TY  - CONF
AU  - Trtić-Petrović, Tatjana M.
AU  - Kumrić, Ksenija
AU  - Koumarianou, Eftichia
AU  - Archimandritis, Spyridon
AU  - Čomor, Jožef J.
PY  - 2006
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/2716
C3  - European Journal of Nuclear Medicine and Molecular Imaging
T1  - Membrane extraction - a new method for purification of labeled compounds
VL  - 33
SP  - S308
EP  - S308
UR  - https://hdl.handle.net/21.15107/rcub_vinar_2716
ER  - 

@conference{
author = "Trtić-Petrović, Tatjana M. and Kumrić, Ksenija and Koumarianou, Eftichia and Archimandritis, Spyridon and Čomor, Jožef J.",
year = "2006",
journal = "European Journal of Nuclear Medicine and Molecular Imaging",
title = "Membrane extraction - a new method for purification of labeled compounds",
volume = "33",
pages = "S308-S308",
url = "https://hdl.handle.net/21.15107/rcub_vinar_2716"
}

Trtić-Petrović, T. M., Kumrić, K., Koumarianou, E., Archimandritis, S.,& Čomor, J. J.. (2006). Membrane extraction - a new method for purification of labeled compounds. in European Journal of Nuclear Medicine and Molecular Imaging, 33, S308-S308.
https://hdl.handle.net/21.15107/rcub_vinar_2716

Trtić-Petrović TM, Kumrić K, Koumarianou E, Archimandritis S, Čomor JJ. Membrane extraction - a new method for purification of labeled compounds. in European Journal of Nuclear Medicine and Molecular Imaging. 2006;33:S308-S308.
https://hdl.handle.net/21.15107/rcub_vinar_2716 .

Trtić-Petrović, Tatjana M., Kumrić, Ksenija, Koumarianou, Eftichia, Archimandritis, Spyridon, Čomor, Jožef J., "Membrane extraction - a new method for purification of labeled compounds" in European Journal of Nuclear Medicine and Molecular Imaging, 33 (2006):S308-S308,
https://hdl.handle.net/21.15107/rcub_vinar_2716 .

TY  - JOUR
AU  - Kumrić, Ksenija
AU  - Trtić-Petrović, Tatjana M.
AU  - Koumarianou, Eftichia
AU  - Archimandritis, Spyridon
AU  - Čomor, Jožef J.
PY  - 2006
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/3111
AB  - Permeation of Lu-177(III) through supported hexane membrane containing di-(2-ethythexyl)phosphoric acid (DEHPA) as a carrier has been studied. The donor solution was 0.2 mol dm(-3) ammonium acetate buffer, pH 5.0-5.5, that is optimal for peptide labeling, and the acceptor solution was 2 mol dm(-3) HCl. A miniaturized supported liquid membrane (SLM) contactor with 10 mu l donor and acceptor channel and ultra thin, flat poly(tetrafluoroethene) laminated on polyester fleece (PTFE) was applied in the work reported herein. The donor phase was pumped continuously through the donor channel, while the acceptor was stagnant during the SLM extraction. The influences of carrier concentration and donor flow rate on extraction of Lu-177(III) have been investigated. The results are discussed in the term of mass transfer coefficient, mass transfer resistance and extraction efficiency. Based on the experimental results of SLM extraction of Lu-177(III), this technique has been applied for the separation of free radionuclide from the labeled peptide as a purification procedure within the production of the radiopharmaceutical. An analog of somatostatin, lanreotide, which was conjugated with chelating moiety 1,4,7,10-tetraazacyclododecane-N,N,N,N-tetraacetic acid (DOTA) was labeled with Lu-177(III). The characterization of the labeled conjugate as well as the complexation yield and the efficiency of purification by membrane extraction were carried out by HPLC analysis. (c) 2006 Elsevier B.V. All rights reserved.
T2  - Separation and Purification Technology
T1  - Supported liquid membrane extraction of Lu-177(III) with DEHPA and its application for purification of Lu-177-DOTA-lanreotide
VL  - 51
IS  - 3
SP  - 310
EP  - 317
DO  - 10.1016/j.seppur.2006.02.011
ER  - 

