Krstić, Danijela Z.

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  • Krstić, Danijela Z. (10)
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Author's Bibliography

Effects of homocysteine and its related compounds on oxygen consumption of the rat heart tissue homogenate: the role of different gasotransmitters

Jakovljević-Uzelac, Jovana; Stanić, Marina; Krstić, Danijela Z.; Čolović, Mirjana B.; Đurić, Dragan M.

(2018)

TY  - JOUR
AU  - Jakovljević-Uzelac, Jovana
AU  - Stanić, Marina
AU  - Krstić, Danijela Z.
AU  - Čolović, Mirjana B.
AU  - Đurić, Dragan M.
PY  - 2018
UR  - http://link.springer.com/10.1007/s11010-017-3238-z
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/7788
AB  - The objective of this study was to investigate in vitro effects of 10 A mu M dl-homocysteine (dl-Hcy), dl-homocysteine thiolactone-hydrochloride (dl-Hcy TLHC), and l-homocysteine thiolactone-hydrochloride (l-Hcy TLHC) on the oxygen consumption of rat heart tissue homogenate, as well as the involvement of the gasotransmitters NO, H2S and CO in the effects of the most toxic homocysteine compound, dl-Hcy TLHC. The possible contribution of the gasotransmitters in these effects was estimated by using the appropriate inhibitors of their synthesis (N (omega)-nitro-l-arginine methyl ester (l-NAME), dl-propargylglycine (dl-PAG), and zinc protoporphyrin IX (ZnPPR IX), respectively). The oxygen consumption of rat heart tissue homogenate was measured by Clark/type oxygen electrode in the absence and presence of the investigated compounds. All three homocysteine-based compounds caused a similar decrease in the oxygen consumption rate compared to control: 15.19 +/- 4.01%, 12.42 +/- 1.01%, and 16.43 +/- 4.52% for dl-Hcy, dl-Hcy TLHC, or l-Hcy TLHC, respectively. All applied inhibitors of gasotransmitter synthesis also decreased the oxygen consumption rate of tissue homogenate related to control: 13.53 +/- 1.35% for l-NAME (30 A mu M), 5.32 +/- 1.23% for dl-PAG (10 A mu M), and 5.56 +/- 1.39% for ZnPPR IX (10 A mu M). Simultaneous effect of l-NAME (30 A mu M) or ZnPPR IX (10 A mu M) with dl-Hcy TLHC (10 A mu M) caused a larger decrease of oxygen consumption compared to each of the substances individually. However, when dl-PAG (10 A mu M) was applied together with dl-Hcy TLHC (10 A mu M), it attenuated the effect of dl-Hcy TLHC from 12.42 +/- 1.01 to 9.22 +/- 1.58%. In conclusion, cardiotoxicity induced by Hcy-related compounds, which was shown in our previous research, could result from the inhibition of the oxygen consumption, and might be mediated by the certain gasotransmitters.
T2  - Molecular and Cellular Biochemistry
T1  - Effects of homocysteine and its related compounds on oxygen consumption of the rat heart tissue homogenate: the role of different gasotransmitters
VL  - 444
IS  - 1-2
SP  - 143
EP  - 148
DO  - 10.1007/s11010-017-3238-z
ER  - 
@article{
author = "Jakovljević-Uzelac, Jovana and Stanić, Marina and Krstić, Danijela Z. and Čolović, Mirjana B. and Đurić, Dragan M.",
year = "2018",
abstract = "The objective of this study was to investigate in vitro effects of 10 A mu M dl-homocysteine (dl-Hcy), dl-homocysteine thiolactone-hydrochloride (dl-Hcy TLHC), and l-homocysteine thiolactone-hydrochloride (l-Hcy TLHC) on the oxygen consumption of rat heart tissue homogenate, as well as the involvement of the gasotransmitters NO, H2S and CO in the effects of the most toxic homocysteine compound, dl-Hcy TLHC. The possible contribution of the gasotransmitters in these effects was estimated by using the appropriate inhibitors of their synthesis (N (omega)-nitro-l-arginine methyl ester (l-NAME), dl-propargylglycine (dl-PAG), and zinc protoporphyrin IX (ZnPPR IX), respectively). The oxygen consumption of rat heart tissue homogenate was measured by Clark/type oxygen electrode in the absence and presence of the investigated compounds. All three homocysteine-based compounds caused a similar decrease in the oxygen consumption rate compared to control: 15.19 +/- 4.01%, 12.42 +/- 1.01%, and 16.43 +/- 4.52% for dl-Hcy, dl-Hcy TLHC, or l-Hcy TLHC, respectively. All applied inhibitors of gasotransmitter synthesis also decreased the oxygen consumption rate of tissue homogenate related to control: 13.53 +/- 1.35% for l-NAME (30 A mu M), 5.32 +/- 1.23% for dl-PAG (10 A mu M), and 5.56 +/- 1.39% for ZnPPR IX (10 A mu M). Simultaneous effect of l-NAME (30 A mu M) or ZnPPR IX (10 A mu M) with dl-Hcy TLHC (10 A mu M) caused a larger decrease of oxygen consumption compared to each of the substances individually. However, when dl-PAG (10 A mu M) was applied together with dl-Hcy TLHC (10 A mu M), it attenuated the effect of dl-Hcy TLHC from 12.42 +/- 1.01 to 9.22 +/- 1.58%. In conclusion, cardiotoxicity induced by Hcy-related compounds, which was shown in our previous research, could result from the inhibition of the oxygen consumption, and might be mediated by the certain gasotransmitters.",
journal = "Molecular and Cellular Biochemistry",
title = "Effects of homocysteine and its related compounds on oxygen consumption of the rat heart tissue homogenate: the role of different gasotransmitters",
volume = "444",
number = "1-2",
pages = "143-148",
doi = "10.1007/s11010-017-3238-z"
}
Jakovljević-Uzelac, J., Stanić, M., Krstić, D. Z., Čolović, M. B.,& Đurić, D. M.. (2018). Effects of homocysteine and its related compounds on oxygen consumption of the rat heart tissue homogenate: the role of different gasotransmitters. in Molecular and Cellular Biochemistry, 444(1-2), 143-148.
https://doi.org/10.1007/s11010-017-3238-z
Jakovljević-Uzelac J, Stanić M, Krstić DZ, Čolović MB, Đurić DM. Effects of homocysteine and its related compounds on oxygen consumption of the rat heart tissue homogenate: the role of different gasotransmitters. in Molecular and Cellular Biochemistry. 2018;444(1-2):143-148.
doi:10.1007/s11010-017-3238-z .
Jakovljević-Uzelac, Jovana, Stanić, Marina, Krstić, Danijela Z., Čolović, Mirjana B., Đurić, Dragan M., "Effects of homocysteine and its related compounds on oxygen consumption of the rat heart tissue homogenate: the role of different gasotransmitters" in Molecular and Cellular Biochemistry, 444, no. 1-2 (2018):143-148,
https://doi.org/10.1007/s11010-017-3238-z . .
6
3

