Lazarević-Macanović, Mirjana V.

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  • Lazarević-Macanović, Mirjana V. (3)
  • Lazarević-Macanović, Mirjana (1)
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Author's Bibliography

Voxel model of a rabbit: assessment of absorbed doses in organs after CT examination performed by two different protocols

Mitrović, Marko; Ciraj-Bjelac, Olivera; Jovanović, Z.; Krstić, N.; Nikezić, Dragoslav; Krstić, D.; Živković, M.; Lazarević-Macanović, Mirjana

(2021)

TY  - JOUR
AU  - Mitrović, Marko
AU  - Ciraj-Bjelac, Olivera
AU  - Jovanović, Z.
AU  - Krstić, N.
AU  - Nikezić, Dragoslav
AU  - Krstić, D.
AU  - Živković, M.
AU  - Lazarević-Macanović, Mirjana
PY  - 2021
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/9913
AB  - The objective of this work was to assess absorbed doses in organs and tissues of a rabbit, following computed tomography (CT) examinations, using a dedicated 3D voxel model. Absorbed doses in relevant organs were calculated using the MCNP5 Monte Carlo software. Calculations were perfomed for two standard CT protocols, using tube voltages of 110 kVp and 130 kVp. Absorbed doses were calculated in 11 organs and tissues, i.e., skin, bones, brain, muscles, heart, lungs, liver, spleen, kidney, testicles, and fat tissue. The doses ranged from 15.3 to 28.3 mGy, and from 40.2 to 74.3 mGy, in the two investigated protocols. The organs that received the highest dose were bones and kidneys. In contrast, brain and spleen were organs that received the smallest doses. Doses in organs which are stretched along the body did not change significantly with distance. On the other hand, doses in organs which are localized in the body showed maximums and minimums. Using the voxel model, it is possible to calculate the dose distribution in the rabbit’s body after CT scans, and study the potential biological effects of CT doses in certain organs. The voxel model presented in this work can be used to calculated doses in all radiation experiments in which rabbits are used as experimental animals.
T2  - Radiation and Environmental Biophysics
T1  - Voxel model of a rabbit: assessment of absorbed doses in organs after CT examination performed by two different protocols
VL  - 60
IS  - 4
SP  - 631
EP  - 638
DO  - 10.1007/s00411-021-00941-7
ER  - 
@article{
author = "Mitrović, Marko and Ciraj-Bjelac, Olivera and Jovanović, Z. and Krstić, N. and Nikezić, Dragoslav and Krstić, D. and Živković, M. and Lazarević-Macanović, Mirjana",
year = "2021",
abstract = "The objective of this work was to assess absorbed doses in organs and tissues of a rabbit, following computed tomography (CT) examinations, using a dedicated 3D voxel model. Absorbed doses in relevant organs were calculated using the MCNP5 Monte Carlo software. Calculations were perfomed for two standard CT protocols, using tube voltages of 110 kVp and 130 kVp. Absorbed doses were calculated in 11 organs and tissues, i.e., skin, bones, brain, muscles, heart, lungs, liver, spleen, kidney, testicles, and fat tissue. The doses ranged from 15.3 to 28.3 mGy, and from 40.2 to 74.3 mGy, in the two investigated protocols. The organs that received the highest dose were bones and kidneys. In contrast, brain and spleen were organs that received the smallest doses. Doses in organs which are stretched along the body did not change significantly with distance. On the other hand, doses in organs which are localized in the body showed maximums and minimums. Using the voxel model, it is possible to calculate the dose distribution in the rabbit’s body after CT scans, and study the potential biological effects of CT doses in certain organs. The voxel model presented in this work can be used to calculated doses in all radiation experiments in which rabbits are used as experimental animals.",
journal = "Radiation and Environmental Biophysics",
title = "Voxel model of a rabbit: assessment of absorbed doses in organs after CT examination performed by two different protocols",
volume = "60",
number = "4",
pages = "631-638",
doi = "10.1007/s00411-021-00941-7"
}
Mitrović, M., Ciraj-Bjelac, O., Jovanović, Z., Krstić, N., Nikezić, D., Krstić, D., Živković, M.,& Lazarević-Macanović, M.. (2021). Voxel model of a rabbit: assessment of absorbed doses in organs after CT examination performed by two different protocols. in Radiation and Environmental Biophysics, 60(4), 631-638.
https://doi.org/10.1007/s00411-021-00941-7
Mitrović M, Ciraj-Bjelac O, Jovanović Z, Krstić N, Nikezić D, Krstić D, Živković M, Lazarević-Macanović M. Voxel model of a rabbit: assessment of absorbed doses in organs after CT examination performed by two different protocols. in Radiation and Environmental Biophysics. 2021;60(4):631-638.
doi:10.1007/s00411-021-00941-7 .
Mitrović, Marko, Ciraj-Bjelac, Olivera, Jovanović, Z., Krstić, N., Nikezić, Dragoslav, Krstić, D., Živković, M., Lazarević-Macanović, Mirjana, "Voxel model of a rabbit: assessment of absorbed doses in organs after CT examination performed by two different protocols" in Radiation and Environmental Biophysics, 60, no. 4 (2021):631-638,
https://doi.org/10.1007/s00411-021-00941-7 . .
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Influence of absorbed radiation dose following computed tomography on the antioxidative status in rabbit testicles

