TY  - JOUR
AU  - Đurić, Tamara
AU  - Živković, Maja
AU  - Milosevic, Biljana
AU  - Anđelevski, Magdalena
AU  - Cvetković, Mirjana
AU  - Kostić, Mirjana M.
AU  - Stanković, Aleksandra
PY  - 2014
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/5950
AB  - Congenital anomalies of the kidney and urinary tract (CAKUT) are a common cause of progressive chronic kidney disease that may lead to end-stage renal disease and renal replacement therapy in childhood. Altered expression or activity of matrix metalloproteinases (MMPs) have been found in CAKUT. The MMP-1, -3, and -8 polymorphisms studied here are located in the gene promoters and alter expression. Our aim was to investigate associations of MMP polymorphisms, solely and in haplotypes, with CAKUT in children. A case-control study with 101 pediatric patients and 281 controls was performed. The MMP-1 (-1607 1G/2G), -3 (5A/6A), and -8 (-799 C/T) genotypes were determined by PCR-restriction fragment length polymorphism. We found statistically significant associations of MMP-3 5A/6A polymorphism (p LT 0.0001) and 1G(-1607)-6A haplotype, with no preferences for MMP-8 -799C or T alleles, with CAKUT (OR = 2.93, 95 % CI 1.43-5.98, adjusted for gender, p = 0.003) and with obstructive uropathies in a subgroup of patients (OR = 4.57, 95 % CI 2.74-7.61, adjusted for gender, p LT 0.0001). MMP-3 genotypes and MMP-3 and -1 haplotypes encompassing either MMP-8 -799C or T alleles were associated with CAKUT and obstructive uropathies in pediatric patients. Still, functional and association studies are needed to elucidate evident roles of MMPs in CAKUT.
T2  - Pediatric Nephrology
T1  - MMP-1 and-3 haplotype is associated with congenital anomalies of the kidney and urinary tract
VL  - 29
IS  - 5
SP  - 879
EP  - 884
DO  - 10.1007/s00467-013-2699-x
ER  - 

@article{
author = "Đurić, Tamara and Živković, Maja and Milosevic, Biljana and Anđelevski, Magdalena and Cvetković, Mirjana and Kostić, Mirjana M. and Stanković, Aleksandra",
year = "2014",
abstract = "Congenital anomalies of the kidney and urinary tract (CAKUT) are a common cause of progressive chronic kidney disease that may lead to end-stage renal disease and renal replacement therapy in childhood. Altered expression or activity of matrix metalloproteinases (MMPs) have been found in CAKUT. The MMP-1, -3, and -8 polymorphisms studied here are located in the gene promoters and alter expression. Our aim was to investigate associations of MMP polymorphisms, solely and in haplotypes, with CAKUT in children. A case-control study with 101 pediatric patients and 281 controls was performed. The MMP-1 (-1607 1G/2G), -3 (5A/6A), and -8 (-799 C/T) genotypes were determined by PCR-restriction fragment length polymorphism. We found statistically significant associations of MMP-3 5A/6A polymorphism (p LT 0.0001) and 1G(-1607)-6A haplotype, with no preferences for MMP-8 -799C or T alleles, with CAKUT (OR = 2.93, 95 % CI 1.43-5.98, adjusted for gender, p = 0.003) and with obstructive uropathies in a subgroup of patients (OR = 4.57, 95 % CI 2.74-7.61, adjusted for gender, p LT 0.0001). MMP-3 genotypes and MMP-3 and -1 haplotypes encompassing either MMP-8 -799C or T alleles were associated with CAKUT and obstructive uropathies in pediatric patients. Still, functional and association studies are needed to elucidate evident roles of MMPs in CAKUT.",
journal = "Pediatric Nephrology",
title = "MMP-1 and-3 haplotype is associated with congenital anomalies of the kidney and urinary tract",
volume = "29",
number = "5",
pages = "879-884",
doi = "10.1007/s00467-013-2699-x"
}

Đurić, T., Živković, M., Milosevic, B., Anđelevski, M., Cvetković, M., Kostić, M. M.,& Stanković, A.. (2014). MMP-1 and-3 haplotype is associated with congenital anomalies of the kidney and urinary tract. in Pediatric Nephrology, 29(5), 879-884.
https://doi.org/10.1007/s00467-013-2699-x

Đurić T, Živković M, Milosevic B, Anđelevski M, Cvetković M, Kostić MM, Stanković A. MMP-1 and-3 haplotype is associated with congenital anomalies of the kidney and urinary tract. in Pediatric Nephrology. 2014;29(5):879-884.
doi:10.1007/s00467-013-2699-x .

