TY  - JOUR
AU  - Suljovrujić, Edin H.
AU  - Krstić, Maja
AU  - Rogić Miladinović, Zorana
AU  - Petrović, Sandra
AU  - Leskovac, Andreja
AU  - Stamboliev, Georgi
PY  - 2023
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/11063
AB  - Hydrogels with oligo(ethylene glycol) (OEG), oligo(propylene glycol) (OPG), and for the first time with combined OEG/OPG pendant chains within the methacrylate (MA) network, were synthesized and the swelling behavior, thermal properties, microstructure, and genotoxicity were investigated. Prior to hydrogel fabrication, an optimized method was developed for oligo(propylene glycol) methacrylate (OPGMA), i.e., oligomer with an LCST below a temperature at which synthesis occurs, indicating that proper preparation and tuning of reaction conditions were required. PEG6MA and PPG5MA homopolymers, as well as P(EG6/PG5)MA copolymer hydrogel, were produced by gamma radiation-induced polymerization and crosslinking of OEG and OPG monomers from the monomer-solvent mixture by using different water/ethanol composition as a solvent and by exposing the reaction mixture to various radiation doses. The combination of OEG and OPG pendant chains within the same network was advantageous in that it allowed an easy tuning of the phase transition temperature. Thus, the volume phase transition (VPT) at temperatures above 70 °C observed in the case of PEG6MA, and in the case of PPG5MA at temperatures below 15 °C, could easily be tuned close to physiological temperatures for P(EG6/PG5)MA hydrogel. Finally, all obtained thermoresponsive hydrogels showed non-genotoxic and non-cytotoxic properties, which indicate promising potential for biomedical applications.
T2  - Reactive and Functional Polymers
T1  - Optimization of thermoresponsive hydrogels based on oligomers with lower critical solution temperature (LCST) far below/above physiological temperatures for biomedical applications
VL  - 189
SP  - 105612
DO  - 10.1016/j.reactfunctpolym.2023.105612
ER  - 

@article{
author = "Suljovrujić, Edin H. and Krstić, Maja and Rogić Miladinović, Zorana and Petrović, Sandra and Leskovac, Andreja and Stamboliev, Georgi",
year = "2023",
abstract = "Hydrogels with oligo(ethylene glycol) (OEG), oligo(propylene glycol) (OPG), and for the first time with combined OEG/OPG pendant chains within the methacrylate (MA) network, were synthesized and the swelling behavior, thermal properties, microstructure, and genotoxicity were investigated. Prior to hydrogel fabrication, an optimized method was developed for oligo(propylene glycol) methacrylate (OPGMA), i.e., oligomer with an LCST below a temperature at which synthesis occurs, indicating that proper preparation and tuning of reaction conditions were required. PEG6MA and PPG5MA homopolymers, as well as P(EG6/PG5)MA copolymer hydrogel, were produced by gamma radiation-induced polymerization and crosslinking of OEG and OPG monomers from the monomer-solvent mixture by using different water/ethanol composition as a solvent and by exposing the reaction mixture to various radiation doses. The combination of OEG and OPG pendant chains within the same network was advantageous in that it allowed an easy tuning of the phase transition temperature. Thus, the volume phase transition (VPT) at temperatures above 70 °C observed in the case of PEG6MA, and in the case of PPG5MA at temperatures below 15 °C, could easily be tuned close to physiological temperatures for P(EG6/PG5)MA hydrogel. Finally, all obtained thermoresponsive hydrogels showed non-genotoxic and non-cytotoxic properties, which indicate promising potential for biomedical applications.",
journal = "Reactive and Functional Polymers",
title = "Optimization of thermoresponsive hydrogels based on oligomers with lower critical solution temperature (LCST) far below/above physiological temperatures for biomedical applications",
volume = "189",
pages = "105612",
doi = "10.1016/j.reactfunctpolym.2023.105612"
}

Suljovrujić, E. H., Krstić, M., Rogić Miladinović, Z., Petrović, S., Leskovac, A.,& Stamboliev, G.. (2023). Optimization of thermoresponsive hydrogels based on oligomers with lower critical solution temperature (LCST) far below/above physiological temperatures for biomedical applications. in Reactive and Functional Polymers, 189, 105612.
https://doi.org/10.1016/j.reactfunctpolym.2023.105612

Suljovrujić EH, Krstić M, Rogić Miladinović Z, Petrović S, Leskovac A, Stamboliev G. Optimization of thermoresponsive hydrogels based on oligomers with lower critical solution temperature (LCST) far below/above physiological temperatures for biomedical applications. in Reactive and Functional Polymers. 2023;189:105612.
doi:10.1016/j.reactfunctpolym.2023.105612 .

Suljovrujić, Edin H., Krstić, Maja, Rogić Miladinović, Zorana, Petrović, Sandra, Leskovac, Andreja, Stamboliev, Georgi, "Optimization of thermoresponsive hydrogels based on oligomers with lower critical solution temperature (LCST) far below/above physiological temperatures for biomedical applications" in Reactive and Functional Polymers, 189 (2023):105612,
https://doi.org/10.1016/j.reactfunctpolym.2023.105612 . .

TY  - JOUR
AU  - Leskovac, Andreja
AU  - Petrović, Sandra
PY  - 2023
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/11388
AB  - While recognizing the gaps in pesticide regulations that impact consumer safety, public health concerns associated with pesticide contamination of foods are pointed out. The strategies and research directions proposed to prevent and/or reduce pesticide adverse effects on human health and the environment are discussed. Special attention is paid to organophosphate pesticides, as widely applied insecticides in agriculture, veterinary practices, and urban areas. Biotic and abiotic strategies for organophosphate pesticide degradation are discussed from a food safety perspective, indicating associated challenges and potential for further improvements. As food systems are endangered globally by unprecedented challenges, there is an urgent need to globally harmonize pesticide regulations and improve methodologies in the area of food safety to protect human health.
T2  - Foods
T1  - Pesticide Use and Degradation Strategies: Food Safety, Challenges and Perspectives
VL  - 12
IS  - 14
SP  - 2709
DO  - 10.3390/foods12142709
ER  - 

@article{
author = "Leskovac, Andreja and Petrović, Sandra",
year = "2023",
abstract = "While recognizing the gaps in pesticide regulations that impact consumer safety, public health concerns associated with pesticide contamination of foods are pointed out. The strategies and research directions proposed to prevent and/or reduce pesticide adverse effects on human health and the environment are discussed. Special attention is paid to organophosphate pesticides, as widely applied insecticides in agriculture, veterinary practices, and urban areas. Biotic and abiotic strategies for organophosphate pesticide degradation are discussed from a food safety perspective, indicating associated challenges and potential for further improvements. As food systems are endangered globally by unprecedented challenges, there is an urgent need to globally harmonize pesticide regulations and improve methodologies in the area of food safety to protect human health.",
journal = "Foods",
title = "Pesticide Use and Degradation Strategies: Food Safety, Challenges and Perspectives",
volume = "12",
number = "14",
pages = "2709",
doi = "10.3390/foods12142709"
}

Leskovac, A.,& Petrović, S.. (2023). Pesticide Use and Degradation Strategies: Food Safety, Challenges and Perspectives. in Foods, 12(14), 2709.
https://doi.org/10.3390/foods12142709

Leskovac A, Petrović S. Pesticide Use and Degradation Strategies: Food Safety, Challenges and Perspectives. in Foods. 2023;12(14):2709.
doi:10.3390/foods12142709 .

Leskovac, Andreja, Petrović, Sandra, "Pesticide Use and Degradation Strategies: Food Safety, Challenges and Perspectives" in Foods, 12, no. 14 (2023):2709,
https://doi.org/10.3390/foods12142709 . .

TY  - CHAP
AU  - Leskovac, Andreja
PY  - 2023
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/12049
AB  - Phospholipases A2 (PLA2) is a superfamily of esterase enzymes essential for the maintenance of cellular homeostasis. PLA2s are involved in a variety of physiological processes, as well as pathological conditions, where their function is disrupted. Disruption of PLA2-regulated metabolism has been linked with severe pathological conditions, including rheumatoid arthritis, cardiovascular diseases, neurological disorders, and cancer. Therefore, the search for effective and selective PLA2 inhibitors is of particular importance for treating pathological conditions where PLA2s are involved, as well as elucidating their functions. Although numerous bioactive compounds from diverse sources, such as plants, marine organisms, and animal sera, are reported as efficient inhibitors of PLA2, none of the PLA2 inhibitors have been successful in clinical trials thus far. Therefore, future research should be directed primarily toward developing selective PLA2 inhibitors that will act on transduction pathways in a targeted manner.
PB  - Elsevier
T2  - Phospholipases in Physiology and Pathology
T1  - Natural inhibitors of phospholipase A2: Current knowledge and therapeutic approaches
VL  - 5
SP  - 67
EP  - 77
DO  - 10.1016/B978-0-323-95699-4.00015-3
ER  - 

@inbook{
author = "Leskovac, Andreja",
year = "2023",
abstract = "Phospholipases A2 (PLA2) is a superfamily of esterase enzymes essential for the maintenance of cellular homeostasis. PLA2s are involved in a variety of physiological processes, as well as pathological conditions, where their function is disrupted. Disruption of PLA2-regulated metabolism has been linked with severe pathological conditions, including rheumatoid arthritis, cardiovascular diseases, neurological disorders, and cancer. Therefore, the search for effective and selective PLA2 inhibitors is of particular importance for treating pathological conditions where PLA2s are involved, as well as elucidating their functions. Although numerous bioactive compounds from diverse sources, such as plants, marine organisms, and animal sera, are reported as efficient inhibitors of PLA2, none of the PLA2 inhibitors have been successful in clinical trials thus far. Therefore, future research should be directed primarily toward developing selective PLA2 inhibitors that will act on transduction pathways in a targeted manner.",
publisher = "Elsevier",
journal = "Phospholipases in Physiology and Pathology",
booktitle = "Natural inhibitors of phospholipase A2: Current knowledge and therapeutic approaches",
volume = "5",
pages = "67-77",
doi = "10.1016/B978-0-323-95699-4.00015-3"
}

Leskovac, A.. (2023). Natural inhibitors of phospholipase A2: Current knowledge and therapeutic approaches. in Phospholipases in Physiology and Pathology
Elsevier., 5, 67-77.
https://doi.org/10.1016/B978-0-323-95699-4.00015-3

Leskovac A. Natural inhibitors of phospholipase A2: Current knowledge and therapeutic approaches. in Phospholipases in Physiology and Pathology. 2023;5:67-77.
doi:10.1016/B978-0-323-95699-4.00015-3 .

Leskovac, Andreja, "Natural inhibitors of phospholipase A2: Current knowledge and therapeutic approaches" in Phospholipases in Physiology and Pathology, 5 (2023):67-77,
https://doi.org/10.1016/B978-0-323-95699-4.00015-3 . .

TY  - CHAP
AU  - Petrović, Sandra
AU  - Leskovac, Andreja
PY  - 2022
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10649
AB  - While recognizing the differences in the pathogenesis of different malignancies, the outstanding body of evidence has been accumulated in the past few decades, implicating the role of oxidative stress in the process of cancer initiation and progression. Cancer cells exhibit an altered energy metabolism and highly efficient redox systems that enable rapid cell proliferation and survival in various conditions. The adaptation/resistance of cancer cells to chronic oxidative stress through different mechanisms usually leads to drug resistance. The specific disruption of the redox capacity with either scavenging the excessive intracellular ROS or inducing ROS generation through exogenous oxidative insult represents a promising approach for cancer therapy. A considerable research effort has been dedicated to identifying the therapeutic agents with redox-modulation capacity that may impede cancer. Based on the established knowledge in these subjects, the natural and synthetic redox modulators currently used or under investigation for their potential application in the oxidative stress-targeted cancer therapy are reviewed.
T2  - Handbook of Oxidative Stress in Cancer: Mechanistic Aspects
T1  - Prospective Application of Natural and Synthetic Redox Modulators in Oxidative Stress-Targeted Cancer Therapy
SP  - 2101
EP  - 2121
DO  - 10.1007/978-981-15-9411-3_130
ER  - 

@inbook{
author = "Petrović, Sandra and Leskovac, Andreja",
year = "2022",
abstract = "While recognizing the differences in the pathogenesis of different malignancies, the outstanding body of evidence has been accumulated in the past few decades, implicating the role of oxidative stress in the process of cancer initiation and progression. Cancer cells exhibit an altered energy metabolism and highly efficient redox systems that enable rapid cell proliferation and survival in various conditions. The adaptation/resistance of cancer cells to chronic oxidative stress through different mechanisms usually leads to drug resistance. The specific disruption of the redox capacity with either scavenging the excessive intracellular ROS or inducing ROS generation through exogenous oxidative insult represents a promising approach for cancer therapy. A considerable research effort has been dedicated to identifying the therapeutic agents with redox-modulation capacity that may impede cancer. Based on the established knowledge in these subjects, the natural and synthetic redox modulators currently used or under investigation for their potential application in the oxidative stress-targeted cancer therapy are reviewed.",
journal = "Handbook of Oxidative Stress in Cancer: Mechanistic Aspects",
booktitle = "Prospective Application of Natural and Synthetic Redox Modulators in Oxidative Stress-Targeted Cancer Therapy",
pages = "2101-2121",
doi = "10.1007/978-981-15-9411-3_130"
}

Petrović, S.,& Leskovac, A.. (2022). Prospective Application of Natural and Synthetic Redox Modulators in Oxidative Stress-Targeted Cancer Therapy. in Handbook of Oxidative Stress in Cancer: Mechanistic Aspects, 2101-2121.
https://doi.org/10.1007/978-981-15-9411-3_130

Petrović S, Leskovac A. Prospective Application of Natural and Synthetic Redox Modulators in Oxidative Stress-Targeted Cancer Therapy. in Handbook of Oxidative Stress in Cancer: Mechanistic Aspects. 2022;:2101-2121.
doi:10.1007/978-981-15-9411-3_130 .

