TY  - CONF
AU  - Jovanović, Irena
AU  - Nedeljković, Milica
AU  - Medić-Milijić, Nataša
AU  - Spurnić, Igor
AU  - Milovanović, Zorka
AU  - Tomić, Tijana
AU  - Tanić, Nasta
AU  - Tanić, Nikola
PY  - 2023
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/12633
AB  - Background: Breast cancer is the most commonly occurring malignancy and the leading cause of cancer-related death in women. Triple-negaƟ ve breast cancer (TNBC) is the most aggressive breast cancer subtype and is associated with high recurrence rates, high incidence of distant metastases and poor overall survival. The aim of this study was to invesƟ gate the role of cludin 3, claudin 4 and claudin 7 in TNBC promoƟ on and progression. Claudins are Ɵ ght juncƟ on (TJ) integral membrane proteins that are key regulators of the paracellular pathway. Materials and methods: This is a retrospecƟ ve analysis of 125 paƟ ents with triple-negaƟ ve breast cancer operated at the InsƟ tute of Oncology and Radiology of Serbia in the period from 2009 to 2014. The expression of claudin 3, 4 and 7 was observed using the immunohistochemical staining method. The Allred scoring system was used with cut-off values: ≤4 and >4 (low/ high expression). Results: Our results showed that the expression of claudins 3 and 4 correlate with higher nuclear gradus and low desease free interval (DFI). More over, the expression of claudin 3 and claudin 4 correlates (Spearman test p˂0.0001). In addiƟ on, high expression of claudin 7 is signifi cantly related to low DFI of paƟ ents (p˂0.005) and distant metastases. Conclusions: We concluded that claudin 3, claudin 4 and claudin 7 have signifi cant impact on TNBC progression. Namely, elevated expression of these proteins signifi cantly correlates with low DFI and distant metastases. In other words, elevated expression of claudins is a bad news for TNBC paƟ ents. Therefore, the expression of claudins could be a good prognosƟ c marker for TNBC paƟ ents and potential target for future therapy protocols.
PB  - Belgrade : Serbian Association for Cancer Research
C3  - Oncology Insights
T1  - Role of claudins 3,4 and 7 in triple negative breast cancer progression
IS  - 1
SP  - 63
EP  - 63
UR  - https://hdl.handle.net/21.15107/rcub_vinar_12633
ER  - 

@conference{
author = "Jovanović, Irena and Nedeljković, Milica and Medić-Milijić, Nataša and Spurnić, Igor and Milovanović, Zorka and Tomić, Tijana and Tanić, Nasta and Tanić, Nikola",
year = "2023",
abstract = "Background: Breast cancer is the most commonly occurring malignancy and the leading cause of cancer-related death in women. Triple-negaƟ ve breast cancer (TNBC) is the most aggressive breast cancer subtype and is associated with high recurrence rates, high incidence of distant metastases and poor overall survival. The aim of this study was to invesƟ gate the role of cludin 3, claudin 4 and claudin 7 in TNBC promoƟ on and progression. Claudins are Ɵ ght juncƟ on (TJ) integral membrane proteins that are key regulators of the paracellular pathway. Materials and methods: This is a retrospecƟ ve analysis of 125 paƟ ents with triple-negaƟ ve breast cancer operated at the InsƟ tute of Oncology and Radiology of Serbia in the period from 2009 to 2014. The expression of claudin 3, 4 and 7 was observed using the immunohistochemical staining method. The Allred scoring system was used with cut-off values: ≤4 and >4 (low/ high expression). Results: Our results showed that the expression of claudins 3 and 4 correlate with higher nuclear gradus and low desease free interval (DFI). More over, the expression of claudin 3 and claudin 4 correlates (Spearman test p˂0.0001). In addiƟ on, high expression of claudin 7 is signifi cantly related to low DFI of paƟ ents (p˂0.005) and distant metastases. Conclusions: We concluded that claudin 3, claudin 4 and claudin 7 have signifi cant impact on TNBC progression. Namely, elevated expression of these proteins signifi cantly correlates with low DFI and distant metastases. In other words, elevated expression of claudins is a bad news for TNBC paƟ ents. Therefore, the expression of claudins could be a good prognosƟ c marker for TNBC paƟ ents and potential target for future therapy protocols.",
publisher = "Belgrade : Serbian Association for Cancer Research",
journal = "Oncology Insights",
title = "Role of claudins 3,4 and 7 in triple negative breast cancer progression",
number = "1",
pages = "63-63",
url = "https://hdl.handle.net/21.15107/rcub_vinar_12633"
}

Jovanović, I., Nedeljković, M., Medić-Milijić, N., Spurnić, I., Milovanović, Z., Tomić, T., Tanić, N.,& Tanić, N.. (2023). Role of claudins 3,4 and 7 in triple negative breast cancer progression. in Oncology Insights
Belgrade : Serbian Association for Cancer Research.(1), 63-63.
https://hdl.handle.net/21.15107/rcub_vinar_12633

Jovanović I, Nedeljković M, Medić-Milijić N, Spurnić I, Milovanović Z, Tomić T, Tanić N, Tanić N. Role of claudins 3,4 and 7 in triple negative breast cancer progression. in Oncology Insights. 2023;(1):63-63.
https://hdl.handle.net/21.15107/rcub_vinar_12633 .

Jovanović, Irena, Nedeljković, Milica, Medić-Milijić, Nataša, Spurnić, Igor, Milovanović, Zorka, Tomić, Tijana, Tanić, Nasta, Tanić, Nikola, "Role of claudins 3,4 and 7 in triple negative breast cancer progression" in Oncology Insights, no. 1 (2023):63-63,
https://hdl.handle.net/21.15107/rcub_vinar_12633 .