TY  - JOUR
AU  - Čukić, Milena B
AU  - Savić, Danka
AU  - Bachmann, Maie
PY  - 2023
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/11223
T2  - Frontiers in Digital Health
T1  - Editorial: Innovations in depression diagnosis and treatment outcome monitoring
VL  - 5
SP  - 1224999
DO  - 10.3389/fdgth.2023.1224999
ER  - 

@article{
author = "Čukić, Milena B and Savić, Danka and Bachmann, Maie",
year = "2023",
journal = "Frontiers in Digital Health",
title = "Editorial: Innovations in depression diagnosis and treatment outcome monitoring",
volume = "5",
pages = "1224999",
doi = "10.3389/fdgth.2023.1224999"
}

Čukić, M. B., Savić, D.,& Bachmann, M.. (2023). Editorial: Innovations in depression diagnosis and treatment outcome monitoring. in Frontiers in Digital Health, 5, 1224999.
https://doi.org/10.3389/fdgth.2023.1224999

Čukić MB, Savić D, Bachmann M. Editorial: Innovations in depression diagnosis and treatment outcome monitoring. in Frontiers in Digital Health. 2023;5:1224999.
doi:10.3389/fdgth.2023.1224999 .

Čukić, Milena B, Savić, Danka, Bachmann, Maie, "Editorial: Innovations in depression diagnosis and treatment outcome monitoring" in Frontiers in Digital Health, 5 (2023):1224999,
https://doi.org/10.3389/fdgth.2023.1224999 . .

TY  - JOUR
AU  - Čukić, Milena
AU  - Savić, Danka A.
AU  - Sidorova, Julia
PY  - 2023
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10758
AB  - Background: Disturbed heart dynamics in depression seriously increases mortality risk. Heart rate variability (HRV) is a rich source of information for studying this dynamics. This paper is a meta-analytic review with methodological commentary of the application of nonlinear analysis of HRV and its possibility to address cardiovascular diseases in depression. Objective: This paper aimed to appeal for the introduction of cardiological screening to patients with depression, because it is still far from established practice. The other (main) objective of the paper was to show that nonlinear methods in HRV analysis give better results than standard ones. Methods: We systematically searched on the web for papers on nonlinear analyses of HRV in depression, in line with PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) 2020 framework recommendations. We scrutinized the chosen publications and performed random-effects meta-analysis, using the esci module in jamovi software where standardized effect sizes (ESs) are corrected to yield the proof of the practical utility of their results. Results: In all, 26 publications on the connection of nonlinear HRV measures and depression meeting our inclusion criteria were selected, examining a total of 1537 patients diagnosed with depression and 1041 healthy controls (N=2578). The overall ES (unbiased) was 1.03 (95% CI 0.703-1.35; diamond ratio 3.60). We performed 3 more meta-analytic comparisons, demonstrating the overall effectiveness of 3 groups of nonlinear analysis: detrended fluctuation analysis (overall ES 0.364, 95% CI 0.237-0.491), entropy-based measures (overall ES 1.05, 95% CI 0.572-1.52), and all other nonlinear measures (overall ES 0.702, 95% CI 0.422-0.982). The effectiveness of the applied methods of electrocardiogram analysis was compared and discussed in the light of detection and prevention of depression-related cardiovascular risk. Conclusions: We compared the ESs of nonlinear and conventional time and spectral methods (found in the literature) and demonstrated that those of the former are larger, which recommends their use for the early screening of cardiovascular abnormalities in patients with depression to prevent possible deleterious events. ©Milena Čukić, Danka Savić, Julia Sidorova.
T2  - JMIR Mental Health
T1  - When Heart Beats Differently in Depression: Review of Nonlinear Heart Rate Variability Measures
VL  - 10
SP  - e40342
DO  - 10.2196/40342
ER  - 

@article{
author = "Čukić, Milena and Savić, Danka A. and Sidorova, Julia",
year = "2023",
abstract = "Background: Disturbed heart dynamics in depression seriously increases mortality risk. Heart rate variability (HRV) is a rich source of information for studying this dynamics. This paper is a meta-analytic review with methodological commentary of the application of nonlinear analysis of HRV and its possibility to address cardiovascular diseases in depression. Objective: This paper aimed to appeal for the introduction of cardiological screening to patients with depression, because it is still far from established practice. The other (main) objective of the paper was to show that nonlinear methods in HRV analysis give better results than standard ones. Methods: We systematically searched on the web for papers on nonlinear analyses of HRV in depression, in line with PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) 2020 framework recommendations. We scrutinized the chosen publications and performed random-effects meta-analysis, using the esci module in jamovi software where standardized effect sizes (ESs) are corrected to yield the proof of the practical utility of their results. Results: In all, 26 publications on the connection of nonlinear HRV measures and depression meeting our inclusion criteria were selected, examining a total of 1537 patients diagnosed with depression and 1041 healthy controls (N=2578). The overall ES (unbiased) was 1.03 (95% CI 0.703-1.35; diamond ratio 3.60). We performed 3 more meta-analytic comparisons, demonstrating the overall effectiveness of 3 groups of nonlinear analysis: detrended fluctuation analysis (overall ES 0.364, 95% CI 0.237-0.491), entropy-based measures (overall ES 1.05, 95% CI 0.572-1.52), and all other nonlinear measures (overall ES 0.702, 95% CI 0.422-0.982). The effectiveness of the applied methods of electrocardiogram analysis was compared and discussed in the light of detection and prevention of depression-related cardiovascular risk. Conclusions: We compared the ESs of nonlinear and conventional time and spectral methods (found in the literature) and demonstrated that those of the former are larger, which recommends their use for the early screening of cardiovascular abnormalities in patients with depression to prevent possible deleterious events. ©Milena Čukić, Danka Savić, Julia Sidorova.",
journal = "JMIR Mental Health",
title = "When Heart Beats Differently in Depression: Review of Nonlinear Heart Rate Variability Measures",
volume = "10",
pages = "e40342",
doi = "10.2196/40342"
}

Čukić, M., Savić, D. A.,& Sidorova, J.. (2023). When Heart Beats Differently in Depression: Review of Nonlinear Heart Rate Variability Measures. in JMIR Mental Health, 10, e40342.
https://doi.org/10.2196/40342

Čukić M, Savić DA, Sidorova J. When Heart Beats Differently in Depression: Review of Nonlinear Heart Rate Variability Measures. in JMIR Mental Health. 2023;10:e40342.
doi:10.2196/40342 .

Čukić, Milena, Savić, Danka A., Sidorova, Julia, "When Heart Beats Differently in Depression: Review of Nonlinear Heart Rate Variability Measures" in JMIR Mental Health, 10 (2023):e40342,
https://doi.org/10.2196/40342 . .

TY  - JOUR
AU  - Knežević, Goran
AU  - Savić, Danka A.
AU  - Vermetten, Eric
AU  - Vidaković, Ivana
PY  - 2022
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10060
AB  - The aim of the study is to test a model specifying the relations between personality traits, war-related traumas, PTSD and depression, as well as the measurement aspects of the model. This study was carried out in hospital on 400 male participants. Five-Factor Model of personality was complemented by a recently proposed trait Disintegration representing proneness to psychotic-like experiences/behaviors in the general population. The proposed model had excellent fit, despite its complexity. The results show that PTSD or depression symptoms after traumas are largely related to the number of traumas, Neuroticism, Extraversion, and Disintegration, and their different configurations and quantities. Disintegration turned out to be one of the most important dispositional correlates of depression and PTSD, but also of trauma exposure. © 2021
T2  - Journal of Research in Personality
T1  - From war-related trauma exposure to PTSD and depression: A personality perspective
VL  - 96
SP  - 104169
DO  - 10.1016/j.jrp.2021.104169
ER  - 

@article{
author = "Knežević, Goran and Savić, Danka A. and Vermetten, Eric and Vidaković, Ivana",
year = "2022",
abstract = "The aim of the study is to test a model specifying the relations between personality traits, war-related traumas, PTSD and depression, as well as the measurement aspects of the model. This study was carried out in hospital on 400 male participants. Five-Factor Model of personality was complemented by a recently proposed trait Disintegration representing proneness to psychotic-like experiences/behaviors in the general population. The proposed model had excellent fit, despite its complexity. The results show that PTSD or depression symptoms after traumas are largely related to the number of traumas, Neuroticism, Extraversion, and Disintegration, and their different configurations and quantities. Disintegration turned out to be one of the most important dispositional correlates of depression and PTSD, but also of trauma exposure. © 2021",
journal = "Journal of Research in Personality",
title = "From war-related trauma exposure to PTSD and depression: A personality perspective",
volume = "96",
pages = "104169",
doi = "10.1016/j.jrp.2021.104169"
}

Knežević, G., Savić, D. A., Vermetten, E.,& Vidaković, I.. (2022). From war-related trauma exposure to PTSD and depression: A personality perspective. in Journal of Research in Personality, 96, 104169.
https://doi.org/10.1016/j.jrp.2021.104169

Knežević G, Savić DA, Vermetten E, Vidaković I. From war-related trauma exposure to PTSD and depression: A personality perspective. in Journal of Research in Personality. 2022;96:104169.
doi:10.1016/j.jrp.2021.104169 .

