TY  - JOUR
AU  - Maksimović, Tijana V.
AU  - Maksimović, Jelena P.
AU  - Tančić, Pavle I.
AU  - Potkonjak, Nebojša I.
AU  - Nedić, Zoran P.
AU  - Joksović, Ljubinka G.
AU  - Pagnacco, Maja C.
PY  - 2021
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/9878
AB  - The calcium phosphate tungsten bronze (Ca-PWB) has been synthesized and characterized (TGA, DSC, XRPD, FTIR, SEM). The influence of solid insoluble materials Ca-PWB, as well as lithium doped (Li-PWB) and cation free phosphate tungsten (PWB) bronzes on the oscillatory Briggs-Rauscher (BR) reaction dynamics, is compared. The results show that doping with Li and Ca reduces sensitivity of the BR reaction towards bronzes addition. These findings suggest the usage of the BR reaction as an innovative method for testing of different properties of bronze material. The behavior of PWB in the BR reaction is significantly changed with divalent cation (Ca2+) doping. The reasons for the different bronzes behavior were found in their calculated unit cell volumes. Namely, the compressed Ca-PWB unit cell volume indicates the difficult availability of the active site for heterogeneous catalysis. Hence, the linear correlation (slope) of the BR oscillogram’s length (τosc) vs. mass of bronze in BR reaction might be considered as a new parameter for the evaluation of the bronzes catalytic activity.
T2  - Science of Sintering
T1  - A possible connection between phosphate tungsten bronzes properties and briggs-rauscher oscillatory reaction response
VL  - 53
IS  - 2
SP  - 223
EP  - 235
DO  - 10.2298/SOS2102223M
ER  - 

@article{
author = "Maksimović, Tijana V. and Maksimović, Jelena P. and Tančić, Pavle I. and Potkonjak, Nebojša I. and Nedić, Zoran P. and Joksović, Ljubinka G. and Pagnacco, Maja C.",
year = "2021",
abstract = "The calcium phosphate tungsten bronze (Ca-PWB) has been synthesized and characterized (TGA, DSC, XRPD, FTIR, SEM). The influence of solid insoluble materials Ca-PWB, as well as lithium doped (Li-PWB) and cation free phosphate tungsten (PWB) bronzes on the oscillatory Briggs-Rauscher (BR) reaction dynamics, is compared. The results show that doping with Li and Ca reduces sensitivity of the BR reaction towards bronzes addition. These findings suggest the usage of the BR reaction as an innovative method for testing of different properties of bronze material. The behavior of PWB in the BR reaction is significantly changed with divalent cation (Ca2+) doping. The reasons for the different bronzes behavior were found in their calculated unit cell volumes. Namely, the compressed Ca-PWB unit cell volume indicates the difficult availability of the active site for heterogeneous catalysis. Hence, the linear correlation (slope) of the BR oscillogram’s length (τosc) vs. mass of bronze in BR reaction might be considered as a new parameter for the evaluation of the bronzes catalytic activity.",
journal = "Science of Sintering",
title = "A possible connection between phosphate tungsten bronzes properties and briggs-rauscher oscillatory reaction response",
volume = "53",
number = "2",
pages = "223-235",
doi = "10.2298/SOS2102223M"
}

Maksimović, T. V., Maksimović, J. P., Tančić, P. I., Potkonjak, N. I., Nedić, Z. P., Joksović, L. G.,& Pagnacco, M. C.. (2021). A possible connection between phosphate tungsten bronzes properties and briggs-rauscher oscillatory reaction response. in Science of Sintering, 53(2), 223-235.
https://doi.org/10.2298/SOS2102223M

Maksimović TV, Maksimović JP, Tančić PI, Potkonjak NI, Nedić ZP, Joksović LG, Pagnacco MC. A possible connection between phosphate tungsten bronzes properties and briggs-rauscher oscillatory reaction response. in Science of Sintering. 2021;53(2):223-235.
doi:10.2298/SOS2102223M .

Maksimović, Tijana V., Maksimović, Jelena P., Tančić, Pavle I., Potkonjak, Nebojša I., Nedić, Zoran P., Joksović, Ljubinka G., Pagnacco, Maja C., "A possible connection between phosphate tungsten bronzes properties and briggs-rauscher oscillatory reaction response" in Science of Sintering, 53, no. 2 (2021):223-235,
https://doi.org/10.2298/SOS2102223M . .

