TY  - CONF
AU  - Nikolić, Ljubiša
AU  - Najman, Stevo
AU  - Petrović, Đorđe
AU  - Urošević, Maja
AU  - Nikolić, Vesna
AU  - Cakić, Suzana
PY  - 2022
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/11667
AB  - Poly(N-isopropylmethacrylamide) has significant potential for designing thermosensitive new materials. It is similar with well-known poly(N-isopropylacrylamide) hydrogels. The influence of the α-methylation on the each monomer unit in the main chain exhibits weaker intermolecular interactions between the amide group. The method of thermally-initiated free radical polymerization was applied to synthesize a series of poly(N-isopropylmethacrylamide) hydrogels with different cross-linker amount. The micrographs, obtained by the scanning electron microscopy method, indicated a semi-homogeneous crosslinked network of these hydrogels which can be classified as macroporous. The swelling behavior at room temperature of these negatively thermosensitive hydrogel exhibit a little higher swelling degree in acidic media (at pH 2.0 swelling degree was about 21) in relation to the weakly basic media (at pH 7.4 swelling degree was about 18). The poly(N-isopropylmethacrylamide) hydrogel topology showed much free space within the crosslinked polymer chains in the swollen state and they could be use as absorbers of water, diluents, dissolvent, solutions, or as carriers for active substances.
PB  - University in Banjaluka : Faculty of Technology
C3  - 14th Conference of chemists, technologists and environmentalists of Republic of Srpska : the book of abstracts; Oct 21-22, Banja Luka, Republic of Srpska
T1  - The influence of poly(N-isopropylmethacrylamide) hydrogels crosslinking on their swelling capacity
SP  - 71
UR  - https://hdl.handle.net/21.15107/rcub_vinar_11667
ER  - 

@conference{
author = "Nikolić, Ljubiša and Najman, Stevo and Petrović, Đorđe and Urošević, Maja and Nikolić, Vesna and Cakić, Suzana",
year = "2022",
abstract = "Poly(N-isopropylmethacrylamide) has significant potential for designing thermosensitive new materials. It is similar with well-known poly(N-isopropylacrylamide) hydrogels. The influence of the α-methylation on the each monomer unit in the main chain exhibits weaker intermolecular interactions between the amide group. The method of thermally-initiated free radical polymerization was applied to synthesize a series of poly(N-isopropylmethacrylamide) hydrogels with different cross-linker amount. The micrographs, obtained by the scanning electron microscopy method, indicated a semi-homogeneous crosslinked network of these hydrogels which can be classified as macroporous. The swelling behavior at room temperature of these negatively thermosensitive hydrogel exhibit a little higher swelling degree in acidic media (at pH 2.0 swelling degree was about 21) in relation to the weakly basic media (at pH 7.4 swelling degree was about 18). The poly(N-isopropylmethacrylamide) hydrogel topology showed much free space within the crosslinked polymer chains in the swollen state and they could be use as absorbers of water, diluents, dissolvent, solutions, or as carriers for active substances.",
publisher = "University in Banjaluka : Faculty of Technology",
journal = "14th Conference of chemists, technologists and environmentalists of Republic of Srpska : the book of abstracts; Oct 21-22, Banja Luka, Republic of Srpska",
title = "The influence of poly(N-isopropylmethacrylamide) hydrogels crosslinking on their swelling capacity",
pages = "71",
url = "https://hdl.handle.net/21.15107/rcub_vinar_11667"
}

Nikolić, L., Najman, S., Petrović, Đ., Urošević, M., Nikolić, V.,& Cakić, S.. (2022). The influence of poly(N-isopropylmethacrylamide) hydrogels crosslinking on their swelling capacity. in 14th Conference of chemists, technologists and environmentalists of Republic of Srpska : the book of abstracts; Oct 21-22, Banja Luka, Republic of Srpska
University in Banjaluka : Faculty of Technology., 71.
https://hdl.handle.net/21.15107/rcub_vinar_11667

Nikolić L, Najman S, Petrović Đ, Urošević M, Nikolić V, Cakić S. The influence of poly(N-isopropylmethacrylamide) hydrogels crosslinking on their swelling capacity. in 14th Conference of chemists, technologists and environmentalists of Republic of Srpska : the book of abstracts; Oct 21-22, Banja Luka, Republic of Srpska. 2022;:71.
https://hdl.handle.net/21.15107/rcub_vinar_11667 .

Nikolić, Ljubiša, Najman, Stevo, Petrović, Đorđe, Urošević, Maja, Nikolić, Vesna, Cakić, Suzana, "The influence of poly(N-isopropylmethacrylamide) hydrogels crosslinking on their swelling capacity" in 14th Conference of chemists, technologists and environmentalists of Republic of Srpska : the book of abstracts; Oct 21-22, Banja Luka, Republic of Srpska (2022):71,
https://hdl.handle.net/21.15107/rcub_vinar_11667 .

TY  - JOUR
AU  - Ilić-Stojanović, Snežana
AU  - Urošević, Maja
AU  - Nikolić, Ljubiša
AU  - Petrović, Đorđe
AU  - Stanojević, Jelena
AU  - Najman, Stevo
AU  - Nikolić, Vesna
PY  - 2020
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/9033
AB  - Poly(N-isopropylmethacrylamide) (p(NiPMAm)) is one of the lesser known homopolymers that has significant potential for designing new “intelligent” materials. The aims of this work were the synthesis a series of cross-linked p(NiPMAm) hydrogels by the free radical polymerization method and the application of gamma-ray radiation for additional cross-linking. The synthesized p(NiPMAm) hydrogels were structurally characterized by Fourier transform infrared spectroscopy (FTIR) and scanning electron microscopy (SEM). The amount of unreacted monomers was analyzed using high pressure liquid chromatography (HPLC) to evaluate conversion of monomers into polymers. The swelling behavior was monitored in dependence of pH and temperature changes. The previous aim of gamma-ray radiation was the further the cross-linkage of the obtained hydrogel sample in the gelatinous, paste-like state, but the gamma-ray radiation caused decomposition. After absorbing irradiation doses, they transformed into the liquid phase. The results obtained by the gel permeation chromatography (GPC) method indicated that only oligomers and monomers were present in the irradiated liquid material, without molecules with a higher average molar mass, i.e., that the decomposition of the hydrogels occurred. Additionally, the irradiated liquid material was analyzed using the static headspace gas chromatography mass spectrometry (HSS-GC/MS) and gas chromatography/flame ionization detection (HSS-GC/FID) methods. The presence of unchanged initiator molecule and a dominant amount of four new molecules that were different from homopolymers and the reactant (monomer and cross-linker) were determined.
T2  - Polymers
T1  - Intelligent Poly(N-Isopropylmethacrylamide) Hydrogels: Synthesis, Structure Characterization, Stimuli-Responsive Swelling Properties, and Their Radiation Decomposition
VL  - 12
IS  - 5
SP  - 1112
DO  - 10.3390/polym12051112
ER  - 

@article{
author = "Ilić-Stojanović, Snežana and Urošević, Maja and Nikolić, Ljubiša and Petrović, Đorđe and Stanojević, Jelena and Najman, Stevo and Nikolić, Vesna",
year = "2020",
abstract = "Poly(N-isopropylmethacrylamide) (p(NiPMAm)) is one of the lesser known homopolymers that has significant potential for designing new “intelligent” materials. The aims of this work were the synthesis a series of cross-linked p(NiPMAm) hydrogels by the free radical polymerization method and the application of gamma-ray radiation for additional cross-linking. The synthesized p(NiPMAm) hydrogels were structurally characterized by Fourier transform infrared spectroscopy (FTIR) and scanning electron microscopy (SEM). The amount of unreacted monomers was analyzed using high pressure liquid chromatography (HPLC) to evaluate conversion of monomers into polymers. The swelling behavior was monitored in dependence of pH and temperature changes. The previous aim of gamma-ray radiation was the further the cross-linkage of the obtained hydrogel sample in the gelatinous, paste-like state, but the gamma-ray radiation caused decomposition. After absorbing irradiation doses, they transformed into the liquid phase. The results obtained by the gel permeation chromatography (GPC) method indicated that only oligomers and monomers were present in the irradiated liquid material, without molecules with a higher average molar mass, i.e., that the decomposition of the hydrogels occurred. Additionally, the irradiated liquid material was analyzed using the static headspace gas chromatography mass spectrometry (HSS-GC/MS) and gas chromatography/flame ionization detection (HSS-GC/FID) methods. The presence of unchanged initiator molecule and a dominant amount of four new molecules that were different from homopolymers and the reactant (monomer and cross-linker) were determined.",
journal = "Polymers",
title = "Intelligent Poly(N-Isopropylmethacrylamide) Hydrogels: Synthesis, Structure Characterization, Stimuli-Responsive Swelling Properties, and Their Radiation Decomposition",
volume = "12",
number = "5",
pages = "1112",
doi = "10.3390/polym12051112"
}

Ilić-Stojanović, S., Urošević, M., Nikolić, L., Petrović, Đ., Stanojević, J., Najman, S.,& Nikolić, V.. (2020). Intelligent Poly(N-Isopropylmethacrylamide) Hydrogels: Synthesis, Structure Characterization, Stimuli-Responsive Swelling Properties, and Their Radiation Decomposition. in Polymers, 12(5), 1112.
https://doi.org/10.3390/polym12051112

Ilić-Stojanović S, Urošević M, Nikolić L, Petrović Đ, Stanojević J, Najman S, Nikolić V. Intelligent Poly(N-Isopropylmethacrylamide) Hydrogels: Synthesis, Structure Characterization, Stimuli-Responsive Swelling Properties, and Their Radiation Decomposition. in Polymers. 2020;12(5):1112.
doi:10.3390/polym12051112 .

Ilić-Stojanović, Snežana, Urošević, Maja, Nikolić, Ljubiša, Petrović, Đorđe, Stanojević, Jelena, Najman, Stevo, Nikolić, Vesna, "Intelligent Poly(N-Isopropylmethacrylamide) Hydrogels: Synthesis, Structure Characterization, Stimuli-Responsive Swelling Properties, and Their Radiation Decomposition" in Polymers, 12, no. 5 (2020):1112,
https://doi.org/10.3390/polym12051112 . .