The effects of acute hyperhomocysteinemia induced by DL-homocysteine or DL-homocysteine thiolactone on serum biochemical parameters, plasma antioxidant enzyme and cardiac acetylcholinesterase activities in the rat

Kornjača, Duško; Živković, Vladimir I.; Krstić, Danijela Z.; Čolović, Mirjana B.; Đurić, Marko; Stanković, Sanja; Mutavdžin, Slavica; Jakovljević, Vladimir Lj.; Đurić, Dragan M.

(2018)

TY  - JOUR
AU  - Kornjača, Duško
AU  - Živković, Vladimir I.
AU  - Krstić, Danijela Z.
AU  - Čolović, Mirjana B.
AU  - Đurić, Marko
AU  - Stanković, Sanja
AU  - Mutavdžin, Slavica
AU  - Jakovljević, Vladimir Lj.
AU  - Đurić, Dragan M.
PY  - 2018
UR  - http://www.doiserbia.nb.rs/Article.aspx?ID=0354-46641700041K
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/7714
AB  - The aim of this study was to assess the effects of DL-homocysteine (DL-Hcy) and DL-homocysteine thiolactone (DL-Hcy TLHC) on selected serum biochemical parameters, markers of oxidative stress and the activities of antioxidant enzymes (catalase (CAT), glutathione peroxidase (GPx), superoxide dismutase (SOD)) in the plasma, as well as on acetylcholinesterase (AChE) activity in the cardiac tissue homogenate in the rat. Male Wistar rats were divided into three groups as follows: control group (1 mL 0.9% NaCl, intraperitoneal (i.p.) injection), DL-Hcy group (8 mmol/kg body mass (b.m.), i.p.) or DL-Hcy TLHC group (8 mmol/kg b.m., i.p.). One hour after administration, the rats were euthanized, whole blood was collected for biochemical analysis, and the heart was excised. Following the i.p. administration of DL-Hcy and DL-Hcy TLHC, the activities of antioxidant enzymes were mostly significantly increased, while plasma malondialdehyde (MDA) was decreased. Administration of DL-Hcy and DL-Hcy TLHC significantly inhibited AChE activity in rat cardiac tissue. Our findings suggest that DL-Hcy and DL-Hcy TLHC exerted prooxidant effects; however, the decrease in MDA points to an inverse response to the increase in antioxidant enzyme activities. While both substances inhibited AChE activity in rat cardiac tissue, DL-Hcy TLHC induced stronger effects than DL-Hcy.
T2  - Archives of Biological Sciences
T1  - The effects of acute hyperhomocysteinemia induced by DL-homocysteine or DL-homocysteine thiolactone on serum biochemical parameters, plasma antioxidant enzyme and cardiac acetylcholinesterase activities in the rat
VL  - 70
IS  - 2
SP  - 241
EP  - 248
DO  - 10.2298/ABS170731041K
ER  - 
@article{
author = "Kornjača, Duško and Živković, Vladimir I. and Krstić, Danijela Z. and Čolović, Mirjana B. and Đurić, Marko and Stanković, Sanja and Mutavdžin, Slavica and Jakovljević, Vladimir Lj. and Đurić, Dragan M.",
year = "2018",
abstract = "The aim of this study was to assess the effects of DL-homocysteine (DL-Hcy) and DL-homocysteine thiolactone (DL-Hcy TLHC) on selected serum biochemical parameters, markers of oxidative stress and the activities of antioxidant enzymes (catalase (CAT), glutathione peroxidase (GPx), superoxide dismutase (SOD)) in the plasma, as well as on acetylcholinesterase (AChE) activity in the cardiac tissue homogenate in the rat. Male Wistar rats were divided into three groups as follows: control group (1 mL 0.9% NaCl, intraperitoneal (i.p.) injection), DL-Hcy group (8 mmol/kg body mass (b.m.), i.p.) or DL-Hcy TLHC group (8 mmol/kg b.m., i.p.). One hour after administration, the rats were euthanized, whole blood was collected for biochemical analysis, and the heart was excised. Following the i.p. administration of DL-Hcy and DL-Hcy TLHC, the activities of antioxidant enzymes were mostly significantly increased, while plasma malondialdehyde (MDA) was decreased. Administration of DL-Hcy and DL-Hcy TLHC significantly inhibited AChE activity in rat cardiac tissue. Our findings suggest that DL-Hcy and DL-Hcy TLHC exerted prooxidant effects; however, the decrease in MDA points to an inverse response to the increase in antioxidant enzyme activities. While both substances inhibited AChE activity in rat cardiac tissue, DL-Hcy TLHC induced stronger effects than DL-Hcy.",
journal = "Archives of Biological Sciences",
title = "The effects of acute hyperhomocysteinemia induced by DL-homocysteine or DL-homocysteine thiolactone on serum biochemical parameters, plasma antioxidant enzyme and cardiac acetylcholinesterase activities in the rat",
volume = "70",
number = "2",
pages = "241-248",
doi = "10.2298/ABS170731041K"
}
Kornjača, D., Živković, V. I., Krstić, D. Z., Čolović, M. B., Đurić, M., Stanković, S., Mutavdžin, S., Jakovljević, V. Lj.,& Đurić, D. M.. (2018). The effects of acute hyperhomocysteinemia induced by DL-homocysteine or DL-homocysteine thiolactone on serum biochemical parameters, plasma antioxidant enzyme and cardiac acetylcholinesterase activities in the rat. in Archives of Biological Sciences, 70(2), 241-248.
https://doi.org/10.2298/ABS170731041K
Kornjača D, Živković VI, Krstić DZ, Čolović MB, Đurić M, Stanković S, Mutavdžin S, Jakovljević VL, Đurić DM. The effects of acute hyperhomocysteinemia induced by DL-homocysteine or DL-homocysteine thiolactone on serum biochemical parameters, plasma antioxidant enzyme and cardiac acetylcholinesterase activities in the rat. in Archives of Biological Sciences. 2018;70(2):241-248.
doi:10.2298/ABS170731041K .
Kornjača, Duško, Živković, Vladimir I., Krstić, Danijela Z., Čolović, Mirjana B., Đurić, Marko, Stanković, Sanja, Mutavdžin, Slavica, Jakovljević, Vladimir Lj., Đurić, Dragan M., "The effects of acute hyperhomocysteinemia induced by DL-homocysteine or DL-homocysteine thiolactone on serum biochemical parameters, plasma antioxidant enzyme and cardiac acetylcholinesterase activities in the rat" in Archives of Biological Sciences, 70, no. 2 (2018):241-248,
https://doi.org/10.2298/ABS170731041K . .
1

