Bugarčić, Živadin D.

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  • Bugarčić, Živadin D. (10)
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Author's Bibliography

New dinuclear palladium(II) complexes: Studies of the nucleophilic substitution reactions, DNA/BSA interactions and cytotoxic activity

Cocic, Dugan; Jovanović, Snežana; Nišavić, Marija; Baskic, Dejan; Todorović, Danijela V.; Popovic, Suzana; Bugarčić, Živadin D.; Petrović, Biljana

(2017)

TY  - JOUR
AU  - Cocic, Dugan
AU  - Jovanović, Snežana
AU  - Nišavić, Marija
AU  - Baskic, Dejan
AU  - Todorović, Danijela V.
AU  - Popovic, Suzana
AU  - Bugarčić, Živadin D.
AU  - Petrović, Biljana
PY  - 2017
UR  - http://vinar.vin.bg.ac.rs/handle/123456789/1758
AB  - Six new dinuclear Pd(II) complexes, [{Pd(2,2-bipy)Cl}(2)(mu-pz)](ClO4)2 (Pd1), [{Pd(dach)Cl}(2)(mu-pz)](ClO4)(2) (Pd2), [{Pd(en)Cl}(2)(mu-pz)] (ClO4)(2) (Pd3), [{Pd(2,2-bipy)Cl}(2)(mu-4,4-bipy)](ClO4)(2) (Pd4), [{Pd(dach)Cl}(2)(mu-4,4-bipy)] (ClO4)(2) (Pd5) and [{Pd(en)Cl-2(mu-4,4-bipy)](ClO4)(2) (Pd6) (where 2,2-bipy = 2,2-bipyridyl, pz = pyrazine, dach = trans-(+/-)-1,2-diaminocyclohexane, en = ethylenediamine, 4,4-bipy = 4,4-bipyridyl) have been synthesized and characterized by elemental microanalysis, IR, H-1 NMR and MALDI-TOF mass spectrometry. The pK(a) values of corresponding diaqua complexes were determined by spectrophotometric pH titration. Substitution reactions with thiourea (Tu), L-methionine (L-Met), L-cysteine (L-Cys), L-histidine (L-His) and guanosine-5-monophosphate (5-GMP) were studied under the pseudo-first order conditions at pH 7.2. Reactions of Pdl with Tu, L-Met and L-Cys were followed by decomposition of complexes, while structures of dinuclear complexes were preserved during the substitution with nitrogen donors. Interactions with calf-thymus DNA (CT DNA) were followed by absorption spectroscopy and fluorescence quenching measurements. All complexes can bind to CT-DNA exhibiting high intrinsic binding constants (K-b = 10(4)-10(5) M-1). Competitive studies with ethidium bromide (EB) have shown that complexes can displace DNA-bound EB. High values of binding constants towards bovine serum albumin protein (BSA) indicate good binding affinity. Finally, all complexes showed moderate to high cytotoxic activity against HeLa (human cervical epithelial carcinoma cell lines) and MDA-MB-231 (human breast epithelial carcinoma cell lines) tumor cell lines inducing apoptotic type cell death, whereas normal fibroblasts were significantly less sensitive. The impact on cell cycle of these cells was distinctive, where Pd4, Pd5 and Pd6 showed the most prominent effect arresting MDA-MB-231 (human lung fibroblast cell lines) cell in G1/S phase of cell cycle.
T2  - Journal of Inorganic Biochemistry
T1  - New dinuclear palladium(II) complexes: Studies of the nucleophilic substitution reactions, DNA/BSA interactions and cytotoxic activity
VL  - 175
SP  - 67
EP  - 79
DO  - 10.1016/j.jinorgbio.2017.07.009
ER  - 
@article{
author = "Cocic, Dugan and Jovanović, Snežana and Nišavić, Marija and Baskic, Dejan and Todorović, Danijela V. and Popovic, Suzana and Bugarčić, Živadin D. and Petrović, Biljana",
year = "2017",
abstract = "Six new dinuclear Pd(II) complexes, [{Pd(2,2-bipy)Cl}(2)(mu-pz)](ClO4)2 (Pd1), [{Pd(dach)Cl}(2)(mu-pz)](ClO4)(2) (Pd2), [{Pd(en)Cl}(2)(mu-pz)] (ClO4)(2) (Pd3), [{Pd(2,2-bipy)Cl}(2)(mu-4,4-bipy)](ClO4)(2) (Pd4), [{Pd(dach)Cl}(2)(mu-4,4-bipy)] (ClO4)(2) (Pd5) and [{Pd(en)Cl-2(mu-4,4-bipy)](ClO4)(2) (Pd6) (where 2,2-bipy = 2,2-bipyridyl, pz = pyrazine, dach = trans-(+/-)-1,2-diaminocyclohexane, en = ethylenediamine, 4,4-bipy = 4,4-bipyridyl) have been synthesized and characterized by elemental microanalysis, IR, H-1 NMR and MALDI-TOF mass spectrometry. The pK(a) values of corresponding diaqua complexes were determined by spectrophotometric pH titration. Substitution reactions with thiourea (Tu), L-methionine (L-Met), L-cysteine (L-Cys), L-histidine (L-His) and guanosine-5-monophosphate (5-GMP) were studied under the pseudo-first order conditions at pH 7.2. Reactions of Pdl with Tu, L-Met and L-Cys were followed by decomposition of complexes, while structures of dinuclear complexes were preserved during the substitution with nitrogen donors. Interactions with calf-thymus DNA (CT DNA) were followed by absorption spectroscopy and fluorescence quenching measurements. All complexes can bind to CT-DNA exhibiting high intrinsic binding constants (K-b = 10(4)-10(5) M-1). Competitive studies with ethidium bromide (EB) have shown that complexes can displace DNA-bound EB. High values of binding constants towards bovine serum albumin protein (BSA) indicate good binding affinity. Finally, all complexes showed moderate to high cytotoxic activity against HeLa (human cervical epithelial carcinoma cell lines) and MDA-MB-231 (human breast epithelial carcinoma cell lines) tumor cell lines inducing apoptotic type cell death, whereas normal fibroblasts were significantly less sensitive. The impact on cell cycle of these cells was distinctive, where Pd4, Pd5 and Pd6 showed the most prominent effect arresting MDA-MB-231 (human lung fibroblast cell lines) cell in G1/S phase of cell cycle.",
journal = "Journal of Inorganic Biochemistry",
title = "New dinuclear palladium(II) complexes: Studies of the nucleophilic substitution reactions, DNA/BSA interactions and cytotoxic activity",
volume = "175",
pages = "67-79",
doi = "10.1016/j.jinorgbio.2017.07.009"
}
Cocic, D., Jovanović, S., Nišavić, M., Baskic, D., Todorović, D. V., Popovic, S., Bugarčić, Ž. D.,& Petrović, B.. (2017). New dinuclear palladium(II) complexes: Studies of the nucleophilic substitution reactions, DNA/BSA interactions and cytotoxic activity. in Journal of Inorganic Biochemistry, 175, 67-79.
https://doi.org/10.1016/j.jinorgbio.2017.07.009
Cocic D, Jovanović S, Nišavić M, Baskic D, Todorović DV, Popovic S, Bugarčić ŽD, Petrović B. New dinuclear palladium(II) complexes: Studies of the nucleophilic substitution reactions, DNA/BSA interactions and cytotoxic activity. in Journal of Inorganic Biochemistry. 2017;175:67-79.
doi:10.1016/j.jinorgbio.2017.07.009 .
Cocic, Dugan, Jovanović, Snežana, Nišavić, Marija, Baskic, Dejan, Todorović, Danijela V., Popovic, Suzana, Bugarčić, Živadin D., Petrović, Biljana, "New dinuclear palladium(II) complexes: Studies of the nucleophilic substitution reactions, DNA/BSA interactions and cytotoxic activity" in Journal of Inorganic Biochemistry, 175 (2017):67-79,
https://doi.org/10.1016/j.jinorgbio.2017.07.009 . .
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New bimetallic palladium(II) and platinum(II) complexes: studies of the nucleophilic substitution reactions, interactions with CT-DNA, bovine serum albumin and cytotoxic activity