TY  - JOUR
AU  - Cvijović, Mirjana R.
AU  - Di Marco, Valerio
AU  - Stanković, Srboljub
AU  - Nedić, Zoran P.
AU  - Joksović, Ljubinka G.
AU  - Mihailović, Nevena R.
PY  - 2019
UR  - https://journals.matheo.si/index.php/ACSi/article/view/4468
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/8088
AB  - Chlorpyrifos (CPS) is a toxic pesticide present in several pesticide formulations, with low degradability by natural processes. The degradation leads to the toxic metabolite chlorpyrifos-oxon (CPO). The analytical techniques used for the CPS and CPO analysis, like UPLC-PDA and GC-MS, are accurate but also expensive and time consuming, and they need sample pretreatment. In the search of a more rapid and simple analytical procedure, atmospheric solids analysis probe with mass spectrometry (ASAP-MS) was optimized for the determination of CPS and CPO in apples (Malus domestica „Idared”). The identification of the analytes was based on protonated ion and isotopic pattern, while the quantification was based on peak intensities. The obtained results were confirmed by re-validated UPLC-PDA and GC-MS techniques. CPS and CPO concentrations determined by ASAP-MS and UPLC-PDA showed moderate discrepancies (on average by 10–20%), thus demonstrating that ASAP-MS can be a semiquantitative tool for the quantification of these compounds. As additional goal of this work, the efficiency of a gamma irradiation treatment to remove CPS and CPO from apples was tested by analyzing their content before and after the irradiation: 89–99% of CPS and CPO were degraded with doses of 3.5–3.8 kGy and 66–72 h of irradiation per sample. Identical degradation results were obtained by UPLC-PDA and ASAP-MS, indicating that the latter technique is well suitable to rapidly check pesticide degradation in apples. © 2019 Slovensko Kemijsko Drustvo. All Rights Reserved.
T2  - Acta Chimica Slovenica
T1  - Atmospheric Solids Analysis Probe with Mass Spectrometry for Chlorpyrifos and Chlorpyrifos-Oxon Determination in Apples
VL  - 66
IS  - 1
SP  - 70
EP  - 77
DO  - 10.17344/acsi.2018.4468
ER  - 

@article{
author = "Cvijović, Mirjana R. and Di Marco, Valerio and Stanković, Srboljub and Nedić, Zoran P. and Joksović, Ljubinka G. and Mihailović, Nevena R.",
year = "2019",
abstract = "Chlorpyrifos (CPS) is a toxic pesticide present in several pesticide formulations, with low degradability by natural processes. The degradation leads to the toxic metabolite chlorpyrifos-oxon (CPO). The analytical techniques used for the CPS and CPO analysis, like UPLC-PDA and GC-MS, are accurate but also expensive and time consuming, and they need sample pretreatment. In the search of a more rapid and simple analytical procedure, atmospheric solids analysis probe with mass spectrometry (ASAP-MS) was optimized for the determination of CPS and CPO in apples (Malus domestica „Idared”). The identification of the analytes was based on protonated ion and isotopic pattern, while the quantification was based on peak intensities. The obtained results were confirmed by re-validated UPLC-PDA and GC-MS techniques. CPS and CPO concentrations determined by ASAP-MS and UPLC-PDA showed moderate discrepancies (on average by 10–20%), thus demonstrating that ASAP-MS can be a semiquantitative tool for the quantification of these compounds. As additional goal of this work, the efficiency of a gamma irradiation treatment to remove CPS and CPO from apples was tested by analyzing their content before and after the irradiation: 89–99% of CPS and CPO were degraded with doses of 3.5–3.8 kGy and 66–72 h of irradiation per sample. Identical degradation results were obtained by UPLC-PDA and ASAP-MS, indicating that the latter technique is well suitable to rapidly check pesticide degradation in apples. © 2019 Slovensko Kemijsko Drustvo. All Rights Reserved.",
journal = "Acta Chimica Slovenica",
title = "Atmospheric Solids Analysis Probe with Mass Spectrometry for Chlorpyrifos and Chlorpyrifos-Oxon Determination in Apples",
volume = "66",
number = "1",
pages = "70-77",
doi = "10.17344/acsi.2018.4468"
}

Cvijović, M. R., Di Marco, V., Stanković, S., Nedić, Z. P., Joksović, L. G.,& Mihailović, N. R.. (2019). Atmospheric Solids Analysis Probe with Mass Spectrometry for Chlorpyrifos and Chlorpyrifos-Oxon Determination in Apples. in Acta Chimica Slovenica, 66(1), 70-77.
https://doi.org/10.17344/acsi.2018.4468

Cvijović MR, Di Marco V, Stanković S, Nedić ZP, Joksović LG, Mihailović NR. Atmospheric Solids Analysis Probe with Mass Spectrometry for Chlorpyrifos and Chlorpyrifos-Oxon Determination in Apples. in Acta Chimica Slovenica. 2019;66(1):70-77.
doi:10.17344/acsi.2018.4468 .

Cvijović, Mirjana R., Di Marco, Valerio, Stanković, Srboljub, Nedić, Zoran P., Joksović, Ljubinka G., Mihailović, Nevena R., "Atmospheric Solids Analysis Probe with Mass Spectrometry for Chlorpyrifos and Chlorpyrifos-Oxon Determination in Apples" in Acta Chimica Slovenica, 66, no. 1 (2019):70-77,
https://doi.org/10.17344/acsi.2018.4468 . .

