TY  - JOUR
AU  - Gavrilović, Ljubica
AU  - Popović, Nataša M.
AU  - Stojiljković, Vesna
AU  - Pejić, Snežana
AU  - Todorović, Ana
AU  - Pavlović, Ivan
AU  - Pantelić, Marija
AU  - Pajović, Snežana B.
PY  - 2021
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/9959
AB  - Data about the dynamics of noradrenaline (NA) transmission, storage and degradation may be very important for understanding the reduction of functional deficiency of NA and maintaining the stability of NA levels in animals with depressive-like behavior treated with lithium. This study aimed to investigate the effects of mood stabilizer lithium on concentrations of NA in the prefrontal cortex (PFC), as well as behavior rats exposed to chronic restraint stress (CRS). In addition, this study examined the effects of lithium on protein levels of noradrenaline transporter (NET), vesicular monoamine transporter 2 (VMAT2) and catechol-O-methyltransferase (COMT), as well as the enzyme activity of monoamine oxidase A (MOA) in the PFC of chronically stressed rats. METHODS: The investigated parameters were quantified by Western blot analysis, CAT Research ELISA kits, and an assay of enzyme activity. Also, the forced swim test (FST) was used to assess the behavior of animals. RESULTS: We found that lithium treatment decreased high protein levels of NET and VMAT2, as well as the enzyme activity of MOA in chronically stressed rats to the levels found in unstressed animals. In addition, lithium treatment decreased the concentration of NA (24%) and immobility in animals exposed to CRS. CONCLUSION: Our data confirm that lithium-induced modulation of prefrontal noradrenergic turnover and stabilized the behavior of chronically stressed rats.
T2  - Neuroendocrinology Letters
T1  - Effects of mood stabilizer lithium on noradrenergic turnover in the prefrontal cortex of chronically stressed rats
VL  - 42
IS  - 3
SP  - 171
EP  - 176
UR  - https://hdl.handle.net/21.15107/rcub_vinar_9959
ER  - 

@article{
author = "Gavrilović, Ljubica and Popović, Nataša M. and Stojiljković, Vesna and Pejić, Snežana and Todorović, Ana and Pavlović, Ivan and Pantelić, Marija and Pajović, Snežana B.",
year = "2021",
abstract = "Data about the dynamics of noradrenaline (NA) transmission, storage and degradation may be very important for understanding the reduction of functional deficiency of NA and maintaining the stability of NA levels in animals with depressive-like behavior treated with lithium. This study aimed to investigate the effects of mood stabilizer lithium on concentrations of NA in the prefrontal cortex (PFC), as well as behavior rats exposed to chronic restraint stress (CRS). In addition, this study examined the effects of lithium on protein levels of noradrenaline transporter (NET), vesicular monoamine transporter 2 (VMAT2) and catechol-O-methyltransferase (COMT), as well as the enzyme activity of monoamine oxidase A (MOA) in the PFC of chronically stressed rats. METHODS: The investigated parameters were quantified by Western blot analysis, CAT Research ELISA kits, and an assay of enzyme activity. Also, the forced swim test (FST) was used to assess the behavior of animals. RESULTS: We found that lithium treatment decreased high protein levels of NET and VMAT2, as well as the enzyme activity of MOA in chronically stressed rats to the levels found in unstressed animals. In addition, lithium treatment decreased the concentration of NA (24%) and immobility in animals exposed to CRS. CONCLUSION: Our data confirm that lithium-induced modulation of prefrontal noradrenergic turnover and stabilized the behavior of chronically stressed rats.",
journal = "Neuroendocrinology Letters",
title = "Effects of mood stabilizer lithium on noradrenergic turnover in the prefrontal cortex of chronically stressed rats",
volume = "42",
number = "3",
pages = "171-176",
url = "https://hdl.handle.net/21.15107/rcub_vinar_9959"
}

Gavrilović, L., Popović, N. M., Stojiljković, V., Pejić, S., Todorović, A., Pavlović, I., Pantelić, M.,& Pajović, S. B.. (2021). Effects of mood stabilizer lithium on noradrenergic turnover in the prefrontal cortex of chronically stressed rats. in Neuroendocrinology Letters, 42(3), 171-176.
https://hdl.handle.net/21.15107/rcub_vinar_9959

Gavrilović L, Popović NM, Stojiljković V, Pejić S, Todorović A, Pavlović I, Pantelić M, Pajović SB. Effects of mood stabilizer lithium on noradrenergic turnover in the prefrontal cortex of chronically stressed rats. in Neuroendocrinology Letters. 2021;42(3):171-176.
https://hdl.handle.net/21.15107/rcub_vinar_9959 .

Gavrilović, Ljubica, Popović, Nataša M., Stojiljković, Vesna, Pejić, Snežana, Todorović, Ana, Pavlović, Ivan, Pantelić, Marija, Pajović, Snežana B., "Effects of mood stabilizer lithium on noradrenergic turnover in the prefrontal cortex of chronically stressed rats" in Neuroendocrinology Letters, 42, no. 3 (2021):171-176,
https://hdl.handle.net/21.15107/rcub_vinar_9959 .

TY  - JOUR
AU  - Glumac, Sofija
AU  - Davidović, Radoslav S.
AU  - Dožić, Branko
AU  - Hinić, Sasa
AU  - Pavlović, Ivan
AU  - Drakulić, Dunja R.
AU  - Todorović, Ana
AU  - Medojević Pavlović, Maja
AU  - Radojević-Škodrić, Sanja
AU  - Baralić, Ivana
AU  - Sopta, Jelena
AU  - Pejić, Snežana
PY  - 2021
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/9887
AB  - Rhabdomyosarcoma (RMS) is a highly malignant cancer and is the most common soft tissue sarcoma in children and adolescents, but it is rare in adults (<1% of all adult malignancies). Altered expression and molecular abnormalities of cell-cycle-regulatory proteins are one of the most prominent features in RMS. Therefore, we evaluated the expression of cyclin-dependent kinase inhibitors p57 and p16, as well as p16 methylation status, along with clinicopathological characteristics and overall survival (OS) in RMS patients. This analysis was conducted on 23 pediatric and 44 adult patients. There was a male predominance in both groups and extremities were the most frequent tumor site. In adults, alveolar and pleomorphic types were almost equally represented. The majority of pediatric tumors were low grade, whereas, in adults, only one patient had a low-grade tumor. Seven pediatric (30.43%) and eight adult (18.18%) patients had a low p16 expression. The analysis of methylation status of the p16 promoter showed the presence of methylated allele only in one sample with pleomorphic histology. Six (26.1%) pediatric and 15 (34.1%) adult patients had low p57 expression, while in 17 (73.9%) pediatric and 29 (65.9%) adult patients it was assessed as high. Ninetyone percent of the pediatric patients and 32.6% of adults were alive at the end of the observational period. In adults, significant associations were found between OS and age (P = 0.020), gender (P = 0.027), tumor size (P < 0.001), lymph node status (P < 0.001), presence of metastases (P = 0.015), and p57 expression (P = 0.039). Stratification by histological type showed the correlation of low p57 expression (P = 0.030) and worse OS of patients with alveolar RMS. Univariate analysis identified age > 50 yrs. (HR 2.447), tumors > 5 cm (HR 21.31), involvement of regional lymph nodes (HR 3.96), the presence of metastases (HR 2.53), and low p57 expression (HR 2.11) as predictors of lower OS. Tumor size, regional lymph nodes involvement, and metastases were the independent predictors after multivariate analysis, while p57 did not predict OS in an independent way. In summary, although p57 was not confirmed to be an independent predictor of OS, our results indicate that its low expression may be the marker of aggressive phenotype and poor prognosis in adult RMS patients. Also, our findings suggest that epigenetic inactivation of p16 is not important in the pathogenesis of rhabdomyosarcoma.
T2  - Pathology - Research and Practice
T1  - Immunohistochemical expression of cyclin-dependent kinase inhibitors p16 and p57 in rhabdomyosarcoma
VL  - 225
SP  - 153558
DO  - 10.1016/j.prp.2021.153558
ER  - 

@article{
author = "Glumac, Sofija and Davidović, Radoslav S. and Dožić, Branko and Hinić, Sasa and Pavlović, Ivan and Drakulić, Dunja R. and Todorović, Ana and Medojević Pavlović, Maja and Radojević-Škodrić, Sanja and Baralić, Ivana and Sopta, Jelena and Pejić, Snežana",
year = "2021",
abstract = "Rhabdomyosarcoma (RMS) is a highly malignant cancer and is the most common soft tissue sarcoma in children and adolescents, but it is rare in adults (<1% of all adult malignancies). Altered expression and molecular abnormalities of cell-cycle-regulatory proteins are one of the most prominent features in RMS. Therefore, we evaluated the expression of cyclin-dependent kinase inhibitors p57 and p16, as well as p16 methylation status, along with clinicopathological characteristics and overall survival (OS) in RMS patients. This analysis was conducted on 23 pediatric and 44 adult patients. There was a male predominance in both groups and extremities were the most frequent tumor site. In adults, alveolar and pleomorphic types were almost equally represented. The majority of pediatric tumors were low grade, whereas, in adults, only one patient had a low-grade tumor. Seven pediatric (30.43%) and eight adult (18.18%) patients had a low p16 expression. The analysis of methylation status of the p16 promoter showed the presence of methylated allele only in one sample with pleomorphic histology. Six (26.1%) pediatric and 15 (34.1%) adult patients had low p57 expression, while in 17 (73.9%) pediatric and 29 (65.9%) adult patients it was assessed as high. Ninetyone percent of the pediatric patients and 32.6% of adults were alive at the end of the observational period. In adults, significant associations were found between OS and age (P = 0.020), gender (P = 0.027), tumor size (P < 0.001), lymph node status (P < 0.001), presence of metastases (P = 0.015), and p57 expression (P = 0.039). Stratification by histological type showed the correlation of low p57 expression (P = 0.030) and worse OS of patients with alveolar RMS. Univariate analysis identified age > 50 yrs. (HR 2.447), tumors > 5 cm (HR 21.31), involvement of regional lymph nodes (HR 3.96), the presence of metastases (HR 2.53), and low p57 expression (HR 2.11) as predictors of lower OS. Tumor size, regional lymph nodes involvement, and metastases were the independent predictors after multivariate analysis, while p57 did not predict OS in an independent way. In summary, although p57 was not confirmed to be an independent predictor of OS, our results indicate that its low expression may be the marker of aggressive phenotype and poor prognosis in adult RMS patients. Also, our findings suggest that epigenetic inactivation of p16 is not important in the pathogenesis of rhabdomyosarcoma.",
journal = "Pathology - Research and Practice",
title = "Immunohistochemical expression of cyclin-dependent kinase inhibitors p16 and p57 in rhabdomyosarcoma",
volume = "225",
pages = "153558",
doi = "10.1016/j.prp.2021.153558"
}

Glumac, S., Davidović, R. S., Dožić, B., Hinić, S., Pavlović, I., Drakulić, D. R., Todorović, A., Medojević Pavlović, M., Radojević-Škodrić, S., Baralić, I., Sopta, J.,& Pejić, S.. (2021). Immunohistochemical expression of cyclin-dependent kinase inhibitors p16 and p57 in rhabdomyosarcoma. in Pathology - Research and Practice, 225, 153558.
https://doi.org/10.1016/j.prp.2021.153558

Glumac S, Davidović RS, Dožić B, Hinić S, Pavlović I, Drakulić DR, Todorović A, Medojević Pavlović M, Radojević-Škodrić S, Baralić I, Sopta J, Pejić S. Immunohistochemical expression of cyclin-dependent kinase inhibitors p16 and p57 in rhabdomyosarcoma. in Pathology - Research and Practice. 2021;225:153558.
doi:10.1016/j.prp.2021.153558 .

Glumac, Sofija, Davidović, Radoslav S., Dožić, Branko, Hinić, Sasa, Pavlović, Ivan, Drakulić, Dunja R., Todorović, Ana, Medojević Pavlović, Maja, Radojević-Škodrić, Sanja, Baralić, Ivana, Sopta, Jelena, Pejić, Snežana, "Immunohistochemical expression of cyclin-dependent kinase inhibitors p16 and p57 in rhabdomyosarcoma" in Pathology - Research and Practice, 225 (2021):153558,
https://doi.org/10.1016/j.prp.2021.153558 . .

TY  - JOUR
AU  - Pavlović, Ivan
AU  - Pejić, Snežana
AU  - Radojević-Škodrić, Sanja
AU  - Todorović, Ana
AU  - Stojiljković, Vesna
AU  - Gavrilović, Ljubica
AU  - Popović, Nataša M.
AU  - Basta-Jovanović, Gordana
AU  - Džamić, Zoran
AU  - Pajović, Snežana B.
PY  - 2020
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/8405
AB  - Introduction The oxidative stress contributes to all three phases of carcinogenesis and represents a concomitant condition in renal cell carcinoma (RCC). RCC is the most common type of neoplasm of the kidney, and despite numerous studies the set of predictive and prognostic markers of survival are still unknown. The aim of our study was to examine the relation between antioxidant (AO) status and overall survival (OS) in RCC patients.  Material and methods Our study included 95 patients with RCC, who underwent radical nephrectomy. We analysed the prognostic role of antioxidant enzymes (superoxide dismutase, catalase, glutathione peroxidase, glutathione S-transferase, glutathione reductase, glutathione, and malondialde-hyde) and other clinicopathological factors (size, grade, stage, and histological subtype) on the OS of RCC patients.  Results The 5-year OS was 54.6%. The survival analysis related to AO parameters showed no significant difference in survival of RCC patients. The concentration of malondialdehyde, an indicator of lipid peroxidation, also had no significant effect on the survival rate of RCC pa-tients. Univariate and multivariate analysis confirmed the significance of clinicopathological parameters (size, p < 0.001; Fuhrman grade, p = 0.001, and stage, p < 0.001) for patients’ survival.  Conclusions In our cohort of patients, different antioxidant parameters were not found to be predictors for OS of patients with RCC, who underwent radical nephrectomy.
T2  - Archives of Medical Science
T1  - The effect of antioxidant status on overall survival in renal cell carcinoma
VL  - 16
IS  - 1
SP  - 94
EP  - 101
DO  - 10.5114/aoms.2019.86818
ER  - 

@article{
author = "Pavlović, Ivan and Pejić, Snežana and Radojević-Škodrić, Sanja and Todorović, Ana and Stojiljković, Vesna and Gavrilović, Ljubica and Popović, Nataša M. and Basta-Jovanović, Gordana and Džamić, Zoran and Pajović, Snežana B.",
year = "2020",
abstract = "Introduction The oxidative stress contributes to all three phases of carcinogenesis and represents a concomitant condition in renal cell carcinoma (RCC). RCC is the most common type of neoplasm of the kidney, and despite numerous studies the set of predictive and prognostic markers of survival are still unknown. The aim of our study was to examine the relation between antioxidant (AO) status and overall survival (OS) in RCC patients.  Material and methods Our study included 95 patients with RCC, who underwent radical nephrectomy. We analysed the prognostic role of antioxidant enzymes (superoxide dismutase, catalase, glutathione peroxidase, glutathione S-transferase, glutathione reductase, glutathione, and malondialde-hyde) and other clinicopathological factors (size, grade, stage, and histological subtype) on the OS of RCC patients.  Results The 5-year OS was 54.6%. The survival analysis related to AO parameters showed no significant difference in survival of RCC patients. The concentration of malondialdehyde, an indicator of lipid peroxidation, also had no significant effect on the survival rate of RCC pa-tients. Univariate and multivariate analysis confirmed the significance of clinicopathological parameters (size, p < 0.001; Fuhrman grade, p = 0.001, and stage, p < 0.001) for patients’ survival.  Conclusions In our cohort of patients, different antioxidant parameters were not found to be predictors for OS of patients with RCC, who underwent radical nephrectomy.",
journal = "Archives of Medical Science",
title = "The effect of antioxidant status on overall survival in renal cell carcinoma",
volume = "16",
number = "1",
pages = "94-101",
doi = "10.5114/aoms.2019.86818"
}

Pavlović, I., Pejić, S., Radojević-Škodrić, S., Todorović, A., Stojiljković, V., Gavrilović, L., Popović, N. M., Basta-Jovanović, G., Džamić, Z.,& Pajović, S. B.. (2020). The effect of antioxidant status on overall survival in renal cell carcinoma. in Archives of Medical Science, 16(1), 94-101.
https://doi.org/10.5114/aoms.2019.86818

Pavlović I, Pejić S, Radojević-Škodrić S, Todorović A, Stojiljković V, Gavrilović L, Popović NM, Basta-Jovanović G, Džamić Z, Pajović SB. The effect of antioxidant status on overall survival in renal cell carcinoma. in Archives of Medical Science. 2020;16(1):94-101.
doi:10.5114/aoms.2019.86818 .

