TY  - JOUR
AU  - Jovanović, Dunja
AU  - Filipović, Ana
AU  - Janjić, Goran
AU  - Lazarević-Pašti, Tamara
AU  - Džambaski, Zdravko
AU  - Bondžić, Bojan
AU  - Bondžić, Aleksandra
PY  - 2024
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/12450
AB  - We have synthesized 22 C-1 functionalized-N-aryl-1,2,3,4-tetrahydroisoquinoline derivatives showing biological activities towards cholinergic enzymes. Synthesis was performed using visible-light-promoted photo-redox chemistry, starting from a common intermediate, and the application of this synthetic methodology drastically simplified synthetic routes and purification of desired compounds. All synthesized derivates were divided into four groups based on the substituents in the C-1 position, and their inhibition potencies towards two cholinergic enzymes, acetyl- and butyrylcholinesterase were evaluated. Most potent derivatives were selected, and kinetic analysis was further carried out to obtain insights into the mechanisms of inhibition of these two enzymes. Further validation of the mode of inhibition of cholinergic enzymes by the two most potent THIQ compounds, 3c and 3i, was performed using fluorescence-quenching titration studies. Molecular docking studies further confirmed the proposed mechanism of enzymes’ inhibition. In silico predictions of physicochemical properties, pharmacokinetics, drug-likeness, and medicinal chemistry friendliness of the selected most potent derivatives were performed using Swiss ADME tool. This was followed by UPLC-assisted log P determination and in vitro BBB permeability studies performed in order to assess the potential of the synthesized compounds to pass the BBB.
T2  - International Journal of Molecular Sciences
T1  - Targeting Alzheimer’s Disease: Evaluating the Efficacy of C-1 Functionalized N-Aryl-Tetrahydroisoquinolines as Cholinergic Enzyme Inhibitors and Promising Therapeutic Candidates
VL  - 25
IS  - 2
SP  - 1033
DO  - 10.3390/ijms25021033
ER  - 

@article{
author = "Jovanović, Dunja and Filipović, Ana and Janjić, Goran and Lazarević-Pašti, Tamara and Džambaski, Zdravko and Bondžić, Bojan and Bondžić, Aleksandra",
year = "2024",
abstract = "We have synthesized 22 C-1 functionalized-N-aryl-1,2,3,4-tetrahydroisoquinoline derivatives showing biological activities towards cholinergic enzymes. Synthesis was performed using visible-light-promoted photo-redox chemistry, starting from a common intermediate, and the application of this synthetic methodology drastically simplified synthetic routes and purification of desired compounds. All synthesized derivates were divided into four groups based on the substituents in the C-1 position, and their inhibition potencies towards two cholinergic enzymes, acetyl- and butyrylcholinesterase were evaluated. Most potent derivatives were selected, and kinetic analysis was further carried out to obtain insights into the mechanisms of inhibition of these two enzymes. Further validation of the mode of inhibition of cholinergic enzymes by the two most potent THIQ compounds, 3c and 3i, was performed using fluorescence-quenching titration studies. Molecular docking studies further confirmed the proposed mechanism of enzymes’ inhibition. In silico predictions of physicochemical properties, pharmacokinetics, drug-likeness, and medicinal chemistry friendliness of the selected most potent derivatives were performed using Swiss ADME tool. This was followed by UPLC-assisted log P determination and in vitro BBB permeability studies performed in order to assess the potential of the synthesized compounds to pass the BBB.",
journal = "International Journal of Molecular Sciences",
title = "Targeting Alzheimer’s Disease: Evaluating the Efficacy of C-1 Functionalized N-Aryl-Tetrahydroisoquinolines as Cholinergic Enzyme Inhibitors and Promising Therapeutic Candidates",
volume = "25",
number = "2",
pages = "1033",
doi = "10.3390/ijms25021033"
}

Jovanović, D., Filipović, A., Janjić, G., Lazarević-Pašti, T., Džambaski, Z., Bondžić, B.,& Bondžić, A.. (2024). Targeting Alzheimer’s Disease: Evaluating the Efficacy of C-1 Functionalized N-Aryl-Tetrahydroisoquinolines as Cholinergic Enzyme Inhibitors and Promising Therapeutic Candidates. in International Journal of Molecular Sciences, 25(2), 1033.
https://doi.org/10.3390/ijms25021033

Jovanović D, Filipović A, Janjić G, Lazarević-Pašti T, Džambaski Z, Bondžić B, Bondžić A. Targeting Alzheimer’s Disease: Evaluating the Efficacy of C-1 Functionalized N-Aryl-Tetrahydroisoquinolines as Cholinergic Enzyme Inhibitors and Promising Therapeutic Candidates. in International Journal of Molecular Sciences. 2024;25(2):1033.
doi:10.3390/ijms25021033 .