Mitrović, Marko B.; Tatalović, Nikola R.; Nikolić-Kokić, Aleksandra L.; Ciraj-Bjelac, Olivera; Krstić, Nikola E.; Oreščanin-Dušić, Zorana S.; Krstić, Dragana Ž.; Jovanović, Zoran M.; Blagojević, Duško P.; Lazarević-Macanović, Mirjana V.

(2018)

TY  - JOUR
AU  - Mitrović, Marko B.
AU  - Tatalović, Nikola R.
AU  - Nikolić-Kokić, Aleksandra L.
AU  - Ciraj-Bjelac, Olivera
AU  - Krstić, Nikola E.
AU  - Oreščanin-Dušić, Zorana S.
AU  - Krstić, Dragana Ž.
AU  - Jovanović, Zoran M.
AU  - Blagojević, Duško P.
AU  - Lazarević-Macanović, Mirjana V.
PY  - 2018
UR  - http://www.doiserbia.nb.rs/Article.aspx?ID=0354-46641800029M
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/8001
AB  - In recent years, computed tomography (CT) has become very common in veterinary medicine. It is well known that testicles are organs with high radiosensitivity and their function can be impaired even after exposure to low radiation doses. In this work, we calculated the absorbed radiation doses after CT was performed with different voltage/current levels and correlated it with the activity of antioxidant enzymes in rabbit testicles. Two hours after CT, the activities of catalase (CAT) and glutathione peroxidase (GSH-Px) were increased in the testicles of animals that received an absorbed dose of 29.2 mGy. The same changes, along with elevated glutathione reductase (GR) activity, were observed after 7 days in animals that received the highest absorbed dose (46.3 mGy). It would appear that absorbed doses above 27.8 mGy provoked the antioxidant reaction but the time scale of the reaction was dose-dependent. Examination of the obtained results revealed that the main denominator of CT influence was a higher current. Our results suggest that CT influences the antioxidant status in rabbit testicles. The changes in antioxidant enzyme activities were dose- and time-dependent and influenced by the applied current. © 2018 by the Serbian Biological Society.
T2  - Archives of Biological Sciences
T1  - Influence of absorbed radiation dose following computed tomography on the antioxidative status in rabbit testicles
VL  - 70
IS  - 4
SP  - 675
EP  - 680
DO  - 10.2298/ABS180413029M
ER  - 
@article{
author = "Mitrović, Marko B. and Tatalović, Nikola R. and Nikolić-Kokić, Aleksandra L. and Ciraj-Bjelac, Olivera and Krstić, Nikola E. and Oreščanin-Dušić, Zorana S. and Krstić, Dragana Ž. and Jovanović, Zoran M. and Blagojević, Duško P. and Lazarević-Macanović, Mirjana V.",
year = "2018",
