TY  - JOUR
AU  - Batinić, Petar M.
AU  - Đorđević, Verica B.
AU  - Obradović, Nataša
AU  - Krstić, Aleksandar D.
AU  - Stevanović, Sanja I.
AU  - Balanč, Bojana
AU  - Marković, Smilja
AU  - Pjanović, Rada V.
AU  - Mijin, Dušan Ž.
AU  - Bugarski, Branko M.
PY  - 2023
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10851
AB  - Liposome-encapsulated folic acid is incorporated into the films made from sodium carboxymethyl cellulose (CMC) (2 mas%) and a mixture of CMC and solagum (9:1 w/w) using the film-forming cast solution method. Histidine is used to increase solubility for folic acid in liposomes (1–5 mg mL−1), and propylene glycol is used as a film plasticizer (2.6 mas%). The obtained films (50–60 µm tick) containing 3.12–20.19 mg of folic acid per gram of film are envisaged to be used as patches for transdermal delivery of folic acid. Therefore, some physical, mechanical, release and structural attributes of the films are scrutinized. Folic acid gives yellow color to the films and contributes to stronger chemical bonds which result in improved strength of the film. Liposomes prolong the release of folic acid from films to 24 h without adverse effects on mechanical properties of the films, but degrade homogeneity of the films, which can be ascribed to its agglomeration within the film matrix as revealed by atomic force microscopy. According to the release at pH 5.5, the film formulation based on a blend of CMC and solagum containing 3 mg mL−1 liposome-encapsulated folic acid is recommended. Practical Application: Folic acid is effective in reducing oxidative stress levels in the skin and neutralizing the harmful free radicals and is also essential for various metabolic reactions in the body. However, the limited solubility of folic acid linked with its poor absorption in an organism, low storage stability, short half-life upon oral consumption, specific food preferences of some people, extensive liver metabolism, and pregnancy-induced vomiting point to a large potential in transdermal usage of folic acid. This has motivated us to design new multicomponent polymer-lipid systems as an alternative solution to overcome some of these drawbacks. The results obtained for these multicomponent films pointed to their potential for prolonged release of folic acid to 24 h, which can also be useful for scientists interested in encapsulating similar poorly soluble compounds in CMC patches. The finding can be also valuable information for pharmaceutical manufacturers and scientists worldwide.
T2  - European Journal of Lipid Science and Technology
T1  - Polymer-Lipid Matrices based on Carboxymethyl Cellulose/Solagum and Liposomes for Controlled Release of Folic Acid
SP  - 2200169
DO  - 10.1002/ejlt.202200169
ER  - 

@article{
author = "Batinić, Petar M. and Đorđević, Verica B. and Obradović, Nataša and Krstić, Aleksandar D. and Stevanović, Sanja I. and Balanč, Bojana and Marković, Smilja and Pjanović, Rada V. and Mijin, Dušan Ž. and Bugarski, Branko M.",
year = "2023",
abstract = "Liposome-encapsulated folic acid is incorporated into the films made from sodium carboxymethyl cellulose (CMC) (2 mas%) and a mixture of CMC and solagum (9:1 w/w) using the film-forming cast solution method. Histidine is used to increase solubility for folic acid in liposomes (1–5 mg mL−1), and propylene glycol is used as a film plasticizer (2.6 mas%). The obtained films (50–60 µm tick) containing 3.12–20.19 mg of folic acid per gram of film are envisaged to be used as patches for transdermal delivery of folic acid. Therefore, some physical, mechanical, release and structural attributes of the films are scrutinized. Folic acid gives yellow color to the films and contributes to stronger chemical bonds which result in improved strength of the film. Liposomes prolong the release of folic acid from films to 24 h without adverse effects on mechanical properties of the films, but degrade homogeneity of the films, which can be ascribed to its agglomeration within the film matrix as revealed by atomic force microscopy. According to the release at pH 5.5, the film formulation based on a blend of CMC and solagum containing 3 mg mL−1 liposome-encapsulated folic acid is recommended. Practical Application: Folic acid is effective in reducing oxidative stress levels in the skin and neutralizing the harmful free radicals and is also essential for various metabolic reactions in the body. However, the limited solubility of folic acid linked with its poor absorption in an organism, low storage stability, short half-life upon oral consumption, specific food preferences of some people, extensive liver metabolism, and pregnancy-induced vomiting point to a large potential in transdermal usage of folic acid. This has motivated us to design new multicomponent polymer-lipid systems as an alternative solution to overcome some of these drawbacks. The results obtained for these multicomponent films pointed to their potential for prolonged release of folic acid to 24 h, which can also be useful for scientists interested in encapsulating similar poorly soluble compounds in CMC patches. The finding can be also valuable information for pharmaceutical manufacturers and scientists worldwide.",
journal = "European Journal of Lipid Science and Technology",
title = "Polymer-Lipid Matrices based on Carboxymethyl Cellulose/Solagum and Liposomes for Controlled Release of Folic Acid",
pages = "2200169",
doi = "10.1002/ejlt.202200169"
}