Pavlović, Ivan, Pejić, Snežana, Radojević-Škodrić, Sanja, Todorović, Ana, Stojiljković, Vesna, Gavrilović, Ljubica, Popović, Nataša M., Basta-Jovanović, Gordana, Džamić, Zoran, Pajović, Snežana B., "The effect of antioxidant status on overall survival in renal cell carcinoma" in Archives of Medical Science, 16, no. 1 (2020):94-101,
https://doi.org/10.5114/aoms.2019.86818 . .

TY  - JOUR
AU  - Gavrilović, Ljubica
AU  - Popović, Nataša M.
AU  - Stojiljković, Vesna
AU  - Pejić, Snežana
AU  - Todorović, Ana
AU  - Pavlović, Ivan
AU  - Pajović, Snežana B.
PY  - 2020
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/9617
AB  - This study aimed to investigate the effects of chronic restraint stress (CRS) on the protein levels of dopamine-β-hydroxylase (DBH), noradrenaline transporter (NET), vesicular monoamine transporter 2 (VMAT2) and brain-derived neurotrophic factor (BDNF), as well as the concentration of noradrenaline (NA) in the rat hippocampus. The investigated parameters were quantified by Western blot analyses and ELISA kits. We found that CRS increased the protein levels of DBH by 30 %, VMAT2 by 11 %, BDNF by 11 % and the concentration of NA by 104 %, but decreased the protein levels of NET by 16 % in the hippocampus of chronically stressed rats. The molecular mechanisms by which CRS increased the hippocampal NA level are an important adaptive phenomenon of the noradrenergic system in the stress condition. © 2020 Charles University. All rights reserved.
T2  - Folia Biologica (Czech Republic)
T1  - Changes of Hippocampal Noradrenergic Capacity in Stress Condition
VL  - 66
IS  - 2
SP  - 81
EP  - 84
UR  - https://hdl.handle.net/21.15107/rcub_vinar_9617
ER  - 

@article{
author = "Gavrilović, Ljubica and Popović, Nataša M. and Stojiljković, Vesna and Pejić, Snežana and Todorović, Ana and Pavlović, Ivan and Pajović, Snežana B.",
year = "2020",
abstract = "This study aimed to investigate the effects of chronic restraint stress (CRS) on the protein levels of dopamine-β-hydroxylase (DBH), noradrenaline transporter (NET), vesicular monoamine transporter 2 (VMAT2) and brain-derived neurotrophic factor (BDNF), as well as the concentration of noradrenaline (NA) in the rat hippocampus. The investigated parameters were quantified by Western blot analyses and ELISA kits. We found that CRS increased the protein levels of DBH by 30 %, VMAT2 by 11 %, BDNF by 11 % and the concentration of NA by 104 %, but decreased the protein levels of NET by 16 % in the hippocampus of chronically stressed rats. The molecular mechanisms by which CRS increased the hippocampal NA level are an important adaptive phenomenon of the noradrenergic system in the stress condition. © 2020 Charles University. All rights reserved.",
journal = "Folia Biologica (Czech Republic)",
title = "Changes of Hippocampal Noradrenergic Capacity in Stress Condition",
volume = "66",
number = "2",
pages = "81-84",
url = "https://hdl.handle.net/21.15107/rcub_vinar_9617"
}

Gavrilović, L., Popović, N. M., Stojiljković, V., Pejić, S., Todorović, A., Pavlović, I.,& Pajović, S. B.. (2020). Changes of Hippocampal Noradrenergic Capacity in Stress Condition. in Folia Biologica (Czech Republic), 66(2), 81-84.
https://hdl.handle.net/21.15107/rcub_vinar_9617

Gavrilović L, Popović NM, Stojiljković V, Pejić S, Todorović A, Pavlović I, Pajović SB. Changes of Hippocampal Noradrenergic Capacity in Stress Condition. in Folia Biologica (Czech Republic). 2020;66(2):81-84.
https://hdl.handle.net/21.15107/rcub_vinar_9617 .

Gavrilović, Ljubica, Popović, Nataša M., Stojiljković, Vesna, Pejić, Snežana, Todorović, Ana, Pavlović, Ivan, Pajović, Snežana B., "Changes of Hippocampal Noradrenergic Capacity in Stress Condition" in Folia Biologica (Czech Republic), 66, no. 2 (2020):81-84,
https://hdl.handle.net/21.15107/rcub_vinar_9617 .

TY  - JOUR
AU  - Popović, Nataša M.
AU  - Stojiljković, Vesna
AU  - Pejić, Snežana
AU  - Todorović, Ana
AU  - Pavlović, Ivan
AU  - Gavrilović, Ljubica
AU  - Pajović, Snežana B.
PY  - 2019
UR  - https://www.hindawi.com/journals/omcl/2019/8745376/
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/8085
AB  - This study examined the effects of lithium on gene expression and activity of the antioxidant enzymes copper zinc superoxide dismutase (SOD1), manganese superoxide dismutase (SOD2), catalase (CAT), glutathione peroxidase (GPx), and glutathione reductase (GR) in the hippocampus of chronically stressed rats. In addition, we examined the effects of lithium on anxiety behaviors, hippocampal concentrations of dopamine (DA) and malondialdehyde (MDA), protein levels of brain-derived neurotrophic factor (BDNF), tyrosine hydroxylase (TH), dopamine transporter (DAT), and catechol-O-methyltransferase (COMT), as well as activity of monoamine oxidase (MAO) in chronically stressed rats. The investigated parameters were quantified by real-time RT-PCR, Western blot analyses, and assays of enzyme activities. We found that lithium did not change gene expression of SOD1, CAT, GPx, and GR but decreased gene expression of SOD2 in chronically stressed rats. A very important result in this study was that lithium treatment decreased the enzyme activities of SOD1 and SOD2 but increased the enzyme activities of GPx and GR in stress condition, which indicates the control of redox balance. The reduced concentration of MDA confirms this. In addition, we found that lithium treatment decreased high protein levels of BDNF and DAT in chronically stressed rats to the level found in unstressed animals. Also, lithium treatment increased the expression of TH but decreased the enzyme activity of MAO B, which contributed to the increase of hippocampal concentration of DA in chronically stressed rats to the level of unstressed animals. Finally, lithium treatment in animals exposed to chronic stress increased the time spent in open arms. Lithium-induced modulation of hippocampal antioxidant status and attenuation of oxidative stress stabilized behavior in animals with high anxiety index. In addition, reduced oxidative stress was followed by the changes of both turnover of DA and levels of BDNF protein in chronically stressed rats treated with lithium. These findings may be important in preclinical research of the effects of lithium on oxidative stress level in pathological conditions.
T2  - Oxidative Medicine and Cellular Longevity
T1  - Modulation of Hippocampal Antioxidant Defense System in Chronically Stressed Rats by Lithium
VL  - 2019
SP  - 1
EP  - 11
DO  - 10.1155/2019/8745376
ER  - 

@article{
author = "Popović, Nataša M. and Stojiljković, Vesna and Pejić, Snežana and Todorović, Ana and Pavlović, Ivan and Gavrilović, Ljubica and Pajović, Snežana B.",
year = "2019",
abstract = "This study examined the effects of lithium on gene expression and activity of the antioxidant enzymes copper zinc superoxide dismutase (SOD1), manganese superoxide dismutase (SOD2), catalase (CAT), glutathione peroxidase (GPx), and glutathione reductase (GR) in the hippocampus of chronically stressed rats. In addition, we examined the effects of lithium on anxiety behaviors, hippocampal concentrations of dopamine (DA) and malondialdehyde (MDA), protein levels of brain-derived neurotrophic factor (BDNF), tyrosine hydroxylase (TH), dopamine transporter (DAT), and catechol-O-methyltransferase (COMT), as well as activity of monoamine oxidase (MAO) in chronically stressed rats. The investigated parameters were quantified by real-time RT-PCR, Western blot analyses, and assays of enzyme activities. We found that lithium did not change gene expression of SOD1, CAT, GPx, and GR but decreased gene expression of SOD2 in chronically stressed rats. A very important result in this study was that lithium treatment decreased the enzyme activities of SOD1 and SOD2 but increased the enzyme activities of GPx and GR in stress condition, which indicates the control of redox balance. The reduced concentration of MDA confirms this. In addition, we found that lithium treatment decreased high protein levels of BDNF and DAT in chronically stressed rats to the level found in unstressed animals. Also, lithium treatment increased the expression of TH but decreased the enzyme activity of MAO B, which contributed to the increase of hippocampal concentration of DA in chronically stressed rats to the level of unstressed animals. Finally, lithium treatment in animals exposed to chronic stress increased the time spent in open arms. Lithium-induced modulation of hippocampal antioxidant status and attenuation of oxidative stress stabilized behavior in animals with high anxiety index. In addition, reduced oxidative stress was followed by the changes of both turnover of DA and levels of BDNF protein in chronically stressed rats treated with lithium. These findings may be important in preclinical research of the effects of lithium on oxidative stress level in pathological conditions.",
journal = "Oxidative Medicine and Cellular Longevity",
title = "Modulation of Hippocampal Antioxidant Defense System in Chronically Stressed Rats by Lithium",
volume = "2019",
pages = "1-11",
doi = "10.1155/2019/8745376"
}

Popović, N. M., Stojiljković, V., Pejić, S., Todorović, A., Pavlović, I., Gavrilović, L.,& Pajović, S. B.. (2019). Modulation of Hippocampal Antioxidant Defense System in Chronically Stressed Rats by Lithium. in Oxidative Medicine and Cellular Longevity, 2019, 1-11.
https://doi.org/10.1155/2019/8745376

Popović NM, Stojiljković V, Pejić S, Todorović A, Pavlović I, Gavrilović L, Pajović SB. Modulation of Hippocampal Antioxidant Defense System in Chronically Stressed Rats by Lithium. in Oxidative Medicine and Cellular Longevity. 2019;2019:1-11.
doi:10.1155/2019/8745376 .

Popović, Nataša M., Stojiljković, Vesna, Pejić, Snežana, Todorović, Ana, Pavlović, Ivan, Gavrilović, Ljubica, Pajović, Snežana B., "Modulation of Hippocampal Antioxidant Defense System in Chronically Stressed Rats by Lithium" in Oxidative Medicine and Cellular Longevity, 2019 (2019):1-11,
https://doi.org/10.1155/2019/8745376 . .

TY  - JOUR
AU  - Todorović, Ana
AU  - Pejić, Snežana
AU  - Gavrilović, Ljubica
AU  - Pavlović, Ivan
AU  - Stojiljković, Vesna
AU  - Popović, Nataša M.
AU  - Pajović, Snežana B.
PY  - 2019
UR  - https://www.mdpi.com/2076-3921/8/4/97
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/8403
AB  - We previously found that compared to patients with benign uterine diseases (polyps, myomas), patients with premalignant (hyperplasia simplex and complex) and malignant (adenocarcinoma) lesions had enhanced lipid peroxidation and altered uterine antioxidant enzyme (AOE) activities. To further elucidate the mechanism of the observed changes, we examined protein and mRNA levels of copper-zinc superoxide dismutase (CuZnSOD), catalase (CAT), glutathione peroxidase (GPx), glutathione reductase (GR), and transcription factor Nrf2. We also examined correlations of AOE expression with AOE activity, lipid hydroperoxides (LOOH) level, and level of Nrf2. Our results showed decreased CuZnSOD, CAT, and Nrf2 levels, and increased GPx and GR levels in hyperplasias, while in patients with adenocarcinoma, the level of CAT was decreased and GR was increased, compared to benign groups. Similar changes in mRNA levels were also detected, indicating predominantly translational control of the AOE expression. The positive correlation of enzyme expression/activity was recorded for CuZnSOD, GPx, and GR, but only among groups with benign diseases. Only GR and GPx expressions were positively correlated with LOOH. Nrf2 protein was positively correlated with mRNA levels of CuZnSOD and GR. Observed results indicate involvement of diverse redox mechanisms in etiopathogenesis of different gynecological diseases, and may improve redox-based approaches in current clinical practice.
T2  - Antioxidants
T1  - Expression of Antioxidant Enzymes in Patients with Uterine Polyp, Myoma, Hyperplasia, and Adenocarcinoma
VL  - 8
IS  - 4
SP  - 97
DO  - 10.3390/antiox8040097
ER  - 

@article{
author = "Todorović, Ana and Pejić, Snežana and Gavrilović, Ljubica and Pavlović, Ivan and Stojiljković, Vesna and Popović, Nataša M. and Pajović, Snežana B.",
year = "2019",
abstract = "We previously found that compared to patients with benign uterine diseases (polyps, myomas), patients with premalignant (hyperplasia simplex and complex) and malignant (adenocarcinoma) lesions had enhanced lipid peroxidation and altered uterine antioxidant enzyme (AOE) activities. To further elucidate the mechanism of the observed changes, we examined protein and mRNA levels of copper-zinc superoxide dismutase (CuZnSOD), catalase (CAT), glutathione peroxidase (GPx), glutathione reductase (GR), and transcription factor Nrf2. We also examined correlations of AOE expression with AOE activity, lipid hydroperoxides (LOOH) level, and level of Nrf2. Our results showed decreased CuZnSOD, CAT, and Nrf2 levels, and increased GPx and GR levels in hyperplasias, while in patients with adenocarcinoma, the level of CAT was decreased and GR was increased, compared to benign groups. Similar changes in mRNA levels were also detected, indicating predominantly translational control of the AOE expression. The positive correlation of enzyme expression/activity was recorded for CuZnSOD, GPx, and GR, but only among groups with benign diseases. Only GR and GPx expressions were positively correlated with LOOH. Nrf2 protein was positively correlated with mRNA levels of CuZnSOD and GR. Observed results indicate involvement of diverse redox mechanisms in etiopathogenesis of different gynecological diseases, and may improve redox-based approaches in current clinical practice.",
journal = "Antioxidants",
title = "Expression of Antioxidant Enzymes in Patients with Uterine Polyp, Myoma, Hyperplasia, and Adenocarcinoma",
volume = "8",
number = "4",
pages = "97",
doi = "10.3390/antiox8040097"
}

Todorović, A., Pejić, S., Gavrilović, L., Pavlović, I., Stojiljković, V., Popović, N. M.,& Pajović, S. B.. (2019). Expression of Antioxidant Enzymes in Patients with Uterine Polyp, Myoma, Hyperplasia, and Adenocarcinoma. in Antioxidants, 8(4), 97.
https://doi.org/10.3390/antiox8040097

Todorović A, Pejić S, Gavrilović L, Pavlović I, Stojiljković V, Popović NM, Pajović SB. Expression of Antioxidant Enzymes in Patients with Uterine Polyp, Myoma, Hyperplasia, and Adenocarcinoma. in Antioxidants. 2019;8(4):97.
doi:10.3390/antiox8040097 .

Todorović, Ana, Pejić, Snežana, Gavrilović, Ljubica, Pavlović, Ivan, Stojiljković, Vesna, Popović, Nataša M., Pajović, Snežana B., "Expression of Antioxidant Enzymes in Patients with Uterine Polyp, Myoma, Hyperplasia, and Adenocarcinoma" in Antioxidants, 8, no. 4 (2019):97,
https://doi.org/10.3390/antiox8040097 . .

