Savić, Aleksandar

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orcid::0000-0003-4990-7829
  • Savić, Aleksandar (6)
Projects

Author's Bibliography

Thermomechanical behavior of bio-fiber composite thermal insulation panels

Savić, Aleksandar; Antonijević, Dragi; Jelić, Ivana; Zakić, Dimitrije

(2020)

TY  - JOUR
AU  - Savić, Aleksandar
AU  - Antonijević, Dragi
AU  - Jelić, Ivana
AU  - Zakić, Dimitrije
PY  - 2020
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/9669
AB  - The thermomechanical properties of the bio-fiber composite, as material for the production of thermal insulation panels, were evaluated. The observed mixtures were composed of Miscanthus × giganteus bio-fibers, mineral binders (cement or lime), pozzolanic materials (zeolite and fly ash), and water. The favorable heat transfer behavior of composites based on Miscanthus × giganteus bio-fibers was already affirmed by literature data of similar natural bio-fiber materials, the author’s previous experimental results, and consideration of dynamic heat transfer processes in the insulated outer wall exposed to variable ambient conditions. The experimental assessment was focused on the bearing capacity (i.e. compressive and flexural strength), water absorption, and durability (i.e. resistance to freeze-thaw and carbonation), because there is scarce literature data regarding these properties, whose thorough understanding and systematization are highly important for a wider application of biomass-based thermal insulation materials. The obtained results were evaluated through the comparison to published data from similar bio-based thermal insulations, as well as from conventional thermo-insulation materials such as polystyrene and stone or glass wool.
T2  - Energy and Buildings
T2  - Energy and BuildingsEnergy and Buildings
T1  - Thermomechanical behavior of bio-fiber composite thermal insulation panels
VL  - 229
SP  - 110511
DO  - 10.1016/j.enbuild.2020.110511
ER  - 
@article{
author = "Savić, Aleksandar and Antonijević, Dragi and Jelić, Ivana and Zakić, Dimitrije",
year = "2020",
abstract = "The thermomechanical properties of the bio-fiber composite, as material for the production of thermal insulation panels, were evaluated. The observed mixtures were composed of Miscanthus × giganteus bio-fibers, mineral binders (cement or lime), pozzolanic materials (zeolite and fly ash), and water. The favorable heat transfer behavior of composites based on Miscanthus × giganteus bio-fibers was already affirmed by literature data of similar natural bio-fiber materials, the author’s previous experimental results, and consideration of dynamic heat transfer processes in the insulated outer wall exposed to variable ambient conditions. The experimental assessment was focused on the bearing capacity (i.e. compressive and flexural strength), water absorption, and durability (i.e. resistance to freeze-thaw and carbonation), because there is scarce literature data regarding these properties, whose thorough understanding and systematization are highly important for a wider application of biomass-based thermal insulation materials. The obtained results were evaluated through the comparison to published data from similar bio-based thermal insulations, as well as from conventional thermo-insulation materials such as polystyrene and stone or glass wool.",
journal = "Energy and Buildings, Energy and BuildingsEnergy and Buildings",
title = "Thermomechanical behavior of bio-fiber composite thermal insulation panels",
volume = "229",
pages = "110511",
doi = "10.1016/j.enbuild.2020.110511"
}
Savić, A., Antonijević, D., Jelić, I.,& Zakić, D.. (2020). Thermomechanical behavior of bio-fiber composite thermal insulation panels. in Energy and Buildings, 229, 110511.
https://doi.org/10.1016/j.enbuild.2020.110511
Savić A, Antonijević D, Jelić I, Zakić D. Thermomechanical behavior of bio-fiber composite thermal insulation panels. in Energy and Buildings. 2020;229:110511.
doi:10.1016/j.enbuild.2020.110511 .
Savić, Aleksandar, Antonijević, Dragi, Jelić, Ivana, Zakić, Dimitrije, "Thermomechanical behavior of bio-fiber composite thermal insulation panels" in Energy and Buildings, 229 (2020):110511,
https://doi.org/10.1016/j.enbuild.2020.110511 . .
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An insight into chemical composition and biological activity of Montenegrin Vranac red wine

Đorđević, Neda O.; Novaković, M.; Pejin, Boris; Živković, Marijana B.; Savić, Aleksandar; Mutić, Jelena J.; Tegevic, V.