Modulation of rat synaptosomal ATPases and acetylcholinesterase activities induced by chronic exposure to the static magnetic field

Dinčić, Marko; Krstić, Danijela Z.; Čolović, Mirjana B.; Nešović Ostojić, Jelena; Kovačević, Sanjin; De Luka, Silvio R.; Đorđević, Drago M.; Ćirković, Saša; Brkić, Predrag; Todorović, Jasna

(2018)

TY  - JOUR
AU  - Dinčić, Marko
AU  - Krstić, Danijela Z.
AU  - Čolović, Mirjana B.
AU  - Nešović Ostojić, Jelena
AU  - Kovačević, Sanjin
AU  - De Luka, Silvio R.
AU  - Đorđević, Drago M.
AU  - Ćirković, Saša
AU  - Brkić, Predrag
AU  - Todorović, Jasna
PY  - 2018
UR  - https://www.tandfonline.com/doi/full/10.1080/09553002.2018.1518611
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/7957
AB  - Purpose: It is considered that exposure to static magnetic fields (SMF) may have both detrimental and therapeutic effect, but the mechanism of SMF influence on the living organisms is not well understood. Since the adenosine triphosphatases (ATPases) and acetylcholinesterase (AChE) are involved in both physiological and pathological processes, the modulation of Na+/K+-ATPase, ecto-ATPases and AChE activities, as well as oxidative stress responses were followed in synaptosomes isolated from rats after chronic exposure toward differently oriented SMF. Material and methods: Wistar albino rats were randomly divided into three experimental groups (six animals per group): Up and Down group - exposed to upward and downward oriented SMF, respectively, and Control group. After 50 days, the rats were sacrificed, and synaptosomes were isolated from the whole rat brain and used for testing the enzyme activities and oxidative stress parameters. Results: Chronic exposure to 1 mT SMF significantly increased ATPases, AChE activities, and malondialdehyde (MDA) level in both exposed groups, compared to control values. The significant decrease in synaptosomal catalase activity (1.48 ± 0.17 U/mg protein) induced by exposure to the downward oriented field, compared to those obtained for Control group (2.60 ± 0.29 U/mg protein), and Up group (2.72 ± 0.21 U/mg protein). Conclusions: It could be concluded that chronic exposure to differently oriented SMF increases ATPases and AChE activities in rat synaptosomes. Since brain ATPases and AChE have important roles in the pathogenesis of several neurological diseases, SMF influence on the activity of these enzymes may have potential therapeutic importance. © 2018, Copyright © 2018 Taylor & Francis Group, LLC.
T2  - International Journal of Radiation Biology
T1  - Modulation of rat synaptosomal ATPases and acetylcholinesterase activities induced by chronic exposure to the static magnetic field
VL  - 94
IS  - 11
SP  - 1062
EP  - 1071
DO  - 10.1080/09553002.2018.1518611
ER  - 
@article{
author = "Dinčić, Marko and Krstić, Danijela Z. and Čolović, Mirjana B. and Nešović Ostojić, Jelena and Kovačević, Sanjin and De Luka, Silvio R. and Đorđević, Drago M. and Ćirković, Saša and Brkić, Predrag and Todorović, Jasna",
year = "2018",
abstract = "Purpose: It is considered that exposure to static magnetic fields (SMF) may have both detrimental and therapeutic effect, but the mechanism of SMF influence on the living organisms is not well understood. Since the adenosine triphosphatases (ATPases) and acetylcholinesterase (AChE) are involved in both physiological and pathological processes, the modulation of Na+/K+-ATPase, ecto-ATPases and AChE activities, as well as oxidative stress responses were followed in synaptosomes isolated from rats after chronic exposure toward differently oriented SMF. Material and methods: Wistar albino rats were randomly divided into three experimental groups (six animals per group): Up and Down group - exposed to upward and downward oriented SMF, respectively, and Control group. After 50 days, the rats were sacrificed, and synaptosomes were isolated from the whole rat brain and used for testing the enzyme activities and oxidative stress parameters. Results: Chronic exposure to 1 mT SMF significantly increased ATPases, AChE activities, and malondialdehyde (MDA) level in both exposed groups, compared to control values. The significant decrease in synaptosomal catalase activity (1.48 ± 0.17 U/mg protein) induced by exposure to the downward oriented field, compared to those obtained for Control group (2.60 ± 0.29 U/mg protein), and Up group (2.72 ± 0.21 U/mg protein). Conclusions: It could be concluded that chronic exposure to differently oriented SMF increases ATPases and AChE activities in rat synaptosomes. Since brain ATPases and AChE have important roles in the pathogenesis of several neurological diseases, SMF influence on the activity of these enzymes may have potential therapeutic importance. © 2018, Copyright © 2018 Taylor & Francis Group, LLC.",
journal = "International Journal of Radiation Biology",
title = "Modulation of rat synaptosomal ATPases and acetylcholinesterase activities induced by chronic exposure to the static magnetic field",
volume = "94",
number = "11",
pages = "1062-1071",
doi = "10.1080/09553002.2018.1518611"
}
Dinčić, M., Krstić, D. Z., Čolović, M. B., Nešović Ostojić, J., Kovačević, S., De Luka, S. R., Đorđević, D. M., Ćirković, S., Brkić, P.,& Todorović, J.. (2018). Modulation of rat synaptosomal ATPases and acetylcholinesterase activities induced by chronic exposure to the static magnetic field. in International Journal of Radiation Biology, 94(11), 1062-1071.
https://doi.org/10.1080/09553002.2018.1518611
Dinčić M, Krstić DZ, Čolović MB, Nešović Ostojić J, Kovačević S, De Luka SR, Đorđević DM, Ćirković S, Brkić P, Todorović J. Modulation of rat synaptosomal ATPases and acetylcholinesterase activities induced by chronic exposure to the static magnetic field. in International Journal of Radiation Biology. 2018;94(11):1062-1071.
doi:10.1080/09553002.2018.1518611 .
Dinčić, Marko, Krstić, Danijela Z., Čolović, Mirjana B., Nešović Ostojić, Jelena, Kovačević, Sanjin, De Luka, Silvio R., Đorđević, Drago M., Ćirković, Saša, Brkić, Predrag, Todorović, Jasna, "Modulation of rat synaptosomal ATPases and acetylcholinesterase activities induced by chronic exposure to the static magnetic field" in International Journal of Radiation Biology, 94, no. 11 (2018):1062-1071,
https://doi.org/10.1080/09553002.2018.1518611 . .
1
3
2
2