Jovanović, Dunja, Filipović, Ana, Janjić, Goran, Lazarević-Pašti, Tamara, Džambaski, Zdravko, Bondžić, Bojan, Bondžić, Aleksandra, "Targeting Alzheimer’s Disease: Evaluating the Efficacy of C-1 Functionalized N-Aryl-Tetrahydroisoquinolines as Cholinergic Enzyme Inhibitors and Promising Therapeutic Candidates" in International Journal of Molecular Sciences, 25, no. 2 (2024):1033,
https://doi.org/10.3390/ijms25021033 . .

TY  - CONF
AU  - Jovanović, Dunja
AU  - Kovačević, Marija
AU  - Živković, Sanja
AU  - Vasić Anićijević,  Dragana
PY  - 2023
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/12332
AB  - The rapid development of the materials science implies a need for efficient, practical and
economical screening methods to predict and tailor required material properties. Ab
initio screening of calculable target material properties has emerged in the last decade
with the development of computational speed, particularly in the field of electrocatalysis
[1], photochemistry, and adsorption [2]. Calculation of adhesion energies of metals is a
common approach in investigation of the stability of metallic overlayers on various
supports. In this contribution, we present a screening of adhesion energies of several
transition metals on high-symmetry sites of rutile TiO2(001) surface model, using spinrestricted DFT – GGA calculations, with ultrasoft pseudopotentials in a plane-wave
basis set (Figure 1).
According to the general trends obtained, adsorption energy decreases from 8th to 10th
group in periode, and also decreases in group with the increase of atomic number. To
confirm these prepositions and get more precise results, spin-polarized calculations
should be performed instead of spin-restricted.
PB  - Belgrade : Serbian Chemical Society and Serbian Young Chemists' Club
C3  - 9th Conference of Young Chemists of Serbia : Book of abstracts
T1  - DFT screening of the adhesion affinity of transition metals on TiO2 (001) surface
UR  - https://hdl.handle.net/21.15107/rcub_vinar_12332
ER  - 

@conference{
author = "Jovanović, Dunja and Kovačević, Marija and Živković, Sanja and Vasić Anićijević,  Dragana",
year = "2023",
abstract = "The rapid development of the materials science implies a need for efficient, practical and
economical screening methods to predict and tailor required material properties. Ab
initio screening of calculable target material properties has emerged in the last decade
with the development of computational speed, particularly in the field of electrocatalysis
[1], photochemistry, and adsorption [2]. Calculation of adhesion energies of metals is a
common approach in investigation of the stability of metallic overlayers on various
supports. In this contribution, we present a screening of adhesion energies of several
transition metals on high-symmetry sites of rutile TiO2(001) surface model, using spinrestricted DFT – GGA calculations, with ultrasoft pseudopotentials in a plane-wave
basis set (Figure 1).
According to the general trends obtained, adsorption energy decreases from 8th to 10th
group in periode, and also decreases in group with the increase of atomic number. To
confirm these prepositions and get more precise results, spin-polarized calculations
should be performed instead of spin-restricted.",
publisher = "Belgrade : Serbian Chemical Society and Serbian Young Chemists' Club",
journal = "9th Conference of Young Chemists of Serbia : Book of abstracts",
title = "DFT screening of the adhesion affinity of transition metals on TiO2 (001) surface",
url = "https://hdl.handle.net/21.15107/rcub_vinar_12332"
}

Jovanović, D., Kovačević, M., Živković, S.,& Vasić Anićijević, D.. (2023). DFT screening of the adhesion affinity of transition metals on TiO2 (001) surface. in 9th Conference of Young Chemists of Serbia : Book of abstracts
Belgrade : Serbian Chemical Society and Serbian Young Chemists' Club..
https://hdl.handle.net/21.15107/rcub_vinar_12332

Jovanović D, Kovačević M, Živković S, Vasić Anićijević D. DFT screening of the adhesion affinity of transition metals on TiO2 (001) surface. in 9th Conference of Young Chemists of Serbia : Book of abstracts. 2023;.
https://hdl.handle.net/21.15107/rcub_vinar_12332 .