Knežević, Goran, Savić, Danka A., Vermetten, Eric, Vidaković, Ivana, "From war-related trauma exposure to PTSD and depression: A personality perspective" in Journal of Research in Personality, 96 (2022):104169,
https://doi.org/10.1016/j.jrp.2021.104169 . .

TY  - JOUR
AU  - Savić, Danka A.
AU  - Knežević, Goran
AU  - Matić, Gordana
AU  - Damjanović, Svetozar S.
PY  - 2018
UR  - http://linkinghub.elsevier.com/retrieve/pii/S030645301830088X
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/7745
AB  - Background Research results on dehydroepiandrosterone sulfate ester (DHEAS) in post-traumatic stress disorder (PTSD) are inconsistent. We hypothesized that personality traits could be the confounders of DHEAS levels and disease symptoms, which could in part explain the discrepancy in findings. Method: This study was a part of a broader project in which simultaneous psychological and biological in-vestigations were carried out in hospital conditions. 380 male subjects were categorized in four groups: A) current PTSD (n = 132), B) lifetime PTSD (n = 66), C) trauma controls (n = 101), and D) healthy controls (n = 81), matched by age. Results: The level of DHEAS is significantly lower in the current PTSD group than in trauma controls. All groups significantly differ in personality traits Disintegration and Neuroticism (current PTSD group having the highest scores). DHEAS is related to both PTSD and depressive symptoms; however, Structural Equation Model (SEM) shows that the relations are indirect, realized via their confounder-personality trait Disintegration. Conclusions: According to our project results, DHEAS is the second putative biomarker for trauma-related dis-orders that fails to fulfil this expectation. It appears to be more directly related to personality than to the disease symptoms (the first one being basal cortisol). Our data promote personality as a biologically based construct with seemingly important role in understanding the mental health status.
T2  - Psychoneuroendocrinology
T1  - PTSD and depressive symptoms are linked to DHEAS via personality
VL  - 92
SP  - 29
EP  - 33
DO  - 10.1016/j.psyneuen.2018.03.017
ER  - 

@article{
author = "Savić, Danka A. and Knežević, Goran and Matić, Gordana and Damjanović, Svetozar S.",
year = "2018",
abstract = "Background Research results on dehydroepiandrosterone sulfate ester (DHEAS) in post-traumatic stress disorder (PTSD) are inconsistent. We hypothesized that personality traits could be the confounders of DHEAS levels and disease symptoms, which could in part explain the discrepancy in findings. Method: This study was a part of a broader project in which simultaneous psychological and biological in-vestigations were carried out in hospital conditions. 380 male subjects were categorized in four groups: A) current PTSD (n = 132), B) lifetime PTSD (n = 66), C) trauma controls (n = 101), and D) healthy controls (n = 81), matched by age. Results: The level of DHEAS is significantly lower in the current PTSD group than in trauma controls. All groups significantly differ in personality traits Disintegration and Neuroticism (current PTSD group having the highest scores). DHEAS is related to both PTSD and depressive symptoms; however, Structural Equation Model (SEM) shows that the relations are indirect, realized via their confounder-personality trait Disintegration. Conclusions: According to our project results, DHEAS is the second putative biomarker for trauma-related dis-orders that fails to fulfil this expectation. It appears to be more directly related to personality than to the disease symptoms (the first one being basal cortisol). Our data promote personality as a biologically based construct with seemingly important role in understanding the mental health status.",
journal = "Psychoneuroendocrinology",
title = "PTSD and depressive symptoms are linked to DHEAS via personality",
volume = "92",
pages = "29-33",
doi = "10.1016/j.psyneuen.2018.03.017"
}

Savić, D. A., Knežević, G., Matić, G.,& Damjanović, S. S.. (2018). PTSD and depressive symptoms are linked to DHEAS via personality. in Psychoneuroendocrinology, 92, 29-33.
https://doi.org/10.1016/j.psyneuen.2018.03.017

Savić DA, Knežević G, Matić G, Damjanović SS. PTSD and depressive symptoms are linked to DHEAS via personality. in Psychoneuroendocrinology. 2018;92:29-33.
doi:10.1016/j.psyneuen.2018.03.017 .

Savić, Danka A., Knežević, Goran, Matić, Gordana, Damjanović, Svetozar S., "PTSD and depressive symptoms are linked to DHEAS via personality" in Psychoneuroendocrinology, 92 (2018):29-33,
https://doi.org/10.1016/j.psyneuen.2018.03.017 . .

TY  - JOUR
AU  - Knežević, Goran
AU  - Savić, Danka A.
AU  - Kutlesic, Vesna
AU  - Opačić, Goran
PY  - 2017
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/1785
AB  - A nine-facet hierarchical taxonomy of Disintegration, a trait-like disposition that causes variations in psychotic-like behavior, is proposed, along with the scales to assess it. Strong correlations were demonstrated in students (n = 466) between lower-level dimensions, independent of the assessment method. Disintegration lay beyond the Five-Factor Model (FFM) space. This finding was replicated across informant types (self, mother, and father), samples (students and a national representative sample, n = 1001), and units of analyses (facets and items). The most frequent approach to preserve the FFM taxonomy of both normal and non-normal personality variants - mapping psychotic-like phenomena onto the Openness domain - found little support in our data. Disintegration was normally distributed in the general population. (C) 2017 Elsevier Inc. All rights reserved.
T2  - Journal of Research in Personality
T1  - Disintegration: A reconceptualization of psychosis proneness as a personality trait separate from the Big Five
VL  - 70
SP  - 187
EP  - 201
DO  - 10.1016/j.jrp.2017.06.001
ER  - 

@article{
author = "Knežević, Goran and Savić, Danka A. and Kutlesic, Vesna and Opačić, Goran",
year = "2017",
abstract = "A nine-facet hierarchical taxonomy of Disintegration, a trait-like disposition that causes variations in psychotic-like behavior, is proposed, along with the scales to assess it. Strong correlations were demonstrated in students (n = 466) between lower-level dimensions, independent of the assessment method. Disintegration lay beyond the Five-Factor Model (FFM) space. This finding was replicated across informant types (self, mother, and father), samples (students and a national representative sample, n = 1001), and units of analyses (facets and items). The most frequent approach to preserve the FFM taxonomy of both normal and non-normal personality variants - mapping psychotic-like phenomena onto the Openness domain - found little support in our data. Disintegration was normally distributed in the general population. (C) 2017 Elsevier Inc. All rights reserved.",
journal = "Journal of Research in Personality",
title = "Disintegration: A reconceptualization of psychosis proneness as a personality trait separate from the Big Five",
volume = "70",
pages = "187-201",
doi = "10.1016/j.jrp.2017.06.001"
}

Knežević, G., Savić, D. A., Kutlesic, V.,& Opačić, G.. (2017). Disintegration: A reconceptualization of psychosis proneness as a personality trait separate from the Big Five. in Journal of Research in Personality, 70, 187-201.
https://doi.org/10.1016/j.jrp.2017.06.001

Knežević G, Savić DA, Kutlesic V, Opačić G. Disintegration: A reconceptualization of psychosis proneness as a personality trait separate from the Big Five. in Journal of Research in Personality. 2017;70:187-201.
doi:10.1016/j.jrp.2017.06.001 .

Knežević, Goran, Savić, Danka A., Kutlesic, Vesna, Opačić, Goran, "Disintegration: A reconceptualization of psychosis proneness as a personality trait separate from the Big Five" in Journal of Research in Personality, 70 (2017):187-201,
https://doi.org/10.1016/j.jrp.2017.06.001 . .