TY  - JOUR
AU  - Đorđević, Ljubiša
AU  - Najman, Stevo
AU  - Vasiljević, Perica
AU  - Miljković, Miroslav
AU  - Ignjatović, Nenad L.
AU  - Uskoković, Dragan
AU  - Plavšić, Milenko
PY  - 2016
UR  - http://dais.sanu.ac.rs/123456789/15457
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/7561
AB  - Implantation of a biomaterial is one of the important trends in solving the problem of bone tissue loss. Calcium hydroxiapatite (HAp), as the most representative bone component is a serious candidate for such implantations. The synthetic polymer poly-L-lactide (PLLA) in HAp/PLLA is often used as a polymeric material, with a role in the substitution of bone tissue collagen fibers. Fibers of PLLA may strengthen HAp and its good bioresorption provides space for tissue remodeling. Differences in porosity, microstructure, compressive consistency as well as bioresorbility of HAp/PLLA may be achieved by using PLLA with different molecular weights. In this study HAp/PLLA composites with PLLA of different molecular weights (50,000; 160,000 and 430,000) were implanted in mouse peritoneum in order to examine the influence of the molecular weight of PLLA on morphology changes. Microstructural changes of biomaterial (HAp/PLLA) surface were analyzed one week, three weeks and four months after their implantation using Scanning Electron Microscopy. The results showed a significant difference in tissue reactions on the applied biocomposites, depending on their molecular weight. The most intense proliferation of cells was induced by HAp/PLLA 50,000 compared to HAp/PLLA 430,000 and HAp/PLLA 160,000. In the vicinity of HAp/PLLA 430,000 abundant erythrocytes were observed. The differences in biological reactions on the examined biocomposites are significant for their practical applications. HAp/PLLA composite biomaterials of different types and resorption rates require specific designing and programming to become suitable for particular purposes in an organism.
T2  - Acta Veterinaria
T1  - Scanning electron microscopy analysis of changes of hydroxiapatite/poly-l-lactide with different molecular weight of PLLA after intraperitoneal implantation
VL  - 66
IS  - 2
SP  - 234
EP  - 244
DO  - 10.1515/acve-2016-0020
ER  - 

@article{
author = "Đorđević, Ljubiša and Najman, Stevo and Vasiljević, Perica and Miljković, Miroslav and Ignjatović, Nenad L. and Uskoković, Dragan and Plavšić, Milenko",
year = "2016",
abstract = "Implantation of a biomaterial is one of the important trends in solving the problem of bone tissue loss. Calcium hydroxiapatite (HAp), as the most representative bone component is a serious candidate for such implantations. The synthetic polymer poly-L-lactide (PLLA) in HAp/PLLA is often used as a polymeric material, with a role in the substitution of bone tissue collagen fibers. Fibers of PLLA may strengthen HAp and its good bioresorption provides space for tissue remodeling. Differences in porosity, microstructure, compressive consistency as well as bioresorbility of HAp/PLLA may be achieved by using PLLA with different molecular weights. In this study HAp/PLLA composites with PLLA of different molecular weights (50,000; 160,000 and 430,000) were implanted in mouse peritoneum in order to examine the influence of the molecular weight of PLLA on morphology changes. Microstructural changes of biomaterial (HAp/PLLA) surface were analyzed one week, three weeks and four months after their implantation using Scanning Electron Microscopy. The results showed a significant difference in tissue reactions on the applied biocomposites, depending on their molecular weight. The most intense proliferation of cells was induced by HAp/PLLA 50,000 compared to HAp/PLLA 430,000 and HAp/PLLA 160,000. In the vicinity of HAp/PLLA 430,000 abundant erythrocytes were observed. The differences in biological reactions on the examined biocomposites are significant for their practical applications. HAp/PLLA composite biomaterials of different types and resorption rates require specific designing and programming to become suitable for particular purposes in an organism.",
journal = "Acta Veterinaria",
title = "Scanning electron microscopy analysis of changes of hydroxiapatite/poly-l-lactide with different molecular weight of PLLA after intraperitoneal implantation",
volume = "66",
number = "2",
pages = "234-244",
doi = "10.1515/acve-2016-0020"
}

Đorđević, L., Najman, S., Vasiljević, P., Miljković, M., Ignjatović, N. L., Uskoković, D.,& Plavšić, M.. (2016). Scanning electron microscopy analysis of changes of hydroxiapatite/poly-l-lactide with different molecular weight of PLLA after intraperitoneal implantation. in Acta Veterinaria, 66(2), 234-244.
https://doi.org/10.1515/acve-2016-0020

Đorđević L, Najman S, Vasiljević P, Miljković M, Ignjatović NL, Uskoković D, Plavšić M. Scanning electron microscopy analysis of changes of hydroxiapatite/poly-l-lactide with different molecular weight of PLLA after intraperitoneal implantation. in Acta Veterinaria. 2016;66(2):234-244.
doi:10.1515/acve-2016-0020 .

Đorđević, Ljubiša, Najman, Stevo, Vasiljević, Perica, Miljković, Miroslav, Ignjatović, Nenad L., Uskoković, Dragan, Plavšić, Milenko, "Scanning electron microscopy analysis of changes of hydroxiapatite/poly-l-lactide with different molecular weight of PLLA after intraperitoneal implantation" in Acta Veterinaria, 66, no. 2 (2016):234-244,
https://doi.org/10.1515/acve-2016-0020 . .

TY  - CONF
AU  - Ajduković, Zorica
AU  - Ignjatović, Nenad L.
AU  - Petrović, Nenad
AU  - Rajković, Jelena
AU  - Kenić Marinković, Dragana
AU  - Najman, Stevo
AU  - Mihailović, Dragan
AU  - Uskoković, Dragan
PY  - 2014
UR  - http://dais.sanu.ac.rs/123456789/558
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/7477
AB  - Recent studies have shown that the behavior of nanoparticles in in vivo conditions is not solely dependant on their physical properties, such are size and shape. The surface of nanoparticles in biological fluids interacts with biomolecules such are proteins, adsorbs these molecules, and leads to formation of nanoparticle-biomoelcular complex known as “protein corona”. This protein corona changes the properties of nanoparticles and their behavior in vivo. In this work three types of nanomaterial based on Hap and polymers were incubated in rats plasma, and the identification and quantification of proteins in protein corona that had formed around these nanoparticles, was done by means of electrophoresis and mass spectrophotometery.
PB  - Belgrade : Materials Research Society of Serbia
C3  - The Sixteenth Annual Conference YUCOMAT 2014: Programme and the Book of Abstracts
T1  - Interaction of nanoparticles and biological fluids
SP  - 113
EP  - 113
UR  - https://hdl.handle.net/21.15107/rcub_vinar_7477
ER  - 

@conference{
author = "Ajduković, Zorica and Ignjatović, Nenad L. and Petrović, Nenad and Rajković, Jelena and Kenić Marinković, Dragana and Najman, Stevo and Mihailović, Dragan and Uskoković, Dragan",
year = "2014",
abstract = "Recent studies have shown that the behavior of nanoparticles in in vivo conditions is not solely dependant on their physical properties, such are size and shape. The surface of nanoparticles in biological fluids interacts with biomolecules such are proteins, adsorbs these molecules, and leads to formation of nanoparticle-biomoelcular complex known as “protein corona”. This protein corona changes the properties of nanoparticles and their behavior in vivo. In this work three types of nanomaterial based on Hap and polymers were incubated in rats plasma, and the identification and quantification of proteins in protein corona that had formed around these nanoparticles, was done by means of electrophoresis and mass spectrophotometery.",
publisher = "Belgrade : Materials Research Society of Serbia",
journal = "The Sixteenth Annual Conference YUCOMAT 2014: Programme and the Book of Abstracts",
title = "Interaction of nanoparticles and biological fluids",
pages = "113-113",
url = "https://hdl.handle.net/21.15107/rcub_vinar_7477"
}

Ajduković, Z., Ignjatović, N. L., Petrović, N., Rajković, J., Kenić Marinković, D., Najman, S., Mihailović, D.,& Uskoković, D.. (2014). Interaction of nanoparticles and biological fluids. in The Sixteenth Annual Conference YUCOMAT 2014: Programme and the Book of Abstracts
Belgrade : Materials Research Society of Serbia., 113-113.
https://hdl.handle.net/21.15107/rcub_vinar_7477

Ajduković Z, Ignjatović NL, Petrović N, Rajković J, Kenić Marinković D, Najman S, Mihailović D, Uskoković D. Interaction of nanoparticles and biological fluids. in The Sixteenth Annual Conference YUCOMAT 2014: Programme and the Book of Abstracts. 2014;:113-113.
https://hdl.handle.net/21.15107/rcub_vinar_7477 .

Ajduković, Zorica, Ignjatović, Nenad L., Petrović, Nenad, Rajković, Jelena, Kenić Marinković, Dragana, Najman, Stevo, Mihailović, Dragan, Uskoković, Dragan, "Interaction of nanoparticles and biological fluids" in The Sixteenth Annual Conference YUCOMAT 2014: Programme and the Book of Abstracts (2014):113-113,
https://hdl.handle.net/21.15107/rcub_vinar_7477 .

