TY  - JOUR
AU  - Stojadinović, Milica
AU  - Mašulović, Dragan
AU  - Kadija, Marko
AU  - Milovanović, Darko
AU  - Milić, Nataša
AU  - Marković, Ksenija
AU  - Ciraj-Bjelac, Olivera
PY  - 2024
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/12721
AB  - Background and Objectives: Total knee arthroplasty (TKA) has become the treatment of choice for advanced osteoarthritis. The aim of this paper was to show the possibilities of optimizing the Perth CT protocol, which is highly effective for preoperative planning and postoperative assessment of alignment. Materials and Methods: The cross-sectional study comprised 16 patients for preoperative planning or postoperative evaluation of TKA. All patients were examined with the standard and optimized Perth CT protocol using advance techniques, including automatic exposure control (AEC), iterative image reconstruction (IR), as well as a single-energy projection-based metal artifact reduction algorithm for eliminating prosthesis artifacts. The effective radiation dose (E) was determined based on the dose report. Imaging quality is determined according to subjective and objective (values of signal to noise ratio (SdNR) and figure of merit (FOM)) criteria. Results: The effective radiation dose with the optimized protocol was significantly lower compared to the standard protocol (p < 0.001), while in patients with the knee prosthesis, E increased significantly less with the optimized protocol compared to the standard protocol. No significant difference was observed in the subjective evaluation of image quality between protocols (p > 0.05). Analyzing the objective criteria for image quality optimized protocols resulted in lower SdNR values and higher FOM values. No significant difference of image quality was determined using the SdNR and FOM as per the specified protocols and parts of extremities, and for the presence of prothesis. Conclusions: Retrospecting the ALARA (‘As Low As Reasonably Achievable’) principles, it is possible to optimize the Perth CT protocol by reducing the kV and mAs values and by changing the collimation and increasing the pitch factor. Advanced IR techniques were used in both protocols, and AEC was used in the optimized protocol. The effective dose of radiation can be reduced five times, and the image quality will be satisfactory.
T2  - Medicina
T1  - Optimization of the “Perth CT” Protocol for Preoperative Planning and Postoperative Evaluation in Total Knee Arthroplasty
VL  - 60
IS  - 1
SP  - 98
DO  - 10.3390/medicina60010098
ER  - 

@article{
author = "Stojadinović, Milica and Mašulović, Dragan and Kadija, Marko and Milovanović, Darko and Milić, Nataša and Marković, Ksenija and Ciraj-Bjelac, Olivera",
year = "2024",
abstract = "Background and Objectives: Total knee arthroplasty (TKA) has become the treatment of choice for advanced osteoarthritis. The aim of this paper was to show the possibilities of optimizing the Perth CT protocol, which is highly effective for preoperative planning and postoperative assessment of alignment. Materials and Methods: The cross-sectional study comprised 16 patients for preoperative planning or postoperative evaluation of TKA. All patients were examined with the standard and optimized Perth CT protocol using advance techniques, including automatic exposure control (AEC), iterative image reconstruction (IR), as well as a single-energy projection-based metal artifact reduction algorithm for eliminating prosthesis artifacts. The effective radiation dose (E) was determined based on the dose report. Imaging quality is determined according to subjective and objective (values of signal to noise ratio (SdNR) and figure of merit (FOM)) criteria. Results: The effective radiation dose with the optimized protocol was significantly lower compared to the standard protocol (p < 0.001), while in patients with the knee prosthesis, E increased significantly less with the optimized protocol compared to the standard protocol. No significant difference was observed in the subjective evaluation of image quality between protocols (p > 0.05). Analyzing the objective criteria for image quality optimized protocols resulted in lower SdNR values and higher FOM values. No significant difference of image quality was determined using the SdNR and FOM as per the specified protocols and parts of extremities, and for the presence of prothesis. Conclusions: Retrospecting the ALARA (‘As Low As Reasonably Achievable’) principles, it is possible to optimize the Perth CT protocol by reducing the kV and mAs values and by changing the collimation and increasing the pitch factor. Advanced IR techniques were used in both protocols, and AEC was used in the optimized protocol. The effective dose of radiation can be reduced five times, and the image quality will be satisfactory.",
journal = "Medicina",
title = "Optimization of the “Perth CT” Protocol for Preoperative Planning and Postoperative Evaluation in Total Knee Arthroplasty",
volume = "60",
number = "1",
pages = "98",
doi = "10.3390/medicina60010098"
}

