TY  - JOUR
AU  - Mladenovic, Dusan
AU  - Krstić, Danijela Z.
AU  - Čolović, Mirjana B.
AU  - Radosavljevic, Tatjana
AU  - Rašić-Marković, Aleksandra
AU  - Hrnčić, Dragan
AU  - Macut, Djuro
AU  - Stanojlović, Olivera
PY  - 2012
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/4696
AB  - Thioacetamide (TAA) exerts hepatotoxic, neurotoxic and carcinogenic effects. The aim of our study was to investigate the effects of TAA on lipid peroxidation and catalase activity in various rat brain regions. Male Wistar rats were divided into following groups: 1. control, saline-treated; 2. thioacetamide-treated groups, TAA(300) (300 mg/kg), TAA(600) (600 mg/kg) and TAA(900) (900 mg/kg). Daily dose of TAA (300 mg/kg) was administered intraperitoneally once (TAA(300)), twice (TAA(600)) and three times (TAA(900)) in consecutive days. Brain samples were collected 24 h after the last dose of TAA and malondialdehyde (MDA) level and catalase activity were determined in cortex, brainstem and hippocampus. MDA level was significantly increased while catalase activity was significantly lower in all brain regions in TAA(900) group in comparison with control group. In TAA(600) MDA level was increased in the brainstem and cortex when compared to control (p LT 0.01). The same dose of TAA(600) mg/kg induced a significant decline in catalase activity in the brainstem and cortex and an increase in its activity in the hippocampus when compared to control (p LT 0.01). In TAA(300) an increase in MDA level was evident only in the brainstem. Catalase activity was significantly higher in the cortex and hippocampus in TAA(300) group in comparison with control (p LT 0.01). Based on these results, it may be concluded that various rat brain regions have different sensitivity to TAA-induced lipid peroxidation with hippocampus being less sensitive than cerebral cortex and brainstem.
T2  - Medicinal Chemistry
T1  - Different Sensitivity of Various Brain Structures to Thioacetamide-Induced Lipid Peroxidation
VL  - 8
IS  - 1
SP  - 52
EP  - 58
DO  - 10.2174/157340612799278603
ER  - 

@article{
author = "Mladenovic, Dusan and Krstić, Danijela Z. and Čolović, Mirjana B. and Radosavljevic, Tatjana and Rašić-Marković, Aleksandra and Hrnčić, Dragan and Macut, Djuro and Stanojlović, Olivera",
year = "2012",
abstract = "Thioacetamide (TAA) exerts hepatotoxic, neurotoxic and carcinogenic effects. The aim of our study was to investigate the effects of TAA on lipid peroxidation and catalase activity in various rat brain regions. Male Wistar rats were divided into following groups: 1. control, saline-treated; 2. thioacetamide-treated groups, TAA(300) (300 mg/kg), TAA(600) (600 mg/kg) and TAA(900) (900 mg/kg). Daily dose of TAA (300 mg/kg) was administered intraperitoneally once (TAA(300)), twice (TAA(600)) and three times (TAA(900)) in consecutive days. Brain samples were collected 24 h after the last dose of TAA and malondialdehyde (MDA) level and catalase activity were determined in cortex, brainstem and hippocampus. MDA level was significantly increased while catalase activity was significantly lower in all brain regions in TAA(900) group in comparison with control group. In TAA(600) MDA level was increased in the brainstem and cortex when compared to control (p LT 0.01). The same dose of TAA(600) mg/kg induced a significant decline in catalase activity in the brainstem and cortex and an increase in its activity in the hippocampus when compared to control (p LT 0.01). In TAA(300) an increase in MDA level was evident only in the brainstem. Catalase activity was significantly higher in the cortex and hippocampus in TAA(300) group in comparison with control (p LT 0.01). Based on these results, it may be concluded that various rat brain regions have different sensitivity to TAA-induced lipid peroxidation with hippocampus being less sensitive than cerebral cortex and brainstem.",
journal = "Medicinal Chemistry",
title = "Different Sensitivity of Various Brain Structures to Thioacetamide-Induced Lipid Peroxidation",
volume = "8",
number = "1",
pages = "52-58",
doi = "10.2174/157340612799278603"
}

Mladenovic, D., Krstić, D. Z., Čolović, M. B., Radosavljevic, T., Rašić-Marković, A., Hrnčić, D., Macut, D.,& Stanojlović, O.. (2012). Different Sensitivity of Various Brain Structures to Thioacetamide-Induced Lipid Peroxidation. in Medicinal Chemistry, 8(1), 52-58.
https://doi.org/10.2174/157340612799278603

Mladenovic D, Krstić DZ, Čolović MB, Radosavljevic T, Rašić-Marković A, Hrnčić D, Macut D, Stanojlović O. Different Sensitivity of Various Brain Structures to Thioacetamide-Induced Lipid Peroxidation. in Medicinal Chemistry. 2012;8(1):52-58.
doi:10.2174/157340612799278603 .

Mladenovic, Dusan, Krstić, Danijela Z., Čolović, Mirjana B., Radosavljevic, Tatjana, Rašić-Marković, Aleksandra, Hrnčić, Dragan, Macut, Djuro, Stanojlović, Olivera, "Different Sensitivity of Various Brain Structures to Thioacetamide-Induced Lipid Peroxidation" in Medicinal Chemistry, 8, no. 1 (2012):52-58,
https://doi.org/10.2174/157340612799278603 . .