Jovanović, Snežana; Obrencevic, Katarina; Bugarčić, Živadin D.; Popović, Iva A.; Žakula, Jelena; Petrović, Biljana

(2016)

TY  - JOUR
AU  - Jovanović, Snežana
AU  - Obrencevic, Katarina
AU  - Bugarčić, Živadin D.
AU  - Popović, Iva A.
AU  - Žakula, Jelena
AU  - Petrović, Biljana
PY  - 2016
UR  - http://vinar.vin.bg.ac.rs/handle/123456789/1208
AB  - Two new dinuclear bimetallic complexes, [{PdCl(bipy)}{mu-(pyrazine)}{PtCl(bipy)}]Cl(ClO4) (1) (bipy is 2,2-=bipyridine) and [{PdCl(en)}{mu-(pyrazine)}{PtCl(en)}]Cl(ClO4) (2) (en is ethylenediamine), have been synthesized and characterized by elemental microanalysis, IR, H-1 NMR spectroscopy and MALDI-TOF mass spectrometry. The pK(a) values of the coordinated water molecules of the diaqua species were determined as well. Substitution reactions of complexes (1) and (2) with thiourea (Tu), L-methionine (L-Met), L-cysteine (L-Cys), L-histidine (L-His) and guanosine-5-monophosphate (5-GMP) were studied under the pseudo-first order conditions as a function of nucleophile concentration and temperature. The order of reactivity of nucleophiles was: Tu GT L-Met GT L-Cys GT L-His GT 5-GMP. Substitution reactions with Tu, L-Cys and L-His were followed by decomposition of bimetallic complexes to the corresponding substituted mononuclear complexes [Pd(N-N)(Nu)(2)] and [Pt(N-N)(Nu)(2)] (N-N = bipy, en), releasing the bridging ligand. However, the structures of starting bimetallic complexes were preserved during the reactions with L-Met and 5-GMP. The absorption spectroscopic study of interactions of calf-thymus DNA (CT-DNA) with complexes (1), (2) and [{PdCl(bipy)}{mu-(NH2(CH2)(6)H2N)} {PtCl(bipy)}] Cl(ClO4) (3), has shown that all the complexes exhibit high intrinsic binding constants (K-b = 10(4)-10(5) M-1). DNA-ethidium bromide (DNA-EB) fluorescence was quenched after addition of complexes (1), (2) or (3), indicating displacement of intercalating EB by complexes. All complexes have shown good binding affinity to bovine serum albumin protein (BSA). Chemosensitivity of A375 (human melanoma) and HeLa (human cervical cancer) cell lines toward complexes (1), (2) and (3) was analyzed by SRB assay. Complex (1) displayed significant inhibitory effect on the growth of both cell lines.
T2  - Dalton Transactions
T1  - New bimetallic palladium(II) and platinum(II) complexes: studies of the nucleophilic substitution reactions, interactions with CT-DNA, bovine serum albumin and cytotoxic activity
VL  - 45
IS  - 31
SP  - 12444
EP  - 12457
DO  - 10.1039/c6dt02226j
ER  - 
@article{
author = "Jovanović, Snežana and Obrencevic, Katarina and Bugarčić, Živadin D. and Popović, Iva A. and Žakula, Jelena and Petrović, Biljana",
year = "2016",
abstract = "Two new dinuclear bimetallic complexes, [{PdCl(bipy)}{mu-(pyrazine)}{PtCl(bipy)}]Cl(ClO4) (1) (bipy is 2,2-=bipyridine) and [{PdCl(en)}{mu-(pyrazine)}{PtCl(en)}]Cl(ClO4) (2) (en is ethylenediamine), have been synthesized and characterized by elemental microanalysis, IR, H-1 NMR spectroscopy and MALDI-TOF mass spectrometry. The pK(a) values of the coordinated water molecules of the diaqua species were determined as well. Substitution reactions of complexes (1) and (2) with thiourea (Tu), L-methionine (L-Met), L-cysteine (L-Cys), L-histidine (L-His) and guanosine-5-monophosphate (5-GMP) were studied under the pseudo-first order conditions as a function of nucleophile concentration and temperature. The order of reactivity of nucleophiles was: Tu GT L-Met GT L-Cys GT L-His GT 5-GMP. Substitution reactions with Tu, L-Cys and L-His were followed by decomposition of bimetallic complexes to the corresponding substituted mononuclear complexes [Pd(N-N)(Nu)(2)] and [Pt(N-N)(Nu)(2)] (N-N = bipy, en), releasing the bridging ligand. However, the structures of starting bimetallic complexes were preserved during the reactions with L-Met and 5-GMP. The absorption spectroscopic study of interactions of calf-thymus DNA (CT-DNA) with complexes (1), (2) and [{PdCl(bipy)}{mu-(NH2(CH2)(6)H2N)} {PtCl(bipy)}] Cl(ClO4) (3), has shown that all the complexes exhibit high intrinsic binding constants (K-b = 10(4)-10(5) M-1). DNA-ethidium bromide (DNA-EB) fluorescence was quenched after addition of complexes (1), (2) or (3), indicating displacement of intercalating EB by complexes. All complexes have shown good binding affinity to bovine serum albumin protein (BSA). Chemosensitivity of A375 (human melanoma) and HeLa (human cervical cancer) cell lines toward complexes (1), (2) and (3) was analyzed by SRB assay. Complex (1) displayed significant inhibitory effect on the growth of both cell lines.",
journal = "Dalton Transactions",
title = "New bimetallic palladium(II) and platinum(II) complexes: studies of the nucleophilic substitution reactions, interactions with CT-DNA, bovine serum albumin and cytotoxic activity",
volume = "45",
number = "31",
pages = "12444-12457",
doi = "10.1039/c6dt02226j"
}
Jovanović, S., Obrencevic, K., Bugarčić, Ž. D., Popović, I. A., Žakula, J.,& Petrović, B.. (2016). New bimetallic palladium(II) and platinum(II) complexes: studies of the nucleophilic substitution reactions, interactions with CT-DNA, bovine serum albumin and cytotoxic activity. in Dalton Transactions, 45(31), 12444-12457.
https://doi.org/10.1039/c6dt02226j
Jovanović S, Obrencevic K, Bugarčić ŽD, Popović IA, Žakula J, Petrović B. New bimetallic palladium(II) and platinum(II) complexes: studies of the nucleophilic substitution reactions, interactions with CT-DNA, bovine serum albumin and cytotoxic activity. in Dalton Transactions. 2016;45(31):12444-12457.
doi:10.1039/c6dt02226j .
Jovanović, Snežana, Obrencevic, Katarina, Bugarčić, Živadin D., Popović, Iva A., Žakula, Jelena, Petrović, Biljana, "New bimetallic palladium(II) and platinum(II) complexes: studies of the nucleophilic substitution reactions, interactions with CT-DNA, bovine serum albumin and cytotoxic activity" in Dalton Transactions, 45, no. 31 (2016):12444-12457,
https://doi.org/10.1039/c6dt02226j . .
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Kinetics and mechanism of the substitution reactions of some monofunctional Pt(II) complexes with heterocyclic nitrogen donor molecules. Crystal structure of [Pt(bpma)(pzBr)]Cl-2 center dot 2H(2)O