abstract = "In recent years, computed tomography (CT) has become very common in veterinary medicine. It is well known that testicles are organs with high radiosensitivity and their function can be impaired even after exposure to low radiation doses. In this work, we calculated the absorbed radiation doses after CT was performed with different voltage/current levels and correlated it with the activity of antioxidant enzymes in rabbit testicles. Two hours after CT, the activities of catalase (CAT) and glutathione peroxidase (GSH-Px) were increased in the testicles of animals that received an absorbed dose of 29.2 mGy. The same changes, along with elevated glutathione reductase (GR) activity, were observed after 7 days in animals that received the highest absorbed dose (46.3 mGy). It would appear that absorbed doses above 27.8 mGy provoked the antioxidant reaction but the time scale of the reaction was dose-dependent. Examination of the obtained results revealed that the main denominator of CT influence was a higher current. Our results suggest that CT influences the antioxidant status in rabbit testicles. The changes in antioxidant enzyme activities were dose- and time-dependent and influenced by the applied current. © 2018 by the Serbian Biological Society.",
journal = "Archives of Biological Sciences",
title = "Influence of absorbed radiation dose following computed tomography on the antioxidative status in rabbit testicles",
volume = "70",
number = "4",
pages = "675-680",
doi = "10.2298/ABS180413029M"
}
Mitrović, M. B., Tatalović, N. R., Nikolić-Kokić, A. L., Ciraj-Bjelac, O., Krstić, N. E., Oreščanin-Dušić, Z. S., Krstić, D. Ž., Jovanović, Z. M., Blagojević, D. P.,& Lazarević-Macanović, M. V.. (2018). Influence of absorbed radiation dose following computed tomography on the antioxidative status in rabbit testicles. in Archives of Biological Sciences, 70(4), 675-680.
https://doi.org/10.2298/ABS180413029M
Mitrović MB, Tatalović NR, Nikolić-Kokić AL, Ciraj-Bjelac O, Krstić NE, Oreščanin-Dušić ZS, Krstić DŽ, Jovanović ZM, Blagojević DP, Lazarević-Macanović MV. Influence of absorbed radiation dose following computed tomography on the antioxidative status in rabbit testicles. in Archives of Biological Sciences. 2018;70(4):675-680.
doi:10.2298/ABS180413029M .
Mitrović, Marko B., Tatalović, Nikola R., Nikolić-Kokić, Aleksandra L., Ciraj-Bjelac, Olivera, Krstić, Nikola E., Oreščanin-Dušić, Zorana S., Krstić, Dragana Ž., Jovanović, Zoran M., Blagojević, Duško P., Lazarević-Macanović, Mirjana V., "Influence of absorbed radiation dose following computed tomography on the antioxidative status in rabbit testicles" in Archives of Biological Sciences, 70, no. 4 (2018):675-680,
https://doi.org/10.2298/ABS180413029M . .
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Influence of Radiation Dose in Computed Tomography on Antioxidant Enzyme Activity in Rabbit Erythrocytes