TY  - JOUR
AU  - Jakovljević, Katarina
AU  - Joksović, Milan D.
AU  - Matić, Ivana Z.
AU  - Petrović, Nina
AU  - Stanojković, Tatjana P.
AU  - Sladić, Dušan M.
AU  - Vujčić, Miroslava T.
AU  - Janović, Barbara S.
AU  - Joksović, Ljubinka G.
AU  - Trifunović, Snežana
AU  - Marković, Violeta
PY  - 2018
UR  - http://xlink.rsc.org/?DOI=C8MD00316E
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/7928
AB  - Hybrid compounds that combine the 1,3,4-thiadiazole-containing catechol moiety with a chalcone motif were synthesized and examined for their antioxidant activity, cytotoxicity, and DNA-binding activity. A series of thirteen compounds showed strong antioxidant and cytotoxic effects on human acute promyelocytic leukemia HL-60 cells. Several compounds exerted good cytotoxic activities on cervical adenocarcinoma HeLa cells. The treatment of HeLa cells with IC50 and double IC50 concentrations of the compounds 5a, 5c, 5f, and 5m induced a statistically significant increase in the percentage of cells within a subG1 cell cycle phase. The examined compounds caused G2/M cell cycle arrest in HeLa cells. Each of these compounds triggered apoptosis in HeLa cells through activation of caspase-3, the main effector caspase, caspase-8, which is involved in the extrinsic apoptotic pathway, and caspase-9, which is involved in the intrinsic apoptotic pathway. All of the examined compounds decreased the expression levels of MMP2 in HeLa cells and levels of protumorigenic miR-133b. Compounds 5a and 5m lowered the expression level of oncogenic miR-21 in HeLa cells. In addition, compounds 5a, 5f, and 5m decreased the expression levels of oncogenic miR-155 while the treatment of HeLa cells with compounds 5a, 5c, and 5f increased expression of tumor-suppressive miR-206. Observed effects of these compounds on expression levels of four examined miRNAs suggest their prominent cancer-suppressive activity. An investigation by absorption and fluorescence spectroscopy showed more efficient calf thymus DNA binding activity of the compound 5m in comparison to other tested compounds. Results of a pUC19 plasmid cleavage study and comet assay showed DNA damaging activities of compounds 5a and 5c.
T2  - MedChemComm
T1  - Novel 1,3,4-thiadiazole–chalcone hybrids containing catechol moiety: synthesis, antioxidant activity, cytotoxicity and DNA interaction studies
VL  - 9
IS  - 10
SP  - 1679
EP  - 1697
DO  - 10.1039/C8MD00316E
ER  - 

@article{
author = "Jakovljević, Katarina and Joksović, Milan D. and Matić, Ivana Z. and Petrović, Nina and Stanojković, Tatjana P. and Sladić, Dušan M. and Vujčić, Miroslava T. and Janović, Barbara S. and Joksović, Ljubinka G. and Trifunović, Snežana and Marković, Violeta",
year = "2018",
abstract = "Hybrid compounds that combine the 1,3,4-thiadiazole-containing catechol moiety with a chalcone motif were synthesized and examined for their antioxidant activity, cytotoxicity, and DNA-binding activity. A series of thirteen compounds showed strong antioxidant and cytotoxic effects on human acute promyelocytic leukemia HL-60 cells. Several compounds exerted good cytotoxic activities on cervical adenocarcinoma HeLa cells. The treatment of HeLa cells with IC50 and double IC50 concentrations of the compounds 5a, 5c, 5f, and 5m induced a statistically significant increase in the percentage of cells within a subG1 cell cycle phase. The examined compounds caused G2/M cell cycle arrest in HeLa cells. Each of these compounds triggered apoptosis in HeLa cells through activation of caspase-3, the main effector caspase, caspase-8, which is involved in the extrinsic apoptotic pathway, and caspase-9, which is involved in the intrinsic apoptotic pathway. All of the examined compounds decreased the expression levels of MMP2 in HeLa cells and levels of protumorigenic miR-133b. Compounds 5a and 5m lowered the expression level of oncogenic miR-21 in HeLa cells. In addition, compounds 5a, 5f, and 5m decreased the expression levels of oncogenic miR-155 while the treatment of HeLa cells with compounds 5a, 5c, and 5f increased expression of tumor-suppressive miR-206. Observed effects of these compounds on expression levels of four examined miRNAs suggest their prominent cancer-suppressive activity. An investigation by absorption and fluorescence spectroscopy showed more efficient calf thymus DNA binding activity of the compound 5m in comparison to other tested compounds. Results of a pUC19 plasmid cleavage study and comet assay showed DNA damaging activities of compounds 5a and 5c.",
journal = "MedChemComm",
title = "Novel 1,3,4-thiadiazole–chalcone hybrids containing catechol moiety: synthesis, antioxidant activity, cytotoxicity and DNA interaction studies",
volume = "9",
number = "10",
pages = "1679-1697",
doi = "10.1039/C8MD00316E"
}