Kosovic, Milica; Jovanović, Snežana; Bogdanović, Goran A.; Giester, Gerald; Jacimovic, Zeljko; Bugarčić, Živadin D.; Petrović, Biljana

(2016)

TY  - JOUR
AU  - Kosovic, Milica
AU  - Jovanović, Snežana
AU  - Bogdanović, Goran A.
AU  - Giester, Gerald
AU  - Jacimovic, Zeljko
AU  - Bugarčić, Živadin D.
AU  - Petrović, Biljana
PY  - 2016
UR  - http://vinar.vin.bg.ac.rs/handle/123456789/1253
AB  - Substitution reactions of [Pt(terpy)Cl](+) (terpy=2,2;6,2-terpyridine), [Pt(bpma)Cl](+) (bpma=bis(2-pyridylmethyl)amine), [Pt(dien)Cl](+) (dien=diethylenetriamine or 1,5-diamino-3-azapentane) and [Pt(tpdm)Cl](+) (tpdm=tripyridinedimethane) with nitrogen donor heterocyclic molecules, such as 3-amino-4-iodo-pyrazole (pzI), 5-amino-4-bromo-3-methyl-pyrazole (pzBr) and imidazole (Im), were studied in aqueous 0.10M NaClO4 in the presence of 10mM NaCl using variable-temperature UV-vis spectrophotometry. The second-order rate constants k(2) indicate decrease in reactivity in the order [Pt(terpy)Cl](+) GT [Pt(bpma)Cl](+) GT [Pt(tpdm)Cl](+) GT [Pt(dien)Cl](+). The most reactive nucleophile among the heterocyclic compounds is imidazole, while pzI shows slightly higher reactivity than pzBr. Activation parameters were also determined and the negative values for entropies of activation, S, support an associative mode of substitution for all substitution processes. Crystal structure of [Pt(bpma)(pzBr)]Cl(2)2H(2)O was determined by single-crystal X-ray analysis. The coordination geometry of the complex is distorted square-planar while the bond distance Pt-N2(pzBr) is longer than the other three Pt-N distances.
T2  - Journal of Coordination Chemistry
T1  - Kinetics and mechanism of the substitution reactions of some monofunctional Pt(II) complexes with heterocyclic nitrogen donor molecules. Crystal structure of [Pt(bpma)(pzBr)]Cl-2 center dot 2H(2)O
VL  - 69
IS  - 19
SP  - 2819
EP  - 2831
DO  - 10.1080/00958972.2016.1224336
ER  - 
@article{
author = "Kosovic, Milica and Jovanović, Snežana and Bogdanović, Goran A. and Giester, Gerald and Jacimovic, Zeljko and Bugarčić, Živadin D. and Petrović, Biljana",
year = "2016",
abstract = "Substitution reactions of [Pt(terpy)Cl](+) (terpy=2,2;6,2-terpyridine), [Pt(bpma)Cl](+) (bpma=bis(2-pyridylmethyl)amine), [Pt(dien)Cl](+) (dien=diethylenetriamine or 1,5-diamino-3-azapentane) and [Pt(tpdm)Cl](+) (tpdm=tripyridinedimethane) with nitrogen donor heterocyclic molecules, such as 3-amino-4-iodo-pyrazole (pzI), 5-amino-4-bromo-3-methyl-pyrazole (pzBr) and imidazole (Im), were studied in aqueous 0.10M NaClO4 in the presence of 10mM NaCl using variable-temperature UV-vis spectrophotometry. The second-order rate constants k(2) indicate decrease in reactivity in the order [Pt(terpy)Cl](+) GT [Pt(bpma)Cl](+) GT [Pt(tpdm)Cl](+) GT [Pt(dien)Cl](+). The most reactive nucleophile among the heterocyclic compounds is imidazole, while pzI shows slightly higher reactivity than pzBr. Activation parameters were also determined and the negative values for entropies of activation, S, support an associative mode of substitution for all substitution processes. Crystal structure of [Pt(bpma)(pzBr)]Cl(2)2H(2)O was determined by single-crystal X-ray analysis. The coordination geometry of the complex is distorted square-planar while the bond distance Pt-N2(pzBr) is longer than the other three Pt-N distances.",
journal = "Journal of Coordination Chemistry",
title = "Kinetics and mechanism of the substitution reactions of some monofunctional Pt(II) complexes with heterocyclic nitrogen donor molecules. Crystal structure of [Pt(bpma)(pzBr)]Cl-2 center dot 2H(2)O",
volume = "69",
number = "19",
pages = "2819-2831",
doi = "10.1080/00958972.2016.1224336"
}
Kosovic, M., Jovanović, S., Bogdanović, G. A., Giester, G., Jacimovic, Z., Bugarčić, Ž. D.,& Petrović, B.. (2016). Kinetics and mechanism of the substitution reactions of some monofunctional Pt(II) complexes with heterocyclic nitrogen donor molecules. Crystal structure of [Pt(bpma)(pzBr)]Cl-2 center dot 2H(2)O. in Journal of Coordination Chemistry, 69(19), 2819-2831.
https://doi.org/10.1080/00958972.2016.1224336
Kosovic M, Jovanović S, Bogdanović GA, Giester G, Jacimovic Z, Bugarčić ŽD, Petrović B. Kinetics and mechanism of the substitution reactions of some monofunctional Pt(II) complexes with heterocyclic nitrogen donor molecules. Crystal structure of [Pt(bpma)(pzBr)]Cl-2 center dot 2H(2)O. in Journal of Coordination Chemistry. 2016;69(19):2819-2831.
doi:10.1080/00958972.2016.1224336 .
Kosovic, Milica, Jovanović, Snežana, Bogdanović, Goran A., Giester, Gerald, Jacimovic, Zeljko, Bugarčić, Živadin D., Petrović, Biljana, "Kinetics and mechanism of the substitution reactions of some monofunctional Pt(II) complexes with heterocyclic nitrogen donor molecules. Crystal structure of [Pt(bpma)(pzBr)]Cl-2 center dot 2H(2)O" in Journal of Coordination Chemistry, 69, no. 19 (2016):2819-2831,
https://doi.org/10.1080/00958972.2016.1224336 . .
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Kinetics and mechanism of substitution reactions of the new bimetallic [{PdCl(bipy)}{mu-(NH2(CH2)(6)H2N)}{PtCl(biPY)}]Cl(ClO4) complex with important bio-molecules

Jovanović, Snežana; Petrović, Biljana; Petković, Marijana; Bugarčić, Živadin D.