@article{
author = "Kumrić, Ksenija and Trtić-Petrović, Tatjana M. and Koumarianou, Eftichia and Archimandritis, Spyridon and Čomor, Jožef J.",
year = "2006",
abstract = "Permeation of Lu-177(III) through supported hexane membrane containing di-(2-ethythexyl)phosphoric acid (DEHPA) as a carrier has been studied. The donor solution was 0.2 mol dm(-3) ammonium acetate buffer, pH 5.0-5.5, that is optimal for peptide labeling, and the acceptor solution was 2 mol dm(-3) HCl. A miniaturized supported liquid membrane (SLM) contactor with 10 mu l donor and acceptor channel and ultra thin, flat poly(tetrafluoroethene) laminated on polyester fleece (PTFE) was applied in the work reported herein. The donor phase was pumped continuously through the donor channel, while the acceptor was stagnant during the SLM extraction. The influences of carrier concentration and donor flow rate on extraction of Lu-177(III) have been investigated. The results are discussed in the term of mass transfer coefficient, mass transfer resistance and extraction efficiency. Based on the experimental results of SLM extraction of Lu-177(III), this technique has been applied for the separation of free radionuclide from the labeled peptide as a purification procedure within the production of the radiopharmaceutical. An analog of somatostatin, lanreotide, which was conjugated with chelating moiety 1,4,7,10-tetraazacyclododecane-N,N,N,N-tetraacetic acid (DOTA) was labeled with Lu-177(III). The characterization of the labeled conjugate as well as the complexation yield and the efficiency of purification by membrane extraction were carried out by HPLC analysis. (c) 2006 Elsevier B.V. All rights reserved.",
journal = "Separation and Purification Technology",
title = "Supported liquid membrane extraction of Lu-177(III) with DEHPA and its application for purification of Lu-177-DOTA-lanreotide",
volume = "51",
number = "3",
pages = "310-317",
doi = "10.1016/j.seppur.2006.02.011"
}

Kumrić, K., Trtić-Petrović, T. M., Koumarianou, E., Archimandritis, S.,& Čomor, J. J.. (2006). Supported liquid membrane extraction of Lu-177(III) with DEHPA and its application for purification of Lu-177-DOTA-lanreotide. in Separation and Purification Technology, 51(3), 310-317.
https://doi.org/10.1016/j.seppur.2006.02.011

Kumrić K, Trtić-Petrović TM, Koumarianou E, Archimandritis S, Čomor JJ. Supported liquid membrane extraction of Lu-177(III) with DEHPA and its application for purification of Lu-177-DOTA-lanreotide. in Separation and Purification Technology. 2006;51(3):310-317.
doi:10.1016/j.seppur.2006.02.011 .

Kumrić, Ksenija, Trtić-Petrović, Tatjana M., Koumarianou, Eftichia, Archimandritis, Spyridon, Čomor, Jožef J., "Supported liquid membrane extraction of Lu-177(III) with DEHPA and its application for purification of Lu-177-DOTA-lanreotide" in Separation and Purification Technology, 51, no. 3 (2006):310-317,
https://doi.org/10.1016/j.seppur.2006.02.011 . .

TY  - CONF
AU  - Koumarianou, Eftichia
AU  - Bouziotis, Penelope
AU  - Kumrić, Ksenija
AU  - Fragogeorgi, I
AU  - Loudos, GK
AU  - Mitsokapas, N
AU  - Varvarigou, AD
AU  - Archimandritis, Spyridon
PY  - 2004
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/6463
C3  - European Journal of Nuclear Medicine and Molecular Imaging
T1  - Production of Lu-177 at the NCSR Demokritos. Labeling of biomolecules with Lutetium-177 and purification of the labeled product
VL  - 31
SP  - S389
EP  - S389
UR  - https://hdl.handle.net/21.15107/rcub_vinar_6463
ER  - 

@conference{
author = "Koumarianou, Eftichia and Bouziotis, Penelope and Kumrić, Ksenija and Fragogeorgi, I and Loudos, GK and Mitsokapas, N and Varvarigou, AD and Archimandritis, Spyridon",
year = "2004",
journal = "European Journal of Nuclear Medicine and Molecular Imaging",
title = "Production of Lu-177 at the NCSR Demokritos. Labeling of biomolecules with Lutetium-177 and purification of the labeled product",
volume = "31",
pages = "S389-S389",
url = "https://hdl.handle.net/21.15107/rcub_vinar_6463"
}