Jakovljević, K., Joksović, M. D., Matić, I. Z., Petrović, N., Stanojković, T. P., Sladić, D. M., Vujčić, M. T., Janović, B. S., Joksović, L. G., Trifunović, S.,& Marković, V.. (2018). Novel 1,3,4-thiadiazole–chalcone hybrids containing catechol moiety: synthesis, antioxidant activity, cytotoxicity and DNA interaction studies. in MedChemComm, 9(10), 1679-1697.
https://doi.org/10.1039/C8MD00316E

Jakovljević K, Joksović MD, Matić IZ, Petrović N, Stanojković TP, Sladić DM, Vujčić MT, Janović BS, Joksović LG, Trifunović S, Marković V. Novel 1,3,4-thiadiazole–chalcone hybrids containing catechol moiety: synthesis, antioxidant activity, cytotoxicity and DNA interaction studies. in MedChemComm. 2018;9(10):1679-1697.
doi:10.1039/C8MD00316E .

Jakovljević, Katarina, Joksović, Milan D., Matić, Ivana Z., Petrović, Nina, Stanojković, Tatjana P., Sladić, Dušan M., Vujčić, Miroslava T., Janović, Barbara S., Joksović, Ljubinka G., Trifunović, Snežana, Marković, Violeta, "Novel 1,3,4-thiadiazole–chalcone hybrids containing catechol moiety: synthesis, antioxidant activity, cytotoxicity and DNA interaction studies" in MedChemComm, 9, no. 10 (2018):1679-1697,
https://doi.org/10.1039/C8MD00316E . .

TY  - JOUR
AU  - Petrović, Đorđe
AU  - Jakovljević, Ivan
AU  - Joksović, Ljubinka G.
AU  - Szecsenyi, Katalin Meszaros
AU  - Durdevic, Predrag
PY  - 2016
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/276
AB  - Hydrolysis reactions of YCl3 aqueous solutions were studied by potentiometric titrations at 310 K in the pH range ca.3-9 and total Y3+ ion concentration range 0.5-10.0 mmol/dm(3). The experimental data were evaluated with the aid of the Hyperquad2006 suite of programs, which indicated the formation of the following hydrolytic complexes (log conc. overall stability constants beta(p,q) defined as beta(p,q) = M-p(OH)(q)[H](q)/[M](p)), Y(OH)(2+) (-7.71(2)); Y(OH)(2)(+) (-16.42(2)); Y(OH)(3) (-26.01(3)); Y-2(OH)(2)(4+) (-14.23(4)); Y-3(OH)(5)(2+) (-34.20 (4)); Y-4(OH)(6)(2+) (-37.10(5)). The hydrolysis of the Y3+ ion was also monitored by electrospray ionization ion-trap mass spectrometry (ESI-MS) in the pH range 2.63-7.10. The influence of the sample cone voltage on the product distribution was significant, indicating the contribution of ion source fragmentation reactions. The optimal cone voltage was set to 70 V for cationic and 100 V for anionic spectra. The cationic and anionic ESI mass spectra of the Y3+ solutions produced strong evidence for the presence of a variety of monomeric and polymeric hydrolytic complexes. The Cl- ion appeared to be a strong competitor to the OH- ion for the oxo-yttrium core. The hydrolytic precipitation reactions with NaOH or urea as precipitating agents were studied. The obtained precipitates were characterized by the potentiometric technique, elemental analysis, thermal analysis (TG-DSC), infrared spectroscopy, X-ray diffractions and the SEM technique. Hydrothermal synthesis of the precipitate in an autoclave at T= 420 K and P = 10 bar with NaOH as the precipitating agent produced a crystalline precipitate in the form of hexagonal needles (P6(3)/m space group). At atmospheric pressure only an amorphous precipitate was produced with both precipitating agents. The concentration solubility product K-so* of Y(OH)(3) was evaluated from the potentiometric titrations curves and logK(so)* = -22.85(4). The synthesized precipitate with NaOH as a precipitating agent had a composition of Y(OH)(3)center dot 2H(2)O, while the amorphous precipitate obtained with urea had a composition of Y-2(OH)(2)(CO3)(2)center dot 3H(2)O. (C) 2015 Elsevier Ltd. All rights reserved.
T2  - Polyhedron
T1  - Study of the hydrolytic properties of the trivalent Y-ion in chloride medium
VL  - 105
SP  - 1
EP  - 11
DO  - 10.1016/j.poly.2015.11.047
ER  - 

