TY  - JOUR
AU  - Srđenović, Branislava U.
AU  - Slavic, Marija N.
AU  - Stankov, Karmen M.
AU  - Kladar, Nebojsa V.
AU  - Jović, Danica S.
AU  - Seke, Mariana
AU  - Bogdanović, Višnja V.
PY  - 2015
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/767
AB  - Fullerenol (C-60(OH)(24)) nanoparticles (FNP) have a significant role in biomedical research due to their numerous biological activities, some of which have cytoprotective and anti-oxidative properties. The aim of this study was to measure distribution of fullerenol nanoparticles and zeta potential in cell medium RPMI 1640 with 10% fetal bovine serum (FBS) and to investigate the influence of FNP on Chinese hamster ovary cells (CHO-K1) survival, as well as to determine the activity of three antioxidative enzymes: superoxide-dismutase, glutathione-reductase and glutathione-S-transferase in mitomycin C-treated cell line. Our investigation implies that FNP, as a strong antioxidant, influences the cellular redox state and enzyme activities and thus may reduce cell proliferation, which confirms that FNP could be exploited for its use as a cytoprotective agent.
T2  - Hemijska industrija
T1  - Size distribution of fullerenol nanoparticles in cell culture medium and their influence on antioxidative enzymes in Chinese hamster ovary cells
VL  - 69
IS  - 4
SP  - 425
EP  - 431
DO  - 10.2298/HEMIND131218054S
ER  - 

@article{
author = "Srđenović, Branislava U. and Slavic, Marija N. and Stankov, Karmen M. and Kladar, Nebojsa V. and Jović, Danica S. and Seke, Mariana and Bogdanović, Višnja V.",
year = "2015",
abstract = "Fullerenol (C-60(OH)(24)) nanoparticles (FNP) have a significant role in biomedical research due to their numerous biological activities, some of which have cytoprotective and anti-oxidative properties. The aim of this study was to measure distribution of fullerenol nanoparticles and zeta potential in cell medium RPMI 1640 with 10% fetal bovine serum (FBS) and to investigate the influence of FNP on Chinese hamster ovary cells (CHO-K1) survival, as well as to determine the activity of three antioxidative enzymes: superoxide-dismutase, glutathione-reductase and glutathione-S-transferase in mitomycin C-treated cell line. Our investigation implies that FNP, as a strong antioxidant, influences the cellular redox state and enzyme activities and thus may reduce cell proliferation, which confirms that FNP could be exploited for its use as a cytoprotective agent.",
journal = "Hemijska industrija",
title = "Size distribution of fullerenol nanoparticles in cell culture medium and their influence on antioxidative enzymes in Chinese hamster ovary cells",
volume = "69",
number = "4",
pages = "425-431",
doi = "10.2298/HEMIND131218054S"
}

Srđenović, B. U., Slavic, M. N., Stankov, K. M., Kladar, N. V., Jović, D. S., Seke, M.,& Bogdanović, V. V.. (2015). Size distribution of fullerenol nanoparticles in cell culture medium and their influence on antioxidative enzymes in Chinese hamster ovary cells. in Hemijska industrija, 69(4), 425-431.
https://doi.org/10.2298/HEMIND131218054S

Srđenović BU, Slavic MN, Stankov KM, Kladar NV, Jović DS, Seke M, Bogdanović VV. Size distribution of fullerenol nanoparticles in cell culture medium and their influence on antioxidative enzymes in Chinese hamster ovary cells. in Hemijska industrija. 2015;69(4):425-431.
doi:10.2298/HEMIND131218054S .

Srđenović, Branislava U., Slavic, Marija N., Stankov, Karmen M., Kladar, Nebojsa V., Jović, Danica S., Seke, Mariana, Bogdanović, Višnja V., "Size distribution of fullerenol nanoparticles in cell culture medium and their influence on antioxidative enzymes in Chinese hamster ovary cells" in Hemijska industrija, 69, no. 4 (2015):425-431,
https://doi.org/10.2298/HEMIND131218054S . .