Koumarianou, E., Bouziotis, P., Kumrić, K., Fragogeorgi, I., Loudos, G., Mitsokapas, N., Varvarigou, A.,& Archimandritis, S.. (2004). Production of Lu-177 at the NCSR Demokritos. Labeling of biomolecules with Lutetium-177 and purification of the labeled product. in European Journal of Nuclear Medicine and Molecular Imaging, 31, S389-S389.
https://hdl.handle.net/21.15107/rcub_vinar_6463

Koumarianou E, Bouziotis P, Kumrić K, Fragogeorgi I, Loudos G, Mitsokapas N, Varvarigou A, Archimandritis S. Production of Lu-177 at the NCSR Demokritos. Labeling of biomolecules with Lutetium-177 and purification of the labeled product. in European Journal of Nuclear Medicine and Molecular Imaging. 2004;31:S389-S389.
https://hdl.handle.net/21.15107/rcub_vinar_6463 .

Koumarianou, Eftichia, Bouziotis, Penelope, Kumrić, Ksenija, Fragogeorgi, I, Loudos, GK, Mitsokapas, N, Varvarigou, AD, Archimandritis, Spyridon, "Production of Lu-177 at the NCSR Demokritos. Labeling of biomolecules with Lutetium-177 and purification of the labeled product" in European Journal of Nuclear Medicine and Molecular Imaging, 31 (2004):S389-S389,
https://hdl.handle.net/21.15107/rcub_vinar_6463 .

TY  - JOUR
AU  - Fani, M
AU  - Vranješ, Sanja
AU  - Archimandritis, Spyridon
AU  - Potamianos, S
AU  - Xanthopoulos, S
AU  - Bouziotis, Penelope
AU  - Varvarigou, AD
PY  - 2002
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/2557
AB  - The labeling of a monoclonal (anti-CEA) and a polyclonal (IgG) antibody with Sm-153 has been investigated, using the bicyclic anhydride of DTPA (cDTPAa) as the chelating agent. The radiochemical study was performed using a combination of radioanalytical techniques (gel filtration, HPLC, ITLC-SG and SDS-PAGE). Optimization of factors affecting labeling (pH, Ab, Ab-DTPA concentration, etc.) leads to a labeling yield higher than 90%. Biodistribution studies in normal mice showed slow blood clearance and high uptake into the liver, kidney and lungs. (C) 2002 Elsevier Science Ltd. All rights reserved.
T2  - Applied Radiation and Isotopes
T1  - Labeling of monoclonal antibodies with Sm-153 for potential use in radioimmunotherapy
VL  - 57
IS  - 5
SP  - 665
EP  - 674
DO  - 10.1016/S0969-8043(02)00181-1
ER  - 

@article{
author = "Fani, M and Vranješ, Sanja and Archimandritis, Spyridon and Potamianos, S and Xanthopoulos, S and Bouziotis, Penelope and Varvarigou, AD",
year = "2002",
abstract = "The labeling of a monoclonal (anti-CEA) and a polyclonal (IgG) antibody with Sm-153 has been investigated, using the bicyclic anhydride of DTPA (cDTPAa) as the chelating agent. The radiochemical study was performed using a combination of radioanalytical techniques (gel filtration, HPLC, ITLC-SG and SDS-PAGE). Optimization of factors affecting labeling (pH, Ab, Ab-DTPA concentration, etc.) leads to a labeling yield higher than 90%. Biodistribution studies in normal mice showed slow blood clearance and high uptake into the liver, kidney and lungs. (C) 2002 Elsevier Science Ltd. All rights reserved.",
journal = "Applied Radiation and Isotopes",
title = "Labeling of monoclonal antibodies with Sm-153 for potential use in radioimmunotherapy",
volume = "57",
number = "5",
pages = "665-674",
doi = "10.1016/S0969-8043(02)00181-1"
}

Fani, M., Vranješ, S., Archimandritis, S., Potamianos, S., Xanthopoulos, S., Bouziotis, P.,& Varvarigou, A.. (2002). Labeling of monoclonal antibodies with Sm-153 for potential use in radioimmunotherapy. in Applied Radiation and Isotopes, 57(5), 665-674.
https://doi.org/10.1016/S0969-8043(02)00181-1

Fani M, Vranješ S, Archimandritis S, Potamianos S, Xanthopoulos S, Bouziotis P, Varvarigou A. Labeling of monoclonal antibodies with Sm-153 for potential use in radioimmunotherapy. in Applied Radiation and Isotopes. 2002;57(5):665-674.
doi:10.1016/S0969-8043(02)00181-1 .