@article{
author = "Petrović, Đorđe and Jakovljević, Ivan and Joksović, Ljubinka G. and Szecsenyi, Katalin Meszaros and Durdevic, Predrag",
year = "2016",
abstract = "Hydrolysis reactions of YCl3 aqueous solutions were studied by potentiometric titrations at 310 K in the pH range ca.3-9 and total Y3+ ion concentration range 0.5-10.0 mmol/dm(3). The experimental data were evaluated with the aid of the Hyperquad2006 suite of programs, which indicated the formation of the following hydrolytic complexes (log conc. overall stability constants beta(p,q) defined as beta(p,q) = M-p(OH)(q)[H](q)/[M](p)), Y(OH)(2+) (-7.71(2)); Y(OH)(2)(+) (-16.42(2)); Y(OH)(3) (-26.01(3)); Y-2(OH)(2)(4+) (-14.23(4)); Y-3(OH)(5)(2+) (-34.20 (4)); Y-4(OH)(6)(2+) (-37.10(5)). The hydrolysis of the Y3+ ion was also monitored by electrospray ionization ion-trap mass spectrometry (ESI-MS) in the pH range 2.63-7.10. The influence of the sample cone voltage on the product distribution was significant, indicating the contribution of ion source fragmentation reactions. The optimal cone voltage was set to 70 V for cationic and 100 V for anionic spectra. The cationic and anionic ESI mass spectra of the Y3+ solutions produced strong evidence for the presence of a variety of monomeric and polymeric hydrolytic complexes. The Cl- ion appeared to be a strong competitor to the OH- ion for the oxo-yttrium core. The hydrolytic precipitation reactions with NaOH or urea as precipitating agents were studied. The obtained precipitates were characterized by the potentiometric technique, elemental analysis, thermal analysis (TG-DSC), infrared spectroscopy, X-ray diffractions and the SEM technique. Hydrothermal synthesis of the precipitate in an autoclave at T= 420 K and P = 10 bar with NaOH as the precipitating agent produced a crystalline precipitate in the form of hexagonal needles (P6(3)/m space group). At atmospheric pressure only an amorphous precipitate was produced with both precipitating agents. The concentration solubility product K-so* of Y(OH)(3) was evaluated from the potentiometric titrations curves and logK(so)* = -22.85(4). The synthesized precipitate with NaOH as a precipitating agent had a composition of Y(OH)(3)center dot 2H(2)O, while the amorphous precipitate obtained with urea had a composition of Y-2(OH)(2)(CO3)(2)center dot 3H(2)O. (C) 2015 Elsevier Ltd. All rights reserved.",
journal = "Polyhedron",
title = "Study of the hydrolytic properties of the trivalent Y-ion in chloride medium",
volume = "105",
pages = "1-11",
doi = "10.1016/j.poly.2015.11.047"
}

Petrović, Đ., Jakovljević, I., Joksović, L. G., Szecsenyi, K. M.,& Durdevic, P.. (2016). Study of the hydrolytic properties of the trivalent Y-ion in chloride medium. in Polyhedron, 105, 1-11.
https://doi.org/10.1016/j.poly.2015.11.047

Petrović Đ, Jakovljević I, Joksović LG, Szecsenyi KM, Durdevic P. Study of the hydrolytic properties of the trivalent Y-ion in chloride medium. in Polyhedron. 2016;105:1-11.
doi:10.1016/j.poly.2015.11.047 .

Petrović, Đorđe, Jakovljević, Ivan, Joksović, Ljubinka G., Szecsenyi, Katalin Meszaros, Durdevic, Predrag, "Study of the hydrolytic properties of the trivalent Y-ion in chloride medium" in Polyhedron, 105 (2016):1-11,
https://doi.org/10.1016/j.poly.2015.11.047 . .

TY  - JOUR
AU  - Jakovljević, Ivan
AU  - Petrović, Đorđe
AU  - Joksović, Ljubinka G.
AU  - Lazarević, Ivan
AU  - Jelikić-Stankov, Milena
AU  - Đurđević, Predrag
PY  - 2015
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/833
AB  - Complex formation equilibria of aluminum(III), gadolinium(III), and yttrium(III) ions with the fluoroquinolone antibacterials moxifloxacin, ofloxacin, fleroxacin, lomefloxacin, levofloxacin, and ciprofloxacin were studied in aqueous solution by potentiometric and spectroscopic methods. The identity and stability of metal-fluoroquinolone complexes were determined by analyzing potentiometric titration curves (310K, =0.15M NaCl, pH range=2-11, C-L/C-M=1:1 to 3:1, C-M=1.0mM) with the aid of Hyperquad2006 program. The main species formed in the system may be formulated as MpHqLr (p=1, q=-2 to 2, r=1-3, L=fluoroquinolone anion, logarithm of overall stability constant, log (p,q,r)=in the range ca. -10 to 45). The stability of complexes is mostly influenced by metal ion properties (ionization potential, ionic radius) indicating partial ionic character of the coordination bond. The complexes were also characterized by spectroscopic measurements: spectrofluorimetry, H-1-NMR, and ESI-MS. Fluorimetric data were evaluated with the aid of HypSpec2014 and indicated the formation of MLr (r=1-3) complexes with cumulative conditional stability constants significantly lower than the thermodynamic ones. NMR and MS data corroborate potentiometrically determined speciation. Calculated plasma mobilizing capacity of the ligands generally follows the order levofloxacin GT moxifloxacin GT ciprofloxacin at concentration levels of the ligands higher or equal to ca. 10(-4)M.
PB  - Taylor & Francis
T2  - Journal of Coordination Chemistry
T1  - Complex formation equilibria between aluminum(III), gadolinium(III) and yttrium(III) ions and some fluoroquinolone ligands. Potentiometric and spectroscopic study
VL  - 68
IS  - 24
SP  - 4272
EP  - 4295
DO  - 10.1080/00958972.2015.1089535
ER  - 