TY  - JOUR
AU  - Savić, Danka A.
AU  - Knežević, Goran
AU  - Matić, Gordana
AU  - Damjanović, Svetozar S.
AU  - Spiric, Zeljko
PY  - 2015
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/554
AB  - A disturbed beta-endorphin system can be a part of the post-traumatic stress disorder (PTSD) and depression allostasis. Study subjects (N=392) included those with PTSD and/or (stress-induced) depression, and healthy controls with and without traumas. The aim of the study was to examine the network of relations centered around plasma beta-endorphin. The network included anxiety (as a personality trait), traumatic events, pain, aggressiveness, depressive symptoms, and three clusters of PTSD symptoms: intrusions, avoidance, and hyperarousal. Beta-endorphin was represented by individual mean from 13 time points (BEmean), reflecting the total amount of the peripherally secreted hormone, and the coefficient of variation (BEvar), calculated as the ratio of standard deviation to the mean, reflecting the hormones dynamics. BEvar correlated with all other variables, BEmean had no correlations. Structural equation modeling (SEM) was used to examine all interrelations (including their directions) of BEvar and the state/trait variables in the context of their entirety. The model revealed that hyperarousal and anxiety were the only direct agents of peripheral beta-endorphin fluctuations, mediating the effects of other variables. Traumatic events and intrusions act on BEvar via hyperarousal, while depressive symptoms, avoidance, and pain act via anxiety. Hyperarousal should be emphasized as the main agent not only because its effect on BEvar is larger than that of anxiety, but also because it increases anxiety itself (via avoidance and pain). All influences on BEvar are positive and they indicate long-term (sensitizing) effects (as opposed to direct stimulation, for example, by acute pain, anger, etc.). Relations apart from beta-endorphin are also discussed. (C) 2015 Elsevier B.V. All rights reserved,
T2  - Journal of Affective Disorders
T1  - Posttraumatic and depressive symptoms in beta-endorphin dynamics
VL  - 181
SP  - 61
EP  - 66
DO  - 10.1016/j.jad.2015.03.063
ER  - 

@article{
author = "Savić, Danka A. and Knežević, Goran and Matić, Gordana and Damjanović, Svetozar S. and Spiric, Zeljko",
year = "2015",
abstract = "A disturbed beta-endorphin system can be a part of the post-traumatic stress disorder (PTSD) and depression allostasis. Study subjects (N=392) included those with PTSD and/or (stress-induced) depression, and healthy controls with and without traumas. The aim of the study was to examine the network of relations centered around plasma beta-endorphin. The network included anxiety (as a personality trait), traumatic events, pain, aggressiveness, depressive symptoms, and three clusters of PTSD symptoms: intrusions, avoidance, and hyperarousal. Beta-endorphin was represented by individual mean from 13 time points (BEmean), reflecting the total amount of the peripherally secreted hormone, and the coefficient of variation (BEvar), calculated as the ratio of standard deviation to the mean, reflecting the hormones dynamics. BEvar correlated with all other variables, BEmean had no correlations. Structural equation modeling (SEM) was used to examine all interrelations (including their directions) of BEvar and the state/trait variables in the context of their entirety. The model revealed that hyperarousal and anxiety were the only direct agents of peripheral beta-endorphin fluctuations, mediating the effects of other variables. Traumatic events and intrusions act on BEvar via hyperarousal, while depressive symptoms, avoidance, and pain act via anxiety. Hyperarousal should be emphasized as the main agent not only because its effect on BEvar is larger than that of anxiety, but also because it increases anxiety itself (via avoidance and pain). All influences on BEvar are positive and they indicate long-term (sensitizing) effects (as opposed to direct stimulation, for example, by acute pain, anger, etc.). Relations apart from beta-endorphin are also discussed. (C) 2015 Elsevier B.V. All rights reserved,",
journal = "Journal of Affective Disorders",
title = "Posttraumatic and depressive symptoms in beta-endorphin dynamics",
volume = "181",
pages = "61-66",
doi = "10.1016/j.jad.2015.03.063"
}

Savić, D. A., Knežević, G., Matić, G., Damjanović, S. S.,& Spiric, Z.. (2015). Posttraumatic and depressive symptoms in beta-endorphin dynamics. in Journal of Affective Disorders, 181, 61-66.
https://doi.org/10.1016/j.jad.2015.03.063

Savić DA, Knežević G, Matić G, Damjanović SS, Spiric Z. Posttraumatic and depressive symptoms in beta-endorphin dynamics. in Journal of Affective Disorders. 2015;181:61-66.
doi:10.1016/j.jad.2015.03.063 .

Savić, Danka A., Knežević, Goran, Matić, Gordana, Damjanović, Svetozar S., Spiric, Zeljko, "Posttraumatic and depressive symptoms in beta-endorphin dynamics" in Journal of Affective Disorders, 181 (2015):61-66,
https://doi.org/10.1016/j.jad.2015.03.063 . .

TY  - JOUR
AU  - Matić, Gordana
AU  - Milutinovic, Danijela Vojnovic
AU  - Nestorov, Jelena
AU  - Elaković, Ivana
AU  - Jovanovic, Sanja Manitasevic
AU  - Elzaedi, Younis Mouftah
AU  - Perisic, Tatjana
AU  - Dunderski, Jadranka
AU  - Damjanović, Svetozar S.
AU  - Knežević, Goran
AU  - Spiric, Zeljko
AU  - Vermetten, Eric
AU  - Savić, Danka A.
PY  - 2014
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/5909
AB  - Alterations in the number and functional status of mineralocorticoid (MR) and glucocorticoid receptors (GR) may contribute to vulnerability to posttraumatic stress disorder (PTSD). Corticosteroid receptors are chaperoned by heat shock proteins Hsp90 and Hsp70. We examined relations between corticosteroid receptor and heat shock protein expression levels, and related them with war trauma exposure, PTSD and resilience to PTSD. Relative levels of MR. Hsp90 and Hsp70 were determined by immunoblotting in lymphocytes from war trauma-exposed men with current PTSD (current PTSD group, n=113), with lifetime PTSD (life-time PTSD group, n=61) and without PTSD (trauma control group, n=88), and from non-traumatized healthy controls (healthy control group, n=85). Between-group differences in MR, Hsp90 and Hsp70 levels and in MR/GR ratio were not observed. The level of MR was correlated with both Hsp90 and Hsp70 levels in trauma control and healthy control groups. On the other hand, GR level was correlated only with Hsp90 level, and this correlation was evident in current PTSD and trauma control groups. In conclusion, PTSD and exposure to trauma are not related to changes in lymphocyte MR, Hsp90 or Hsp70 levels, but may be associated with disturbances in corticosteroid receptors interaction with heat shock proteins. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
T2  - Psychiatry Research
T1  - Mineralocorticoid receptor and heat shock protein expression levels in peripheral lymphocytes from war trauma-exposed men with and without PTSD
VL  - 215
IS  - 2
SP  - 379
EP  - 385
DO  - 10.1016/j.psychres.2013.11.022
ER  - 

@article{
author = "Matić, Gordana and Milutinovic, Danijela Vojnovic and Nestorov, Jelena and Elaković, Ivana and Jovanovic, Sanja Manitasevic and Elzaedi, Younis Mouftah and Perisic, Tatjana and Dunderski, Jadranka and Damjanović, Svetozar S. and Knežević, Goran and Spiric, Zeljko and Vermetten, Eric and Savić, Danka A.",
year = "2014",
abstract = "Alterations in the number and functional status of mineralocorticoid (MR) and glucocorticoid receptors (GR) may contribute to vulnerability to posttraumatic stress disorder (PTSD). Corticosteroid receptors are chaperoned by heat shock proteins Hsp90 and Hsp70. We examined relations between corticosteroid receptor and heat shock protein expression levels, and related them with war trauma exposure, PTSD and resilience to PTSD. Relative levels of MR. Hsp90 and Hsp70 were determined by immunoblotting in lymphocytes from war trauma-exposed men with current PTSD (current PTSD group, n=113), with lifetime PTSD (life-time PTSD group, n=61) and without PTSD (trauma control group, n=88), and from non-traumatized healthy controls (healthy control group, n=85). Between-group differences in MR, Hsp90 and Hsp70 levels and in MR/GR ratio were not observed. The level of MR was correlated with both Hsp90 and Hsp70 levels in trauma control and healthy control groups. On the other hand, GR level was correlated only with Hsp90 level, and this correlation was evident in current PTSD and trauma control groups. In conclusion, PTSD and exposure to trauma are not related to changes in lymphocyte MR, Hsp90 or Hsp70 levels, but may be associated with disturbances in corticosteroid receptors interaction with heat shock proteins. (C) 2013 Elsevier Ireland Ltd. All rights reserved.",
journal = "Psychiatry Research",
title = "Mineralocorticoid receptor and heat shock protein expression levels in peripheral lymphocytes from war trauma-exposed men with and without PTSD",
volume = "215",
number = "2",
pages = "379-385",
doi = "10.1016/j.psychres.2013.11.022"
}

Matić, G., Milutinovic, D. V., Nestorov, J., Elaković, I., Jovanovic, S. M., Elzaedi, Y. M., Perisic, T., Dunderski, J., Damjanović, S. S., Knežević, G., Spiric, Z., Vermetten, E.,& Savić, D. A.. (2014). Mineralocorticoid receptor and heat shock protein expression levels in peripheral lymphocytes from war trauma-exposed men with and without PTSD. in Psychiatry Research, 215(2), 379-385.
https://doi.org/10.1016/j.psychres.2013.11.022

Matić G, Milutinovic DV, Nestorov J, Elaković I, Jovanovic SM, Elzaedi YM, Perisic T, Dunderski J, Damjanović SS, Knežević G, Spiric Z, Vermetten E, Savić DA. Mineralocorticoid receptor and heat shock protein expression levels in peripheral lymphocytes from war trauma-exposed men with and without PTSD. in Psychiatry Research. 2014;215(2):379-385.
doi:10.1016/j.psychres.2013.11.022 .