(Elsevier, 2015)

TY  - JOUR
AU  - Jovanović, Snežana
AU  - Petrović, Biljana
AU  - Petković, Marijana
AU  - Bugarčić, Živadin D.
PY  - 2015
UR  - http://vinar.vin.bg.ac.rs/handle/123456789/841
AB  - The new dinuclear bimetallic complex, [{PdCl(bipy)}{mu-(NH2(CH2)(6)H2N)}{PtCl(biPY)}]Cl(ClO4) (bipy is 2,2-bipyridine), has been prepared and characterized by elemental microanalysis, IR, H-1 NMR spectroscopy and MALDI-TOF mass spectrometry. Substitution reactions of the studied complex with selected biologically important ligands such as: thiourea (Tu), L-methionine (L-Met), L-cysteine (L-Cys), L-histidine (L-His) and guanosine-5-monophosphate (5-GMP), were studied under the pseudo-first order conditions as a function of concentration and temperature using stopped-flow and UV-Vis spectrophotometry. The reactions were monitored in 0.1 M NaClO4 at pH 5.0, in the presence of 40 mM NaCI. All fast reactions were monitored by stopped-flow at three temperatures (288 K, 298 K, 308 K) to determine the activation parameters, while the reactions studied by UV-Vis spectrophotometry were tested only at 298 K. Observed order of reactivity of the used ligands is: Tu GT L-Met GT L-Cys GT L-His GT 5-GMP. Substitution reactions of the investigated bimetallic complex with Tu, L-Cys and L-His were followed by degradation to the corresponding substituted mononuclear complexes of palladium (II) and platinum (II), [Pd(bipy)(Nu)(2)] and [Pt(bipy)(Nu)(2)] (where Nu = Tu, L-Cys, L-His), by releasing of the bridge ligand,1,6-diaminohexane. In contrast, during the substitution reactions with L-Met and 5-GMP, the structure of starting bimetallic complex was preserved and the process of degradation can be halted. The proposed pathways of the substitution reactions of [{PdCl(bipy)}{mu-(NH2(CH2)(6)H2N)}{PtCl(biPY)}]Cl(ClO4) complex with all selected ligands were confirmed by H-1 NMR spectroscopy at 295 K. Additionally, the two pK(a) values of studied diaqua complex, [(Pd(H2O)(bipy)}(mu-(NH2(CH2)(6)H2N)}(Pt(H2O)(biPY)}](4+), were determined by spectrophotometric pH titration. The large negative values for the entropy of activation, Delta S-not equal, support an associative substitution mechanism. (C) 2015 Elsevier Ltd. All rights reserved.
PB  - Elsevier
T2  - Polyhedron
T1  - Kinetics and mechanism of substitution reactions of the new bimetallic [{PdCl(bipy)}{mu-(NH2(CH2)(6)H2N)}{PtCl(biPY)}]Cl(ClO4) complex with important bio-molecules
VL  - 101
SP  - 206
EP  - 214
DO  - 10.1016/j.poly.2015.09.021
ER  - 
@article{
author = "Jovanović, Snežana and Petrović, Biljana and Petković, Marijana and Bugarčić, Živadin D.",
year = "2015",
abstract = "The new dinuclear bimetallic complex, [{PdCl(bipy)}{mu-(NH2(CH2)(6)H2N)}{PtCl(biPY)}]Cl(ClO4) (bipy is 2,2-bipyridine), has been prepared and characterized by elemental microanalysis, IR, H-1 NMR spectroscopy and MALDI-TOF mass spectrometry. Substitution reactions of the studied complex with selected biologically important ligands such as: thiourea (Tu), L-methionine (L-Met), L-cysteine (L-Cys), L-histidine (L-His) and guanosine-5-monophosphate (5-GMP), were studied under the pseudo-first order conditions as a function of concentration and temperature using stopped-flow and UV-Vis spectrophotometry. The reactions were monitored in 0.1 M NaClO4 at pH 5.0, in the presence of 40 mM NaCI. All fast reactions were monitored by stopped-flow at three temperatures (288 K, 298 K, 308 K) to determine the activation parameters, while the reactions studied by UV-Vis spectrophotometry were tested only at 298 K. Observed order of reactivity of the used ligands is: Tu GT L-Met GT L-Cys GT L-His GT 5-GMP. Substitution reactions of the investigated bimetallic complex with Tu, L-Cys and L-His were followed by degradation to the corresponding substituted mononuclear complexes of palladium (II) and platinum (II), [Pd(bipy)(Nu)(2)] and [Pt(bipy)(Nu)(2)] (where Nu = Tu, L-Cys, L-His), by releasing of the bridge ligand,1,6-diaminohexane. In contrast, during the substitution reactions with L-Met and 5-GMP, the structure of starting bimetallic complex was preserved and the process of degradation can be halted. The proposed pathways of the substitution reactions of [{PdCl(bipy)}{mu-(NH2(CH2)(6)H2N)}{PtCl(biPY)}]Cl(ClO4) complex with all selected ligands were confirmed by H-1 NMR spectroscopy at 295 K. Additionally, the two pK(a) values of studied diaqua complex, [(Pd(H2O)(bipy)}(mu-(NH2(CH2)(6)H2N)}(Pt(H2O)(biPY)}](4+), were determined by spectrophotometric pH titration. The large negative values for the entropy of activation, Delta S-not equal, support an associative substitution mechanism. (C) 2015 Elsevier Ltd. All rights reserved.",
publisher = "Elsevier",
journal = "Polyhedron",
title = "Kinetics and mechanism of substitution reactions of the new bimetallic [{PdCl(bipy)}{mu-(NH2(CH2)(6)H2N)}{PtCl(biPY)}]Cl(ClO4) complex with important bio-molecules",
volume = "101",
pages = "206-214",
doi = "10.1016/j.poly.2015.09.021"
}
Jovanović, S., Petrović, B., Petković, M.,& Bugarčić, Ž. D.. (2015). Kinetics and mechanism of substitution reactions of the new bimetallic [{PdCl(bipy)}{mu-(NH2(CH2)(6)H2N)}{PtCl(biPY)}]Cl(ClO4) complex with important bio-molecules. in Polyhedron
Elsevier., 101, 206-214.
https://doi.org/10.1016/j.poly.2015.09.021
Jovanović S, Petrović B, Petković M, Bugarčić ŽD. Kinetics and mechanism of substitution reactions of the new bimetallic [{PdCl(bipy)}{mu-(NH2(CH2)(6)H2N)}{PtCl(biPY)}]Cl(ClO4) complex with important bio-molecules. in Polyhedron. 2015;101:206-214.
doi:10.1016/j.poly.2015.09.021 .
Jovanović, Snežana, Petrović, Biljana, Petković, Marijana, Bugarčić, Živadin D., "Kinetics and mechanism of substitution reactions of the new bimetallic [{PdCl(bipy)}{mu-(NH2(CH2)(6)H2N)}{PtCl(biPY)}]Cl(ClO4) complex with important bio-molecules" in Polyhedron, 101 (2015):206-214,
https://doi.org/10.1016/j.poly.2015.09.021 . .
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Interactions of nitrogen-donor bio-molecules with dinuclear platinum(II) complexes

Jovanović, Snežana; Bogojeski, Jovana V.; Petković, Marijana; Bugarčić, Živadin D.

