TY  - JOUR
AU  - Gogoi, Roktim
AU  - Begum, Twahira
AU  - Sarma, Neelav
AU  - Tamang, Raghu
AU  - Chanda, Sanjoy K.
AU  - Lal, Mohan
AU  - Perveen, Kahkashan
AU  - Khan, Faheema
AU  - Marinković, Jelena
PY  - 2024
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/13099
AB  - Pelargonium graveolens L., essential oil (EO) has various therapeutic properties, including aromatherapy. The present experiment was designed to investigate chemical makeup of the P. graveolens (Geranium) EO from Northeast India using gas chromatography-mass spectroscopy (GC-MS) and gas chromatography-flame ionization detection (GC-FID), and the pharmacological potential was determined using a range of assays along with Allium cepa assay for genotoxicity study. GC-MS analysis of the EO revealed the presence of 11 compounds with a total 97.43% identified area, with citronellol (32.84%), geraniol (23.62%), and citronellyl formate (12.14%) as the major compounds. The essential oil exhibited type-II anti-diabetic properties with an IC50 6.66 μL/mL and skin whitening potential IC50 of 1.89 μL/mL. P. graveolens EO (IC50 26.16 μL/mL) was found to possess comparatively weaker anti-inflammatory agent than the standard diclofenac (IC50 9.24 μL/mL) in the protease inhibitory test. The EO demonstrated moderate antioxidant activity with an IC50 value of 22.68 μL/mL than ascorbic acid IC50 12.53 μL/mL in the ABTS assay. The EO was found to moderately affect the mitotic index (15.32%) and induce chromosomal aberrations (11.40%) at a concentration of 1 μL/mL after 72 h of exposure. Based on the findings the Northeast Indian variety of P. graveolens EO exhibits promising type-II anti-diabetic and skin whitening properties, which could be further utilized in the formulation of anti-diabetic and skin whitening agents after validation through clinical trials.
T2  - Journal of Essential Oil Bearing Plants
T1  - Pelargonium graveolens L., (Geranium) essential oil from Northeast India: chemical composition, pharmacology and genotoxicity study
VL  - 27
IS  - 1
SP  - 135
EP  - 151
DO  - 10.1080/0972060X.2024.2311825
ER  - 

@article{
author = "Gogoi, Roktim and Begum, Twahira and Sarma, Neelav and Tamang, Raghu and Chanda, Sanjoy K. and Lal, Mohan and Perveen, Kahkashan and Khan, Faheema and Marinković, Jelena",
year = "2024",
abstract = "Pelargonium graveolens L., essential oil (EO) has various therapeutic properties, including aromatherapy. The present experiment was designed to investigate chemical makeup of the P. graveolens (Geranium) EO from Northeast India using gas chromatography-mass spectroscopy (GC-MS) and gas chromatography-flame ionization detection (GC-FID), and the pharmacological potential was determined using a range of assays along with Allium cepa assay for genotoxicity study. GC-MS analysis of the EO revealed the presence of 11 compounds with a total 97.43% identified area, with citronellol (32.84%), geraniol (23.62%), and citronellyl formate (12.14%) as the major compounds. The essential oil exhibited type-II anti-diabetic properties with an IC50 6.66 μL/mL and skin whitening potential IC50 of 1.89 μL/mL. P. graveolens EO (IC50 26.16 μL/mL) was found to possess comparatively weaker anti-inflammatory agent than the standard diclofenac (IC50 9.24 μL/mL) in the protease inhibitory test. The EO demonstrated moderate antioxidant activity with an IC50 value of 22.68 μL/mL than ascorbic acid IC50 12.53 μL/mL in the ABTS assay. The EO was found to moderately affect the mitotic index (15.32%) and induce chromosomal aberrations (11.40%) at a concentration of 1 μL/mL after 72 h of exposure. Based on the findings the Northeast Indian variety of P. graveolens EO exhibits promising type-II anti-diabetic and skin whitening properties, which could be further utilized in the formulation of anti-diabetic and skin whitening agents after validation through clinical trials.",
journal = "Journal of Essential Oil Bearing Plants",
title = "Pelargonium graveolens L., (Geranium) essential oil from Northeast India: chemical composition, pharmacology and genotoxicity study",
volume = "27",
number = "1",
pages = "135-151",
doi = "10.1080/0972060X.2024.2311825"
}

Gogoi, R., Begum, T., Sarma, N., Tamang, R., Chanda, S. K., Lal, M., Perveen, K., Khan, F.,& Marinković, J.. (2024). Pelargonium graveolens L., (Geranium) essential oil from Northeast India: chemical composition, pharmacology and genotoxicity study. in Journal of Essential Oil Bearing Plants, 27(1), 135-151.
https://doi.org/10.1080/0972060X.2024.2311825

Gogoi R, Begum T, Sarma N, Tamang R, Chanda SK, Lal M, Perveen K, Khan F, Marinković J. Pelargonium graveolens L., (Geranium) essential oil from Northeast India: chemical composition, pharmacology and genotoxicity study. in Journal of Essential Oil Bearing Plants. 2024;27(1):135-151.
doi:10.1080/0972060X.2024.2311825 .

Gogoi, Roktim, Begum, Twahira, Sarma, Neelav, Tamang, Raghu, Chanda, Sanjoy K., Lal, Mohan, Perveen, Kahkashan, Khan, Faheema, Marinković, Jelena, "Pelargonium graveolens L., (Geranium) essential oil from Northeast India: chemical composition, pharmacology and genotoxicity study" in Journal of Essential Oil Bearing Plants, 27, no. 1 (2024):135-151,
https://doi.org/10.1080/0972060X.2024.2311825 . .