Batinić, P. M., Đorđević, V. B., Obradović, N., Krstić, A. D., Stevanović, S. I., Balanč, B., Marković, S., Pjanović, R. V., Mijin, D. Ž.,& Bugarski, B. M.. (2023). Polymer-Lipid Matrices based on Carboxymethyl Cellulose/Solagum and Liposomes for Controlled Release of Folic Acid. in European Journal of Lipid Science and Technology, 2200169.
https://doi.org/10.1002/ejlt.202200169

Batinić PM, Đorđević VB, Obradović N, Krstić AD, Stevanović SI, Balanč B, Marković S, Pjanović RV, Mijin DŽ, Bugarski BM. Polymer-Lipid Matrices based on Carboxymethyl Cellulose/Solagum and Liposomes for Controlled Release of Folic Acid. in European Journal of Lipid Science and Technology. 2023;:2200169.
doi:10.1002/ejlt.202200169 .

Batinić, Petar M., Đorđević, Verica B., Obradović, Nataša, Krstić, Aleksandar D., Stevanović, Sanja I., Balanč, Bojana, Marković, Smilja, Pjanović, Rada V., Mijin, Dušan Ž., Bugarski, Branko M., "Polymer-Lipid Matrices based on Carboxymethyl Cellulose/Solagum and Liposomes for Controlled Release of Folic Acid" in European Journal of Lipid Science and Technology (2023):2200169,
https://doi.org/10.1002/ejlt.202200169 . .

TY  - CONF
AU  - Marković, Maja D.
AU  - Panić, Vesna V.
AU  - Tadić, Julijana D.
AU  - Pjanović, Rada V.
PY  - 2021
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10884
AB  - Targeted drug delivery is powerful tool which researchers use to achieve safer and more efficienttherapy of many diseases, including various types of cancer. Many chemotherapeutics are poorly watersoluble, so their encapsulation and targeted delivery remain quite challenge. Hydrogels based onpoly(methacrylic acid) (PMAA) are widely investigated for targeted drug delivery due to their pHsensitivity, non-toxicity and biocompatibility. Still, due to the PMAA highly hydrophilic nature, PMAAcan only be used for encapsulation and targeted delivery of water-soluble drugs. Our previous researchwas directed towards overcoming this limitation: PMAA was modified with amphiphilic protein –casein and poorly-water soluble model drug – caffeine – was encapsulated (PMAC). Present study isfocused on investigation how variation of amount of one of the most important hydrogels networkparameter such as crosslinker affect PMAC swelling properties and caffeine release. The group ofhybrid hydrogels – PMAC – was synthesized with various amount of crosslinker: 0.4mol%, 0.8mol%,1.6mol% and 3.2mol% with respect to methacrylic acid. Swelling behavior of hybrid hydrogels andcaffeine release was investigated in two environments which simulated human stomach and intestines.Obtained results showed that targeted delivery of poorly water-soluble model drug was achieved andthat its release can be prolonged up to 24h. Also, kinetic of poorly water-soluble drug release can beeasily modified only by changing crosslinker amount. PMAC hybrid hydrogels have huge potential fortargeted delivery of poorly water-soluble active substances.
PB  - Kragujevac : University of Kragujevac, Institute for Information Technologies
C3  - ICCBIKG 2021 : 1st International Conference on Chemo and BioInformatics : Book of Proceedings
T1  - Effect of crosslinker amount on hybrid hydrogels swelling and drug release
SP  - 125
EP  - 128
DO  - 10.46793/ICCBI21.125M
ER  - 