(2018)

TY  - JOUR
AU  - Đorđević, Neda O.
AU  - Novaković, M.
AU  - Pejin, Boris
AU  - Živković, Marijana B.
AU  - Savić, Aleksandar
AU  - Mutić, Jelena J.
AU  - Tegevic, V.
PY  - 2018
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/1923
AB  - This study aimed to describe quality and potential health benefits of three Vranac wines obtained from new grape clones (CI, CII and CIII) recently developed and recognised. In this aim, their phenolic profiles, anti-2,2-Diphenyl-1-picrylhydrazyl (DPPH) radical activities along with metal compositions were analyzed. Compared with the commercial one, CII and CIII Vranac wines were found to contain both higher contents of total phenolics, flavonoids and monomeric anthocyanins as well as anti-DPPH radical activities. The most abundant phenolics were gallic acid (8.88-16.36 mg/L), catechin (12.42-24.35 mg/L) and epicatechin (4.30-7.79 mg/L). Finally, the metal content of all the analyzed samples was within the toxicological safety limits. Taken all together, Montenegrin Vranac wines represent a rich source of both phenolics and minerals exhibiting promising antioxidant potential. CII and CIII wines can be considered for commercialising due to their high amounts of gallic acid, catechin and epicatechin, significant K/Na ratios and favourable contents of essential metals making them products with health added values.
T2  - Scientia Horticulturae
T1  - An insight into chemical composition and biological activity of Montenegrin Vranac red wine
VL  - 230
SP  - 142
EP  - 148
DO  - 10.1016/j.scienta.2017.11.033
ER  - 
@article{
author = "Đorđević, Neda O. and Novaković, M. and Pejin, Boris and Živković, Marijana B. and Savić, Aleksandar and Mutić, Jelena J. and Tegevic, V.",
year = "2018",
abstract = "This study aimed to describe quality and potential health benefits of three Vranac wines obtained from new grape clones (CI, CII and CIII) recently developed and recognised. In this aim, their phenolic profiles, anti-2,2-Diphenyl-1-picrylhydrazyl (DPPH) radical activities along with metal compositions were analyzed. Compared with the commercial one, CII and CIII Vranac wines were found to contain both higher contents of total phenolics, flavonoids and monomeric anthocyanins as well as anti-DPPH radical activities. The most abundant phenolics were gallic acid (8.88-16.36 mg/L), catechin (12.42-24.35 mg/L) and epicatechin (4.30-7.79 mg/L). Finally, the metal content of all the analyzed samples was within the toxicological safety limits. Taken all together, Montenegrin Vranac wines represent a rich source of both phenolics and minerals exhibiting promising antioxidant potential. CII and CIII wines can be considered for commercialising due to their high amounts of gallic acid, catechin and epicatechin, significant K/Na ratios and favourable contents of essential metals making them products with health added values.",
journal = "Scientia Horticulturae",
title = "An insight into chemical composition and biological activity of Montenegrin Vranac red wine",
volume = "230",
pages = "142-148",
doi = "10.1016/j.scienta.2017.11.033"
}
Đorđević, N. O., Novaković, M., Pejin, B., Živković, M. B., Savić, A., Mutić, J. J.,& Tegevic, V.. (2018). An insight into chemical composition and biological activity of Montenegrin Vranac red wine. in Scientia Horticulturae, 230, 142-148.
https://doi.org/10.1016/j.scienta.2017.11.033
Đorđević NO, Novaković M, Pejin B, Živković MB, Savić A, Mutić JJ, Tegevic V. An insight into chemical composition and biological activity of Montenegrin Vranac red wine. in Scientia Horticulturae. 2018;230:142-148.
doi:10.1016/j.scienta.2017.11.033 .
Đorđević, Neda O., Novaković, M., Pejin, Boris, Živković, Marijana B., Savić, Aleksandar, Mutić, Jelena J., Tegevic, V., "An insight into chemical composition and biological activity of Montenegrin Vranac red wine" in Scientia Horticulturae, 230 (2018):142-148,
https://doi.org/10.1016/j.scienta.2017.11.033 . .
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New ruthenium(II) bipyridyl complex: Synthesis, crystal structure and cytotoxicity

