TY  - JOUR
AU  - Todorović, Ana
AU  - Bobić, Katarina
AU  - Veljković, Filip
AU  - Pejić, Snežana
AU  - Glumac, Sofija
AU  - Stanković, Sanja
AU  - Milovanović, Tijana
AU  - Vukoje, Ivana
AU  - Nedeljković, Jovan
AU  - Radojević Škodrić, Sanja
AU  - Pajović, Snežana B.
AU  - Drakulić, Dunja
PY  - 2024
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/13090
AB  - Nanoparticles (NPs), a distinct class of particles ranging in size from 1 to 100 nm, are one of the most promising technologies of the 21st century, and titanium dioxide NPs (TiO2 NPs) are among the most widely produced and used NPs globally. The increased application of TiO2 NPs raises concerns regarding their global safety and risks of exposure. Many animal studies have reported the accumulation of TiO2 NPs in female reproductive organs; however, evidence of the resultant toxicity remains ambiguous. Since the surface area and chemical modifications of NPs can significantly change their cytotoxicity, we aimed to compare the toxic effects of pristine TiO2 powder with surface-modified TiO2 powders with salicylic acid (TiO2/SA) and 5-aminosalicylic acid (TiO2/5-ASA) on the ovaries, oviducts, and uterus on the 14th day following acute oral treatment. The results, based on alterations in food and water intake, body mass, organ-to-body mass ratio, hormonal status, histological features of tissues of interest, and antioxidant parameters, suggest that the modification with 5-ASA can mitigate some of the observed toxic effects of TiO2 powder and encourage future investigations to create NPs that can potentially reduce the harmful effects of TiO2 NPs while preserving their positive impacts.
T2  - Antioxidants
T1  - Comparable Toxicity of Surface-Modified TiO2 Nanoparticles: An In Vivo Experimental Study on Reproductive Toxicity in Rats
VL  - 13
IS  - 2
SP  - 231
DO  - 10.3390/antiox13020231
ER  - 

@article{
author = "Todorović, Ana and Bobić, Katarina and Veljković, Filip and Pejić, Snežana and Glumac, Sofija and Stanković, Sanja and Milovanović, Tijana and Vukoje, Ivana and Nedeljković, Jovan and Radojević Škodrić, Sanja and Pajović, Snežana B. and Drakulić, Dunja",
year = "2024",
abstract = "Nanoparticles (NPs), a distinct class of particles ranging in size from 1 to 100 nm, are one of the most promising technologies of the 21st century, and titanium dioxide NPs (TiO2 NPs) are among the most widely produced and used NPs globally. The increased application of TiO2 NPs raises concerns regarding their global safety and risks of exposure. Many animal studies have reported the accumulation of TiO2 NPs in female reproductive organs; however, evidence of the resultant toxicity remains ambiguous. Since the surface area and chemical modifications of NPs can significantly change their cytotoxicity, we aimed to compare the toxic effects of pristine TiO2 powder with surface-modified TiO2 powders with salicylic acid (TiO2/SA) and 5-aminosalicylic acid (TiO2/5-ASA) on the ovaries, oviducts, and uterus on the 14th day following acute oral treatment. The results, based on alterations in food and water intake, body mass, organ-to-body mass ratio, hormonal status, histological features of tissues of interest, and antioxidant parameters, suggest that the modification with 5-ASA can mitigate some of the observed toxic effects of TiO2 powder and encourage future investigations to create NPs that can potentially reduce the harmful effects of TiO2 NPs while preserving their positive impacts.",
journal = "Antioxidants",
title = "Comparable Toxicity of Surface-Modified TiO2 Nanoparticles: An In Vivo Experimental Study on Reproductive Toxicity in Rats",
volume = "13",
number = "2",
pages = "231",
doi = "10.3390/antiox13020231"
}

Todorović, A., Bobić, K., Veljković, F., Pejić, S., Glumac, S., Stanković, S., Milovanović, T., Vukoje, I., Nedeljković, J., Radojević Škodrić, S., Pajović, S. B.,& Drakulić, D.. (2024). Comparable Toxicity of Surface-Modified TiO2 Nanoparticles: An In Vivo Experimental Study on Reproductive Toxicity in Rats. in Antioxidants, 13(2), 231.
https://doi.org/10.3390/antiox13020231

Todorović A, Bobić K, Veljković F, Pejić S, Glumac S, Stanković S, Milovanović T, Vukoje I, Nedeljković J, Radojević Škodrić S, Pajović SB, Drakulić D. Comparable Toxicity of Surface-Modified TiO2 Nanoparticles: An In Vivo Experimental Study on Reproductive Toxicity in Rats. in Antioxidants. 2024;13(2):231.
doi:10.3390/antiox13020231 .

