy individuals were injected with 110 MBq of Tc-99m-PAH. A dynamic study was repeated with Tc-99m-DTPA and Tc-99m-MAG(3) several days later, after a 1-day interval. Clearance measurements were performed in five individuals. Results The mean values of time-to-peak activity (T-max) and the time from peak to 50% of peak activity (T-1/2) for Tc-99m-PAH (3.6 +/- 0.9 and 6.9 +/- 2.7 min, respectively) and Tc-99m-MAG, (3.5 +/- 0.8 and 6.8 +/- 2.1 respectively) were significantly lower in comparison with those of Tc-99m-DTPA (4.9 +/- 1.7 and 11.7 +/- 1.9 min, respectively). The mean value of Tc-99m-PAH clearance (186.9 +/- 12.2 ml/min) was significantly lower in comparison with MAG(3) clearance (303.9 +/- 19.5 ml/min) and significantly higher than DTPA clearance (85.0 +/- 24.1 ml/min). Conclusion Our preliminary results indicate the potential usefulness of Tc-99m-PAH for routine renal scintigraphy. Owing to its fast kinetics, excretion and high-quality images, it could be a suitable for Tc-99m-DTPA. Tc-99m-PAH clearance values, however, were significantly lower than those of MAG(3), and could not be used for the estimation of renal plasma flow. Nucl Med Commun 30:76-81 (C) 2009 Wolters Kluwer Health vertical bar Lippincott Williams and Wilkins.",
journal = "Nuclear Medicine Communications",
title = "Clinical investigations of Tc-99m-p-aminohippuric acid as a new renal agent",
volume = "30",
number = "1",
pages = "76-81",
doi = "10.1097/MNM.0b013e328314b8bc"
}

Jaksic, E., Artiko, V., Beatovic, S., Đokić, D. Đ., Janković, D., Saranovic, D. S., Han, R.,& Obradović, V.. (2009). Clinical investigations of Tc-99m-p-aminohippuric acid as a new renal agent. in Nuclear Medicine Communications, 30(1), 76-81.
https://doi.org/10.1097/MNM.0b013e328314b8bc

Jaksic E, Artiko V, Beatovic S, Đokić DĐ, Janković D, Saranovic DS, Han R, Obradović V. Clinical investigations of Tc-99m-p-aminohippuric acid as a new renal agent. in Nuclear Medicine Communications. 2009;30(1):76-81.
doi:10.1097/MNM.0b013e328314b8bc .

Jaksic, Emilija, Artiko, Vera, Beatovic, Slobodanka, Đokić, Divna Đ., Janković, Drina, Saranovic, Dragana Sobic, Han, Ruben, Obradović, Vladimir, "Clinical investigations of Tc-99m-p-aminohippuric acid as a new renal agent" in Nuclear Medicine Communications, 30, no. 1 (2009):76-81,
https://doi.org/10.1097/MNM.0b013e328314b8bc . .