The effects of N-acetyl-L-cysteine on subchronic methionine load in male wistar rats: Focus on standard biochemical parameters and markers of homocysteine metabolism in blood

Đurić, Aleksandar; Čolović, Mirjana B.; Krstić, Danijela Z.; Obrenović, Radmila; Micovic, Z; Đurić, Marija; Đurić, Dragan M.

(2018)

TY  - CONF
AU  - Đurić, Aleksandar
AU  - Čolović, Mirjana B.
AU  - Krstić, Danijela Z.
AU  - Obrenović, Radmila
AU  - Micovic, Z
AU  - Đurić, Marija
AU  - Đurić, Dragan M.
PY  - 2018
UR  - https://linkinghub.elsevier.com/retrieve/pii/S0021915018309547
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/7954
C3  - Atherosclerosis
T1  - The effects of N-acetyl-L-cysteine on subchronic methionine load in male wistar rats: Focus on standard biochemical parameters and markers of homocysteine metabolism in blood
VL  - 275
SP  - e206
EP  - e207
DO  - 10.1016/j.atherosclerosis.2018.06.642
ER  - 
@conference{
author = "Đurić, Aleksandar and Čolović, Mirjana B. and Krstić, Danijela Z. and Obrenović, Radmila and Micovic, Z and Đurić, Marija and Đurić, Dragan M.",
year = "2018",
journal = "Atherosclerosis",
title = "The effects of N-acetyl-L-cysteine on subchronic methionine load in male wistar rats: Focus on standard biochemical parameters and markers of homocysteine metabolism in blood",
volume = "275",
pages = "e206-e207",
doi = "10.1016/j.atherosclerosis.2018.06.642"
}
Đurić, A., Čolović, M. B., Krstić, D. Z., Obrenović, R., Micovic, Z., Đurić, M.,& Đurić, D. M.. (2018). The effects of N-acetyl-L-cysteine on subchronic methionine load in male wistar rats: Focus on standard biochemical parameters and markers of homocysteine metabolism in blood. in Atherosclerosis, 275, e206-e207.
https://doi.org/10.1016/j.atherosclerosis.2018.06.642
Đurić A, Čolović MB, Krstić DZ, Obrenović R, Micovic Z, Đurić M, Đurić DM. The effects of N-acetyl-L-cysteine on subchronic methionine load in male wistar rats: Focus on standard biochemical parameters and markers of homocysteine metabolism in blood. in Atherosclerosis. 2018;275:e206-e207.
doi:10.1016/j.atherosclerosis.2018.06.642 .
Đurić, Aleksandar, Čolović, Mirjana B., Krstić, Danijela Z., Obrenović, Radmila, Micovic, Z, Đurić, Marija, Đurić, Dragan M., "The effects of N-acetyl-L-cysteine on subchronic methionine load in male wistar rats: Focus on standard biochemical parameters and markers of homocysteine metabolism in blood" in Atherosclerosis, 275 (2018):e206-e207,
https://doi.org/10.1016/j.atherosclerosis.2018.06.642 . .