Jovanović, Dunja, Kovačević, Marija, Živković, Sanja, Vasić Anićijević,  Dragana, "DFT screening of the adhesion affinity of transition metals on TiO2 (001) surface" in 9th Conference of Young Chemists of Serbia : Book of abstracts (2023),
https://hdl.handle.net/21.15107/rcub_vinar_12332 .

TY  - CONF
AU  - Jovanović, Dunja
AU  - Filipović, Ana
AU  - Bondžić, Bojan
AU  - Bondžić, Aleksandra
PY  - 2023
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/12228
AB  - Alzheimer's disease (AD), the most common form of dementia, is a progressive neurological disorder characterized by losing memory and other intellectual abilities that are serious enough to interfere with daily life. The disease is associated with loss of cholinergic neurons in the brain and the decreased level of ACh. In order to raise the ACh level in the brain the acetylcholinesterase (AChE) inhibitors have been applied as relevant drugs in the AD therapy. On the other hand, these inhibitors treat and improve only symptoms indicating necessity for new better therapies. One of them could be based on the inhibition of butyrylcholinesterase (BuChE) because of its increased activity during late stage of AD. Therefore, the BuChE inhibitors should be of great importance in therapy. 1,2,3,4-tetrahydroisoquinolines (THIQ) are a large group of natural and synthetic compounds which exert diverse biological activities against various infectious pathogens and neurodegenerative disorders. Due to these reasons, the THIQ have attracted a lot of attention in the scientific community which has resulted in the development of novel THIQ analogues with more potent biological activity. In this study the inhibitory potency of derivates of N-phenyl-1,2,3,4- tetrahydroisoquinoline, 178, 196 and 202, were investigated toward two cholinergic enzymes, AChE and BuChE. The performed screening tests pointed out the different inhibition potency of the selected compounds toward both enzymes which was related with their structures. The most potent compound has been 178 with IC50 values 1.30 μM and 2.50 μM toward AChE and BuChE, respectively. However, no selectivity was observed. Introducing F-atom in the para position of N-phenyl group of the compound 178, the compound 202 was obtained. In this way, the selectivity was increased towards acetylcholinesterase without significant influence on the IC50 value. However, introducing a methoxy groups in the position C3 and C4 of the tetrahydroisoquinoline’s ring of 202, the compound 196 with decreased inhibitory activity was obtained. IC50 value of 196 was one order of magnitude higher compared with compound 202. Based on the obtained results it is possible to conclude that introducing F atom in the para position of the phenyl ring lead to increased selectivity of the investigated compounds while introducing methoxy group in the position of C3 and C4 of tetrahydroisoquinoline ring leads to decrease of their inhibitory potency.
PB  - Niš : RAD Centre
C3  - RAD 2023 : 11th International Conference on Radiation Natural Sciences, Medicine, Engineering, Technology and Ecology : Book of Abstracts
T1  - Influence of the structures of THIQ derivatives on their inhibitory properties toward acetyl- and butyrylcholinesterase
SP  - 134
EP  - 134
DO  - 10.21175/rad.abstr.book.2023.23.2
ER  - 