TY  - JOUR
AU  - Radojević-Škodrić, Sanja
AU  - Brašanac, Dimitrije
AU  - Đuričić, Slaviša M.
AU  - Glumac, Sofija
AU  - Lončar, Zlatibor
AU  - Pavlović, Ivan
AU  - Todorović, Ana
AU  - Nikolić, Gorana V.
AU  - Baralić, Ivana
AU  - Pejić, Snežana
PY  - 2019
UR  - https://peerj.com/articles/6212
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/8025
AB  - Background: Cyclin A overexpression is found in a variety of human tumors and correlates with unfavorable outcome. We analyzed immunohistochemical expression of cyclin A in Wilms tumor (WT) in relation to clinicopathological characteristics, preoperative chemotherapy (PrOpChTh), and overall survival (OS). Methods: This retrospective study involved 43 patients who underwent nephrectomy from January 1996 to October 2010. Tumor stage and histological subtype were determined by revised Societé International d’Oncologie Pediatrique protocol, based on histological components/alterations caused by PrOpChTh, within the prognostic group of low, intermediate and high risk, and with criteria for anaplasia. The regressive/necrotic changes in total tumor mass of primary tumor and the proportion of epithelial, blastemal, and stromal components in the remaining viable tumor tissue were also determined. Cyclin A expression was evaluated by immunohistochemistry using a polyclonal rabbit, antihuman antibody (H-432). Results: Cyclin A overexpression was found in 34.3% of WTs, with higher frequency in tumors with epithelial (31.3%) and blastemal (37.1%) components than those with stromal component (17.7%). Regarding histological type, cyclin A overexpression was found most often in focal anaplasia (100%), stromal (60%), and diffuse anaplastic (66.7) WTs. The overexpression was also more frequent in stages 3 and 4 (77.8% and 66.7%, respectively) compared to tumors in stages 1 and 2 (13.3% and 12.5%, respectively; p = 0.004) in all components, as well as in blastemal component in stages 3 and 4 (77.8% and 66.7%, respectively) vs. stages 1 and 2 (13.3% and 25%, respectively, p = 0.009). Cyclin A overexpression in all components was 66.7% in WTs with metastasis and 31.3% in WTs without metastasis (p = 0.265, Fisher test). Log-rank testing revealed differences of OS regarding stage (p = 0.000), prognostic groups (p = 0.001), and cyclin A expression in blastemal component (p = 0.025). After univariate analysis, tumor stage (p = 0.001), prognostic group (p = 0.004), and cyclin A expression in blastemal component (p = 0.042) were significant prognostic factors for OS; however, after multivariate analysis, none of these factors were confirmed as independent predictors of survival. Discussion: This study showed that cyclin A overexpression might be associated with the development and progression of WT with anaplasia. Also, cyclin A overexpression was more often observed in advanced stages (3 and 4) of WT, in the group of high-risk WTs, and in focal and diffuse anaplasia WTs. There was no relation of cyclin A overexpression and metastatic ability of WT. Although this study has not confirmed the prognostic value of cyclin A overexpression, its association with unfavorable prognosis should be further evaluated. Copyright 2019 Radojevic-Škodric et al.
T2  - PeerJ
T1  - Immunohistochemical analysis of cyclin A expression in Wilms tumor
VL  - 6
IS  - 1
SP  - e6212
DO  - 10.7717/peerj.6212
ER  - 

@article{
author = "Radojević-Škodrić, Sanja and Brašanac, Dimitrije and Đuričić, Slaviša M. and Glumac, Sofija and Lončar, Zlatibor and Pavlović, Ivan and Todorović, Ana and Nikolić, Gorana V. and Baralić, Ivana and Pejić, Snežana",
year = "2019",
abstract = "Background: Cyclin A overexpression is found in a variety of human tumors and correlates with unfavorable outcome. We analyzed immunohistochemical expression of cyclin A in Wilms tumor (WT) in relation to clinicopathological characteristics, preoperative chemotherapy (PrOpChTh), and overall survival (OS). Methods: This retrospective study involved 43 patients who underwent nephrectomy from January 1996 to October 2010. Tumor stage and histological subtype were determined by revised Societé International d’Oncologie Pediatrique protocol, based on histological components/alterations caused by PrOpChTh, within the prognostic group of low, intermediate and high risk, and with criteria for anaplasia. The regressive/necrotic changes in total tumor mass of primary tumor and the proportion of epithelial, blastemal, and stromal components in the remaining viable tumor tissue were also determined. Cyclin A expression was evaluated by immunohistochemistry using a polyclonal rabbit, antihuman antibody (H-432). Results: Cyclin A overexpression was found in 34.3% of WTs, with higher frequency in tumors with epithelial (31.3%) and blastemal (37.1%) components than those with stromal component (17.7%). Regarding histological type, cyclin A overexpression was found most often in focal anaplasia (100%), stromal (60%), and diffuse anaplastic (66.7) WTs. The overexpression was also more frequent in stages 3 and 4 (77.8% and 66.7%, respectively) compared to tumors in stages 1 and 2 (13.3% and 12.5%, respectively; p = 0.004) in all components, as well as in blastemal component in stages 3 and 4 (77.8% and 66.7%, respectively) vs. stages 1 and 2 (13.3% and 25%, respectively, p = 0.009). Cyclin A overexpression in all components was 66.7% in WTs with metastasis and 31.3% in WTs without metastasis (p = 0.265, Fisher test). Log-rank testing revealed differences of OS regarding stage (p = 0.000), prognostic groups (p = 0.001), and cyclin A expression in blastemal component (p = 0.025). After univariate analysis, tumor stage (p = 0.001), prognostic group (p = 0.004), and cyclin A expression in blastemal component (p = 0.042) were significant prognostic factors for OS; however, after multivariate analysis, none of these factors were confirmed as independent predictors of survival. Discussion: This study showed that cyclin A overexpression might be associated with the development and progression of WT with anaplasia. Also, cyclin A overexpression was more often observed in advanced stages (3 and 4) of WT, in the group of high-risk WTs, and in focal and diffuse anaplasia WTs. There was no relation of cyclin A overexpression and metastatic ability of WT. Although this study has not confirmed the prognostic value of cyclin A overexpression, its association with unfavorable prognosis should be further evaluated. Copyright 2019 Radojevic-Škodric et al.",
journal = "PeerJ",
title = "Immunohistochemical analysis of cyclin A expression in Wilms tumor",
volume = "6",
number = "1",
pages = "e6212",
doi = "10.7717/peerj.6212"
}

Radojević-Škodrić, S., Brašanac, D., Đuričić, S. M., Glumac, S., Lončar, Z., Pavlović, I., Todorović, A., Nikolić, G. V., Baralić, I.,& Pejić, S.. (2019). Immunohistochemical analysis of cyclin A expression in Wilms tumor. in PeerJ, 6(1), e6212.
https://doi.org/10.7717/peerj.6212

Radojević-Škodrić S, Brašanac D, Đuričić SM, Glumac S, Lončar Z, Pavlović I, Todorović A, Nikolić GV, Baralić I, Pejić S. Immunohistochemical analysis of cyclin A expression in Wilms tumor. in PeerJ. 2019;6(1):e6212.
doi:10.7717/peerj.6212 .

Radojević-Škodrić, Sanja, Brašanac, Dimitrije, Đuričić, Slaviša M., Glumac, Sofija, Lončar, Zlatibor, Pavlović, Ivan, Todorović, Ana, Nikolić, Gorana V., Baralić, Ivana, Pejić, Snežana, "Immunohistochemical analysis of cyclin A expression in Wilms tumor" in PeerJ, 6, no. 1 (2019):e6212,
https://doi.org/10.7717/peerj.6212 . .

TY  - JOUR
AU  - Latić, Dragana
AU  - Pejić, Snežana
AU  - Savić, Slaviša
AU  - Lončar, Zlatibor
AU  - Nikolić, Ivan M.
AU  - Nikolić, Gorana V.
AU  - Pavlović, Ivan
AU  - Radojević-Škodrić, Sanja
PY  - 2019
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/8078
AB  - Purpose: There is a need for identifying molecular prognostic biomarkers to better predict clinical outcomes in patients with renal cell carcinoma (RCC). This study investigated the pattern of cyclin D1 and p57 expression in RCC patients and evaluated their relation with clinicopathological characteristics and overall survival (OS). Methods: Immunohistochemistry was applied to paraffin-embedded tissue sections of 74 RCC patients. Two cut-off groups were defined by the fraction of positive cells as fol-lows: ≤10% and >10% positive cells for cyclin D1, and ≤5% and >5% positive cells for p57. Results: Cyclin D1 expression in >10% of positive cells was observed mostly in the clear cell RCC, while p57 expression in ≤5% of positive cells was found in 86% of chromophobe RCC specimens. The higher expression of cyclin D1 and lower expression of p57 were more frequent in grade I-II tumors. OS was associated with unfavorable clinicopathological characteristics. However, cyclin D1/p57 expression did not influence the survival rates. Conclusion: Although cyclin D1 and p57 expression did not affect survival rates in RCC patients, proper validation and establishment of the qualitative cut-off point are needed for these tumors.
T2  - Journal of BUON
T1  - Cyclin d1 and p57 expression in relation to clinicopathological characteristics and overall survival in patients with renal cell carcinoma
VL  - 24
IS  - 1
SP  - 301
EP  - 309
UR  - https://hdl.handle.net/21.15107/rcub_vinar_8078
ER  - 

@article{
author = "Latić, Dragana and Pejić, Snežana and Savić, Slaviša and Lončar, Zlatibor and Nikolić, Ivan M. and Nikolić, Gorana V. and Pavlović, Ivan and Radojević-Škodrić, Sanja",
year = "2019",
abstract = "Purpose: There is a need for identifying molecular prognostic biomarkers to better predict clinical outcomes in patients with renal cell carcinoma (RCC). This study investigated the pattern of cyclin D1 and p57 expression in RCC patients and evaluated their relation with clinicopathological characteristics and overall survival (OS). Methods: Immunohistochemistry was applied to paraffin-embedded tissue sections of 74 RCC patients. Two cut-off groups were defined by the fraction of positive cells as fol-lows: ≤10% and >10% positive cells for cyclin D1, and ≤5% and >5% positive cells for p57. Results: Cyclin D1 expression in >10% of positive cells was observed mostly in the clear cell RCC, while p57 expression in ≤5% of positive cells was found in 86% of chromophobe RCC specimens. The higher expression of cyclin D1 and lower expression of p57 were more frequent in grade I-II tumors. OS was associated with unfavorable clinicopathological characteristics. However, cyclin D1/p57 expression did not influence the survival rates. Conclusion: Although cyclin D1 and p57 expression did not affect survival rates in RCC patients, proper validation and establishment of the qualitative cut-off point are needed for these tumors.",
journal = "Journal of BUON",
title = "Cyclin d1 and p57 expression in relation to clinicopathological characteristics and overall survival in patients with renal cell carcinoma",
volume = "24",
number = "1",
pages = "301-309",
url = "https://hdl.handle.net/21.15107/rcub_vinar_8078"
}

Latić, D., Pejić, S., Savić, S., Lončar, Z., Nikolić, I. M., Nikolić, G. V., Pavlović, I.,& Radojević-Škodrić, S.. (2019). Cyclin d1 and p57 expression in relation to clinicopathological characteristics and overall survival in patients with renal cell carcinoma. in Journal of BUON, 24(1), 301-309.
https://hdl.handle.net/21.15107/rcub_vinar_8078

Latić D, Pejić S, Savić S, Lončar Z, Nikolić IM, Nikolić GV, Pavlović I, Radojević-Škodrić S. Cyclin d1 and p57 expression in relation to clinicopathological characteristics and overall survival in patients with renal cell carcinoma. in Journal of BUON. 2019;24(1):301-309.
https://hdl.handle.net/21.15107/rcub_vinar_8078 .

Latić, Dragana, Pejić, Snežana, Savić, Slaviša, Lončar, Zlatibor, Nikolić, Ivan M., Nikolić, Gorana V., Pavlović, Ivan, Radojević-Škodrić, Sanja, "Cyclin d1 and p57 expression in relation to clinicopathological characteristics and overall survival in patients with renal cell carcinoma" in Journal of BUON, 24, no. 1 (2019):301-309,
https://hdl.handle.net/21.15107/rcub_vinar_8078 .

TY  - JOUR
AU  - Miletić Vukajlović, Jadranka
AU  - Pejić, Snežana
AU  - Todorović, Ana
AU  - Valenta-Šobot, Ana
AU  - Drakulić, Dunja R.
AU  - Pavlović, Ivan
AU  - Stefanović, Aleksandra
AU  - Prostran, Milica
AU  - Ilić, Tihomir V.
AU  - Stojanov, Marina
PY  - 2019
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/8407
AB  - Backgroun / Aim. Constant production of free radicals and antioxidants (AO) in the cell is a part of normal cellular function. Their imbalance might take a part in pathophysiology of many diseases, including Parkinson’s disease (PD). Evaluation of the disease status, prooxidant-antioxidant balance (PAB) and antioxidants are being widely estimated. The aim of this study was to examine potential interaction between several AO variables (GSH, SOD, CAT and PAB) and clinicopathological features of patients with PD, particularly Hoehn and Yahr (H&Y) stage. Methods. A multivariate analysis of variance (MANOVA) was conducted to test the hypothesis of the mean differences between clinicopathological characteristics (gender, age at examination, duration of the disease, and H&Y stage) and AO variables, compared with age/sex matched healthy controls. The study included 91 patients with idiopatic PD patients and 20 healthy controls. Results. The multivariate effect size was estimated at 0.269, p <0.001, implying that 27.0% of the variance of the dependent variables was accounted for H&Y stage. Univariate tests showed that there were significant differences (p <0.001) across the H&Y stage on all AO variables. The H&Y stage remained significant predictor after controlling for the second variable, the disease duration (p <0.001, η2 = 0.249), and there were still significant differences across the H&Y stage on all variables, with effect size ( η2) ranging from 0.132, p =0.011 (lnGSH) to the still high values of 0.535 (lnPAB), 0.627 (lnSOD) and 0.964 (lnCAT). Conclusion. The results indicate that higher level of oxidative stress in blood of PD patients is possibly related to PD stage. Along with reduction of SOD and GSH level, CAT activity was elevated in comparison to healthy subjects. Furthermore, Pwas shifted toward oxidative stress.
T2  - Vojnosanitetski pregled
T1  - Antioxidant status and clinicopathological parameters in patients with Parkinson's disease
VL  - 77
IS  - 7
SP  - 724
EP  - 730
DO  - 10.2298/VSP180718148M
ER  - 

@article{
author = "Miletić Vukajlović, Jadranka and Pejić, Snežana and Todorović, Ana and Valenta-Šobot, Ana and Drakulić, Dunja R. and Pavlović, Ivan and Stefanović, Aleksandra and Prostran, Milica and Ilić, Tihomir V. and Stojanov, Marina",
year = "2019",
abstract = "Backgroun / Aim. Constant production of free radicals and antioxidants (AO) in the cell is a part of normal cellular function. Their imbalance might take a part in pathophysiology of many diseases, including Parkinson’s disease (PD). Evaluation of the disease status, prooxidant-antioxidant balance (PAB) and antioxidants are being widely estimated. The aim of this study was to examine potential interaction between several AO variables (GSH, SOD, CAT and PAB) and clinicopathological features of patients with PD, particularly Hoehn and Yahr (H&Y) stage. Methods. A multivariate analysis of variance (MANOVA) was conducted to test the hypothesis of the mean differences between clinicopathological characteristics (gender, age at examination, duration of the disease, and H&Y stage) and AO variables, compared with age/sex matched healthy controls. The study included 91 patients with idiopatic PD patients and 20 healthy controls. Results. The multivariate effect size was estimated at 0.269, p <0.001, implying that 27.0% of the variance of the dependent variables was accounted for H&Y stage. Univariate tests showed that there were significant differences (p <0.001) across the H&Y stage on all AO variables. The H&Y stage remained significant predictor after controlling for the second variable, the disease duration (p <0.001, η2 = 0.249), and there were still significant differences across the H&Y stage on all variables, with effect size ( η2) ranging from 0.132, p =0.011 (lnGSH) to the still high values of 0.535 (lnPAB), 0.627 (lnSOD) and 0.964 (lnCAT). Conclusion. The results indicate that higher level of oxidative stress in blood of PD patients is possibly related to PD stage. Along with reduction of SOD and GSH level, CAT activity was elevated in comparison to healthy subjects. Furthermore, Pwas shifted toward oxidative stress.",
journal = "Vojnosanitetski pregled",
title = "Antioxidant status and clinicopathological parameters in patients with Parkinson's disease",
volume = "77",
number = "7",
pages = "724-730",
doi = "10.2298/VSP180718148M"
}

Miletić Vukajlović, J., Pejić, S., Todorović, A., Valenta-Šobot, A., Drakulić, D. R., Pavlović, I., Stefanović, A., Prostran, M., Ilić, T. V.,& Stojanov, M.. (2019). Antioxidant status and clinicopathological parameters in patients with Parkinson's disease. in Vojnosanitetski pregled, 77(7), 724-730.
https://doi.org/10.2298/VSP180718148M

Miletić Vukajlović J, Pejić S, Todorović A, Valenta-Šobot A, Drakulić DR, Pavlović I, Stefanović A, Prostran M, Ilić TV, Stojanov M. Antioxidant status and clinicopathological parameters in patients with Parkinson's disease. in Vojnosanitetski pregled. 2019;77(7):724-730.
doi:10.2298/VSP180718148M .