Baroud, Afya A.; Mihajlović-Lalić, Ljiljana E.; Stanković, Dalibor M.; Kajzerberger, Marijana; Van Hecke, Kristof; Grgurić-Šipka, Sanja; Savić, Aleksandar

(2017)

TY  - JOUR
AU  - Baroud, Afya A.
AU  - Mihajlović-Lalić, Ljiljana E.
AU  - Stanković, Dalibor M.
AU  - Kajzerberger, Marijana
AU  - Van Hecke, Kristof
AU  - Grgurić-Šipka, Sanja
AU  - Savić, Aleksandar
PY  - 2017
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/1569
AB  - A new Ru(II) bipyridyl complex with O-4-hydrogenpyridine-2,4-dicarboxylate was synthesized and characterized by IR, NMR and mass spectrometry, X-ray diffraction analysis and elemental analysis. The electrochemical characteristics of the complex were investigated by cyclic voltammetry, revealing Ru(II)/Ru(III) electron transfer in the positive range of potentials. On the opposite potential side, multiple partially reversible peaks were dominant, representing subsequent reductions of the bulky bipyridyl moiety. The cytotoxic activity of the complex was tested in two human cancer cell lines: A549 (lung cancer) and K562 (leukemia) as well as non-tumor MRC-5 cells, by MTT assays. The IC50 values were GT 300 and 177.63+/-2.28 mu M for the A549 and K562 cells, respectively.
T2  - Journal of the Serbian Chemical Society
T1  - New ruthenium(II) bipyridyl complex: Synthesis, crystal structure and cytotoxicity
VL  - 82
IS  - 3
SP  - 267
EP  - 275
DO  - 10.2298/JSC170109025B
ER  - 
@article{
author = "Baroud, Afya A. and Mihajlović-Lalić, Ljiljana E. and Stanković, Dalibor M. and Kajzerberger, Marijana and Van Hecke, Kristof and Grgurić-Šipka, Sanja and Savić, Aleksandar",
year = "2017",
abstract = "A new Ru(II) bipyridyl complex with O-4-hydrogenpyridine-2,4-dicarboxylate was synthesized and characterized by IR, NMR and mass spectrometry, X-ray diffraction analysis and elemental analysis. The electrochemical characteristics of the complex were investigated by cyclic voltammetry, revealing Ru(II)/Ru(III) electron transfer in the positive range of potentials. On the opposite potential side, multiple partially reversible peaks were dominant, representing subsequent reductions of the bulky bipyridyl moiety. The cytotoxic activity of the complex was tested in two human cancer cell lines: A549 (lung cancer) and K562 (leukemia) as well as non-tumor MRC-5 cells, by MTT assays. The IC50 values were GT 300 and 177.63+/-2.28 mu M for the A549 and K562 cells, respectively.",
journal = "Journal of the Serbian Chemical Society",
title = "New ruthenium(II) bipyridyl complex: Synthesis, crystal structure and cytotoxicity",
volume = "82",
number = "3",
pages = "267-275",
doi = "10.2298/JSC170109025B"
}
Baroud, A. A., Mihajlović-Lalić, L. E., Stanković, D. M., Kajzerberger, M., Van Hecke, K., Grgurić-Šipka, S.,& Savić, A.. (2017). New ruthenium(II) bipyridyl complex: Synthesis, crystal structure and cytotoxicity. in Journal of the Serbian Chemical Society, 82(3), 267-275.
https://doi.org/10.2298/JSC170109025B
Baroud AA, Mihajlović-Lalić LE, Stanković DM, Kajzerberger M, Van Hecke K, Grgurić-Šipka S, Savić A. New ruthenium(II) bipyridyl complex: Synthesis, crystal structure and cytotoxicity. in Journal of the Serbian Chemical Society. 2017;82(3):267-275.
doi:10.2298/JSC170109025B .
Baroud, Afya A., Mihajlović-Lalić, Ljiljana E., Stanković, Dalibor M., Kajzerberger, Marijana, Van Hecke, Kristof, Grgurić-Šipka, Sanja, Savić, Aleksandar, "New ruthenium(II) bipyridyl complex: Synthesis, crystal structure and cytotoxicity" in Journal of the Serbian Chemical Society, 82, no. 3 (2017):267-275,
https://doi.org/10.2298/JSC170109025B . .
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Ruthenium(II) bipyridine complexes: from synthesis and crystal structures to electrochemical and cytotoxicity investigation