TY  - JOUR
AU  - Mitić, Žarko
AU  - Najman, Stevo
AU  - Cakić, Milorad
AU  - Ajduković, Zorica
AU  - Ignjatović, Nenad L.
AU  - Nikolić, Ružica
AU  - Nikolić, Goran
AU  - Stojanović, Sanja
AU  - Vukelić, Marija
AU  - Trajanović, Miroslav
PY  - 2014
UR  - http://dais.sanu.ac.rs/123456789/554
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/7476
AB  - The influence of glucocorticoids on the composition and mineral/organic content of the mandible in tested animals after recovery and healing phase was investigated in this work. The results of FTIR analysis demonstrated that bone tissue composition was changed after glucocorticoid treatment. The increase of calcium, magnesium, phosphorus content and mineral part of bones was statistically significant in recovery phase and in treatment phase that included calcitonin and thymus extract. Some changes also happened in the organic part of the matrix, as indicated by intensity changes for already present IR bands and the appearance of new IR bands in the region 3500–1300 cm−1.
PB  - Elsevier
T2  - Journal of Molecular Structure
T1  - Spectroscopic characterization of bone tissue of experimental animals after glucocorticoid treatment and recovery period
SP  - 315
EP  - 320
DO  - 10.1016/j.molstruc.2014.06.006
ER  - 

@article{
author = "Mitić, Žarko and Najman, Stevo and Cakić, Milorad and Ajduković, Zorica and Ignjatović, Nenad L. and Nikolić, Ružica and Nikolić, Goran and Stojanović, Sanja and Vukelić, Marija and Trajanović, Miroslav",
year = "2014",
abstract = "The influence of glucocorticoids on the composition and mineral/organic content of the mandible in tested animals after recovery and healing phase was investigated in this work. The results of FTIR analysis demonstrated that bone tissue composition was changed after glucocorticoid treatment. The increase of calcium, magnesium, phosphorus content and mineral part of bones was statistically significant in recovery phase and in treatment phase that included calcitonin and thymus extract. Some changes also happened in the organic part of the matrix, as indicated by intensity changes for already present IR bands and the appearance of new IR bands in the region 3500–1300 cm−1.",
publisher = "Elsevier",
journal = "Journal of Molecular Structure",
title = "Spectroscopic characterization of bone tissue of experimental animals after glucocorticoid treatment and recovery period",
pages = "315-320",
doi = "10.1016/j.molstruc.2014.06.006"
}

Mitić, Ž., Najman, S., Cakić, M., Ajduković, Z., Ignjatović, N. L., Nikolić, R., Nikolić, G., Stojanović, S., Vukelić, M.,& Trajanović, M.. (2014). Spectroscopic characterization of bone tissue of experimental animals after glucocorticoid treatment and recovery period. in Journal of Molecular Structure
Elsevier., 315-320.
https://doi.org/10.1016/j.molstruc.2014.06.006

Mitić Ž, Najman S, Cakić M, Ajduković Z, Ignjatović NL, Nikolić R, Nikolić G, Stojanović S, Vukelić M, Trajanović M. Spectroscopic characterization of bone tissue of experimental animals after glucocorticoid treatment and recovery period. in Journal of Molecular Structure. 2014;:315-320.
doi:10.1016/j.molstruc.2014.06.006 .

Mitić, Žarko, Najman, Stevo, Cakić, Milorad, Ajduković, Zorica, Ignjatović, Nenad L., Nikolić, Ružica, Nikolić, Goran, Stojanović, Sanja, Vukelić, Marija, Trajanović, Miroslav, "Spectroscopic characterization of bone tissue of experimental animals after glucocorticoid treatment and recovery period" in Journal of Molecular Structure (2014):315-320,
https://doi.org/10.1016/j.molstruc.2014.06.006 . .

TY  - JOUR
AU  - Ignjatović, Nenad L.
AU  - Ajduković, Zorica
AU  - Savić, Vojin
AU  - Najman, Stevo
AU  - Mihailović, Dragan
AU  - Vasiljević, Perica
AU  - Stojanović, Zoran S.
AU  - Uskoković, Vuk
AU  - Uskoković, Dragan
PY  - 2013
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/7410
AB  - Indications exist that paramagnetic calcium phosphates may be able to promote regeneration of bone faster than their regular, diamagnetic counterparts. In this study, analyzed was the influence of paramagnetic cobalt-substituted hydroxyapatite nanoparticles on osteoporotic alveolar bone regeneration in rats. Simultaneously, biocompatibility of the material was tested in vitro, on osteoblastic MC3T3-E1 and epithelial Caco-2 cells in culture. The material was shown to be biocompatible and nontoxic when added to epithelial monolayers in vitro, while it caused a substantial decrease in the cell viability as well as deformation of the cytoskeleton and cell morphology when incubated with the osteoblastic cells. In the course of 6 months after the implantation of the material containing different amounts of cobalt, ranging from 5 to 12 wt%, in the osteoporotic alveolar bone of the lower jaw, the following parameters were investigated: histopathological parameters, alkaline phosphatase and alveolar bone density. The best result in terms of osteoporotic bone tissue regeneration was observed for hydroxyapatite nanoparticles with the largest content of cobalt ions. The histological analysis showed a high level of reparatory ability of the nanoparticulate material implanted in the bone defect, paralleled by a corresponding increase in the alveolar bone density. The combined effect of growth factors from autologous plasma admixed to cobalt-substituted hydroxyapatite was furthermore shown to have a crucial effect on the augmented osteoporotic bone regeneration upon the implantation of the biomaterial investigated in this study.
T2  - Journal of Materials Science: Materials in Medicine
T1  - Nanoparticles of cobalt-substituted hydroxyapatite in regeneration of mandibular osteoporotic bones
SP  - 343
EP  - 354
DO  - 10.1007/s10856-012-4793-1
ER  - 

@article{
author = "Ignjatović, Nenad L. and Ajduković, Zorica and Savić, Vojin and Najman, Stevo and Mihailović, Dragan and Vasiljević, Perica and Stojanović, Zoran S. and Uskoković, Vuk and Uskoković, Dragan",
year = "2013",
abstract = "Indications exist that paramagnetic calcium phosphates may be able to promote regeneration of bone faster than their regular, diamagnetic counterparts. In this study, analyzed was the influence of paramagnetic cobalt-substituted hydroxyapatite nanoparticles on osteoporotic alveolar bone regeneration in rats. Simultaneously, biocompatibility of the material was tested in vitro, on osteoblastic MC3T3-E1 and epithelial Caco-2 cells in culture. The material was shown to be biocompatible and nontoxic when added to epithelial monolayers in vitro, while it caused a substantial decrease in the cell viability as well as deformation of the cytoskeleton and cell morphology when incubated with the osteoblastic cells. In the course of 6 months after the implantation of the material containing different amounts of cobalt, ranging from 5 to 12 wt%, in the osteoporotic alveolar bone of the lower jaw, the following parameters were investigated: histopathological parameters, alkaline phosphatase and alveolar bone density. The best result in terms of osteoporotic bone tissue regeneration was observed for hydroxyapatite nanoparticles with the largest content of cobalt ions. The histological analysis showed a high level of reparatory ability of the nanoparticulate material implanted in the bone defect, paralleled by a corresponding increase in the alveolar bone density. The combined effect of growth factors from autologous plasma admixed to cobalt-substituted hydroxyapatite was furthermore shown to have a crucial effect on the augmented osteoporotic bone regeneration upon the implantation of the biomaterial investigated in this study.",
journal = "Journal of Materials Science: Materials in Medicine",
title = "Nanoparticles of cobalt-substituted hydroxyapatite in regeneration of mandibular osteoporotic bones",
pages = "343-354",
doi = "10.1007/s10856-012-4793-1"
}

Ignjatović, N. L., Ajduković, Z., Savić, V., Najman, S., Mihailović, D., Vasiljević, P., Stojanović, Z. S., Uskoković, V.,& Uskoković, D.. (2013). Nanoparticles of cobalt-substituted hydroxyapatite in regeneration of mandibular osteoporotic bones. in Journal of Materials Science: Materials in Medicine, 343-354.
https://doi.org/10.1007/s10856-012-4793-1

Ignjatović NL, Ajduković Z, Savić V, Najman S, Mihailović D, Vasiljević P, Stojanović ZS, Uskoković V, Uskoković D. Nanoparticles of cobalt-substituted hydroxyapatite in regeneration of mandibular osteoporotic bones. in Journal of Materials Science: Materials in Medicine. 2013;:343-354.
doi:10.1007/s10856-012-4793-1 .

Ignjatović, Nenad L., Ajduković, Zorica, Savić, Vojin, Najman, Stevo, Mihailović, Dragan, Vasiljević, Perica, Stojanović, Zoran S., Uskoković, Vuk, Uskoković, Dragan, "Nanoparticles of cobalt-substituted hydroxyapatite in regeneration of mandibular osteoporotic bones" in Journal of Materials Science: Materials in Medicine (2013):343-354,
https://doi.org/10.1007/s10856-012-4793-1 . .

TY  - JOUR
AU  - Ignjatović, Nenad L.
AU  - Ajduković, Zorica
AU  - Savić, Vojin
AU  - Najman, Stevo
AU  - Mihailović, Dragan
AU  - Vasiljević, Perica
AU  - Stojanović, Zoran S.
AU  - Uskoković, Vuk
AU  - Uskoković, Dragan
PY  - 2013
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/7481
AB  - Indications exist that paramagnetic calcium phosphates may be able to promote regeneration of bone faster than their regular, diamagnetic counterparts. In this study, analyzed was the influence of paramagnetic cobalt-substituted hydroxyapatite nanoparticles on osteoporotic alveolar bone regeneration in rats. Simultaneously, biocompatibility of the material was tested in vitro, on osteoblastic MC3T3-E1 and epithelial Caco-2 cells in culture. The material was shown to be biocompatible and nontoxic when added to epithelial monolayers in vitro, while it caused a substantial decrease in the cell viability as well as deformation of the cytoskeleton and cell morphology when incubated with the osteoblastic cells. In the course of 6 months after the implantation of the material containing different amounts of cobalt, ranging from 5 to 12 wt%, in the osteoporotic alveolar bone of the lower jaw, the following parameters were investigated: histopathological parameters, alkaline phosphatase and alveolar bone density. The best result in terms of osteoporotic bone tissue regeneration was observed for hydroxyapatite nanoparticles with the largest content of cobalt ions. The histological analysis showed a high level of reparatory ability of the nanoparticulate material implanted in the bone defect, paralleled by a corresponding increase in the alveolar bone density. The combined effect of growth factors from autologous plasma admixed to cobalt-substituted hydroxyapatite was furthermore shown to have a crucial effect on the augmented osteoporotic bone regeneration upon the implantation of the biomaterial investigated in this study.
T2  - Journal of Materials Science: Materials in Medicine
T1  - Nanoparticles of cobalt-substituted hydroxyapatite in regeneration of mandibular osteoporotic bones
SP  - 343
EP  - 354
DO  - 10.1007/s10856-012-4793-1
ER  - 