Miletić Vukajlović, Jadranka, Pejić, Snežana, Todorović, Ana, Valenta-Šobot, Ana, Drakulić, Dunja R., Pavlović, Ivan, Stefanović, Aleksandra, Prostran, Milica, Ilić, Tihomir V., Stojanov, Marina, "Antioxidant status and clinicopathological parameters in patients with Parkinson's disease" in Vojnosanitetski pregled, 77, no. 7 (2019):724-730,
https://doi.org/10.2298/VSP180718148M . .

TY  - THES
AU  - Pavlović, Ivan
PY  - 2019
UR  - http://eteze.bg.ac.rs/application/showtheses?thesesId=7389
UR  - https://fedorabg.bg.ac.rs/fedora/get/o:21694/bdef:Content/download
UR  - https://plus.sr.cobiss.net/opac7/bib/1025244594
UR  - http://nardus.mpn.gov.rs/123456789/12271
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/8508
AB  - Тубуларни карцином бубрега (renal cell carcinoma, RCC) је најчешћи облик неоплазије бубрега. Ово је хетерогена болест која укључује хистолошке ентитете које одликују различита етиологија, клиничка манифестација, генетичка предиспозиција и исход. У последње две деценије је забележен константан раст инциденце RCC, посебно у развијеним земљама доброг социо-економског статуса. Инциденца RCC у Србији је релативно ниска у поређењу са већином европских земаља, али број оболелих константно расте, што је праћено и порастом морталитета. Због интензивне метаболичке активности и добре снабдевености кисеоником епителне ћелије бубрежних тубула су изложене деловању реактивних врста кисеоника (енг. reactive oxygen species, ROS). Физиолошки ниво ROS-a, у ћелијама бубрега, одржава антиоксидативни (AO) систем кога чине ензими (бакар цинк супероксид дисмутаза, CuZnSOD; манган супероксид дисмутаза, MnSOD; каталаза, CAT; глутатион пероксидаза, GPx; глутатион редуктазa, GR; глутатион трансферазa, GST) и неензимски молекул глутатион (GSH).Индикације о исходу RCC у земљама у развоју, укључујући Србију, су засноване на подацима о инциденци и морталитету, услед недостатка информација о преживљавању. И поред бројних студија, постоји потреба за дефинисањем поузданих прогностичких маркера код оболелих од RCC. Ова докторска дисертација је урађена са циљем да обезбеди податке о исходу болести код пацијената оболелих од RCC и идентификује факторе који утичу на укупно преживљавање испитаника. Полазећи од значајне улоге оксидативног стреса за процес канцерогенезе, у другом делу ове докторске дисертације је урађена анализа АО статуса која укључује одређивање параметара оксидативног стреса, липидне пероксидације и АО заштите. Такође, у овој студији је први пут процењен значај активности АО ензима, концентрације GSH и малондиалдехида (MDA) за преживљавање пацијената оболелих од RCC...
AB  - Renal cell carcinoma (RCC) is the most common type of kidney neoplasia. This is a heterogeneous disease that includes histological entities characterized with different etiology, clinical manifestation, genetic predisposition, and outcome. In the last two decades, there has been a constant increase of RCC incidence, particularly in developed countries of good socio-economic status. The incidence of RCC in Serbia is relatively low compared to the most European countries, but the number of patients constantly grows accompanied by an increase of mortality rates.Renal tubular epithelial cells are exposed to detrimental effect of reactive oxygen species (ROS) as result of good oxygen supply and intensive metabolic activity. Antioxidant (AO) system consisting of enzymes (copper-zinc superoxide dismutase, CuZnSOD; manganese superoxide dismutase, MnSOD; catalase, CAT; glutathione peroxidase, GPx; glutathione S-transferase, GST) and small non-enzymatic molecules such as glutathione (GSH), maintains physiological level of ROS in kidney cells.There is lack of data regarding survival for lower-income countries, including Serbia. Despite numerous studies, the reliable prognostic markers in patients with RCC are still necessary. This doctoral dissertation was conducted to provide the outcome data of Serbian patients with RCC in relation to clinicopathological features and to identify prognostic factors that could affect their overall survival (OS). Taking into account the significance of oxidative stress for the cancer development, in the second part of this doctoral dissertation, the AO status analysis was done, which includes assessment of oxidative stress, lipid peroxidation and AO protection. In this study, for the first time the effect of AO enzymes activity, GSH concentration and malondialdehyde (MDA) level on OS among patients with RCC was assessed.For survival study, we retrospectively collected clinicopathological data (age, sex, size, grade, stage and histological subtype of tumor) of patients diagnosed with RCC between 2009 and 2013. The follow-up period was five years, starting from the surgery date until death or the last follow-up appointment...
PB  - Универзитет у Београду, Биолошки факултет
T2  - Универзитет у Београду
T1  - Прогностички значај клиничко-патолошких и антиоксидативних параметара код пацијената оболелих од тубуларног карцинома бубрега
UR  - https://hdl.handle.net/21.15107/rcub_nardus_12271
ER  - 

@phdthesis{
author = "Pavlović, Ivan",
year = "2019",
abstract = "Тубуларни карцином бубрега (renal cell carcinoma, RCC) је најчешћи облик неоплазије бубрега. Ово је хетерогена болест која укључује хистолошке ентитете које одликују различита етиологија, клиничка манифестација, генетичка предиспозиција и исход. У последње две деценије је забележен константан раст инциденце RCC, посебно у развијеним земљама доброг социо-економског статуса. Инциденца RCC у Србији је релативно ниска у поређењу са већином европских земаља, али број оболелих константно расте, што је праћено и порастом морталитета. Због интензивне метаболичке активности и добре снабдевености кисеоником епителне ћелије бубрежних тубула су изложене деловању реактивних врста кисеоника (енг. reactive oxygen species, ROS). Физиолошки ниво ROS-a, у ћелијама бубрега, одржава антиоксидативни (AO) систем кога чине ензими (бакар цинк супероксид дисмутаза, CuZnSOD; манган супероксид дисмутаза, MnSOD; каталаза, CAT; глутатион пероксидаза, GPx; глутатион редуктазa, GR; глутатион трансферазa, GST) и неензимски молекул глутатион (GSH).Индикације о исходу RCC у земљама у развоју, укључујући Србију, су засноване на подацима о инциденци и морталитету, услед недостатка информација о преживљавању. И поред бројних студија, постоји потреба за дефинисањем поузданих прогностичких маркера код оболелих од RCC. Ова докторска дисертација је урађена са циљем да обезбеди податке о исходу болести код пацијената оболелих од RCC и идентификује факторе који утичу на укупно преживљавање испитаника. Полазећи од значајне улоге оксидативног стреса за процес канцерогенезе, у другом делу ове докторске дисертације је урађена анализа АО статуса која укључује одређивање параметара оксидативног стреса, липидне пероксидације и АО заштите. Такође, у овој студији је први пут процењен значај активности АО ензима, концентрације GSH и малондиалдехида (MDA) за преживљавање пацијената оболелих од RCC..., Renal cell carcinoma (RCC) is the most common type of kidney neoplasia. This is a heterogeneous disease that includes histological entities characterized with different etiology, clinical manifestation, genetic predisposition, and outcome. In the last two decades, there has been a constant increase of RCC incidence, particularly in developed countries of good socio-economic status. The incidence of RCC in Serbia is relatively low compared to the most European countries, but the number of patients constantly grows accompanied by an increase of mortality rates.Renal tubular epithelial cells are exposed to detrimental effect of reactive oxygen species (ROS) as result of good oxygen supply and intensive metabolic activity. Antioxidant (AO) system consisting of enzymes (copper-zinc superoxide dismutase, CuZnSOD; manganese superoxide dismutase, MnSOD; catalase, CAT; glutathione peroxidase, GPx; glutathione S-transferase, GST) and small non-enzymatic molecules such as glutathione (GSH), maintains physiological level of ROS in kidney cells.There is lack of data regarding survival for lower-income countries, including Serbia. Despite numerous studies, the reliable prognostic markers in patients with RCC are still necessary. This doctoral dissertation was conducted to provide the outcome data of Serbian patients with RCC in relation to clinicopathological features and to identify prognostic factors that could affect their overall survival (OS). Taking into account the significance of oxidative stress for the cancer development, in the second part of this doctoral dissertation, the AO status analysis was done, which includes assessment of oxidative stress, lipid peroxidation and AO protection. In this study, for the first time the effect of AO enzymes activity, GSH concentration and malondialdehyde (MDA) level on OS among patients with RCC was assessed.For survival study, we retrospectively collected clinicopathological data (age, sex, size, grade, stage and histological subtype of tumor) of patients diagnosed with RCC between 2009 and 2013. The follow-up period was five years, starting from the surgery date until death or the last follow-up appointment...",
publisher = "Универзитет у Београду, Биолошки факултет",
journal = "Универзитет у Београду",
title = "Прогностички значај клиничко-патолошких и антиоксидативних параметара код пацијената оболелих од тубуларног карцинома бубрега",
url = "https://hdl.handle.net/21.15107/rcub_nardus_12271"
}

Pavlović, I.. (2019). Прогностички значај клиничко-патолошких и антиоксидативних параметара код пацијената оболелих од тубуларног карцинома бубрега. in Универзитет у Београду
Универзитет у Београду, Биолошки факултет..
https://hdl.handle.net/21.15107/rcub_nardus_12271

Pavlović I. Прогностички значај клиничко-патолошких и антиоксидативних параметара код пацијената оболелих од тубуларног карцинома бубрега. in Универзитет у Београду. 2019;.
https://hdl.handle.net/21.15107/rcub_nardus_12271 .

Pavlović, Ivan, "Прогностички значај клиничко-патолошких и антиоксидативних параметара код пацијената оболелих од тубуларног карцинома бубрега" in Универзитет у Београду (2019),
https://hdl.handle.net/21.15107/rcub_nardus_12271 .

TY  - JOUR
AU  - Miller, Izak Patrik
AU  - Pavlović, Ivan
AU  - Poljšak, Borut
AU  - Šuput, Dušan
AU  - Milisav, Irina
PY  - 2019
UR  - https://www.mdpi.com/2076-3921/8/10/434
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/8402
AB  - High levels of reactive oxygen species (ROS) can lead to impairment of cell structure, biomolecules’ loss of function and cell death and are associated with liver diseases. Cells that survive increased ROS often undergo malignant transformation. Many cancer cells tolerate high levels of ROS. Here we report a transiently increased production of H2O2 and concomitant upregulation of antioxidative enzymes triggered by hepatocyte isolation; the H2O2 levels revert in about two days in culture. Three-day survival rate of the isolated cells in the presence of 2.5-fold increase of H2O2 is almost 80%. Apoptosis activation through the mitochondrial pathway is meanwhile reduced by inhibition of caspase-9 triggering. This reduction depends on the amount of H2O2 production, as decreased production of H2O2 in the presence of an antioxidant results in increased apoptosis triggering. These stress adaptations do not influence urea production, which is unchanged throughout the normal and stress adapted phases. We conclude that hepatocytes’ stress adaptation is mediated by increased ROS production. In this case, high ROS improve cell survival.
T2  - Antioxidants
T1  - Beneficial Role of ROS in Cell Survival: Moderate Increases in H2O2 Production Induced by Hepatocyte Isolation Mediate Stress Adaptation and Enhanced Survival
VL  - 8
IS  - 10
SP  - 434
DO  - 10.3390/antiox8100434
ER  - 

@article{
author = "Miller, Izak Patrik and Pavlović, Ivan and Poljšak, Borut and Šuput, Dušan and Milisav, Irina",
year = "2019",
abstract = "High levels of reactive oxygen species (ROS) can lead to impairment of cell structure, biomolecules’ loss of function and cell death and are associated with liver diseases. Cells that survive increased ROS often undergo malignant transformation. Many cancer cells tolerate high levels of ROS. Here we report a transiently increased production of H2O2 and concomitant upregulation of antioxidative enzymes triggered by hepatocyte isolation; the H2O2 levels revert in about two days in culture. Three-day survival rate of the isolated cells in the presence of 2.5-fold increase of H2O2 is almost 80%. Apoptosis activation through the mitochondrial pathway is meanwhile reduced by inhibition of caspase-9 triggering. This reduction depends on the amount of H2O2 production, as decreased production of H2O2 in the presence of an antioxidant results in increased apoptosis triggering. These stress adaptations do not influence urea production, which is unchanged throughout the normal and stress adapted phases. We conclude that hepatocytes’ stress adaptation is mediated by increased ROS production. In this case, high ROS improve cell survival.",
journal = "Antioxidants",
title = "Beneficial Role of ROS in Cell Survival: Moderate Increases in H2O2 Production Induced by Hepatocyte Isolation Mediate Stress Adaptation and Enhanced Survival",
volume = "8",
number = "10",
pages = "434",
doi = "10.3390/antiox8100434"
}

Miller, I. P., Pavlović, I., Poljšak, B., Šuput, D.,& Milisav, I.. (2019). Beneficial Role of ROS in Cell Survival: Moderate Increases in H2O2 Production Induced by Hepatocyte Isolation Mediate Stress Adaptation and Enhanced Survival. in Antioxidants, 8(10), 434.
https://doi.org/10.3390/antiox8100434

Miller IP, Pavlović I, Poljšak B, Šuput D, Milisav I. Beneficial Role of ROS in Cell Survival: Moderate Increases in H2O2 Production Induced by Hepatocyte Isolation Mediate Stress Adaptation and Enhanced Survival. in Antioxidants. 2019;8(10):434.
doi:10.3390/antiox8100434 .

Miller, Izak Patrik, Pavlović, Ivan, Poljšak, Borut, Šuput, Dušan, Milisav, Irina, "Beneficial Role of ROS in Cell Survival: Moderate Increases in H2O2 Production Induced by Hepatocyte Isolation Mediate Stress Adaptation and Enhanced Survival" in Antioxidants, 8, no. 10 (2019):434,
https://doi.org/10.3390/antiox8100434 . .