TY  - JOUR
AU  - Mrđanović, Jasminka Ž.
AU  - Solajic, Slavica V.
AU  - Bogdanović, Višnja V.
AU  - Đorđević, Aleksandar N.
AU  - Bogdanović, Gordana M.
AU  - Injac, Rade D.
AU  - Rakočević, Zlatko Lj.
PY  - 2012
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/4935
AB  - Fullerenol C-60(OH)(24) nano particles (FNP) show various biological activities in different experimental models. We evaluated genotoxic and antigenotoxic effects of FNP on human peripheral blood lymphocytes (PBL) using two cytogenetic assays. The effects of FNP were evaluated on the frequency of chromosomal aberrations (CA) and micronuclei (MN) on undamaged and mitomycin C (MMC)-damaged PBL. FNP number distribution in a culture medium with serum showed that predominant particles were about 180 nm and 90 nm respectively. Cytogenetic assays showed that FNP decreased chromosomal aberrations and micronucleus frequency on the undamaged and the MMC- damaged human PBL at concentration range from 5.54 mu M to 221.60 mu M. Our research confirmed that FNP did not exhibit genotoxic but induced antigenotoxic effects at subcytotoxic concentrations on human lymphocytes.
T2  - Digest Journal of Nanomaterials and Biostructures
T1  - Effects of Fullerenol Nano Particles C-60(Oh)(24) on Micronuclei and Chromosomal Aberrations Frequency in Peripheral Blood Lymphocytes
VL  - 7
IS  - 2
SP  - 673
EP  - 686
UR  - https://hdl.handle.net/21.15107/rcub_vinar_4935
ER  - 

@article{
author = "Mrđanović, Jasminka Ž. and Solajic, Slavica V. and Bogdanović, Višnja V. and Đorđević, Aleksandar N. and Bogdanović, Gordana M. and Injac, Rade D. and Rakočević, Zlatko Lj.",
year = "2012",
abstract = "Fullerenol C-60(OH)(24) nano particles (FNP) show various biological activities in different experimental models. We evaluated genotoxic and antigenotoxic effects of FNP on human peripheral blood lymphocytes (PBL) using two cytogenetic assays. The effects of FNP were evaluated on the frequency of chromosomal aberrations (CA) and micronuclei (MN) on undamaged and mitomycin C (MMC)-damaged PBL. FNP number distribution in a culture medium with serum showed that predominant particles were about 180 nm and 90 nm respectively. Cytogenetic assays showed that FNP decreased chromosomal aberrations and micronucleus frequency on the undamaged and the MMC- damaged human PBL at concentration range from 5.54 mu M to 221.60 mu M. Our research confirmed that FNP did not exhibit genotoxic but induced antigenotoxic effects at subcytotoxic concentrations on human lymphocytes.",
journal = "Digest Journal of Nanomaterials and Biostructures",
title = "Effects of Fullerenol Nano Particles C-60(Oh)(24) on Micronuclei and Chromosomal Aberrations Frequency in Peripheral Blood Lymphocytes",
volume = "7",
number = "2",
pages = "673-686",
url = "https://hdl.handle.net/21.15107/rcub_vinar_4935"
}

Mrđanović, J. Ž., Solajic, S. V., Bogdanović, V. V., Đorđević, A. N., Bogdanović, G. M., Injac, R. D.,& Rakočević, Z. Lj.. (2012). Effects of Fullerenol Nano Particles C-60(Oh)(24) on Micronuclei and Chromosomal Aberrations Frequency in Peripheral Blood Lymphocytes. in Digest Journal of Nanomaterials and Biostructures, 7(2), 673-686.
https://hdl.handle.net/21.15107/rcub_vinar_4935

Mrđanović JŽ, Solajic SV, Bogdanović VV, Đorđević AN, Bogdanović GM, Injac RD, Rakočević ZL. Effects of Fullerenol Nano Particles C-60(Oh)(24) on Micronuclei and Chromosomal Aberrations Frequency in Peripheral Blood Lymphocytes. in Digest Journal of Nanomaterials and Biostructures. 2012;7(2):673-686.
https://hdl.handle.net/21.15107/rcub_vinar_4935 .

Mrđanović, Jasminka Ž., Solajic, Slavica V., Bogdanović, Višnja V., Đorđević, Aleksandar N., Bogdanović, Gordana M., Injac, Rade D., Rakočević, Zlatko Lj., "Effects of Fullerenol Nano Particles C-60(Oh)(24) on Micronuclei and Chromosomal Aberrations Frequency in Peripheral Blood Lymphocytes" in Digest Journal of Nanomaterials and Biostructures, 7, no. 2 (2012):673-686,
https://hdl.handle.net/21.15107/rcub_vinar_4935 .