@conference{
author = "Jovanović, Dunja and Filipović, Ana and Bondžić, Bojan and Bondžić, Aleksandra",
year = "2023",
abstract = "Alzheimer's disease (AD), the most common form of dementia, is a progressive neurological disorder characterized by losing memory and other intellectual abilities that are serious enough to interfere with daily life. The disease is associated with loss of cholinergic neurons in the brain and the decreased level of ACh. In order to raise the ACh level in the brain the acetylcholinesterase (AChE) inhibitors have been applied as relevant drugs in the AD therapy. On the other hand, these inhibitors treat and improve only symptoms indicating necessity for new better therapies. One of them could be based on the inhibition of butyrylcholinesterase (BuChE) because of its increased activity during late stage of AD. Therefore, the BuChE inhibitors should be of great importance in therapy. 1,2,3,4-tetrahydroisoquinolines (THIQ) are a large group of natural and synthetic compounds which exert diverse biological activities against various infectious pathogens and neurodegenerative disorders. Due to these reasons, the THIQ have attracted a lot of attention in the scientific community which has resulted in the development of novel THIQ analogues with more potent biological activity. In this study the inhibitory potency of derivates of N-phenyl-1,2,3,4- tetrahydroisoquinoline, 178, 196 and 202, were investigated toward two cholinergic enzymes, AChE and BuChE. The performed screening tests pointed out the different inhibition potency of the selected compounds toward both enzymes which was related with their structures. The most potent compound has been 178 with IC50 values 1.30 μM and 2.50 μM toward AChE and BuChE, respectively. However, no selectivity was observed. Introducing F-atom in the para position of N-phenyl group of the compound 178, the compound 202 was obtained. In this way, the selectivity was increased towards acetylcholinesterase without significant influence on the IC50 value. However, introducing a methoxy groups in the position C3 and C4 of the tetrahydroisoquinoline’s ring of 202, the compound 196 with decreased inhibitory activity was obtained. IC50 value of 196 was one order of magnitude higher compared with compound 202. Based on the obtained results it is possible to conclude that introducing F atom in the para position of the phenyl ring lead to increased selectivity of the investigated compounds while introducing methoxy group in the position of C3 and C4 of tetrahydroisoquinoline ring leads to decrease of their inhibitory potency.",
publisher = "Niš : RAD Centre",
journal = "RAD 2023 : 11th International Conference on Radiation Natural Sciences, Medicine, Engineering, Technology and Ecology : Book of Abstracts",
title = "Influence of the structures of THIQ derivatives on their inhibitory properties toward acetyl- and butyrylcholinesterase",
pages = "134-134",
doi = "10.21175/rad.abstr.book.2023.23.2"
}

Jovanović, D., Filipović, A., Bondžić, B.,& Bondžić, A.. (2023). Influence of the structures of THIQ derivatives on their inhibitory properties toward acetyl- and butyrylcholinesterase. in RAD 2023 : 11th International Conference on Radiation Natural Sciences, Medicine, Engineering, Technology and Ecology : Book of Abstracts
Niš : RAD Centre., 134-134.
https://doi.org/10.21175/rad.abstr.book.2023.23.2

Jovanović D, Filipović A, Bondžić B, Bondžić A. Influence of the structures of THIQ derivatives on their inhibitory properties toward acetyl- and butyrylcholinesterase. in RAD 2023 : 11th International Conference on Radiation Natural Sciences, Medicine, Engineering, Technology and Ecology : Book of Abstracts. 2023;:134-134.
doi:10.21175/rad.abstr.book.2023.23.2 .

Jovanović, Dunja, Filipović, Ana, Bondžić, Bojan, Bondžić, Aleksandra, "Influence of the structures of THIQ derivatives on their inhibitory properties toward acetyl- and butyrylcholinesterase" in RAD 2023 : 11th International Conference on Radiation Natural Sciences, Medicine, Engineering, Technology and Ecology : Book of Abstracts (2023):134-134,
https://doi.org/10.21175/rad.abstr.book.2023.23.2 . .

TY  - JOUR
AU  - Bondžić, Aleksandra M.
AU  - Jovanović, Dunja
AU  - Arsenijević, Nevena
AU  - Laban, Bojana
AU  - Lazarević-Pašti, Tamara
AU  - Klekotka, Urszula
AU  - Bondžić, Bojan P.
PY  - 2022
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10404
AB  - The study of the interactions between nanoparticles (NPs) and proteins has had a pivotal role in facilitating the understanding of biological effects and safe application of NPs after exposure to the physiological environment. Herein, for the first time, the interaction between L-methionine capped silver nanoparticles (AgMet), and bovine serum albumin (BSA) is investigated in order to predict the fate of AgMet after its contact with the most abundant blood transport protein. The detailed insights into the mechanism of interaction were achieved using different physicochemical techniques. The UV/Vis, TEM, and DLS were used for the characterization of the newly formed “entity”, while the kinetic and thermodynamic parameters were utilized to describe the adsorption process. Additionally, the fluorescence quenching and synchronous fluorescence studies enabled the prediction of the binding affinity and gave us insight into the influence of the adsorption on the conformation state of the BSA. According to the best of our knowledge, for the first time, we show that BSA can be used as an external stabilizer agent which is able to induce the peptization of previously agglomerated AgMet. We believe that the obtained results could contribute to further improvement of AgNPs’ performances as well as to the understanding of their in vivo behavior, which could contribute to their potential use in preclinical research studies.
T2  - International Journal of Molecular Sciences
T1  - “Soft Protein Corona” as the Stabilizer of the Methionine-Coated Silver Nanoparticles in the Physiological Environment: Insights into the Mechanism of the Interaction
VL  - 23
IS  - 16
SP  - 8985
DO  - 10.3390/ijms23168985
ER  - 