Mitrović, Marko B.; Ciraj-Bjelac, Olivera; Oreščanin-Dušić, Zorana S.; Blagojević, Duško P.; Nikolić-Kokić, Aleksandra L.; Tatalović, Nikola R.; Krstić, Nikola E.; Lazarević-Macanović, Mirjana V.

(2017)

TY  - JOUR
AU  - Mitrović, Marko B.
AU  - Ciraj-Bjelac, Olivera
AU  - Oreščanin-Dušić, Zorana S.
AU  - Blagojević, Duško P.
AU  - Nikolić-Kokić, Aleksandra L.
AU  - Tatalović, Nikola R.
AU  - Krstić, Nikola E.
AU  - Lazarević-Macanović, Mirjana V.
PY  - 2017
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/1934
AB  - The objective of this study was to assess the radiation dose in computed tomography examinations of rabbits using different examination protocols and to correlate these values with the activity of antioxidant enzymes in their red blood cells following irradiation. The presented results revealed that a single, routine computed tomography scan exposure led to a different response of the activity of antioxidant enzymes in red blood cells regarding both dose and time. The results indicate that there is a dose threshold that is about 25 mGy. Doses below that level do not produce any significant changes in the level of antioxidant enzymes activity. On the other hand, the level just above that threshold had a significant impact on the antioxidant defence, but in a relatively short time period (2 hours after exposure), compared to the higher dose that requires a longer adaptive period.
T2  - Nuclear technology and radiation protection
T1  - Influence of Radiation Dose in Computed Tomography on Antioxidant Enzyme Activity in Rabbit Erythrocytes
VL  - 32
IS  - 4
SP  - 342
EP  - 349
DO  - 10.2298/NTRP1704342M
ER  - 
@article{
author = "Mitrović, Marko B. and Ciraj-Bjelac, Olivera and Oreščanin-Dušić, Zorana S. and Blagojević, Duško P. and Nikolić-Kokić, Aleksandra L. and Tatalović, Nikola R. and Krstić, Nikola E. and Lazarević-Macanović, Mirjana V.",
year = "2017",
abstract = "The objective of this study was to assess the radiation dose in computed tomography examinations of rabbits using different examination protocols and to correlate these values with the activity of antioxidant enzymes in their red blood cells following irradiation. The presented results revealed that a single, routine computed tomography scan exposure led to a different response of the activity of antioxidant enzymes in red blood cells regarding both dose and time. The results indicate that there is a dose threshold that is about 25 mGy. Doses below that level do not produce any significant changes in the level of antioxidant enzymes activity. On the other hand, the level just above that threshold had a significant impact on the antioxidant defence, but in a relatively short time period (2 hours after exposure), compared to the higher dose that requires a longer adaptive period.",
journal = "Nuclear technology and radiation protection",
title = "Influence of Radiation Dose in Computed Tomography on Antioxidant Enzyme Activity in Rabbit Erythrocytes",
volume = "32",
number = "4",
pages = "342-349",
doi = "10.2298/NTRP1704342M"
}
Mitrović, M. B., Ciraj-Bjelac, O., Oreščanin-Dušić, Z. S., Blagojević, D. P., Nikolić-Kokić, A. L., Tatalović, N. R., Krstić, N. E.,& Lazarević-Macanović, M. V.. (2017). Influence of Radiation Dose in Computed Tomography on Antioxidant Enzyme Activity in Rabbit Erythrocytes. in Nuclear technology and radiation protection, 32(4), 342-349.
https://doi.org/10.2298/NTRP1704342M
Mitrović MB, Ciraj-Bjelac O, Oreščanin-Dušić ZS, Blagojević DP, Nikolić-Kokić AL, Tatalović NR, Krstić NE, Lazarević-Macanović MV. Influence of Radiation Dose in Computed Tomography on Antioxidant Enzyme Activity in Rabbit Erythrocytes. in Nuclear technology and radiation protection. 2017;32(4):342-349.
doi:10.2298/NTRP1704342M .
Mitrović, Marko B., Ciraj-Bjelac, Olivera, Oreščanin-Dušić, Zorana S., Blagojević, Duško P., Nikolić-Kokić, Aleksandra L., Tatalović, Nikola R., Krstić, Nikola E., Lazarević-Macanović, Mirjana V., "Influence of Radiation Dose in Computed Tomography on Antioxidant Enzyme Activity in Rabbit Erythrocytes" in Nuclear technology and radiation protection, 32, no. 4 (2017):342-349,
https://doi.org/10.2298/NTRP1704342M . .
1
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Comparative study of Cs-137 distribution in broilers and pheasants and possibilities for protection

Mitrovic, Branislava M.; Vitorovic, Gordana; Vicentijevic, Mihajlo; Vitorovic, Dusko; Pantelić, Gordana K.; Lazarević-Macanović, Mirjana V.

(2012)