Petrović, Sandra, Leskovac, Andreja, "Prospective Application of Natural and Synthetic Redox Modulators in Oxidative Stress-Targeted Cancer Therapy" in Handbook of Oxidative Stress in Cancer: Mechanistic Aspects (2022):2101-2121,
https://doi.org/10.1007/978-981-15-9411-3_130 . .

TY  - CONF
AU  - Valenta Šobot, Ana
AU  - Filipović Tričković, Jelena
AU  - Drakulić, Dunja
AU  - Leskovac, Andreja
AU  - Petrović, Sandra
AU  - Momić, Tatjana
PY  - 2022
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/11582
AB  - Sweroside (Sw) is a secondary metabolite commonly found in plants belonging to the Gentianaceae family [1]. This iridoid compound is well-known for its anti-inflammatory [2], antidiabetic [3] and antitumor properties [4], which have been studied in pathological model systems. In transformed cell lines, Sw displays an antitumor effect by apoptosis activation [5]. Since healthy cells are also exposed to cancer therapy applied in vivo, our goal was to determine Sw’s cytotoxic concentration in primary human peripheral blood mononuclear cells (PBMCs) after 48 h of treatment with a range of concentration from 20 μM to 130 μM Sw in vitro, and to analyze whether the cytotoxic effect was due to activated apoptosis. According to the obtained results of the trypan blue dye exclusion test, 48 h of treatment with 50 μM Sw and higher concentrations led to a significant decrease in cell number. The DNA fragmentation assay indicated that following 50 μM Sw treatment, cells are dying in an apoptosis-like manner since the level of DNA fragments was 3.5 times higher than in the untreated control. The type of cell death was confirmed by immunoblot analysis of apoptosis- specific protein markers, which revealed the elevation of cleaved caspase-3 and PARP1 89 kDa fragments. Our findings showed that like in transformed cell lines, Sw in healthy cells can also activate apoptosis. A potential difference in sensitivity to Sw treatment between healthy and transformed cells could justify Sw treatment in anticancer therapy.
PB  - Belgrade : University of Belgrade, Faculty of Agriculture
C3  - 1-EuSPMF - 1st European symposium on phytochemicals in medicine and food : Book of abstracts
T1  - Sweroside displays a cytotoxic effect by activating apoptosis in human peripheral blood mononuclear cells
SP  - 47
EP  - 47
UR  - https://hdl.handle.net/21.15107/rcub_vinar_11582
ER  - 

@conference{
author = "Valenta Šobot, Ana and Filipović Tričković, Jelena and Drakulić, Dunja and Leskovac, Andreja and Petrović, Sandra and Momić, Tatjana",
year = "2022",
abstract = "Sweroside (Sw) is a secondary metabolite commonly found in plants belonging to the Gentianaceae family [1]. This iridoid compound is well-known for its anti-inflammatory [2], antidiabetic [3] and antitumor properties [4], which have been studied in pathological model systems. In transformed cell lines, Sw displays an antitumor effect by apoptosis activation [5]. Since healthy cells are also exposed to cancer therapy applied in vivo, our goal was to determine Sw’s cytotoxic concentration in primary human peripheral blood mononuclear cells (PBMCs) after 48 h of treatment with a range of concentration from 20 μM to 130 μM Sw in vitro, and to analyze whether the cytotoxic effect was due to activated apoptosis. According to the obtained results of the trypan blue dye exclusion test, 48 h of treatment with 50 μM Sw and higher concentrations led to a significant decrease in cell number. The DNA fragmentation assay indicated that following 50 μM Sw treatment, cells are dying in an apoptosis-like manner since the level of DNA fragments was 3.5 times higher than in the untreated control. The type of cell death was confirmed by immunoblot analysis of apoptosis- specific protein markers, which revealed the elevation of cleaved caspase-3 and PARP1 89 kDa fragments. Our findings showed that like in transformed cell lines, Sw in healthy cells can also activate apoptosis. A potential difference in sensitivity to Sw treatment between healthy and transformed cells could justify Sw treatment in anticancer therapy.",
publisher = "Belgrade : University of Belgrade, Faculty of Agriculture",
journal = "1-EuSPMF - 1st European symposium on phytochemicals in medicine and food : Book of abstracts",
title = "Sweroside displays a cytotoxic effect by activating apoptosis in human peripheral blood mononuclear cells",
pages = "47-47",
url = "https://hdl.handle.net/21.15107/rcub_vinar_11582"
}

Valenta Šobot, A., Filipović Tričković, J., Drakulić, D., Leskovac, A., Petrović, S.,& Momić, T.. (2022). Sweroside displays a cytotoxic effect by activating apoptosis in human peripheral blood mononuclear cells. in 1-EuSPMF - 1st European symposium on phytochemicals in medicine and food : Book of abstracts
Belgrade : University of Belgrade, Faculty of Agriculture., 47-47.
https://hdl.handle.net/21.15107/rcub_vinar_11582

Valenta Šobot A, Filipović Tričković J, Drakulić D, Leskovac A, Petrović S, Momić T. Sweroside displays a cytotoxic effect by activating apoptosis in human peripheral blood mononuclear cells. in 1-EuSPMF - 1st European symposium on phytochemicals in medicine and food : Book of abstracts. 2022;:47-47.
https://hdl.handle.net/21.15107/rcub_vinar_11582 .

Valenta Šobot, Ana, Filipović Tričković, Jelena, Drakulić, Dunja, Leskovac, Andreja, Petrović, Sandra, Momić, Tatjana, "Sweroside displays a cytotoxic effect by activating apoptosis in human peripheral blood mononuclear cells" in 1-EuSPMF - 1st European symposium on phytochemicals in medicine and food : Book of abstracts (2022):47-47,
https://hdl.handle.net/21.15107/rcub_vinar_11582 .

TY  - CONF
AU  - Valenta Šobot, Ana
AU  - Filipović Tričković, Jelena
AU  - Leskovac, Andreja
AU  - Petrović, Sandra
AU  - Momić, Tatjana
PY  - 2022
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/11583
AB  - Quercetin (Q) is one of the most common and well researched antioxidant flavonoids, which usually occurs in plant-based foods, and medicinal plants. It was shown that quercetin exerts many beneficial effects on human health, including prevention of cancer and heart diseases. Quercetin was found to be toxic toward various types of cancer cell, still, at higher concentrations it was also shown toxic toward normal human cells [1,2]. One of the approaches to overcome this shortcoming offers nanotechnology which enables the novel perspective of phytochemical usage in contemporary medicine [3]. The strategy of binding quercetin to the gold nanoparticles during their synthesis was used, which resulted in quercetin capped gold nanoparticles (NPQ) [4]. Trypan blue exclusion test [5] was used to evaluate peripheral blood mononuclear cells (PBMC) viability after their exposure to either NPQ or free Q during 24, 48 and 72 h, at 37 °C, in the range of quercetin concentrations from 5 to 50 μg/mL. A significant reduction in the cell count was observed in PBMC cultures treated with 10, 20, and 50 μg/mL of free Q, for all exposure times. The treatments of increasing concentrations and exposure times lowered the cells viability, resulting in 63% of the viable cells, following 72 h of the treatment with 50 μg/mL of free Q. Although NPQ treatments affected the cells viability in a concentration- and time-dependent manner the treatment with 50 μg/mL of NPQ for 72 h, had a milder effect on PBMC cultures than free Q, resulting in 81% of the viable cells (Figure 1). According to the obtained results, NPQ were shown less toxic toward PBMC than free Q.
PB  - Belgrade : University of Belgrade, Faculty of Agriculture
C3  - 1-EuSPMF - 1st European symposium on phytochemicals in medicine and food : Book of abstracts
T1  - Nanotechnology approach for diminishing quercetin toxicity toward peripheral blood mononuclear cells
SP  - 64
EP  - 64
UR  - https://hdl.handle.net/21.15107/rcub_vinar_11583
ER  - 

@conference{
author = "Valenta Šobot, Ana and Filipović Tričković, Jelena and Leskovac, Andreja and Petrović, Sandra and Momić, Tatjana",
year = "2022",
abstract = "Quercetin (Q) is one of the most common and well researched antioxidant flavonoids, which usually occurs in plant-based foods, and medicinal plants. It was shown that quercetin exerts many beneficial effects on human health, including prevention of cancer and heart diseases. Quercetin was found to be toxic toward various types of cancer cell, still, at higher concentrations it was also shown toxic toward normal human cells [1,2]. One of the approaches to overcome this shortcoming offers nanotechnology which enables the novel perspective of phytochemical usage in contemporary medicine [3]. The strategy of binding quercetin to the gold nanoparticles during their synthesis was used, which resulted in quercetin capped gold nanoparticles (NPQ) [4]. Trypan blue exclusion test [5] was used to evaluate peripheral blood mononuclear cells (PBMC) viability after their exposure to either NPQ or free Q during 24, 48 and 72 h, at 37 °C, in the range of quercetin concentrations from 5 to 50 μg/mL. A significant reduction in the cell count was observed in PBMC cultures treated with 10, 20, and 50 μg/mL of free Q, for all exposure times. The treatments of increasing concentrations and exposure times lowered the cells viability, resulting in 63% of the viable cells, following 72 h of the treatment with 50 μg/mL of free Q. Although NPQ treatments affected the cells viability in a concentration- and time-dependent manner the treatment with 50 μg/mL of NPQ for 72 h, had a milder effect on PBMC cultures than free Q, resulting in 81% of the viable cells (Figure 1). According to the obtained results, NPQ were shown less toxic toward PBMC than free Q.",
publisher = "Belgrade : University of Belgrade, Faculty of Agriculture",
journal = "1-EuSPMF - 1st European symposium on phytochemicals in medicine and food : Book of abstracts",
title = "Nanotechnology approach for diminishing quercetin toxicity toward peripheral blood mononuclear cells",
pages = "64-64",
url = "https://hdl.handle.net/21.15107/rcub_vinar_11583"
}

Valenta Šobot, A., Filipović Tričković, J., Leskovac, A., Petrović, S.,& Momić, T.. (2022). Nanotechnology approach for diminishing quercetin toxicity toward peripheral blood mononuclear cells. in 1-EuSPMF - 1st European symposium on phytochemicals in medicine and food : Book of abstracts
Belgrade : University of Belgrade, Faculty of Agriculture., 64-64.
https://hdl.handle.net/21.15107/rcub_vinar_11583

Valenta Šobot A, Filipović Tričković J, Leskovac A, Petrović S, Momić T. Nanotechnology approach for diminishing quercetin toxicity toward peripheral blood mononuclear cells. in 1-EuSPMF - 1st European symposium on phytochemicals in medicine and food : Book of abstracts. 2022;:64-64.
https://hdl.handle.net/21.15107/rcub_vinar_11583 .

Valenta Šobot, Ana, Filipović Tričković, Jelena, Leskovac, Andreja, Petrović, Sandra, Momić, Tatjana, "Nanotechnology approach for diminishing quercetin toxicity toward peripheral blood mononuclear cells" in 1-EuSPMF - 1st European symposium on phytochemicals in medicine and food : Book of abstracts (2022):64-64,
https://hdl.handle.net/21.15107/rcub_vinar_11583 .

TY  - CHAP
AU  - Leskovac, Andreja
PY  - 2022
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10650
AB  - Pesticides are used in almost all food production areas and represent pollutants of worldwide importance. The utilization of organophosphate (OP) pesticides is considered a major global health problem. The OP pesticides toxicity is closely related to their metabolism, oxidative stress induction, mitochondrial dysfunction, and inhibition of the enzyme acetylcholinesterase (AChE). OP pesticides affect cellular and molecular targets, which may lead to systemic disturbances and, finally, the development of various human diseases. The extent and severity of OPsinduced adverse effects depend not only on the specific pesticide properties, exposure levels, and route of absorption but also on polymorphisms in the main genes involved in OP metabolism. This chapter aims to provide insight into the cytotoxic and genotoxic effects of OP pesticides in humans, their metabolism, mechanisms of action, and the potential treatment strategies to minimize their possible effects on the environment and human health.
T2  - Organophosphates: Detection, Exposure and Occurrence. Volume 1: Impact on Health and the Natural Environment
T1  - Organophosphate Pesticides: Cytotoxicity, Genotoxicity and Current Treatment Strategies
SP  - 27
EP  - 62
UR  - https://hdl.handle.net/21.15107/rcub_vinar_10650
ER  - 

@inbook{
author = "Leskovac, Andreja",
year = "2022",
abstract = "Pesticides are used in almost all food production areas and represent pollutants of worldwide importance. The utilization of organophosphate (OP) pesticides is considered a major global health problem. The OP pesticides toxicity is closely related to their metabolism, oxidative stress induction, mitochondrial dysfunction, and inhibition of the enzyme acetylcholinesterase (AChE). OP pesticides affect cellular and molecular targets, which may lead to systemic disturbances and, finally, the development of various human diseases. The extent and severity of OPsinduced adverse effects depend not only on the specific pesticide properties, exposure levels, and route of absorption but also on polymorphisms in the main genes involved in OP metabolism. This chapter aims to provide insight into the cytotoxic and genotoxic effects of OP pesticides in humans, their metabolism, mechanisms of action, and the potential treatment strategies to minimize their possible effects on the environment and human health.",
journal = "Organophosphates: Detection, Exposure and Occurrence. Volume 1: Impact on Health and the Natural Environment",
booktitle = "Organophosphate Pesticides: Cytotoxicity, Genotoxicity and Current Treatment Strategies",
pages = "27-62",
url = "https://hdl.handle.net/21.15107/rcub_vinar_10650"
}

Leskovac, A.. (2022). Organophosphate Pesticides: Cytotoxicity, Genotoxicity and Current Treatment Strategies. in Organophosphates: Detection, Exposure and Occurrence. Volume 1: Impact on Health and the Natural Environment, 27-62.
https://hdl.handle.net/21.15107/rcub_vinar_10650

Leskovac A. Organophosphate Pesticides: Cytotoxicity, Genotoxicity and Current Treatment Strategies. in Organophosphates: Detection, Exposure and Occurrence. Volume 1: Impact on Health and the Natural Environment. 2022;:27-62.
https://hdl.handle.net/21.15107/rcub_vinar_10650 .