Matić, Gordana, Milutinovic, Danijela Vojnovic, Nestorov, Jelena, Elaković, Ivana, Jovanovic, Sanja Manitasevic, Elzaedi, Younis Mouftah, Perisic, Tatjana, Dunderski, Jadranka, Damjanović, Svetozar S., Knežević, Goran, Spiric, Zeljko, Vermetten, Eric, Savić, Danka A., "Mineralocorticoid receptor and heat shock protein expression levels in peripheral lymphocytes from war trauma-exposed men with and without PTSD" in Psychiatry Research, 215, no. 2 (2014):379-385,
https://doi.org/10.1016/j.psychres.2013.11.022 . .

TY  - JOUR
AU  - Savić, Danka A.
AU  - Knežević, Goran
AU  - Damjanović, Svetozar S.
AU  - Antic, Jadranka
AU  - Matić, Gordana
PY  - 2014
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/108
AB  - Background: The hypothalamo-pituitary-adrenocortical (HPA) axis self-regulation is achieved via cortisol binding to mineralocorticoid (MR) and glucocorticoid receptors (GR). It is often disturbed in mental disorders, particularly in those where traumatic stress has been implicated, such as posttraumatic stress disorder and depression. Although dexamethasone suppression test (DST) is often used as diagnostic aid, the findings still vary. In search of the factors influencing the DST outcome, we examined the glucocorticoicl receptor (GR) gene Bell polymorphism. Methods: A total of 229 male subjects were classified into three Bell groups: two groups with homozygous carriers (of the G allele, N=108, and of the C allele, N=26), and one with heterozygous carriers (N=95). Multiple hierarchical linear regression analysis was clone, where the dependent variable was the clexamethasone-inclucecl cortisol suppression, and predictors included receptor variables. The interactions of the count of Gs with the predictors were introduced to single out the effects of the G allele. Results: The means of all studied variables, including suppression, are statistically the same in the three groups. However, the mechanism of suppression involves MRs only in the G allele carriers. Limitations: The subjects were selected by criteria suited for the aim of the large project whose part is this study, hence the relatively small number of CC carriers. Also, we did not assess MR functional properties that would probably sharpen the results. Conclusion: Our finding that MRs participate in cortisol suppression in the G allele carriers suggests that research aimed at refining HPA axis-based therapy might require its adjustment for such patients., (C) 2014 Elsevier By. All rights reserved.
T2  - Journal of Affective Disorders
T1  - GR gene BclI polymorphysm changes the path, but not the level, of dexamethasone-induced cortisol suppression
VL  - 168
SP  - 1
EP  - 4
DO  - 10.1016/j.jad.2014.06.046
ER  - 

@article{
author = "Savić, Danka A. and Knežević, Goran and Damjanović, Svetozar S. and Antic, Jadranka and Matić, Gordana",
year = "2014",
abstract = "Background: The hypothalamo-pituitary-adrenocortical (HPA) axis self-regulation is achieved via cortisol binding to mineralocorticoid (MR) and glucocorticoid receptors (GR). It is often disturbed in mental disorders, particularly in those where traumatic stress has been implicated, such as posttraumatic stress disorder and depression. Although dexamethasone suppression test (DST) is often used as diagnostic aid, the findings still vary. In search of the factors influencing the DST outcome, we examined the glucocorticoicl receptor (GR) gene Bell polymorphism. Methods: A total of 229 male subjects were classified into three Bell groups: two groups with homozygous carriers (of the G allele, N=108, and of the C allele, N=26), and one with heterozygous carriers (N=95). Multiple hierarchical linear regression analysis was clone, where the dependent variable was the clexamethasone-inclucecl cortisol suppression, and predictors included receptor variables. The interactions of the count of Gs with the predictors were introduced to single out the effects of the G allele. Results: The means of all studied variables, including suppression, are statistically the same in the three groups. However, the mechanism of suppression involves MRs only in the G allele carriers. Limitations: The subjects were selected by criteria suited for the aim of the large project whose part is this study, hence the relatively small number of CC carriers. Also, we did not assess MR functional properties that would probably sharpen the results. Conclusion: Our finding that MRs participate in cortisol suppression in the G allele carriers suggests that research aimed at refining HPA axis-based therapy might require its adjustment for such patients., (C) 2014 Elsevier By. All rights reserved.",
journal = "Journal of Affective Disorders",
title = "GR gene BclI polymorphysm changes the path, but not the level, of dexamethasone-induced cortisol suppression",
volume = "168",
pages = "1-4",
doi = "10.1016/j.jad.2014.06.046"
}

Savić, D. A., Knežević, G., Damjanović, S. S., Antic, J.,& Matić, G.. (2014). GR gene BclI polymorphysm changes the path, but not the level, of dexamethasone-induced cortisol suppression. in Journal of Affective Disorders, 168, 1-4.
https://doi.org/10.1016/j.jad.2014.06.046

Savić DA, Knežević G, Damjanović SS, Antic J, Matić G. GR gene BclI polymorphysm changes the path, but not the level, of dexamethasone-induced cortisol suppression. in Journal of Affective Disorders. 2014;168:1-4.
doi:10.1016/j.jad.2014.06.046 .

Savić, Danka A., Knežević, Goran, Damjanović, Svetozar S., Antic, Jadranka, Matić, Gordana, "GR gene BclI polymorphysm changes the path, but not the level, of dexamethasone-induced cortisol suppression" in Journal of Affective Disorders, 168 (2014):1-4,
https://doi.org/10.1016/j.jad.2014.06.046 . .

TY  - JOUR
AU  - Simić, Iva
AU  - Adžić, Miroslav
AU  - Marić, Nađa
AU  - Savić, Danka A.
AU  - Đorđević, Jelena D.
AU  - Mihaljević, Marina
AU  - Mitić, Miloš
AU  - Pavlović, Zorana
AU  - Soldatovic, Ivan
AU  - Krstić-Demonacos, Marija
AU  - Jasovic-Gasic, Miroslava
AU  - Radoičić, Marija B.
PY  - 2013
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/5753
AB  - The mechanism of maladaptive chronic stress response involves altered phosphorylation of the glucocorticoid receptor (GR). In this study, we investigated if important depressogenic vulnerability factors, such as neuroticism and self-reports of negative affective states, may be associated with alterations in levels of the GR and GR phosphoisoforms in peripheral blood mononuclear cells (PBMC) of healthy adults. In 21 women and 16 men we evaluated PMBC levels of total GR (tGR), GR phosphorylated at serine 211 (pGR-S211) and serine 226 (pGR-S226) and correlated these data with personality traits and current reports of stress, anxiety and depression. Also, we assessed plasma cortisol levels in all tested subjects. Our results showed that in women nuclear pGR-S226 was positively correlated with neuroticism and current reports of depression, anxiety and stress, while the ratio of nuclear pGR-S211/pGR-S226 was negatively correlated with reports of depression. None of the aforementioned correlations were significant in men. No significant relations between cortisol levels and any of GR parameters were observed. These preliminary findings highlight the value of GR phosphorylation-related research in identifying molecular biomarkers of depressogenic vulnerability, at least in women. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
T2  - Psychiatry Research
T1  - A preliminary evaluation of leukocyte phospho-glucocorticoid receptor as a potential biomarker of depressogenic vulnerability in healthy adults
VL  - 209
IS  - 3
SP  - 658
EP  - 664
DO  - 10.1016/j.psychres.2013.02.002
ER  - 