Fani, M, Vranješ, Sanja, Archimandritis, Spyridon, Potamianos, S, Xanthopoulos, S, Bouziotis, Penelope, Varvarigou, AD, "Labeling of monoclonal antibodies with Sm-153 for potential use in radioimmunotherapy" in Applied Radiation and Isotopes, 57, no. 5 (2002):665-674,
https://doi.org/10.1016/S0969-8043(02)00181-1 . .

TY  - JOUR
AU  - Trtić-Petrović, Tatjana M.
AU  - Vladisavljević, Goran T.
AU  - Archimandritis, Spyridon
AU  - Varvarigou, A
AU  - Čomor, Jožef J.
PY  - 2001
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/2456
AB  - The influence of module arrangements on solvent extraction of thallium(III) from NaCl/H2SO4 solution into butyl acetate has been studied using two laboratory-made modules consisting of hydrophobic polypropylene hollow fibers. The aqueous phase was recirculated between the module(s) and a mixed reservoir, and the organic phase was stagnant on the shell side. It was found that the extraction of Tl([Il) from aqueous phase strictly depends on aqueous flow rate and module arrangement. The results obtained are discussed in terms of the fraction of TI(III) removed from the aqueous phase reservoir, the flux of TI(III) through the interfacial area, and the best arrangement of modules for the production process of the radiopharmaceutical (TlCl)-Tl-201.
T2  - Journal of Separation Science
T1  - Influence of module arrangements on solvent extraction of thallium(III) in hollow fiber contactors
VL  - 24
IS  - 7
SP  - 519
EP  - 525
DO  - 10.1002/1615-9314(20010801)24:7 LT 519::AID-JSSC519 GT 3.0.CO;2-N
ER  - 

@article{
author = "Trtić-Petrović, Tatjana M. and Vladisavljević, Goran T. and Archimandritis, Spyridon and Varvarigou, A and Čomor, Jožef J.",
year = "2001",
abstract = "The influence of module arrangements on solvent extraction of thallium(III) from NaCl/H2SO4 solution into butyl acetate has been studied using two laboratory-made modules consisting of hydrophobic polypropylene hollow fibers. The aqueous phase was recirculated between the module(s) and a mixed reservoir, and the organic phase was stagnant on the shell side. It was found that the extraction of Tl([Il) from aqueous phase strictly depends on aqueous flow rate and module arrangement. The results obtained are discussed in terms of the fraction of TI(III) removed from the aqueous phase reservoir, the flux of TI(III) through the interfacial area, and the best arrangement of modules for the production process of the radiopharmaceutical (TlCl)-Tl-201.",
journal = "Journal of Separation Science",
title = "Influence of module arrangements on solvent extraction of thallium(III) in hollow fiber contactors",
volume = "24",
number = "7",
pages = "519-525",
doi = "10.1002/1615-9314(20010801)24:7 LT 519::AID-JSSC519 GT 3.0.CO;2-N"
}

Trtić-Petrović, T. M., Vladisavljević, G. T., Archimandritis, S., Varvarigou, A.,& Čomor, J. J.. (2001). Influence of module arrangements on solvent extraction of thallium(III) in hollow fiber contactors. in Journal of Separation Science, 24(7), 519-525.
https://doi.org/10.1002/1615-9314(20010801)24:7 LT 519::AID-JSSC519 GT 3.0.CO;2-N

Trtić-Petrović TM, Vladisavljević GT, Archimandritis S, Varvarigou A, Čomor JJ. Influence of module arrangements on solvent extraction of thallium(III) in hollow fiber contactors. in Journal of Separation Science. 2001;24(7):519-525.
doi:10.1002/1615-9314(20010801)24:7 LT 519::AID-JSSC519 GT 3.0.CO;2-N .

Trtić-Petrović, Tatjana M., Vladisavljević, Goran T., Archimandritis, Spyridon, Varvarigou, A, Čomor, Jožef J., "Influence of module arrangements on solvent extraction of thallium(III) in hollow fiber contactors" in Journal of Separation Science, 24, no. 7 (2001):519-525,
https://doi.org/10.1002/1615-9314(20010801)24:7 LT 519::AID-JSSC519 GT 3.0.CO;2-N . .