TY  - CONF
AU  - Milošević, Maja
AU  - Banjac, Ana
AU  - Demajo, Miroslav
AU  - Horvat, Anica
PY  - 2006
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/9428
AB  - The effects of ethylenediamine tetraacetic acid (EDTA) on the CdCl2 cell toxicity was examined on rat myometrium. Activity of plasma membrane ecto-ATPase, as modulator of purinergic signaling in the presence of increasing concentrations of cadmium salt and in the presence or absence of EDTA were studied. The EDTA, chelating cadmium ions decrease inhibitory cadmium potency by increasing half-maximum inhibitory activities of this ion.
PB  - Society of Physical Chemists of Serbia
C3  - Physical chemistry 2006: 8th international conference on fundemental and applied aspract of physical chemistry
T1  - Effect of EDTA on the inhibition of rat myometrial ecto-ATPase activity in the presence of heavy metal ions II. cadmium
SP  - 398
EP  - 400
UR  - https://hdl.handle.net/21.15107/rcub_vinar_9428
ER  - 

@conference{
author = "Milošević, Maja and Banjac, Ana and Demajo, Miroslav and Horvat, Anica",
year = "2006",
abstract = "The effects of ethylenediamine tetraacetic acid (EDTA) on the CdCl2 cell toxicity was examined on rat myometrium. Activity of plasma membrane ecto-ATPase, as modulator of purinergic signaling in the presence of increasing concentrations of cadmium salt and in the presence or absence of EDTA were studied. The EDTA, chelating cadmium ions decrease inhibitory cadmium potency by increasing half-maximum inhibitory activities of this ion.",
publisher = "Society of Physical Chemists of Serbia",
journal = "Physical chemistry 2006: 8th international conference on fundemental and applied aspract of physical chemistry",
title = "Effect of EDTA on the inhibition of rat myometrial ecto-ATPase activity in the presence of heavy metal ions II. cadmium",
pages = "398-400",
url = "https://hdl.handle.net/21.15107/rcub_vinar_9428"
}

Milošević, M., Banjac, A., Demajo, M.,& Horvat, A.. (2006). Effect of EDTA on the inhibition of rat myometrial ecto-ATPase activity in the presence of heavy metal ions II. cadmium. in Physical chemistry 2006: 8th international conference on fundemental and applied aspract of physical chemistry
Society of Physical Chemists of Serbia., 398-400.
https://hdl.handle.net/21.15107/rcub_vinar_9428

Milošević M, Banjac A, Demajo M, Horvat A. Effect of EDTA on the inhibition of rat myometrial ecto-ATPase activity in the presence of heavy metal ions II. cadmium. in Physical chemistry 2006: 8th international conference on fundemental and applied aspract of physical chemistry. 2006;:398-400.
https://hdl.handle.net/21.15107/rcub_vinar_9428 .

Milošević, Maja, Banjac, Ana, Demajo, Miroslav, Horvat, Anica, "Effect of EDTA on the inhibition of rat myometrial ecto-ATPase activity in the presence of heavy metal ions II. cadmium" in Physical chemistry 2006: 8th international conference on fundemental and applied aspract of physical chemistry (2006):398-400,
https://hdl.handle.net/21.15107/rcub_vinar_9428 .