@article{
author = "Simić, Iva and Adžić, Miroslav and Marić, Nađa and Savić, Danka A. and Đorđević, Jelena D. and Mihaljević, Marina and Mitić, Miloš and Pavlović, Zorana and Soldatovic, Ivan and Krstić-Demonacos, Marija and Jasovic-Gasic, Miroslava and Radoičić, Marija B.",
year = "2013",
abstract = "The mechanism of maladaptive chronic stress response involves altered phosphorylation of the glucocorticoid receptor (GR). In this study, we investigated if important depressogenic vulnerability factors, such as neuroticism and self-reports of negative affective states, may be associated with alterations in levels of the GR and GR phosphoisoforms in peripheral blood mononuclear cells (PBMC) of healthy adults. In 21 women and 16 men we evaluated PMBC levels of total GR (tGR), GR phosphorylated at serine 211 (pGR-S211) and serine 226 (pGR-S226) and correlated these data with personality traits and current reports of stress, anxiety and depression. Also, we assessed plasma cortisol levels in all tested subjects. Our results showed that in women nuclear pGR-S226 was positively correlated with neuroticism and current reports of depression, anxiety and stress, while the ratio of nuclear pGR-S211/pGR-S226 was negatively correlated with reports of depression. None of the aforementioned correlations were significant in men. No significant relations between cortisol levels and any of GR parameters were observed. These preliminary findings highlight the value of GR phosphorylation-related research in identifying molecular biomarkers of depressogenic vulnerability, at least in women. (C) 2013 Elsevier Ireland Ltd. All rights reserved.",
journal = "Psychiatry Research",
title = "A preliminary evaluation of leukocyte phospho-glucocorticoid receptor as a potential biomarker of depressogenic vulnerability in healthy adults",
volume = "209",
number = "3",
pages = "658-664",
doi = "10.1016/j.psychres.2013.02.002"
}

Simić, I., Adžić, M., Marić, N., Savić, D. A., Đorđević, J. D., Mihaljević, M., Mitić, M., Pavlović, Z., Soldatovic, I., Krstić-Demonacos, M., Jasovic-Gasic, M.,& Radoičić, M. B.. (2013). A preliminary evaluation of leukocyte phospho-glucocorticoid receptor as a potential biomarker of depressogenic vulnerability in healthy adults. in Psychiatry Research, 209(3), 658-664.
https://doi.org/10.1016/j.psychres.2013.02.002

Simić I, Adžić M, Marić N, Savić DA, Đorđević JD, Mihaljević M, Mitić M, Pavlović Z, Soldatovic I, Krstić-Demonacos M, Jasovic-Gasic M, Radoičić MB. A preliminary evaluation of leukocyte phospho-glucocorticoid receptor as a potential biomarker of depressogenic vulnerability in healthy adults. in Psychiatry Research. 2013;209(3):658-664.
doi:10.1016/j.psychres.2013.02.002 .

Simić, Iva, Adžić, Miroslav, Marić, Nađa, Savić, Danka A., Đorđević, Jelena D., Mihaljević, Marina, Mitić, Miloš, Pavlović, Zorana, Soldatovic, Ivan, Krstić-Demonacos, Marija, Jasovic-Gasic, Miroslava, Radoičić, Marija B., "A preliminary evaluation of leukocyte phospho-glucocorticoid receptor as a potential biomarker of depressogenic vulnerability in healthy adults" in Psychiatry Research, 209, no. 3 (2013):658-664,
https://doi.org/10.1016/j.psychres.2013.02.002 . .

TY  - JOUR
AU  - Matić, Gordana
AU  - Milutinovic, Danijela Vojnovic
AU  - Nestorov, Jelena
AU  - Elaković, Ivana
AU  - Jovanovic, Sanja Manitasevic
AU  - Perisic, Tatjana
AU  - Dunderski, Jadranka
AU  - Damjanović, Svetozar S.
AU  - Knežević, Goran
AU  - Spiric, Zeljko
AU  - Vermetten, Eric
AU  - Savić, Danka A.
PY  - 2013
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/5429
AB  - Objective: Posttraumatic stress disorder (PTSD) has been shown to be associated with altered glucocorticoid receptor (GR) activity. We studied the expression and functional properties of the receptor in peripheral blood mononuclear cells (PBMCs) from non-traumatized healthy individuals (healthy controls; n = 85), and war trauma-exposed individuals with current PTSD (n = 113), with life-time PTSD (n = 61) and without PTSD (trauma controls; n = 88). The aim of the study was to distinguish the receptor alterations related to PTSD from those related to trauma itself or to resilience to PTSD. Methods: Functional status of the receptor was assessed by radioligand binding and lysozyme synthesis inhibition assays. The level of GR gene expression was measured by quantitative PCR and immunoblotting. Results: Current PTSD patients had the lowest, while trauma controls had the highest number of glucocorticoid binding sites (B-max) in PBMCs. Hormone-binding potential (B-max/K-D ratio) of the receptor was diminished in the current PTSD group in comparison to all other study groups. Correlation between B-max and K-D that normally exists in healthy individuals was decreased in the current PTSD group. Contrasting B-max data, GR protein level was lower in trauma controls than in participants with current or life-time PTSD. Conclusions: Current PTSD is characterized by reduced lymphocyte GR hormone-binding potential and by disturbed compensation between B-max and hormone-binding affinity. Resilience to PTSD is associated with enlarged fraction of the receptor molecules capable of hormone binding, within the total receptor molecule population in PBMCs. (C) 2013 Elsevier Inc. All rights reserved.
T2  - Progress in Neuro-psychopharmacology and Biological Psychiatry
T1  - Lymphocyte glucocorticoid receptor expression level and hormone-binding properties differ between war trauma-exposed men with and without PTSD
VL  - 43
SP  - 238
EP  - 245
DO  - 10.1016/j.pnpbp.2013.01.005
ER  - 

@article{
author = "Matić, Gordana and Milutinovic, Danijela Vojnovic and Nestorov, Jelena and Elaković, Ivana and Jovanovic, Sanja Manitasevic and Perisic, Tatjana and Dunderski, Jadranka and Damjanović, Svetozar S. and Knežević, Goran and Spiric, Zeljko and Vermetten, Eric and Savić, Danka A.",
year = "2013",
abstract = "Objective: Posttraumatic stress disorder (PTSD) has been shown to be associated with altered glucocorticoid receptor (GR) activity. We studied the expression and functional properties of the receptor in peripheral blood mononuclear cells (PBMCs) from non-traumatized healthy individuals (healthy controls; n = 85), and war trauma-exposed individuals with current PTSD (n = 113), with life-time PTSD (n = 61) and without PTSD (trauma controls; n = 88). The aim of the study was to distinguish the receptor alterations related to PTSD from those related to trauma itself or to resilience to PTSD. Methods: Functional status of the receptor was assessed by radioligand binding and lysozyme synthesis inhibition assays. The level of GR gene expression was measured by quantitative PCR and immunoblotting. Results: Current PTSD patients had the lowest, while trauma controls had the highest number of glucocorticoid binding sites (B-max) in PBMCs. Hormone-binding potential (B-max/K-D ratio) of the receptor was diminished in the current PTSD group in comparison to all other study groups. Correlation between B-max and K-D that normally exists in healthy individuals was decreased in the current PTSD group. Contrasting B-max data, GR protein level was lower in trauma controls than in participants with current or life-time PTSD. Conclusions: Current PTSD is characterized by reduced lymphocyte GR hormone-binding potential and by disturbed compensation between B-max and hormone-binding affinity. Resilience to PTSD is associated with enlarged fraction of the receptor molecules capable of hormone binding, within the total receptor molecule population in PBMCs. (C) 2013 Elsevier Inc. All rights reserved.",
journal = "Progress in Neuro-psychopharmacology and Biological Psychiatry",
title = "Lymphocyte glucocorticoid receptor expression level and hormone-binding properties differ between war trauma-exposed men with and without PTSD",
volume = "43",
pages = "238-245",
doi = "10.1016/j.pnpbp.2013.01.005"
}

Matić, G., Milutinovic, D. V., Nestorov, J., Elaković, I., Jovanovic, S. M., Perisic, T., Dunderski, J., Damjanović, S. S., Knežević, G., Spiric, Z., Vermetten, E.,& Savić, D. A.. (2013). Lymphocyte glucocorticoid receptor expression level and hormone-binding properties differ between war trauma-exposed men with and without PTSD. in Progress in Neuro-psychopharmacology and Biological Psychiatry, 43, 238-245.
https://doi.org/10.1016/j.pnpbp.2013.01.005

Matić G, Milutinovic DV, Nestorov J, Elaković I, Jovanovic SM, Perisic T, Dunderski J, Damjanović SS, Knežević G, Spiric Z, Vermetten E, Savić DA. Lymphocyte glucocorticoid receptor expression level and hormone-binding properties differ between war trauma-exposed men with and without PTSD. in Progress in Neuro-psychopharmacology and Biological Psychiatry. 2013;43:238-245.
doi:10.1016/j.pnpbp.2013.01.005 .

Matić, Gordana, Milutinovic, Danijela Vojnovic, Nestorov, Jelena, Elaković, Ivana, Jovanovic, Sanja Manitasevic, Perisic, Tatjana, Dunderski, Jadranka, Damjanović, Svetozar S., Knežević, Goran, Spiric, Zeljko, Vermetten, Eric, Savić, Danka A., "Lymphocyte glucocorticoid receptor expression level and hormone-binding properties differ between war trauma-exposed men with and without PTSD" in Progress in Neuro-psychopharmacology and Biological Psychiatry, 43 (2013):238-245,
https://doi.org/10.1016/j.pnpbp.2013.01.005 . .