Leskovac, Andreja, "Organophosphate Pesticides: Cytotoxicity, Genotoxicity and Current Treatment Strategies" in Organophosphates: Detection, Exposure and Occurrence. Volume 1: Impact on Health and the Natural Environment (2022):27-62,
https://hdl.handle.net/21.15107/rcub_vinar_10650 .

TY  - CONF
AU  - Čolović, Mirjana
AU  - Leskovac, Andreja
AU  - Vujačić Nikezić, Ana V.
AU  - Krstić, Danijela
PY  - 2021
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/11688
PB  - Belgrade : Vinča Institute of Nuclear Sciences
C3  - 7th Workshop Specific Methods for Food Safety and Quality, September 22nd, 2021, Belgrade, Serbia, 15th International Conference on Fundamental and Applied Aspects of Physical Chemistry - Physical Chemistry
T1  - In Vitro Evaluation of Chlorpyrifos Cytotoxic Effects
SP  - 135
EP  - 138
UR  - https://hdl.handle.net/21.15107/rcub_vinar_11688
ER  - 

@conference{
author = "Čolović, Mirjana and Leskovac, Andreja and Vujačić Nikezić, Ana V. and Krstić, Danijela",
year = "2021",
publisher = "Belgrade : Vinča Institute of Nuclear Sciences",
journal = "7th Workshop Specific Methods for Food Safety and Quality, September 22nd, 2021, Belgrade, Serbia, 15th International Conference on Fundamental and Applied Aspects of Physical Chemistry - Physical Chemistry",
title = "In Vitro Evaluation of Chlorpyrifos Cytotoxic Effects",
pages = "135-138",
url = "https://hdl.handle.net/21.15107/rcub_vinar_11688"
}

Čolović, M., Leskovac, A., Vujačić Nikezić, A. V.,& Krstić, D.. (2021). In Vitro Evaluation of Chlorpyrifos Cytotoxic Effects. in 7th Workshop Specific Methods for Food Safety and Quality, September 22nd, 2021, Belgrade, Serbia, 15th International Conference on Fundamental and Applied Aspects of Physical Chemistry - Physical Chemistry
Belgrade : Vinča Institute of Nuclear Sciences., 135-138.
https://hdl.handle.net/21.15107/rcub_vinar_11688

Čolović M, Leskovac A, Vujačić Nikezić AV, Krstić D. In Vitro Evaluation of Chlorpyrifos Cytotoxic Effects. in 7th Workshop Specific Methods for Food Safety and Quality, September 22nd, 2021, Belgrade, Serbia, 15th International Conference on Fundamental and Applied Aspects of Physical Chemistry - Physical Chemistry. 2021;:135-138.
https://hdl.handle.net/21.15107/rcub_vinar_11688 .

Čolović, Mirjana, Leskovac, Andreja, Vujačić Nikezić, Ana V., Krstić, Danijela, "In Vitro Evaluation of Chlorpyrifos Cytotoxic Effects" in 7th Workshop Specific Methods for Food Safety and Quality, September 22nd, 2021, Belgrade, Serbia, 15th International Conference on Fundamental and Applied Aspects of Physical Chemistry - Physical Chemistry (2021):135-138,
https://hdl.handle.net/21.15107/rcub_vinar_11688 .

TY  - CONF
AU  - Leskovac, Andreja
AU  - Čolović, Mirjana
AU  - Bondžić, Aleksandra
AU  - Petrović, Sandra
PY  - 2021
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/11686
PB  - Belgrade : Vinča Institute of Nuclear Sciences
C3  - 7th Workshop Specific Methods for Food Safety and Quality, September 22nd, 2021, Belgrade, Serbia, 15th International Conference on Fundamental and Applied Aspects of Physical Chemistry - Physical Chemistry
T1  - N-Acetylcysteine as Regulator of the Cellular Homeostasis
SP  - 192
EP  - 195
UR  - https://hdl.handle.net/21.15107/rcub_vinar_11686
ER  - 

@conference{
author = "Leskovac, Andreja and Čolović, Mirjana and Bondžić, Aleksandra and Petrović, Sandra",
year = "2021",
publisher = "Belgrade : Vinča Institute of Nuclear Sciences",
journal = "7th Workshop Specific Methods for Food Safety and Quality, September 22nd, 2021, Belgrade, Serbia, 15th International Conference on Fundamental and Applied Aspects of Physical Chemistry - Physical Chemistry",
title = "N-Acetylcysteine as Regulator of the Cellular Homeostasis",
pages = "192-195",
url = "https://hdl.handle.net/21.15107/rcub_vinar_11686"
}

Leskovac, A., Čolović, M., Bondžić, A.,& Petrović, S.. (2021). N-Acetylcysteine as Regulator of the Cellular Homeostasis. in 7th Workshop Specific Methods for Food Safety and Quality, September 22nd, 2021, Belgrade, Serbia, 15th International Conference on Fundamental and Applied Aspects of Physical Chemistry - Physical Chemistry
Belgrade : Vinča Institute of Nuclear Sciences., 192-195.
https://hdl.handle.net/21.15107/rcub_vinar_11686

Leskovac A, Čolović M, Bondžić A, Petrović S. N-Acetylcysteine as Regulator of the Cellular Homeostasis. in 7th Workshop Specific Methods for Food Safety and Quality, September 22nd, 2021, Belgrade, Serbia, 15th International Conference on Fundamental and Applied Aspects of Physical Chemistry - Physical Chemistry. 2021;:192-195.
https://hdl.handle.net/21.15107/rcub_vinar_11686 .

Leskovac, Andreja, Čolović, Mirjana, Bondžić, Aleksandra, Petrović, Sandra, "N-Acetylcysteine as Regulator of the Cellular Homeostasis" in 7th Workshop Specific Methods for Food Safety and Quality, September 22nd, 2021, Belgrade, Serbia, 15th International Conference on Fundamental and Applied Aspects of Physical Chemistry - Physical Chemistry (2021):192-195,
https://hdl.handle.net/21.15107/rcub_vinar_11686 .

TY  - JOUR
AU  - Stamenović, Una
AU  - Davidović, Slađana
AU  - Petrović, Sandra
AU  - Leskovac, Andreja
AU  - Stoiljković, Milovan
AU  - Vodnik, Vesna
PY  - 2021
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/9874
AB  - Two silver–polyaniline/polyvinylpyrrolidone (Ag–PANI/PVP) nanocomposites were prepared using in situ integration of silver nanoparticles (AgNPs) during oxidative aniline polymerization, accelerated by the presence of PVP, which as well minimized the risk of particle agglomeration and macroscopic precipitation. Both nanocomposites have similar silver content (∼44 wt% Ag) but different morphological features of AgNPs (spheres/triangles) and polymers (granular/wrinkling pattern). Several spectroscopic, macroscopic, and analytical techniques, microscopy, and surface analysis methods have been used to analyze their physical and chemical properties. Investigation of their antimicrobial potential and possible application as an effective weapon against indicator microbial strains, E. coli, S. aureus, and C. albicans, has shown inhibition of microbial growth by more than 90%, even at low composite concentrations (5 ppm) and short contact time (4 h). A biosafety assessment of Ag–PANI/PVP that comprised testing the genotoxicity and redox modulating activity was performed using human peripheral blood cells as a model system. The obtained results have shown that the investigated Ag–PANI/PVP exhibited significant prooxidant and cytostatic effects (p < 0.05) with no apparent potential to induce DNA damage. Although precautions should be taken to protect human health, the significant antimicrobial efficiency of Ag–PANI/PVP makes it suitable for further studies and applications in non-medical areas, such as wastewater treatment.
T2  - New Journal of Chemistry
T1  - Antimicrobial and biological effects of polyaniline/polyvinylpyrrolidone nanocomposites loaded with silver nanospheres/triangles
VL  - 45
IS  - 28
SP  - 12711
EP  - 12720
DO  - 10.1039/D1NJ02729H
ER  - 

@article{
author = "Stamenović, Una and Davidović, Slađana and Petrović, Sandra and Leskovac, Andreja and Stoiljković, Milovan and Vodnik, Vesna",
year = "2021",
abstract = "Two silver–polyaniline/polyvinylpyrrolidone (Ag–PANI/PVP) nanocomposites were prepared using in situ integration of silver nanoparticles (AgNPs) during oxidative aniline polymerization, accelerated by the presence of PVP, which as well minimized the risk of particle agglomeration and macroscopic precipitation. Both nanocomposites have similar silver content (∼44 wt% Ag) but different morphological features of AgNPs (spheres/triangles) and polymers (granular/wrinkling pattern). Several spectroscopic, macroscopic, and analytical techniques, microscopy, and surface analysis methods have been used to analyze their physical and chemical properties. Investigation of their antimicrobial potential and possible application as an effective weapon against indicator microbial strains, E. coli, S. aureus, and C. albicans, has shown inhibition of microbial growth by more than 90%, even at low composite concentrations (5 ppm) and short contact time (4 h). A biosafety assessment of Ag–PANI/PVP that comprised testing the genotoxicity and redox modulating activity was performed using human peripheral blood cells as a model system. The obtained results have shown that the investigated Ag–PANI/PVP exhibited significant prooxidant and cytostatic effects (p < 0.05) with no apparent potential to induce DNA damage. Although precautions should be taken to protect human health, the significant antimicrobial efficiency of Ag–PANI/PVP makes it suitable for further studies and applications in non-medical areas, such as wastewater treatment.",
journal = "New Journal of Chemistry",
title = "Antimicrobial and biological effects of polyaniline/polyvinylpyrrolidone nanocomposites loaded with silver nanospheres/triangles",
volume = "45",
number = "28",
pages = "12711-12720",
doi = "10.1039/D1NJ02729H"
}

Stamenović, U., Davidović, S., Petrović, S., Leskovac, A., Stoiljković, M.,& Vodnik, V.. (2021). Antimicrobial and biological effects of polyaniline/polyvinylpyrrolidone nanocomposites loaded with silver nanospheres/triangles. in New Journal of Chemistry, 45(28), 12711-12720.
https://doi.org/10.1039/D1NJ02729H

Stamenović U, Davidović S, Petrović S, Leskovac A, Stoiljković M, Vodnik V. Antimicrobial and biological effects of polyaniline/polyvinylpyrrolidone nanocomposites loaded with silver nanospheres/triangles. in New Journal of Chemistry. 2021;45(28):12711-12720.
doi:10.1039/D1NJ02729H .

Stamenović, Una, Davidović, Slađana, Petrović, Sandra, Leskovac, Andreja, Stoiljković, Milovan, Vodnik, Vesna, "Antimicrobial and biological effects of polyaniline/polyvinylpyrrolidone nanocomposites loaded with silver nanospheres/triangles" in New Journal of Chemistry, 45, no. 28 (2021):12711-12720,
https://doi.org/10.1039/D1NJ02729H . .

TY  - JOUR
AU  - Ivković, Ivana
AU  - Bukvički, Danka
AU  - Novaković, Miroslav M.
AU  - Majstorović, Ivana
AU  - Leskovac, Andreja
AU  - Petrović, Sandra
AU  - Veljić, Milan
PY  - 2021
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10051
AB  - Liverworts are characterized by a high content of bioactive compounds reported to show antimicrobial, anticancer, and antioxidant properties. In this study, the biological effects of the methanol extract of the liverwort Pellia endiviifolia and its constituents, bis-bibenzyls perrottetin E, 10′-hydroxyperrottetin E, and 10,10′-dihydroxyperrottetin E, were investigated using human peripheral blood cells as a model system. The assessment of the investigated compounds comprised testing their genotoxicity, apoptotic potential, and redox modulating activities. The genotoxicity testing indicated that medium (25 µM) and high concentrations (100 µM) of the investigated compounds displayed genotoxic and antiproliferative effects in human lymphocytes as revealed by significant, concentration-dependent enhancement of the micronuclei incidence and decrease in the cytokinesis-block proliferation index compared to the control (P <.001). Analysis of leukocyte apoptosis showed a substantial potential of all investigated compounds to induce apoptosis, which was not concentration-dependent. The P endiviifolia extract and perrottetin E demonstrated considerable pro-apoptotic potential, even at the lowest concentration (1 µM) applied. Evaluation of the redox modulating effects, which comprised measuring erythrocyte catalase activity and the lymphocyte malondialdehyde level, showed that the investigated compounds did not induce oxidative stress in human peripheral blood cells (P >.05). The observed genotoxic, antiproliferative, and proapoptotic effects of the investigated compounds make them suitable for further comprehensive studies related to their possible applications as anticancer agents.
T2  - Natural Product Communications
T1  - Assessment of the Biological Effects of Pellia endiviifolia and its Constituents in Vitro
VL  - 16
IS  - 11
SP  - 1
DO  - 10.1177/1934578X211056422
ER  - 

@article{
author = "Ivković, Ivana and Bukvički, Danka and Novaković, Miroslav M. and Majstorović, Ivana and Leskovac, Andreja and Petrović, Sandra and Veljić, Milan",
year = "2021",
abstract = "Liverworts are characterized by a high content of bioactive compounds reported to show antimicrobial, anticancer, and antioxidant properties. In this study, the biological effects of the methanol extract of the liverwort Pellia endiviifolia and its constituents, bis-bibenzyls perrottetin E, 10′-hydroxyperrottetin E, and 10,10′-dihydroxyperrottetin E, were investigated using human peripheral blood cells as a model system. The assessment of the investigated compounds comprised testing their genotoxicity, apoptotic potential, and redox modulating activities. The genotoxicity testing indicated that medium (25 µM) and high concentrations (100 µM) of the investigated compounds displayed genotoxic and antiproliferative effects in human lymphocytes as revealed by significant, concentration-dependent enhancement of the micronuclei incidence and decrease in the cytokinesis-block proliferation index compared to the control (P <.001). Analysis of leukocyte apoptosis showed a substantial potential of all investigated compounds to induce apoptosis, which was not concentration-dependent. The P endiviifolia extract and perrottetin E demonstrated considerable pro-apoptotic potential, even at the lowest concentration (1 µM) applied. Evaluation of the redox modulating effects, which comprised measuring erythrocyte catalase activity and the lymphocyte malondialdehyde level, showed that the investigated compounds did not induce oxidative stress in human peripheral blood cells (P >.05). The observed genotoxic, antiproliferative, and proapoptotic effects of the investigated compounds make them suitable for further comprehensive studies related to their possible applications as anticancer agents.",
journal = "Natural Product Communications",
title = "Assessment of the Biological Effects of Pellia endiviifolia and its Constituents in Vitro",
volume = "16",
number = "11",
pages = "1",
doi = "10.1177/1934578X211056422"
}

Ivković, I., Bukvički, D., Novaković, M. M., Majstorović, I., Leskovac, A., Petrović, S.,& Veljić, M.. (2021). Assessment of the Biological Effects of Pellia endiviifolia and its Constituents in Vitro. in Natural Product Communications, 16(11), 1.
https://doi.org/10.1177/1934578X211056422

Ivković I, Bukvički D, Novaković MM, Majstorović I, Leskovac A, Petrović S, Veljić M. Assessment of the Biological Effects of Pellia endiviifolia and its Constituents in Vitro. in Natural Product Communications. 2021;16(11):1.
doi:10.1177/1934578X211056422 .