Baroud, Afya A.; Mihajlović-Lalić, Ljiljana E.; Gligorijević, Nevenka N.; Aranđelović, Sandra; Stanković, Dalibor M.; Radulović, Siniša S.; Van Hecke, Kristof; Savić, Aleksandar; Grgurić-Šipka, Sanja

(2017)

TY  - JOUR
AU  - Baroud, Afya A.
AU  - Mihajlović-Lalić, Ljiljana E.
AU  - Gligorijević, Nevenka N.
AU  - Aranđelović, Sandra
AU  - Stanković, Dalibor M.
AU  - Radulović, Siniša S.
AU  - Van Hecke, Kristof
AU  - Savić, Aleksandar
AU  - Grgurić-Šipka, Sanja
PY  - 2017
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/1438
AB  - Complexes 1-4, [Ru(L)(bpy)(2)]PF6, where bpy=2,2-bipyridine; HL=3-methylpyridine-2-carboxylic acid (HL1), 6-methylpyridine-2-carboxylic acid (HL2), 5-bromopyridine-2-carboxylic acid (HL3) and 6-bromopyridine-2-carboxylic acid (HL4), were synthesized and characterized. The electrochemical character of the complexes was investigated by cyclic voltammetry revealing two reversible reduction waves in the negative range of potentials, most likely due to a reduction of the bipyridine moiety. Cytotoxicity studies by MTT assay for 72h of drug action revealed that 2-4 exhibited moderate activity in cervical human tumor cells (HeLa). Complex 2 exhibited low activity in colon cancer LS-174 cells (180 +/- 10), while all complexes were devoid of activity in lung cancer A549 and non-tumor MRC-5 cells, up to 200M. Combinational studies of the most active complex 2, with pharmacological modulators of cell redox status, L-buthionine-sulfoximine (L-BSO) or N-acetyl-L-cysteine (NAC), showed that when L-BSO potentiated, 2 induced a sub-G1 peak of the cell cycle in the HeLa cell line. UV-vis and cyclic voltammetry were performed in order to investigate the binding mode of 2 to DNA and suggested intercalation for the complex-DNA interaction. [GRAPHICS]
T2  - Journal of Coordination Chemistry
T1  - Ruthenium(II) bipyridine complexes: from synthesis and crystal structures to electrochemical and cytotoxicity investigation
VL  - 70
IS  - 5
SP  - 831
EP  - 847
DO  - 10.1080/00958972.2017.1282611
ER  - 
@article{
author = "Baroud, Afya A. and Mihajlović-Lalić, Ljiljana E. and Gligorijević, Nevenka N. and Aranđelović, Sandra and Stanković, Dalibor M. and Radulović, Siniša S. and Van Hecke, Kristof and Savić, Aleksandar and Grgurić-Šipka, Sanja",
year = "2017",
abstract = "Complexes 1-4, [Ru(L)(bpy)(2)]PF6, where bpy=2,2-bipyridine; HL=3-methylpyridine-2-carboxylic acid (HL1), 6-methylpyridine-2-carboxylic acid (HL2), 5-bromopyridine-2-carboxylic acid (HL3) and 6-bromopyridine-2-carboxylic acid (HL4), were synthesized and characterized. The electrochemical character of the complexes was investigated by cyclic voltammetry revealing two reversible reduction waves in the negative range of potentials, most likely due to a reduction of the bipyridine moiety. Cytotoxicity studies by MTT assay for 72h of drug action revealed that 2-4 exhibited moderate activity in cervical human tumor cells (HeLa). Complex 2 exhibited low activity in colon cancer LS-174 cells (180 +/- 10), while all complexes were devoid of activity in lung cancer A549 and non-tumor MRC-5 cells, up to 200M. Combinational studies of the most active complex 2, with pharmacological modulators of cell redox status, L-buthionine-sulfoximine (L-BSO) or N-acetyl-L-cysteine (NAC), showed that when L-BSO potentiated, 2 induced a sub-G1 peak of the cell cycle in the HeLa cell line. UV-vis and cyclic voltammetry were performed in order to investigate the binding mode of 2 to DNA and suggested intercalation for the complex-DNA interaction. [GRAPHICS]",
journal = "Journal of Coordination Chemistry",
title = "Ruthenium(II) bipyridine complexes: from synthesis and crystal structures to electrochemical and cytotoxicity investigation",
volume = "70",
number = "5",
pages = "831-847",
doi = "10.1080/00958972.2017.1282611"
}
Baroud, A. A., Mihajlović-Lalić, L. E., Gligorijević, N. N., Aranđelović, S., Stanković, D. M., Radulović, S. S., Van Hecke, K., Savić, A.,& Grgurić-Šipka, S.. (2017). Ruthenium(II) bipyridine complexes: from synthesis and crystal structures to electrochemical and cytotoxicity investigation. in Journal of Coordination Chemistry, 70(5), 831-847.
https://doi.org/10.1080/00958972.2017.1282611
Baroud AA, Mihajlović-Lalić LE, Gligorijević NN, Aranđelović S, Stanković DM, Radulović SS, Van Hecke K, Savić A, Grgurić-Šipka S. Ruthenium(II) bipyridine complexes: from synthesis and crystal structures to electrochemical and cytotoxicity investigation. in Journal of Coordination Chemistry. 2017;70(5):831-847.
doi:10.1080/00958972.2017.1282611 .
Baroud, Afya A., Mihajlović-Lalić, Ljiljana E., Gligorijević, Nevenka N., Aranđelović, Sandra, Stanković, Dalibor M., Radulović, Siniša S., Van Hecke, Kristof, Savić, Aleksandar, Grgurić-Šipka, Sanja, "Ruthenium(II) bipyridine complexes: from synthesis and crystal structures to electrochemical and cytotoxicity investigation" in Journal of Coordination Chemistry, 70, no. 5 (2017):831-847,
https://doi.org/10.1080/00958972.2017.1282611 . .
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Synthesis and biological evaluation of Tc-99m tricarbonyl complex of O,O -diethylethylenediamine-N,N -di-3-propanoate as potential tumour diagnostic agent