TY  - CONF
AU  - Maric, N. P.
AU  - Simić, Iva
AU  - Adžić, Miroslav
AU  - Savić, Danka A.
AU  - Đorđević, Jelena D.
AU  - Mihaljevic, M.
AU  - Mitić, Miloš
AU  - Pavlović, Z.
AU  - Soldatovic, I.
AU  - Krstić-Demonacos, Marija
AU  - Jasovic-Gasic, M.
AU  - Radojčić, Marija
PY  - 2012
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/4969
C3  - European Psychiatry
T1  - Phosphorylation of Leukocyte Glucocorticoid Receptor as a Measure of Stress Vulnerability in Healthy Women and Men
VL  - 27
UR  - https://hdl.handle.net/21.15107/rcub_vinar_4969
ER  - 

@conference{
author = "Maric, N. P. and Simić, Iva and Adžić, Miroslav and Savić, Danka A. and Đorđević, Jelena D. and Mihaljevic, M. and Mitić, Miloš and Pavlović, Z. and Soldatovic, I. and Krstić-Demonacos, Marija and Jasovic-Gasic, M. and Radojčić, Marija",
year = "2012",
journal = "European Psychiatry",
title = "Phosphorylation of Leukocyte Glucocorticoid Receptor as a Measure of Stress Vulnerability in Healthy Women and Men",
volume = "27",
url = "https://hdl.handle.net/21.15107/rcub_vinar_4969"
}

Maric, N. P., Simić, I., Adžić, M., Savić, D. A., Đorđević, J. D., Mihaljevic, M., Mitić, M., Pavlović, Z., Soldatovic, I., Krstić-Demonacos, M., Jasovic-Gasic, M.,& Radojčić, M.. (2012). Phosphorylation of Leukocyte Glucocorticoid Receptor as a Measure of Stress Vulnerability in Healthy Women and Men. in European Psychiatry, 27.
https://hdl.handle.net/21.15107/rcub_vinar_4969

Maric NP, Simić I, Adžić M, Savić DA, Đorđević JD, Mihaljevic M, Mitić M, Pavlović Z, Soldatovic I, Krstić-Demonacos M, Jasovic-Gasic M, Radojčić M. Phosphorylation of Leukocyte Glucocorticoid Receptor as a Measure of Stress Vulnerability in Healthy Women and Men. in European Psychiatry. 2012;27.
https://hdl.handle.net/21.15107/rcub_vinar_4969 .

Maric, N. P., Simić, Iva, Adžić, Miroslav, Savić, Danka A., Đorđević, Jelena D., Mihaljevic, M., Mitić, Miloš, Pavlović, Z., Soldatovic, I., Krstić-Demonacos, Marija, Jasovic-Gasic, M., Radojčić, Marija, "Phosphorylation of Leukocyte Glucocorticoid Receptor as a Measure of Stress Vulnerability in Healthy Women and Men" in European Psychiatry, 27 (2012),
https://hdl.handle.net/21.15107/rcub_vinar_4969 .

TY  - JOUR
AU  - Savić, Danka A.
AU  - Knežević, Goran
AU  - Damjanović, Svetozar S.
AU  - Spiric, Zeljko
AU  - Matić, Gordana
PY  - 2012
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/4879
AB  - Background: Studies of cortisol in post-traumatic stress disorder (PTSD) have yielded mixed results. We hypothesize that personality traits and traumatic experiences could be the confounders of cortisol measures and disease symptoms. Method: This study was a part of a broader project in which simultaneous psychological and biological investigations were carried out in hospital conditions on 400 male participants categorized by four groups: (A) 133 with current PTSD, (B) 66 with lifetime PTSD, (C) 102 trauma controls, and (D) 99 healthy controls (matched by age and education). Cortisol and ACTH were measured in blood samples taken hourly from 22:00 h to 09:00 h, with an additional sample at 07:30 h (resting state and morning rise). The next night, dexamethasone (0.5 mg) suppression test was performed. Results: No significant differences in basal cortisol and ACTH were found between study groups. The trait Conscientiousness, negatively modulated by Extraversion (assessed by NEO Personality Inventory-Revised) was found to correlate with cortisol (but not with ACTH). Group differences are found on suppression. Structural equation modeling shows excellent fit only when the paths (influences) from Conscientiousness to basal cortisol and from traumatic events to suppression are present. The paths connecting suppression and PTSD symptoms do not contribute. Conclusions: Two sources of differences of hypothalamo-pituitary-adrenocortical axis functioning are implied, both only indirectly connected to PTSD. It seems that basal cortisol secretion is associated more tightly with personality (introvertively modulated Conscientiousness), while the regulation by glucocorticoid receptor system is sensitized by repeated traumatic situations. (c) 2011 Elsevier Ltd. All rights reserved.
T2  - Psychoneuroendocrinology
T1  - The role of personality and traumatic events in cortisol levels - Where does PTSD fit in?
VL  - 37
IS  - 7
SP  - 937
EP  - 947
DO  - 10.1016/j.psyneuen.2011.11.001
ER  - 

@article{
author = "Savić, Danka A. and Knežević, Goran and Damjanović, Svetozar S. and Spiric, Zeljko and Matić, Gordana",
year = "2012",
abstract = "Background: Studies of cortisol in post-traumatic stress disorder (PTSD) have yielded mixed results. We hypothesize that personality traits and traumatic experiences could be the confounders of cortisol measures and disease symptoms. Method: This study was a part of a broader project in which simultaneous psychological and biological investigations were carried out in hospital conditions on 400 male participants categorized by four groups: (A) 133 with current PTSD, (B) 66 with lifetime PTSD, (C) 102 trauma controls, and (D) 99 healthy controls (matched by age and education). Cortisol and ACTH were measured in blood samples taken hourly from 22:00 h to 09:00 h, with an additional sample at 07:30 h (resting state and morning rise). The next night, dexamethasone (0.5 mg) suppression test was performed. Results: No significant differences in basal cortisol and ACTH were found between study groups. The trait Conscientiousness, negatively modulated by Extraversion (assessed by NEO Personality Inventory-Revised) was found to correlate with cortisol (but not with ACTH). Group differences are found on suppression. Structural equation modeling shows excellent fit only when the paths (influences) from Conscientiousness to basal cortisol and from traumatic events to suppression are present. The paths connecting suppression and PTSD symptoms do not contribute. Conclusions: Two sources of differences of hypothalamo-pituitary-adrenocortical axis functioning are implied, both only indirectly connected to PTSD. It seems that basal cortisol secretion is associated more tightly with personality (introvertively modulated Conscientiousness), while the regulation by glucocorticoid receptor system is sensitized by repeated traumatic situations. (c) 2011 Elsevier Ltd. All rights reserved.",
journal = "Psychoneuroendocrinology",
title = "The role of personality and traumatic events in cortisol levels - Where does PTSD fit in?",
volume = "37",
number = "7",
pages = "937-947",
doi = "10.1016/j.psyneuen.2011.11.001"
}

Savić, D. A., Knežević, G., Damjanović, S. S., Spiric, Z.,& Matić, G.. (2012). The role of personality and traumatic events in cortisol levels - Where does PTSD fit in?. in Psychoneuroendocrinology, 37(7), 937-947.
https://doi.org/10.1016/j.psyneuen.2011.11.001

Savić DA, Knežević G, Damjanović SS, Spiric Z, Matić G. The role of personality and traumatic events in cortisol levels - Where does PTSD fit in?. in Psychoneuroendocrinology. 2012;37(7):937-947.
doi:10.1016/j.psyneuen.2011.11.001 .

Savić, Danka A., Knežević, Goran, Damjanović, Svetozar S., Spiric, Zeljko, Matić, Gordana, "The role of personality and traumatic events in cortisol levels - Where does PTSD fit in?" in Psychoneuroendocrinology, 37, no. 7 (2012):937-947,
https://doi.org/10.1016/j.psyneuen.2011.11.001 . .