TY  - JOUR
AU  - Popović, Nataša M.
AU  - Pajović, Snežana B.
AU  - Stojiljković, Vesna
AU  - Todorović, Ana
AU  - Pejić, Snežana
AU  - Pavlović, Ivan
AU  - Gavrilović, Ljubica
PY  - 2018
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/8404
AB  - The effects of chronic restraint stress (CRS, 2 h during 14 days) on gene expression of tyrosine hydroxylase (TH), catechol-O-methyltransferase (COMT), and glutathione peroxidase (GPx) were studied in the rat hippocampus. Changes in the dopamine (DA) concentration and activities of monoamine oxidases (MAO A and MAO B) and GPx in this cerebral structure of chronically stressed rats were also examined. The investigated parameters were quantified using real-time RT-PCR, Western blot analyses, and assay of enzymatic activity. We found that CRS decreased the TH protein level and DA concentration, which probably confirms the statement that de novo synthesis of DA is suppressed under stress conditions. The increased activities of MAO B, as well as the increased level of COMT protein, are believed to be related to intensified DA catabolism conditions. Also, a decreased activity of GPx in the hippocampus of chronically stressed animals was found. The increased enzymatic activity of MAO B negatively correlated with the reduced activity of GPx under the above-mentioned stress conditions. These events in the hippocampus of chronically stressed animals could synergistically cause oxidative damage to the mitochondria. © 2019, Springer Science+Business Media, LLC, part of Springer Nature.
T2  - Neurophysiology
T1  - Activities of the Dopaminergic System and Glutathione Antioxidant System in the Hippocampus of Stressed rats
VL  - 50
IS  - 5
SP  - 332
EP  - 338
DO  - 10.1007/s11062-019-09758-z
ER  - 

@article{
author = "Popović, Nataša M. and Pajović, Snežana B. and Stojiljković, Vesna and Todorović, Ana and Pejić, Snežana and Pavlović, Ivan and Gavrilović, Ljubica",
year = "2018",
abstract = "The effects of chronic restraint stress (CRS, 2 h during 14 days) on gene expression of tyrosine hydroxylase (TH), catechol-O-methyltransferase (COMT), and glutathione peroxidase (GPx) were studied in the rat hippocampus. Changes in the dopamine (DA) concentration and activities of monoamine oxidases (MAO A and MAO B) and GPx in this cerebral structure of chronically stressed rats were also examined. The investigated parameters were quantified using real-time RT-PCR, Western blot analyses, and assay of enzymatic activity. We found that CRS decreased the TH protein level and DA concentration, which probably confirms the statement that de novo synthesis of DA is suppressed under stress conditions. The increased activities of MAO B, as well as the increased level of COMT protein, are believed to be related to intensified DA catabolism conditions. Also, a decreased activity of GPx in the hippocampus of chronically stressed animals was found. The increased enzymatic activity of MAO B negatively correlated with the reduced activity of GPx under the above-mentioned stress conditions. These events in the hippocampus of chronically stressed animals could synergistically cause oxidative damage to the mitochondria. © 2019, Springer Science+Business Media, LLC, part of Springer Nature.",
journal = "Neurophysiology",
title = "Activities of the Dopaminergic System and Glutathione Antioxidant System in the Hippocampus of Stressed rats",
volume = "50",
number = "5",
pages = "332-338",
doi = "10.1007/s11062-019-09758-z"
}

Popović, N. M., Pajović, S. B., Stojiljković, V., Todorović, A., Pejić, S., Pavlović, I.,& Gavrilović, L.. (2018). Activities of the Dopaminergic System and Glutathione Antioxidant System in the Hippocampus of Stressed rats. in Neurophysiology, 50(5), 332-338.
https://doi.org/10.1007/s11062-019-09758-z

Popović NM, Pajović SB, Stojiljković V, Todorović A, Pejić S, Pavlović I, Gavrilović L. Activities of the Dopaminergic System and Glutathione Antioxidant System in the Hippocampus of Stressed rats. in Neurophysiology. 2018;50(5):332-338.
doi:10.1007/s11062-019-09758-z .

Popović, Nataša M., Pajović, Snežana B., Stojiljković, Vesna, Todorović, Ana, Pejić, Snežana, Pavlović, Ivan, Gavrilović, Ljubica, "Activities of the Dopaminergic System and Glutathione Antioxidant System in the Hippocampus of Stressed rats" in Neurophysiology, 50, no. 5 (2018):332-338,
https://doi.org/10.1007/s11062-019-09758-z . .

TY  - CHAP
AU  - Gavrilović, Ljubica
AU  - Stojiljković, Vesna
AU  - Popović, Nataša M.
AU  - Pejić, Snežana
AU  - Todorović, Ana
AU  - Pavlović, Ivan
AU  - Pajović, Snežana B.
PY  - 2018
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/8406
AB  - We examined the effects of daily exercise on the gene expression of catecholamine biosynthetic enzymes (tyrosine hydroxylase (TH), dopamine-β-hydroxylase (DBH), and phenyl
ethanolamine N-methyltransferase (PNMT)), vesicular monoamine transporter 2 (VMAT 2),
antioxidant enzymes (superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx)), concentrations of catecholamines (noradrenaline (NA) and adrenaline (A))
and malondialdehyde (MDA), activities of monoamine oxidase (MAO), and antioxidant
enzymes in the spleen of chronically psychosocially stressed rats. Exposure of chronically
stressed rats to exercise increased the levels of PNMT protein by 19%, VMAT 2 mRNA by
100%, NA by 160%, and A by 140%; decreased/unchanged MAO enzyme activity; returned
concentrations of MDA to control level; and increased CAT and GPx mRNA levels (50%
and 150%, respectively). Exercise induced the accumulation of the catecholamines and a
decrease of stress-induced oxidative stress in the spleen, which may significantly affect the
immune-neuroendocrine interactions in stress conditions. Also, exercise induced the catecholaminergic system and antioxidant defense to become more ready to a novel stressor,
which indicates that exercise may induce potentially positive physiological adaptations.
Our combined model of chronic social isolation and long-term daily treadmill running in
rats may be a good animal model in the research of therapeutic role of exercise in human
disease caused by chronic stress.
PB  - IntechOpen
PB  - InTech
T2  - Experimental Animal Models of Human Diseases : An Effective Therapeutic Strategy, (ed.) Bartholomew Ibeh
T1  - Animal Models for Chronic Stress-Induced Oxidative Stress in the Spleen: The Role of Exercise and Catecholaminergic System
IS  - Ch. 14
SP  - 283
EP  - 310
DO  - 10.5772/intechopen.70008
ER  - 

@inbook{
editor = "Bartholomew, Ibeh",
author = "Gavrilović, Ljubica and Stojiljković, Vesna and Popović, Nataša M. and Pejić, Snežana and Todorović, Ana and Pavlović, Ivan and Pajović, Snežana B.",
year = "2018",
abstract = "We examined the effects of daily exercise on the gene expression of catecholamine biosynthetic enzymes (tyrosine hydroxylase (TH), dopamine-β-hydroxylase (DBH), and phenyl
ethanolamine N-methyltransferase (PNMT)), vesicular monoamine transporter 2 (VMAT 2),
antioxidant enzymes (superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx)), concentrations of catecholamines (noradrenaline (NA) and adrenaline (A))
and malondialdehyde (MDA), activities of monoamine oxidase (MAO), and antioxidant
enzymes in the spleen of chronically psychosocially stressed rats. Exposure of chronically
stressed rats to exercise increased the levels of PNMT protein by 19%, VMAT 2 mRNA by
100%, NA by 160%, and A by 140%; decreased/unchanged MAO enzyme activity; returned
concentrations of MDA to control level; and increased CAT and GPx mRNA levels (50%
and 150%, respectively). Exercise induced the accumulation of the catecholamines and a
decrease of stress-induced oxidative stress in the spleen, which may significantly affect the
immune-neuroendocrine interactions in stress conditions. Also, exercise induced the catecholaminergic system and antioxidant defense to become more ready to a novel stressor,
which indicates that exercise may induce potentially positive physiological adaptations.
Our combined model of chronic social isolation and long-term daily treadmill running in
rats may be a good animal model in the research of therapeutic role of exercise in human
disease caused by chronic stress.",
publisher = "IntechOpen, InTech",
journal = "Experimental Animal Models of Human Diseases : An Effective Therapeutic Strategy, (ed.) Bartholomew Ibeh",
booktitle = "Animal Models for Chronic Stress-Induced Oxidative Stress in the Spleen: The Role of Exercise and Catecholaminergic System",
number = "Ch. 14",
pages = "283-310",
doi = "10.5772/intechopen.70008"
}

Bartholomew, I., Gavrilović, L., Stojiljković, V., Popović, N. M., Pejić, S., Todorović, A., Pavlović, I.,& Pajović, S. B.. (2018). Animal Models for Chronic Stress-Induced Oxidative Stress in the Spleen: The Role of Exercise and Catecholaminergic System. in Experimental Animal Models of Human Diseases : An Effective Therapeutic Strategy, (ed.) Bartholomew Ibeh
IntechOpen.(Ch. 14), 283-310.
https://doi.org/10.5772/intechopen.70008

Bartholomew I, Gavrilović L, Stojiljković V, Popović NM, Pejić S, Todorović A, Pavlović I, Pajović SB. Animal Models for Chronic Stress-Induced Oxidative Stress in the Spleen: The Role of Exercise and Catecholaminergic System. in Experimental Animal Models of Human Diseases : An Effective Therapeutic Strategy, (ed.) Bartholomew Ibeh. 2018;(Ch. 14):283-310.
doi:10.5772/intechopen.70008 .

Bartholomew, Ibeh, Gavrilović, Ljubica, Stojiljković, Vesna, Popović, Nataša M., Pejić, Snežana, Todorović, Ana, Pavlović, Ivan, Pajović, Snežana B., "Animal Models for Chronic Stress-Induced Oxidative Stress in the Spleen: The Role of Exercise and Catecholaminergic System" in Experimental Animal Models of Human Diseases : An Effective Therapeutic Strategy, (ed.) Bartholomew Ibeh, no. Ch. 14 (2018):283-310,
https://doi.org/10.5772/intechopen.70008 . .

TY  - JOUR
AU  - Popović, Nataša M.
AU  - Pajović, Snežana B.
AU  - Stojiljković, Vesna
AU  - Pejić, Snežana
AU  - Todorović, Ana
AU  - Pavlović, Ivan
AU  - Gavrilović, Ljubica
PY  - 2017
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/1588
AB  - This study examined the effects of chronic restraint stress (CRS) on gene expression of tyrosine hydroxylase (TH), dopamine-beta-hydroxylase (DBH), dopamine transporter (DAT), noradrenaline transporter (NET), vesicular monoamine transporter 2 (VMAT2), catechol-O-methyltransferase (COMT) and antioxidant enzymes such as superoxide dismutase (SOD1 and SOD2), catalase (CAT), glutathione peroxidase (GPx) and glutathione reductase (GR), as well as concentrations of dopamine (DA) and noradrenaline (NA), activities of monoamine oxidase (MAO A and MAOB) and activities of antioxidant enzymes (SOD1, SOD2, CAT, GPx and GR) in the rat prefrontal cortex (PFC). We found that CRS decreases gene expression of TH and DBH and concentrations of DA, which probably confirms the decrease of de novo synthesis of catecholamine. CRS increased protein levels of NET and VMAT2, which was followed by increased NA concentration. The increased activity of MAO A and MAO B, as well as increased protein levels of COMT probably indicate increased catecholamine degradation, which was followed by increased activity of SOD1, SOD2 and CAT, as well as decreased activity of GPx under stress conditions. Our findings confirm the increased prefrontal noradrenergic turnover in animals exposed to CRS. The molecular mechanisms by which CRS changes catecholaminergic turnover and the antioxidant defense system in the PFC may be very important for research on numerous psychiatric diseases caused by chronic stress.
T2  - Folia Biologica (Krakow)
T1  - Prefrontal Catecholaminergic Turnover and Antioxidant Defense System of Chronically Stressed Rats
VL  - 65
IS  - 1
SP  - 43
EP  - 54
DO  - 10.3409/fb65_1.43
ER  - 

@article{
author = "Popović, Nataša M. and Pajović, Snežana B. and Stojiljković, Vesna and Pejić, Snežana and Todorović, Ana and Pavlović, Ivan and Gavrilović, Ljubica",
year = "2017",
abstract = "This study examined the effects of chronic restraint stress (CRS) on gene expression of tyrosine hydroxylase (TH), dopamine-beta-hydroxylase (DBH), dopamine transporter (DAT), noradrenaline transporter (NET), vesicular monoamine transporter 2 (VMAT2), catechol-O-methyltransferase (COMT) and antioxidant enzymes such as superoxide dismutase (SOD1 and SOD2), catalase (CAT), glutathione peroxidase (GPx) and glutathione reductase (GR), as well as concentrations of dopamine (DA) and noradrenaline (NA), activities of monoamine oxidase (MAO A and MAOB) and activities of antioxidant enzymes (SOD1, SOD2, CAT, GPx and GR) in the rat prefrontal cortex (PFC). We found that CRS decreases gene expression of TH and DBH and concentrations of DA, which probably confirms the decrease of de novo synthesis of catecholamine. CRS increased protein levels of NET and VMAT2, which was followed by increased NA concentration. The increased activity of MAO A and MAO B, as well as increased protein levels of COMT probably indicate increased catecholamine degradation, which was followed by increased activity of SOD1, SOD2 and CAT, as well as decreased activity of GPx under stress conditions. Our findings confirm the increased prefrontal noradrenergic turnover in animals exposed to CRS. The molecular mechanisms by which CRS changes catecholaminergic turnover and the antioxidant defense system in the PFC may be very important for research on numerous psychiatric diseases caused by chronic stress.",
journal = "Folia Biologica (Krakow)",
title = "Prefrontal Catecholaminergic Turnover and Antioxidant Defense System of Chronically Stressed Rats",
volume = "65",
number = "1",
pages = "43-54",
doi = "10.3409/fb65_1.43"
}

Popović, N. M., Pajović, S. B., Stojiljković, V., Pejić, S., Todorović, A., Pavlović, I.,& Gavrilović, L.. (2017). Prefrontal Catecholaminergic Turnover and Antioxidant Defense System of Chronically Stressed Rats. in Folia Biologica (Krakow), 65(1), 43-54.
https://doi.org/10.3409/fb65_1.43

Popović NM, Pajović SB, Stojiljković V, Pejić S, Todorović A, Pavlović I, Gavrilović L. Prefrontal Catecholaminergic Turnover and Antioxidant Defense System of Chronically Stressed Rats. in Folia Biologica (Krakow). 2017;65(1):43-54.
doi:10.3409/fb65_1.43 .

Popović, Nataša M., Pajović, Snežana B., Stojiljković, Vesna, Pejić, Snežana, Todorović, Ana, Pavlović, Ivan, Gavrilović, Ljubica, "Prefrontal Catecholaminergic Turnover and Antioxidant Defense System of Chronically Stressed Rats" in Folia Biologica (Krakow), 65, no. 1 (2017):43-54,
https://doi.org/10.3409/fb65_1.43 . .

TY  - JOUR
AU  - Pavlović, Ivan
AU  - Pejić, Snežana
AU  - Glumac, Sofija
AU  - Todorović, Ana
AU  - Stojiljković, Vesna
AU  - Popović, Nataša M.
AU  - Gavrilović, Ljubica
AU  - Pajović, Snežana B.
AU  - Radojević-Škodrić, Sanja
AU  - Džamić, Zoran
AU  - Basta-Jovanović, Gordana
PY  - 2017
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/1857
AB  - Purpose: Indications of kidney cancer outcome in lower-income countries are based on an incidence/mortality ratio due to lack of survival information. This study was conducted to provide outcome data in Serbian patients with renal cell carcinoma (RCC) and to identify prognostic factors that could affect their overall survival (OS). Methods: This retrospective study included 185 patients who underwent nephrectomy. We assessed certain clinicopathological data including age, gender, tumor size, grade, stage and histological subtypes for their possible impact on OS. Results: The 5-year OS was 63.2%. Significant association was found between OS and age (log-rank 12.455, p=0.006), tumor size (log-rank 26.425, p=0.000), grade (log-rank 13.249, p=0.000) and stage (log-rank 43.235, p=0.000). Univariate analysis indicated size (p=0.000), grade (p=0.001) and stage (p=0.000) as prognostic factors for OS. In multivariate analysis, grade (p=0.014) and stage (p=0.000) remained significant predictors of OS. Conclusion: Tumor grade and stage were identified as independent prognostic factors of OS survival in Serbian patients with RCC.
T2  - Journal of BUON
T1  - Clinicopathological characteristics and survival in Serbian patients with renal cell carcinoma: a retrospective analysis
VL  - 22
IS  - 6
SP  - 1434
EP  - 1440
UR  - https://hdl.handle.net/21.15107/rcub_vinar_1857
ER  - 

@article{
author = "Pavlović, Ivan and Pejić, Snežana and Glumac, Sofija and Todorović, Ana and Stojiljković, Vesna and Popović, Nataša M. and Gavrilović, Ljubica and Pajović, Snežana B. and Radojević-Škodrić, Sanja and Džamić, Zoran and Basta-Jovanović, Gordana",
year = "2017",
abstract = "Purpose: Indications of kidney cancer outcome in lower-income countries are based on an incidence/mortality ratio due to lack of survival information. This study was conducted to provide outcome data in Serbian patients with renal cell carcinoma (RCC) and to identify prognostic factors that could affect their overall survival (OS). Methods: This retrospective study included 185 patients who underwent nephrectomy. We assessed certain clinicopathological data including age, gender, tumor size, grade, stage and histological subtypes for their possible impact on OS. Results: The 5-year OS was 63.2%. Significant association was found between OS and age (log-rank 12.455, p=0.006), tumor size (log-rank 26.425, p=0.000), grade (log-rank 13.249, p=0.000) and stage (log-rank 43.235, p=0.000). Univariate analysis indicated size (p=0.000), grade (p=0.001) and stage (p=0.000) as prognostic factors for OS. In multivariate analysis, grade (p=0.014) and stage (p=0.000) remained significant predictors of OS. Conclusion: Tumor grade and stage were identified as independent prognostic factors of OS survival in Serbian patients with RCC.",
journal = "Journal of BUON",
title = "Clinicopathological characteristics and survival in Serbian patients with renal cell carcinoma: a retrospective analysis",
volume = "22",
number = "6",
pages = "1434-1440",
url = "https://hdl.handle.net/21.15107/rcub_vinar_1857"
}

Pavlović, I., Pejić, S., Glumac, S., Todorović, A., Stojiljković, V., Popović, N. M., Gavrilović, L., Pajović, S. B., Radojević-Škodrić, S., Džamić, Z.,& Basta-Jovanović, G.. (2017). Clinicopathological characteristics and survival in Serbian patients with renal cell carcinoma: a retrospective analysis. in Journal of BUON, 22(6), 1434-1440.
https://hdl.handle.net/21.15107/rcub_vinar_1857

Pavlović I, Pejić S, Glumac S, Todorović A, Stojiljković V, Popović NM, Gavrilović L, Pajović SB, Radojević-Škodrić S, Džamić Z, Basta-Jovanović G. Clinicopathological characteristics and survival in Serbian patients with renal cell carcinoma: a retrospective analysis. in Journal of BUON. 2017;22(6):1434-1440.
https://hdl.handle.net/21.15107/rcub_vinar_1857 .