@article{
author = "Ignjatović, Nenad L. and Ajduković, Zorica and Savić, Vojin and Najman, Stevo and Mihailović, Dragan and Vasiljević, Perica and Stojanović, Zoran S. and Uskoković, Vuk and Uskoković, Dragan",
year = "2013",
abstract = "Indications exist that paramagnetic calcium phosphates may be able to promote regeneration of bone faster than their regular, diamagnetic counterparts. In this study, analyzed was the influence of paramagnetic cobalt-substituted hydroxyapatite nanoparticles on osteoporotic alveolar bone regeneration in rats. Simultaneously, biocompatibility of the material was tested in vitro, on osteoblastic MC3T3-E1 and epithelial Caco-2 cells in culture. The material was shown to be biocompatible and nontoxic when added to epithelial monolayers in vitro, while it caused a substantial decrease in the cell viability as well as deformation of the cytoskeleton and cell morphology when incubated with the osteoblastic cells. In the course of 6 months after the implantation of the material containing different amounts of cobalt, ranging from 5 to 12 wt%, in the osteoporotic alveolar bone of the lower jaw, the following parameters were investigated: histopathological parameters, alkaline phosphatase and alveolar bone density. The best result in terms of osteoporotic bone tissue regeneration was observed for hydroxyapatite nanoparticles with the largest content of cobalt ions. The histological analysis showed a high level of reparatory ability of the nanoparticulate material implanted in the bone defect, paralleled by a corresponding increase in the alveolar bone density. The combined effect of growth factors from autologous plasma admixed to cobalt-substituted hydroxyapatite was furthermore shown to have a crucial effect on the augmented osteoporotic bone regeneration upon the implantation of the biomaterial investigated in this study.",
journal = "Journal of Materials Science: Materials in Medicine",
title = "Nanoparticles of cobalt-substituted hydroxyapatite in regeneration of mandibular osteoporotic bones",
pages = "343-354",
doi = "10.1007/s10856-012-4793-1"
}

Ignjatović, N. L., Ajduković, Z., Savić, V., Najman, S., Mihailović, D., Vasiljević, P., Stojanović, Z. S., Uskoković, V.,& Uskoković, D.. (2013). Nanoparticles of cobalt-substituted hydroxyapatite in regeneration of mandibular osteoporotic bones. in Journal of Materials Science: Materials in Medicine, 343-354.
https://doi.org/10.1007/s10856-012-4793-1

Ignjatović NL, Ajduković Z, Savić V, Najman S, Mihailović D, Vasiljević P, Stojanović ZS, Uskoković V, Uskoković D. Nanoparticles of cobalt-substituted hydroxyapatite in regeneration of mandibular osteoporotic bones. in Journal of Materials Science: Materials in Medicine. 2013;:343-354.
doi:10.1007/s10856-012-4793-1 .

Ignjatović, Nenad L., Ajduković, Zorica, Savić, Vojin, Najman, Stevo, Mihailović, Dragan, Vasiljević, Perica, Stojanović, Zoran S., Uskoković, Vuk, Uskoković, Dragan, "Nanoparticles of cobalt-substituted hydroxyapatite in regeneration of mandibular osteoporotic bones" in Journal of Materials Science: Materials in Medicine (2013):343-354,
https://doi.org/10.1007/s10856-012-4793-1 . .

TY  - CONF
AU  - Stojanović, S.
AU  - Mitić, Ž.
AU  - Najman, Stevo
AU  - Ignjatović, Nenad L.
AU  - Uskoković, Dragan
PY  - 2013
UR  - http://dais.sanu.ac.rs/123456789/406
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/7422
AB  - In this study we observed the changes in surface of nanoparticles of two different nanomaterials, cobalt-substituted hydroxyapatite (CoHAp) and calcium phosphate/poly-(DLlactide-co-glycolide) (CP/PLGA) that occurred under simulated physiological conditions in vitro. Both nanomaterials were incubated in an appropriate volume of Dulbecco's Modified Eagle Medium (DMEM) for 3 days at 37 0C and then the medium was removed and materials were dried. Surface changes of nanoparticles were studied by scanning electron microscopy (SEM). Results of SEM analysis show that changes in the size and shape of the nanoparticles took place. These changes can be explained by interactions of nanomaterials with DMEM. In the case of CP/PLGA it was probably the result of polymer degradation and changes in CoHAp nanoparticles were probably the result of ion exchange.
PB  - Belgrade : Materials Research Society of Serbia
C3  - The Fifteenth Annual Conference YUCOMAT 2013: Programme and the Book of Abstracts
T1  - Scanning electron microscopy study of changes in nanoparticles surface under in vitro simulated physiological conditions
SP  - 149
EP  - 149
UR  - https://hdl.handle.net/21.15107/rcub_vinar_7422
ER  - 

@conference{
author = "Stojanović, S. and Mitić, Ž. and Najman, Stevo and Ignjatović, Nenad L. and Uskoković, Dragan",
year = "2013",
abstract = "In this study we observed the changes in surface of nanoparticles of two different nanomaterials, cobalt-substituted hydroxyapatite (CoHAp) and calcium phosphate/poly-(DLlactide-co-glycolide) (CP/PLGA) that occurred under simulated physiological conditions in vitro. Both nanomaterials were incubated in an appropriate volume of Dulbecco's Modified Eagle Medium (DMEM) for 3 days at 37 0C and then the medium was removed and materials were dried. Surface changes of nanoparticles were studied by scanning electron microscopy (SEM). Results of SEM analysis show that changes in the size and shape of the nanoparticles took place. These changes can be explained by interactions of nanomaterials with DMEM. In the case of CP/PLGA it was probably the result of polymer degradation and changes in CoHAp nanoparticles were probably the result of ion exchange.",
publisher = "Belgrade : Materials Research Society of Serbia",
journal = "The Fifteenth Annual Conference YUCOMAT 2013: Programme and the Book of Abstracts",
title = "Scanning electron microscopy study of changes in nanoparticles surface under in vitro simulated physiological conditions",
pages = "149-149",
url = "https://hdl.handle.net/21.15107/rcub_vinar_7422"
}

Stojanović, S., Mitić, Ž., Najman, S., Ignjatović, N. L.,& Uskoković, D.. (2013). Scanning electron microscopy study of changes in nanoparticles surface under in vitro simulated physiological conditions. in The Fifteenth Annual Conference YUCOMAT 2013: Programme and the Book of Abstracts
Belgrade : Materials Research Society of Serbia., 149-149.
https://hdl.handle.net/21.15107/rcub_vinar_7422

Stojanović S, Mitić Ž, Najman S, Ignjatović NL, Uskoković D. Scanning electron microscopy study of changes in nanoparticles surface under in vitro simulated physiological conditions. in The Fifteenth Annual Conference YUCOMAT 2013: Programme and the Book of Abstracts. 2013;:149-149.
https://hdl.handle.net/21.15107/rcub_vinar_7422 .

Stojanović, S., Mitić, Ž., Najman, Stevo, Ignjatović, Nenad L., Uskoković, Dragan, "Scanning electron microscopy study of changes in nanoparticles surface under in vitro simulated physiological conditions" in The Fifteenth Annual Conference YUCOMAT 2013: Programme and the Book of Abstracts (2013):149-149,
https://hdl.handle.net/21.15107/rcub_vinar_7422 .

TY  - CONF
AU  - Najman, Stevo
AU  - Petrović, Dragan
AU  - Vučković, Ivan
AU  - Živković, J.
AU  - Stojanović, S.
AU  - Ignjatović, Nenad L.
AU  - Uskoković, Dragan
PY  - 2013
UR  - http://dais.sanu.ac.rs/123456789/400
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/7419
AB  - The aim of this study was to investigate the osteogenic potential of freshly isolated adipose tissue-derived mesenchymal stromal/stem cells (ASCs) in bone regeneration of rabbit calvaria defects. ASCs were applied together with calcium phosphate-poly-DL-lactide-co-glycolide (CPPLGA) nanoparticles that are mixed in an appropriately prepared blood clot (BC). Parallelly were analysed defects filled with fragmented adipose tissue (FAT) instead of ASCs, with CP-PLGA in BC, and only with nanoparticles. Bone density in defects was measured after I, III and VI weeks, and histological examination was done after IV and VIII weeks after filling defects. Approach to assisted osteoregeneration which is based on the use of fresh non-induced ASCs has proven to be promising due to the favorable effect on bone regeneration and simplicity of their application.
PB  - Belgrade : Materials Research Society of Serbia
C3  - The Fifteenth Annual Conference YUCOMAT 2013: Programme and the Book of Abstracts
T1  - Osteogenic potential of freshly isolated cells of adiposederived mesenchymal fraction applied with nanoparticles
SP  - 45
EP  - 45
UR  - https://hdl.handle.net/21.15107/rcub_vinar_7419
ER  - 

@conference{
author = "Najman, Stevo and Petrović, Dragan and Vučković, Ivan and Živković, J. and Stojanović, S. and Ignjatović, Nenad L. and Uskoković, Dragan",
year = "2013",
abstract = "The aim of this study was to investigate the osteogenic potential of freshly isolated adipose tissue-derived mesenchymal stromal/stem cells (ASCs) in bone regeneration of rabbit calvaria defects. ASCs were applied together with calcium phosphate-poly-DL-lactide-co-glycolide (CPPLGA) nanoparticles that are mixed in an appropriately prepared blood clot (BC). Parallelly were analysed defects filled with fragmented adipose tissue (FAT) instead of ASCs, with CP-PLGA in BC, and only with nanoparticles. Bone density in defects was measured after I, III and VI weeks, and histological examination was done after IV and VIII weeks after filling defects. Approach to assisted osteoregeneration which is based on the use of fresh non-induced ASCs has proven to be promising due to the favorable effect on bone regeneration and simplicity of their application.",
publisher = "Belgrade : Materials Research Society of Serbia",
journal = "The Fifteenth Annual Conference YUCOMAT 2013: Programme and the Book of Abstracts",
title = "Osteogenic potential of freshly isolated cells of adiposederived mesenchymal fraction applied with nanoparticles",
pages = "45-45",
url = "https://hdl.handle.net/21.15107/rcub_vinar_7419"
}

Najman, S., Petrović, D., Vučković, I., Živković, J., Stojanović, S., Ignjatović, N. L.,& Uskoković, D.. (2013). Osteogenic potential of freshly isolated cells of adiposederived mesenchymal fraction applied with nanoparticles. in The Fifteenth Annual Conference YUCOMAT 2013: Programme and the Book of Abstracts
Belgrade : Materials Research Society of Serbia., 45-45.
https://hdl.handle.net/21.15107/rcub_vinar_7419

Najman S, Petrović D, Vučković I, Živković J, Stojanović S, Ignjatović NL, Uskoković D. Osteogenic potential of freshly isolated cells of adiposederived mesenchymal fraction applied with nanoparticles. in The Fifteenth Annual Conference YUCOMAT 2013: Programme and the Book of Abstracts. 2013;:45-45.
https://hdl.handle.net/21.15107/rcub_vinar_7419 .

Najman, Stevo, Petrović, Dragan, Vučković, Ivan, Živković, J., Stojanović, S., Ignjatović, Nenad L., Uskoković, Dragan, "Osteogenic potential of freshly isolated cells of adiposederived mesenchymal fraction applied with nanoparticles" in The Fifteenth Annual Conference YUCOMAT 2013: Programme and the Book of Abstracts (2013):45-45,
https://hdl.handle.net/21.15107/rcub_vinar_7419 .