Todorović, Ana, Bobić, Katarina, Veljković, Filip, Pejić, Snežana, Glumac, Sofija, Stanković, Sanja, Milovanović, Tijana, Vukoje, Ivana, Nedeljković, Jovan, Radojević Škodrić, Sanja, Pajović, Snežana B., Drakulić, Dunja, "Comparable Toxicity of Surface-Modified TiO2 Nanoparticles: An In Vivo Experimental Study on Reproductive Toxicity in Rats" in Antioxidants, 13, no. 2 (2024):231,
https://doi.org/10.3390/antiox13020231 . .

TY  - JOUR
AU  - Ilić Božović, Anja
AU  - Đoković, Petar
AU  - Milanović, Zorana
AU  - Janjić, Filip
AU  - Spariosu, Kristina
AU  - Radonjić, Vladimir
AU  - Radaković, Milena
AU  - Magaš, Vladimir
AU  - Filipović, Dimitrije
AU  - Stanković, Sanja
AU  - Kovačević Filipović, Milica
AU  - Beletić, Anđelo
PY  - 2023
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/13096
AB  - Homocysteine (Hcy) was investigated as the biomarker of cardiac, renal, and gastrointestinal disordersin dogs. Data about low Hcy concentrations in the systemic inflammatory response syndrome raised a hypothesis thatHcy in dogs could be a negative acute-phase reactant. This survey compared Hcy concentrations, serum amyloid A(SAA), and the routine laboratory parameters between healthy (HD, N=6) and dogs with inflammation of differentextent: mild (dirofilariosis (DIR), N=31), moderate (babesiosis (BAB), N=12), and severe (pyometra (PYO), N=8).The BAB and PYO groups had lower Hcy er than HD. Also, the levels in the PYO group were below those in theDIRO group. SAA had the inverse pattern. Across the groups, Hcy and SAA levels correlated negatively (ρ = -0.502,P<0.001). Hcy and SAA correlated with the erythrocyte count, hematocrit, hemoglobin and mean cellular hemoglobinconcentrations, and neutrophil count, with correlations being positive for Hcy and negative for SAA. Among all dogs,hemoglobin was the only independent predictor of Hcy concentration. Hcy levels in canine infections, decreased asacute-phase reaction (APR) intensified. Also, they were related with the hematology changes accompanying the APR.Further studies will establish the clinical potential of these alterations.
T2  - Journal of the Hellenic Veterinary Medical Society
T1  - Could homocysteine represent a negative acute phase reactant in canine infections-a pilot study?
VL  - 74
IS  - 1
SP  - 5463
EP  - 5470
DO  - 10.12681/jhvms.29529
ER  - 