(2015)

TY  - JOUR
AU  - Jovanović, Snežana
AU  - Bogojeski, Jovana V.
AU  - Petković, Marijana
AU  - Bugarčić, Živadin D.
PY  - 2015
UR  - http://vinar.vin.bg.ac.rs/handle/123456789/740
AB  - Substitution reactions of the dinuclear Pt(II) complexes, [{Pt(en) Cl}(2)(mu-pz)](2+) (1), [{Pt(dach)Cl}(2) (mu-pz)](2)+ (2) and [{Pt(dach)Cl}(2)(mu-4,4-bipy)](2+) (3), and corresponding aqua analogs with selected biologically important ligands, viz. 1,2,4-triazole, L-histidine (L-His) and guanosine-5-monophosphate (5-GMP) were studied under pseudo-first-order conditions as a function of concentration and temperature using UV-vis spectrophotometry. The reactions of the chloride complexes were followed in aqueous 25 mmol L-1 Hepes buffer in the presence of 40 mmol L-1 NaCl at pH 7.2, whereas the reactions of the aqua complexes were studied at pH 2.5. Two consecutive reaction steps, which both depend on the nucleophile concentration, were observed in all cases. The second-order rate constants for both reaction steps indicate a decrease in the order 1 GT 2 GT 3 for all complexes. Also, the pKa values of all three aqua complexes were determined. The order of the reactivity of the studied ligands is 1,2,4-triazole GT L-His GT 5-GMP. H-1 NMR spectroscopy and HPLC were used to follow the substitution of chloride in the dichloride 1, 2, and 3 complexes by guanosine-5-monophosphate (5-GMP). This study shows that the inert and bridging ligands have an important influence on the reactivity of the studied complexes.
T2  - Journal of Coordination Chemistry
T1  - Interactions of nitrogen-donor bio-molecules with dinuclear platinum(II) complexes
VL  - 68
IS  - 17-18
SP  - 3148
EP  - 3163
DO  - 10.1080/00958972.2015.1048240
ER  - 
@article{
author = "Jovanović, Snežana and Bogojeski, Jovana V. and Petković, Marijana and Bugarčić, Živadin D.",
year = "2015",
abstract = "Substitution reactions of the dinuclear Pt(II) complexes, [{Pt(en) Cl}(2)(mu-pz)](2+) (1), [{Pt(dach)Cl}(2) (mu-pz)](2)+ (2) and [{Pt(dach)Cl}(2)(mu-4,4-bipy)](2+) (3), and corresponding aqua analogs with selected biologically important ligands, viz. 1,2,4-triazole, L-histidine (L-His) and guanosine-5-monophosphate (5-GMP) were studied under pseudo-first-order conditions as a function of concentration and temperature using UV-vis spectrophotometry. The reactions of the chloride complexes were followed in aqueous 25 mmol L-1 Hepes buffer in the presence of 40 mmol L-1 NaCl at pH 7.2, whereas the reactions of the aqua complexes were studied at pH 2.5. Two consecutive reaction steps, which both depend on the nucleophile concentration, were observed in all cases. The second-order rate constants for both reaction steps indicate a decrease in the order 1 GT 2 GT 3 for all complexes. Also, the pKa values of all three aqua complexes were determined. The order of the reactivity of the studied ligands is 1,2,4-triazole GT L-His GT 5-GMP. H-1 NMR spectroscopy and HPLC were used to follow the substitution of chloride in the dichloride 1, 2, and 3 complexes by guanosine-5-monophosphate (5-GMP). This study shows that the inert and bridging ligands have an important influence on the reactivity of the studied complexes.",
journal = "Journal of Coordination Chemistry",
title = "Interactions of nitrogen-donor bio-molecules with dinuclear platinum(II) complexes",
volume = "68",
number = "17-18",
pages = "3148-3163",
doi = "10.1080/00958972.2015.1048240"
}
Jovanović, S., Bogojeski, J. V., Petković, M.,& Bugarčić, Ž. D.. (2015). Interactions of nitrogen-donor bio-molecules with dinuclear platinum(II) complexes. in Journal of Coordination Chemistry, 68(17-18), 3148-3163.
https://doi.org/10.1080/00958972.2015.1048240
Jovanović S, Bogojeski JV, Petković M, Bugarčić ŽD. Interactions of nitrogen-donor bio-molecules with dinuclear platinum(II) complexes. in Journal of Coordination Chemistry. 2015;68(17-18):3148-3163.
doi:10.1080/00958972.2015.1048240 .
Jovanović, Snežana, Bogojeski, Jovana V., Petković, Marijana, Bugarčić, Živadin D., "Interactions of nitrogen-donor bio-molecules with dinuclear platinum(II) complexes" in Journal of Coordination Chemistry, 68, no. 17-18 (2015):3148-3163,
https://doi.org/10.1080/00958972.2015.1048240 . .
6
8
9

Inhibitory effect of cisplatin and [Pt(dach)Cl2] on the activity of phospholipase A2

Radisavljevic, Maja; Kamceva, Tina; Bugarčić, Živadin D.; Petković, Marijana

(2013)