Lakić, Mladen; Sabo, Ljubica; Ristic, Slavica; Savić, Aleksandar; Petricevic, Sasa; Nikolić, Nadežda S.; Vukadinović, Aleksandar; Janković, Drina; Sabo, Tibor J.; Vranješ-Đurić, Sanja

(2016)

TY  - JOUR
AU  - Lakić, Mladen
AU  - Sabo, Ljubica
AU  - Ristic, Slavica
AU  - Savić, Aleksandar
AU  - Petricevic, Sasa
AU  - Nikolić, Nadežda S.
AU  - Vukadinović, Aleksandar
AU  - Janković, Drina
AU  - Sabo, Tibor J.
AU  - Vranješ-Đurić, Sanja
PY  - 2016
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/273
AB  - The extensive development of radiopharmaceuticals towards early tumour detection and treatment has increased the demand for new ligands with higher tumour selectivity. Research has been done on the potential of the novel O,O-diethylethylenediamine-N,N-di-3-propanoate (L) ligand as a radionuclide vehicle for tumour targeting. Under alkaline conditions, L hydrolyses and produces half ester ligand (L) and diacid ligand (L), with characteristic donor atom array N, N, O. Ligand L was successfully labelled with Tc-99m at pH=9 by coordination with the octahedral fac-[Tc-99m(CO)(3)(H2O)(3)](+) intermediate, forming the main radioproduct fac-[(TcL)-Tc-99m(CO)(3)] (Tc1). The Tc-99m complex showed a low lipophilic character (log P = 0.48) and low binding affinity to human serum albumin (2.51 +/- 0.48%). In vitro stability studies in saline and human plasma, as well as challenge studies with cysteine and histidine, revealed high stability of the complex during 24 h. Biodistribution studies of Tc1 in female C57BL/6 mice bearing B16/F1 melanoma metastases showed significant tumour uptake: 9.81 +/- 1.19% ID g(-1) in the liver, 5.87 +/- 0.54% ID g(-1) in the lungs and 3.17 +/- 0.33% ID g(-1) in the ovary at 30 min post-injection. Favourable physicochemical properties, satisfactory in vitro/in vivo stability and biodistribution profile in the experimental metastatic melanoma model indicate the possible application of the radiolabelled ligand in tumour diagnosis. Copyright (C) 2015 John Wiley and Sons, Ltd.
T2  - Applied Organometallic Chemistry
T1  - Synthesis and biological evaluation of Tc-99m tricarbonyl complex of O,O -diethylethylenediamine-N,N -di-3-propanoate as potential tumour diagnostic agent
VL  - 30
IS  - 2
SP  - 81
EP  - 88
DO  - 10.1002/aoc.3401
ER  - 
@article{
author = "Lakić, Mladen and Sabo, Ljubica and Ristic, Slavica and Savić, Aleksandar and Petricevic, Sasa and Nikolić, Nadežda S. and Vukadinović, Aleksandar and Janković, Drina and Sabo, Tibor J. and Vranješ-Đurić, Sanja",
year = "2016",