TY  - JOUR
AU  - Rašić-Marković, Aleksandra
AU  - Đurić, Dragan M.
AU  - Hrnčić, Dragan
AU  - Lončar-Stevanović, Helena
AU  - Vucevic, Danijela
AU  - Mladenovic, Dusan
AU  - Brkić, Predrag
AU  - Djuro, Macut
AU  - Stanojević, Ivana
AU  - Stanojlović, Olivera
PY  - 2009
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/2729
AB  - The effects of ethanol on epilepsy are very complex. Ethanol can have depressant as well as excitatory effect on different animal models of epilepsy. Systemic administration of homocysteine can trigger seizures. The aim of the present study was to examine the changes of total spectral power density after ethanol alone and together with homocysteine thiolactone in adult rats. Adult male Wistar rats were divided into following groups: I. saline-injected, (control) C; 2. D, L-homocysteine thiolactone, H (8 mmol/kg); 3. ethanol, E (E(0.5), 0.5 g/kg; E(1), 1 g/kg; E(2), 2 g/kg) and 4. E (E(0.5), E(1), and E(2)) 30 min prior to H, EH (E(0.5)H, E(1)H and E(2)H). For EEG recordings three gold-plated screws were implanted into the skull. Our results demonstrate that ethanol, when applied alone, increased total EEG spectral power density of adult rats with a marked spectrum shift toward low frequency waves. In EH groups, increasing doses of ethanol exhibited a dose-dependent effect upon spectral power density. Ethanol increased EEG spectral power density in E(0.5)H and E(1)H group, comparing to the H group (p GT 0.05), the maximal increase was recorded with the lowest ethanol dose applied. The highest dose of ethanol (E(2)H) significantly decreased total power spectra density, comparing to the H group. We can conclude that high doses of ethanol depressed marked increase in EEG power spectrum induced by D,L-homocysteine thiolactone.
T2  - General Physiology and Biophysics
T1  - High dose of ethanol decreases total spectral power density in seizures induced by D,L-homocysteine thiolactone in adult rats
VL  - 28
IS  - SI
SP  - 25
EP  - 32
UR  - https://hdl.handle.net/21.15107/rcub_vinar_2729
ER  - 

@article{
author = "Rašić-Marković, Aleksandra and Đurić, Dragan M. and Hrnčić, Dragan and Lončar-Stevanović, Helena and Vucevic, Danijela and Mladenovic, Dusan and Brkić, Predrag and Djuro, Macut and Stanojević, Ivana and Stanojlović, Olivera",
year = "2009",
abstract = "The effects of ethanol on epilepsy are very complex. Ethanol can have depressant as well as excitatory effect on different animal models of epilepsy. Systemic administration of homocysteine can trigger seizures. The aim of the present study was to examine the changes of total spectral power density after ethanol alone and together with homocysteine thiolactone in adult rats. Adult male Wistar rats were divided into following groups: I. saline-injected, (control) C; 2. D, L-homocysteine thiolactone, H (8 mmol/kg); 3. ethanol, E (E(0.5), 0.5 g/kg; E(1), 1 g/kg; E(2), 2 g/kg) and 4. E (E(0.5), E(1), and E(2)) 30 min prior to H, EH (E(0.5)H, E(1)H and E(2)H). For EEG recordings three gold-plated screws were implanted into the skull. Our results demonstrate that ethanol, when applied alone, increased total EEG spectral power density of adult rats with a marked spectrum shift toward low frequency waves. In EH groups, increasing doses of ethanol exhibited a dose-dependent effect upon spectral power density. Ethanol increased EEG spectral power density in E(0.5)H and E(1)H group, comparing to the H group (p GT 0.05), the maximal increase was recorded with the lowest ethanol dose applied. The highest dose of ethanol (E(2)H) significantly decreased total power spectra density, comparing to the H group. We can conclude that high doses of ethanol depressed marked increase in EEG power spectrum induced by D,L-homocysteine thiolactone.",
journal = "General Physiology and Biophysics",
title = "High dose of ethanol decreases total spectral power density in seizures induced by D,L-homocysteine thiolactone in adult rats",
volume = "28",
number = "SI",
pages = "25-32",
url = "https://hdl.handle.net/21.15107/rcub_vinar_2729"
}

Rašić-Marković, A., Đurić, D. M., Hrnčić, D., Lončar-Stevanović, H., Vucevic, D., Mladenovic, D., Brkić, P., Djuro, M., Stanojević, I.,& Stanojlović, O.. (2009). High dose of ethanol decreases total spectral power density in seizures induced by D,L-homocysteine thiolactone in adult rats. in General Physiology and Biophysics, 28(SI), 25-32.
https://hdl.handle.net/21.15107/rcub_vinar_2729

Rašić-Marković A, Đurić DM, Hrnčić D, Lončar-Stevanović H, Vucevic D, Mladenovic D, Brkić P, Djuro M, Stanojević I, Stanojlović O. High dose of ethanol decreases total spectral power density in seizures induced by D,L-homocysteine thiolactone in adult rats. in General Physiology and Biophysics. 2009;28(SI):25-32.
https://hdl.handle.net/21.15107/rcub_vinar_2729 .

Rašić-Marković, Aleksandra, Đurić, Dragan M., Hrnčić, Dragan, Lončar-Stevanović, Helena, Vucevic, Danijela, Mladenovic, Dusan, Brkić, Predrag, Djuro, Macut, Stanojević, Ivana, Stanojlović, Olivera, "High dose of ethanol decreases total spectral power density in seizures induced by D,L-homocysteine thiolactone in adult rats" in General Physiology and Biophysics, 28, no. SI (2009):25-32,
https://hdl.handle.net/21.15107/rcub_vinar_2729 .