Hyperhomocysteinemia Induced By Methionine Nutritional Overload More Promptly Affects Brain Than Heart Cholinergic System Without Affects on Food Intake and Body Mass Gain

Hrncic, Dragan; Rasic-Markovic, Aleksandra; Čolović, Mirjana B.; Krstić, Danijela Z.; Sutulovic, Nikola; Grubac, Zeljko; Susic, Veselinka; Đurić, Dragan M.; Stanojlovic, Olivera

(2017)

TY  - CONF
AU  - Hrncic, Dragan
AU  - Rasic-Markovic, Aleksandra
AU  - Čolović, Mirjana B.
AU  - Krstić, Danijela Z.
AU  - Sutulovic, Nikola
AU  - Grubac, Zeljko
AU  - Susic, Veselinka
AU  - Đurić, Dragan M.
AU  - Stanojlovic, Olivera
PY  - 2017
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/7176
C3  - Atherosclerosis
T1  - Hyperhomocysteinemia Induced By Methionine Nutritional Overload More Promptly Affects Brain Than Heart Cholinergic System Without Affects on Food Intake and Body Mass Gain
VL  - 263
SP  - E168
EP  - E168
DO  - 10.1016/j.atherosclerosis.2017.06.536
ER  - 
@conference{
author = "Hrncic, Dragan and Rasic-Markovic, Aleksandra and Čolović, Mirjana B. and Krstić, Danijela Z. and Sutulovic, Nikola and Grubac, Zeljko and Susic, Veselinka and Đurić, Dragan M. and Stanojlovic, Olivera",
year = "2017",
journal = "Atherosclerosis",
title = "Hyperhomocysteinemia Induced By Methionine Nutritional Overload More Promptly Affects Brain Than Heart Cholinergic System Without Affects on Food Intake and Body Mass Gain",
volume = "263",
pages = "E168-E168",
doi = "10.1016/j.atherosclerosis.2017.06.536"
}
Hrncic, D., Rasic-Markovic, A., Čolović, M. B., Krstić, D. Z., Sutulovic, N., Grubac, Z., Susic, V., Đurić, D. M.,& Stanojlovic, O.. (2017). Hyperhomocysteinemia Induced By Methionine Nutritional Overload More Promptly Affects Brain Than Heart Cholinergic System Without Affects on Food Intake and Body Mass Gain. in Atherosclerosis, 263, E168-E168.
https://doi.org/10.1016/j.atherosclerosis.2017.06.536
Hrncic D, Rasic-Markovic A, Čolović MB, Krstić DZ, Sutulovic N, Grubac Z, Susic V, Đurić DM, Stanojlovic O. Hyperhomocysteinemia Induced By Methionine Nutritional Overload More Promptly Affects Brain Than Heart Cholinergic System Without Affects on Food Intake and Body Mass Gain. in Atherosclerosis. 2017;263:E168-E168.
doi:10.1016/j.atherosclerosis.2017.06.536 .
Hrncic, Dragan, Rasic-Markovic, Aleksandra, Čolović, Mirjana B., Krstić, Danijela Z., Sutulovic, Nikola, Grubac, Zeljko, Susic, Veselinka, Đurić, Dragan M., Stanojlovic, Olivera, "Hyperhomocysteinemia Induced By Methionine Nutritional Overload More Promptly Affects Brain Than Heart Cholinergic System Without Affects on Food Intake and Body Mass Gain" in Atherosclerosis, 263 (2017):E168-E168,
https://doi.org/10.1016/j.atherosclerosis.2017.06.536 . .

The Effects of Nitric Oxide Synthase Inhibition Following Acute Administration of Homocysteine on Oxidative Stress Markers in Rat Plasma

Jakovljević-Uzelac, Jovana; Čolović, Mirjana B.; Krstić, Danijela Z.; Đurić, Marko; Đurić, Dragan M.

(2017)

TY  - CONF
AU  - Jakovljević-Uzelac, Jovana
AU  - Čolović, Mirjana B.
AU  - Krstić, Danijela Z.
AU  - Đurić, Marko
AU  - Đurić, Dragan M.
PY  - 2017
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/7175
C3  - Atherosclerosis
T1  - The Effects of Nitric Oxide Synthase Inhibition Following Acute Administration of Homocysteine on Oxidative Stress Markers in Rat Plasma
VL  - 263
SP  - E137
EP  - E138
DO  - 10.1016/j.atherosclerosis.2017.06.440
ER  - 
@conference{
author = "Jakovljević-Uzelac, Jovana and Čolović, Mirjana B. and Krstić, Danijela Z. and Đurić, Marko and Đurić, Dragan M.",
year = "2017",
journal = "Atherosclerosis",
title = "The Effects of Nitric Oxide Synthase Inhibition Following Acute Administration of Homocysteine on Oxidative Stress Markers in Rat Plasma",
volume = "263",
pages = "E137-E138",
doi = "10.1016/j.atherosclerosis.2017.06.440"
}
Jakovljević-Uzelac, J., Čolović, M. B., Krstić, D. Z., Đurić, M.,& Đurić, D. M.. (2017). The Effects of Nitric Oxide Synthase Inhibition Following Acute Administration of Homocysteine on Oxidative Stress Markers in Rat Plasma. in Atherosclerosis, 263, E137-E138.
https://doi.org/10.1016/j.atherosclerosis.2017.06.440
Jakovljević-Uzelac J, Čolović MB, Krstić DZ, Đurić M, Đurić DM. The Effects of Nitric Oxide Synthase Inhibition Following Acute Administration of Homocysteine on Oxidative Stress Markers in Rat Plasma. in Atherosclerosis. 2017;263:E137-E138.
doi:10.1016/j.atherosclerosis.2017.06.440 .
Jakovljević-Uzelac, Jovana, Čolović, Mirjana B., Krstić, Danijela Z., Đurić, Marko, Đurić, Dragan M., "The Effects of Nitric Oxide Synthase Inhibition Following Acute Administration of Homocysteine on Oxidative Stress Markers in Rat Plasma" in Atherosclerosis, 263 (2017):E137-E138,
https://doi.org/10.1016/j.atherosclerosis.2017.06.440 . .