@conference{
author = "Marković, Maja D. and Panić, Vesna V. and Tadić, Julijana D. and Pjanović, Rada V.",
year = "2021",
abstract = "Targeted drug delivery is powerful tool which researchers use to achieve safer and more efficienttherapy of many diseases, including various types of cancer. Many chemotherapeutics are poorly watersoluble, so their encapsulation and targeted delivery remain quite challenge. Hydrogels based onpoly(methacrylic acid) (PMAA) are widely investigated for targeted drug delivery due to their pHsensitivity, non-toxicity and biocompatibility. Still, due to the PMAA highly hydrophilic nature, PMAAcan only be used for encapsulation and targeted delivery of water-soluble drugs. Our previous researchwas directed towards overcoming this limitation: PMAA was modified with amphiphilic protein –casein and poorly-water soluble model drug – caffeine – was encapsulated (PMAC). Present study isfocused on investigation how variation of amount of one of the most important hydrogels networkparameter such as crosslinker affect PMAC swelling properties and caffeine release. The group ofhybrid hydrogels – PMAC – was synthesized with various amount of crosslinker: 0.4mol%, 0.8mol%,1.6mol% and 3.2mol% with respect to methacrylic acid. Swelling behavior of hybrid hydrogels andcaffeine release was investigated in two environments which simulated human stomach and intestines.Obtained results showed that targeted delivery of poorly water-soluble model drug was achieved andthat its release can be prolonged up to 24h. Also, kinetic of poorly water-soluble drug release can beeasily modified only by changing crosslinker amount. PMAC hybrid hydrogels have huge potential fortargeted delivery of poorly water-soluble active substances.",
publisher = "Kragujevac : University of Kragujevac, Institute for Information Technologies",
journal = "ICCBIKG 2021 : 1st International Conference on Chemo and BioInformatics : Book of Proceedings",
title = "Effect of crosslinker amount on hybrid hydrogels swelling and drug release",
pages = "125-128",
doi = "10.46793/ICCBI21.125M"
}

Marković, M. D., Panić, V. V., Tadić, J. D.,& Pjanović, R. V.. (2021). Effect of crosslinker amount on hybrid hydrogels swelling and drug release. in ICCBIKG 2021 : 1st International Conference on Chemo and BioInformatics : Book of Proceedings
Kragujevac : University of Kragujevac, Institute for Information Technologies., 125-128.
https://doi.org/10.46793/ICCBI21.125M

Marković MD, Panić VV, Tadić JD, Pjanović RV. Effect of crosslinker amount on hybrid hydrogels swelling and drug release. in ICCBIKG 2021 : 1st International Conference on Chemo and BioInformatics : Book of Proceedings. 2021;:125-128.
doi:10.46793/ICCBI21.125M .

Marković, Maja D., Panić, Vesna V., Tadić, Julijana D., Pjanović, Rada V., "Effect of crosslinker amount on hybrid hydrogels swelling and drug release" in ICCBIKG 2021 : 1st International Conference on Chemo and BioInformatics : Book of Proceedings (2021):125-128,
https://doi.org/10.46793/ICCBI21.125M . .