@article{
author = "Ilić Božović, Anja and Đoković, Petar and Milanović, Zorana and Janjić, Filip and Spariosu, Kristina and Radonjić, Vladimir and Radaković, Milena and Magaš, Vladimir and Filipović, Dimitrije and Stanković, Sanja and Kovačević Filipović, Milica and Beletić, Anđelo",
year = "2023",
abstract = "Homocysteine (Hcy) was investigated as the biomarker of cardiac, renal, and gastrointestinal disordersin dogs. Data about low Hcy concentrations in the systemic inflammatory response syndrome raised a hypothesis thatHcy in dogs could be a negative acute-phase reactant. This survey compared Hcy concentrations, serum amyloid A(SAA), and the routine laboratory parameters between healthy (HD, N=6) and dogs with inflammation of differentextent: mild (dirofilariosis (DIR), N=31), moderate (babesiosis (BAB), N=12), and severe (pyometra (PYO), N=8).The BAB and PYO groups had lower Hcy er than HD. Also, the levels in the PYO group were below those in theDIRO group. SAA had the inverse pattern. Across the groups, Hcy and SAA levels correlated negatively (ρ = -0.502,P<0.001). Hcy and SAA correlated with the erythrocyte count, hematocrit, hemoglobin and mean cellular hemoglobinconcentrations, and neutrophil count, with correlations being positive for Hcy and negative for SAA. Among all dogs,hemoglobin was the only independent predictor of Hcy concentration. Hcy levels in canine infections, decreased asacute-phase reaction (APR) intensified. Also, they were related with the hematology changes accompanying the APR.Further studies will establish the clinical potential of these alterations.",
journal = "Journal of the Hellenic Veterinary Medical Society",
title = "Could homocysteine represent a negative acute phase reactant in canine infections-a pilot study?",
volume = "74",
number = "1",
pages = "5463-5470",
doi = "10.12681/jhvms.29529"
}

Ilić Božović, A., Đoković, P., Milanović, Z., Janjić, F., Spariosu, K., Radonjić, V., Radaković, M., Magaš, V., Filipović, D., Stanković, S., Kovačević Filipović, M.,& Beletić, A.. (2023). Could homocysteine represent a negative acute phase reactant in canine infections-a pilot study?. in Journal of the Hellenic Veterinary Medical Society, 74(1), 5463-5470.
https://doi.org/10.12681/jhvms.29529

Ilić Božović A, Đoković P, Milanović Z, Janjić F, Spariosu K, Radonjić V, Radaković M, Magaš V, Filipović D, Stanković S, Kovačević Filipović M, Beletić A. Could homocysteine represent a negative acute phase reactant in canine infections-a pilot study?. in Journal of the Hellenic Veterinary Medical Society. 2023;74(1):5463-5470.
doi:10.12681/jhvms.29529 .

Ilić Božović, Anja, Đoković, Petar, Milanović, Zorana, Janjić, Filip, Spariosu, Kristina, Radonjić, Vladimir, Radaković, Milena, Magaš, Vladimir, Filipović, Dimitrije, Stanković, Sanja, Kovačević Filipović, Milica, Beletić, Anđelo, "Could homocysteine represent a negative acute phase reactant in canine infections-a pilot study?" in Journal of the Hellenic Veterinary Medical Society, 74, no. 1 (2023):5463-5470,
https://doi.org/10.12681/jhvms.29529 . .

TY  - JOUR
AU  - Grigorov, Ilijana
AU  - Pejić, Snežana
AU  - Todorović, Ana
AU  - Drakulić, Dunja
AU  - Veljković, Filip
AU  - Miletić Vukajlović, Jadranka
AU  - Bobić, Katarina
AU  - Soldatović, Ivan
AU  - Đurašević, Siniša
AU  - Jasnić, Nebojša
AU  - Stanković, Sanja
AU  - Glumac, Sofija
AU  - Mihailović-Vučinić, Violeta
AU  - Milenković, Branislava
PY  - 2023
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/11550
AB  - The careful monitoring of patients with mild/moderate COVID-19 is of particular importance because of the rapid progression of complications associated with COVID-19. For prognostic reasons and for the economic management of health care resources, additional biomarkers need to be identified, and their monitoring can conceivably be performed in the early stages of the disease. In this retrospective cross-sectional study, we found that serum concentrations of high-mobility group box 1 (HMGB1) and heme oxygenase-1 (HO-1), at the time of hospital admission, could be useful biomarkers for COVID-19 management. The study included 160 randomly selected recovered patients with mild to moderate COVID-19 on admission. Compared with healthy controls, serum HMGB1 and HO-1 levels increased by 487.6 pg/mL versus 43.1 pg/mL and 1497.7 pg/mL versus 756.1 pg/mL, respectively. Serum HO-1 correlated significantly with serum HMGB1, oxidative stress parameters (malondialdehyde (MDA), the phosphatidylcholine/lysophosphatidylcholine ratio (PC/LPC), the ratio of reduced and oxidative glutathione (GSH/GSSG)), and anti-inflammatory acute phase proteins (ferritin, haptoglobin). Increased heme catabolism/hemolysis were not detected. We hypothesize that the increase in HO-1 in the early phase of COVID-19 disease is likely to have a survival benefit by providing protection against oxidative stress and inflammation, whereas the level of HMGB1 increase reflects the activity of the innate immune system and represents levels within which the disease can be kept under control.
T2  - International Journal of Molecular Sciences
T1  - Serum High-Mobility Group Box 1 and Heme Oxygenase-1 as Biomarkers in COVID-19 Patients at Hospital Admission
VL  - 24
IS  - 17
SP  - 13164
DO  - 10.3390/ijms241713164
ER  - 

