TY  - JOUR
AU  - Veljković, Milena
AU  - Dopsaj, Violeta
AU  - Dopsaj, Milivoj
AU  - Branch, Donald R.
AU  - Veljković, Nevena V.
AU  - Sakarellos-Daitsiotis, Maria M.
AU  - Veljković, Veljko
AU  - Glišić, Sanja
AU  - Colombatti, Alfonso
PY  - 2011
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/4613
AB  - Background: There is convincing evidence from numerous clinical and epidemiological studies that physical activity can reduce the risk for breast and prostate cancer. The biological mechanisms underlying this phenomenon remain elusive. Herein we suggest a role for naturally produced antibodies reactive with the vasoactive intestinal peptide (VIP) in the suppression of breast and prostate cancer, which we believe could offer a possible molecular mechanism underlying control of these cancers by physical exercise. Methodology and Results: We found that sera from individuals having breast and prostate cancers have decreased titers of VIP natural antibodies as demonstrated by a lower reactivity against peptide NTM1, having similar informational and structural properties as VIP. In contrast, sera collected from elite athletes, exhibited titers of natural NTM1-reactive antibodies that are significantly increased, suggesting that physical activity boosts production of these antibodies. Significance: Presented results suggest that physical exercise stimulates production of natural anti-VIP antibodies and likely results in suppression of VIP. This, in turn, may play a protective role against breast and prostate cancers. Physical exercise should be further investigated as a potential tool in the treatment of these diseases.
T2  - PLOS One
T1  - Physical Activity and Natural Anti-VIP Antibodies: Potential Role in Breast and Prostate Cancer Therapy
VL  - 6
IS  - 11
DO  - 10.1371/journal.pone.0028304
ER  - 

@article{
author = "Veljković, Milena and Dopsaj, Violeta and Dopsaj, Milivoj and Branch, Donald R. and Veljković, Nevena V. and Sakarellos-Daitsiotis, Maria M. and Veljković, Veljko and Glišić, Sanja and Colombatti, Alfonso",
year = "2011",
abstract = "Background: There is convincing evidence from numerous clinical and epidemiological studies that physical activity can reduce the risk for breast and prostate cancer. The biological mechanisms underlying this phenomenon remain elusive. Herein we suggest a role for naturally produced antibodies reactive with the vasoactive intestinal peptide (VIP) in the suppression of breast and prostate cancer, which we believe could offer a possible molecular mechanism underlying control of these cancers by physical exercise. Methodology and Results: We found that sera from individuals having breast and prostate cancers have decreased titers of VIP natural antibodies as demonstrated by a lower reactivity against peptide NTM1, having similar informational and structural properties as VIP. In contrast, sera collected from elite athletes, exhibited titers of natural NTM1-reactive antibodies that are significantly increased, suggesting that physical activity boosts production of these antibodies. Significance: Presented results suggest that physical exercise stimulates production of natural anti-VIP antibodies and likely results in suppression of VIP. This, in turn, may play a protective role against breast and prostate cancers. Physical exercise should be further investigated as a potential tool in the treatment of these diseases.",
journal = "PLOS One",
title = "Physical Activity and Natural Anti-VIP Antibodies: Potential Role in Breast and Prostate Cancer Therapy",
volume = "6",
number = "11",
doi = "10.1371/journal.pone.0028304"
}

Veljković, M., Dopsaj, V., Dopsaj, M., Branch, D. R., Veljković, N. V., Sakarellos-Daitsiotis, M. M., Veljković, V., Glišić, S.,& Colombatti, A.. (2011). Physical Activity and Natural Anti-VIP Antibodies: Potential Role in Breast and Prostate Cancer Therapy. in PLOS One, 6(11).
https://doi.org/10.1371/journal.pone.0028304

Veljković M, Dopsaj V, Dopsaj M, Branch DR, Veljković NV, Sakarellos-Daitsiotis MM, Veljković V, Glišić S, Colombatti A. Physical Activity and Natural Anti-VIP Antibodies: Potential Role in Breast and Prostate Cancer Therapy. in PLOS One. 2011;6(11).
doi:10.1371/journal.pone.0028304 .

Veljković, Milena, Dopsaj, Violeta, Dopsaj, Milivoj, Branch, Donald R., Veljković, Nevena V., Sakarellos-Daitsiotis, Maria M., Veljković, Veljko, Glišić, Sanja, Colombatti, Alfonso, "Physical Activity and Natural Anti-VIP Antibodies: Potential Role in Breast and Prostate Cancer Therapy" in PLOS One, 6, no. 11 (2011),
https://doi.org/10.1371/journal.pone.0028304 . .