TY  - CONF
AU  - Marković, Maja D.
AU  - Tadić, Julijana
AU  - Pjanović, Rada V.
PY  - 2021
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/11423
AB  - Nowadays, humanity are faced with many challenges which affect health of people all aroundthe globe (such as climate change, new diseases and/or already present ones for which cure hasnot been found yet – cancer). The efforts of researchers on the field of drug delivery systemsbring everyday novel tools for safer and more effective therapy. pH sensitive hydrogels basedon poly(methacrylic acid) are recognized as materials with huge potential for controlled releaseof drugs. The encapsulation and controlled release of many chemotherapeutics is quitechallenge due to their poorly water-solubility. In our previous research we overcome thisproblem by modifying hydrophilic pol(methacrylic acid) with amphiphilic casein and showedthat prepared material have potential for encapsulation and controlled release of poorly watersoluble model drug – caffeine (PMAC carriers). In present study we deepened further ourresearch and employed various models: Ritger-Peppas, Higuchi and Kopcha model to analyzehow the change of crosslinker amount affect the mechanism of release kinetics of caffeine inmedium with pH of 6.8 (which simulated the environment in human intestines). Obtainedresults showed that only by changing one parameter such as crosslinker amount it is possible tofine tune the type of drug release mechanism, due to which the PMAC carriers would be ableto respond to the specific demands of therapy.
PB  - University of Szeged, H-6720 Szeged, Dugonics tér 13, Hungary
C3  - The 27 th International Symposium on Analytical and Environmental Problems
T1  - Analysis of kinetics of poorly water-soluble drug release from hydrogels based on poly(methacrylic acid) and casein with different crosslinker amount
SP  - 203
EP  - 207
UR  - https://hdl.handle.net/21.15107/rcub_vinar_11423
ER  - 

@conference{
author = "Marković, Maja D. and Tadić, Julijana and Pjanović, Rada V.",
year = "2021",
abstract = "Nowadays, humanity are faced with many challenges which affect health of people all aroundthe globe (such as climate change, new diseases and/or already present ones for which cure hasnot been found yet – cancer). The efforts of researchers on the field of drug delivery systemsbring everyday novel tools for safer and more effective therapy. pH sensitive hydrogels basedon poly(methacrylic acid) are recognized as materials with huge potential for controlled releaseof drugs. The encapsulation and controlled release of many chemotherapeutics is quitechallenge due to their poorly water-solubility. In our previous research we overcome thisproblem by modifying hydrophilic pol(methacrylic acid) with amphiphilic casein and showedthat prepared material have potential for encapsulation and controlled release of poorly watersoluble model drug – caffeine (PMAC carriers). In present study we deepened further ourresearch and employed various models: Ritger-Peppas, Higuchi and Kopcha model to analyzehow the change of crosslinker amount affect the mechanism of release kinetics of caffeine inmedium with pH of 6.8 (which simulated the environment in human intestines). Obtainedresults showed that only by changing one parameter such as crosslinker amount it is possible tofine tune the type of drug release mechanism, due to which the PMAC carriers would be ableto respond to the specific demands of therapy.",
publisher = "University of Szeged, H-6720 Szeged, Dugonics tér 13, Hungary",
journal = "The 27 th International Symposium on Analytical and Environmental Problems",
title = "Analysis of kinetics of poorly water-soluble drug release from hydrogels based on poly(methacrylic acid) and casein with different crosslinker amount",
pages = "203-207",
url = "https://hdl.handle.net/21.15107/rcub_vinar_11423"
}

Marković, M. D., Tadić, J.,& Pjanović, R. V.. (2021). Analysis of kinetics of poorly water-soluble drug release from hydrogels based on poly(methacrylic acid) and casein with different crosslinker amount. in The 27 th International Symposium on Analytical and Environmental Problems
University of Szeged, H-6720 Szeged, Dugonics tér 13, Hungary., 203-207.
https://hdl.handle.net/21.15107/rcub_vinar_11423

Marković MD, Tadić J, Pjanović RV. Analysis of kinetics of poorly water-soluble drug release from hydrogels based on poly(methacrylic acid) and casein with different crosslinker amount. in The 27 th International Symposium on Analytical and Environmental Problems. 2021;:203-207.
https://hdl.handle.net/21.15107/rcub_vinar_11423 .

Marković, Maja D., Tadić, Julijana, Pjanović, Rada V., "Analysis of kinetics of poorly water-soluble drug release from hydrogels based on poly(methacrylic acid) and casein with different crosslinker amount" in The 27 th International Symposium on Analytical and Environmental Problems (2021):203-207,
https://hdl.handle.net/21.15107/rcub_vinar_11423 .