TY  - CONF
AU  - Ajduković, Zorica
AU  - Ignjatović, Nenad L.
AU  - Petrović, N.
AU  - Rajković, J.
AU  - Kenić Marinković, D.
AU  - Najman, Stevo
AU  - Uskoković, Dragan
PY  - 2013
UR  - http://dais.sanu.ac.rs/123456789/388
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/7413
AB  - The lack of bone in the jaw tegmenta inflicts major problem and leads to an inability to adequately treat stomatoprosthetic patients. If the bone tissue damage is minor, the balanced activities of osteoblasts and bone osteoclasts can repair it independently. If the damage is bigger it is necessary to support the biological potential to repair the bone, and for that reason nanoparticlebiomaterial Ca / Co-HAp was used in this study. The research was done on rats with uniform anatomical and physiological characteristics. Assessment of repair and consolidation of the jaw bone tegmenta was performed by istomorphometric and SEM analysis. The best results were obtained in the experimental group of animals where the Ca / Co-Hap was mixed with autologousplasma. Following the implementation of the above mentioned nanocomposites, a significant formation of new bone was evident on the SEM analysis, as well as the rising of histomorphometric parameters of bone formation, which indicates that the Ca / Co-HAp nanocomposite is the material of choice for the rapid regeneration and repair of bone jaw tegmenta.
PB  - Belgrade : Materials Research Society of Serbia
C3  - The Fifteenth Annual Conference YUCOMAT 2013: Programme and the Book of Abstracts
T1  - Nanoparticles Ca/Co-HAp in the treatment of weakened bones jaw tegmenta
SP  - 147
EP  - 147
UR  - https://hdl.handle.net/21.15107/rcub_vinar_7413
ER  - 

@conference{
author = "Ajduković, Zorica and Ignjatović, Nenad L. and Petrović, N. and Rajković, J. and Kenić Marinković, D. and Najman, Stevo and Uskoković, Dragan",
year = "2013",
abstract = "The lack of bone in the jaw tegmenta inflicts major problem and leads to an inability to adequately treat stomatoprosthetic patients. If the bone tissue damage is minor, the balanced activities of osteoblasts and bone osteoclasts can repair it independently. If the damage is bigger it is necessary to support the biological potential to repair the bone, and for that reason nanoparticlebiomaterial Ca / Co-HAp was used in this study. The research was done on rats with uniform anatomical and physiological characteristics. Assessment of repair and consolidation of the jaw bone tegmenta was performed by istomorphometric and SEM analysis. The best results were obtained in the experimental group of animals where the Ca / Co-Hap was mixed with autologousplasma. Following the implementation of the above mentioned nanocomposites, a significant formation of new bone was evident on the SEM analysis, as well as the rising of histomorphometric parameters of bone formation, which indicates that the Ca / Co-HAp nanocomposite is the material of choice for the rapid regeneration and repair of bone jaw tegmenta.",
publisher = "Belgrade : Materials Research Society of Serbia",
journal = "The Fifteenth Annual Conference YUCOMAT 2013: Programme and the Book of Abstracts",
title = "Nanoparticles Ca/Co-HAp in the treatment of weakened bones jaw tegmenta",
pages = "147-147",
url = "https://hdl.handle.net/21.15107/rcub_vinar_7413"
}

Ajduković, Z., Ignjatović, N. L., Petrović, N., Rajković, J., Kenić Marinković, D., Najman, S.,& Uskoković, D.. (2013). Nanoparticles Ca/Co-HAp in the treatment of weakened bones jaw tegmenta. in The Fifteenth Annual Conference YUCOMAT 2013: Programme and the Book of Abstracts
Belgrade : Materials Research Society of Serbia., 147-147.
https://hdl.handle.net/21.15107/rcub_vinar_7413

Ajduković Z, Ignjatović NL, Petrović N, Rajković J, Kenić Marinković D, Najman S, Uskoković D. Nanoparticles Ca/Co-HAp in the treatment of weakened bones jaw tegmenta. in The Fifteenth Annual Conference YUCOMAT 2013: Programme and the Book of Abstracts. 2013;:147-147.
https://hdl.handle.net/21.15107/rcub_vinar_7413 .

Ajduković, Zorica, Ignjatović, Nenad L., Petrović, N., Rajković, J., Kenić Marinković, D., Najman, Stevo, Uskoković, Dragan, "Nanoparticles Ca/Co-HAp in the treatment of weakened bones jaw tegmenta" in The Fifteenth Annual Conference YUCOMAT 2013: Programme and the Book of Abstracts (2013):147-147,
https://hdl.handle.net/21.15107/rcub_vinar_7413 .

TY  - CONF
AU  - Najman, Stevo
AU  - Stojanović, Sanja
AU  - Mitrić, Žarko
AU  - Ajduković, Zorica
AU  - Ignjatović, Nenad L.
AU  - Uskoković, Dragan
PY  - 2012
UR  - http://dais.sanu.ac.rs/123456789/519
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/7466
AB  - We have examined the effect of extracts of the calcium phosphate/poly(DL-lactide-co-glycolide) (CP/PLGA) and cobalt-exchanged hydroxyapatite (CoHAp), on the viability of Saos2 osteoblastlike cells. Extracts were prepared by incubation for 3 days at 37°C in the cultivation medium. Conductivity and pH value of extracts were measured before viability assay. Cell viability was estimated by MTT test performed after 24 h incubation of cells with various concentrations of extracts. Extract of CP/PLGA acted more cytotoxic on osteoblasts than the extract of CoHAp. This difference in the effect of examined extracts can be explained by their different pH value and conductivity.
PB  - Belgrade : Materials Research Society of Serbia; Institute of Technical Sciences of SASA; Vinča Institute of Nuclear Sciences, University of Belgrade
C3  - Joint Event of the 11th Young Researchers’ Conference: Materials Science and Engineering and the 1st European Early Stage Researches’ Conference on Hydrogen Storage: Program and the Book of Abstracts
T1  - Examination of the influence of nanomaterials calcium phosphate/poly(DL-lactide-co-glycolide) and cobalt-exchanged hydroxyapatite on the viability of Saos-2 cells
SP  - 110
EP  - 110
UR  - https://hdl.handle.net/21.15107/rcub_vinar_7466
ER  - 

@conference{
author = "Najman, Stevo and Stojanović, Sanja and Mitrić, Žarko and Ajduković, Zorica and Ignjatović, Nenad L. and Uskoković, Dragan",
year = "2012",
abstract = "We have examined the effect of extracts of the calcium phosphate/poly(DL-lactide-co-glycolide) (CP/PLGA) and cobalt-exchanged hydroxyapatite (CoHAp), on the viability of Saos2 osteoblastlike cells. Extracts were prepared by incubation for 3 days at 37°C in the cultivation medium. Conductivity and pH value of extracts were measured before viability assay. Cell viability was estimated by MTT test performed after 24 h incubation of cells with various concentrations of extracts. Extract of CP/PLGA acted more cytotoxic on osteoblasts than the extract of CoHAp. This difference in the effect of examined extracts can be explained by their different pH value and conductivity.",
publisher = "Belgrade : Materials Research Society of Serbia; Institute of Technical Sciences of SASA; Vinča Institute of Nuclear Sciences, University of Belgrade",
journal = "Joint Event of the 11th Young Researchers’ Conference: Materials Science and Engineering and the 1st European Early Stage Researches’ Conference on Hydrogen Storage: Program and the Book of Abstracts",
title = "Examination of the influence of nanomaterials calcium phosphate/poly(DL-lactide-co-glycolide) and cobalt-exchanged hydroxyapatite on the viability of Saos-2 cells",
pages = "110-110",
url = "https://hdl.handle.net/21.15107/rcub_vinar_7466"
}

Najman, S., Stojanović, S., Mitrić, Ž., Ajduković, Z., Ignjatović, N. L.,& Uskoković, D.. (2012). Examination of the influence of nanomaterials calcium phosphate/poly(DL-lactide-co-glycolide) and cobalt-exchanged hydroxyapatite on the viability of Saos-2 cells. in Joint Event of the 11th Young Researchers’ Conference: Materials Science and Engineering and the 1st European Early Stage Researches’ Conference on Hydrogen Storage: Program and the Book of Abstracts
Belgrade : Materials Research Society of Serbia; Institute of Technical Sciences of SASA; Vinča Institute of Nuclear Sciences, University of Belgrade., 110-110.
https://hdl.handle.net/21.15107/rcub_vinar_7466

Najman S, Stojanović S, Mitrić Ž, Ajduković Z, Ignjatović NL, Uskoković D. Examination of the influence of nanomaterials calcium phosphate/poly(DL-lactide-co-glycolide) and cobalt-exchanged hydroxyapatite on the viability of Saos-2 cells. in Joint Event of the 11th Young Researchers’ Conference: Materials Science and Engineering and the 1st European Early Stage Researches’ Conference on Hydrogen Storage: Program and the Book of Abstracts. 2012;:110-110.
https://hdl.handle.net/21.15107/rcub_vinar_7466 .

Najman, Stevo, Stojanović, Sanja, Mitrić, Žarko, Ajduković, Zorica, Ignjatović, Nenad L., Uskoković, Dragan, "Examination of the influence of nanomaterials calcium phosphate/poly(DL-lactide-co-glycolide) and cobalt-exchanged hydroxyapatite on the viability of Saos-2 cells" in Joint Event of the 11th Young Researchers’ Conference: Materials Science and Engineering and the 1st European Early Stage Researches’ Conference on Hydrogen Storage: Program and the Book of Abstracts (2012):110-110,
https://hdl.handle.net/21.15107/rcub_vinar_7466 .