TY  - JOUR
AU  - Radisavljevic, Maja
AU  - Kamceva, Tina
AU  - Bugarčić, Živadin D.
AU  - Petković, Marijana
PY  - 2013
UR  - http://vinar.vin.bg.ac.rs/handle/123456789/5583
AB  - This work has been focused on testing the influence of two selected Pt(II) complexes cisplatin, Pt(NH3)(2) Cl-2, and [Pt(dach)Cl-2] on the activity of porcine pancreatic phospholipase A(2) (PLA(2)). It has been assumed that this enzyme plays a role in carcinogenesis and that it could be a target in the tumour therapy. The results of this study show that both Pt(II) complexes inhibit the activity of the enzyme, though they bind to it in a different manner. While cisplatin interacts with the enzyme in an acompetitive manner, the stable interaction of [Pt(dach)Cl-2] with PLA(2) could not be detected under our experimental conditions.
T2  - Journal of Enzyme Inhibition and Medicinal Chemistry
T1  - Inhibitory effect of cisplatin and [Pt(dach)Cl2] on the activity of phospholipase A2
VL  - 28
IS  - 4
SP  - 651
EP  - 660
DO  - 10.3109/14756366.2012.666539
ER  - 
@article{
author = "Radisavljevic, Maja and Kamceva, Tina and Bugarčić, Živadin D. and Petković, Marijana",
year = "2013",
abstract = "This work has been focused on testing the influence of two selected Pt(II) complexes cisplatin, Pt(NH3)(2) Cl-2, and [Pt(dach)Cl-2] on the activity of porcine pancreatic phospholipase A(2) (PLA(2)). It has been assumed that this enzyme plays a role in carcinogenesis and that it could be a target in the tumour therapy. The results of this study show that both Pt(II) complexes inhibit the activity of the enzyme, though they bind to it in a different manner. While cisplatin interacts with the enzyme in an acompetitive manner, the stable interaction of [Pt(dach)Cl-2] with PLA(2) could not be detected under our experimental conditions.",
journal = "Journal of Enzyme Inhibition and Medicinal Chemistry",
title = "Inhibitory effect of cisplatin and [Pt(dach)Cl2] on the activity of phospholipase A2",
volume = "28",
number = "4",
pages = "651-660",
doi = "10.3109/14756366.2012.666539"
}
Radisavljevic, M., Kamceva, T., Bugarčić, Ž. D.,& Petković, M.. (2013). Inhibitory effect of cisplatin and [Pt(dach)Cl2] on the activity of phospholipase A2. in Journal of Enzyme Inhibition and Medicinal Chemistry, 28(4), 651-660.
https://doi.org/10.3109/14756366.2012.666539
Radisavljevic M, Kamceva T, Bugarčić ŽD, Petković M. Inhibitory effect of cisplatin and [Pt(dach)Cl2] on the activity of phospholipase A2. in Journal of Enzyme Inhibition and Medicinal Chemistry. 2013;28(4):651-660.
doi:10.3109/14756366.2012.666539 .
Radisavljevic, Maja, Kamceva, Tina, Bugarčić, Živadin D., Petković, Marijana, "Inhibitory effect of cisplatin and [Pt(dach)Cl2] on the activity of phospholipase A2" in Journal of Enzyme Inhibition and Medicinal Chemistry, 28, no. 4 (2013):651-660,
https://doi.org/10.3109/14756366.2012.666539 . .
1
2
1
1

Laser desorption and ionization time-of-flight versus matrix-assisted laser desorption and ionization time-of-flight mass spectrometry of Pt(II) and Ru(III) metal complexes

Damnjanović, Bojana; Kamceva, Tina; Petrović, Biljana; Bugarčić, Živadin D.; Petković, Marijana

(2011)

TY  - JOUR
AU  - Damnjanović, Bojana
AU  - Kamceva, Tina
AU  - Petrović, Biljana
AU  - Bugarčić, Živadin D.
AU  - Petković, Marijana
PY  - 2011
UR  - http://vinar.vin.bg.ac.rs/handle/123456789/4237
AB  - Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) has been recently established as a powerful, soft ionization technique for the analysis of both transition metal complexes, which are used as metallo-drugs in the therapy of various types of tumors, and biomolecules. Since some metal complexes absorb light in the UV range, it should be possible to analyse them without additional matrices, i.e. using LDI-TOF MS. In this study, the matrix-free approach was tested for the analysis of [PtCl(2)(dach)] (dichloride(1,2-diamincyclohexane) platinum(II)), [RuCl(2)(en)(2)]Cl (dichloridobis(ethylenediamine) ruthenium(III) chloride) and [RuCl(2)(bipy)(2)]Cl (bis(bipyridine)dichloridoruthenium(III) chloride) and the detection limit for these compounds was determined. In summary, the LDI-TOF mass spectra of [PtCl(2)(dach)] and [RuCl(2)(en)(2)]Cl are rather simple, whereas in the presence of 2,5-DHB as a matrix, additional peaks are generated. On the other hand, the standard MALDI-TOF mass spectrum of [RuCl(2)(bipy)(2)]Cl exhibits only one peak arising from the complex, in contrast to six peaks detectable in the LDI-TOF mass spectrum. The detection limit in the MALDI-TOF MS analysis of [PtCl(2)(dach)] and [RuCl(2)(bipy)(2)]Cl complexes was lower than that determined in LDI-TOF MS. Taking all into account, in this paper, we have demonstrated some advantages and drawbacks of the matrix-free LDI-TOF mass spectrometric analysis of transition metal complexes.
T2  - Analytical Methods
T1  - Laser desorption and ionization time-of-flight versus matrix-assisted laser desorption and ionization time-of-flight mass spectrometry of Pt(II) and Ru(III) metal complexes
VL  - 3
IS  - 2
SP  - 400
EP  - 407
DO  - 10.1039/c0ay00517g
ER  - 
@article{
author = "Damnjanović, Bojana and Kamceva, Tina and Petrović, Biljana and Bugarčić, Živadin D. and Petković, Marijana",
year = "2011",
abstract = "Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) has been recently established as a powerful, soft ionization technique for the analysis of both transition metal complexes, which are used as metallo-drugs in the therapy of various types of tumors, and biomolecules. Since some metal complexes absorb light in the UV range, it should be possible to analyse them without additional matrices, i.e. using LDI-TOF MS. In this study, the matrix-free approach was tested for the analysis of [PtCl(2)(dach)] (dichloride(1,2-diamincyclohexane) platinum(II)), [RuCl(2)(en)(2)]Cl (dichloridobis(ethylenediamine) ruthenium(III) chloride) and [RuCl(2)(bipy)(2)]Cl (bis(bipyridine)dichloridoruthenium(III) chloride) and the detection limit for these compounds was determined. In summary, the LDI-TOF mass spectra of [PtCl(2)(dach)] and [RuCl(2)(en)(2)]Cl are rather simple, whereas in the presence of 2,5-DHB as a matrix, additional peaks are generated. On the other hand, the standard MALDI-TOF mass spectrum of [RuCl(2)(bipy)(2)]Cl exhibits only one peak arising from the complex, in contrast to six peaks detectable in the LDI-TOF mass spectrum. The detection limit in the MALDI-TOF MS analysis of [PtCl(2)(dach)] and [RuCl(2)(bipy)(2)]Cl complexes was lower than that determined in LDI-TOF MS. Taking all into account, in this paper, we have demonstrated some advantages and drawbacks of the matrix-free LDI-TOF mass spectrometric analysis of transition metal complexes.",
journal = "Analytical Methods",
title = "Laser desorption and ionization time-of-flight versus matrix-assisted laser desorption and ionization time-of-flight mass spectrometry of Pt(II) and Ru(III) metal complexes",
volume = "3",
number = "2",
pages = "400-407",
doi = "10.1039/c0ay00517g"
}
Damnjanović, B., Kamceva, T., Petrović, B., Bugarčić, Ž. D.,& Petković, M.. (2011). Laser desorption and ionization time-of-flight versus matrix-assisted laser desorption and ionization time-of-flight mass spectrometry of Pt(II) and Ru(III) metal complexes. in Analytical Methods, 3(2), 400-407.
https://doi.org/10.1039/c0ay00517g
Damnjanović B, Kamceva T, Petrović B, Bugarčić ŽD, Petković M. Laser desorption and ionization time-of-flight versus matrix-assisted laser desorption and ionization time-of-flight mass spectrometry of Pt(II) and Ru(III) metal complexes. in Analytical Methods. 2011;3(2):400-407.
doi:10.1039/c0ay00517g .
Damnjanović, Bojana, Kamceva, Tina, Petrović, Biljana, Bugarčić, Živadin D., Petković, Marijana, "Laser desorption and ionization time-of-flight versus matrix-assisted laser desorption and ionization time-of-flight mass spectrometry of Pt(II) and Ru(III) metal complexes" in Analytical Methods, 3, no. 2 (2011):400-407,
https://doi.org/10.1039/c0ay00517g . .
12
13
12

Flavonoids as matrices for MALDI-TOF mass spectrometric analysis of transition metal complexes

Petković, Marijana; Petrović, Biljana; Savić, Jasmina; Bugarčić, Živadin D.; Dimitrić-Marković, Jasmina; Momić, Tatjana; Vasić, Vesna M.