Pavlović, Ivan, Pejić, Snežana, Glumac, Sofija, Todorović, Ana, Stojiljković, Vesna, Popović, Nataša M., Gavrilović, Ljubica, Pajović, Snežana B., Radojević-Škodrić, Sanja, Džamić, Zoran, Basta-Jovanović, Gordana, "Clinicopathological characteristics and survival in Serbian patients with renal cell carcinoma: a retrospective analysis" in Journal of BUON, 22, no. 6 (2017):1434-1440,
https://hdl.handle.net/21.15107/rcub_vinar_1857 .

TY  - JOUR
AU  - Popović, Nataša M.
AU  - Pajović, Snežana B.
AU  - Stojiljković, Vesna
AU  - Todorović, Ana
AU  - Pejić, Snežana
AU  - Pavlović, Ivan
AU  - Gavrilović, Ljubica
PY  - 2017
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/1908
AB  - This study examined the effects of chronic restraint stress (CRS: 2 hours x 14 days) on gene expression of three antioxidant enzymes, copper, zinc superoxide dismutase (SOD 1), manganese superoxide dismutase (SOD 2) and catalase (CAT) in the rat hippocampus. Also, we examined changes in the activities of SOD 1, SOD 2 and CAT in the hippocampus of chronically stressed rats. Investigated parameters were quantified by using real-time RT-PCR, Western blot analysis and assay of enzymatic activity. We found that CRS did not change mRNA and protein levels of SOD 1 and CAT, but increased mRNA and protein levels of SOD 2. However, CRS treatment increased the enzyme activities of SOD 1, SOD 2 and CAT. Our findings indicate that the increased activity of antioxidant enzymes (SOD 1, SOD 2 and CAT) in the hippocampus may be an important adaptive phenomenon of the antioxidant defense system in chronically stressed rats.
T2  - Acta Veterinaria, Beograd
T1  - Increased Activity of Hippocampal Antioxidant Enzymes as An Important Adaptive Phenomenon of the Antioxidant Defense System in Chronically Stressed Rats
VL  - 67
IS  - 4
SP  - 540
EP  - 550
DO  - 10.1515/acve-2017-0043
ER  - 

@article{
author = "Popović, Nataša M. and Pajović, Snežana B. and Stojiljković, Vesna and Todorović, Ana and Pejić, Snežana and Pavlović, Ivan and Gavrilović, Ljubica",
year = "2017",
abstract = "This study examined the effects of chronic restraint stress (CRS: 2 hours x 14 days) on gene expression of three antioxidant enzymes, copper, zinc superoxide dismutase (SOD 1), manganese superoxide dismutase (SOD 2) and catalase (CAT) in the rat hippocampus. Also, we examined changes in the activities of SOD 1, SOD 2 and CAT in the hippocampus of chronically stressed rats. Investigated parameters were quantified by using real-time RT-PCR, Western blot analysis and assay of enzymatic activity. We found that CRS did not change mRNA and protein levels of SOD 1 and CAT, but increased mRNA and protein levels of SOD 2. However, CRS treatment increased the enzyme activities of SOD 1, SOD 2 and CAT. Our findings indicate that the increased activity of antioxidant enzymes (SOD 1, SOD 2 and CAT) in the hippocampus may be an important adaptive phenomenon of the antioxidant defense system in chronically stressed rats.",
journal = "Acta Veterinaria, Beograd",
title = "Increased Activity of Hippocampal Antioxidant Enzymes as An Important Adaptive Phenomenon of the Antioxidant Defense System in Chronically Stressed Rats",
volume = "67",
number = "4",
pages = "540-550",
doi = "10.1515/acve-2017-0043"
}

Popović, N. M., Pajović, S. B., Stojiljković, V., Todorović, A., Pejić, S., Pavlović, I.,& Gavrilović, L.. (2017). Increased Activity of Hippocampal Antioxidant Enzymes as An Important Adaptive Phenomenon of the Antioxidant Defense System in Chronically Stressed Rats. in Acta Veterinaria, Beograd, 67(4), 540-550.
https://doi.org/10.1515/acve-2017-0043

Popović NM, Pajović SB, Stojiljković V, Todorović A, Pejić S, Pavlović I, Gavrilović L. Increased Activity of Hippocampal Antioxidant Enzymes as An Important Adaptive Phenomenon of the Antioxidant Defense System in Chronically Stressed Rats. in Acta Veterinaria, Beograd. 2017;67(4):540-550.
doi:10.1515/acve-2017-0043 .

Popović, Nataša M., Pajović, Snežana B., Stojiljković, Vesna, Todorović, Ana, Pejić, Snežana, Pavlović, Ivan, Gavrilović, Ljubica, "Increased Activity of Hippocampal Antioxidant Enzymes as An Important Adaptive Phenomenon of the Antioxidant Defense System in Chronically Stressed Rats" in Acta Veterinaria, Beograd, 67, no. 4 (2017):540-550,
https://doi.org/10.1515/acve-2017-0043 . .

TY  - CONF
AU  - Stojiljković, Vesna
AU  - Gavrilović, Ljubica
AU  - Pejić, Snežana
AU  - Todorović, Ana
AU  - Popović, Nataša M.
AU  - Pavlović, Ivan
AU  - Pajović, Snežana B.
PY  - 2017
UR  - http://www.rad-proceedings.org/paper.php?id=152
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/7995
AB  - Celiac disease (CD) is an autoimmune disorder provoked by the wheat gluten and related proteins from other grains. The only treatment for the patients is a lifelong gluten free diet (GFD). Oxidative stress has been implicated in the pathogenesis of CD. The aim of this study was to examine the modulation of the biochemical response to oxidative stress in children affected by CD. The study involved peripheral blood samples and small intestinal biopsies from 69 children diagnosed with CD. According to the histological findings, patients were divided into following groups: Marsh 0: normal mucosa with no signs of inflammation (n=31); Marsh 1: mucosa was characterized by intraepithelial lymphocytosis (n=5); Marsh 2: intraepithelial lymphocytosis was accompanied by crypt hyperplasia (n=4); Marsh 3a: mucosa showed partial villous atrophy (n=20); Marsh 3b: subtotal villous atrophy was present (n=9). For the statistical purposes groups Marsh 1 and Marsh 2 were treated as one (Marsh 1+2, n=9). The activities and protein levels of copper, zinc superoxide dismutase (CuZnSOD) and manganese SOD (MnSOD), as well as the concentrations of lipid hydroperoxides (LOOH) were determined in intestinal biopsies, while in the peripheral blood, MnSOD activity was not measured, due to the methodological obstacles. CuZnSOD activity in the blood varied significantly between the analyzed groups. Marsh 3a and Marsh 3b had increased CuZnSOD activity comparing to the Marsh 0 (P < 0.05). LOOH concentration also varied significantly. LOOH level was higher in the blood of Marsh 3a (P < 0.001) and Marsh 3b (P < 0.05), than in Marsh 0. In the biopsy samples, MnSOD activity and LOOH concentration showed significant differences between the groups, while no significant difference was found for CuZnSOD activity. In comparison to Marsh 0, MnSOD activity was significantly elevated in Marsh 3a (P < 0.01). Significant increase in LOOH concentration was found in Marsh 3a (P < 0.001) and Marsh 3b (P < 0.01), comparing to Marsh 0. In addition, Marsh 3a group had higher LOOH concentration than Marsh 1+2. Relative MnSOD and CuZnSOD protein level in the peripheral blood and intestinal mucosa did not vary significantly between the analyzed groups. Positive correlations were found between the severity of mucosal lesion and CuZnSOD activity (P < 0.001), as well as LOOH concentration (P < 0.001) in the peripheral blood. Similar correlations were found also in intestinal mucosa: MnSOD: P < 0.05; CuZnSOD: P < 0.05; LOOH: P < 0.001. Our results show that oxidant/antioxidant balance is disturbed in CD patients with mucosal lesions. An increase in SOD activity as a consequence of oxidant pressure is not enough to maintain the normal level of free radicals, which leads to enhanced lipid peroxidation. These processes persist even in some patients on a long-term GFD.
PB  - RAD Association
C3  - RAD Conference Proceedings
T1  - Superoxide dismutase and lipid peroxidation in children affected by celiac disease
VL  - 2
SP  - 237
EP  - 242
DO  - 10.21175/RadProc.2017.49
ER  - 

@conference{
author = "Stojiljković, Vesna and Gavrilović, Ljubica and Pejić, Snežana and Todorović, Ana and Popović, Nataša M. and Pavlović, Ivan and Pajović, Snežana B.",
year = "2017",
abstract = "Celiac disease (CD) is an autoimmune disorder provoked by the wheat gluten and related proteins from other grains. The only treatment for the patients is a lifelong gluten free diet (GFD). Oxidative stress has been implicated in the pathogenesis of CD. The aim of this study was to examine the modulation of the biochemical response to oxidative stress in children affected by CD. The study involved peripheral blood samples and small intestinal biopsies from 69 children diagnosed with CD. According to the histological findings, patients were divided into following groups: Marsh 0: normal mucosa with no signs of inflammation (n=31); Marsh 1: mucosa was characterized by intraepithelial lymphocytosis (n=5); Marsh 2: intraepithelial lymphocytosis was accompanied by crypt hyperplasia (n=4); Marsh 3a: mucosa showed partial villous atrophy (n=20); Marsh 3b: subtotal villous atrophy was present (n=9). For the statistical purposes groups Marsh 1 and Marsh 2 were treated as one (Marsh 1+2, n=9). The activities and protein levels of copper, zinc superoxide dismutase (CuZnSOD) and manganese SOD (MnSOD), as well as the concentrations of lipid hydroperoxides (LOOH) were determined in intestinal biopsies, while in the peripheral blood, MnSOD activity was not measured, due to the methodological obstacles. CuZnSOD activity in the blood varied significantly between the analyzed groups. Marsh 3a and Marsh 3b had increased CuZnSOD activity comparing to the Marsh 0 (P < 0.05). LOOH concentration also varied significantly. LOOH level was higher in the blood of Marsh 3a (P < 0.001) and Marsh 3b (P < 0.05), than in Marsh 0. In the biopsy samples, MnSOD activity and LOOH concentration showed significant differences between the groups, while no significant difference was found for CuZnSOD activity. In comparison to Marsh 0, MnSOD activity was significantly elevated in Marsh 3a (P < 0.01). Significant increase in LOOH concentration was found in Marsh 3a (P < 0.001) and Marsh 3b (P < 0.01), comparing to Marsh 0. In addition, Marsh 3a group had higher LOOH concentration than Marsh 1+2. Relative MnSOD and CuZnSOD protein level in the peripheral blood and intestinal mucosa did not vary significantly between the analyzed groups. Positive correlations were found between the severity of mucosal lesion and CuZnSOD activity (P < 0.001), as well as LOOH concentration (P < 0.001) in the peripheral blood. Similar correlations were found also in intestinal mucosa: MnSOD: P < 0.05; CuZnSOD: P < 0.05; LOOH: P < 0.001. Our results show that oxidant/antioxidant balance is disturbed in CD patients with mucosal lesions. An increase in SOD activity as a consequence of oxidant pressure is not enough to maintain the normal level of free radicals, which leads to enhanced lipid peroxidation. These processes persist even in some patients on a long-term GFD.",
publisher = "RAD Association",
journal = "RAD Conference Proceedings",
title = "Superoxide dismutase and lipid peroxidation in children affected by celiac disease",
volume = "2",
pages = "237-242",
doi = "10.21175/RadProc.2017.49"
}

Stojiljković, V., Gavrilović, L., Pejić, S., Todorović, A., Popović, N. M., Pavlović, I.,& Pajović, S. B.. (2017). Superoxide dismutase and lipid peroxidation in children affected by celiac disease. in RAD Conference Proceedings
RAD Association., 2, 237-242.
https://doi.org/10.21175/RadProc.2017.49

Stojiljković V, Gavrilović L, Pejić S, Todorović A, Popović NM, Pavlović I, Pajović SB. Superoxide dismutase and lipid peroxidation in children affected by celiac disease. in RAD Conference Proceedings. 2017;2:237-242.
doi:10.21175/RadProc.2017.49 .

Stojiljković, Vesna, Gavrilović, Ljubica, Pejić, Snežana, Todorović, Ana, Popović, Nataša M., Pavlović, Ivan, Pajović, Snežana B., "Superoxide dismutase and lipid peroxidation in children affected by celiac disease" in RAD Conference Proceedings, 2 (2017):237-242,
https://doi.org/10.21175/RadProc.2017.49 . .