The effect of subchronic supplementation with folic acid and L-arginine on homocysteine-induced seizures

Rašić-Marković, Aleksandra; Hrnčić, Dragan; Krstić, Danijela Z.; Čolović, Mirjana B.; Djuric, E.; Rankov-Petrovic, B.; Šušić, Veselinka; Stanojlović, Olivera; Đurić, Dragan M.

(2016)

TY  - JOUR
AU  - Rašić-Marković, Aleksandra
AU  - Hrnčić, Dragan
AU  - Krstić, Danijela Z.
AU  - Čolović, Mirjana B.
AU  - Djuric, E.
AU  - Rankov-Petrovic, B.
AU  - Šušić, Veselinka
AU  - Stanojlović, Olivera
AU  - Đurić, Dragan M.
PY  - 2016
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/7114
AB  - The aim of the present study was to examine the effect of subchronic co-administration of folic acid (F) and L-arginine (A) on behavioural and electroencephalographic (EEG) characteristics of DL homocysteine thiolactone (H) induced seizures in adult rats. The activity of membrane ATPases in different brain regions were also investigated. Rats were treated with F, A, or vehicle for 15 days (regimen: F 5 mg/kg + A 500 mg/kg (F5A500); F 10 mg/kg + A 300 mg/kg (F10A300)). Seizures were elicited by convulsive dose of H (H, F5A500H, F10A300H) Subchronic supplementation with F and A did not affect seizure incidence, number of seizure episodes, and severity in F5A500H and F10A300H groups vs. H group. However, a tendency to increase latency and decrease the number of seizure episodes was noticed in the F10A300H group. EEG mean spectral power densities during ictal periods were significantly lower in F10A300H vs. H group. The activity of Na+/K+-ATPase and Mg2+-ATPase was significantly increased in almost all examined structures in rats treated with F and A. We can conclude that subchronic supplementation with folic acid and L-arginine has an antiepileptic effect in DL homocysteine thiolactone induced epilepsy.
T2  - Canadian Journal of Physiology and Pharmacology
T1  - The effect of subchronic supplementation with folic acid and L-arginine on homocysteine-induced seizures
VL  - 94
IS  - 10
SP  - 1083
EP  - 1089
DO  - 10.1139/cjpp-2016-0076
ER  - 
@article{
author = "Rašić-Marković, Aleksandra and Hrnčić, Dragan and Krstić, Danijela Z. and Čolović, Mirjana B. and Djuric, E. and Rankov-Petrovic, B. and Šušić, Veselinka and Stanojlović, Olivera and Đurić, Dragan M.",
year = "2016",
abstract = "The aim of the present study was to examine the effect of subchronic co-administration of folic acid (F) and L-arginine (A) on behavioural and electroencephalographic (EEG) characteristics of DL homocysteine thiolactone (H) induced seizures in adult rats. The activity of membrane ATPases in different brain regions were also investigated. Rats were treated with F, A, or vehicle for 15 days (regimen: F 5 mg/kg + A 500 mg/kg (F5A500); F 10 mg/kg + A 300 mg/kg (F10A300)). Seizures were elicited by convulsive dose of H (H, F5A500H, F10A300H) Subchronic supplementation with F and A did not affect seizure incidence, number of seizure episodes, and severity in F5A500H and F10A300H groups vs. H group. However, a tendency to increase latency and decrease the number of seizure episodes was noticed in the F10A300H group. EEG mean spectral power densities during ictal periods were significantly lower in F10A300H vs. H group. The activity of Na+/K+-ATPase and Mg2+-ATPase was significantly increased in almost all examined structures in rats treated with F and A. We can conclude that subchronic supplementation with folic acid and L-arginine has an antiepileptic effect in DL homocysteine thiolactone induced epilepsy.",
journal = "Canadian Journal of Physiology and Pharmacology",
title = "The effect of subchronic supplementation with folic acid and L-arginine on homocysteine-induced seizures",
volume = "94",
number = "10",
pages = "1083-1089",
doi = "10.1139/cjpp-2016-0076"
}
Rašić-Marković, A., Hrnčić, D., Krstić, D. Z., Čolović, M. B., Djuric, E., Rankov-Petrovic, B., Šušić, V., Stanojlović, O.,& Đurić, D. M.. (2016). The effect of subchronic supplementation with folic acid and L-arginine on homocysteine-induced seizures. in Canadian Journal of Physiology and Pharmacology, 94(10), 1083-1089.
https://doi.org/10.1139/cjpp-2016-0076
Rašić-Marković A, Hrnčić D, Krstić DZ, Čolović MB, Djuric E, Rankov-Petrovic B, Šušić V, Stanojlović O, Đurić DM. The effect of subchronic supplementation with folic acid and L-arginine on homocysteine-induced seizures. in Canadian Journal of Physiology and Pharmacology. 2016;94(10):1083-1089.
doi:10.1139/cjpp-2016-0076 .
Rašić-Marković, Aleksandra, Hrnčić, Dragan, Krstić, Danijela Z., Čolović, Mirjana B., Djuric, E., Rankov-Petrovic, B., Šušić, Veselinka, Stanojlović, Olivera, Đurić, Dragan M., "The effect of subchronic supplementation with folic acid and L-arginine on homocysteine-induced seizures" in Canadian Journal of Physiology and Pharmacology, 94, no. 10 (2016):1083-1089,
https://doi.org/10.1139/cjpp-2016-0076 . .
8
9
10

Effective Dose for Real Population Exposed to Indoor Radon in Dwellings of the Former Uranium Mine Area Kalna (Eastern Serbia)

Vucic, D. A.; Nikezić, Dragoslav; Vaupotič, Janja; Stojanovska, Zdenka A.; Krstić, Danijela Z.; Žunić, Zora S.

