TY  - JOUR
AU  - Stamenković, Gorana
AU  - Božić, Milena
AU  - Jovanović-Ćupić, Snežana P.
AU  - Bojovic, Ksenija
AU  - Simonovic, Jasmina
PY  - 2007
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/3417
T2  - Archives of Biological Sciences
T1  - Hepatitis C virus as cause of fulminant hepatitis-sequence analysis of the 5nontranslated region
VL  - 59
IS  - 3
SP  - 37P
EP  - 38P
DO  - 10.2298/ABS070337PS
ER  - 

@article{
author = "Stamenković, Gorana and Božić, Milena and Jovanović-Ćupić, Snežana P. and Bojovic, Ksenija and Simonovic, Jasmina",
year = "2007",
journal = "Archives of Biological Sciences",
title = "Hepatitis C virus as cause of fulminant hepatitis-sequence analysis of the 5nontranslated region",
volume = "59",
number = "3",
pages = "37P-38P",
doi = "10.2298/ABS070337PS"
}

Stamenković, G., Božić, M., Jovanović-Ćupić, S. P., Bojovic, K.,& Simonovic, J.. (2007). Hepatitis C virus as cause of fulminant hepatitis-sequence analysis of the 5nontranslated region. in Archives of Biological Sciences, 59(3), 37P-38P.
https://doi.org/10.2298/ABS070337PS

Stamenković G, Božić M, Jovanović-Ćupić SP, Bojovic K, Simonovic J. Hepatitis C virus as cause of fulminant hepatitis-sequence analysis of the 5nontranslated region. in Archives of Biological Sciences. 2007;59(3):37P-38P.
doi:10.2298/ABS070337PS .

Stamenković, Gorana, Božić, Milena, Jovanović-Ćupić, Snežana P., Bojovic, Ksenija, Simonovic, Jasmina, "Hepatitis C virus as cause of fulminant hepatitis-sequence analysis of the 5nontranslated region" in Archives of Biological Sciences, 59, no. 3 (2007):37P-38P,
https://doi.org/10.2298/ABS070337PS . .

TY  - JOUR
AU  - Svirtlih, Neda
AU  - Jevtović, Đorđe
AU  - Simonovic, Jasmina
AU  - Delic, Dragan
AU  - Dokic, Ljubisa
AU  - Gvozdenovic, Eleonora
AU  - Boricic, Ivan
AU  - Nesic, Zorica
AU  - Neskovic, Gorana
AU  - Urban, Vladimir
PY  - 2007
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/3335
AB  - Background/Aims: Progression of chronic hepatitis C depends on the host and viral characteristics, duration of infection, co-infection with other viruses, etc. In this study, some of demographic, epidemiological and viral data as risk factors for a degree of liver fibrosis were evaluated. Methodology: A total of 144 patients was investigated (89 males, ages from 16-65 years) classified into two groups, with fibrosis scores 0-3 and 4-6, using the Ishak scoring system. Significant variables were entered into univariate logistic regression model and further multivariate analysis was performed. Results: There were 64% and 36% of patients with fibrosis scores 0-3 and 4-6, respectively. Gender, moderate to heavy alcohol abuse and high viral RNA were equally distributed between both groups. In univariate analysis, the age older than 40, history of intravenous drug abuse, and the genotype 1b were independently associated with different fibrosis scores. Multivariate regression analysis revealed ages older than 40 as the positive (p LT 0.001), and younger than 40 as the negative predictive factors for fibrosis scores 4-6 and 0-3 (p LT 0.001), respectively. Conclusions: Our results indicate the age over 40 at the time of liver biopsy as the important risk factor for advanced liver disease in chronic hepatitis C according to fibrosis scores.
T2  - Hepato-gastroenterology
T1  - Older age at the time of liver biopsy is the important risk factor for advanced fibrosis in patients with chronic hepatitis C
VL  - 54
IS  - 80
SP  - 2324
EP  - 2327
UR  - https://hdl.handle.net/21.15107/rcub_vinar_3335
ER  - 