@article{
author = "Grigorov, Ilijana and Pejić, Snežana and Todorović, Ana and Drakulić, Dunja and Veljković, Filip and Miletić Vukajlović, Jadranka and Bobić, Katarina and Soldatović, Ivan and Đurašević, Siniša and Jasnić, Nebojša and Stanković, Sanja and Glumac, Sofija and Mihailović-Vučinić, Violeta and Milenković, Branislava",
year = "2023",
abstract = "The careful monitoring of patients with mild/moderate COVID-19 is of particular importance because of the rapid progression of complications associated with COVID-19. For prognostic reasons and for the economic management of health care resources, additional biomarkers need to be identified, and their monitoring can conceivably be performed in the early stages of the disease. In this retrospective cross-sectional study, we found that serum concentrations of high-mobility group box 1 (HMGB1) and heme oxygenase-1 (HO-1), at the time of hospital admission, could be useful biomarkers for COVID-19 management. The study included 160 randomly selected recovered patients with mild to moderate COVID-19 on admission. Compared with healthy controls, serum HMGB1 and HO-1 levels increased by 487.6 pg/mL versus 43.1 pg/mL and 1497.7 pg/mL versus 756.1 pg/mL, respectively. Serum HO-1 correlated significantly with serum HMGB1, oxidative stress parameters (malondialdehyde (MDA), the phosphatidylcholine/lysophosphatidylcholine ratio (PC/LPC), the ratio of reduced and oxidative glutathione (GSH/GSSG)), and anti-inflammatory acute phase proteins (ferritin, haptoglobin). Increased heme catabolism/hemolysis were not detected. We hypothesize that the increase in HO-1 in the early phase of COVID-19 disease is likely to have a survival benefit by providing protection against oxidative stress and inflammation, whereas the level of HMGB1 increase reflects the activity of the innate immune system and represents levels within which the disease can be kept under control.",
journal = "International Journal of Molecular Sciences",
title = "Serum High-Mobility Group Box 1 and Heme Oxygenase-1 as Biomarkers in COVID-19 Patients at Hospital Admission",
volume = "24",
number = "17",
pages = "13164",
doi = "10.3390/ijms241713164"
}

Grigorov, I., Pejić, S., Todorović, A., Drakulić, D., Veljković, F., Miletić Vukajlović, J., Bobić, K., Soldatović, I., Đurašević, S., Jasnić, N., Stanković, S., Glumac, S., Mihailović-Vučinić, V.,& Milenković, B.. (2023). Serum High-Mobility Group Box 1 and Heme Oxygenase-1 as Biomarkers in COVID-19 Patients at Hospital Admission. in International Journal of Molecular Sciences, 24(17), 13164.
https://doi.org/10.3390/ijms241713164

Grigorov I, Pejić S, Todorović A, Drakulić D, Veljković F, Miletić Vukajlović J, Bobić K, Soldatović I, Đurašević S, Jasnić N, Stanković S, Glumac S, Mihailović-Vučinić V, Milenković B. Serum High-Mobility Group Box 1 and Heme Oxygenase-1 as Biomarkers in COVID-19 Patients at Hospital Admission. in International Journal of Molecular Sciences. 2023;24(17):13164.
doi:10.3390/ijms241713164 .