abstract = "The extensive development of radiopharmaceuticals towards early tumour detection and treatment has increased the demand for new ligands with higher tumour selectivity. Research has been done on the potential of the novel O,O-diethylethylenediamine-N,N-di-3-propanoate (L) ligand as a radionuclide vehicle for tumour targeting. Under alkaline conditions, L hydrolyses and produces half ester ligand (L) and diacid ligand (L), with characteristic donor atom array N, N, O. Ligand L was successfully labelled with Tc-99m at pH=9 by coordination with the octahedral fac-[Tc-99m(CO)(3)(H2O)(3)](+) intermediate, forming the main radioproduct fac-[(TcL)-Tc-99m(CO)(3)] (Tc1). The Tc-99m complex showed a low lipophilic character (log P = 0.48) and low binding affinity to human serum albumin (2.51 +/- 0.48%). In vitro stability studies in saline and human plasma, as well as challenge studies with cysteine and histidine, revealed high stability of the complex during 24 h. Biodistribution studies of Tc1 in female C57BL/6 mice bearing B16/F1 melanoma metastases showed significant tumour uptake: 9.81 +/- 1.19% ID g(-1) in the liver, 5.87 +/- 0.54% ID g(-1) in the lungs and 3.17 +/- 0.33% ID g(-1) in the ovary at 30 min post-injection. Favourable physicochemical properties, satisfactory in vitro/in vivo stability and biodistribution profile in the experimental metastatic melanoma model indicate the possible application of the radiolabelled ligand in tumour diagnosis. Copyright (C) 2015 John Wiley and Sons, Ltd.",
journal = "Applied Organometallic Chemistry",
title = "Synthesis and biological evaluation of Tc-99m tricarbonyl complex of O,O -diethylethylenediamine-N,N -di-3-propanoate as potential tumour diagnostic agent",
volume = "30",
number = "2",
pages = "81-88",
doi = "10.1002/aoc.3401"
}
Lakić, M., Sabo, L., Ristic, S., Savić, A., Petricevic, S., Nikolić, N. S., Vukadinović, A., Janković, D., Sabo, T. J.,& Vranješ-Đurić, S.. (2016). Synthesis and biological evaluation of Tc-99m tricarbonyl complex of O,O -diethylethylenediamine-N,N -di-3-propanoate as potential tumour diagnostic agent. in Applied Organometallic Chemistry, 30(2), 81-88.
https://doi.org/10.1002/aoc.3401
Lakić M, Sabo L, Ristic S, Savić A, Petricevic S, Nikolić NS, Vukadinović A, Janković D, Sabo TJ, Vranješ-Đurić S. Synthesis and biological evaluation of Tc-99m tricarbonyl complex of O,O -diethylethylenediamine-N,N -di-3-propanoate as potential tumour diagnostic agent. in Applied Organometallic Chemistry. 2016;30(2):81-88.
doi:10.1002/aoc.3401 .
Lakić, Mladen, Sabo, Ljubica, Ristic, Slavica, Savić, Aleksandar, Petricevic, Sasa, Nikolić, Nadežda S., Vukadinović, Aleksandar, Janković, Drina, Sabo, Tibor J., Vranješ-Đurić, Sanja, "Synthesis and biological evaluation of Tc-99m tricarbonyl complex of O,O -diethylethylenediamine-N,N -di-3-propanoate as potential tumour diagnostic agent" in Applied Organometallic Chemistry, 30, no. 2 (2016):81-88,
https://doi.org/10.1002/aoc.3401 . .
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Anti-cancer effects of cerium oxide nanoparticles and its intracellular redox activity