Stojadinović, M., Mašulović, D., Kadija, M., Milovanović, D., Milić, N., Marković, K.,& Ciraj-Bjelac, O.. (2024). Optimization of the “Perth CT” Protocol for Preoperative Planning and Postoperative Evaluation in Total Knee Arthroplasty. in Medicina, 60(1), 98.
https://doi.org/10.3390/medicina60010098

Stojadinović M, Mašulović D, Kadija M, Milovanović D, Milić N, Marković K, Ciraj-Bjelac O. Optimization of the “Perth CT” Protocol for Preoperative Planning and Postoperative Evaluation in Total Knee Arthroplasty. in Medicina. 2024;60(1):98.
doi:10.3390/medicina60010098 .

Stojadinović, Milica, Mašulović, Dragan, Kadija, Marko, Milovanović, Darko, Milić, Nataša, Marković, Ksenija, Ciraj-Bjelac, Olivera, "Optimization of the “Perth CT” Protocol for Preoperative Planning and Postoperative Evaluation in Total Knee Arthroplasty" in Medicina, 60, no. 1 (2024):98,
https://doi.org/10.3390/medicina60010098 . .

TY  - JOUR
AU  - Milin-Lazović, Jelena
AU  - Madžarević, Petar
AU  - Rajović, Nina
AU  - Đorđević, Vladimir
AU  - Milić, Nikola
AU  - Pavlović, Sonja
AU  - Veljković, Nevena V.
AU  - Milić, Nataša M.
AU  - Radenković, Dejan
PY  - 2021
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/9861
AB  - Introduction: The analysis of cell-free DNA (cfDNA) for genetic abnormalities is a promising new approach for the diagnosis and prognosis of pancreatic cancer patients. Insights into the molecular characteristics of pancreatic cancer may provide valuable information, leading to its earlier detection and the development of targeted therapies. Material and Methods: We conducted a systematic review and a meta-analysis of studies that reported cfDNA in pancreatic ductal adenocarcinoma (PDAC). The studies were considered eligible if they included patients with PDAC, if they had blood tests for cfDNA/ctDNA, and if they analyzed the prognostic value of cfDNA/ctDNA for patients’ survival. The studies published before 22 October 2020 were identified through the PubMED, EMBASE, Web of Science and Cochrane Library databases. The assessed outcomes were the overall (OS) and progression-free survival (PFS), expressed as the log hazard ratio (HR) and standard error (SE). The summary of the HR effect size was estimated by pooling the individual trial results using the Review Manager, version 5.3, Cochrane Collaboration. The heterogeneity was assessed using the Cochran Q test and I2 statistic. Results: In total, 48 studies were included in the qualitative review, while 44 were assessed in the quantitative synthesis, with the total number of patients included being 3524. Overall negative impacts of cfDNA and KRAS mutations on OS and PFS in PDAC (HR = 2.42, 95% CI: 1.95–2.99 and HR = 2.46, 95% CI: 2.01–3.00, respectively) were found. The subgroup analysis of the locally advanced and metastatic disease presented similar results (HR = 2.51, 95% CI: 1.90–3.31). In the studies assessing the pre-treatment presence of KRAS, there was a moderate to high degree of heterogeneity (I2 = 87% and I2 = 48%, for OS and PFS, respectively), which was remarkably decreased in the analysis of the studies measuring post-treatment KRAS (I2 = 24% and I2 = 0%, for OS and PFS, respectively). The patients who were KRAS positive before but KRAS negative after treatment had a better prognosis than the persistently KRAS-positive patients (HR = 5.30, 95% CI: 1.02–27.63). Conclusion: The assessment of KRAS mutation by liquid biopsy can be considered as an additional tool for the estimation of the disease course and outcome in PDAC patients.
T2  - Cancers
T1  - Meta-analysis of circulating cell-free dna’s role in the prognosis of pancreatic cancer
VL  - 13
IS  - 14
SP  - 3378
DO  - 10.3390/cancers13143378
ER  - 