@article{
author = "Jakovljević, Ivan and Petrović, Đorđe and Joksović, Ljubinka G. and Lazarević, Ivan and Jelikić-Stankov, Milena and Đurđević, Predrag",
year = "2015",
abstract = "Complex formation equilibria of aluminum(III), gadolinium(III), and yttrium(III) ions with the fluoroquinolone antibacterials moxifloxacin, ofloxacin, fleroxacin, lomefloxacin, levofloxacin, and ciprofloxacin were studied in aqueous solution by potentiometric and spectroscopic methods. The identity and stability of metal-fluoroquinolone complexes were determined by analyzing potentiometric titration curves (310K, =0.15M NaCl, pH range=2-11, C-L/C-M=1:1 to 3:1, C-M=1.0mM) with the aid of Hyperquad2006 program. The main species formed in the system may be formulated as MpHqLr (p=1, q=-2 to 2, r=1-3, L=fluoroquinolone anion, logarithm of overall stability constant, log (p,q,r)=in the range ca. -10 to 45). The stability of complexes is mostly influenced by metal ion properties (ionization potential, ionic radius) indicating partial ionic character of the coordination bond. The complexes were also characterized by spectroscopic measurements: spectrofluorimetry, H-1-NMR, and ESI-MS. Fluorimetric data were evaluated with the aid of HypSpec2014 and indicated the formation of MLr (r=1-3) complexes with cumulative conditional stability constants significantly lower than the thermodynamic ones. NMR and MS data corroborate potentiometrically determined speciation. Calculated plasma mobilizing capacity of the ligands generally follows the order levofloxacin GT moxifloxacin GT ciprofloxacin at concentration levels of the ligands higher or equal to ca. 10(-4)M.",
publisher = "Taylor & Francis",
journal = "Journal of Coordination Chemistry",
title = "Complex formation equilibria between aluminum(III), gadolinium(III) and yttrium(III) ions and some fluoroquinolone ligands. Potentiometric and spectroscopic study",
volume = "68",
number = "24",
pages = "4272-4295",
doi = "10.1080/00958972.2015.1089535"
}

Jakovljević, I., Petrović, Đ., Joksović, L. G., Lazarević, I., Jelikić-Stankov, M.,& Đurđević, P.. (2015). Complex formation equilibria between aluminum(III), gadolinium(III) and yttrium(III) ions and some fluoroquinolone ligands. Potentiometric and spectroscopic study. in Journal of Coordination Chemistry
Taylor & Francis., 68(24), 4272-4295.
https://doi.org/10.1080/00958972.2015.1089535

Jakovljević I, Petrović Đ, Joksović LG, Lazarević I, Jelikić-Stankov M, Đurđević P. Complex formation equilibria between aluminum(III), gadolinium(III) and yttrium(III) ions and some fluoroquinolone ligands. Potentiometric and spectroscopic study. in Journal of Coordination Chemistry. 2015;68(24):4272-4295.
doi:10.1080/00958972.2015.1089535 .

Jakovljević, Ivan, Petrović, Đorđe, Joksović, Ljubinka G., Lazarević, Ivan, Jelikić-Stankov, Milena, Đurđević, Predrag, "Complex formation equilibria between aluminum(III), gadolinium(III) and yttrium(III) ions and some fluoroquinolone ligands. Potentiometric and spectroscopic study" in Journal of Coordination Chemistry, 68, no. 24 (2015):4272-4295,
https://doi.org/10.1080/00958972.2015.1089535 . .