TY  - JOUR
AU  - Savić, Danka A.
AU  - Knežević, Goran
AU  - Damjanović, Svetozar S.
AU  - Spiric, Zeljko
AU  - Matić, Gordana
PY  - 2012
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/4997
AB  - The use of the low-dose dexamethasone suppression test (DST) as a potentially discriminative marker between post-traumatic stress disorder (PTSD) and depression is still under discussion. In order to compare the influence of these psychopathologies on the DST results, we examined suppression in war-traumatized subjects with one or both of these disorders, as well as in healthy controls. Based on our previous findings, we hypothesized that subjects with any disorder would exhibit higher dexamethasone suppression than healthy controls due to traumatic experiences. This study was a part of a broader project in which simultaneous psychological and biological investigations were carried out in hospital conditions on 399 mate participants: 57 with PTSD, 28 with depression, 76 with PTSD + depression, and 238 healthy controls. Cortisol was measured in blood samples taken at 0900 h before and after administering 0.5 mg of dexamethasone (at 2300 h). Group means standard deviation of cortisol suppression were: 79.4 +/- 18.5 in the PTSD group, 80.8 +/- 11.6 in the depression group, 77.5 +/- 24.6 in the group with PTSD+depression, and 66.8 +/- 34.6 in healthy controls. The first three groups suppressed significantly more than the fourth. When the number of traumas was introduced as a covariate, the differences disappeared. The hypothesis was confirmed: in respect to DST, the examined trauma-related psychopathologies showed the same pattern: hypersuppression, due to multiple traumatic experiences. (C) 2012 Elsevier Ltd. All rights reserved.
T2  - Psychoneuroendocrinology
T1  - Is there a biological difference between trauma-related depression and PTSD? DST says NO
VL  - 37
IS  - 9
SP  - 1516
EP  - 1520
DO  - 10.1016/j.psyneuen.2012.02.005
ER  - 

@article{
author = "Savić, Danka A. and Knežević, Goran and Damjanović, Svetozar S. and Spiric, Zeljko and Matić, Gordana",
year = "2012",
abstract = "The use of the low-dose dexamethasone suppression test (DST) as a potentially discriminative marker between post-traumatic stress disorder (PTSD) and depression is still under discussion. In order to compare the influence of these psychopathologies on the DST results, we examined suppression in war-traumatized subjects with one or both of these disorders, as well as in healthy controls. Based on our previous findings, we hypothesized that subjects with any disorder would exhibit higher dexamethasone suppression than healthy controls due to traumatic experiences. This study was a part of a broader project in which simultaneous psychological and biological investigations were carried out in hospital conditions on 399 mate participants: 57 with PTSD, 28 with depression, 76 with PTSD + depression, and 238 healthy controls. Cortisol was measured in blood samples taken at 0900 h before and after administering 0.5 mg of dexamethasone (at 2300 h). Group means standard deviation of cortisol suppression were: 79.4 +/- 18.5 in the PTSD group, 80.8 +/- 11.6 in the depression group, 77.5 +/- 24.6 in the group with PTSD+depression, and 66.8 +/- 34.6 in healthy controls. The first three groups suppressed significantly more than the fourth. When the number of traumas was introduced as a covariate, the differences disappeared. The hypothesis was confirmed: in respect to DST, the examined trauma-related psychopathologies showed the same pattern: hypersuppression, due to multiple traumatic experiences. (C) 2012 Elsevier Ltd. All rights reserved.",
journal = "Psychoneuroendocrinology",
title = "Is there a biological difference between trauma-related depression and PTSD? DST says NO",
volume = "37",
number = "9",
pages = "1516-1520",
doi = "10.1016/j.psyneuen.2012.02.005"
}

Savić, D. A., Knežević, G., Damjanović, S. S., Spiric, Z.,& Matić, G.. (2012). Is there a biological difference between trauma-related depression and PTSD? DST says NO. in Psychoneuroendocrinology, 37(9), 1516-1520.
https://doi.org/10.1016/j.psyneuen.2012.02.005

Savić DA, Knežević G, Damjanović SS, Spiric Z, Matić G. Is there a biological difference between trauma-related depression and PTSD? DST says NO. in Psychoneuroendocrinology. 2012;37(9):1516-1520.
doi:10.1016/j.psyneuen.2012.02.005 .

Savić, Danka A., Knežević, Goran, Damjanović, Svetozar S., Spiric, Zeljko, Matić, Gordana, "Is there a biological difference between trauma-related depression and PTSD? DST says NO" in Psychoneuroendocrinology, 37, no. 9 (2012):1516-1520,
https://doi.org/10.1016/j.psyneuen.2012.02.005 . .

TY  - JOUR
AU  - Savić, Danka A.
AU  - Jelić, Smiljana
AU  - Buric, Nikola
PY  - 2006
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/3139
AB  - Most of the systems in an organism (human included) function in a regular daily rhythm. Hypothalamo-pituitary-adrenocortical (HPA) axis, although mostly known for its role in stress response, probably has a role in conveying rhythmic signals from the major pacemaker, suprachiazmatic nucleus (SCN), to the periphery. A general qualitative nonphenomenological mathematical model of the HPA axis is constructed and its dynamics is examined using linear stability analysis and Roushes theorem. The results show that this system is asymptotically stable, i.e. it does not generate circadian oscillations, but only responds to the external pacemaker.
T2  - International Journal of Bifurcation and Chaos
T1  - Stability of a general delay differential model of the hypothalamo-pituitary-adrenocortical system
VL  - 16
IS  - 10
SP  - 3079
EP  - 3085
DO  - 10.1142/S0218127406016665
ER  - 

@article{
author = "Savić, Danka A. and Jelić, Smiljana and Buric, Nikola",
year = "2006",
abstract = "Most of the systems in an organism (human included) function in a regular daily rhythm. Hypothalamo-pituitary-adrenocortical (HPA) axis, although mostly known for its role in stress response, probably has a role in conveying rhythmic signals from the major pacemaker, suprachiazmatic nucleus (SCN), to the periphery. A general qualitative nonphenomenological mathematical model of the HPA axis is constructed and its dynamics is examined using linear stability analysis and Roushes theorem. The results show that this system is asymptotically stable, i.e. it does not generate circadian oscillations, but only responds to the external pacemaker.",
journal = "International Journal of Bifurcation and Chaos",
title = "Stability of a general delay differential model of the hypothalamo-pituitary-adrenocortical system",
volume = "16",
number = "10",
pages = "3079-3085",
doi = "10.1142/S0218127406016665"
}

Savić, D. A., Jelić, S.,& Buric, N.. (2006). Stability of a general delay differential model of the hypothalamo-pituitary-adrenocortical system. in International Journal of Bifurcation and Chaos, 16(10), 3079-3085.
https://doi.org/10.1142/S0218127406016665

Savić DA, Jelić S, Buric N. Stability of a general delay differential model of the hypothalamo-pituitary-adrenocortical system. in International Journal of Bifurcation and Chaos. 2006;16(10):3079-3085.
doi:10.1142/S0218127406016665 .

Savić, Danka A., Jelić, Smiljana, Buric, Nikola, "Stability of a general delay differential model of the hypothalamo-pituitary-adrenocortical system" in International Journal of Bifurcation and Chaos, 16, no. 10 (2006):3079-3085,
https://doi.org/10.1142/S0218127406016665 . .

TY  - JOUR
AU  - Savić, Danka A.
AU  - Jelić, Smiljana
PY  - 2005
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/2898
AB  - It is commonly assumed that the hypothalamo-pituitary-adrenocorticat (HPA) axis generates oscillations, because a regular daily rhythm of its component hormones is observed. We offer another plausible explanation of the origin of its circadian oscillations: HPA just responds to an independent external pacemaker (from the suprachiazmatic nucleus, SCN). Five versions (with and without time delay) of a qualitative non-phenomenological mathematical model of the HPA axis as a feedback mechanism are constructed wherein all the terms in the equations are introduced according to the rules of chemical kinetics, i.e. are physicochemically interpretable. The dynamics of the HPA axis model was examined using linear stability analysis. The results show stability of this system, meaning that it does not generate diurnal oscillations. Computer simulation based on this model shows oscillations that are systems response to an external pulsing activator (SCN) implying that the observed time-periodic pattern does not have to be an intrinsic property of the HPA axis. (c) 2005 Elsevier Ltd. All rights reserved.
T2  - Chaos, Solitons and Fractals
T1  - A mathematical model of the hypothalamo-pituitary-adrenocortical system and its stability analysis
VL  - 26
IS  - 2
SP  - 427
EP  - 436
DO  - 10.1016/j.chaos.2005.01.013
ER  - 

@article{
author = "Savić, Danka A. and Jelić, Smiljana",
year = "2005",
abstract = "It is commonly assumed that the hypothalamo-pituitary-adrenocorticat (HPA) axis generates oscillations, because a regular daily rhythm of its component hormones is observed. We offer another plausible explanation of the origin of its circadian oscillations: HPA just responds to an independent external pacemaker (from the suprachiazmatic nucleus, SCN). Five versions (with and without time delay) of a qualitative non-phenomenological mathematical model of the HPA axis as a feedback mechanism are constructed wherein all the terms in the equations are introduced according to the rules of chemical kinetics, i.e. are physicochemically interpretable. The dynamics of the HPA axis model was examined using linear stability analysis. The results show stability of this system, meaning that it does not generate diurnal oscillations. Computer simulation based on this model shows oscillations that are systems response to an external pulsing activator (SCN) implying that the observed time-periodic pattern does not have to be an intrinsic property of the HPA axis. (c) 2005 Elsevier Ltd. All rights reserved.",
journal = "Chaos, Solitons and Fractals",
title = "A mathematical model of the hypothalamo-pituitary-adrenocortical system and its stability analysis",
volume = "26",
number = "2",
pages = "427-436",
doi = "10.1016/j.chaos.2005.01.013"
}

Savić, D. A.,& Jelić, S.. (2005). A mathematical model of the hypothalamo-pituitary-adrenocortical system and its stability analysis. in Chaos, Solitons and Fractals, 26(2), 427-436.
https://doi.org/10.1016/j.chaos.2005.01.013

Savić DA, Jelić S. A mathematical model of the hypothalamo-pituitary-adrenocortical system and its stability analysis. in Chaos, Solitons and Fractals. 2005;26(2):427-436.
doi:10.1016/j.chaos.2005.01.013 .