Ivković, Ivana, Bukvički, Danka, Novaković, Miroslav M., Majstorović, Ivana, Leskovac, Andreja, Petrović, Sandra, Veljić, Milan, "Assessment of the Biological Effects of Pellia endiviifolia and its Constituents in Vitro" in Natural Product Communications, 16, no. 11 (2021):1,
https://doi.org/10.1177/1934578X211056422 . .

TY  - CONF
AU  - Leskovac, Andreja
AU  - Petrović, Sandra
PY  - 2021
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/11581
PB  - Belgrade : Serbian Association for Cancer Research (SDIR)
C3  - SDIR-5 : 5th Congress of the Serbian Association for Cancer Research with international participation "Translational Potential of Cancer Research in Serbia" : Abstract Book
T1  - Ruthenium (II) complexes as promising candidates for cancer therapy
SP  - 74
EP  - 74
UR  - https://hdl.handle.net/21.15107/rcub_vinar_11581
ER  - 

@conference{
author = "Leskovac, Andreja and Petrović, Sandra",
year = "2021",
publisher = "Belgrade : Serbian Association for Cancer Research (SDIR)",
journal = "SDIR-5 : 5th Congress of the Serbian Association for Cancer Research with international participation "Translational Potential of Cancer Research in Serbia" : Abstract Book",
title = "Ruthenium (II) complexes as promising candidates for cancer therapy",
pages = "74-74",
url = "https://hdl.handle.net/21.15107/rcub_vinar_11581"
}

Leskovac, A.,& Petrović, S.. (2021). Ruthenium (II) complexes as promising candidates for cancer therapy. in SDIR-5 : 5th Congress of the Serbian Association for Cancer Research with international participation "Translational Potential of Cancer Research in Serbia" : Abstract Book
Belgrade : Serbian Association for Cancer Research (SDIR)., 74-74.
https://hdl.handle.net/21.15107/rcub_vinar_11581

Leskovac A, Petrović S. Ruthenium (II) complexes as promising candidates for cancer therapy. in SDIR-5 : 5th Congress of the Serbian Association for Cancer Research with international participation "Translational Potential of Cancer Research in Serbia" : Abstract Book. 2021;:74-74.
https://hdl.handle.net/21.15107/rcub_vinar_11581 .

Leskovac, Andreja, Petrović, Sandra, "Ruthenium (II) complexes as promising candidates for cancer therapy" in SDIR-5 : 5th Congress of the Serbian Association for Cancer Research with international participation "Translational Potential of Cancer Research in Serbia" : Abstract Book (2021):74-74,
https://hdl.handle.net/21.15107/rcub_vinar_11581 .

TY  - CONF
AU  - Petrović, Sandra
AU  - Bondžić, Aleksandra
AU  - Nastasijević, Branislav
AU  - Leskovac, Andreja
PY  - 2021
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/11687
PB  - Belgrade : Vinča Institute of Nuclear Sciences
C3  - 7th Workshop Specific Methods for Food Safety and Quality, September 22nd, 2021, Belgrade, Serbia, 15th International Conference on Fundamental and Applied Aspects of Physical Chemistry - Physical Chemistry
T1  - Genotoxicity Testing of Acacia Honeys of Different Geographical Origin
SP  - 127
EP  - 130
UR  - https://hdl.handle.net/21.15107/rcub_vinar_11687
ER  - 

@conference{
author = "Petrović, Sandra and Bondžić, Aleksandra and Nastasijević, Branislav and Leskovac, Andreja",
year = "2021",
publisher = "Belgrade : Vinča Institute of Nuclear Sciences",
journal = "7th Workshop Specific Methods for Food Safety and Quality, September 22nd, 2021, Belgrade, Serbia, 15th International Conference on Fundamental and Applied Aspects of Physical Chemistry - Physical Chemistry",
title = "Genotoxicity Testing of Acacia Honeys of Different Geographical Origin",
pages = "127-130",
url = "https://hdl.handle.net/21.15107/rcub_vinar_11687"
}

Petrović, S., Bondžić, A., Nastasijević, B.,& Leskovac, A.. (2021). Genotoxicity Testing of Acacia Honeys of Different Geographical Origin. in 7th Workshop Specific Methods for Food Safety and Quality, September 22nd, 2021, Belgrade, Serbia, 15th International Conference on Fundamental and Applied Aspects of Physical Chemistry - Physical Chemistry
Belgrade : Vinča Institute of Nuclear Sciences., 127-130.
https://hdl.handle.net/21.15107/rcub_vinar_11687

Petrović S, Bondžić A, Nastasijević B, Leskovac A. Genotoxicity Testing of Acacia Honeys of Different Geographical Origin. in 7th Workshop Specific Methods for Food Safety and Quality, September 22nd, 2021, Belgrade, Serbia, 15th International Conference on Fundamental and Applied Aspects of Physical Chemistry - Physical Chemistry. 2021;:127-130.
https://hdl.handle.net/21.15107/rcub_vinar_11687 .

Petrović, Sandra, Bondžić, Aleksandra, Nastasijević, Branislav, Leskovac, Andreja, "Genotoxicity Testing of Acacia Honeys of Different Geographical Origin" in 7th Workshop Specific Methods for Food Safety and Quality, September 22nd, 2021, Belgrade, Serbia, 15th International Conference on Fundamental and Applied Aspects of Physical Chemistry - Physical Chemistry (2021):127-130,
https://hdl.handle.net/21.15107/rcub_vinar_11687 .

TY  - CONF
AU  - Bondžić, Aleksandra
AU  - Jovanović, Dunja
AU  - Leskovac, Andreja
AU  - Džambaski, Zdravko
AU  - Bondžić, Bojan
PY  - 2021
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/11683
AB  - In this study, the kinetics of bovine serum albumin (BSA) adsorption from aqueous solutions on the
methionine stabilized silver nanoparticles (AgNPs) was investigated. The influence of the parameters
such as contact time and BSA initial concentration on the adsorption capacity of AgNPs were tested.
By increasing the contact time up to 30 min, the percentage of adsorbed BSA was increased. After
this time, no changes were observed, indicating that the equilibrium state was reached. Investigation
of the initial concentration-effect showed that the percentage of BSA adsorption increased with
increasing BSA concentration until the available binding sites were saturated. After that, more BSA
molecules were left unadsorbed. To elucidate the adsorption kinetic, pseudo-first-order, pseudosecond-order, and intraparticle diffusion kinetic models were applied. The pseudo-second-order well
described the adsorption process and intraparticle diffusion model rate laws, and the intraparticle
diffusion is the sole rate-controlling step.
PB  - The Society of Physical Chemists of Serbia
C3  - 15th International Conference on Fundamental and Applied Aspects of Physical Chemistry - Physical Chemistry 2021 : proceedings, Volume I, September 20-24
T1  - Kinetics of adsorption of the bovine serum albumin on the silver nanoparticles
SP  - 332
EP  - 335
UR  - https://hdl.handle.net/21.15107/rcub_vinar_11683
ER  - 

@conference{
author = "Bondžić, Aleksandra and Jovanović, Dunja and Leskovac, Andreja and Džambaski, Zdravko and Bondžić, Bojan",
year = "2021",
abstract = "In this study, the kinetics of bovine serum albumin (BSA) adsorption from aqueous solutions on the
methionine stabilized silver nanoparticles (AgNPs) was investigated. The influence of the parameters
such as contact time and BSA initial concentration on the adsorption capacity of AgNPs were tested.
By increasing the contact time up to 30 min, the percentage of adsorbed BSA was increased. After
this time, no changes were observed, indicating that the equilibrium state was reached. Investigation
of the initial concentration-effect showed that the percentage of BSA adsorption increased with
increasing BSA concentration until the available binding sites were saturated. After that, more BSA
molecules were left unadsorbed. To elucidate the adsorption kinetic, pseudo-first-order, pseudosecond-order, and intraparticle diffusion kinetic models were applied. The pseudo-second-order well
described the adsorption process and intraparticle diffusion model rate laws, and the intraparticle
diffusion is the sole rate-controlling step.",
publisher = "The Society of Physical Chemists of Serbia",
journal = "15th International Conference on Fundamental and Applied Aspects of Physical Chemistry - Physical Chemistry 2021 : proceedings, Volume I, September 20-24",
title = "Kinetics of adsorption of the bovine serum albumin on the silver nanoparticles",
pages = "332-335",
url = "https://hdl.handle.net/21.15107/rcub_vinar_11683"
}

Bondžić, A., Jovanović, D., Leskovac, A., Džambaski, Z.,& Bondžić, B.. (2021). Kinetics of adsorption of the bovine serum albumin on the silver nanoparticles. in 15th International Conference on Fundamental and Applied Aspects of Physical Chemistry - Physical Chemistry 2021 : proceedings, Volume I, September 20-24
The Society of Physical Chemists of Serbia., 332-335.
https://hdl.handle.net/21.15107/rcub_vinar_11683

Bondžić A, Jovanović D, Leskovac A, Džambaski Z, Bondžić B. Kinetics of adsorption of the bovine serum albumin on the silver nanoparticles. in 15th International Conference on Fundamental and Applied Aspects of Physical Chemistry - Physical Chemistry 2021 : proceedings, Volume I, September 20-24. 2021;:332-335.
https://hdl.handle.net/21.15107/rcub_vinar_11683 .

Bondžić, Aleksandra, Jovanović, Dunja, Leskovac, Andreja, Džambaski, Zdravko, Bondžić, Bojan, "Kinetics of adsorption of the bovine serum albumin on the silver nanoparticles" in 15th International Conference on Fundamental and Applied Aspects of Physical Chemistry - Physical Chemistry 2021 : proceedings, Volume I, September 20-24 (2021):332-335,
https://hdl.handle.net/21.15107/rcub_vinar_11683 .

TY  - JOUR
AU  - Laban, Bojana B.
AU  - Ralević, Uroš
AU  - Petrović, Sandra
AU  - Leskovac, Andreja
AU  - Vasić Anićijević, Dragana D.
AU  - Marković, Mirjana
AU  - Vasić, Vesna M.
PY  - 2020
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/8673
AB  - The simple green method for synthesis of stable L-Methionine (L-Met) capped silver (Ag@LM NPs) and gold (Au@LM NPs) nanoparticles (NPs) without adding any additional reduction agent or stabilizer was developed. Colloidal dispersions were characterized by UV–Vis spectrophotometry. The size and spherical shape of NPs were evaluated by transmission electron microscopy. Their surface covering was confirmed by atomic force microscopy, Fourier transform infrared spectroscopy, dynamic light scattering, and zeta potential measurements. Density functional theory calculations pointed that the preferential adsorption mode of L-Met on both Ag and Au surfaces was a vertical binding geometry via –NH2 group, while horizontal binding mode via [sbnd]S[sbnd] and –NH2 groups is also possible. The genotoxicity (evaluated by the micronucleus assay) of NPs, as well as their effects on some oxidative stress parameters (catalase activity, malondialdehyde level), were assessed in vitro using human peripheral blood cells as a model system. The influence of NPs on the morphology of lymphocyte cells studied using atomic force microscopy revealed that the membrane of cells remained unaffected after the treatment with NPs. When considering the effects of NPs on catalase activity and malondialdehyde level, neither particle type promoted oxidative stress. However, the treatment of lymphocytes with Ag@LM NPs induced a concentration-dependent enhancement of the micronuclei incidence and suppression of the cell proliferation while Au@LM NPs promoted cell proliferation, with no significant effects on micronuclei formation. The Ag@LM NPs were more prone to induce DNA damage than Au@LM NPs, which makes the latter type more suitable for further studies in nano-medicine. © 2019
T2  - Journal of Inorganic Biochemistry
T1  - Green synthesis and characterization of nontoxic L-methionine capped silver and gold nanoparticles
VL  - 204
SP  - 110958
DO  - 10.1016/j.jinorgbio.2019.110958
ER  - 

@article{
author = "Laban, Bojana B. and Ralević, Uroš and Petrović, Sandra and Leskovac, Andreja and Vasić Anićijević, Dragana D. and Marković, Mirjana and Vasić, Vesna M.",
year = "2020",
abstract = "The simple green method for synthesis of stable L-Methionine (L-Met) capped silver (Ag@LM NPs) and gold (Au@LM NPs) nanoparticles (NPs) without adding any additional reduction agent or stabilizer was developed. Colloidal dispersions were characterized by UV–Vis spectrophotometry. The size and spherical shape of NPs were evaluated by transmission electron microscopy. Their surface covering was confirmed by atomic force microscopy, Fourier transform infrared spectroscopy, dynamic light scattering, and zeta potential measurements. Density functional theory calculations pointed that the preferential adsorption mode of L-Met on both Ag and Au surfaces was a vertical binding geometry via –NH2 group, while horizontal binding mode via [sbnd]S[sbnd] and –NH2 groups is also possible. The genotoxicity (evaluated by the micronucleus assay) of NPs, as well as their effects on some oxidative stress parameters (catalase activity, malondialdehyde level), were assessed in vitro using human peripheral blood cells as a model system. The influence of NPs on the morphology of lymphocyte cells studied using atomic force microscopy revealed that the membrane of cells remained unaffected after the treatment with NPs. When considering the effects of NPs on catalase activity and malondialdehyde level, neither particle type promoted oxidative stress. However, the treatment of lymphocytes with Ag@LM NPs induced a concentration-dependent enhancement of the micronuclei incidence and suppression of the cell proliferation while Au@LM NPs promoted cell proliferation, with no significant effects on micronuclei formation. The Ag@LM NPs were more prone to induce DNA damage than Au@LM NPs, which makes the latter type more suitable for further studies in nano-medicine. © 2019",
journal = "Journal of Inorganic Biochemistry",
title = "Green synthesis and characterization of nontoxic L-methionine capped silver and gold nanoparticles",
volume = "204",
pages = "110958",
doi = "10.1016/j.jinorgbio.2019.110958"
}

Laban, B. B., Ralević, U., Petrović, S., Leskovac, A., Vasić Anićijević, D. D., Marković, M.,& Vasić, V. M.. (2020). Green synthesis and characterization of nontoxic L-methionine capped silver and gold nanoparticles. in Journal of Inorganic Biochemistry, 204, 110958.
https://doi.org/10.1016/j.jinorgbio.2019.110958

Laban BB, Ralević U, Petrović S, Leskovac A, Vasić Anićijević DD, Marković M, Vasić VM. Green synthesis and characterization of nontoxic L-methionine capped silver and gold nanoparticles. in Journal of Inorganic Biochemistry. 2020;204:110958.
doi:10.1016/j.jinorgbio.2019.110958 .