(2010)

TY  - JOUR
AU  - Petković, Marijana
AU  - Petrović, Biljana
AU  - Savić, Jasmina
AU  - Bugarčić, Živadin D.
AU  - Dimitrić-Marković, Jasmina
AU  - Momić, Tatjana
AU  - Vasić, Vesna M.
PY  - 2010
UR  - http://vinar.vin.bg.ac.rs/handle/123456789/3909
AB  - Matrix-assisted laser desorption and ionization time-of-flight mass spectrometry (MALDI-TOF MS) is a suitable method for the analysis of inorganic and organic compounds and biomolecules This makes. MALDI-TOF MS convenient for monitoring the interaction of metallo-drugs with biomolecules. Results presented in this manuscript demonstrate that flavonoids such as apigenin, kaempferol and luteolin are suitable for MALDI-TOF MS analysis of Pt(II), Pd(II), Pt(IV) and Ru(III) complexes, giving different signal-to-noise ratios of the analyte peak. The MALDI-TOF mass spectra of inorganic complexes acquired with these flavonoid matrices are easy to interpret and have some advantages over the application of other commonly used matrices: a low number of matrix peaks are detectable and the coordinative metal-ligand bond is, in most cases, preserved. On the other hand, flavonoids do not act as typical matrices, as their excess is not required for the acquisition of MALDI-TOF mass spectra of inorganic complexes. (C) 2009 Elsevier B.V. All rights reserved.
T2  - International Journal of Mass Spectrometry
T1  - Flavonoids as matrices for MALDI-TOF mass spectrometric analysis of transition metal complexes
VL  - 290
IS  - 1
SP  - 39
EP  - 46
DO  - 10.1016/j.ijms.2009.12.001
ER  - 
@article{
author = "Petković, Marijana and Petrović, Biljana and Savić, Jasmina and Bugarčić, Živadin D. and Dimitrić-Marković, Jasmina and Momić, Tatjana and Vasić, Vesna M.",
year = "2010",
abstract = "Matrix-assisted laser desorption and ionization time-of-flight mass spectrometry (MALDI-TOF MS) is a suitable method for the analysis of inorganic and organic compounds and biomolecules This makes. MALDI-TOF MS convenient for monitoring the interaction of metallo-drugs with biomolecules. Results presented in this manuscript demonstrate that flavonoids such as apigenin, kaempferol and luteolin are suitable for MALDI-TOF MS analysis of Pt(II), Pd(II), Pt(IV) and Ru(III) complexes, giving different signal-to-noise ratios of the analyte peak. The MALDI-TOF mass spectra of inorganic complexes acquired with these flavonoid matrices are easy to interpret and have some advantages over the application of other commonly used matrices: a low number of matrix peaks are detectable and the coordinative metal-ligand bond is, in most cases, preserved. On the other hand, flavonoids do not act as typical matrices, as their excess is not required for the acquisition of MALDI-TOF mass spectra of inorganic complexes. (C) 2009 Elsevier B.V. All rights reserved.",
journal = "International Journal of Mass Spectrometry",
title = "Flavonoids as matrices for MALDI-TOF mass spectrometric analysis of transition metal complexes",
volume = "290",
number = "1",
pages = "39-46",
doi = "10.1016/j.ijms.2009.12.001"
}
Petković, M., Petrović, B., Savić, J., Bugarčić, Ž. D., Dimitrić-Marković, J., Momić, T.,& Vasić, V. M.. (2010). Flavonoids as matrices for MALDI-TOF mass spectrometric analysis of transition metal complexes. in International Journal of Mass Spectrometry, 290(1), 39-46.
https://doi.org/10.1016/j.ijms.2009.12.001
Petković M, Petrović B, Savić J, Bugarčić ŽD, Dimitrić-Marković J, Momić T, Vasić VM. Flavonoids as matrices for MALDI-TOF mass spectrometric analysis of transition metal complexes. in International Journal of Mass Spectrometry. 2010;290(1):39-46.
doi:10.1016/j.ijms.2009.12.001 .
Petković, Marijana, Petrović, Biljana, Savić, Jasmina, Bugarčić, Živadin D., Dimitrić-Marković, Jasmina, Momić, Tatjana, Vasić, Vesna M., "Flavonoids as matrices for MALDI-TOF mass spectrometric analysis of transition metal complexes" in International Journal of Mass Spectrometry, 290, no. 1 (2010):39-46,
https://doi.org/10.1016/j.ijms.2009.12.001 . .
18
22
21

Matrix-assisted laser desorption and ionisation time-of-flight mass spectrometry of Pt(II) and Pd(II) complexes

Vujačić, Ana V.; Bugarčić, Živadin D.; Schiller, Jürgen; Vasić, Vesna M.; Petković, Marijana

(2009)