Grigorov, Ilijana, Pejić, Snežana, Todorović, Ana, Drakulić, Dunja, Veljković, Filip, Miletić Vukajlović, Jadranka, Bobić, Katarina, Soldatović, Ivan, Đurašević, Siniša, Jasnić, Nebojša, Stanković, Sanja, Glumac, Sofija, Mihailović-Vučinić, Violeta, Milenković, Branislava, "Serum High-Mobility Group Box 1 and Heme Oxygenase-1 as Biomarkers in COVID-19 Patients at Hospital Admission" in International Journal of Molecular Sciences, 24, no. 17 (2023):13164,
https://doi.org/10.3390/ijms241713164 . .

TY  - CONF
AU  - Todorović, Ana
AU  - Pejić, Snežana
AU  - Bobić, Katarina
AU  - Milovanović, Tijana
AU  - Stanković, Sanja
AU  - Drakulić, Dunja
PY  - 2022
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/12742
AB  - Titanium dioxide nanoparticles (TiO2 NPs) are commonly used in various industrial and consumer products, including cosmetics, pharmaceuticals, food and beverages, etc. Since bare TiO2 NPs pose a risk to reproductive health, we compared their toxic effect to effect of TiO2 NPs surface-modified with salicylic acid (TiO2/SA NPs) or 5-amino salicylic acid (TiO2/5-ASA NPs) in female rats 14 days after acute oral treatment. In rat ovaries, oviducts, and uterus, bare TiO2 NPs and TiO2/SA NPs promoted acute toxicity along with the hormonal imbalance, irregular estrous cycle, swelling of the genital organs that increased organ-to-body mass ratio accompanied with prooxidative shift in redox status. The observed effects were less pronounced in TiO2/5-ASA NPs-treated rats. According to the presented results, surface-binding of 5-ASA, but not SA are able to suppress the toxic effects of bare TiO2 NPs in rat female reproductive system. Further studies are necessary to confirm these assumptions.
PB  - Belgrade : Society of Physical Chemists of Serbia
C3  - PHYSICAL CHEMISTRY 2022 : 16th International Conference on Fundamental and Applied Aspects of Physical Chemistry : Book of abstracts
T1  - Acute oral intake of surface-modified TiO2 nanoparticles promotes biochemical and morphological changes in rat female reproductive system
SP  - 73
EP  - 73
UR  - https://hdl.handle.net/21.15107/rcub_vinar_12742
ER  - 

@conference{
author = "Todorović, Ana and Pejić, Snežana and Bobić, Katarina and Milovanović, Tijana and Stanković, Sanja and Drakulić, Dunja",
year = "2022",
abstract = "Titanium dioxide nanoparticles (TiO2 NPs) are commonly used in various industrial and consumer products, including cosmetics, pharmaceuticals, food and beverages, etc. Since bare TiO2 NPs pose a risk to reproductive health, we compared their toxic effect to effect of TiO2 NPs surface-modified with salicylic acid (TiO2/SA NPs) or 5-amino salicylic acid (TiO2/5-ASA NPs) in female rats 14 days after acute oral treatment. In rat ovaries, oviducts, and uterus, bare TiO2 NPs and TiO2/SA NPs promoted acute toxicity along with the hormonal imbalance, irregular estrous cycle, swelling of the genital organs that increased organ-to-body mass ratio accompanied with prooxidative shift in redox status. The observed effects were less pronounced in TiO2/5-ASA NPs-treated rats. According to the presented results, surface-binding of 5-ASA, but not SA are able to suppress the toxic effects of bare TiO2 NPs in rat female reproductive system. Further studies are necessary to confirm these assumptions.",
publisher = "Belgrade : Society of Physical Chemists of Serbia",
journal = "PHYSICAL CHEMISTRY 2022 : 16th International Conference on Fundamental and Applied Aspects of Physical Chemistry : Book of abstracts",
title = "Acute oral intake of surface-modified TiO2 nanoparticles promotes biochemical and morphological changes in rat female reproductive system",
pages = "73-73",
url = "https://hdl.handle.net/21.15107/rcub_vinar_12742"
}