Laban, Bojana B., Ralević, Uroš, Petrović, Sandra, Leskovac, Andreja, Vasić Anićijević, Dragana D., Marković, Mirjana, Vasić, Vesna M., "Green synthesis and characterization of nontoxic L-methionine capped silver and gold nanoparticles" in Journal of Inorganic Biochemistry, 204 (2020):110958,
https://doi.org/10.1016/j.jinorgbio.2019.110958 . .

TY  - JOUR
AU  - Bondžić, Aleksandra M.
AU  - Lazarević-Pašti, Tamara
AU  - Leskovac, Andreja
AU  - Petrović, Sandra
AU  - Čolović, Mirjana B.
AU  - Parac-Vogt, Tatjana N.
AU  - Janjić, Goran V.
PY  - 2020
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/9028
AB  - Acetylcholinesterase (AChE) inhibitors are important in the treatment of neurodegenerative diseases. Two inhibitors,12-tungstosilicic acid (WSiA) and 12-tungstophosphoric acid (WPA), which have polyoxometalate(POM) type structure, have been shown to inhibit AChE activity in nM concentration. Circular dichroism andtryptophan fluorescence spectroscopy demonstrated that the AChE inhibition was not accompanied by significantchanges in the secondary structure of the enzyme. The molecular docking approach has revealed a newallosteric binding site, termed β-allosteric site (β-AS), which is considered responsible for the inhibition of AChEby POMs. To the best of our knowledge, this is the first study reporting a new allosteric site that is consideredresponsible for AChE inhibition by voluminous and negatively charged molecules such as POMs. The selectedPOMs were further subjected to genotoxicity testing using human peripheral blood cells as a model system. Itwas shown that WSiA and WPA induced a mild cytostatic but not genotoxic effects in human lymphocytes, whichindicates their potential to be used as medicinal drugs. The identification of non-toxic compounds capable ofbinding to an allosteric site that so far has not been considered responsible for enzyme inhibition could befundamental for the development of new drug design strategies and the discovery of more efficient AChEmodulators.
T2  - European Journal of Pharmaceutical Sciences
T1  - A new acetylcholinesterase allosteric site responsible for binding voluminous negatively charged molecules – the role in the mechanism of AChE inhibition
VL  - 151
SP  - 105376
DO  - 10.1016/j.ejps.2020.105376
ER  - 

@article{
author = "Bondžić, Aleksandra M. and Lazarević-Pašti, Tamara and Leskovac, Andreja and Petrović, Sandra and Čolović, Mirjana B. and Parac-Vogt, Tatjana N. and Janjić, Goran V.",
year = "2020",
abstract = "Acetylcholinesterase (AChE) inhibitors are important in the treatment of neurodegenerative diseases. Two inhibitors,12-tungstosilicic acid (WSiA) and 12-tungstophosphoric acid (WPA), which have polyoxometalate(POM) type structure, have been shown to inhibit AChE activity in nM concentration. Circular dichroism andtryptophan fluorescence spectroscopy demonstrated that the AChE inhibition was not accompanied by significantchanges in the secondary structure of the enzyme. The molecular docking approach has revealed a newallosteric binding site, termed β-allosteric site (β-AS), which is considered responsible for the inhibition of AChEby POMs. To the best of our knowledge, this is the first study reporting a new allosteric site that is consideredresponsible for AChE inhibition by voluminous and negatively charged molecules such as POMs. The selectedPOMs were further subjected to genotoxicity testing using human peripheral blood cells as a model system. Itwas shown that WSiA and WPA induced a mild cytostatic but not genotoxic effects in human lymphocytes, whichindicates their potential to be used as medicinal drugs. The identification of non-toxic compounds capable ofbinding to an allosteric site that so far has not been considered responsible for enzyme inhibition could befundamental for the development of new drug design strategies and the discovery of more efficient AChEmodulators.",
journal = "European Journal of Pharmaceutical Sciences",
title = "A new acetylcholinesterase allosteric site responsible for binding voluminous negatively charged molecules – the role in the mechanism of AChE inhibition",
volume = "151",
pages = "105376",
doi = "10.1016/j.ejps.2020.105376"
}

Bondžić, A. M., Lazarević-Pašti, T., Leskovac, A., Petrović, S., Čolović, M. B., Parac-Vogt, T. N.,& Janjić, G. V.. (2020). A new acetylcholinesterase allosteric site responsible for binding voluminous negatively charged molecules – the role in the mechanism of AChE inhibition. in European Journal of Pharmaceutical Sciences, 151, 105376.
https://doi.org/10.1016/j.ejps.2020.105376

Bondžić AM, Lazarević-Pašti T, Leskovac A, Petrović S, Čolović MB, Parac-Vogt TN, Janjić GV. A new acetylcholinesterase allosteric site responsible for binding voluminous negatively charged molecules – the role in the mechanism of AChE inhibition. in European Journal of Pharmaceutical Sciences. 2020;151:105376.
doi:10.1016/j.ejps.2020.105376 .

Bondžić, Aleksandra M., Lazarević-Pašti, Tamara, Leskovac, Andreja, Petrović, Sandra, Čolović, Mirjana B., Parac-Vogt, Tatjana N., Janjić, Goran V., "A new acetylcholinesterase allosteric site responsible for binding voluminous negatively charged molecules – the role in the mechanism of AChE inhibition" in European Journal of Pharmaceutical Sciences, 151 (2020):105376,
https://doi.org/10.1016/j.ejps.2020.105376 . .

TY  - JOUR
AU  - Savić, Jasmina
AU  - Petrović, Sandra
AU  - Leskovac, Andreja
AU  - Lazarević-Pašti, Tamara
AU  - Nastasijević, Branislav J.
AU  - Tanović, Brankica B.
AU  - Gašić, Slavica M.
AU  - Vasić, Vesna M.
PY  - 2019
UR  - https://linkinghub.elsevier.com/retrieve/pii/S0308814618313670
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/7821
AB  - UV-C irradiation is widely used in the food industry. However, the health effects from dietary exposure to the irradiated pesticide residues retained in foodstuffs are underestimated. In this study, technical chlorpyrifos (TCPF) and its oil in water (EW) and emulsifiable concentrate (EC) formulations were irradiated by UV-C, and their photodegradation products were subjected to toxicity assessment, including determination of acetylcholinesterase (AChE) activity, genotoxicity and oxidative stress using human blood cells as a model system. Toxicity studies were performed using the chlorpyrifos concentrations in the range of those proposed as the maximum residue levels in plant commodities. TCPF, EW and EC photodegradation products induced DNA damage and oxidative stress, and their genotoxicity did not decrease as a function of irradiation time. Irradiated TCPF and EC are more potent AChE inhibitors than irradiated EW. Accordingly, the application of UV-C irradiation must be considered when processing the plants previously treated with chlorpyrifos formulations. © 2018 Elsevier Ltd
T2  - Food Chemistry
T1  - UV-C light irradiation enhances toxic effects of chlorpyrifos and its formulations
VL  - 271
SP  - 469
EP  - 478
DO  - 10.1016/j.foodchem.2018.07.207
ER  - 

@article{
author = "Savić, Jasmina and Petrović, Sandra and Leskovac, Andreja and Lazarević-Pašti, Tamara and Nastasijević, Branislav J. and Tanović, Brankica B. and Gašić, Slavica M. and Vasić, Vesna M.",
year = "2019",
abstract = "UV-C irradiation is widely used in the food industry. However, the health effects from dietary exposure to the irradiated pesticide residues retained in foodstuffs are underestimated. In this study, technical chlorpyrifos (TCPF) and its oil in water (EW) and emulsifiable concentrate (EC) formulations were irradiated by UV-C, and their photodegradation products were subjected to toxicity assessment, including determination of acetylcholinesterase (AChE) activity, genotoxicity and oxidative stress using human blood cells as a model system. Toxicity studies were performed using the chlorpyrifos concentrations in the range of those proposed as the maximum residue levels in plant commodities. TCPF, EW and EC photodegradation products induced DNA damage and oxidative stress, and their genotoxicity did not decrease as a function of irradiation time. Irradiated TCPF and EC are more potent AChE inhibitors than irradiated EW. Accordingly, the application of UV-C irradiation must be considered when processing the plants previously treated with chlorpyrifos formulations. © 2018 Elsevier Ltd",
journal = "Food Chemistry",
title = "UV-C light irradiation enhances toxic effects of chlorpyrifos and its formulations",
volume = "271",
pages = "469-478",
doi = "10.1016/j.foodchem.2018.07.207"
}

Savić, J., Petrović, S., Leskovac, A., Lazarević-Pašti, T., Nastasijević, B. J., Tanović, B. B., Gašić, S. M.,& Vasić, V. M.. (2019). UV-C light irradiation enhances toxic effects of chlorpyrifos and its formulations. in Food Chemistry, 271, 469-478.
https://doi.org/10.1016/j.foodchem.2018.07.207

Savić J, Petrović S, Leskovac A, Lazarević-Pašti T, Nastasijević BJ, Tanović BB, Gašić SM, Vasić VM. UV-C light irradiation enhances toxic effects of chlorpyrifos and its formulations. in Food Chemistry. 2019;271:469-478.
doi:10.1016/j.foodchem.2018.07.207 .

Savić, Jasmina, Petrović, Sandra, Leskovac, Andreja, Lazarević-Pašti, Tamara, Nastasijević, Branislav J., Tanović, Brankica B., Gašić, Slavica M., Vasić, Vesna M., "UV-C light irradiation enhances toxic effects of chlorpyrifos and its formulations" in Food Chemistry, 271 (2019):469-478,
https://doi.org/10.1016/j.foodchem.2018.07.207 . .

TY  - DATA
AU  - Savić, Jasmina
AU  - Petrović, Sandra
AU  - Leskovac, Andreja
AU  - Lazarević-Pašti, Tamara
AU  - Nastasijević, Branislav J.
AU  - Tanović, Brankica B.
AU  - Gašić, Slavica M.
AU  - Vasić, Vesna M.
PY  - 2019
UR  - https://linkinghub.elsevier.com/retrieve/pii/S0308814618313670
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/7831
AB  - Supplementary data 1: Table 1S. The chromatographic gradient profile; Table 2S. CPF concentration decrease (corresponding initial CPF concentration decrease was set as 0%) for all three forms of CPF depending on irradiation time; Table 3S. CPF and CPO concentrations determined chromatographically for TCPF, EW and EC formulations, as the function of irradiation time; % of CPO comparing to initial CPF concentration in all three forms of CPF; 
Supplementary data 2: Material safety data sheet according to 1907/2006/EC, Article 31/version 1; 
Supplementary data 3: Material safety data sheet according to 1907/2006/EC, Article 31/version 4
T2  - Food Chemistry
T1  - Supplementary data: UV-C light irradiation enhances toxic effects of chlorpyrifos and its formulations
VL  - 271
SP  - 469
EP  - 478
DO  - 10.1016/j.foodchem.2018.07.207
ER  - 

@misc{
author = "Savić, Jasmina and Petrović, Sandra and Leskovac, Andreja and Lazarević-Pašti, Tamara and Nastasijević, Branislav J. and Tanović, Brankica B. and Gašić, Slavica M. and Vasić, Vesna M.",
year = "2019",
abstract = "Supplementary data 1: Table 1S. The chromatographic gradient profile; Table 2S. CPF concentration decrease (corresponding initial CPF concentration decrease was set as 0%) for all three forms of CPF depending on irradiation time; Table 3S. CPF and CPO concentrations determined chromatographically for TCPF, EW and EC formulations, as the function of irradiation time; % of CPO comparing to initial CPF concentration in all three forms of CPF; 
Supplementary data 2: Material safety data sheet according to 1907/2006/EC, Article 31/version 1; 
Supplementary data 3: Material safety data sheet according to 1907/2006/EC, Article 31/version 4",
journal = "Food Chemistry",
title = "Supplementary data: UV-C light irradiation enhances toxic effects of chlorpyrifos and its formulations",
volume = "271",
pages = "469-478",
doi = "10.1016/j.foodchem.2018.07.207"
}

Savić, J., Petrović, S., Leskovac, A., Lazarević-Pašti, T., Nastasijević, B. J., Tanović, B. B., Gašić, S. M.,& Vasić, V. M.. (2019). Supplementary data: UV-C light irradiation enhances toxic effects of chlorpyrifos and its formulations. in Food Chemistry, 271, 469-478.
https://doi.org/10.1016/j.foodchem.2018.07.207

Savić J, Petrović S, Leskovac A, Lazarević-Pašti T, Nastasijević BJ, Tanović BB, Gašić SM, Vasić VM. Supplementary data: UV-C light irradiation enhances toxic effects of chlorpyrifos and its formulations. in Food Chemistry. 2019;271:469-478.
doi:10.1016/j.foodchem.2018.07.207 .