TY  - JOUR
AU  - Vujačić, Ana V.
AU  - Bugarčić, Živadin D.
AU  - Schiller, Jürgen
AU  - Vasić, Vesna M.
AU  - Petković, Marijana
PY  - 2009
UR  - http://vinar.vin.bg.ac.rs/handle/123456789/3816
AB  - In this work, we have analysed matrix-assisted laser desorption and ionisation time-of-flight (MALDI-TOF) mass spectra of [PtCl(2)(en)], [PtCl(2)(dach)] and [PdCl(dien)]Cl acquired either with 2,5-dihydroxybenzoic acid (DHB) or alpha-cyano-hydroxycinnamic acid (CHCA) as matrices. For certain experiments, small amounts of trifluoro, acetic acid (TFA) or higher concentration of inorganic salts (NaCl or KCl) was added to the matrix solution. The majority of peaks arising from the Pt(II) and Pd(II) complexes could be identified, but certain ions detectable in the spectra were generated upon ligand loss. Additionally. the analysis of Pt(II) complexes was also possible in the presence of a higher salt content, which is a commonly used analysis condition for the samples of biological origin. While DHB appears to be the best suited for MALDI-TOF mass spectrometric analysis of Pt(II) complexes, CHCA seems to be a better matrix for Pd(II) complex used in this study. On the other hand, small amounts of TFA improve the spectra quality of Pt(II) complexes. but lead most probably to the degradation of Pd(II) complex. Taken together, we have demonstrated that the analysis of metallo-drugs using MALDI-TOF MS, though accompanied with certain identification problems, is easy and reliable. On the other hand, having in mind that some complexes (i.e. a combination of a particular transition metal/ligand) cannot be analysed under conditions usually applied for others, we deem it necessary to find out the best conditions for MALDI-TOF MS analysis of each metal complex. (C) 2009 Elsevier Ltd. All rights reserved.
T2  - Polyhedron
T1  - Matrix-assisted laser desorption and ionisation time-of-flight mass spectrometry of Pt(II) and Pd(II) complexes
VL  - 28
IS  - 14
SP  - 2905
EP  - 2912
DO  - 10.1016/j.poly.2009.06.055
ER  - 
@article{
author = "Vujačić, Ana V. and Bugarčić, Živadin D. and Schiller, Jürgen and Vasić, Vesna M. and Petković, Marijana",
year = "2009",
abstract = "In this work, we have analysed matrix-assisted laser desorption and ionisation time-of-flight (MALDI-TOF) mass spectra of [PtCl(2)(en)], [PtCl(2)(dach)] and [PdCl(dien)]Cl acquired either with 2,5-dihydroxybenzoic acid (DHB) or alpha-cyano-hydroxycinnamic acid (CHCA) as matrices. For certain experiments, small amounts of trifluoro, acetic acid (TFA) or higher concentration of inorganic salts (NaCl or KCl) was added to the matrix solution. The majority of peaks arising from the Pt(II) and Pd(II) complexes could be identified, but certain ions detectable in the spectra were generated upon ligand loss. Additionally. the analysis of Pt(II) complexes was also possible in the presence of a higher salt content, which is a commonly used analysis condition for the samples of biological origin. While DHB appears to be the best suited for MALDI-TOF mass spectrometric analysis of Pt(II) complexes, CHCA seems to be a better matrix for Pd(II) complex used in this study. On the other hand, small amounts of TFA improve the spectra quality of Pt(II) complexes. but lead most probably to the degradation of Pd(II) complex. Taken together, we have demonstrated that the analysis of metallo-drugs using MALDI-TOF MS, though accompanied with certain identification problems, is easy and reliable. On the other hand, having in mind that some complexes (i.e. a combination of a particular transition metal/ligand) cannot be analysed under conditions usually applied for others, we deem it necessary to find out the best conditions for MALDI-TOF MS analysis of each metal complex. (C) 2009 Elsevier Ltd. All rights reserved.",
journal = "Polyhedron",
title = "Matrix-assisted laser desorption and ionisation time-of-flight mass spectrometry of Pt(II) and Pd(II) complexes",
volume = "28",
number = "14",
pages = "2905-2912",
doi = "10.1016/j.poly.2009.06.055"
}
Vujačić, A. V., Bugarčić, Ž. D., Schiller, J., Vasić, V. M.,& Petković, M.. (2009). Matrix-assisted laser desorption and ionisation time-of-flight mass spectrometry of Pt(II) and Pd(II) complexes. in Polyhedron, 28(14), 2905-2912.
https://doi.org/10.1016/j.poly.2009.06.055
Vujačić AV, Bugarčić ŽD, Schiller J, Vasić VM, Petković M. Matrix-assisted laser desorption and ionisation time-of-flight mass spectrometry of Pt(II) and Pd(II) complexes. in Polyhedron. 2009;28(14):2905-2912.
doi:10.1016/j.poly.2009.06.055 .
Vujačić, Ana V., Bugarčić, Živadin D., Schiller, Jürgen, Vasić, Vesna M., Petković, Marijana, "Matrix-assisted laser desorption and ionisation time-of-flight mass spectrometry of Pt(II) and Pd(II) complexes" in Polyhedron, 28, no. 14 (2009):2905-2912,
https://doi.org/10.1016/j.poly.2009.06.055 . .
10
10
9

Effects of micelles on the complex formation of [PtCl(dien)](+) with biologically relevant ligands

Soldatovic, Tanja; Vasić, Vesna M.; Bugarčić, Živadin D.

(2006)

TY  - JOUR
AU  - Soldatovic, Tanja
AU  - Vasić, Vesna M.
AU  - Bugarčić, Živadin D.
PY  - 2006
UR  - http://vinar.vin.bg.ac.rs/handle/123456789/3153
AB  - Substitution reactions of [PtCl(dien)](+) (dien = diethylenetriamine) with some biologically relevant ligands, such as L-methionine ((L)-Met), glutathione (GSH), and guanosine 5-nionophosphate (5-GMP), were studied in aqueous 0.10, 0.05, and 0.01 M NaClO4 Solutions at pH 2.5 using UV-vis spectrophotometry. The kinetics and mechanism of the complex-formation reactions were Studied as I function of nucleophile concentration and temperature. These reactions were also Studied in the presence and absence of micelles of sodium dodecyl sulfate (SIDS). The presence of anionic micelles accelerated complex-forination. The largest effect of micelles has been observed in the case of L-methionine. On the other hand, all increase in the ionic strength in the presence of micelles caused a decrease in the rate. The negative entropies of activation support all associative complex-formation mechanism.
T2  - Bulletin of the Chemical Society of Japan
T1  - Effects of micelles on the complex formation of [PtCl(dien)](+) with biologically relevant ligands
VL  - 79
IS  - 12
SP  - 1889
EP  - 1893
DO  - 10.1246/bcsj.79.1889
ER  - 
@article{
author = "Soldatovic, Tanja and Vasić, Vesna M. and Bugarčić, Živadin D.",
year = "2006",
abstract = "Substitution reactions of [PtCl(dien)](+) (dien = diethylenetriamine) with some biologically relevant ligands, such as L-methionine ((L)-Met), glutathione (GSH), and guanosine 5-nionophosphate (5-GMP), were studied in aqueous 0.10, 0.05, and 0.01 M NaClO4 Solutions at pH 2.5 using UV-vis spectrophotometry. The kinetics and mechanism of the complex-formation reactions were Studied as I function of nucleophile concentration and temperature. These reactions were also Studied in the presence and absence of micelles of sodium dodecyl sulfate (SIDS). The presence of anionic micelles accelerated complex-forination. The largest effect of micelles has been observed in the case of L-methionine. On the other hand, all increase in the ionic strength in the presence of micelles caused a decrease in the rate. The negative entropies of activation support all associative complex-formation mechanism.",
journal = "Bulletin of the Chemical Society of Japan",
title = "Effects of micelles on the complex formation of [PtCl(dien)](+) with biologically relevant ligands",
volume = "79",
number = "12",
pages = "1889-1893",
doi = "10.1246/bcsj.79.1889"
}
Soldatovic, T., Vasić, V. M.,& Bugarčić, Ž. D.. (2006). Effects of micelles on the complex formation of [PtCl(dien)](+) with biologically relevant ligands. in Bulletin of the Chemical Society of Japan, 79(12), 1889-1893.
https://doi.org/10.1246/bcsj.79.1889
Soldatovic T, Vasić VM, Bugarčić ŽD. Effects of micelles on the complex formation of [PtCl(dien)](+) with biologically relevant ligands. in Bulletin of the Chemical Society of Japan. 2006;79(12):1889-1893.
doi:10.1246/bcsj.79.1889 .
Soldatovic, Tanja, Vasić, Vesna M., Bugarčić, Živadin D., "Effects of micelles on the complex formation of [PtCl(dien)](+) with biologically relevant ligands" in Bulletin of the Chemical Society of Japan, 79, no. 12 (2006):1889-1893,
https://doi.org/10.1246/bcsj.79.1889 . .
3
4
4