Savić, Danka A., Jelić, Smiljana, "A mathematical model of the hypothalamo-pituitary-adrenocortical system and its stability analysis" in Chaos, Solitons and Fractals, 26, no. 2 (2005):427-436,
https://doi.org/10.1016/j.chaos.2005.01.013 . .

TY  - JOUR
AU  - Savić, Danka A.
AU  - Jelić, Smiljana
PY  - 2005
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/6555
AB  - Does the hypothalamo-pituitary-adrenocortical (HPA) axis itself generate oscillations? The affirmative answer to this question is commonly assumed, because a regular daily rhythm of its hormones is observed. We offer another plausible explanation of the origin of this pattern: HPA just responds to an external pacemaker. A qualitative mathematical model is constructed wherein all the terms in the equations are physicochemically interpretable. Linear stability analysis shows that this system does not generate oscillations. Computer simulation yields oscillations that are the systems response to an external pulsing activator, implying that the observed pattern does not have to be an intrinsic property of this system.
T2  - Annals of the New York Academy of Sciences
T1  - A theoretical study-of hypothalamo-pituitary adrenocortical axis dynamics
VL  - 1048
SP  - 430
EP  - 432
DO  - 10.1196/annals.1342.055
ER  - 

@article{
author = "Savić, Danka A. and Jelić, Smiljana",
year = "2005",
abstract = "Does the hypothalamo-pituitary-adrenocortical (HPA) axis itself generate oscillations? The affirmative answer to this question is commonly assumed, because a regular daily rhythm of its hormones is observed. We offer another plausible explanation of the origin of this pattern: HPA just responds to an external pacemaker. A qualitative mathematical model is constructed wherein all the terms in the equations are physicochemically interpretable. Linear stability analysis shows that this system does not generate oscillations. Computer simulation yields oscillations that are the systems response to an external pulsing activator, implying that the observed pattern does not have to be an intrinsic property of this system.",
journal = "Annals of the New York Academy of Sciences",
title = "A theoretical study-of hypothalamo-pituitary adrenocortical axis dynamics",
volume = "1048",
pages = "430-432",
doi = "10.1196/annals.1342.055"
}

Savić, D. A.,& Jelić, S.. (2005). A theoretical study-of hypothalamo-pituitary adrenocortical axis dynamics. in Annals of the New York Academy of Sciences, 1048, 430-432.
https://doi.org/10.1196/annals.1342.055

Savić DA, Jelić S. A theoretical study-of hypothalamo-pituitary adrenocortical axis dynamics. in Annals of the New York Academy of Sciences. 2005;1048:430-432.
doi:10.1196/annals.1342.055 .

Savić, Danka A., Jelić, Smiljana, "A theoretical study-of hypothalamo-pituitary adrenocortical axis dynamics" in Annals of the New York Academy of Sciences, 1048 (2005):430-432,
https://doi.org/10.1196/annals.1342.055 . .

TY  - CONF
AU  - Jovic, V
AU  - Lecic-Tosevski, D
AU  - Savić, Danka A.
AU  - Knežević, Goran
AU  - Tenjovic, L
AU  - Opacic, G
PY  - 2000
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/2394
C3  - European Psychiatry
T1  - Quantitative assessment of war-related stressors and a level of distress: A pilot study
VL  - 15
SP  - 449S
EP  - 450S
DO  - 10.1016/S0924-9338(00)94876-4
ER  - 

@conference{
author = "Jovic, V and Lecic-Tosevski, D and Savić, Danka A. and Knežević, Goran and Tenjovic, L and Opacic, G",
year = "2000",
journal = "European Psychiatry",
title = "Quantitative assessment of war-related stressors and a level of distress: A pilot study",
volume = "15",
pages = "449S-450S",
doi = "10.1016/S0924-9338(00)94876-4"
}

Jovic, V., Lecic-Tosevski, D., Savić, D. A., Knežević, G., Tenjovic, L.,& Opacic, G.. (2000). Quantitative assessment of war-related stressors and a level of distress: A pilot study. in European Psychiatry, 15, 449S-450S.
https://doi.org/10.1016/S0924-9338(00)94876-4

Jovic V, Lecic-Tosevski D, Savić DA, Knežević G, Tenjovic L, Opacic G. Quantitative assessment of war-related stressors and a level of distress: A pilot study. in European Psychiatry. 2000;15:449S-450S.
doi:10.1016/S0924-9338(00)94876-4 .

Jovic, V, Lecic-Tosevski, D, Savić, Danka A., Knežević, Goran, Tenjovic, L, Opacic, G, "Quantitative assessment of war-related stressors and a level of distress: A pilot study" in European Psychiatry, 15 (2000):449S-450S,
https://doi.org/10.1016/S0924-9338(00)94876-4 . .

TY  - JOUR
AU  - Savić, Danka A.
AU  - Knežević, Goran
AU  - Opacic, G
PY  - 2000
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/2410
AB  - People differ in what they experience as stressful and to what extent. We define a variable-stress threshold (sigma)-that links the hypothalamo-pituitary-adrenocortical (HPA) axis and the memory system in a feedback mechanism. Current sigma dictates the intensity of a stimulus that turns the stress response on. On the other hand, each jump of the HPA axis helps long-term registration of the stressful event via concentration changes of some of its products, consequently changing the value of sigma for future stressors. After the action of a strong exterior stressor, the new stressful memory acts as an internal source of stress. We assume that its intensity decreases with the rate of processing the stressful information. This process is characterized by a time parameter tau. Both sigma and tau are individual: They depend on personality traits, genetic as well as acquired. The mathematical model presented here simulates the feedback mechanism between the HPA axis and the memory system involved in stress reaction.
T2  - Psychobiology
T1  - A mathematical model of stress reaction: Individual differences in threshold and duration
VL  - 28
IS  - 4
SP  - 581
EP  - 592
UR  - https://hdl.handle.net/21.15107/rcub_vinar_2410
ER  - 

@article{
author = "Savić, Danka A. and Knežević, Goran and Opacic, G",
year = "2000",
abstract = "People differ in what they experience as stressful and to what extent. We define a variable-stress threshold (sigma)-that links the hypothalamo-pituitary-adrenocortical (HPA) axis and the memory system in a feedback mechanism. Current sigma dictates the intensity of a stimulus that turns the stress response on. On the other hand, each jump of the HPA axis helps long-term registration of the stressful event via concentration changes of some of its products, consequently changing the value of sigma for future stressors. After the action of a strong exterior stressor, the new stressful memory acts as an internal source of stress. We assume that its intensity decreases with the rate of processing the stressful information. This process is characterized by a time parameter tau. Both sigma and tau are individual: They depend on personality traits, genetic as well as acquired. The mathematical model presented here simulates the feedback mechanism between the HPA axis and the memory system involved in stress reaction.",
journal = "Psychobiology",
title = "A mathematical model of stress reaction: Individual differences in threshold and duration",
volume = "28",
number = "4",
pages = "581-592",
url = "https://hdl.handle.net/21.15107/rcub_vinar_2410"
}

Savić, D. A., Knežević, G.,& Opacic, G.. (2000). A mathematical model of stress reaction: Individual differences in threshold and duration. in Psychobiology, 28(4), 581-592.
https://hdl.handle.net/21.15107/rcub_vinar_2410

Savić DA, Knežević G, Opacic G. A mathematical model of stress reaction: Individual differences in threshold and duration. in Psychobiology. 2000;28(4):581-592.
https://hdl.handle.net/21.15107/rcub_vinar_2410 .

Savić, Danka A., Knežević, Goran, Opacic, G, "A mathematical model of stress reaction: Individual differences in threshold and duration" in Psychobiology, 28, no. 4 (2000):581-592,
https://hdl.handle.net/21.15107/rcub_vinar_2410 .