TY  - CONF
AU  - Ajduković, Zorica
AU  - Ignjatović, Nenad L.
AU  - Petrović, N.
AU  - Najman, Stevo
AU  - Rajković, J.
AU  - Kenić Marinković, D.
AU  - Krstić, V.
AU  - Uskoković, Dragan
PY  - 2012
UR  - http://dais.sanu.ac.rs/123456789/497
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/7453
AB  - Huge range of tested biomaterials in recent decades has emerged as an ideal scaffold for cell growth, but few have demonstrated clinical efficacy. Among them, synthetic hydroxyapatite (HAp, Ca10(PO4)6(OH)2) is the most promising because of its biocompatibility, bioactivity, and osteoconductivity. Biocompatibility represents the primary concern for any material to be used as a substitute for natural tissue. Hydroxyapatite particles interact with numerous cellular systems in vivo, and some of these interactions may lead to cell damage and to stimulate platelet activation, coagulation and thrombus formation. The aim of this work was to examine the hemocompatibility of nanocalcium hydroxyapatite substituted with 5% and 12% cobalt (Ca /CoHAp) and hydroxyapatite/polylactidcoglicolid (HAp / PLGA) in relation to pure HAp by testing their hemolytic activities. The results show the discrepancy in hemolytic activity of implanted matherials. The degree of crystallinity of samples had a more dominant influence on hemolysis than the percentage of substituted cobalt. Hemolysis ratios of the nanocalcium hydroxyapatite substituted with cobalt samples were below 3%, indicating good blood compatibility and that they are promising for medical application.
PB  - Belgrade : Materials Research Society of Serbia; Institute of Technical Sciences of SASA; Vinča Institute of Nuclear Sciences, University of Belgrade
C3  - Joint Event of the 11th Young Researchers’ Conference: Materials Science and Engineering and the 1st European Early Stage Researches’ Conference on Hydrogen Storage: Program and the Book of Abstracts
T1  - Hemolytic activity of bioactive nanocomposites
SP  - 49
EP  - 49
UR  - https://hdl.handle.net/21.15107/rcub_vinar_7453
ER  - 

@conference{
author = "Ajduković, Zorica and Ignjatović, Nenad L. and Petrović, N. and Najman, Stevo and Rajković, J. and Kenić Marinković, D. and Krstić, V. and Uskoković, Dragan",
year = "2012",
abstract = "Huge range of tested biomaterials in recent decades has emerged as an ideal scaffold for cell growth, but few have demonstrated clinical efficacy. Among them, synthetic hydroxyapatite (HAp, Ca10(PO4)6(OH)2) is the most promising because of its biocompatibility, bioactivity, and osteoconductivity. Biocompatibility represents the primary concern for any material to be used as a substitute for natural tissue. Hydroxyapatite particles interact with numerous cellular systems in vivo, and some of these interactions may lead to cell damage and to stimulate platelet activation, coagulation and thrombus formation. The aim of this work was to examine the hemocompatibility of nanocalcium hydroxyapatite substituted with 5% and 12% cobalt (Ca /CoHAp) and hydroxyapatite/polylactidcoglicolid (HAp / PLGA) in relation to pure HAp by testing their hemolytic activities. The results show the discrepancy in hemolytic activity of implanted matherials. The degree of crystallinity of samples had a more dominant influence on hemolysis than the percentage of substituted cobalt. Hemolysis ratios of the nanocalcium hydroxyapatite substituted with cobalt samples were below 3%, indicating good blood compatibility and that they are promising for medical application.",
publisher = "Belgrade : Materials Research Society of Serbia; Institute of Technical Sciences of SASA; Vinča Institute of Nuclear Sciences, University of Belgrade",
journal = "Joint Event of the 11th Young Researchers’ Conference: Materials Science and Engineering and the 1st European Early Stage Researches’ Conference on Hydrogen Storage: Program and the Book of Abstracts",
title = "Hemolytic activity of bioactive nanocomposites",
pages = "49-49",
url = "https://hdl.handle.net/21.15107/rcub_vinar_7453"
}

Ajduković, Z., Ignjatović, N. L., Petrović, N., Najman, S., Rajković, J., Kenić Marinković, D., Krstić, V.,& Uskoković, D.. (2012). Hemolytic activity of bioactive nanocomposites. in Joint Event of the 11th Young Researchers’ Conference: Materials Science and Engineering and the 1st European Early Stage Researches’ Conference on Hydrogen Storage: Program and the Book of Abstracts
Belgrade : Materials Research Society of Serbia; Institute of Technical Sciences of SASA; Vinča Institute of Nuclear Sciences, University of Belgrade., 49-49.
https://hdl.handle.net/21.15107/rcub_vinar_7453

Ajduković Z, Ignjatović NL, Petrović N, Najman S, Rajković J, Kenić Marinković D, Krstić V, Uskoković D. Hemolytic activity of bioactive nanocomposites. in Joint Event of the 11th Young Researchers’ Conference: Materials Science and Engineering and the 1st European Early Stage Researches’ Conference on Hydrogen Storage: Program and the Book of Abstracts. 2012;:49-49.
https://hdl.handle.net/21.15107/rcub_vinar_7453 .

Ajduković, Zorica, Ignjatović, Nenad L., Petrović, N., Najman, Stevo, Rajković, J., Kenić Marinković, D., Krstić, V., Uskoković, Dragan, "Hemolytic activity of bioactive nanocomposites" in Joint Event of the 11th Young Researchers’ Conference: Materials Science and Engineering and the 1st European Early Stage Researches’ Conference on Hydrogen Storage: Program and the Book of Abstracts (2012):49-49,
https://hdl.handle.net/21.15107/rcub_vinar_7453 .

TY  - CONF
AU  - Ajduković, Zorica
AU  - Ignjatović, Nenad L.
AU  - Rajković, Jelena
AU  - Najman, Stevo
AU  - Mihailović, D.
AU  - Petrović, N.
AU  - Kenić Marinković, D.
AU  - Uskoković, Dragan
PY  - 2012
UR  - http://dais.sanu.ac.rs/123456789/498
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/7454
AB  - Bone loss during the systemic osteoporosis has an important role in dentistry and medicine. The aim of the study was the application of bioactive micro and nanocomposite materials, alone, and in combination with autologous plasma in osteoporotic jaw bones of rats with artificially induced osteoporosis. The effect of these composites was measured by histomorphometric and atomic absorption spectrophotometric analysis. According to the best obtained results in regeneration and recovery of the resorbed alveolar bone, it can be concluded that nanocomposite combined with autologous plasma may be the material of choice to replace the osteoporotic damaged jaw bone.
PB  - Belgrade : Materials Research Society of Serbia; Institute of Technical Sciences of SASA; Vinča Institute of Nuclear Sciences, University of Belgrade
C3  - Joint Event of the 11th Young Researchers’ Conference: Materials Science and Engineering and the 1st European Early Stage Researches’ Conference on Hydrogen Storage: Program and the Book of Abstracts
T1  - Bioactive composite materials in regeneration of the resorbed bone of alveolar ridges
SP  - 103
EP  - 103
UR  - https://hdl.handle.net/21.15107/rcub_vinar_7454
ER  - 

@conference{
author = "Ajduković, Zorica and Ignjatović, Nenad L. and Rajković, Jelena and Najman, Stevo and Mihailović, D. and Petrović, N. and Kenić Marinković, D. and Uskoković, Dragan",
year = "2012",
abstract = "Bone loss during the systemic osteoporosis has an important role in dentistry and medicine. The aim of the study was the application of bioactive micro and nanocomposite materials, alone, and in combination with autologous plasma in osteoporotic jaw bones of rats with artificially induced osteoporosis. The effect of these composites was measured by histomorphometric and atomic absorption spectrophotometric analysis. According to the best obtained results in regeneration and recovery of the resorbed alveolar bone, it can be concluded that nanocomposite combined with autologous plasma may be the material of choice to replace the osteoporotic damaged jaw bone.",
publisher = "Belgrade : Materials Research Society of Serbia; Institute of Technical Sciences of SASA; Vinča Institute of Nuclear Sciences, University of Belgrade",
journal = "Joint Event of the 11th Young Researchers’ Conference: Materials Science and Engineering and the 1st European Early Stage Researches’ Conference on Hydrogen Storage: Program and the Book of Abstracts",
title = "Bioactive composite materials in regeneration of the resorbed bone of alveolar ridges",
pages = "103-103",
url = "https://hdl.handle.net/21.15107/rcub_vinar_7454"
}

Ajduković, Z., Ignjatović, N. L., Rajković, J., Najman, S., Mihailović, D., Petrović, N., Kenić Marinković, D.,& Uskoković, D.. (2012). Bioactive composite materials in regeneration of the resorbed bone of alveolar ridges. in Joint Event of the 11th Young Researchers’ Conference: Materials Science and Engineering and the 1st European Early Stage Researches’ Conference on Hydrogen Storage: Program and the Book of Abstracts
Belgrade : Materials Research Society of Serbia; Institute of Technical Sciences of SASA; Vinča Institute of Nuclear Sciences, University of Belgrade., 103-103.
https://hdl.handle.net/21.15107/rcub_vinar_7454

Ajduković Z, Ignjatović NL, Rajković J, Najman S, Mihailović D, Petrović N, Kenić Marinković D, Uskoković D. Bioactive composite materials in regeneration of the resorbed bone of alveolar ridges. in Joint Event of the 11th Young Researchers’ Conference: Materials Science and Engineering and the 1st European Early Stage Researches’ Conference on Hydrogen Storage: Program and the Book of Abstracts. 2012;:103-103.
https://hdl.handle.net/21.15107/rcub_vinar_7454 .

Ajduković, Zorica, Ignjatović, Nenad L., Rajković, Jelena, Najman, Stevo, Mihailović, D., Petrović, N., Kenić Marinković, D., Uskoković, Dragan, "Bioactive composite materials in regeneration of the resorbed bone of alveolar ridges" in Joint Event of the 11th Young Researchers’ Conference: Materials Science and Engineering and the 1st European Early Stage Researches’ Conference on Hydrogen Storage: Program and the Book of Abstracts (2012):103-103,
https://hdl.handle.net/21.15107/rcub_vinar_7454 .