@article{
author = "Milin-Lazović, Jelena and Madžarević, Petar and Rajović, Nina and Đorđević, Vladimir and Milić, Nikola and Pavlović, Sonja and Veljković, Nevena V. and Milić, Nataša M. and Radenković, Dejan",
year = "2021",
abstract = "Introduction: The analysis of cell-free DNA (cfDNA) for genetic abnormalities is a promising new approach for the diagnosis and prognosis of pancreatic cancer patients. Insights into the molecular characteristics of pancreatic cancer may provide valuable information, leading to its earlier detection and the development of targeted therapies. Material and Methods: We conducted a systematic review and a meta-analysis of studies that reported cfDNA in pancreatic ductal adenocarcinoma (PDAC). The studies were considered eligible if they included patients with PDAC, if they had blood tests for cfDNA/ctDNA, and if they analyzed the prognostic value of cfDNA/ctDNA for patients’ survival. The studies published before 22 October 2020 were identified through the PubMED, EMBASE, Web of Science and Cochrane Library databases. The assessed outcomes were the overall (OS) and progression-free survival (PFS), expressed as the log hazard ratio (HR) and standard error (SE). The summary of the HR effect size was estimated by pooling the individual trial results using the Review Manager, version 5.3, Cochrane Collaboration. The heterogeneity was assessed using the Cochran Q test and I2 statistic. Results: In total, 48 studies were included in the qualitative review, while 44 were assessed in the quantitative synthesis, with the total number of patients included being 3524. Overall negative impacts of cfDNA and KRAS mutations on OS and PFS in PDAC (HR = 2.42, 95% CI: 1.95–2.99 and HR = 2.46, 95% CI: 2.01–3.00, respectively) were found. The subgroup analysis of the locally advanced and metastatic disease presented similar results (HR = 2.51, 95% CI: 1.90–3.31). In the studies assessing the pre-treatment presence of KRAS, there was a moderate to high degree of heterogeneity (I2 = 87% and I2 = 48%, for OS and PFS, respectively), which was remarkably decreased in the analysis of the studies measuring post-treatment KRAS (I2 = 24% and I2 = 0%, for OS and PFS, respectively). The patients who were KRAS positive before but KRAS negative after treatment had a better prognosis than the persistently KRAS-positive patients (HR = 5.30, 95% CI: 1.02–27.63). Conclusion: The assessment of KRAS mutation by liquid biopsy can be considered as an additional tool for the estimation of the disease course and outcome in PDAC patients.",
journal = "Cancers",
title = "Meta-analysis of circulating cell-free dna’s role in the prognosis of pancreatic cancer",
volume = "13",
number = "14",
pages = "3378",
doi = "10.3390/cancers13143378"
}

Milin-Lazović, J., Madžarević, P., Rajović, N., Đorđević, V., Milić, N., Pavlović, S., Veljković, N. V., Milić, N. M.,& Radenković, D.. (2021). Meta-analysis of circulating cell-free dna’s role in the prognosis of pancreatic cancer. in Cancers, 13(14), 3378.
https://doi.org/10.3390/cancers13143378

Milin-Lazović J, Madžarević P, Rajović N, Đorđević V, Milić N, Pavlović S, Veljković NV, Milić NM, Radenković D. Meta-analysis of circulating cell-free dna’s role in the prognosis of pancreatic cancer. in Cancers. 2021;13(14):3378.
doi:10.3390/cancers13143378 .

Milin-Lazović, Jelena, Madžarević, Petar, Rajović, Nina, Đorđević, Vladimir, Milić, Nikola, Pavlović, Sonja, Veljković, Nevena V., Milić, Nataša M., Radenković, Dejan, "Meta-analysis of circulating cell-free dna’s role in the prognosis of pancreatic cancer" in Cancers, 13, no. 14 (2021):3378,
https://doi.org/10.3390/cancers13143378 . .