Todorović, A., Pejić, S., Bobić, K., Milovanović, T., Stanković, S.,& Drakulić, D.. (2022). Acute oral intake of surface-modified TiO2 nanoparticles promotes biochemical and morphological changes in rat female reproductive system. in PHYSICAL CHEMISTRY 2022 : 16th International Conference on Fundamental and Applied Aspects of Physical Chemistry : Book of abstracts
Belgrade : Society of Physical Chemists of Serbia., 73-73.
https://hdl.handle.net/21.15107/rcub_vinar_12742

Todorović A, Pejić S, Bobić K, Milovanović T, Stanković S, Drakulić D. Acute oral intake of surface-modified TiO2 nanoparticles promotes biochemical and morphological changes in rat female reproductive system. in PHYSICAL CHEMISTRY 2022 : 16th International Conference on Fundamental and Applied Aspects of Physical Chemistry : Book of abstracts. 2022;:73-73.
https://hdl.handle.net/21.15107/rcub_vinar_12742 .

Todorović, Ana, Pejić, Snežana, Bobić, Katarina, Milovanović, Tijana, Stanković, Sanja, Drakulić, Dunja, "Acute oral intake of surface-modified TiO2 nanoparticles promotes biochemical and morphological changes in rat female reproductive system" in PHYSICAL CHEMISTRY 2022 : 16th International Conference on Fundamental and Applied Aspects of Physical Chemistry : Book of abstracts (2022):73-73,
https://hdl.handle.net/21.15107/rcub_vinar_12742 .

TY  - JOUR
AU  - Đurašević, Siniša
AU  - Ružičić, Aleksandra
AU  - Lakić, Iva
AU  - Tosti, Tomislav
AU  - Đurović, Saša
AU  - Glumac, Sofija
AU  - Pejić, Snežana
AU  - Todorović, Ana
AU  - Drakulić, Dunja R.
AU  - Stanković, Sanja
AU  - Jasnić, Nebojša
AU  - Đorđević, Jelena
AU  - Todorović, Zoran
PY  - 2022
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10173
AB  - A dysregulated and overwhelming response to an infection accompanied by the exaggerated pro-inflammatory state and metabolism disturbance leads to the fatal outcome in sepsis. Previously we showed that meldonium, an anti-ischemic drug clinically used to treat myocardial and cerebral ischemia, strongly increases mortality in faecal-induced peritonitis (FIP) in rats. We postulated that the same mechanism that is responsible for the otherwise strong anti-inflammatory effects of meldonium could be the culprit of the increased mortality. In the present study, we applied the LPS-induced model of sepsis to explore the presence of any differences from and/or similarities to the FIP model. When it comes to energy production, despite some shared similarities, it is evident that LPS and FIP models of sepsis differ greatly. A different profile of sympathoadrenal activation may account for this observation, as it was lacking in the FIP model, whereas in the LPS model it was strong enough to overcome the effects of meldonium. Therefore, choosing the appropriate model of sepsis induction is of great importance, especially if energy homeostasis is the main focus of the study. Even when differences in the experimental design of the two models are acknowledged, the role of different patterns of energy production cannot be excluded. On that account, our results draw attention to the importance of uninterrupted energy production in sepsis but also call for much-needed revisions of the current recommendations for its treatment.
T2  - International Journal of Molecular Sciences
T1  - The Effects of a Meldonium Pre-Treatment on the Course of the LPS-Induced Sepsis in Rats
VL  - 23
IS  - 4
SP  - 2395
DO  - 10.3390/ijms23042395
ER  - 