@article{
author = "Bondžić, Aleksandra M. and Jovanović, Dunja and Arsenijević, Nevena and Laban, Bojana and Lazarević-Pašti, Tamara and Klekotka, Urszula and Bondžić, Bojan P.",
year = "2022",
abstract = "The study of the interactions between nanoparticles (NPs) and proteins has had a pivotal role in facilitating the understanding of biological effects and safe application of NPs after exposure to the physiological environment. Herein, for the first time, the interaction between L-methionine capped silver nanoparticles (AgMet), and bovine serum albumin (BSA) is investigated in order to predict the fate of AgMet after its contact with the most abundant blood transport protein. The detailed insights into the mechanism of interaction were achieved using different physicochemical techniques. The UV/Vis, TEM, and DLS were used for the characterization of the newly formed “entity”, while the kinetic and thermodynamic parameters were utilized to describe the adsorption process. Additionally, the fluorescence quenching and synchronous fluorescence studies enabled the prediction of the binding affinity and gave us insight into the influence of the adsorption on the conformation state of the BSA. According to the best of our knowledge, for the first time, we show that BSA can be used as an external stabilizer agent which is able to induce the peptization of previously agglomerated AgMet. We believe that the obtained results could contribute to further improvement of AgNPs’ performances as well as to the understanding of their in vivo behavior, which could contribute to their potential use in preclinical research studies.",
journal = "International Journal of Molecular Sciences",
title = "“Soft Protein Corona” as the Stabilizer of the Methionine-Coated Silver Nanoparticles in the Physiological Environment: Insights into the Mechanism of the Interaction",
volume = "23",
number = "16",
pages = "8985",
doi = "10.3390/ijms23168985"
}

Bondžić, A. M., Jovanović, D., Arsenijević, N., Laban, B., Lazarević-Pašti, T., Klekotka, U.,& Bondžić, B. P.. (2022). “Soft Protein Corona” as the Stabilizer of the Methionine-Coated Silver Nanoparticles in the Physiological Environment: Insights into the Mechanism of the Interaction. in International Journal of Molecular Sciences, 23(16), 8985.
https://doi.org/10.3390/ijms23168985

Bondžić AM, Jovanović D, Arsenijević N, Laban B, Lazarević-Pašti T, Klekotka U, Bondžić BP. “Soft Protein Corona” as the Stabilizer of the Methionine-Coated Silver Nanoparticles in the Physiological Environment: Insights into the Mechanism of the Interaction. in International Journal of Molecular Sciences. 2022;23(16):8985.
doi:10.3390/ijms23168985 .

Bondžić, Aleksandra M., Jovanović, Dunja, Arsenijević, Nevena, Laban, Bojana, Lazarević-Pašti, Tamara, Klekotka, Urszula, Bondžić, Bojan P., "“Soft Protein Corona” as the Stabilizer of the Methionine-Coated Silver Nanoparticles in the Physiological Environment: Insights into the Mechanism of the Interaction" in International Journal of Molecular Sciences, 23, no. 16 (2022):8985,
https://doi.org/10.3390/ijms23168985 . .

TY  - CONF
AU  - Bondžić, Aleksandra
AU  - Jovanović, Dunja
PY  - 2022
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/12681
AB  - The main goal of this work was the elucidation of the binding interactions between bovine serum
albumin (BSA) and methionine coated silver nanoparticles (AgNPs) under physiological like
conditions using fluorescence spectroscopy techniques. The quenching of BSA’s tryptophan
fluorescence has occurred at the concentration-dependent manner. The linear shape obtained for
Stern-Volmer plots and its larger slope at higher temperatures indicated mixed static and dynamic
quenching mechanisms. The values of quenching constants, Ksv and the bimolecular quenching rate
constants, kq, pointed out the existence of binding interactions between BSA and AgNPs. The
binding constants, K, with values around 1 × 104
 M-1, indicated low to moderate binding interaction
with one binding site. Determined thermodynamic parameters ΔHo < 0, ΔSo < 0 and ΔGo
 < 0 at different temperatures pointed out spontaneous processes, where hydrogen and van der Waals
interactions play a major role in the binding.
PB  - Belgrade : Society of Physical Chemists of Serbia
C3  - PHYSICAL CHEMISTRY 2022 : 16th International Conference on Fundamental and Applied Aspects of Physical Chemistry : Proceedings
T1  - Quenching of bovine serum albumin fluorescence by methionine coated silver nanoparticles: Insight in the mechanism of interaction
VL  - 2
SP  - 609
EP  - 612
UR  - https://hdl.handle.net/21.15107/rcub_vinar_12681
ER  - 