TY  - JOUR
AU  - Choubey, Vikash Kumar
AU  - Gupta, Tanmita
AU  - Gogoi, Roktim
AU  - Tamang, Raghu
AU  - Sarma, Neelav
AU  - Begum, Twahira
AU  - Lal, Mohan
AU  - Dutta, Dipanka
AU  - Perveen, Kahkashan
AU  - Khan, Faheema
AU  - Marinković, Jelena
PY  - 2023
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/12048
AB  - Ocimum americanum L. is a highly valued aromatic plant whose leaves are used not only in traditional cuisine but also in the food, cosmetic, and pharmaceutical industries. This study aimed to identify the chemical profile of essential oil extracted from the leaves of Ocimum americanum by GC-FID and GC/MS grown in acidic soil conditions in the NE region of India. Furthermore, the biological activities like antioxidant, anti-diabetic, anti-inflammatory, and anti-tyrosinase activity were analyzed, as per standard methods. GC and GC/MS analysis identified 16 compounds in which citral-a (48.25%) was found as a major compound, followed by carveol (41.64%). The antioxidant activity was performed using DPPH and ABTS methods; and IC50 value obtained was 8.85 μL/mL and 28.82 μL/mL, respectively. The leaf essential oil of O. americanum exhibited strong anti-diabetic and anti-inflammatory activities, whereas moderate anti-tyrosinase activities with IC50 values of 40.84, 12.81, and 182.74 μL/mL, respectively. Furthermore, the ant-microbial activity was evaluated for four bacterial and four fungal strains, revealing that O. americanum essential oil expresses antifungal activity against S. cereviaceae only with a MIC value of 5±0.47 μg/mL. These evidences clearly indicates that essential oil obtained from the leaf of O. americanum showed potential anti-inflammatory and anti-diabetic activity that can be used as an alternative in pharmaceuticals and food industries as a natural source.
T2  - Journal of Essential Oil Bearing Plants
T1  - Chemical compositions and different biological activity of leaf essential oil of                    Ocimum americanum                    L. grown in acidic soil conditions
SP  - 1
EP  - 13
DO  - 10.1080/0972060X.2023.2278751
ER  - 

@article{
author = "Choubey, Vikash Kumar and Gupta, Tanmita and Gogoi, Roktim and Tamang, Raghu and Sarma, Neelav and Begum, Twahira and Lal, Mohan and Dutta, Dipanka and Perveen, Kahkashan and Khan, Faheema and Marinković, Jelena",
year = "2023",
abstract = "Ocimum americanum L. is a highly valued aromatic plant whose leaves are used not only in traditional cuisine but also in the food, cosmetic, and pharmaceutical industries. This study aimed to identify the chemical profile of essential oil extracted from the leaves of Ocimum americanum by GC-FID and GC/MS grown in acidic soil conditions in the NE region of India. Furthermore, the biological activities like antioxidant, anti-diabetic, anti-inflammatory, and anti-tyrosinase activity were analyzed, as per standard methods. GC and GC/MS analysis identified 16 compounds in which citral-a (48.25%) was found as a major compound, followed by carveol (41.64%). The antioxidant activity was performed using DPPH and ABTS methods; and IC50 value obtained was 8.85 μL/mL and 28.82 μL/mL, respectively. The leaf essential oil of O. americanum exhibited strong anti-diabetic and anti-inflammatory activities, whereas moderate anti-tyrosinase activities with IC50 values of 40.84, 12.81, and 182.74 μL/mL, respectively. Furthermore, the ant-microbial activity was evaluated for four bacterial and four fungal strains, revealing that O. americanum essential oil expresses antifungal activity against S. cereviaceae only with a MIC value of 5±0.47 μg/mL. These evidences clearly indicates that essential oil obtained from the leaf of O. americanum showed potential anti-inflammatory and anti-diabetic activity that can be used as an alternative in pharmaceuticals and food industries as a natural source.",
journal = "Journal of Essential Oil Bearing Plants",
title = "Chemical compositions and different biological activity of leaf essential oil of                    Ocimum americanum                    L. grown in acidic soil conditions",
pages = "1-13",
doi = "10.1080/0972060X.2023.2278751"
}

Choubey, V. K., Gupta, T., Gogoi, R., Tamang, R., Sarma, N., Begum, T., Lal, M., Dutta, D., Perveen, K., Khan, F.,& Marinković, J.. (2023). Chemical compositions and different biological activity of leaf essential oil of                    Ocimum americanum                    L. grown in acidic soil conditions. in Journal of Essential Oil Bearing Plants, 1-13.
https://doi.org/10.1080/0972060X.2023.2278751

Choubey VK, Gupta T, Gogoi R, Tamang R, Sarma N, Begum T, Lal M, Dutta D, Perveen K, Khan F, Marinković J. Chemical compositions and different biological activity of leaf essential oil of                    Ocimum americanum                    L. grown in acidic soil conditions. in Journal of Essential Oil Bearing Plants. 2023;:1-13.
doi:10.1080/0972060X.2023.2278751 .

Choubey, Vikash Kumar, Gupta, Tanmita, Gogoi, Roktim, Tamang, Raghu, Sarma, Neelav, Begum, Twahira, Lal, Mohan, Dutta, Dipanka, Perveen, Kahkashan, Khan, Faheema, Marinković, Jelena, "Chemical compositions and different biological activity of leaf essential oil of                    Ocimum americanum                    L. grown in acidic soil conditions" in Journal of Essential Oil Bearing Plants (2023):1-13,
https://doi.org/10.1080/0972060X.2023.2278751 . .