TY  - JOUR
AU  - Vrbjar, Norbert
AU  - Vlkovicova, Jana
AU  - Snurikova, Denisa
AU  - Kalocayova, Barbora
AU  - Zorad, Stefan
AU  - Ćulafić, Tijana
AU  - Tepavčević, Snežana
AU  - Tothova, Lubomira
AU  - Radosinska, Dominika
AU  - Kollarova, Marta
AU  - Radosinska, Jana
PY  - 2023
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10930
AB  - The study aimed to characterize the consequences of a 15-week intake of 10% fructose on the kidney, with the focus on oxidative stress markers and properties of the Na,K-ATPase enzyme. Various antioxidants naturally occurring in common food were demonstrated to be protective against fructose-induced deterioration of kidneys. Therefore, we also aimed to observe the effect of 6-week quercetin administration (20 mg/kg/day) that was initiated following the 9-week period of higher fructose intake, by determining the concentration of sodium, potassium, creatinine, urea, and glucose in blood plasma and oxidative status directly in the renal tissue. Kinetic studies of renal Na,K-ATPase were utilized for a deeper insight into the molecular principles of expected changes in this enzyme activity under conditions of presumed fructose-induced renal injury. Fructose intake led to increase in body weight gain, plasma glucose and sodium levels, and deterioration of kidney properties, although some compensatory mechanisms were observable. Quercetin administration improved glycemic control in rats exposed to fructose overload. However, an increase in plasma creatinine, a decrease in GSH/GSSG ratio in renal tissue homogenate, and a controversial effect on renal Na,K-ATPase enzyme suggest that quercetin treatment may not be beneficial in the condition of pre-existing renal pathology.
T2  - Life
T1  - Alterations in Oxidative Stress Markers and Na,K-ATPase Enzyme Properties in Kidney after Fructose Intake and Quercetin Intervention in Rats
VL  - 13
IS  - 4
SP  - 931
DO  - 10.3390/life13040931
ER  - 

@article{
author = "Vrbjar, Norbert and Vlkovicova, Jana and Snurikova, Denisa and Kalocayova, Barbora and Zorad, Stefan and Ćulafić, Tijana and Tepavčević, Snežana and Tothova, Lubomira and Radosinska, Dominika and Kollarova, Marta and Radosinska, Jana",
year = "2023",
abstract = "The study aimed to characterize the consequences of a 15-week intake of 10% fructose on the kidney, with the focus on oxidative stress markers and properties of the Na,K-ATPase enzyme. Various antioxidants naturally occurring in common food were demonstrated to be protective against fructose-induced deterioration of kidneys. Therefore, we also aimed to observe the effect of 6-week quercetin administration (20 mg/kg/day) that was initiated following the 9-week period of higher fructose intake, by determining the concentration of sodium, potassium, creatinine, urea, and glucose in blood plasma and oxidative status directly in the renal tissue. Kinetic studies of renal Na,K-ATPase were utilized for a deeper insight into the molecular principles of expected changes in this enzyme activity under conditions of presumed fructose-induced renal injury. Fructose intake led to increase in body weight gain, plasma glucose and sodium levels, and deterioration of kidney properties, although some compensatory mechanisms were observable. Quercetin administration improved glycemic control in rats exposed to fructose overload. However, an increase in plasma creatinine, a decrease in GSH/GSSG ratio in renal tissue homogenate, and a controversial effect on renal Na,K-ATPase enzyme suggest that quercetin treatment may not be beneficial in the condition of pre-existing renal pathology.",
journal = "Life",
title = "Alterations in Oxidative Stress Markers and Na,K-ATPase Enzyme Properties in Kidney after Fructose Intake and Quercetin Intervention in Rats",
volume = "13",
number = "4",
pages = "931",
doi = "10.3390/life13040931"
}

Vrbjar, N., Vlkovicova, J., Snurikova, D., Kalocayova, B., Zorad, S., Ćulafić, T., Tepavčević, S., Tothova, L., Radosinska, D., Kollarova, M.,& Radosinska, J.. (2023). Alterations in Oxidative Stress Markers and Na,K-ATPase Enzyme Properties in Kidney after Fructose Intake and Quercetin Intervention in Rats. in Life, 13(4), 931.
https://doi.org/10.3390/life13040931

Vrbjar N, Vlkovicova J, Snurikova D, Kalocayova B, Zorad S, Ćulafić T, Tepavčević S, Tothova L, Radosinska D, Kollarova M, Radosinska J. Alterations in Oxidative Stress Markers and Na,K-ATPase Enzyme Properties in Kidney after Fructose Intake and Quercetin Intervention in Rats. in Life. 2023;13(4):931.
doi:10.3390/life13040931 .

Vrbjar, Norbert, Vlkovicova, Jana, Snurikova, Denisa, Kalocayova, Barbora, Zorad, Stefan, Ćulafić, Tijana, Tepavčević, Snežana, Tothova, Lubomira, Radosinska, Dominika, Kollarova, Marta, Radosinska, Jana, "Alterations in Oxidative Stress Markers and Na,K-ATPase Enzyme Properties in Kidney after Fructose Intake and Quercetin Intervention in Rats" in Life, 13, no. 4 (2023):931,
https://doi.org/10.3390/life13040931 . .