TY  - CONF
AU  - Stojanović, S.
AU  - Najman, Stevo
AU  - Ajduković, Zorica
AU  - Ignjatović, Nenad L.
AU  - Uskoković, Dragan
PY  - 2012
UR  - http://dais.sanu.ac.rs/123456789/458
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/7445
AB  - The aim of this study was to compare the effects of two types of nanomaterials, cobalt-exchanged hydroxyapatite (CoHAp) and calcium phosphate/poly-(DL-lactide-co-glycolide) (CP/PLGA), on the viability of Saos-2 osteoblast-like cells, using MTT test. We have examined the suspension of this materials in the following concentrations: 1.6, 8, 40, 200, 1000 and 2500 μg/ml, as well as extracts in concentration range from 2,5% to 100%. Both materials showed cytotoxic effect at higher concentrations of suspension and extract, respectively, but they were not cytotoxic at lower concentrations. CP/PLGA acted stronger cytotoxic compared to CoHAp, regardless of whether it is examined suspension or extract. CoHAp in small concentrations of suspension and extract acted slightly stimulatory on cells. This suggests that CoHAp may have advantage for use in the in vivo systems.
PB  - Belgrade : Materials Research Society of Serbia
C3  - The Fourteenth Annual Conference YUCOMAT 2012: Programme and the Book of Abstracts
T1  - Comparative study of the effects of different nanomaterials on the viability of human osteoblast-like cells
SP  - 126
EP  - 126
UR  - https://hdl.handle.net/21.15107/rcub_vinar_7445
ER  - 

@conference{
author = "Stojanović, S. and Najman, Stevo and Ajduković, Zorica and Ignjatović, Nenad L. and Uskoković, Dragan",
year = "2012",
abstract = "The aim of this study was to compare the effects of two types of nanomaterials, cobalt-exchanged hydroxyapatite (CoHAp) and calcium phosphate/poly-(DL-lactide-co-glycolide) (CP/PLGA), on the viability of Saos-2 osteoblast-like cells, using MTT test. We have examined the suspension of this materials in the following concentrations: 1.6, 8, 40, 200, 1000 and 2500 μg/ml, as well as extracts in concentration range from 2,5% to 100%. Both materials showed cytotoxic effect at higher concentrations of suspension and extract, respectively, but they were not cytotoxic at lower concentrations. CP/PLGA acted stronger cytotoxic compared to CoHAp, regardless of whether it is examined suspension or extract. CoHAp in small concentrations of suspension and extract acted slightly stimulatory on cells. This suggests that CoHAp may have advantage for use in the in vivo systems.",
publisher = "Belgrade : Materials Research Society of Serbia",
journal = "The Fourteenth Annual Conference YUCOMAT 2012: Programme and the Book of Abstracts",
title = "Comparative study of the effects of different nanomaterials on the viability of human osteoblast-like cells",
pages = "126-126",
url = "https://hdl.handle.net/21.15107/rcub_vinar_7445"
}

Stojanović, S., Najman, S., Ajduković, Z., Ignjatović, N. L.,& Uskoković, D.. (2012). Comparative study of the effects of different nanomaterials on the viability of human osteoblast-like cells. in The Fourteenth Annual Conference YUCOMAT 2012: Programme and the Book of Abstracts
Belgrade : Materials Research Society of Serbia., 126-126.
https://hdl.handle.net/21.15107/rcub_vinar_7445

Stojanović S, Najman S, Ajduković Z, Ignjatović NL, Uskoković D. Comparative study of the effects of different nanomaterials on the viability of human osteoblast-like cells. in The Fourteenth Annual Conference YUCOMAT 2012: Programme and the Book of Abstracts. 2012;:126-126.
https://hdl.handle.net/21.15107/rcub_vinar_7445 .

Stojanović, S., Najman, Stevo, Ajduković, Zorica, Ignjatović, Nenad L., Uskoković, Dragan, "Comparative study of the effects of different nanomaterials on the viability of human osteoblast-like cells" in The Fourteenth Annual Conference YUCOMAT 2012: Programme and the Book of Abstracts (2012):126-126,
https://hdl.handle.net/21.15107/rcub_vinar_7445 .

TY  - JOUR
AU  - Vukelić, Marija
AU  - Mitić, Žarko
AU  - Miljković, Miroslav
AU  - Živković, Jelena
AU  - Ignjatović, Nenad L.
AU  - Uskoković, Dragan
AU  - Živanov Čurlis, Jelena
AU  - Vasiljević, Perica
AU  - Najman, Stevo
PY  - 2012
UR  - http://dais.sanu.ac.rs/123456789/489
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/7451
AB  - Simulated body fluid (SBF) is an artificial fluid which has ionic composition and ionic concentration similar to human blood plasma. Purpose: This paper compares the interaction between the nanomaterial containing calcium phosphate/poly-dl-lactide-co-glycolide (N-CP/PLGA) and SBF, in order to investigate whether and to what extent inorganic ionic composition of human blood plasma leads to the aforementioned changes in the material. Methods: N-CP/PLGA was incubated for 1, 2, 3, and 5 weeks in SBF. The surface of the material was analyzed on SEM-EDS and FTIR spectrometer, while SBF was subjected to pH and electrical conductivity measurement. Results: Our results indicate that dissolution of the polymer component of the material N-CP/PLGA and precipitation of the material similar to hydroxyapatite on its surface are based on the morphologic changes seen in this material. Conclusions: The mechanism of the apatite formation on the bioceramic surface was intensively studied and was considered crucial in designing the new biomaterials. The results obtained in this work indicate that N-CP/PLGA may be a good candidate for application to bone regeneration.
PB  - Milano : Wichtig Publishing
T2  - Journal of Applied Biomaterials and Functional Materials
T1  - Apatite formation on nanomaterial calcium phosphate/poly-DL-lactide-co-glycolide in simulated body fluid
SP  - 43
EP  - 48
DO  - 10.5301/JABFM.2012.9274
ER  - 

@article{
author = "Vukelić, Marija and Mitić, Žarko and Miljković, Miroslav and Živković, Jelena and Ignjatović, Nenad L. and Uskoković, Dragan and Živanov Čurlis, Jelena and Vasiljević, Perica and Najman, Stevo",
year = "2012",
abstract = "Simulated body fluid (SBF) is an artificial fluid which has ionic composition and ionic concentration similar to human blood plasma. Purpose: This paper compares the interaction between the nanomaterial containing calcium phosphate/poly-dl-lactide-co-glycolide (N-CP/PLGA) and SBF, in order to investigate whether and to what extent inorganic ionic composition of human blood plasma leads to the aforementioned changes in the material. Methods: N-CP/PLGA was incubated for 1, 2, 3, and 5 weeks in SBF. The surface of the material was analyzed on SEM-EDS and FTIR spectrometer, while SBF was subjected to pH and electrical conductivity measurement. Results: Our results indicate that dissolution of the polymer component of the material N-CP/PLGA and precipitation of the material similar to hydroxyapatite on its surface are based on the morphologic changes seen in this material. Conclusions: The mechanism of the apatite formation on the bioceramic surface was intensively studied and was considered crucial in designing the new biomaterials. The results obtained in this work indicate that N-CP/PLGA may be a good candidate for application to bone regeneration.",
publisher = "Milano : Wichtig Publishing",
journal = "Journal of Applied Biomaterials and Functional Materials",
title = "Apatite formation on nanomaterial calcium phosphate/poly-DL-lactide-co-glycolide in simulated body fluid",
pages = "43-48",
doi = "10.5301/JABFM.2012.9274"
}

Vukelić, M., Mitić, Ž., Miljković, M., Živković, J., Ignjatović, N. L., Uskoković, D., Živanov Čurlis, J., Vasiljević, P.,& Najman, S.. (2012). Apatite formation on nanomaterial calcium phosphate/poly-DL-lactide-co-glycolide in simulated body fluid. in Journal of Applied Biomaterials and Functional Materials
Milano : Wichtig Publishing., 43-48.
https://doi.org/10.5301/JABFM.2012.9274

Vukelić M, Mitić Ž, Miljković M, Živković J, Ignjatović NL, Uskoković D, Živanov Čurlis J, Vasiljević P, Najman S. Apatite formation on nanomaterial calcium phosphate/poly-DL-lactide-co-glycolide in simulated body fluid. in Journal of Applied Biomaterials and Functional Materials. 2012;:43-48.
doi:10.5301/JABFM.2012.9274 .

Vukelić, Marija, Mitić, Žarko, Miljković, Miroslav, Živković, Jelena, Ignjatović, Nenad L., Uskoković, Dragan, Živanov Čurlis, Jelena, Vasiljević, Perica, Najman, Stevo, "Apatite formation on nanomaterial calcium phosphate/poly-DL-lactide-co-glycolide in simulated body fluid" in Journal of Applied Biomaterials and Functional Materials (2012):43-48,
https://doi.org/10.5301/JABFM.2012.9274 . .

TY  - CONF
AU  - Ajduković, Zorica
AU  - Ignjatović, Nenad L.
AU  - Savić, Vojin
AU  - Najman, Stevo
AU  - Mihailović, D.
AU  - Rajković, J.
AU  - Petrović, N.
AU  - Uskoković, Dragan
PY  - 2012
UR  - http://dais.sanu.ac.rs/123456789/455
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/7444
AB  - In recent years, calcium hydroxyapatite (HAp) and its substituents are increasingly used in dentistry and medicine. The influence of nanoparticles Ca / Co-HAp in strengthening weak osteoporotic bone jaw tegmenta was tested in an experimental model. The study was conducted on Wistar soy rats, aged 6-8 weeks. The biomaterial was implanted in the osteoporoticly weakened mandible of these animals. The best results in the strengthening of the lower jaw bone tegmenta were achieved 24 weeks after implantation of hydroxyapatite nanoparticles in which the calcium ion was substituted with 12% of cobalt ions. Histochemical parameters of bone synthesis were in a statistically significant increase. SEM analysis showed a high degree of osteogenetic ability of nano-particulate material implanted in the bone defect.
PB  - Belgrade : Materials Research Society of Serbia
C3  - The Fourteenth Annual Conference YUCOMAT 2012: Programme and the Book of Abstracts
T1  - Hydroxyapatite and hydroxyapatite substituents in strengthening of the jaw bone tegmenta
SP  - 121
EP  - 121
UR  - https://hdl.handle.net/21.15107/rcub_vinar_7444
ER  - 

@conference{
author = "Ajduković, Zorica and Ignjatović, Nenad L. and Savić, Vojin and Najman, Stevo and Mihailović, D. and Rajković, J. and Petrović, N. and Uskoković, Dragan",
year = "2012",
abstract = "In recent years, calcium hydroxyapatite (HAp) and its substituents are increasingly used in dentistry and medicine. The influence of nanoparticles Ca / Co-HAp in strengthening weak osteoporotic bone jaw tegmenta was tested in an experimental model. The study was conducted on Wistar soy rats, aged 6-8 weeks. The biomaterial was implanted in the osteoporoticly weakened mandible of these animals. The best results in the strengthening of the lower jaw bone tegmenta were achieved 24 weeks after implantation of hydroxyapatite nanoparticles in which the calcium ion was substituted with 12% of cobalt ions. Histochemical parameters of bone synthesis were in a statistically significant increase. SEM analysis showed a high degree of osteogenetic ability of nano-particulate material implanted in the bone defect.",
publisher = "Belgrade : Materials Research Society of Serbia",
journal = "The Fourteenth Annual Conference YUCOMAT 2012: Programme and the Book of Abstracts",
title = "Hydroxyapatite and hydroxyapatite substituents in strengthening of the jaw bone tegmenta",
pages = "121-121",
url = "https://hdl.handle.net/21.15107/rcub_vinar_7444"
}

Ajduković, Z., Ignjatović, N. L., Savić, V., Najman, S., Mihailović, D., Rajković, J., Petrović, N.,& Uskoković, D.. (2012). Hydroxyapatite and hydroxyapatite substituents in strengthening of the jaw bone tegmenta. in The Fourteenth Annual Conference YUCOMAT 2012: Programme and the Book of Abstracts
Belgrade : Materials Research Society of Serbia., 121-121.
https://hdl.handle.net/21.15107/rcub_vinar_7444

Ajduković Z, Ignjatović NL, Savić V, Najman S, Mihailović D, Rajković J, Petrović N, Uskoković D. Hydroxyapatite and hydroxyapatite substituents in strengthening of the jaw bone tegmenta. in The Fourteenth Annual Conference YUCOMAT 2012: Programme and the Book of Abstracts. 2012;:121-121.
https://hdl.handle.net/21.15107/rcub_vinar_7444 .