TY  - JOUR
AU  - Jakovljević, Ivan
AU  - Petrović, Đorđe
AU  - Joksović, Ljubinka G.
AU  - Lazarević, Ivan
AU  - Durdevic, Predrag
PY  - 2013
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/5824
AB  - The speciation of Al3+, Gd3+ and Y3+ ions in human plasma has been studied by computer simulation using the program HySS2009. A literature computer model of blood plasma was updated and comprised 9 metals, 43 ligands and over 6100 complexes. To this model critically evaluated data of Al3+, Gd3+ and Y3+ constants with blood plasma ligands have been added. Low molecular mass (LMM) speciation of Al3+ ion strongly depends upon the chosen equilibrium model of the metal - phosphate and metal - citrate systems. The obtained computer simulation of LMM speciation data of Al3+ ion were: AlPO(4)Cit (40.7%), AlPO(4)CitOH (22.9%), AlCitOH (19.2%) and AlPO4(OH) (12.7%) (% of total LMM Al species pool); for Gd3+ ion: GdAspCit (30%) and GdCit(OH)(2) (20%) (% of total [Gd]) and for Y3+ ion: YCit (48%), Y(CO3)(2) (32%) and Y(CO3) (11%) (% of total [Y]). Citrate appears as the important binding and mobilizing ligand for all examined ions, while the dominating species are the ternary ones.
T2  - Acta Chimica Slovenica
T1  - Computer Simulation of Speciation of Trivalent Aluminum, Gadolinium and Yttrium Ions in Human Blood Plasma
VL  - 60
IS  - 4
SP  - 861
EP  - 869
UR  - https://hdl.handle.net/21.15107/rcub_vinar_5824
ER  - 

@article{
author = "Jakovljević, Ivan and Petrović, Đorđe and Joksović, Ljubinka G. and Lazarević, Ivan and Durdevic, Predrag",
year = "2013",
abstract = "The speciation of Al3+, Gd3+ and Y3+ ions in human plasma has been studied by computer simulation using the program HySS2009. A literature computer model of blood plasma was updated and comprised 9 metals, 43 ligands and over 6100 complexes. To this model critically evaluated data of Al3+, Gd3+ and Y3+ constants with blood plasma ligands have been added. Low molecular mass (LMM) speciation of Al3+ ion strongly depends upon the chosen equilibrium model of the metal - phosphate and metal - citrate systems. The obtained computer simulation of LMM speciation data of Al3+ ion were: AlPO(4)Cit (40.7%), AlPO(4)CitOH (22.9%), AlCitOH (19.2%) and AlPO4(OH) (12.7%) (% of total LMM Al species pool); for Gd3+ ion: GdAspCit (30%) and GdCit(OH)(2) (20%) (% of total [Gd]) and for Y3+ ion: YCit (48%), Y(CO3)(2) (32%) and Y(CO3) (11%) (% of total [Y]). Citrate appears as the important binding and mobilizing ligand for all examined ions, while the dominating species are the ternary ones.",
journal = "Acta Chimica Slovenica",
title = "Computer Simulation of Speciation of Trivalent Aluminum, Gadolinium and Yttrium Ions in Human Blood Plasma",
volume = "60",
number = "4",
pages = "861-869",
url = "https://hdl.handle.net/21.15107/rcub_vinar_5824"
}

Jakovljević, I., Petrović, Đ., Joksović, L. G., Lazarević, I.,& Durdevic, P.. (2013). Computer Simulation of Speciation of Trivalent Aluminum, Gadolinium and Yttrium Ions in Human Blood Plasma. in Acta Chimica Slovenica, 60(4), 861-869.
https://hdl.handle.net/21.15107/rcub_vinar_5824

Jakovljević I, Petrović Đ, Joksović LG, Lazarević I, Durdevic P. Computer Simulation of Speciation of Trivalent Aluminum, Gadolinium and Yttrium Ions in Human Blood Plasma. in Acta Chimica Slovenica. 2013;60(4):861-869.
https://hdl.handle.net/21.15107/rcub_vinar_5824 .

Jakovljević, Ivan, Petrović, Đorđe, Joksović, Ljubinka G., Lazarević, Ivan, Durdevic, Predrag, "Computer Simulation of Speciation of Trivalent Aluminum, Gadolinium and Yttrium Ions in Human Blood Plasma" in Acta Chimica Slovenica, 60, no. 4 (2013):861-869,
https://hdl.handle.net/21.15107/rcub_vinar_5824 .

TY  - JOUR
AU  - Leovac, Vukadin M.
AU  - Bogdanović, Goran A.
AU  - Jovanović, Ljiljana S.
AU  - Joksović, Ljubinka G.
AU  - Marković, Violeta
AU  - Joksović, Milan D.
AU  - Misirlić-Denčić, Sonja
AU  - Isaković, Anđelka
AU  - Markovic, Ivanka
AU  - Heinemann, Frank W.
AU  - Trifunović, Srećko R.
AU  - Dalovic, Ivica
PY  - 2011
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/4592
AB  - New polymeric copper(II) complexes with two tridentate ONS thiosemicarbazone ligands containing substituted pyrazolone moiety were synthesized and characterized by means of spectroscopic, electrochemical and crystallographic techniques. While both ligands exist as different tautomers in the solid state and DMSO-d(6) solution, Cu(II) ion coordinates the ligands from the same tautomeric form with square-pyramidal geometry around each Cu atom. In the crystal structures, the copper(II) complex cation forms polymeric chains {[Cu(L)Cl(+)]}(n) with a bridging chlorine atom. One of the complexes was found to have a significantly higher cytotoxic potential in comparison with cisplatin in inhibition of several cell lines (HL60, REH, C6, L929 and B16). The results obtained on the basis of flow cytometry indicated that apoptosis could be possible mechanism of cell death. (C) 2011 Elsevier Inc. All rights reserved.
T2  - Journal of Inorganic Biochemistry
T1  - Synthesis, characterization and antitumor activity of polymeric copper(II) complexes with thiosemicarbazones of 3-methyl-5-oxo-1-phenyl-3-pyrazolin-4-carboxaldehyde and 5-oxo-3-phenyl-3-pyrazolin-4-carboxaldehyde
VL  - 105
IS  - 11
SP  - 1413
EP  - 1421
DO  - 10.1016/j.jinorgbio.2011.07.021
ER  - 