@article{
author = "Svirtlih, Neda and Jevtović, Đorđe and Simonovic, Jasmina and Delic, Dragan and Dokic, Ljubisa and Gvozdenovic, Eleonora and Boricic, Ivan and Nesic, Zorica and Neskovic, Gorana and Urban, Vladimir",
year = "2007",
abstract = "Background/Aims: Progression of chronic hepatitis C depends on the host and viral characteristics, duration of infection, co-infection with other viruses, etc. In this study, some of demographic, epidemiological and viral data as risk factors for a degree of liver fibrosis were evaluated. Methodology: A total of 144 patients was investigated (89 males, ages from 16-65 years) classified into two groups, with fibrosis scores 0-3 and 4-6, using the Ishak scoring system. Significant variables were entered into univariate logistic regression model and further multivariate analysis was performed. Results: There were 64% and 36% of patients with fibrosis scores 0-3 and 4-6, respectively. Gender, moderate to heavy alcohol abuse and high viral RNA were equally distributed between both groups. In univariate analysis, the age older than 40, history of intravenous drug abuse, and the genotype 1b were independently associated with different fibrosis scores. Multivariate regression analysis revealed ages older than 40 as the positive (p LT 0.001), and younger than 40 as the negative predictive factors for fibrosis scores 4-6 and 0-3 (p LT 0.001), respectively. Conclusions: Our results indicate the age over 40 at the time of liver biopsy as the important risk factor for advanced liver disease in chronic hepatitis C according to fibrosis scores.",
journal = "Hepato-gastroenterology",
title = "Older age at the time of liver biopsy is the important risk factor for advanced fibrosis in patients with chronic hepatitis C",
volume = "54",
number = "80",
pages = "2324-2327",
url = "https://hdl.handle.net/21.15107/rcub_vinar_3335"
}

Svirtlih, N., Jevtović, Đ., Simonovic, J., Delic, D., Dokic, L., Gvozdenovic, E., Boricic, I., Nesic, Z., Neskovic, G.,& Urban, V.. (2007). Older age at the time of liver biopsy is the important risk factor for advanced fibrosis in patients with chronic hepatitis C. in Hepato-gastroenterology, 54(80), 2324-2327.
https://hdl.handle.net/21.15107/rcub_vinar_3335

Svirtlih N, Jevtović Đ, Simonovic J, Delic D, Dokic L, Gvozdenovic E, Boricic I, Nesic Z, Neskovic G, Urban V. Older age at the time of liver biopsy is the important risk factor for advanced fibrosis in patients with chronic hepatitis C. in Hepato-gastroenterology. 2007;54(80):2324-2327.
https://hdl.handle.net/21.15107/rcub_vinar_3335 .

Svirtlih, Neda, Jevtović, Đorđe, Simonovic, Jasmina, Delic, Dragan, Dokic, Ljubisa, Gvozdenovic, Eleonora, Boricic, Ivan, Nesic, Zorica, Neskovic, Gorana, Urban, Vladimir, "Older age at the time of liver biopsy is the important risk factor for advanced fibrosis in patients with chronic hepatitis C" in Hepato-gastroenterology, 54, no. 80 (2007):2324-2327,
https://hdl.handle.net/21.15107/rcub_vinar_3335 .

TY  - JOUR
AU  - Svirtlih, Neda
AU  - Delic, Dragan
AU  - Simonovic, Jasmina
AU  - Jevtović, Đorđe
AU  - Dokic, Ljubisa
AU  - Gvozdenovic, Eleonora
AU  - Boricic, Ivan
AU  - Terzić, Dragica
AU  - Pavic, Sladjana
AU  - Neskovic, Gorana
AU  - Zerjav, Sonja
AU  - Urban, Vladimir
PY  - 2007
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/3142
AB  - AIM: To investigate the prevalence of hepatitis C virus (HCV) genotypes in Serbia and Montenegro and their influence on some clinical characteristics in patients with chronic HCV infection. METHODS: A total of 164 patients was investigated. Complete history route of infection, assessment of alcohol consumption, an abdominal ultrasound, standard biochemical tests and liver biopsy were done. Gene sequencing of 5 NTR type-specific PCR or commercial kits was performed for HCV genotyping and subtyping. The SPSS for Windows (version 10.0) was used for univariate regression analysis with further multivariate analysis. RESULTS: The genotypes 1, 2, 3, 4, 1b3a and 1b4 were present in 57.9%, 3.79/b, 23.2%, 6.7%, 6.7% and 1.8% of the patients, respectively. The genotype 1 (mainly the subtype 1b) was found to be independent of age in subjects older than 40 years, high viral load, more severe necro-inflammatory activity, advanced stage of fibrosis, and absence of intravenous drug abuse. The genotype 3a was associated with intravenous drug abuse and the age below 40. Multivariate analysis demonstrated age over 40 and intravenous drug abuse as the positive predictive factors for the genotypes 1b and 3a, respectively. CONCLUSION: In Serbia and Montenegro, the genotypes 1b and 3a predominate in patients with chronic HCV infection. The subtype 1b is characteristic of older patients, while the genotype 3a is common in drug abusers. Association of the subtype lb with advanced liver disease, higher viral load and histological activity suggests earlier infection with this genotype and eventually its increased pathogenicity. (c) 2007 The WJG Press. All rights reserved.
T2  - World Journal of Gastroenterology
T1  - Hepatitis C virus genotypes in Serbia and Montenegro: The prevalence and clinical significance
VL  - 13
IS  - 3
SP  - 355
EP  - 360
DO  - 10.3748/wjg.v13.i3.355
ER  - 