@conference{
author = "Bondžić, Aleksandra and Jovanović, Dunja",
year = "2022",
abstract = "The main goal of this work was the elucidation of the binding interactions between bovine serum
albumin (BSA) and methionine coated silver nanoparticles (AgNPs) under physiological like
conditions using fluorescence spectroscopy techniques. The quenching of BSA’s tryptophan
fluorescence has occurred at the concentration-dependent manner. The linear shape obtained for
Stern-Volmer plots and its larger slope at higher temperatures indicated mixed static and dynamic
quenching mechanisms. The values of quenching constants, Ksv and the bimolecular quenching rate
constants, kq, pointed out the existence of binding interactions between BSA and AgNPs. The
binding constants, K, with values around 1 × 104
 M-1, indicated low to moderate binding interaction
with one binding site. Determined thermodynamic parameters ΔHo < 0, ΔSo < 0 and ΔGo
 < 0 at different temperatures pointed out spontaneous processes, where hydrogen and van der Waals
interactions play a major role in the binding.",
publisher = "Belgrade : Society of Physical Chemists of Serbia",
journal = "PHYSICAL CHEMISTRY 2022 : 16th International Conference on Fundamental and Applied Aspects of Physical Chemistry : Proceedings",
title = "Quenching of bovine serum albumin fluorescence by methionine coated silver nanoparticles: Insight in the mechanism of interaction",
volume = "2",
pages = "609-612",
url = "https://hdl.handle.net/21.15107/rcub_vinar_12681"
}

Bondžić, A.,& Jovanović, D.. (2022). Quenching of bovine serum albumin fluorescence by methionine coated silver nanoparticles: Insight in the mechanism of interaction. in PHYSICAL CHEMISTRY 2022 : 16th International Conference on Fundamental and Applied Aspects of Physical Chemistry : Proceedings
Belgrade : Society of Physical Chemists of Serbia., 2, 609-612.
https://hdl.handle.net/21.15107/rcub_vinar_12681

Bondžić A, Jovanović D. Quenching of bovine serum albumin fluorescence by methionine coated silver nanoparticles: Insight in the mechanism of interaction. in PHYSICAL CHEMISTRY 2022 : 16th International Conference on Fundamental and Applied Aspects of Physical Chemistry : Proceedings. 2022;2:609-612.
https://hdl.handle.net/21.15107/rcub_vinar_12681 .

Bondžić, Aleksandra, Jovanović, Dunja, "Quenching of bovine serum albumin fluorescence by methionine coated silver nanoparticles: Insight in the mechanism of interaction" in PHYSICAL CHEMISTRY 2022 : 16th International Conference on Fundamental and Applied Aspects of Physical Chemistry : Proceedings, 2 (2022):609-612,
https://hdl.handle.net/21.15107/rcub_vinar_12681 .