(2013)

TY  - JOUR
AU  - Vucic, D. A.
AU  - Nikezić, Dragoslav
AU  - Vaupotič, Janja
AU  - Stojanovska, Zdenka A.
AU  - Krstić, Danijela Z.
AU  - Žunić, Zora S.
PY  - 2013
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/7002
AB  - This paper deals with calculated effective doses that members of real population received from radon gas and its short lived progeny during air inhalation in their dwellings at field site Kalna in Eastern Serbia. There are two crucial parameters in effective dose calculation: Dose Conversion Factor (DCF) for particular subjects (including real gender, age and physical activity level) and indoor concentration of radon and its short lived progeny in field area. According to the results of indoor radon measurements in the area of former uranium mine, Kalna, the effective dose for this real population was estimated by using the dosimetric lung model, developed by authors according ICRP Publication 66. Authentic software was developed for determination of effective dose per unit inhaled activity of radon progeny, DCF expressed in unit [mSv/WLM]. The results, obtained according to ICRP 66 dosimeter lung model, were compared with results calculated according to ICRP Publication 65. The dosimetric results were, also, compared and discussed with epidemiological approach data, according to UNSCEAR.
T2  - Romanian Journal of Physics
T1  - Effective Dose for Real Population Exposed to Indoor Radon in Dwellings of the Former Uranium Mine Area Kalna (Eastern Serbia)
VL  - 58
SP  - S336
EP  - S347
ER  - 
@article{
author = "Vucic, D. A. and Nikezić, Dragoslav and Vaupotič, Janja and Stojanovska, Zdenka A. and Krstić, Danijela Z. and Žunić, Zora S.",
year = "2013",
abstract = "This paper deals with calculated effective doses that members of real population received from radon gas and its short lived progeny during air inhalation in their dwellings at field site Kalna in Eastern Serbia. There are two crucial parameters in effective dose calculation: Dose Conversion Factor (DCF) for particular subjects (including real gender, age and physical activity level) and indoor concentration of radon and its short lived progeny in field area. According to the results of indoor radon measurements in the area of former uranium mine, Kalna, the effective dose for this real population was estimated by using the dosimetric lung model, developed by authors according ICRP Publication 66. Authentic software was developed for determination of effective dose per unit inhaled activity of radon progeny, DCF expressed in unit [mSv/WLM]. The results, obtained according to ICRP 66 dosimeter lung model, were compared with results calculated according to ICRP Publication 65. The dosimetric results were, also, compared and discussed with epidemiological approach data, according to UNSCEAR.",
journal = "Romanian Journal of Physics",
title = "Effective Dose for Real Population Exposed to Indoor Radon in Dwellings of the Former Uranium Mine Area Kalna (Eastern Serbia)",
volume = "58",
pages = "S336-S347"
}
Vucic, D. A., Nikezić, D., Vaupotič, J., Stojanovska, Z. A., Krstić, D. Z.,& Žunić, Z. S.. (2013). Effective Dose for Real Population Exposed to Indoor Radon in Dwellings of the Former Uranium Mine Area Kalna (Eastern Serbia). in Romanian Journal of Physics, 58, S336-S347.
Vucic DA, Nikezić D, Vaupotič J, Stojanovska ZA, Krstić DZ, Žunić ZS. Effective Dose for Real Population Exposed to Indoor Radon in Dwellings of the Former Uranium Mine Area Kalna (Eastern Serbia). in Romanian Journal of Physics. 2013;58:S336-S347..
Vucic, D. A., Nikezić, Dragoslav, Vaupotič, Janja, Stojanovska, Zdenka A., Krstić, Danijela Z., Žunić, Zora S., "Effective Dose for Real Population Exposed to Indoor Radon in Dwellings of the Former Uranium Mine Area Kalna (Eastern Serbia)" in Romanian Journal of Physics, 58 (2013):S336-S347.
1

Na+/K+-ATPase: Activity and inhibition

Čolović, Mirjana B.; Krstić, Danijela Z.; Krinulović, Katarina; Momić, Tatjana; Savić, Jasmina; Vujačić, Ana V.; Vasić, Vesna M.

(2009)