TY  - CONF
AU  - Popović, Nataša M.
AU  - Pajović, Snežana B.
AU  - Stojiljković, Vesna
AU  - Todorović, Ana
AU  - Pejić, Snežana
AU  - Pavlović, Ivan
AU  - Gavrilović, Ljubica
PY  - 2017
UR  - http://www.rad-proceedings.org/paper.php?id=155
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/7996
AB  - Chronic stress induces over-activation and dysfunction of stress-activated systems, resulting in further brain damage and depressive-like behavior. Depression is a potentially life-threatening disorder that affects people and, therefore, it is one of the most important public health problems. This study examined the effects of chronic restraint stress (CRS: 2 hours × 14 days) on the anxiety-like and depression-like behaviors in rats, as well as on the possible changes in the concentrations of dopamine (DA) and noradrenaline (NA) in the prefrontal cortex and hippocampus. We observed a decrease in the number of entries into open arms and time spent in open arms during the elevated plus-maze test (anxiety-like behavior), as well as the increased immobility during the forced swimming test (depression-like behavior). In addition, we found that CRS increases concentration of NA and decreases concentration of DA in the prefrontal cortex and hippocampus. Also, we recorded a significant correlation between the animal behavior and levels of neurotransmitters in the prefrontal cortex and hippocampus in stress conditions provoked by CRS. The results presented here suggest that there is a relationship between the animal behavior and levels of neurotransmitters in the prefrontal cortex and hippocampus in stress conditions provoked by CRS, which may be important in the research of numerous psychiatric diseases caused by chronic stress. © RAD Conference Proceedings. All rights reserved.
PB  - RAD Association
C3  - RAD Conference Proceedings
T1  - Relationship between behaviors and catecholamine content in prefrontal cortex and hippocampus of chronically stressed rats
VL  - 2
SP  - 255
EP  - 259
DO  - 10.21175/RadProc.2017.52
ER  - 

@conference{
author = "Popović, Nataša M. and Pajović, Snežana B. and Stojiljković, Vesna and Todorović, Ana and Pejić, Snežana and Pavlović, Ivan and Gavrilović, Ljubica",
year = "2017",
abstract = "Chronic stress induces over-activation and dysfunction of stress-activated systems, resulting in further brain damage and depressive-like behavior. Depression is a potentially life-threatening disorder that affects people and, therefore, it is one of the most important public health problems. This study examined the effects of chronic restraint stress (CRS: 2 hours × 14 days) on the anxiety-like and depression-like behaviors in rats, as well as on the possible changes in the concentrations of dopamine (DA) and noradrenaline (NA) in the prefrontal cortex and hippocampus. We observed a decrease in the number of entries into open arms and time spent in open arms during the elevated plus-maze test (anxiety-like behavior), as well as the increased immobility during the forced swimming test (depression-like behavior). In addition, we found that CRS increases concentration of NA and decreases concentration of DA in the prefrontal cortex and hippocampus. Also, we recorded a significant correlation between the animal behavior and levels of neurotransmitters in the prefrontal cortex and hippocampus in stress conditions provoked by CRS. The results presented here suggest that there is a relationship between the animal behavior and levels of neurotransmitters in the prefrontal cortex and hippocampus in stress conditions provoked by CRS, which may be important in the research of numerous psychiatric diseases caused by chronic stress. © RAD Conference Proceedings. All rights reserved.",
publisher = "RAD Association",
journal = "RAD Conference Proceedings",
title = "Relationship between behaviors and catecholamine content in prefrontal cortex and hippocampus of chronically stressed rats",
volume = "2",
pages = "255-259",
doi = "10.21175/RadProc.2017.52"
}

Popović, N. M., Pajović, S. B., Stojiljković, V., Todorović, A., Pejić, S., Pavlović, I.,& Gavrilović, L.. (2017). Relationship between behaviors and catecholamine content in prefrontal cortex and hippocampus of chronically stressed rats. in RAD Conference Proceedings
RAD Association., 2, 255-259.
https://doi.org/10.21175/RadProc.2017.52

Popović NM, Pajović SB, Stojiljković V, Todorović A, Pejić S, Pavlović I, Gavrilović L. Relationship between behaviors and catecholamine content in prefrontal cortex and hippocampus of chronically stressed rats. in RAD Conference Proceedings. 2017;2:255-259.
doi:10.21175/RadProc.2017.52 .

Popović, Nataša M., Pajović, Snežana B., Stojiljković, Vesna, Todorović, Ana, Pejić, Snežana, Pavlović, Ivan, Gavrilović, Ljubica, "Relationship between behaviors and catecholamine content in prefrontal cortex and hippocampus of chronically stressed rats" in RAD Conference Proceedings, 2 (2017):255-259,
https://doi.org/10.21175/RadProc.2017.52 . .

TY  - JOUR
AU  - Spasojević-Tišma, Vera D.
AU  - Matović, Milovan
AU  - Mihaljević, Olgica B.
AU  - Živančević-Simonović, Snežana T.
AU  - Jeremic, Marija Z.
AU  - Jakovljević, Vladimir Lj.
AU  - Todorović, Vera N.
AU  - Pavlović, Ivan
AU  - Pejić, Snežana
AU  - Todorović, Ana
PY  - 2017
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/1935
AB  - The radioactive iodine (I-131) ablation is a well-accepted treatment modality for differentiated thyroid cancer patients. Unfortunately, the radiation induces the oxidative stress and damages cells and tissues, simultaneously activating the mechanisms of antioxidative defense. Since the mechanisms of those processes are not completely known, we wanted to examine the changes in the most important reactive oxygen species and antioxidative components, as well as their correlation and significance for lipid peroxidation. Our results showed that the level of thiobarbituric acid reactive substances was increased during the first 30 days after the radiotherapy. Among antioxidant components, superoxide dismutase was increased in the 3rd and 30th day; catalase in 7th and reduced glutathione in 3rd and 7th day after the radiotherapy. As regards the prooxidants, the reduction of hydrogen peroxide (H2O2) was recorded in 7th and 30th day, and superoxide anion radical (O-2(center dot-)) was unchanged after the exposure to I-131. These results indicate that differentiated thyroid cancer patients are under constant oxidative stress despite the observed increase in antioxidative and reduction in prooxidative parameters. The understanding of these early processes is important since their progress determines the latter effects of I-131 therapy.
T2  - Nuclear technology and radiation protection
T1  - Redox Parameters in Blood of Thyroid Cancer Patients After the Radioiodine Ablation
VL  - 32
IS  - 4
SP  - 358
EP  - 365
DO  - 10.2298/NTRP1704358S
ER  - 

@article{
author = "Spasojević-Tišma, Vera D. and Matović, Milovan and Mihaljević, Olgica B. and Živančević-Simonović, Snežana T. and Jeremic, Marija Z. and Jakovljević, Vladimir Lj. and Todorović, Vera N. and Pavlović, Ivan and Pejić, Snežana and Todorović, Ana",
year = "2017",
abstract = "The radioactive iodine (I-131) ablation is a well-accepted treatment modality for differentiated thyroid cancer patients. Unfortunately, the radiation induces the oxidative stress and damages cells and tissues, simultaneously activating the mechanisms of antioxidative defense. Since the mechanisms of those processes are not completely known, we wanted to examine the changes in the most important reactive oxygen species and antioxidative components, as well as their correlation and significance for lipid peroxidation. Our results showed that the level of thiobarbituric acid reactive substances was increased during the first 30 days after the radiotherapy. Among antioxidant components, superoxide dismutase was increased in the 3rd and 30th day; catalase in 7th and reduced glutathione in 3rd and 7th day after the radiotherapy. As regards the prooxidants, the reduction of hydrogen peroxide (H2O2) was recorded in 7th and 30th day, and superoxide anion radical (O-2(center dot-)) was unchanged after the exposure to I-131. These results indicate that differentiated thyroid cancer patients are under constant oxidative stress despite the observed increase in antioxidative and reduction in prooxidative parameters. The understanding of these early processes is important since their progress determines the latter effects of I-131 therapy.",
journal = "Nuclear technology and radiation protection",
title = "Redox Parameters in Blood of Thyroid Cancer Patients After the Radioiodine Ablation",
volume = "32",
number = "4",
pages = "358-365",
doi = "10.2298/NTRP1704358S"
}

Spasojević-Tišma, V. D., Matović, M., Mihaljević, O. B., Živančević-Simonović, S. T., Jeremic, M. Z., Jakovljević, V. Lj., Todorović, V. N., Pavlović, I., Pejić, S.,& Todorović, A.. (2017). Redox Parameters in Blood of Thyroid Cancer Patients After the Radioiodine Ablation. in Nuclear technology and radiation protection, 32(4), 358-365.
https://doi.org/10.2298/NTRP1704358S

Spasojević-Tišma VD, Matović M, Mihaljević OB, Živančević-Simonović ST, Jeremic MZ, Jakovljević VL, Todorović VN, Pavlović I, Pejić S, Todorović A. Redox Parameters in Blood of Thyroid Cancer Patients After the Radioiodine Ablation. in Nuclear technology and radiation protection. 2017;32(4):358-365.
doi:10.2298/NTRP1704358S .

Spasojević-Tišma, Vera D., Matović, Milovan, Mihaljević, Olgica B., Živančević-Simonović, Snežana T., Jeremic, Marija Z., Jakovljević, Vladimir Lj., Todorović, Vera N., Pavlović, Ivan, Pejić, Snežana, Todorović, Ana, "Redox Parameters in Blood of Thyroid Cancer Patients After the Radioiodine Ablation" in Nuclear technology and radiation protection, 32, no. 4 (2017):358-365,
https://doi.org/10.2298/NTRP1704358S . .

TY  - JOUR
AU  - Pejić, Snežana
AU  - Stojiljković, Vesna
AU  - Todorović, Ana
AU  - Gavrilović, Ljubica
AU  - Pavlović, Ivan
AU  - Popović, Nataša M.
AU  - Pajović, Snežana B.
PY  - 2016
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/1301
AB  - The study deals with manganese superoxide dismutase, copper, zinc superoxide dismutase, and catalase activities in brain cortex of Wistar rats exposed to acute stress (immobilization or cold for 2 h), chronic stress (long-term isolation or long-term forced swimming for 21 days), or to combined chronic/acute stress. We observed that i) single episodes of acute stress by immobilization increased activity of both superoxide dismutases; ii) both types of chronic stresses significantly elevated activities of all examined enzymes; iii) chronic social isolation was a much stronger stressor than physical stress by swimming; iv) in animals pre-exposed to chronic isolation, additional stress by immobilization or cold significantly decreased previously elevated activities of all enzymes, while after chronic swimming, acute immobilization lowered only catalase activity. The obtained results indicate that stress conditions most probably altered the cell redox equilibrium, thus influencing the antioxidant response in brain cortex. Further investigation of neuronal prooxidant/antioxidant cellular conditions is needed to improve the prevention and treatment of various stress induced diseases.
T2  - Folia Biologica (Krakow)
T1  - Antioxidant Enzymes in Brain Cortex of Rats Exposed to Acute, Chronic and Combined Stress
VL  - 64
IS  - 3
SP  - 189
EP  - 195
DO  - 10.3409/fb64_3.189
ER  - 

@article{
author = "Pejić, Snežana and Stojiljković, Vesna and Todorović, Ana and Gavrilović, Ljubica and Pavlović, Ivan and Popović, Nataša M. and Pajović, Snežana B.",
year = "2016",
abstract = "The study deals with manganese superoxide dismutase, copper, zinc superoxide dismutase, and catalase activities in brain cortex of Wistar rats exposed to acute stress (immobilization or cold for 2 h), chronic stress (long-term isolation or long-term forced swimming for 21 days), or to combined chronic/acute stress. We observed that i) single episodes of acute stress by immobilization increased activity of both superoxide dismutases; ii) both types of chronic stresses significantly elevated activities of all examined enzymes; iii) chronic social isolation was a much stronger stressor than physical stress by swimming; iv) in animals pre-exposed to chronic isolation, additional stress by immobilization or cold significantly decreased previously elevated activities of all enzymes, while after chronic swimming, acute immobilization lowered only catalase activity. The obtained results indicate that stress conditions most probably altered the cell redox equilibrium, thus influencing the antioxidant response in brain cortex. Further investigation of neuronal prooxidant/antioxidant cellular conditions is needed to improve the prevention and treatment of various stress induced diseases.",
journal = "Folia Biologica (Krakow)",
title = "Antioxidant Enzymes in Brain Cortex of Rats Exposed to Acute, Chronic and Combined Stress",
volume = "64",
number = "3",
pages = "189-195",
doi = "10.3409/fb64_3.189"
}

Pejić, S., Stojiljković, V., Todorović, A., Gavrilović, L., Pavlović, I., Popović, N. M.,& Pajović, S. B.. (2016). Antioxidant Enzymes in Brain Cortex of Rats Exposed to Acute, Chronic and Combined Stress. in Folia Biologica (Krakow), 64(3), 189-195.
https://doi.org/10.3409/fb64_3.189

Pejić S, Stojiljković V, Todorović A, Gavrilović L, Pavlović I, Popović NM, Pajović SB. Antioxidant Enzymes in Brain Cortex of Rats Exposed to Acute, Chronic and Combined Stress. in Folia Biologica (Krakow). 2016;64(3):189-195.
doi:10.3409/fb64_3.189 .

Pejić, Snežana, Stojiljković, Vesna, Todorović, Ana, Gavrilović, Ljubica, Pavlović, Ivan, Popović, Nataša M., Pajović, Snežana B., "Antioxidant Enzymes in Brain Cortex of Rats Exposed to Acute, Chronic and Combined Stress" in Folia Biologica (Krakow), 64, no. 3 (2016):189-195,
https://doi.org/10.3409/fb64_3.189 . .

TY  - JOUR
AU  - Pejić, Snežana
AU  - Todorović, Ana
AU  - Stojiljković, Vesna
AU  - Pavlović, Ivan
AU  - Gavrilović, Ljubica
AU  - Popović, Nataša M.
AU  - Pajović, Snežana B.
PY  - 2016
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/1455
AB  - Endometrial tissue is under a strong influence of sex hormones. These hormones are considered as developmental factors of endometrial hyperplasia and endometrial cancer. We examined the influence of gonadotropins (follicle-stimulating and luteinizing hormone) and sex hormones (estradiol, progesterone) on oxidant/antioxidant parameters in blood and endometrial tissue of women with complex endometrial hyperplasia. In blood, superoxide dismutase activity was significantly higher in luteal phase and postmenopause compared to the follicular phase. A significant phase-related difference of glutathione peroxidase and glutathione reductase activity was recorded in the endometrium. Both enzymes had lower activity in luteal phase and postmenopause compared to the follicular phase. The linear regression analysis of individual hormonal variables against antioxidant parameters showed negative correlation between glutathione peroxidase activity and gonadotropin concentrations in the endometrium. The regression of hyperplastic to normal endometrium is the purpose of conservative treatment based on administration of progestogens or gonadotropin-releasing hormone analogues. Our findings indicate that gonadotropins influence the antioxidant enzymes activity in women with complex endometrial hyperplasia, which may affect disease development. Further studies are needed to clarify the molecular basis of hormone action on antioxidant system that may potentially initiate a development of treatments based onredox-dependentmechanism.
T2  - Cellular and Molecular Biology
T1  - Antioxidant status and sex hormones in women with complex endometrial hyperplasia
VL  - 62
IS  - 11
SP  - 51
EP  - 56
DO  - 10.14715/cmb/2016.62.11.9
ER  - 

@article{
author = "Pejić, Snežana and Todorović, Ana and Stojiljković, Vesna and Pavlović, Ivan and Gavrilović, Ljubica and Popović, Nataša M. and Pajović, Snežana B.",
year = "2016",
abstract = "Endometrial tissue is under a strong influence of sex hormones. These hormones are considered as developmental factors of endometrial hyperplasia and endometrial cancer. We examined the influence of gonadotropins (follicle-stimulating and luteinizing hormone) and sex hormones (estradiol, progesterone) on oxidant/antioxidant parameters in blood and endometrial tissue of women with complex endometrial hyperplasia. In blood, superoxide dismutase activity was significantly higher in luteal phase and postmenopause compared to the follicular phase. A significant phase-related difference of glutathione peroxidase and glutathione reductase activity was recorded in the endometrium. Both enzymes had lower activity in luteal phase and postmenopause compared to the follicular phase. The linear regression analysis of individual hormonal variables against antioxidant parameters showed negative correlation between glutathione peroxidase activity and gonadotropin concentrations in the endometrium. The regression of hyperplastic to normal endometrium is the purpose of conservative treatment based on administration of progestogens or gonadotropin-releasing hormone analogues. Our findings indicate that gonadotropins influence the antioxidant enzymes activity in women with complex endometrial hyperplasia, which may affect disease development. Further studies are needed to clarify the molecular basis of hormone action on antioxidant system that may potentially initiate a development of treatments based onredox-dependentmechanism.",
journal = "Cellular and Molecular Biology",
title = "Antioxidant status and sex hormones in women with complex endometrial hyperplasia",
volume = "62",
number = "11",
pages = "51-56",
doi = "10.14715/cmb/2016.62.11.9"
}

Pejić, S., Todorović, A., Stojiljković, V., Pavlović, I., Gavrilović, L., Popović, N. M.,& Pajović, S. B.. (2016). Antioxidant status and sex hormones in women with complex endometrial hyperplasia. in Cellular and Molecular Biology, 62(11), 51-56.
https://doi.org/10.14715/cmb/2016.62.11.9

Pejić S, Todorović A, Stojiljković V, Pavlović I, Gavrilović L, Popović NM, Pajović SB. Antioxidant status and sex hormones in women with complex endometrial hyperplasia. in Cellular and Molecular Biology. 2016;62(11):51-56.
doi:10.14715/cmb/2016.62.11.9 .

Pejić, Snežana, Todorović, Ana, Stojiljković, Vesna, Pavlović, Ivan, Gavrilović, Ljubica, Popović, Nataša M., Pajović, Snežana B., "Antioxidant status and sex hormones in women with complex endometrial hyperplasia" in Cellular and Molecular Biology, 62, no. 11 (2016):51-56,
https://doi.org/10.14715/cmb/2016.62.11.9 . .