@article{
author = "Svirtlih, Neda and Delic, Dragan and Simonovic, Jasmina and Jevtović, Đorđe and Dokic, Ljubisa and Gvozdenovic, Eleonora and Boricic, Ivan and Terzić, Dragica and Pavic, Sladjana and Neskovic, Gorana and Zerjav, Sonja and Urban, Vladimir",
year = "2007",
abstract = "AIM: To investigate the prevalence of hepatitis C virus (HCV) genotypes in Serbia and Montenegro and their influence on some clinical characteristics in patients with chronic HCV infection. METHODS: A total of 164 patients was investigated. Complete history route of infection, assessment of alcohol consumption, an abdominal ultrasound, standard biochemical tests and liver biopsy were done. Gene sequencing of 5 NTR type-specific PCR or commercial kits was performed for HCV genotyping and subtyping. The SPSS for Windows (version 10.0) was used for univariate regression analysis with further multivariate analysis. RESULTS: The genotypes 1, 2, 3, 4, 1b3a and 1b4 were present in 57.9%, 3.79/b, 23.2%, 6.7%, 6.7% and 1.8% of the patients, respectively. The genotype 1 (mainly the subtype 1b) was found to be independent of age in subjects older than 40 years, high viral load, more severe necro-inflammatory activity, advanced stage of fibrosis, and absence of intravenous drug abuse. The genotype 3a was associated with intravenous drug abuse and the age below 40. Multivariate analysis demonstrated age over 40 and intravenous drug abuse as the positive predictive factors for the genotypes 1b and 3a, respectively. CONCLUSION: In Serbia and Montenegro, the genotypes 1b and 3a predominate in patients with chronic HCV infection. The subtype 1b is characteristic of older patients, while the genotype 3a is common in drug abusers. Association of the subtype lb with advanced liver disease, higher viral load and histological activity suggests earlier infection with this genotype and eventually its increased pathogenicity. (c) 2007 The WJG Press. All rights reserved.",
journal = "World Journal of Gastroenterology",
title = "Hepatitis C virus genotypes in Serbia and Montenegro: The prevalence and clinical significance",
volume = "13",
number = "3",
pages = "355-360",
doi = "10.3748/wjg.v13.i3.355"
}

Svirtlih, N., Delic, D., Simonovic, J., Jevtović, Đ., Dokic, L., Gvozdenovic, E., Boricic, I., Terzić, D., Pavic, S., Neskovic, G., Zerjav, S.,& Urban, V.. (2007). Hepatitis C virus genotypes in Serbia and Montenegro: The prevalence and clinical significance. in World Journal of Gastroenterology, 13(3), 355-360.
https://doi.org/10.3748/wjg.v13.i3.355

Svirtlih N, Delic D, Simonovic J, Jevtović Đ, Dokic L, Gvozdenovic E, Boricic I, Terzić D, Pavic S, Neskovic G, Zerjav S, Urban V. Hepatitis C virus genotypes in Serbia and Montenegro: The prevalence and clinical significance. in World Journal of Gastroenterology. 2007;13(3):355-360.
doi:10.3748/wjg.v13.i3.355 .

Svirtlih, Neda, Delic, Dragan, Simonovic, Jasmina, Jevtović, Đorđe, Dokic, Ljubisa, Gvozdenovic, Eleonora, Boricic, Ivan, Terzić, Dragica, Pavic, Sladjana, Neskovic, Gorana, Zerjav, Sonja, Urban, Vladimir, "Hepatitis C virus genotypes in Serbia and Montenegro: The prevalence and clinical significance" in World Journal of Gastroenterology, 13, no. 3 (2007):355-360,
https://doi.org/10.3748/wjg.v13.i3.355 . .