Savić, Jasmina, Petrović, Sandra, Leskovac, Andreja, Lazarević-Pašti, Tamara, Nastasijević, Branislav J., Tanović, Brankica B., Gašić, Slavica M., Vasić, Vesna M., "Supplementary data: UV-C light irradiation enhances toxic effects of chlorpyrifos and its formulations" in Food Chemistry, 271 (2019):469-478,
https://doi.org/10.1016/j.foodchem.2018.07.207 . .

TY  - JOUR
AU  - Bondžić, Aleksandra M.
AU  - Leskovac, Andreja
AU  - Petrović, Sandra
AU  - Vasić Anićijević, Dragana D.
AU  - Luce, Marco
AU  - Massai, Lara
AU  - Generosi, Amanda
AU  - Paci, Barbara
AU  - Cricenti, Antonio
AU  - Messori, Luigi
AU  - Vasić, Vesna M.
PY  - 2019
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/8747
AB  - Citrate-capped gold nanoparticles (AuNPs) were functionalized with three distinct antitumor gold(III) complexes, e.g., [Au(N,N)(OH)2][PF6], where (N,N)=2,2′-bipyridine; [Au(C,N)(AcO)2], where (C,N)=deprotonated 6-(1,1-dimethylbenzyl)-pyridine; [Au(C,N,N)(OH)][PF6], where (C,N,N)=deprotonated 6-(1,1-dimethylbenzyl)-2,2′-bipyridine, to assess the chance of tracking their subcellular distribution by atomic force microscopy (AFM), and surface enhanced Raman spectroscopy (SERS) techniques. An extensive physicochemical characterization of the formed conjugates was, thus, carried out by applying a variety of methods (density functional theory—DFT, UV/Vis spectrophotometry, AFM, Raman spectroscopy, and SERS). The resulting gold(III) complexes/AuNPs conjugates turned out to be pretty stable. Interestingly, they exhibited a dramatically increased resonance intensity in the Raman spectra induced by AuNPs. For testing the use of the functionalized AuNPs for biosensing, their distribution in the nuclear, cytosolic, and membrane cell fractions obtained from human lymphocytes was investigated by AFM and SERS. The conjugates were detected in the membrane and nuclear cell fractions but not in the cytosol. The AFM method confirmed that conjugates induced changes in the morphology and nanostructure of the membrane and nuclear fractions. The obtained results point out that the conjugates formed between AuNPs and gold(III) complexes may be used as a tool for tracking metallodrug distribution in the different cell fractions.
T2  - International Journal of Molecular Sciences
T1  - Conjugates of Gold Nanoparticles and Antitumor Gold(III) Complexes as a Tool for Their AFM and SERS Detection in Biological Tissue
VL  - 20
IS  - 24
SP  - 6306
DO  - 10.3390/ijms20246306
ER  - 

@article{
author = "Bondžić, Aleksandra M. and Leskovac, Andreja and Petrović, Sandra and Vasić Anićijević, Dragana D. and Luce, Marco and Massai, Lara and Generosi, Amanda and Paci, Barbara and Cricenti, Antonio and Messori, Luigi and Vasić, Vesna M.",
year = "2019",
abstract = "Citrate-capped gold nanoparticles (AuNPs) were functionalized with three distinct antitumor gold(III) complexes, e.g., [Au(N,N)(OH)2][PF6], where (N,N)=2,2′-bipyridine; [Au(C,N)(AcO)2], where (C,N)=deprotonated 6-(1,1-dimethylbenzyl)-pyridine; [Au(C,N,N)(OH)][PF6], where (C,N,N)=deprotonated 6-(1,1-dimethylbenzyl)-2,2′-bipyridine, to assess the chance of tracking their subcellular distribution by atomic force microscopy (AFM), and surface enhanced Raman spectroscopy (SERS) techniques. An extensive physicochemical characterization of the formed conjugates was, thus, carried out by applying a variety of methods (density functional theory—DFT, UV/Vis spectrophotometry, AFM, Raman spectroscopy, and SERS). The resulting gold(III) complexes/AuNPs conjugates turned out to be pretty stable. Interestingly, they exhibited a dramatically increased resonance intensity in the Raman spectra induced by AuNPs. For testing the use of the functionalized AuNPs for biosensing, their distribution in the nuclear, cytosolic, and membrane cell fractions obtained from human lymphocytes was investigated by AFM and SERS. The conjugates were detected in the membrane and nuclear cell fractions but not in the cytosol. The AFM method confirmed that conjugates induced changes in the morphology and nanostructure of the membrane and nuclear fractions. The obtained results point out that the conjugates formed between AuNPs and gold(III) complexes may be used as a tool for tracking metallodrug distribution in the different cell fractions.",
journal = "International Journal of Molecular Sciences",
title = "Conjugates of Gold Nanoparticles and Antitumor Gold(III) Complexes as a Tool for Their AFM and SERS Detection in Biological Tissue",
volume = "20",
number = "24",
pages = "6306",
doi = "10.3390/ijms20246306"
}

Bondžić, A. M., Leskovac, A., Petrović, S., Vasić Anićijević, D. D., Luce, M., Massai, L., Generosi, A., Paci, B., Cricenti, A., Messori, L.,& Vasić, V. M.. (2019). Conjugates of Gold Nanoparticles and Antitumor Gold(III) Complexes as a Tool for Their AFM and SERS Detection in Biological Tissue. in International Journal of Molecular Sciences, 20(24), 6306.
https://doi.org/10.3390/ijms20246306

Bondžić AM, Leskovac A, Petrović S, Vasić Anićijević DD, Luce M, Massai L, Generosi A, Paci B, Cricenti A, Messori L, Vasić VM. Conjugates of Gold Nanoparticles and Antitumor Gold(III) Complexes as a Tool for Their AFM and SERS Detection in Biological Tissue. in International Journal of Molecular Sciences. 2019;20(24):6306.
doi:10.3390/ijms20246306 .

Bondžić, Aleksandra M., Leskovac, Andreja, Petrović, Sandra, Vasić Anićijević, Dragana D., Luce, Marco, Massai, Lara, Generosi, Amanda, Paci, Barbara, Cricenti, Antonio, Messori, Luigi, Vasić, Vesna M., "Conjugates of Gold Nanoparticles and Antitumor Gold(III) Complexes as a Tool for Their AFM and SERS Detection in Biological Tissue" in International Journal of Molecular Sciences, 20, no. 24 (2019):6306,
https://doi.org/10.3390/ijms20246306 . .

TY  - JOUR
AU  - Ongaro, Linda
AU  - Scliar, Marilia O
AU  - Flores, Rodrigo
AU  - Raveane, Alessandro
AU  - Marnetto, Davide
AU  - Sarno, Stefania
AU  - Gnecchi-Ruscone, Guido A
AU  - Alarcón-Riquelme, Marta E
AU  - Patin, Etienne
AU  - Wangkumhang, Pongsakorn
AU  - Hellenthal, Garrett
AU  - Gonzalez-Santos, Miguel
AU  - King, Roy J
AU  - Kouvatsi, Anastasia
AU  - Balanovsky, Oleg
AU  - Balanovska, Elena
AU  - Atramentova, Lubov
AU  - Turdikulova, Shahlo
AU  - Mastana, Sarabjit
AU  - Marjanović, Damir
AU  - Mulahasanović, Lejla
AU  - Leskovac, Andreja
AU  - Lima-Costa, Maria F
AU  - Pereira, Alexandre C
AU  - Barreto, Mauricio L
AU  - Horta, Bernardo L
AU  - Mabunda, Nédio
AU  - May, Celia A
AU  - Moreno-Estrada, Andrés
AU  - Achilli, Alessandro
AU  - Olivieri, Anna
AU  - Semino, Ornella
AU  - Tambets, Kristiina
AU  - Kivisild, Toomas
AU  - Luiselli, Donata
AU  - Torroni, Antonio
AU  - Capelli, Cristian
AU  - Tarazona-Santos, Eduardo
AU  - Metspalu, Mait
AU  - Pagani, Luca
AU  - Montinaro, Francesco
PY  - 2019
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/8654
AB  - The complexity of the admixture dynamics that shaped American populations is unveiled by Ongaro et al., where genetic data for more than 12,000 individuals from the continents are investigated. This study evaluates the dramatic impact of events after the colonial era, revealing a spatial and temporal heterogeneity and mirroring historical records. © 2019 Elsevier Ltd The human genetic diversity of the Americas has been affected by several events of gene flow that have continued since the colonial era and the Atlantic slave trade. Moreover, multiple waves of migration followed by local admixture occurred in the last two centuries, the impact of which has been largely unexplored. Here, we compiled a genome-wide dataset of ∼12,000 individuals from twelve American countries and ∼6,000 individuals from worldwide populations and applied haplotype-based methods to investigate how historical movements from outside the New World affected (1) the genetic structure, (2) the admixture profile, (3) the demographic history, and (4) sex-biased gene-flow dynamics of the Americas. We revealed a high degree of complexity underlying the genetic contribution of European and African populations in North and South America, from both geographic and temporal perspectives, identifying previously unreported sources related to Italy, the Middle East, and to specific regions of Africa. © 2019 Elsevier Ltd
T2  - Current Biology
T1  - The Genomic Impact of European Colonization of the Americas
VL  - 29
IS  - 23
SP  - 3974
EP  - 3986.e4
DO  - 10.1016/j.cub.2019.09.076
ER  - 

@article{
author = "Ongaro, Linda and Scliar, Marilia O and Flores, Rodrigo and Raveane, Alessandro and Marnetto, Davide and Sarno, Stefania and Gnecchi-Ruscone, Guido A and Alarcón-Riquelme, Marta E and Patin, Etienne and Wangkumhang, Pongsakorn and Hellenthal, Garrett and Gonzalez-Santos, Miguel and King, Roy J and Kouvatsi, Anastasia and Balanovsky, Oleg and Balanovska, Elena and Atramentova, Lubov and Turdikulova, Shahlo and Mastana, Sarabjit and Marjanović, Damir and Mulahasanović, Lejla and Leskovac, Andreja and Lima-Costa, Maria F and Pereira, Alexandre C and Barreto, Mauricio L and Horta, Bernardo L and Mabunda, Nédio and May, Celia A and Moreno-Estrada, Andrés and Achilli, Alessandro and Olivieri, Anna and Semino, Ornella and Tambets, Kristiina and Kivisild, Toomas and Luiselli, Donata and Torroni, Antonio and Capelli, Cristian and Tarazona-Santos, Eduardo and Metspalu, Mait and Pagani, Luca and Montinaro, Francesco",
year = "2019",
abstract = "The complexity of the admixture dynamics that shaped American populations is unveiled by Ongaro et al., where genetic data for more than 12,000 individuals from the continents are investigated. This study evaluates the dramatic impact of events after the colonial era, revealing a spatial and temporal heterogeneity and mirroring historical records. © 2019 Elsevier Ltd The human genetic diversity of the Americas has been affected by several events of gene flow that have continued since the colonial era and the Atlantic slave trade. Moreover, multiple waves of migration followed by local admixture occurred in the last two centuries, the impact of which has been largely unexplored. Here, we compiled a genome-wide dataset of ∼12,000 individuals from twelve American countries and ∼6,000 individuals from worldwide populations and applied haplotype-based methods to investigate how historical movements from outside the New World affected (1) the genetic structure, (2) the admixture profile, (3) the demographic history, and (4) sex-biased gene-flow dynamics of the Americas. We revealed a high degree of complexity underlying the genetic contribution of European and African populations in North and South America, from both geographic and temporal perspectives, identifying previously unreported sources related to Italy, the Middle East, and to specific regions of Africa. © 2019 Elsevier Ltd",
journal = "Current Biology",
title = "The Genomic Impact of European Colonization of the Americas",
volume = "29",
number = "23",
pages = "3974-3986.e4",
doi = "10.1016/j.cub.2019.09.076"
}

Ongaro, L., Scliar, M. O., Flores, R., Raveane, A., Marnetto, D., Sarno, S., Gnecchi-Ruscone, G. A., Alarcón-Riquelme, M. E., Patin, E., Wangkumhang, P., Hellenthal, G., Gonzalez-Santos, M., King, R. J., Kouvatsi, A., Balanovsky, O., Balanovska, E., Atramentova, L., Turdikulova, S., Mastana, S., Marjanović, D., Mulahasanović, L., Leskovac, A., Lima-Costa, M. F., Pereira, A. C., Barreto, M. L., Horta, B. L., Mabunda, N., May, C. A., Moreno-Estrada, A., Achilli, A., Olivieri, A., Semino, O., Tambets, K., Kivisild, T., Luiselli, D., Torroni, A., Capelli, C., Tarazona-Santos, E., Metspalu, M., Pagani, L.,& Montinaro, F.. (2019). The Genomic Impact of European Colonization of the Americas. in Current Biology, 29(23), 3974-3986.e4.
https://doi.org/10.1016/j.cub.2019.09.076

Ongaro L, Scliar MO, Flores R, Raveane A, Marnetto D, Sarno S, Gnecchi-Ruscone GA, Alarcón-Riquelme ME, Patin E, Wangkumhang P, Hellenthal G, Gonzalez-Santos M, King RJ, Kouvatsi A, Balanovsky O, Balanovska E, Atramentova L, Turdikulova S, Mastana S, Marjanović D, Mulahasanović L, Leskovac A, Lima-Costa MF, Pereira AC, Barreto ML, Horta BL, Mabunda N, May CA, Moreno-Estrada A, Achilli A, Olivieri A, Semino O, Tambets K, Kivisild T, Luiselli D, Torroni A, Capelli C, Tarazona-Santos E, Metspalu M, Pagani L, Montinaro F. The Genomic Impact of European Colonization of the Americas. in Current Biology. 2019;29(23):3974-3986.e4.
doi:10.1016/j.cub.2019.09.076 .