TY  - CONF
AU  - Pavlović, Ivan
AU  - Todorović, Ana
AU  - Stojiljković, Vesna
AU  - Gavrilović, Ljubica
AU  - Popović, Nataša M.
AU  - Pajović, Snežana B.
AU  - Pejić, Snežana
PY  - 2016
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/7171
AB  - Renal cell carcinoma is the most common and the most lethal type of kidney cancer with the highest incidence in developed countries. At the moment of diagnosis, many patients already have developed metastases. Tobacco smoking, obesity, hypertension and occupational exposure are established risk factors. Superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) are antioxidant enzymes (AOE) that have a key role in protecting from reactive oxygen species (ROS) produced in pathological processes. We examined the antioxidant capacity of tumour tissue in patients with clear cell type of renal cell carcinoma. The results showed a significant decrease of AOE activities in the tumour tissue compared to the normal kidney tissue, indicating that the tumour tissue is under permanent oxidative stress. Renal cell carcinoma is highly resistant to radiation therapy, which is also associated with free radical production. Since the tumour tissue has impaired AO capacity, the findings of this study may contribute to the improvement of the potential therapeutic treatments.
C3  - RAD Conference Proceedings
T1  - Antioxidant Capacity of the Kidney Tissue in Patients with Renal Cell Carcinoma
SP  - 153
EP  - 155
DO  - 10.21175/RadProc.2016.36
ER  - 

@conference{
author = "Pavlović, Ivan and Todorović, Ana and Stojiljković, Vesna and Gavrilović, Ljubica and Popović, Nataša M. and Pajović, Snežana B. and Pejić, Snežana",
year = "2016",
abstract = "Renal cell carcinoma is the most common and the most lethal type of kidney cancer with the highest incidence in developed countries. At the moment of diagnosis, many patients already have developed metastases. Tobacco smoking, obesity, hypertension and occupational exposure are established risk factors. Superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) are antioxidant enzymes (AOE) that have a key role in protecting from reactive oxygen species (ROS) produced in pathological processes. We examined the antioxidant capacity of tumour tissue in patients with clear cell type of renal cell carcinoma. The results showed a significant decrease of AOE activities in the tumour tissue compared to the normal kidney tissue, indicating that the tumour tissue is under permanent oxidative stress. Renal cell carcinoma is highly resistant to radiation therapy, which is also associated with free radical production. Since the tumour tissue has impaired AO capacity, the findings of this study may contribute to the improvement of the potential therapeutic treatments.",
journal = "RAD Conference Proceedings",
title = "Antioxidant Capacity of the Kidney Tissue in Patients with Renal Cell Carcinoma",
pages = "153-155",
doi = "10.21175/RadProc.2016.36"
}

Pavlović, I., Todorović, A., Stojiljković, V., Gavrilović, L., Popović, N. M., Pajović, S. B.,& Pejić, S.. (2016). Antioxidant Capacity of the Kidney Tissue in Patients with Renal Cell Carcinoma. in RAD Conference Proceedings, 153-155.
https://doi.org/10.21175/RadProc.2016.36

Pavlović I, Todorović A, Stojiljković V, Gavrilović L, Popović NM, Pajović SB, Pejić S. Antioxidant Capacity of the Kidney Tissue in Patients with Renal Cell Carcinoma. in RAD Conference Proceedings. 2016;:153-155.
doi:10.21175/RadProc.2016.36 .

Pavlović, Ivan, Todorović, Ana, Stojiljković, Vesna, Gavrilović, Ljubica, Popović, Nataša M., Pajović, Snežana B., Pejić, Snežana, "Antioxidant Capacity of the Kidney Tissue in Patients with Renal Cell Carcinoma" in RAD Conference Proceedings (2016):153-155,
https://doi.org/10.21175/RadProc.2016.36 . .

TY  - CONF
AU  - Gavrilović, Ljubica
AU  - Stojiljković, Vesna
AU  - Dronjak Čučaković, Slađana
AU  - Popović, Nataša
AU  - Pejić, Snežana
AU  - Todorović, Ana
AU  - Pavlović, Ivan
AU  - Pajović, Snežana B.
PY  - 2015
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/11403
PB  - Belgrade : Serbian Neurocardiological Society
C3  - NEUROCARD 2015 : 7th Congress of Serbian neuroscience society with international participation, 6th International Symposium on Noninvasive Electrocardiology :  Program and the book of abstracts
T1  - Daily treadmill running maintains the sythesis of catecholamines on the basal level and decreases oxidative stress in the right and left heart auricles of chronically stressed rats
SP  - 92
UR  - https://hdl.handle.net/21.15107/rcub_vinar_11403
ER  - 

@conference{
author = "Gavrilović, Ljubica and Stojiljković, Vesna and Dronjak Čučaković, Slađana and Popović, Nataša and Pejić, Snežana and Todorović, Ana and Pavlović, Ivan and Pajović, Snežana B.",
year = "2015",
publisher = "Belgrade : Serbian Neurocardiological Society",
journal = "NEUROCARD 2015 : 7th Congress of Serbian neuroscience society with international participation, 6th International Symposium on Noninvasive Electrocardiology :  Program and the book of abstracts",
title = "Daily treadmill running maintains the sythesis of catecholamines on the basal level and decreases oxidative stress in the right and left heart auricles of chronically stressed rats",
pages = "92",
url = "https://hdl.handle.net/21.15107/rcub_vinar_11403"
}

Gavrilović, L., Stojiljković, V., Dronjak Čučaković, S., Popović, N., Pejić, S., Todorović, A., Pavlović, I.,& Pajović, S. B.. (2015). Daily treadmill running maintains the sythesis of catecholamines on the basal level and decreases oxidative stress in the right and left heart auricles of chronically stressed rats. in NEUROCARD 2015 : 7th Congress of Serbian neuroscience society with international participation, 6th International Symposium on Noninvasive Electrocardiology :  Program and the book of abstracts
Belgrade : Serbian Neurocardiological Society., 92.
https://hdl.handle.net/21.15107/rcub_vinar_11403

Gavrilović L, Stojiljković V, Dronjak Čučaković S, Popović N, Pejić S, Todorović A, Pavlović I, Pajović SB. Daily treadmill running maintains the sythesis of catecholamines on the basal level and decreases oxidative stress in the right and left heart auricles of chronically stressed rats. in NEUROCARD 2015 : 7th Congress of Serbian neuroscience society with international participation, 6th International Symposium on Noninvasive Electrocardiology :  Program and the book of abstracts. 2015;:92.
https://hdl.handle.net/21.15107/rcub_vinar_11403 .

Gavrilović, Ljubica, Stojiljković, Vesna, Dronjak Čučaković, Slađana, Popović, Nataša, Pejić, Snežana, Todorović, Ana, Pavlović, Ivan, Pajović, Snežana B., "Daily treadmill running maintains the sythesis of catecholamines on the basal level and decreases oxidative stress in the right and left heart auricles of chronically stressed rats" in NEUROCARD 2015 : 7th Congress of Serbian neuroscience society with international participation, 6th International Symposium on Noninvasive Electrocardiology :  Program and the book of abstracts (2015):92,
https://hdl.handle.net/21.15107/rcub_vinar_11403 .

TY  - JOUR
AU  - Pejić, Snežana
AU  - Stojiljković, Vesna
AU  - Todorović, Ana
AU  - Gavrilović, Ljubica
AU  - Popović, Nataša M.
AU  - Pavlović, Ivan
AU  - Pajović, Snežana B.
PY  - 2015
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/498
AB  - Cancer of the reproductive tract is an important cause of morbidity and mortality among women worldwide. In this study we evaluated the influence of diagnostic categories, age and reproductive factors on antioxidant enzymes and lipid hydroperoxides in the blood of gynaecological patients diagnosed with endometrial polyp, myoma, hyperplasia simplex, hyperplasia complex and endometrial adenocarcinoma. Multivariate regression analysis was used to assess the association of diagnosis, age, parity, abortions and abnormal uterine bleeding with the examined parameters. Diagnosis provided the best predictive model for superoxide dismutase, catalase and glutathione peroxidase activities, and also for the lipid hydroperoxide level. Abortions fitted the best predictive model for superoxide dismutase activity. A significant correlation was also found between the predictor variables themselves. This study showed that reproductive and other factors may be associated, at least partially, with antioxidant capacity and ability to defend against the oxidative damage in gynaecological patients with various diagnoses.
T2  - Folia Biologica
T1  - Antioxidant Status in Blood of Gynaecological Patients: Influence of Diagnosis and Reproductive Factors
VL  - 61
IS  - 1
SP  - 26
EP  - 32
UR  - https://hdl.handle.net/21.15107/rcub_vinar_498
ER  - 

@article{
author = "Pejić, Snežana and Stojiljković, Vesna and Todorović, Ana and Gavrilović, Ljubica and Popović, Nataša M. and Pavlović, Ivan and Pajović, Snežana B.",
year = "2015",
abstract = "Cancer of the reproductive tract is an important cause of morbidity and mortality among women worldwide. In this study we evaluated the influence of diagnostic categories, age and reproductive factors on antioxidant enzymes and lipid hydroperoxides in the blood of gynaecological patients diagnosed with endometrial polyp, myoma, hyperplasia simplex, hyperplasia complex and endometrial adenocarcinoma. Multivariate regression analysis was used to assess the association of diagnosis, age, parity, abortions and abnormal uterine bleeding with the examined parameters. Diagnosis provided the best predictive model for superoxide dismutase, catalase and glutathione peroxidase activities, and also for the lipid hydroperoxide level. Abortions fitted the best predictive model for superoxide dismutase activity. A significant correlation was also found between the predictor variables themselves. This study showed that reproductive and other factors may be associated, at least partially, with antioxidant capacity and ability to defend against the oxidative damage in gynaecological patients with various diagnoses.",
journal = "Folia Biologica",
title = "Antioxidant Status in Blood of Gynaecological Patients: Influence of Diagnosis and Reproductive Factors",
volume = "61",
number = "1",
pages = "26-32",
url = "https://hdl.handle.net/21.15107/rcub_vinar_498"
}

Pejić, S., Stojiljković, V., Todorović, A., Gavrilović, L., Popović, N. M., Pavlović, I.,& Pajović, S. B.. (2015). Antioxidant Status in Blood of Gynaecological Patients: Influence of Diagnosis and Reproductive Factors. in Folia Biologica, 61(1), 26-32.
https://hdl.handle.net/21.15107/rcub_vinar_498

Pejić S, Stojiljković V, Todorović A, Gavrilović L, Popović NM, Pavlović I, Pajović SB. Antioxidant Status in Blood of Gynaecological Patients: Influence of Diagnosis and Reproductive Factors. in Folia Biologica. 2015;61(1):26-32.
https://hdl.handle.net/21.15107/rcub_vinar_498 .

Pejić, Snežana, Stojiljković, Vesna, Todorović, Ana, Gavrilović, Ljubica, Popović, Nataša M., Pavlović, Ivan, Pajović, Snežana B., "Antioxidant Status in Blood of Gynaecological Patients: Influence of Diagnosis and Reproductive Factors" in Folia Biologica, 61, no. 1 (2015):26-32,
https://hdl.handle.net/21.15107/rcub_vinar_498 .

TY  - JOUR
AU  - Todorović, Ana
AU  - Pejić, Snežana
AU  - Stojiljković, Vesna
AU  - Gavrilović, Ljubica
AU  - Popović, Nataša M.
AU  - Pavlović, Ivan
AU  - Saičić, Zorica S.
AU  - Pajović, Snežana B.
PY  - 2015
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/815
AB  - Purpose Previously, we examined manganese superoxide dismutase (MnSOD), copper-zinc superoxide dismutase (CuZnSOD), and catalase (CAT) activities in rat brain irradiated with 2 or 3 Gy of gamma-rays. The results indicated that lower MnSOD activity and inducibility found in hippocampus might explain higher radiosensitivity of this brain region. Thus, in this study, we wanted to determine changes of MnSOD, CuZnSOD, and CAT activities after dose of 5 Gy and to find out if differences in MnSOD activity are caused by changes in its expression. Heads of 4-day-old female rats were irradiated with gamma-rays, using Co-60. Animals were sacrificed 1/24 h after exposure. Hippocampus and cortex tissues were prepared for enzyme activity measurements and Western blot analysis. One hour after exposure, gamma-rays significantly decreased MnSOD activity in both examined brain regions. Twenty-four hours later, MnSOD recovery showed dose and regional dependence. It was weaker at higher doses and in hippocampal region. MnSOD expression changed in the similar manner as MnSOD activity only at lower doses of gamma-rays. In both examined brain regions, gamma radiation significantly decreased CuZnSOD activity and did not change activity of CAT. Our results confirmed that MnSOD plays an important role in different regional radiosensitivity but also showed that depending on dose, radiation affects MnSOD level by utterly different mechanisms. Postradiation changes of CuZnSOD and CAT are not regionally specific and therefore, cannot account for the different radiosensitivity of the hippocampus and cortex.
PB  - Springer Nature
T2  - Childs Nervous System
T1  - Antioxidative enzymes in irradiated rat brain-indicators of different regional radiosensitivity
VL  - 31
IS  - 12
SP  - 2249
EP  - 2256
DO  - 10.1007/s00381-015-2807-2
ER  - 

@article{
author = "Todorović, Ana and Pejić, Snežana and Stojiljković, Vesna and Gavrilović, Ljubica and Popović, Nataša M. and Pavlović, Ivan and Saičić, Zorica S. and Pajović, Snežana B.",
year = "2015",
abstract = "Purpose Previously, we examined manganese superoxide dismutase (MnSOD), copper-zinc superoxide dismutase (CuZnSOD), and catalase (CAT) activities in rat brain irradiated with 2 or 3 Gy of gamma-rays. The results indicated that lower MnSOD activity and inducibility found in hippocampus might explain higher radiosensitivity of this brain region. Thus, in this study, we wanted to determine changes of MnSOD, CuZnSOD, and CAT activities after dose of 5 Gy and to find out if differences in MnSOD activity are caused by changes in its expression. Heads of 4-day-old female rats were irradiated with gamma-rays, using Co-60. Animals were sacrificed 1/24 h after exposure. Hippocampus and cortex tissues were prepared for enzyme activity measurements and Western blot analysis. One hour after exposure, gamma-rays significantly decreased MnSOD activity in both examined brain regions. Twenty-four hours later, MnSOD recovery showed dose and regional dependence. It was weaker at higher doses and in hippocampal region. MnSOD expression changed in the similar manner as MnSOD activity only at lower doses of gamma-rays. In both examined brain regions, gamma radiation significantly decreased CuZnSOD activity and did not change activity of CAT. Our results confirmed that MnSOD plays an important role in different regional radiosensitivity but also showed that depending on dose, radiation affects MnSOD level by utterly different mechanisms. Postradiation changes of CuZnSOD and CAT are not regionally specific and therefore, cannot account for the different radiosensitivity of the hippocampus and cortex.",
publisher = "Springer Nature",
journal = "Childs Nervous System",
title = "Antioxidative enzymes in irradiated rat brain-indicators of different regional radiosensitivity",
volume = "31",
number = "12",
pages = "2249-2256",
doi = "10.1007/s00381-015-2807-2"
}

Todorović, A., Pejić, S., Stojiljković, V., Gavrilović, L., Popović, N. M., Pavlović, I., Saičić, Z. S.,& Pajović, S. B.. (2015). Antioxidative enzymes in irradiated rat brain-indicators of different regional radiosensitivity. in Childs Nervous System
Springer Nature., 31(12), 2249-2256.
https://doi.org/10.1007/s00381-015-2807-2

Todorović A, Pejić S, Stojiljković V, Gavrilović L, Popović NM, Pavlović I, Saičić ZS, Pajović SB. Antioxidative enzymes in irradiated rat brain-indicators of different regional radiosensitivity. in Childs Nervous System. 2015;31(12):2249-2256.
doi:10.1007/s00381-015-2807-2 .

Todorović, Ana, Pejić, Snežana, Stojiljković, Vesna, Gavrilović, Ljubica, Popović, Nataša M., Pavlović, Ivan, Saičić, Zorica S., Pajović, Snežana B., "Antioxidative enzymes in irradiated rat brain-indicators of different regional radiosensitivity" in Childs Nervous System, 31, no. 12 (2015):2249-2256,
https://doi.org/10.1007/s00381-015-2807-2 . .