Pešić, Milica; Podolski-Renić, Ana; Stojković, Sonja; Matović, Branko; Zmejkoski, Danica; Kojić, Vesna; Bogdanović, Gordana; Pavicevic, Aleksandra; Mojovic, Milos; Savić, Aleksandar; Milenković, Ivana; Kalauzi, Aleksandar; Radotić, Ksenija

(2015)

TY  - JOUR
AU  - Pešić, Milica
AU  - Podolski-Renić, Ana
AU  - Stojković, Sonja
AU  - Matović, Branko
AU  - Zmejkoski, Danica
AU  - Kojić, Vesna
AU  - Bogdanović, Gordana
AU  - Pavicevic, Aleksandra
AU  - Mojovic, Milos
AU  - Savić, Aleksandar
AU  - Milenković, Ivana
AU  - Kalauzi, Aleksandar
AU  - Radotić, Ksenija
PY  - 2015
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/519
AB  - Data on medical applications of cerium oxide nanoparticles CeO2 (CONP) are promising, yet information regarding their action in cells is incomplete and there are conflicting reports about in vitro toxicity. Herein, we have studied cytotoxic effect of CONP in several cancer and normal cell lines and their potential to change intracellular redox status. The IC50 was achieved only in two of eight tested cell lines, melanoma 518A2 and colorectal adenocarcinoma HT-29. Self-propagating room temperature method was applied to produce CONP with an average crystalline size of 4 nm. The results confirmed presence of Ce3+ and O2- vacancies. The induction of cell death by CONP and the production of reactive oxygen species (ROS) were analyzed by flow-cytometry. Free radicals related antioxidant capacity of the cells was studied by the reduction of stable free radical TEMPONE using electron spin resonance spectroscopy. CONP showed low or moderate cytotoxicity in cancer cell lines: adenocarcinoma DLD1 and multi-drug resistant DLD1-TxR, non-small cell lung carcinoma NCI-H460 and multi-drug resistant NCI-H460/R, while normal cell lines (keratinocytes HaCaT, lung fetal fibroblasts MRC-5) were insensitive. The most sensitive were 518A2 melanoma and HT-29 colorectal adenocarcinoma cell lines, with the IC50 values being between 100 and 200 mu M. Decreased rate of TEMPONE reduction and increased production of certain ROS species (peroxynitrite and hydrogen peroxide anion) indicates that free radical metabolism, thus redox status was changed, and antioxidant capacity damaged in the CONP treated 518A2 and HT-29 cells. In conclusion, changes in intracellular redox status induced by CONP are partly attributed to the prooxidant activity of the nanoparticles. Further, ROS induced cell damages might eventually lead to the cell death. However, low inhibitory potential of CONP in the other human cell lines tested indicates that CONP may be safe for human usage in industry and medicine. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
T2  - Chemico-biological Interactions
T1  - Anti-cancer effects of cerium oxide nanoparticles and its intracellular redox activity
VL  - 232
SP  - 85
EP  - 93
DO  - 10.1016/j.cbi.2015.03.013
ER  - 
@article{
author = "Pešić, Milica and Podolski-Renić, Ana and Stojković, Sonja and Matović, Branko and Zmejkoski, Danica and Kojić, Vesna and Bogdanović, Gordana and Pavicevic, Aleksandra and Mojovic, Milos and Savić, Aleksandar and Milenković, Ivana and Kalauzi, Aleksandar and Radotić, Ksenija",
year = "2015",