TY  - CONF
AU  - Bondžić, Aleksandra
AU  - Jovanović, Dunja
AU  - Džambaski, Zdravko
AU  - Filipović, Ana
AU  - Bondžić, Bojan
PY  - 2022
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/12366
AB  - The goal of this work was to investigate the inhibitory potency of three derivates of 2- phenyl-1,2,3,4-tetrahydroisoquinoline (THIQ) with different substituents at C3 and C4 positions, namely 65P,71P and 66P, toward two cholinergic enzymes, acetyl and butyrylcholinesterase. The screening test showed that only compound 65P possesses inhibition activity higher than 50 % at 10 μM concentration toward both enzymes. The inhibition potency obtained at 10 μM of THIQ was correlated with differences in THIQ’s structures in order to predict the structure-activity relationship. It was found that the introduction of the methoxy group at positions C3 and C4 led to decreased inhibition potency, while the removing of fluorine atom from the benzene ring increases selectivity toward acetylcholinesterase. The IC50 value gained during the evaluation of inhibition activity of 65P indicated strong inhibition potency of this compound, while Hill’s coefficient ~ 1 indicated the non-existence of cooperativity and one binding site on both enzymes clearly indicating that THIQ could be promising therapeutic drugs in the treatment of Alzheimer’s disease.
PB  - Belgrade : Society of Physical Chemists of Serbia
C3  - PHYSICAL CHEMISTRY 2022 : 16th International Conference on Fundamental and Applied Aspects of Physical Chemistry : Book of abstracts
T1  - New derivates of 2-phenyl-1,2,3,4-tetrahydroizoquinoline as dual inhibitors of cholinergic enzymes
SP  - 170
EP  - 170
UR  - https://hdl.handle.net/21.15107/rcub_vinar_12366
ER  - 

@conference{
author = "Bondžić, Aleksandra and Jovanović, Dunja and Džambaski, Zdravko and Filipović, Ana and Bondžić, Bojan",
year = "2022",
abstract = "The goal of this work was to investigate the inhibitory potency of three derivates of 2- phenyl-1,2,3,4-tetrahydroisoquinoline (THIQ) with different substituents at C3 and C4 positions, namely 65P,71P and 66P, toward two cholinergic enzymes, acetyl and butyrylcholinesterase. The screening test showed that only compound 65P possesses inhibition activity higher than 50 % at 10 μM concentration toward both enzymes. The inhibition potency obtained at 10 μM of THIQ was correlated with differences in THIQ’s structures in order to predict the structure-activity relationship. It was found that the introduction of the methoxy group at positions C3 and C4 led to decreased inhibition potency, while the removing of fluorine atom from the benzene ring increases selectivity toward acetylcholinesterase. The IC50 value gained during the evaluation of inhibition activity of 65P indicated strong inhibition potency of this compound, while Hill’s coefficient ~ 1 indicated the non-existence of cooperativity and one binding site on both enzymes clearly indicating that THIQ could be promising therapeutic drugs in the treatment of Alzheimer’s disease.",
publisher = "Belgrade : Society of Physical Chemists of Serbia",
journal = "PHYSICAL CHEMISTRY 2022 : 16th International Conference on Fundamental and Applied Aspects of Physical Chemistry : Book of abstracts",
title = "New derivates of 2-phenyl-1,2,3,4-tetrahydroizoquinoline as dual inhibitors of cholinergic enzymes",
pages = "170-170",
url = "https://hdl.handle.net/21.15107/rcub_vinar_12366"
}

Bondžić, A., Jovanović, D., Džambaski, Z., Filipović, A.,& Bondžić, B.. (2022). New derivates of 2-phenyl-1,2,3,4-tetrahydroizoquinoline as dual inhibitors of cholinergic enzymes. in PHYSICAL CHEMISTRY 2022 : 16th International Conference on Fundamental and Applied Aspects of Physical Chemistry : Book of abstracts
Belgrade : Society of Physical Chemists of Serbia., 170-170.
https://hdl.handle.net/21.15107/rcub_vinar_12366

Bondžić A, Jovanović D, Džambaski Z, Filipović A, Bondžić B. New derivates of 2-phenyl-1,2,3,4-tetrahydroizoquinoline as dual inhibitors of cholinergic enzymes. in PHYSICAL CHEMISTRY 2022 : 16th International Conference on Fundamental and Applied Aspects of Physical Chemistry : Book of abstracts. 2022;:170-170.
https://hdl.handle.net/21.15107/rcub_vinar_12366 .

Bondžić, Aleksandra, Jovanović, Dunja, Džambaski, Zdravko, Filipović, Ana, Bondžić, Bojan, "New derivates of 2-phenyl-1,2,3,4-tetrahydroizoquinoline as dual inhibitors of cholinergic enzymes" in PHYSICAL CHEMISTRY 2022 : 16th International Conference on Fundamental and Applied Aspects of Physical Chemistry : Book of abstracts (2022):170-170,
https://hdl.handle.net/21.15107/rcub_vinar_12366 .

