TY  - CONF
AU  - Matijević, Milica
AU  - Stepić, Milutin
AU  - Radojičić, M.
AU  - Petković, M.
AU  - Nešić, M. D.
PY  - 2021
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10910
AB  - TiO2 nanoparticles (NPs) have great potential for implementing photodynamic therapy (PDT) as a part of drug delivery therapeutical systems. PDT is an emerging anti-cancer therapy that involves the administration of photosensitizer (PS), which undergoes reversible changes upon light exposure. Next, PS can release a cytostatic drugand/or transfer its energy to molecular oxygen, generating reactive oxygen species (ROS), consequentlyleading to cancer cell ablation [1]. In this work, we assessed photocytotoxicity to the HeLa cell line of the nanocarrier/drug complexes– nanocomposite systems (NCSs) made of different types of carriers, TiO2 NPs, for the delivery of Ru complex (cis-dichlorobis (2,2'-bipyridyl-4,4'-dicarboxylic acid)ruthenium(II). One tested NCS consists of colloid TiO2 NPs, whereas the other consists of the TiO2prolatenanospheroids (PNSs). Previously in our work, both TiO2 NPs demonstrated good biocompatibility in the dark [2,3], whereas the Ru complex exhibited notable anti-proliferative, genotoxic, and antitumor effects [4].AsTiO2 NPs are photo-active in the UV range, and the Ru complex absorbs in both UV and visible spectrum [3],herein, we havedetermined the optical bandgaps of the synthesized NCSs withTauc’s plot. Calculated bandgaps of the synthesized NCSs proved that the Ru complex extends the responsiveness of TiO2 to visible light while acts as a medicament in photo-active NCSs, allowing the absorption of the NCSs in the visible range. Thus, we have examined the photocytotoxicity of the combined treatment of the HeLa cells with NCSs and visible light. The preliminary results show that visible light, which is not harmful when applied alone to the cells, can effectively induce a cytotoxic effect in the combined therapy with the NCSs.
PB  - Belgrade : Institute of Physics Belgrade
C3  - PHOTONICA2021 : 8th International School and Conference on Photonics and HEMMAGINERO workshop : Abstracts of Tutorial, Keynote, Invited Lectures, Progress Reports and Contributed Papers; August 23-27, 2021; Belgrade
T1  - Visible light-responsiveness of the nanocarrier/drug complex based on the TiO2 nanoparticles and Ru complex
SP  - 109
UR  - https://hdl.handle.net/21.15107/rcub_vinar_10910
ER  - 

@conference{
author = "Matijević, Milica and Stepić, Milutin and Radojičić, M. and Petković, M. and Nešić, M. D.",
year = "2021",
abstract = "TiO2 nanoparticles (NPs) have great potential for implementing photodynamic therapy (PDT) as a part of drug delivery therapeutical systems. PDT is an emerging anti-cancer therapy that involves the administration of photosensitizer (PS), which undergoes reversible changes upon light exposure. Next, PS can release a cytostatic drugand/or transfer its energy to molecular oxygen, generating reactive oxygen species (ROS), consequentlyleading to cancer cell ablation [1]. In this work, we assessed photocytotoxicity to the HeLa cell line of the nanocarrier/drug complexes– nanocomposite systems (NCSs) made of different types of carriers, TiO2 NPs, for the delivery of Ru complex (cis-dichlorobis (2,2'-bipyridyl-4,4'-dicarboxylic acid)ruthenium(II). One tested NCS consists of colloid TiO2 NPs, whereas the other consists of the TiO2prolatenanospheroids (PNSs). Previously in our work, both TiO2 NPs demonstrated good biocompatibility in the dark [2,3], whereas the Ru complex exhibited notable anti-proliferative, genotoxic, and antitumor effects [4].AsTiO2 NPs are photo-active in the UV range, and the Ru complex absorbs in both UV and visible spectrum [3],herein, we havedetermined the optical bandgaps of the synthesized NCSs withTauc’s plot. Calculated bandgaps of the synthesized NCSs proved that the Ru complex extends the responsiveness of TiO2 to visible light while acts as a medicament in photo-active NCSs, allowing the absorption of the NCSs in the visible range. Thus, we have examined the photocytotoxicity of the combined treatment of the HeLa cells with NCSs and visible light. The preliminary results show that visible light, which is not harmful when applied alone to the cells, can effectively induce a cytotoxic effect in the combined therapy with the NCSs.",
publisher = "Belgrade : Institute of Physics Belgrade",
journal = "PHOTONICA2021 : 8th International School and Conference on Photonics and HEMMAGINERO workshop : Abstracts of Tutorial, Keynote, Invited Lectures, Progress Reports and Contributed Papers; August 23-27, 2021; Belgrade",
title = "Visible light-responsiveness of the nanocarrier/drug complex based on the TiO2 nanoparticles and Ru complex",
pages = "109",
url = "https://hdl.handle.net/21.15107/rcub_vinar_10910"
}

Matijević, M., Stepić, M., Radojičić, M., Petković, M.,& Nešić, M. D.. (2021). Visible light-responsiveness of the nanocarrier/drug complex based on the TiO2 nanoparticles and Ru complex. in PHOTONICA2021 : 8th International School and Conference on Photonics and HEMMAGINERO workshop : Abstracts of Tutorial, Keynote, Invited Lectures, Progress Reports and Contributed Papers; August 23-27, 2021; Belgrade
Belgrade : Institute of Physics Belgrade., 109.
https://hdl.handle.net/21.15107/rcub_vinar_10910

Matijević M, Stepić M, Radojičić M, Petković M, Nešić MD. Visible light-responsiveness of the nanocarrier/drug complex based on the TiO2 nanoparticles and Ru complex. in PHOTONICA2021 : 8th International School and Conference on Photonics and HEMMAGINERO workshop : Abstracts of Tutorial, Keynote, Invited Lectures, Progress Reports and Contributed Papers; August 23-27, 2021; Belgrade. 2021;:109.
https://hdl.handle.net/21.15107/rcub_vinar_10910 .

Matijević, Milica, Stepić, Milutin, Radojičić, M., Petković, M., Nešić, M. D., "Visible light-responsiveness of the nanocarrier/drug complex based on the TiO2 nanoparticles and Ru complex" in PHOTONICA2021 : 8th International School and Conference on Photonics and HEMMAGINERO workshop : Abstracts of Tutorial, Keynote, Invited Lectures, Progress Reports and Contributed Papers; August 23-27, 2021; Belgrade (2021):109,
https://hdl.handle.net/21.15107/rcub_vinar_10910 .