TY  - JOUR
AU  - Željić, Katarina
AU  - Jovanović, Ivan G.
AU  - Jovanović, Jasmina
AU  - Magić, Zvonko
AU  - Stanković, Aleksandra
AU  - Šupić, Gordana
PY  - 2018
UR  - https://www.tandfonline.com/doi/full/10.1080/03009734.2018.1439551
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/7630
AB  - Aim: It was the aim of the study to identify commonly deregulated miRNAs in oral cancer patients by performing a meta-analysis of previously published miRNA expression profiles in cancer and matched normal non-cancerous tissue in such patients. Material and methods: Meta-analysis included seven independent studies analyzed by a vote-counting method followed by bioinformatic enrichment analysis. Results: Amongst seven independent studies included in the meta-analysis, 20 miRNAs were found to be deregulated in oral cancer when compared with non-cancerous tissue. Eleven miRNAs were consistently up-regulated in three or more studies (miR-21-5p, miR-31-5p, miR-135b-5p, miR-31-3p, miR-93-5p, miR-34b-5p, miR-424-5p, miR-18a-5p, miR-455-3p, miR-450a-5p, miR-21-3p), and nine were down-regulated (miR-139-5p, miR-30a-3p, miR-376c-3p, miR-885-5p, miR-375, miR-486-5p, miR-411-5p, miR-133a-3p, miR-30a-5p). The meta-signature of identified miRNAs was functionally characterized by KEGG enrichment analysis. Twenty-four KEGG pathways were significantly enriched, and TGF-beta signaling was the most enriched signaling pathway. The highest number of meta-signature miRNAs was involved in the sphingolipid signaling pathway. Natural killer cell-mediated cytotoxicity was the pathway with most genes regulated by identified miRNAs. The rest of the enriched pathways in our miRNA list describe different malignancies and signaling. Conclusions: The identified miRNA meta-signature might be considered as a potential battery of biomarkers when distinguishing oral cancer tissue from normal, non-cancerous tissue. Further mechanistic studies are warranted in order to confirm and fully elucidate the role of deregulated miRNAs in oral cancer.
T2  - Upsala Journal of Medical Sciences
T1  - MicroRNA meta-signature of oral cancer: evidence from a meta-analysis
VL  - 123
IS  - 1
SP  - 43
EP  - 49
DO  - 10.1080/03009734.2018.1439551
ER  - 

@article{
author = "Željić, Katarina and Jovanović, Ivan G. and Jovanović, Jasmina and Magić, Zvonko and Stanković, Aleksandra and Šupić, Gordana",
year = "2018",
abstract = "Aim: It was the aim of the study to identify commonly deregulated miRNAs in oral cancer patients by performing a meta-analysis of previously published miRNA expression profiles in cancer and matched normal non-cancerous tissue in such patients. Material and methods: Meta-analysis included seven independent studies analyzed by a vote-counting method followed by bioinformatic enrichment analysis. Results: Amongst seven independent studies included in the meta-analysis, 20 miRNAs were found to be deregulated in oral cancer when compared with non-cancerous tissue. Eleven miRNAs were consistently up-regulated in three or more studies (miR-21-5p, miR-31-5p, miR-135b-5p, miR-31-3p, miR-93-5p, miR-34b-5p, miR-424-5p, miR-18a-5p, miR-455-3p, miR-450a-5p, miR-21-3p), and nine were down-regulated (miR-139-5p, miR-30a-3p, miR-376c-3p, miR-885-5p, miR-375, miR-486-5p, miR-411-5p, miR-133a-3p, miR-30a-5p). The meta-signature of identified miRNAs was functionally characterized by KEGG enrichment analysis. Twenty-four KEGG pathways were significantly enriched, and TGF-beta signaling was the most enriched signaling pathway. The highest number of meta-signature miRNAs was involved in the sphingolipid signaling pathway. Natural killer cell-mediated cytotoxicity was the pathway with most genes regulated by identified miRNAs. The rest of the enriched pathways in our miRNA list describe different malignancies and signaling. Conclusions: The identified miRNA meta-signature might be considered as a potential battery of biomarkers when distinguishing oral cancer tissue from normal, non-cancerous tissue. Further mechanistic studies are warranted in order to confirm and fully elucidate the role of deregulated miRNAs in oral cancer.",
journal = "Upsala Journal of Medical Sciences",
title = "MicroRNA meta-signature of oral cancer: evidence from a meta-analysis",
volume = "123",
number = "1",
pages = "43-49",
doi = "10.1080/03009734.2018.1439551"
}

Željić, K., Jovanović, I. G., Jovanović, J., Magić, Z., Stanković, A.,& Šupić, G.. (2018). MicroRNA meta-signature of oral cancer: evidence from a meta-analysis. in Upsala Journal of Medical Sciences, 123(1), 43-49.
https://doi.org/10.1080/03009734.2018.1439551

Željić K, Jovanović IG, Jovanović J, Magić Z, Stanković A, Šupić G. MicroRNA meta-signature of oral cancer: evidence from a meta-analysis. in Upsala Journal of Medical Sciences. 2018;123(1):43-49.
doi:10.1080/03009734.2018.1439551 .

Željić, Katarina, Jovanović, Ivan G., Jovanović, Jasmina, Magić, Zvonko, Stanković, Aleksandra, Šupić, Gordana, "MicroRNA meta-signature of oral cancer: evidence from a meta-analysis" in Upsala Journal of Medical Sciences, 123, no. 1 (2018):43-49,
https://doi.org/10.1080/03009734.2018.1439551 . .