TY  - JOUR
AU  - Horvat, Anica
AU  - Momić, Tatjana
AU  - Banjac, Ana
AU  - Petrović S.
AU  - Nikezić, Gordana S.
AU  - Demajo, Miroslav
PY  - 2006
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/3040
AB  - The effect of drugs from the class of cardiac (methyldigoxin, verapamil, propranolol), antiepileptic ( carbamazepine), sedative (diazepam) and antihistaminic (promethazine) drugs on Na,K-ATPase activity of plasma membranes was studied in rat brain synaptosomes. Methyldigoxin in a concentration of 0.1 mmol/l inhibits enzyme activity by 80%. Verapamil, propranolol and promethazine in concentrations of 20, 20 and 2 mmol/l respectively, entirely inhibit the ATPase activity. Carbamazepine and diazepam in concentrations of 0.02-60 mmol/l have no effect on the activity of this enzyme. According to the drug concentrations that inhibit 50% of enzyme activity (IC50), the potency can be listed in the following order: methyldigoxin GT GT promethazine GT verapamil GT = propranolol. From the inhibition of commercially available purified Na, K-ATPase isolated from porcine cerebral cortex in the presence of chosen drugs, as well as from kinetic studies on synaptosomal plasma membranes, it may be concluded that the drugs inhibit enzyme activity, partly by acting directly on the enzyme proteins. Propranolol, verapamil and promethazine inhibitions acted in an uncompetitive manner. The results suggest that these three drugs may contribute to neurological dysfunctions and indicate the necessity to take into consideration the side effects of the investigated drugs during the treatment of various pathological conditions.
T2  - Physiological Research
T1  - Selective inhibition of brain Na,K-ATPase by drugs
VL  - 55
IS  - 3
SP  - 325
EP  - 338
UR  - https://hdl.handle.net/21.15107/rcub_vinar_3040
ER  - 

@article{
author = "Horvat, Anica and Momić, Tatjana and Banjac, Ana and Petrović S. and Nikezić, Gordana S. and Demajo, Miroslav",
year = "2006",
abstract = "The effect of drugs from the class of cardiac (methyldigoxin, verapamil, propranolol), antiepileptic ( carbamazepine), sedative (diazepam) and antihistaminic (promethazine) drugs on Na,K-ATPase activity of plasma membranes was studied in rat brain synaptosomes. Methyldigoxin in a concentration of 0.1 mmol/l inhibits enzyme activity by 80%. Verapamil, propranolol and promethazine in concentrations of 20, 20 and 2 mmol/l respectively, entirely inhibit the ATPase activity. Carbamazepine and diazepam in concentrations of 0.02-60 mmol/l have no effect on the activity of this enzyme. According to the drug concentrations that inhibit 50% of enzyme activity (IC50), the potency can be listed in the following order: methyldigoxin GT GT promethazine GT verapamil GT = propranolol. From the inhibition of commercially available purified Na, K-ATPase isolated from porcine cerebral cortex in the presence of chosen drugs, as well as from kinetic studies on synaptosomal plasma membranes, it may be concluded that the drugs inhibit enzyme activity, partly by acting directly on the enzyme proteins. Propranolol, verapamil and promethazine inhibitions acted in an uncompetitive manner. The results suggest that these three drugs may contribute to neurological dysfunctions and indicate the necessity to take into consideration the side effects of the investigated drugs during the treatment of various pathological conditions.",
journal = "Physiological Research",
title = "Selective inhibition of brain Na,K-ATPase by drugs",
volume = "55",
number = "3",
pages = "325-338",
url = "https://hdl.handle.net/21.15107/rcub_vinar_3040"
}

Horvat, A., Momić, T., Banjac, A., Petrović S., Nikezić, G. S.,& Demajo, M.. (2006). Selective inhibition of brain Na,K-ATPase by drugs. in Physiological Research, 55(3), 325-338.
https://hdl.handle.net/21.15107/rcub_vinar_3040

Horvat A, Momić T, Banjac A, Petrović S., Nikezić GS, Demajo M. Selective inhibition of brain Na,K-ATPase by drugs. in Physiological Research. 2006;55(3):325-338.
https://hdl.handle.net/21.15107/rcub_vinar_3040 .

Horvat, Anica, Momić, Tatjana, Banjac, Ana, Petrović S., Nikezić, Gordana S., Demajo, Miroslav, "Selective inhibition of brain Na,K-ATPase by drugs" in Physiological Research, 55, no. 3 (2006):325-338,
https://hdl.handle.net/21.15107/rcub_vinar_3040 .