Ongaro, Linda, Scliar, Marilia O, Flores, Rodrigo, Raveane, Alessandro, Marnetto, Davide, Sarno, Stefania, Gnecchi-Ruscone, Guido A, Alarcón-Riquelme, Marta E, Patin, Etienne, Wangkumhang, Pongsakorn, Hellenthal, Garrett, Gonzalez-Santos, Miguel, King, Roy J, Kouvatsi, Anastasia, Balanovsky, Oleg, Balanovska, Elena, Atramentova, Lubov, Turdikulova, Shahlo, Mastana, Sarabjit, Marjanović, Damir, Mulahasanović, Lejla, Leskovac, Andreja, Lima-Costa, Maria F, Pereira, Alexandre C, Barreto, Mauricio L, Horta, Bernardo L, Mabunda, Nédio, May, Celia A, Moreno-Estrada, Andrés, Achilli, Alessandro, Olivieri, Anna, Semino, Ornella, Tambets, Kristiina, Kivisild, Toomas, Luiselli, Donata, Torroni, Antonio, Capelli, Cristian, Tarazona-Santos, Eduardo, Metspalu, Mait, Pagani, Luca, Montinaro, Francesco, "The Genomic Impact of European Colonization of the Americas" in Current Biology, 29, no. 23 (2019):3974-3986.e4,
https://doi.org/10.1016/j.cub.2019.09.076 . .

TY  - JOUR
AU  - Ongaro, Linda
AU  - Scliar, Marilia O
AU  - Flores, Rodrigo
AU  - Raveane, Alessandro
AU  - Marnetto, Davide
AU  - Sarno, Stefania
AU  - Gnecchi-Ruscone, Guido A
AU  - Alarcón-Riquelme, Marta E
AU  - Patin, Etienne
AU  - Wangkumhang, Pongsakorn
AU  - Hellenthal, Garrett
AU  - Gonzalez-Santos, Miguel
AU  - King, Roy J
AU  - Kouvatsi, Anastasia
AU  - Balanovsky, Oleg
AU  - Balanovska, Elena
AU  - Atramentova, Lubov
AU  - Turdikulova, Shahlo
AU  - Mastana, Sarabjit
AU  - Marjanović, Damir
AU  - Mulahasanović, Lejla
AU  - Leskovac, Andreja
AU  - Lima-Costa, Maria F
AU  - Pereira, Alexandre C
AU  - Barreto, Mauricio L
AU  - Horta, Bernardo L
AU  - Mabunda, Nédio
AU  - May, Celia A
AU  - Moreno-Estrada, Andrés
AU  - Achilli, Alessandro
AU  - Olivieri, Anna
AU  - Semino, Ornella
AU  - Tambets, Kristiina
AU  - Kivisild, Toomas
AU  - Luiselli, Donata
AU  - Torroni, Antonio
AU  - Capelli, Cristian
AU  - Tarazona-Santos, Eduardo
AU  - Metspalu, Mait
AU  - Pagani, Luca
AU  - Montinaro, Francesco
PY  - 2019
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/8662
AB  - The complexity of the admixture dynamics that shaped American populations is unveiled by Ongaro et al., where genetic data for more than 12,000 individuals from the continents are investigated. This study evaluates the dramatic impact of events after the colonial era, revealing a spatial and temporal heterogeneity and mirroring historical records. © 2019 Elsevier Ltd The human genetic diversity of the Americas has been affected by several events of gene flow that have continued since the colonial era and the Atlantic slave trade. Moreover, multiple waves of migration followed by local admixture occurred in the last two centuries, the impact of which has been largely unexplored. Here, we compiled a genome-wide dataset of ∼12,000 individuals from twelve American countries and ∼6,000 individuals from worldwide populations and applied haplotype-based methods to investigate how historical movements from outside the New World affected (1) the genetic structure, (2) the admixture profile, (3) the demographic history, and (4) sex-biased gene-flow dynamics of the Americas. We revealed a high degree of complexity underlying the genetic contribution of European and African populations in North and South America, from both geographic and temporal perspectives, identifying previously unreported sources related to Italy, the Middle East, and to specific regions of Africa. © 2019 Elsevier Ltd
T2  - Current Biology
T1  - The Genomic Impact of European Colonization of the Americas
VL  - 29
IS  - 23
SP  - 3974
EP  - 3986.e4
DO  - 10.1101/676437
ER  - 

@article{
author = "Ongaro, Linda and Scliar, Marilia O and Flores, Rodrigo and Raveane, Alessandro and Marnetto, Davide and Sarno, Stefania and Gnecchi-Ruscone, Guido A and Alarcón-Riquelme, Marta E and Patin, Etienne and Wangkumhang, Pongsakorn and Hellenthal, Garrett and Gonzalez-Santos, Miguel and King, Roy J and Kouvatsi, Anastasia and Balanovsky, Oleg and Balanovska, Elena and Atramentova, Lubov and Turdikulova, Shahlo and Mastana, Sarabjit and Marjanović, Damir and Mulahasanović, Lejla and Leskovac, Andreja and Lima-Costa, Maria F and Pereira, Alexandre C and Barreto, Mauricio L and Horta, Bernardo L and Mabunda, Nédio and May, Celia A and Moreno-Estrada, Andrés and Achilli, Alessandro and Olivieri, Anna and Semino, Ornella and Tambets, Kristiina and Kivisild, Toomas and Luiselli, Donata and Torroni, Antonio and Capelli, Cristian and Tarazona-Santos, Eduardo and Metspalu, Mait and Pagani, Luca and Montinaro, Francesco",
year = "2019",
abstract = "The complexity of the admixture dynamics that shaped American populations is unveiled by Ongaro et al., where genetic data for more than 12,000 individuals from the continents are investigated. This study evaluates the dramatic impact of events after the colonial era, revealing a spatial and temporal heterogeneity and mirroring historical records. © 2019 Elsevier Ltd The human genetic diversity of the Americas has been affected by several events of gene flow that have continued since the colonial era and the Atlantic slave trade. Moreover, multiple waves of migration followed by local admixture occurred in the last two centuries, the impact of which has been largely unexplored. Here, we compiled a genome-wide dataset of ∼12,000 individuals from twelve American countries and ∼6,000 individuals from worldwide populations and applied haplotype-based methods to investigate how historical movements from outside the New World affected (1) the genetic structure, (2) the admixture profile, (3) the demographic history, and (4) sex-biased gene-flow dynamics of the Americas. We revealed a high degree of complexity underlying the genetic contribution of European and African populations in North and South America, from both geographic and temporal perspectives, identifying previously unreported sources related to Italy, the Middle East, and to specific regions of Africa. © 2019 Elsevier Ltd",
journal = "Current Biology",
title = "The Genomic Impact of European Colonization of the Americas",
volume = "29",
number = "23",
pages = "3974-3986.e4",
doi = "10.1101/676437"
}

Ongaro, L., Scliar, M. O., Flores, R., Raveane, A., Marnetto, D., Sarno, S., Gnecchi-Ruscone, G. A., Alarcón-Riquelme, M. E., Patin, E., Wangkumhang, P., Hellenthal, G., Gonzalez-Santos, M., King, R. J., Kouvatsi, A., Balanovsky, O., Balanovska, E., Atramentova, L., Turdikulova, S., Mastana, S., Marjanović, D., Mulahasanović, L., Leskovac, A., Lima-Costa, M. F., Pereira, A. C., Barreto, M. L., Horta, B. L., Mabunda, N., May, C. A., Moreno-Estrada, A., Achilli, A., Olivieri, A., Semino, O., Tambets, K., Kivisild, T., Luiselli, D., Torroni, A., Capelli, C., Tarazona-Santos, E., Metspalu, M., Pagani, L.,& Montinaro, F.. (2019). The Genomic Impact of European Colonization of the Americas. in Current Biology, 29(23), 3974-3986.e4.
https://doi.org/10.1101/676437

Ongaro L, Scliar MO, Flores R, Raveane A, Marnetto D, Sarno S, Gnecchi-Ruscone GA, Alarcón-Riquelme ME, Patin E, Wangkumhang P, Hellenthal G, Gonzalez-Santos M, King RJ, Kouvatsi A, Balanovsky O, Balanovska E, Atramentova L, Turdikulova S, Mastana S, Marjanović D, Mulahasanović L, Leskovac A, Lima-Costa MF, Pereira AC, Barreto ML, Horta BL, Mabunda N, May CA, Moreno-Estrada A, Achilli A, Olivieri A, Semino O, Tambets K, Kivisild T, Luiselli D, Torroni A, Capelli C, Tarazona-Santos E, Metspalu M, Pagani L, Montinaro F. The Genomic Impact of European Colonization of the Americas. in Current Biology. 2019;29(23):3974-3986.e4.
doi:10.1101/676437 .

Ongaro, Linda, Scliar, Marilia O, Flores, Rodrigo, Raveane, Alessandro, Marnetto, Davide, Sarno, Stefania, Gnecchi-Ruscone, Guido A, Alarcón-Riquelme, Marta E, Patin, Etienne, Wangkumhang, Pongsakorn, Hellenthal, Garrett, Gonzalez-Santos, Miguel, King, Roy J, Kouvatsi, Anastasia, Balanovsky, Oleg, Balanovska, Elena, Atramentova, Lubov, Turdikulova, Shahlo, Mastana, Sarabjit, Marjanović, Damir, Mulahasanović, Lejla, Leskovac, Andreja, Lima-Costa, Maria F, Pereira, Alexandre C, Barreto, Mauricio L, Horta, Bernardo L, Mabunda, Nédio, May, Celia A, Moreno-Estrada, Andrés, Achilli, Alessandro, Olivieri, Anna, Semino, Ornella, Tambets, Kristiina, Kivisild, Toomas, Luiselli, Donata, Torroni, Antonio, Capelli, Cristian, Tarazona-Santos, Eduardo, Metspalu, Mait, Pagani, Luca, Montinaro, Francesco, "The Genomic Impact of European Colonization of the Americas" in Current Biology, 29, no. 23 (2019):3974-3986.e4,
https://doi.org/10.1101/676437 . .

TY  - JOUR
AU  - Leskovac, Andreja
AU  - Petrović, Sandra
AU  - Lazarević-Pašti, Tamara
AU  - Krstić, Milena P.
AU  - Vasić, Vesna M.
PY  - 2018
UR  - http://link.springer.com/10.1007/s00775-018-1560-x
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/7765
AB  - In recent years, the search for effective anticancer compounds based on transition metal complexes has been the focus of medical investigations. The synergy between the ruthenium(II) and N-alkylphenothiazine counter-ions (chlorpromazine hydrochloride, thioridazine hydrochloride and trifluoperazine dihydrochloride, respectively) through the formation of three different complexes (1–3) was investigated. We explored whether the selected counter-ions and complexes might affect redox homeostasis and genome integrity of normal human blood cells, and induce an inhibition of Na+/K+-ATPase and AChE at pharmacologically relevant doses. Our results have shown that counter-ions and complexes did not affect the activity of Na+/K+-ATPase, while AChE activity was inhibited in a dose-dependent manner. All investigated compounds disturbed the viability and redox homeostasis of lymphocytes. Complexes 1 and 2 displayed potent cytotoxic and prooxidant action while complex 3 behaved as a weaker genotoxic inducer. Still, the tested complexes appeared to be less genotoxic and more cytostatic than the corresponding counter-ions. The effects of selected complexes were also tested in PC12 and U2OS cancer cells with special attention being given to the ability of phenothiazines to affect dopamine D2 receptors. Using the confocal laser scanning microscopy, we observed that all the complexes reduced cell viability. Although all investigated complexes have been bound to the dopamine receptor D2-eGFP, only complex 3 reduced its surface density and increased its lateral mobility in investigated cell lines. Albeit the role of alternative targets for complex 3 cannot be ruled out, its effects should be further examined as potential treatment strategy against cancer cells that overexpress D2.
T2  - JBIC Journal of Biological Inorganic Chemistry
T1  - Ruthenium(II)-N-alkyl phenothiazine complexes as potential anticancer agents
VL  - 23
IS  - 5
SP  - 689
EP  - 704
DO  - 10.1007/s00775-018-1560-x
ER  - 

@article{
author = "Leskovac, Andreja and Petrović, Sandra and Lazarević-Pašti, Tamara and Krstić, Milena P. and Vasić, Vesna M.",
year = "2018",
abstract = "In recent years, the search for effective anticancer compounds based on transition metal complexes has been the focus of medical investigations. The synergy between the ruthenium(II) and N-alkylphenothiazine counter-ions (chlorpromazine hydrochloride, thioridazine hydrochloride and trifluoperazine dihydrochloride, respectively) through the formation of three different complexes (1–3) was investigated. We explored whether the selected counter-ions and complexes might affect redox homeostasis and genome integrity of normal human blood cells, and induce an inhibition of Na+/K+-ATPase and AChE at pharmacologically relevant doses. Our results have shown that counter-ions and complexes did not affect the activity of Na+/K+-ATPase, while AChE activity was inhibited in a dose-dependent manner. All investigated compounds disturbed the viability and redox homeostasis of lymphocytes. Complexes 1 and 2 displayed potent cytotoxic and prooxidant action while complex 3 behaved as a weaker genotoxic inducer. Still, the tested complexes appeared to be less genotoxic and more cytostatic than the corresponding counter-ions. The effects of selected complexes were also tested in PC12 and U2OS cancer cells with special attention being given to the ability of phenothiazines to affect dopamine D2 receptors. Using the confocal laser scanning microscopy, we observed that all the complexes reduced cell viability. Although all investigated complexes have been bound to the dopamine receptor D2-eGFP, only complex 3 reduced its surface density and increased its lateral mobility in investigated cell lines. Albeit the role of alternative targets for complex 3 cannot be ruled out, its effects should be further examined as potential treatment strategy against cancer cells that overexpress D2.",
journal = "JBIC Journal of Biological Inorganic Chemistry",
title = "Ruthenium(II)-N-alkyl phenothiazine complexes as potential anticancer agents",
volume = "23",
number = "5",
pages = "689-704",
doi = "10.1007/s00775-018-1560-x"
}

Leskovac, A., Petrović, S., Lazarević-Pašti, T., Krstić, M. P.,& Vasić, V. M.. (2018). Ruthenium(II)-N-alkyl phenothiazine complexes as potential anticancer agents. in JBIC Journal of Biological Inorganic Chemistry, 23(5), 689-704.
https://doi.org/10.1007/s00775-018-1560-x

Leskovac A, Petrović S, Lazarević-Pašti T, Krstić MP, Vasić VM. Ruthenium(II)-N-alkyl phenothiazine complexes as potential anticancer agents. in JBIC Journal of Biological Inorganic Chemistry. 2018;23(5):689-704.
doi:10.1007/s00775-018-1560-x .