TY  - JOUR
AU  - Mitrovic, Branislava M.
AU  - Vitorovic, Gordana
AU  - Vicentijevic, Mihajlo
AU  - Vitorovic, Dusko
AU  - Pantelić, Gordana K.
AU  - Lazarević-Macanović, Mirjana V.
PY  - 2012
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/4705
AB  - The aim of the present study was to investigate distribution of Cs-137 in leg and breast meat of broilers and pheasants following single alimentary contamination and administration of two protectors (AFCF and clinoptilolite). The birds were administered a single dose of (CsCl)-Cs-137, with an activity of 750 Bq. Protectors were given via gastric tube or mixed in the forage pellets. AFCF given via gastric tube decreased the Cs-137 concentration by a factor of 7.8 in broilers leg meat and 7.4 in broilers breast meat. When AFCF was mixed in pellets, the Cs-137 concentration was 19.5 times lower in broilers leg meat and 22.1 times lower in broilers breast meat, than in the control group. In pheasants, AFCF administered via gastric tube decreased the Cs-137 concentration by a factor of 12.4 in leg meat and by a factor of 13.7 in breast meat, respectively. In group 4, where pheasants were administered AFCF mixed in pellets, the Cs-137 concentration was 3.7 times lower in leg and breast meat, than in the control group. For comparison, clinoptilolite administered via gastric tube decreased the Cs-137 concentration 1.8 times in broilers leg meat and 2.0 times in breast meat, compared to the control group. In pheasants, Cs-137 concentration was 2.9 times lower in leg meat and 2.6 times lower in breast meat. Clinoptilolite mixed in the feed had relatively low efficiency of protection in broilers (Cs-137 concentration was 1.4 times lower in leg meat and 1.6 lower in breast meat). A similar trend was observed in pheasants (Cs-137 concentration was 1.6 lower in leg and breast meat).
T2  - Radiation and Environmental Biophysics
T1  - Comparative study of Cs-137 distribution in broilers and pheasants and possibilities for protection
VL  - 51
IS  - 1
SP  - 79
EP  - 84
DO  - 10.1007/s00411-011-0391-8
ER  - 
@article{
author = "Mitrovic, Branislava M. and Vitorovic, Gordana and Vicentijevic, Mihajlo and Vitorovic, Dusko and Pantelić, Gordana K. and Lazarević-Macanović, Mirjana V.",
year = "2012",
abstract = "The aim of the present study was to investigate distribution of Cs-137 in leg and breast meat of broilers and pheasants following single alimentary contamination and administration of two protectors (AFCF and clinoptilolite). The birds were administered a single dose of (CsCl)-Cs-137, with an activity of 750 Bq. Protectors were given via gastric tube or mixed in the forage pellets. AFCF given via gastric tube decreased the Cs-137 concentration by a factor of 7.8 in broilers leg meat and 7.4 in broilers breast meat. When AFCF was mixed in pellets, the Cs-137 concentration was 19.5 times lower in broilers leg meat and 22.1 times lower in broilers breast meat, than in the control group. In pheasants, AFCF administered via gastric tube decreased the Cs-137 concentration by a factor of 12.4 in leg meat and by a factor of 13.7 in breast meat, respectively. In group 4, where pheasants were administered AFCF mixed in pellets, the Cs-137 concentration was 3.7 times lower in leg and breast meat, than in the control group. For comparison, clinoptilolite administered via gastric tube decreased the Cs-137 concentration 1.8 times in broilers leg meat and 2.0 times in breast meat, compared to the control group. In pheasants, Cs-137 concentration was 2.9 times lower in leg meat and 2.6 times lower in breast meat. Clinoptilolite mixed in the feed had relatively low efficiency of protection in broilers (Cs-137 concentration was 1.4 times lower in leg meat and 1.6 lower in breast meat). A similar trend was observed in pheasants (Cs-137 concentration was 1.6 lower in leg and breast meat).",
journal = "Radiation and Environmental Biophysics",
title = "Comparative study of Cs-137 distribution in broilers and pheasants and possibilities for protection",
volume = "51",
number = "1",
pages = "79-84",
doi = "10.1007/s00411-011-0391-8"
}
Mitrovic, B. M., Vitorovic, G., Vicentijevic, M., Vitorovic, D., Pantelić, G. K.,& Lazarević-Macanović, M. V.. (2012). Comparative study of Cs-137 distribution in broilers and pheasants and possibilities for protection. in Radiation and Environmental Biophysics, 51(1), 79-84.
https://doi.org/10.1007/s00411-011-0391-8
Mitrovic BM, Vitorovic G, Vicentijevic M, Vitorovic D, Pantelić GK, Lazarević-Macanović MV. Comparative study of Cs-137 distribution in broilers and pheasants and possibilities for protection. in Radiation and Environmental Biophysics. 2012;51(1):79-84.
doi:10.1007/s00411-011-0391-8 .
Mitrovic, Branislava M., Vitorovic, Gordana, Vicentijevic, Mihajlo, Vitorovic, Dusko, Pantelić, Gordana K., Lazarević-Macanović, Mirjana V., "Comparative study of Cs-137 distribution in broilers and pheasants and possibilities for protection" in Radiation and Environmental Biophysics, 51, no. 1 (2012):79-84,
https://doi.org/10.1007/s00411-011-0391-8 . .
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