Đurić, Tamara, Živković, Maja, Milosevic, Biljana, Anđelevski, Magdalena, Cvetković, Mirjana, Kostić, Mirjana M., Stanković, Aleksandra, "MMP-1 and-3 haplotype is associated with congenital anomalies of the kidney and urinary tract" in Pediatric Nephrology, 29, no. 5 (2014):879-884,
https://doi.org/10.1007/s00467-013-2699-x . .

TY  - JOUR
AU  - Đurić, Tamara
AU  - Đorđević, Ana
AU  - Lukić, Nikola
AU  - Anđelevski, Magdalena
AU  - Živković, Maja
AU  - Stanković, Aleksandra
PY  - 2013
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/5188
AB  - Nitric oxide inhibits adhesion of thrombocytes, proliferation and migration of smooth muscle cells and restricts oxidation of atherogenic low-density lipoproteins. Therefore, decreased production or activity of NO may play a role in the initiation, progression or complications of atherosclerosis. The aim of this study was to estimate the effect of Glu298Asp eNOS gene polymorphism on the individual risk for development of complicated carotid atherosclerotic plaque in patients from Serbia with advanced carotid atherosclerosis (CA) who had undergone endarterectomy. The study population included 233 patients. eNOS G894T gene polymorphism was identified by PCR and RFLP methods. Multivariate logistic regression analysis showed that Asp298Asp is an independent risk factor for the presence of complicated plaques in CA patients. Patients who were homozygous for the Asp298 allele had an adjusted OR of 4.36 for the development of complicated plaques compared to those that carry the Glu298 allele. Further validation and replication studies are needed.
T2  - Archives of Biological Sciences
T1  - ENOS Glu298Asp Polymorphism Is Associated with Development of Complicated Plaques in Patients from Serbia with Advanced Carotid Atherosclerosis
VL  - 65
IS  - 1
SP  - 143
EP  - 149
DO  - 10.2298/ABS1301143D
ER  - 

@article{
author = "Đurić, Tamara and Đorđević, Ana and Lukić, Nikola and Anđelevski, Magdalena and Živković, Maja and Stanković, Aleksandra",
year = "2013",
abstract = "Nitric oxide inhibits adhesion of thrombocytes, proliferation and migration of smooth muscle cells and restricts oxidation of atherogenic low-density lipoproteins. Therefore, decreased production or activity of NO may play a role in the initiation, progression or complications of atherosclerosis. The aim of this study was to estimate the effect of Glu298Asp eNOS gene polymorphism on the individual risk for development of complicated carotid atherosclerotic plaque in patients from Serbia with advanced carotid atherosclerosis (CA) who had undergone endarterectomy. The study population included 233 patients. eNOS G894T gene polymorphism was identified by PCR and RFLP methods. Multivariate logistic regression analysis showed that Asp298Asp is an independent risk factor for the presence of complicated plaques in CA patients. Patients who were homozygous for the Asp298 allele had an adjusted OR of 4.36 for the development of complicated plaques compared to those that carry the Glu298 allele. Further validation and replication studies are needed.",
journal = "Archives of Biological Sciences",
title = "ENOS Glu298Asp Polymorphism Is Associated with Development of Complicated Plaques in Patients from Serbia with Advanced Carotid Atherosclerosis",
volume = "65",
number = "1",
pages = "143-149",
doi = "10.2298/ABS1301143D"
}

Đurić, T., Đorđević, A., Lukić, N., Anđelevski, M., Živković, M.,& Stanković, A.. (2013). ENOS Glu298Asp Polymorphism Is Associated with Development of Complicated Plaques in Patients from Serbia with Advanced Carotid Atherosclerosis. in Archives of Biological Sciences, 65(1), 143-149.
https://doi.org/10.2298/ABS1301143D

Đurić T, Đorđević A, Lukić N, Anđelevski M, Živković M, Stanković A. ENOS Glu298Asp Polymorphism Is Associated with Development of Complicated Plaques in Patients from Serbia with Advanced Carotid Atherosclerosis. in Archives of Biological Sciences. 2013;65(1):143-149.
doi:10.2298/ABS1301143D .

Đurić, Tamara, Đorđević, Ana, Lukić, Nikola, Anđelevski, Magdalena, Živković, Maja, Stanković, Aleksandra, "ENOS Glu298Asp Polymorphism Is Associated with Development of Complicated Plaques in Patients from Serbia with Advanced Carotid Atherosclerosis" in Archives of Biological Sciences, 65, no. 1 (2013):143-149,
https://doi.org/10.2298/ABS1301143D . .