abstract = "Data on medical applications of cerium oxide nanoparticles CeO2 (CONP) are promising, yet information regarding their action in cells is incomplete and there are conflicting reports about in vitro toxicity. Herein, we have studied cytotoxic effect of CONP in several cancer and normal cell lines and their potential to change intracellular redox status. The IC50 was achieved only in two of eight tested cell lines, melanoma 518A2 and colorectal adenocarcinoma HT-29. Self-propagating room temperature method was applied to produce CONP with an average crystalline size of 4 nm. The results confirmed presence of Ce3+ and O2- vacancies. The induction of cell death by CONP and the production of reactive oxygen species (ROS) were analyzed by flow-cytometry. Free radicals related antioxidant capacity of the cells was studied by the reduction of stable free radical TEMPONE using electron spin resonance spectroscopy. CONP showed low or moderate cytotoxicity in cancer cell lines: adenocarcinoma DLD1 and multi-drug resistant DLD1-TxR, non-small cell lung carcinoma NCI-H460 and multi-drug resistant NCI-H460/R, while normal cell lines (keratinocytes HaCaT, lung fetal fibroblasts MRC-5) were insensitive. The most sensitive were 518A2 melanoma and HT-29 colorectal adenocarcinoma cell lines, with the IC50 values being between 100 and 200 mu M. Decreased rate of TEMPONE reduction and increased production of certain ROS species (peroxynitrite and hydrogen peroxide anion) indicates that free radical metabolism, thus redox status was changed, and antioxidant capacity damaged in the CONP treated 518A2 and HT-29 cells. In conclusion, changes in intracellular redox status induced by CONP are partly attributed to the prooxidant activity of the nanoparticles. Further, ROS induced cell damages might eventually lead to the cell death. However, low inhibitory potential of CONP in the other human cell lines tested indicates that CONP may be safe for human usage in industry and medicine. (C) 2015 Elsevier Ireland Ltd. All rights reserved.",
journal = "Chemico-biological Interactions",
title = "Anti-cancer effects of cerium oxide nanoparticles and its intracellular redox activity",
volume = "232",
pages = "85-93",
doi = "10.1016/j.cbi.2015.03.013"
}
Pešić, M., Podolski-Renić, A., Stojković, S., Matović, B., Zmejkoski, D., Kojić, V., Bogdanović, G., Pavicevic, A., Mojovic, M., Savić, A., Milenković, I., Kalauzi, A.,& Radotić, K.. (2015). Anti-cancer effects of cerium oxide nanoparticles and its intracellular redox activity. in Chemico-biological Interactions, 232, 85-93.
https://doi.org/10.1016/j.cbi.2015.03.013
Pešić M, Podolski-Renić A, Stojković S, Matović B, Zmejkoski D, Kojić V, Bogdanović G, Pavicevic A, Mojovic M, Savić A, Milenković I, Kalauzi A, Radotić K. Anti-cancer effects of cerium oxide nanoparticles and its intracellular redox activity. in Chemico-biological Interactions. 2015;232:85-93.
doi:10.1016/j.cbi.2015.03.013 .
Pešić, Milica, Podolski-Renić, Ana, Stojković, Sonja, Matović, Branko, Zmejkoski, Danica, Kojić, Vesna, Bogdanović, Gordana, Pavicevic, Aleksandra, Mojovic, Milos, Savić, Aleksandar, Milenković, Ivana, Kalauzi, Aleksandar, Radotić, Ksenija, "Anti-cancer effects of cerium oxide nanoparticles and its intracellular redox activity" in Chemico-biological Interactions, 232 (2015):85-93,
https://doi.org/10.1016/j.cbi.2015.03.013 . .
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