TY  - CONF
AU  - Bondžić, Aleksandra
AU  - Jovanović, Dunja
AU  - Leskovac, Andreja
AU  - Džambaski, Zdravko
AU  - Bondžić, Bojan
PY  - 2021
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/11683
AB  - In this study, the kinetics of bovine serum albumin (BSA) adsorption from aqueous solutions on the
methionine stabilized silver nanoparticles (AgNPs) was investigated. The influence of the parameters
such as contact time and BSA initial concentration on the adsorption capacity of AgNPs were tested.
By increasing the contact time up to 30 min, the percentage of adsorbed BSA was increased. After
this time, no changes were observed, indicating that the equilibrium state was reached. Investigation
of the initial concentration-effect showed that the percentage of BSA adsorption increased with
increasing BSA concentration until the available binding sites were saturated. After that, more BSA
molecules were left unadsorbed. To elucidate the adsorption kinetic, pseudo-first-order, pseudosecond-order, and intraparticle diffusion kinetic models were applied. The pseudo-second-order well
described the adsorption process and intraparticle diffusion model rate laws, and the intraparticle
diffusion is the sole rate-controlling step.
PB  - The Society of Physical Chemists of Serbia
C3  - 15th International Conference on Fundamental and Applied Aspects of Physical Chemistry - Physical Chemistry 2021 : proceedings, Volume I, September 20-24
T1  - Kinetics of adsorption of the bovine serum albumin on the silver nanoparticles
SP  - 332
EP  - 335
UR  - https://hdl.handle.net/21.15107/rcub_vinar_11683
ER  - 

@conference{
author = "Bondžić, Aleksandra and Jovanović, Dunja and Leskovac, Andreja and Džambaski, Zdravko and Bondžić, Bojan",
year = "2021",
abstract = "In this study, the kinetics of bovine serum albumin (BSA) adsorption from aqueous solutions on the
methionine stabilized silver nanoparticles (AgNPs) was investigated. The influence of the parameters
such as contact time and BSA initial concentration on the adsorption capacity of AgNPs were tested.
By increasing the contact time up to 30 min, the percentage of adsorbed BSA was increased. After
this time, no changes were observed, indicating that the equilibrium state was reached. Investigation
of the initial concentration-effect showed that the percentage of BSA adsorption increased with
increasing BSA concentration until the available binding sites were saturated. After that, more BSA
molecules were left unadsorbed. To elucidate the adsorption kinetic, pseudo-first-order, pseudosecond-order, and intraparticle diffusion kinetic models were applied. The pseudo-second-order well
described the adsorption process and intraparticle diffusion model rate laws, and the intraparticle
diffusion is the sole rate-controlling step.",
publisher = "The Society of Physical Chemists of Serbia",
journal = "15th International Conference on Fundamental and Applied Aspects of Physical Chemistry - Physical Chemistry 2021 : proceedings, Volume I, September 20-24",
title = "Kinetics of adsorption of the bovine serum albumin on the silver nanoparticles",
pages = "332-335",
url = "https://hdl.handle.net/21.15107/rcub_vinar_11683"
}

Bondžić, A., Jovanović, D., Leskovac, A., Džambaski, Z.,& Bondžić, B.. (2021). Kinetics of adsorption of the bovine serum albumin on the silver nanoparticles. in 15th International Conference on Fundamental and Applied Aspects of Physical Chemistry - Physical Chemistry 2021 : proceedings, Volume I, September 20-24
The Society of Physical Chemists of Serbia., 332-335.
https://hdl.handle.net/21.15107/rcub_vinar_11683

Bondžić A, Jovanović D, Leskovac A, Džambaski Z, Bondžić B. Kinetics of adsorption of the bovine serum albumin on the silver nanoparticles. in 15th International Conference on Fundamental and Applied Aspects of Physical Chemistry - Physical Chemistry 2021 : proceedings, Volume I, September 20-24. 2021;:332-335.
https://hdl.handle.net/21.15107/rcub_vinar_11683 .

Bondžić, Aleksandra, Jovanović, Dunja, Leskovac, Andreja, Džambaski, Zdravko, Bondžić, Bojan, "Kinetics of adsorption of the bovine serum albumin on the silver nanoparticles" in 15th International Conference on Fundamental and Applied Aspects of Physical Chemistry - Physical Chemistry 2021 : proceedings, Volume I, September 20-24 (2021):332-335,
https://hdl.handle.net/21.15107/rcub_vinar_11683 .