@article{
author = "Leovac, Vukadin M. and Bogdanović, Goran A. and Jovanović, Ljiljana S. and Joksović, Ljubinka G. and Marković, Violeta and Joksović, Milan D. and Misirlić-Denčić, Sonja and Isaković, Anđelka and Markovic, Ivanka and Heinemann, Frank W. and Trifunović, Srećko R. and Dalovic, Ivica",
year = "2011",
abstract = "New polymeric copper(II) complexes with two tridentate ONS thiosemicarbazone ligands containing substituted pyrazolone moiety were synthesized and characterized by means of spectroscopic, electrochemical and crystallographic techniques. While both ligands exist as different tautomers in the solid state and DMSO-d(6) solution, Cu(II) ion coordinates the ligands from the same tautomeric form with square-pyramidal geometry around each Cu atom. In the crystal structures, the copper(II) complex cation forms polymeric chains {[Cu(L)Cl(+)]}(n) with a bridging chlorine atom. One of the complexes was found to have a significantly higher cytotoxic potential in comparison with cisplatin in inhibition of several cell lines (HL60, REH, C6, L929 and B16). The results obtained on the basis of flow cytometry indicated that apoptosis could be possible mechanism of cell death. (C) 2011 Elsevier Inc. All rights reserved.",
journal = "Journal of Inorganic Biochemistry",
title = "Synthesis, characterization and antitumor activity of polymeric copper(II) complexes with thiosemicarbazones of 3-methyl-5-oxo-1-phenyl-3-pyrazolin-4-carboxaldehyde and 5-oxo-3-phenyl-3-pyrazolin-4-carboxaldehyde",
volume = "105",
number = "11",
pages = "1413-1421",
doi = "10.1016/j.jinorgbio.2011.07.021"
}

Leovac, V. M., Bogdanović, G. A., Jovanović, L. S., Joksović, L. G., Marković, V., Joksović, M. D., Misirlić-Denčić, S., Isaković, A., Markovic, I., Heinemann, F. W., Trifunović, S. R.,& Dalovic, I.. (2011). Synthesis, characterization and antitumor activity of polymeric copper(II) complexes with thiosemicarbazones of 3-methyl-5-oxo-1-phenyl-3-pyrazolin-4-carboxaldehyde and 5-oxo-3-phenyl-3-pyrazolin-4-carboxaldehyde. in Journal of Inorganic Biochemistry, 105(11), 1413-1421.
https://doi.org/10.1016/j.jinorgbio.2011.07.021

Leovac VM, Bogdanović GA, Jovanović LS, Joksović LG, Marković V, Joksović MD, Misirlić-Denčić S, Isaković A, Markovic I, Heinemann FW, Trifunović SR, Dalovic I. Synthesis, characterization and antitumor activity of polymeric copper(II) complexes with thiosemicarbazones of 3-methyl-5-oxo-1-phenyl-3-pyrazolin-4-carboxaldehyde and 5-oxo-3-phenyl-3-pyrazolin-4-carboxaldehyde. in Journal of Inorganic Biochemistry. 2011;105(11):1413-1421.
doi:10.1016/j.jinorgbio.2011.07.021 .

Leovac, Vukadin M., Bogdanović, Goran A., Jovanović, Ljiljana S., Joksović, Ljubinka G., Marković, Violeta, Joksović, Milan D., Misirlić-Denčić, Sonja, Isaković, Anđelka, Markovic, Ivanka, Heinemann, Frank W., Trifunović, Srećko R., Dalovic, Ivica, "Synthesis, characterization and antitumor activity of polymeric copper(II) complexes with thiosemicarbazones of 3-methyl-5-oxo-1-phenyl-3-pyrazolin-4-carboxaldehyde and 5-oxo-3-phenyl-3-pyrazolin-4-carboxaldehyde" in Journal of Inorganic Biochemistry, 105, no. 11 (2011):1413-1421,
https://doi.org/10.1016/j.jinorgbio.2011.07.021 . .