TY  - JOUR
AU  - Čolović, Mirjana B.
AU  - Krstić, Danijela Z.
AU  - Krinulović, Katarina
AU  - Momić, Tatjana
AU  - Savić, Jasmina
AU  - Vujačić, Ana V.
AU  - Vasić, Vesna M.
PY  - 2009
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/6815
AB  - The aim of the study was to give an overview of the mechanism of inhibition of Na+/K+-ATPase activity induced by some specific and non specific inhibitors. For this purpose, the effects of some ouabain like compounds (digoxin, gitoxin), noble metals complexes ([PtCl2DMSO2], [AuCl4](-), [PdCl4](2-), [PdCl(dien)](+), [PdCl(Me(4)dien)](+)), transition metal ions (Cu2+, Zn2+, Fe2+, Co2+), and heavy metal ions (Hg2+, Pb2+, Cd2+) on the activity of Na+/K+-ATPase from rat synaptic plasma membranes (SPM), porcine cerebral cortex and human erythrocytes were discussed.
T2  - Russian Journal of Physical Chemistry A
T1  - Na+/K+-ATPase: Activity and inhibition
VL  - 83
IS  - 9
SP  - 1602
EP  - 1608
DO  - 10.1134/S0036024409090337
ER  - 
@article{
author = "Čolović, Mirjana B. and Krstić, Danijela Z. and Krinulović, Katarina and Momić, Tatjana and Savić, Jasmina and Vujačić, Ana V. and Vasić, Vesna M.",
year = "2009",
abstract = "The aim of the study was to give an overview of the mechanism of inhibition of Na+/K+-ATPase activity induced by some specific and non specific inhibitors. For this purpose, the effects of some ouabain like compounds (digoxin, gitoxin), noble metals complexes ([PtCl2DMSO2], [AuCl4](-), [PdCl4](2-), [PdCl(dien)](+), [PdCl(Me(4)dien)](+)), transition metal ions (Cu2+, Zn2+, Fe2+, Co2+), and heavy metal ions (Hg2+, Pb2+, Cd2+) on the activity of Na+/K+-ATPase from rat synaptic plasma membranes (SPM), porcine cerebral cortex and human erythrocytes were discussed.",
journal = "Russian Journal of Physical Chemistry A",
title = "Na+/K+-ATPase: Activity and inhibition",
volume = "83",
number = "9",
pages = "1602-1608",
doi = "10.1134/S0036024409090337"
}
Čolović, M. B., Krstić, D. Z., Krinulović, K., Momić, T., Savić, J., Vujačić, A. V.,& Vasić, V. M.. (2009). Na+/K+-ATPase: Activity and inhibition. in Russian Journal of Physical Chemistry A, 83(9), 1602-1608.
https://doi.org/10.1134/S0036024409090337
Čolović MB, Krstić DZ, Krinulović K, Momić T, Savić J, Vujačić AV, Vasić VM. Na+/K+-ATPase: Activity and inhibition. in Russian Journal of Physical Chemistry A. 2009;83(9):1602-1608.
doi:10.1134/S0036024409090337 .
Čolović, Mirjana B., Krstić, Danijela Z., Krinulović, Katarina, Momić, Tatjana, Savić, Jasmina, Vujačić, Ana V., Vasić, Vesna M., "Na+/K+-ATPase: Activity and inhibition" in Russian Journal of Physical Chemistry A, 83, no. 9 (2009):1602-1608,
https://doi.org/10.1134/S0036024409090337 . .
3
6
6

Detection of toxic metal ions in water based on Na+/K+-ATPase activity measurement

Krinulović, Katarina; Vasić, Vesna M.; Krstić, Danijela Z.

(2005)

TY  - CONF
AU  - Krinulović, Katarina
AU  - Vasić, Vesna M.
AU  - Krstić, Danijela Z.
PY  - 2005
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/6585
AB  - The possibility of using enzyme Na+/K+-ATPase as a biological component of sensing system for detection of toxic metal ions (Hg2+, Pb2+ and Cd2+) in water samples has been studied. The method is based on the spectrophotometric determination of inorganic orthophosphate (P) that serves as a measure of the enzymatic activity in the presence of considered metal ions. The concentration of Pi, liberated by enzyme catalysed hydrolysis of adenosinetriphosphate (ATP), was followed spectrophotometrically, by single exposure to analytes or in the mixture. Hg2+, Pb2+ and Cd2+ induced the dose-dependent inhibition of Na+/K+-ATPase activity in enzymatic mixture. Sigmoid shaped inhibition curves were obtained in all cases. Half-maximum inhibitory activities (IC50) were determined by fitting the experimental data by sigmoid function. Considering Na+/K+-ATPase high sensibility to toxic metal ions, the development of simple and quick method for preliminary detection of water contamination by metals based on enzymatic activity measurement was suggested.
T1  - Detection of toxic metal ions in water based on Na+/K+-ATPase activity measurement
SP  - B479
EP  - B484
ER  - 
@conference{
author = "Krinulović, Katarina and Vasić, Vesna M. and Krstić, Danijela Z.",
year = "2005",
abstract = "The possibility of using enzyme Na+/K+-ATPase as a biological component of sensing system for detection of toxic metal ions (Hg2+, Pb2+ and Cd2+) in water samples has been studied. The method is based on the spectrophotometric determination of inorganic orthophosphate (P) that serves as a measure of the enzymatic activity in the presence of considered metal ions. The concentration of Pi, liberated by enzyme catalysed hydrolysis of adenosinetriphosphate (ATP), was followed spectrophotometrically, by single exposure to analytes or in the mixture. Hg2+, Pb2+ and Cd2+ induced the dose-dependent inhibition of Na+/K+-ATPase activity in enzymatic mixture. Sigmoid shaped inhibition curves were obtained in all cases. Half-maximum inhibitory activities (IC50) were determined by fitting the experimental data by sigmoid function. Considering Na+/K+-ATPase high sensibility to toxic metal ions, the development of simple and quick method for preliminary detection of water contamination by metals based on enzymatic activity measurement was suggested.",
title = "Detection of toxic metal ions in water based on Na+/K+-ATPase activity measurement",
pages = "B479-B484"
}
Krinulović, K., Vasić, V. M.,& Krstić, D. Z.. (2005). Detection of toxic metal ions in water based on Na+/K+-ATPase activity measurement. , B479-B484.
Krinulović K, Vasić VM, Krstić DZ. Detection of toxic metal ions in water based on Na+/K+-ATPase activity measurement. 2005;:B479-B484..
Krinulović, Katarina, Vasić, Vesna M., Krstić, Danijela Z., "Detection of toxic metal ions in water based on Na+/K+-ATPase activity measurement" (2005):B479-B484.