Ajduković, Zorica, Ignjatović, Nenad L., Savić, Vojin, Najman, Stevo, Mihailović, D., Rajković, J., Petrović, N., Uskoković, Dragan, "Hydroxyapatite and hydroxyapatite substituents in strengthening of the jaw bone tegmenta" in The Fourteenth Annual Conference YUCOMAT 2012: Programme and the Book of Abstracts (2012):121-121,
https://hdl.handle.net/21.15107/rcub_vinar_7444 .

TY  - CONF
AU  - Najman, Stevo
AU  - Stojanović, Sanja
AU  - Najdanović, Jelena
AU  - Ignjatović, Nenad L.
AU  - Uskoković, Dragan
PY  - 2011
UR  - http://dais.sanu.ac.rs/123456789/698
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/7519
AB  - The aim of this study was to examine the effects of nanoparticles of calcium phosphate/poly-(DL-lactide-co-glycolide) (NPs-CP/PLGA) on viability and growth of different cell lines in vitro. HeLa and MDCK cells were incubated with different concentrations of suspension and extract of NPs-CP/PLGA. Concentrations of suspension were in the range from 1.6 μg/ml to 5000 μg/ml and extract in the range from 2.5% to 50%. After incubation, MTT test was performed. Our results indicate that examined nanomaterial shows different effects depending on type of the cells, applied concentration of nanomaterial as well as whether it is examined suspension or extract.
PB  - Belgrade : Institute of Technical Sciences of SASA
C3  - Program and the Book of Abstracts / Tenth Young Researchers' Conference Materials Science and Engineering, December 21-23, 2011, Belgrade, Serbia
T1  - Assessment of the effects of nanoparticles of CP/PLGA on cultures of different cell lines
SP  - 6
EP  - 6
UR  - https://hdl.handle.net/21.15107/rcub_vinar_7519
ER  - 

@conference{
author = "Najman, Stevo and Stojanović, Sanja and Najdanović, Jelena and Ignjatović, Nenad L. and Uskoković, Dragan",
year = "2011",
abstract = "The aim of this study was to examine the effects of nanoparticles of calcium phosphate/poly-(DL-lactide-co-glycolide) (NPs-CP/PLGA) on viability and growth of different cell lines in vitro. HeLa and MDCK cells were incubated with different concentrations of suspension and extract of NPs-CP/PLGA. Concentrations of suspension were in the range from 1.6 μg/ml to 5000 μg/ml and extract in the range from 2.5% to 50%. After incubation, MTT test was performed. Our results indicate that examined nanomaterial shows different effects depending on type of the cells, applied concentration of nanomaterial as well as whether it is examined suspension or extract.",
publisher = "Belgrade : Institute of Technical Sciences of SASA",
journal = "Program and the Book of Abstracts / Tenth Young Researchers' Conference Materials Science and Engineering, December 21-23, 2011, Belgrade, Serbia",
title = "Assessment of the effects of nanoparticles of CP/PLGA on cultures of different cell lines",
pages = "6-6",
url = "https://hdl.handle.net/21.15107/rcub_vinar_7519"
}

Najman, S., Stojanović, S., Najdanović, J., Ignjatović, N. L.,& Uskoković, D.. (2011). Assessment of the effects of nanoparticles of CP/PLGA on cultures of different cell lines. in Program and the Book of Abstracts / Tenth Young Researchers' Conference Materials Science and Engineering, December 21-23, 2011, Belgrade, Serbia
Belgrade : Institute of Technical Sciences of SASA., 6-6.
https://hdl.handle.net/21.15107/rcub_vinar_7519

Najman S, Stojanović S, Najdanović J, Ignjatović NL, Uskoković D. Assessment of the effects of nanoparticles of CP/PLGA on cultures of different cell lines. in Program and the Book of Abstracts / Tenth Young Researchers' Conference Materials Science and Engineering, December 21-23, 2011, Belgrade, Serbia. 2011;:6-6.
https://hdl.handle.net/21.15107/rcub_vinar_7519 .

Najman, Stevo, Stojanović, Sanja, Najdanović, Jelena, Ignjatović, Nenad L., Uskoković, Dragan, "Assessment of the effects of nanoparticles of CP/PLGA on cultures of different cell lines" in Program and the Book of Abstracts / Tenth Young Researchers' Conference Materials Science and Engineering, December 21-23, 2011, Belgrade, Serbia (2011):6-6,
https://hdl.handle.net/21.15107/rcub_vinar_7519 .

TY  - CONF
AU  - Ajduković, Zorica
AU  - Petrović, Milica B.
AU  - Milićević, J.
AU  - Đorđević, N.
AU  - Ignjatović, Nenad L.
AU  - Savić, Vojin
AU  - Najman, Stevo
AU  - Mihailović, Dragan
AU  - Vasiljević, P.
AU  - Uskoković, Dragan
PY  - 2011
UR  - http://dais.sanu.ac.rs/123456789/674
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/7505
AB  - One of the trends in the treatment of reduced bone density is in oral implantology through the use of new biomaterials with paramagnetic properties. In this in vivo study the effect of Ca /Co-HAp nanoparticles (calcium/cobalt-hydroxiapatite) in the regeneration of the reduced alveolar bone density in experimental animals was examined by analyzing both the biochemical and histochemical markers and through analysis of alveolar bone density. The research was carried out on female Westar rats, aged 6-8 weeks, whom have been implanted nanobiomaterial in reduced alveolar bone density. Good results in regeneration of reduced bone density were achieved in six weeks after implantation of the nanoparticles with paramagnetic properties. Biochemical markers of osteogenesis showed statistically significant rise. Histological analysis revealed high level reparatory skills of the biocomposite implanted in the bone defect, while X-ray analyses evidenced rise of bone density. Implantation of Ca/Co-Hap enables rapid new formation, thus becoming the material of choice for accelerated reduced bone density regeneration.
PB  - Belgrade : Materials Research Society of Serbia
C3  - The Thirteenth Annual Conference YUCOMAT 2011: Programme and the Book of Abstracts
T1  - Paramagnetic nanoparticles in the regeneration of the reduced alveolar bone density
SP  - 161
EP  - 161
UR  - https://hdl.handle.net/21.15107/rcub_vinar_7505
ER  - 

@conference{
author = "Ajduković, Zorica and Petrović, Milica B. and Milićević, J. and Đorđević, N. and Ignjatović, Nenad L. and Savić, Vojin and Najman, Stevo and Mihailović, Dragan and Vasiljević, P. and Uskoković, Dragan",
year = "2011",
abstract = "One of the trends in the treatment of reduced bone density is in oral implantology through the use of new biomaterials with paramagnetic properties. In this in vivo study the effect of Ca /Co-HAp nanoparticles (calcium/cobalt-hydroxiapatite) in the regeneration of the reduced alveolar bone density in experimental animals was examined by analyzing both the biochemical and histochemical markers and through analysis of alveolar bone density. The research was carried out on female Westar rats, aged 6-8 weeks, whom have been implanted nanobiomaterial in reduced alveolar bone density. Good results in regeneration of reduced bone density were achieved in six weeks after implantation of the nanoparticles with paramagnetic properties. Biochemical markers of osteogenesis showed statistically significant rise. Histological analysis revealed high level reparatory skills of the biocomposite implanted in the bone defect, while X-ray analyses evidenced rise of bone density. Implantation of Ca/Co-Hap enables rapid new formation, thus becoming the material of choice for accelerated reduced bone density regeneration.",
publisher = "Belgrade : Materials Research Society of Serbia",
journal = "The Thirteenth Annual Conference YUCOMAT 2011: Programme and the Book of Abstracts",
title = "Paramagnetic nanoparticles in the regeneration of the reduced alveolar bone density",
pages = "161-161",
url = "https://hdl.handle.net/21.15107/rcub_vinar_7505"
}

Ajduković, Z., Petrović, M. B., Milićević, J., Đorđević, N., Ignjatović, N. L., Savić, V., Najman, S., Mihailović, D., Vasiljević, P.,& Uskoković, D.. (2011). Paramagnetic nanoparticles in the regeneration of the reduced alveolar bone density. in The Thirteenth Annual Conference YUCOMAT 2011: Programme and the Book of Abstracts
Belgrade : Materials Research Society of Serbia., 161-161.
https://hdl.handle.net/21.15107/rcub_vinar_7505

Ajduković Z, Petrović MB, Milićević J, Đorđević N, Ignjatović NL, Savić V, Najman S, Mihailović D, Vasiljević P, Uskoković D. Paramagnetic nanoparticles in the regeneration of the reduced alveolar bone density. in The Thirteenth Annual Conference YUCOMAT 2011: Programme and the Book of Abstracts. 2011;:161-161.
https://hdl.handle.net/21.15107/rcub_vinar_7505 .

Ajduković, Zorica, Petrović, Milica B., Milićević, J., Đorđević, N., Ignjatović, Nenad L., Savić, Vojin, Najman, Stevo, Mihailović, Dragan, Vasiljević, P., Uskoković, Dragan, "Paramagnetic nanoparticles in the regeneration of the reduced alveolar bone density" in The Thirteenth Annual Conference YUCOMAT 2011: Programme and the Book of Abstracts (2011):161-161,
https://hdl.handle.net/21.15107/rcub_vinar_7505 .