Leskovac, Andreja, Petrović, Sandra, Lazarević-Pašti, Tamara, Krstić, Milena P., Vasić, Vesna M., "Ruthenium(II)-N-alkyl phenothiazine complexes as potential anticancer agents" in JBIC Journal of Biological Inorganic Chemistry, 23, no. 5 (2018):689-704,
https://doi.org/10.1007/s00775-018-1560-x . .

TY  - JOUR
AU  - Bogdanović, Una
AU  - Dimitrijević, Suzana I.
AU  - Škapin, Srečo Davor
AU  - Popović, Maja
AU  - Rakočević, Zlatko Lj.
AU  - Leskovac, Andreja
AU  - Petrović, Sandra
AU  - Stoiljković, Milovan
AU  - Vodnik, Vesna
PY  - 2018
UR  - https://linkinghub.elsevier.com/retrieve/pii/S0928493117326449
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/7799
AB  - Copper nanoparticles (Cu NPs) have proven to own excellent antimicrobial efficacy, but the problems of easy oxidation and aggregation limit their practical application. Here, nanocomposite based on polyaniline (PANI) and Cu NPs solved this problem and brought additional physicochemical properties that are markedly advantageous for antimicrobial applications. Current work exploits this potential, to examine its time- and concentration-dependent antimicrobial activity, employing E. coli, S. aureus, and C. albicans as a model microbial species. Regarding the presence of polaronic charge carriers in the fibrous polyaniline network, effects of Cu NPs’ size and their partially oxidized surfaces (the data were confirmed by HRTEM, FESEM, XRD, Raman and XPS analysis), as well as rapid copper ions release, Cu-PANI nanocomposite showed efficient bactericidal and fungicidal activities at the concentrations ≤1 ppm, within the incubation time of 2 h. Beside the quantitative analysis, the high levels of cellular disruption for all tested microbes were evidenced by atomic force microscopy. Moreover, the minimum inhibitory and bactericidal concentrations of the Cu-PANI nanocomposite were lower than those reported for other nanocomposites. Using such low concentrations is recognized as a good way to avoid its toxicity toward the environment. For this purpose, Cu-PANI nanocomposite is tested for its genotoxicity and influence on the oxidative status of the human cells in vitro.
T2  - Materials Science and Engineering: C
T1  - Copper-polyaniline nanocomposite: Role of physicochemical properties on the antimicrobial activity and genotoxicity evaluation
VL  - 93
SP  - 49
EP  - 60
DO  - 10.1016/j.msec.2018.07.067
ER  - 

@article{
author = "Bogdanović, Una and Dimitrijević, Suzana I. and Škapin, Srečo Davor and Popović, Maja and Rakočević, Zlatko Lj. and Leskovac, Andreja and Petrović, Sandra and Stoiljković, Milovan and Vodnik, Vesna",
year = "2018",
abstract = "Copper nanoparticles (Cu NPs) have proven to own excellent antimicrobial efficacy, but the problems of easy oxidation and aggregation limit their practical application. Here, nanocomposite based on polyaniline (PANI) and Cu NPs solved this problem and brought additional physicochemical properties that are markedly advantageous for antimicrobial applications. Current work exploits this potential, to examine its time- and concentration-dependent antimicrobial activity, employing E. coli, S. aureus, and C. albicans as a model microbial species. Regarding the presence of polaronic charge carriers in the fibrous polyaniline network, effects of Cu NPs’ size and their partially oxidized surfaces (the data were confirmed by HRTEM, FESEM, XRD, Raman and XPS analysis), as well as rapid copper ions release, Cu-PANI nanocomposite showed efficient bactericidal and fungicidal activities at the concentrations ≤1 ppm, within the incubation time of 2 h. Beside the quantitative analysis, the high levels of cellular disruption for all tested microbes were evidenced by atomic force microscopy. Moreover, the minimum inhibitory and bactericidal concentrations of the Cu-PANI nanocomposite were lower than those reported for other nanocomposites. Using such low concentrations is recognized as a good way to avoid its toxicity toward the environment. For this purpose, Cu-PANI nanocomposite is tested for its genotoxicity and influence on the oxidative status of the human cells in vitro.",
journal = "Materials Science and Engineering: C",
title = "Copper-polyaniline nanocomposite: Role of physicochemical properties on the antimicrobial activity and genotoxicity evaluation",
volume = "93",
pages = "49-60",
doi = "10.1016/j.msec.2018.07.067"
}

Bogdanović, U., Dimitrijević, S. I., Škapin, S. D., Popović, M., Rakočević, Z. Lj., Leskovac, A., Petrović, S., Stoiljković, M.,& Vodnik, V.. (2018). Copper-polyaniline nanocomposite: Role of physicochemical properties on the antimicrobial activity and genotoxicity evaluation. in Materials Science and Engineering: C, 93, 49-60.
https://doi.org/10.1016/j.msec.2018.07.067

Bogdanović U, Dimitrijević SI, Škapin SD, Popović M, Rakočević ZL, Leskovac A, Petrović S, Stoiljković M, Vodnik V. Copper-polyaniline nanocomposite: Role of physicochemical properties on the antimicrobial activity and genotoxicity evaluation. in Materials Science and Engineering: C. 2018;93:49-60.
doi:10.1016/j.msec.2018.07.067 .

Bogdanović, Una, Dimitrijević, Suzana I., Škapin, Srečo Davor, Popović, Maja, Rakočević, Zlatko Lj., Leskovac, Andreja, Petrović, Sandra, Stoiljković, Milovan, Vodnik, Vesna, "Copper-polyaniline nanocomposite: Role of physicochemical properties on the antimicrobial activity and genotoxicity evaluation" in Materials Science and Engineering: C, 93 (2018):49-60,
https://doi.org/10.1016/j.msec.2018.07.067 . .

TY  - CONF
AU  - Bondžić, Aleksandra
AU  - Janjić, G.
AU  - Marković, M.
AU  - Zeković, I.
AU  - Leskovac, Andreja
AU  - Cricentia, A.
AU  - Lucea, M.
AU  - Vasić, Vesna M.
PY  - 2017
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/11713
C3  - 4th Annual Conference on Optical Nanospectroscopy : the book of abstracts; March 28–31, Lisbon, Portugal
T1  - Na,K-ATPase as a target for gold(III) antitumor drugs: application of nanospectroscopy methods for evaluation of reaction mechanism
SP  - 111
EP  - 111
UR  - https://hdl.handle.net/21.15107/rcub_vinar_11713
ER  - 

@conference{
author = "Bondžić, Aleksandra and Janjić, G. and Marković, M. and Zeković, I. and Leskovac, Andreja and Cricentia, A. and Lucea, M. and Vasić, Vesna M.",
year = "2017",
journal = "4th Annual Conference on Optical Nanospectroscopy : the book of abstracts; March 28–31, Lisbon, Portugal",
title = "Na,K-ATPase as a target for gold(III) antitumor drugs: application of nanospectroscopy methods for evaluation of reaction mechanism",
pages = "111-111",
url = "https://hdl.handle.net/21.15107/rcub_vinar_11713"
}

Bondžić, A., Janjić, G., Marković, M., Zeković, I., Leskovac, A., Cricentia, A., Lucea, M.,& Vasić, V. M.. (2017). Na,K-ATPase as a target for gold(III) antitumor drugs: application of nanospectroscopy methods for evaluation of reaction mechanism. in 4th Annual Conference on Optical Nanospectroscopy : the book of abstracts; March 28–31, Lisbon, Portugal, 111-111.
https://hdl.handle.net/21.15107/rcub_vinar_11713

Bondžić A, Janjić G, Marković M, Zeković I, Leskovac A, Cricentia A, Lucea M, Vasić VM. Na,K-ATPase as a target for gold(III) antitumor drugs: application of nanospectroscopy methods for evaluation of reaction mechanism. in 4th Annual Conference on Optical Nanospectroscopy : the book of abstracts; March 28–31, Lisbon, Portugal. 2017;:111-111.
https://hdl.handle.net/21.15107/rcub_vinar_11713 .

Bondžić, Aleksandra, Janjić, G., Marković, M., Zeković, I., Leskovac, Andreja, Cricentia, A., Lucea, M., Vasić, Vesna M., "Na,K-ATPase as a target for gold(III) antitumor drugs: application of nanospectroscopy methods for evaluation of reaction mechanism" in 4th Annual Conference on Optical Nanospectroscopy : the book of abstracts; March 28–31, Lisbon, Portugal (2017):111-111,
https://hdl.handle.net/21.15107/rcub_vinar_11713 .

TY  - JOUR
AU  - Lazarević-Pašti, Tamara
AU  - Leskovac, Andreja
AU  - Momić, Tatjana
AU  - Petrović, Sandra
AU  - Vasić, Vesna M.
PY  - 2017
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/1796
AB  - Background: Acetylcholinesterase (AChE) is involved in the termination of impulse transmission by rapid hydrolysis of the neurotransmitter acetylcholine in numerous cholinergic pathways in the central and peripheral nervous systems. The enzyme inactivation leads to acetylcholine accumulation, hyperstimulation of nicotinic and muscarinic receptors, and disrupted neurotransmission. Hence, acetylcholinesterase inhibitors, interacting with the enzyme as their primary target, are applied as relevant drugs for different neurodegenerative diseases (such as Alzheimers and Parkinsons) as well as toxins. At the same time, there are increasing evidence that in non-neuronal context, AChE is involved in the regulation of cell proliferation, differentiation, apoptosis and cell-cell interaction. An irregular expression of AChE has been found in different types of tumors, suggesting the involvement of AChE in the regulation of tumor development. Having all this in mind, there is a possibility that some AChE inhibitors could be used as anti-cancer agents. Objective: This contribution will discuss a broad range of possible application of different AChE inhibitors as drugs, from well-known anti-Alzheimers disease drugs to their use in cancer treatment in future. Emphasis will be put on various known AChE inhibitors classes, whose application as drugs could be controversy, as well as on newly investigated natural products, which can also modulate AChE activity. Conclusion: It is not clear a patient treated for neurodegenerative condition prone to increased risk for some types of cancer and vice versa. This is necessary to keep in mind during rational drug design process for all therapies, which are based on AChE as a target molecule.
T2  - Current Medicinal Chemistry
T1  - Modulators of Acetylcholinesterase Activity: From Alzheimers Disease to Anti-Cancer Drugs
VL  - 24
IS  - 30
SP  - 3283
EP  - 3309
DO  - 10.2174/0929867324666170705123509
ER  - 

@article{
author = "Lazarević-Pašti, Tamara and Leskovac, Andreja and Momić, Tatjana and Petrović, Sandra and Vasić, Vesna M.",
year = "2017",
abstract = "Background: Acetylcholinesterase (AChE) is involved in the termination of impulse transmission by rapid hydrolysis of the neurotransmitter acetylcholine in numerous cholinergic pathways in the central and peripheral nervous systems. The enzyme inactivation leads to acetylcholine accumulation, hyperstimulation of nicotinic and muscarinic receptors, and disrupted neurotransmission. Hence, acetylcholinesterase inhibitors, interacting with the enzyme as their primary target, are applied as relevant drugs for different neurodegenerative diseases (such as Alzheimers and Parkinsons) as well as toxins. At the same time, there are increasing evidence that in non-neuronal context, AChE is involved in the regulation of cell proliferation, differentiation, apoptosis and cell-cell interaction. An irregular expression of AChE has been found in different types of tumors, suggesting the involvement of AChE in the regulation of tumor development. Having all this in mind, there is a possibility that some AChE inhibitors could be used as anti-cancer agents. Objective: This contribution will discuss a broad range of possible application of different AChE inhibitors as drugs, from well-known anti-Alzheimers disease drugs to their use in cancer treatment in future. Emphasis will be put on various known AChE inhibitors classes, whose application as drugs could be controversy, as well as on newly investigated natural products, which can also modulate AChE activity. Conclusion: It is not clear a patient treated for neurodegenerative condition prone to increased risk for some types of cancer and vice versa. This is necessary to keep in mind during rational drug design process for all therapies, which are based on AChE as a target molecule.",
journal = "Current Medicinal Chemistry",
title = "Modulators of Acetylcholinesterase Activity: From Alzheimers Disease to Anti-Cancer Drugs",
volume = "24",
number = "30",
pages = "3283-3309",
doi = "10.2174/0929867324666170705123509"
}

Lazarević-Pašti, T., Leskovac, A., Momić, T., Petrović, S.,& Vasić, V. M.. (2017). Modulators of Acetylcholinesterase Activity: From Alzheimers Disease to Anti-Cancer Drugs. in Current Medicinal Chemistry, 24(30), 3283-3309.
https://doi.org/10.2174/0929867324666170705123509

Lazarević-Pašti T, Leskovac A, Momić T, Petrović S, Vasić VM. Modulators of Acetylcholinesterase Activity: From Alzheimers Disease to Anti-Cancer Drugs. in Current Medicinal Chemistry. 2017;24(30):3283-3309.
doi:10.2174/0929867324666170705123509 .

Lazarević-Pašti, Tamara, Leskovac, Andreja, Momić, Tatjana, Petrović, Sandra, Vasić, Vesna M., "Modulators of Acetylcholinesterase Activity: From Alzheimers Disease to Anti-Cancer Drugs" in Current Medicinal Chemistry, 24, no. 30 (2017):3283-3309,
https://doi.org/10.2174/0929867324666170705123509 . .