TY  - JOUR
AU  - Veljković, Milena
AU  - Branch, Donald R.
AU  - Dopsaj, Violeta
AU  - Veljković, Veljko
AU  - Veljković, Nevena V.
AU  - Glišić, Sanja
AU  - Colombatti, Alfonso
PY  - 2011
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/4495
AB  - Objectives: The incidence of non-AIDS-defining cancer is remarkably higher in HIV-infected than in the general population. In contrast, breast cancer risk is significantly reduced in the HIV-infected population. The molecular mechanisms underlying the phenomenon of suppression of breast cancer in the HIV-infected population may serve as a basis for development of a new platform for prevention and treatment of breast cancer. Hypothesis: Various evidences indicate that vasoactive intestinal peptide (VIP) plays an important role in growth, and differentiation of breast cancer. We previously showed (i) that natural antibodies recognizing VIP and the gp120-derived peptide NTM significantly contribute to the control of HIV disease progression by suppression of VIP-like activity of HIV-1 gp120 and (ii) that physical exercise stimulates production of these natural antibodies. These findings suggest that natural anti-VIP/NTM antibodies could contribute to a decrease of breast cancer in the HIV-infected population by suppression of VIP, which may play a pro/oncogenic function. Aerobic exercise which stimulates production of anti-VIP/NTM antibodies could be used as prevention and supportive treatment of breast cancer. Impact: Immunotherapy based on natural anti-VIP/NTM antibodies could serve as an effective adjunct therapy for the treatment of breast cancer. Similarly, aerobic exercise, which stimulates production of these antibodies, should be considered as an inexpensive and safe preventive and supportive breast cancer therapy. Natural anti-VIP/NTM antibodies also represent promising prognostic marker for breast cancer. (C) 2011 Elsevier Ltd. All rights reserved.
T2  - Medical Hypotheses
T1  - Can natural antibodies to VIP or VIP-like HIV-1 glycoprotein facilitate prevention and supportive treatment of breast cancer?
VL  - 77
IS  - 3
SP  - 404
EP  - 408
DO  - 10.1016/j.mehy.2011.05.030
ER  - 

@article{
author = "Veljković, Milena and Branch, Donald R. and Dopsaj, Violeta and Veljković, Veljko and Veljković, Nevena V. and Glišić, Sanja and Colombatti, Alfonso",
year = "2011",
abstract = "Objectives: The incidence of non-AIDS-defining cancer is remarkably higher in HIV-infected than in the general population. In contrast, breast cancer risk is significantly reduced in the HIV-infected population. The molecular mechanisms underlying the phenomenon of suppression of breast cancer in the HIV-infected population may serve as a basis for development of a new platform for prevention and treatment of breast cancer. Hypothesis: Various evidences indicate that vasoactive intestinal peptide (VIP) plays an important role in growth, and differentiation of breast cancer. We previously showed (i) that natural antibodies recognizing VIP and the gp120-derived peptide NTM significantly contribute to the control of HIV disease progression by suppression of VIP-like activity of HIV-1 gp120 and (ii) that physical exercise stimulates production of these natural antibodies. These findings suggest that natural anti-VIP/NTM antibodies could contribute to a decrease of breast cancer in the HIV-infected population by suppression of VIP, which may play a pro/oncogenic function. Aerobic exercise which stimulates production of anti-VIP/NTM antibodies could be used as prevention and supportive treatment of breast cancer. Impact: Immunotherapy based on natural anti-VIP/NTM antibodies could serve as an effective adjunct therapy for the treatment of breast cancer. Similarly, aerobic exercise, which stimulates production of these antibodies, should be considered as an inexpensive and safe preventive and supportive breast cancer therapy. Natural anti-VIP/NTM antibodies also represent promising prognostic marker for breast cancer. (C) 2011 Elsevier Ltd. All rights reserved.",
journal = "Medical Hypotheses",
title = "Can natural antibodies to VIP or VIP-like HIV-1 glycoprotein facilitate prevention and supportive treatment of breast cancer?",
volume = "77",
number = "3",
pages = "404-408",
doi = "10.1016/j.mehy.2011.05.030"
}

Veljković, M., Branch, D. R., Dopsaj, V., Veljković, V., Veljković, N. V., Glišić, S.,& Colombatti, A.. (2011). Can natural antibodies to VIP or VIP-like HIV-1 glycoprotein facilitate prevention and supportive treatment of breast cancer?. in Medical Hypotheses, 77(3), 404-408.
https://doi.org/10.1016/j.mehy.2011.05.030

Veljković M, Branch DR, Dopsaj V, Veljković V, Veljković NV, Glišić S, Colombatti A. Can natural antibodies to VIP or VIP-like HIV-1 glycoprotein facilitate prevention and supportive treatment of breast cancer?. in Medical Hypotheses. 2011;77(3):404-408.
doi:10.1016/j.mehy.2011.05.030 .

Veljković, Milena, Branch, Donald R., Dopsaj, Violeta, Veljković, Veljko, Veljković, Nevena V., Glišić, Sanja, Colombatti, Alfonso, "Can natural antibodies to VIP or VIP-like HIV-1 glycoprotein facilitate prevention and supportive treatment of breast cancer?" in Medical Hypotheses, 77, no. 3 (2011):404-408,
https://doi.org/10.1016/j.mehy.2011.05.030 . .