@article{
author = "Đurašević, Siniša and Ružičić, Aleksandra and Lakić, Iva and Tosti, Tomislav and Đurović, Saša and Glumac, Sofija and Pejić, Snežana and Todorović, Ana and Drakulić, Dunja R. and Stanković, Sanja and Jasnić, Nebojša and Đorđević, Jelena and Todorović, Zoran",
year = "2022",
abstract = "A dysregulated and overwhelming response to an infection accompanied by the exaggerated pro-inflammatory state and metabolism disturbance leads to the fatal outcome in sepsis. Previously we showed that meldonium, an anti-ischemic drug clinically used to treat myocardial and cerebral ischemia, strongly increases mortality in faecal-induced peritonitis (FIP) in rats. We postulated that the same mechanism that is responsible for the otherwise strong anti-inflammatory effects of meldonium could be the culprit of the increased mortality. In the present study, we applied the LPS-induced model of sepsis to explore the presence of any differences from and/or similarities to the FIP model. When it comes to energy production, despite some shared similarities, it is evident that LPS and FIP models of sepsis differ greatly. A different profile of sympathoadrenal activation may account for this observation, as it was lacking in the FIP model, whereas in the LPS model it was strong enough to overcome the effects of meldonium. Therefore, choosing the appropriate model of sepsis induction is of great importance, especially if energy homeostasis is the main focus of the study. Even when differences in the experimental design of the two models are acknowledged, the role of different patterns of energy production cannot be excluded. On that account, our results draw attention to the importance of uninterrupted energy production in sepsis but also call for much-needed revisions of the current recommendations for its treatment.",
journal = "International Journal of Molecular Sciences",
title = "The Effects of a Meldonium Pre-Treatment on the Course of the LPS-Induced Sepsis in Rats",
volume = "23",
number = "4",
pages = "2395",
doi = "10.3390/ijms23042395"
}

Đurašević, S., Ružičić, A., Lakić, I., Tosti, T., Đurović, S., Glumac, S., Pejić, S., Todorović, A., Drakulić, D. R., Stanković, S., Jasnić, N., Đorđević, J.,& Todorović, Z.. (2022). The Effects of a Meldonium Pre-Treatment on the Course of the LPS-Induced Sepsis in Rats. in International Journal of Molecular Sciences, 23(4), 2395.
https://doi.org/10.3390/ijms23042395

Đurašević S, Ružičić A, Lakić I, Tosti T, Đurović S, Glumac S, Pejić S, Todorović A, Drakulić DR, Stanković S, Jasnić N, Đorđević J, Todorović Z. The Effects of a Meldonium Pre-Treatment on the Course of the LPS-Induced Sepsis in Rats. in International Journal of Molecular Sciences. 2022;23(4):2395.
doi:10.3390/ijms23042395 .

Đurašević, Siniša, Ružičić, Aleksandra, Lakić, Iva, Tosti, Tomislav, Đurović, Saša, Glumac, Sofija, Pejić, Snežana, Todorović, Ana, Drakulić, Dunja R., Stanković, Sanja, Jasnić, Nebojša, Đorđević, Jelena, Todorović, Zoran, "The Effects of a Meldonium Pre-Treatment on the Course of the LPS-Induced Sepsis in Rats" in International Journal of Molecular Sciences, 23, no. 4 (2022):2395,
https://doi.org/10.3390/ijms23042395 . .

TY  - JOUR
AU  - Pantić, Igor
AU  - Paunović, Jovana
AU  - Pejić, Snežana
AU  - Drakulić, Dunja R.
AU  - Todorović, Ana
AU  - Stanković, Sanja
AU  - Vučević, Danijela
AU  - Cumic, Jelena
AU  - Radosavljević, Tatjana
PY  - 2022
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10212
AB  - Artificial intelligence (AI) and machine learning models are today frequently used for classification and prediction of various biochemical processes and phenomena. In recent years, numerous research efforts have been focused on developing such models for assessment, categorization, and prediction of oxidative stress. Supervised machine learning can successfully automate the process of evaluation and quantification of oxidative damage in biological samples, as well as extract useful data from the abundance of experimental results. In this concise review, we cover the possible applications of neural networks, decision trees and regression analysis as three common strategies in machine learning. We also review recent works on the various weaknesses and limitations of artificial intelligence in biochemistry and related scientific areas. Finally, we discuss future innovative approaches on the ways how AI can contribute to the automation of oxidative stress measurement and diagnosis of diseases associated with oxidative damage.
T2  - Chemico-Biological Interactions
T2  - Chemico-Biological Interactions
T1  - Artificial intelligence approaches to the biochemistry of oxidative stress: Current state of the art
VL  - 358
SP  - 109888
DO  - 10.1016/j.cbi.2022.109888
ER  - 

@article{
author = "Pantić, Igor and Paunović, Jovana and Pejić, Snežana and Drakulić, Dunja R. and Todorović, Ana and Stanković, Sanja and Vučević, Danijela and Cumic, Jelena and Radosavljević, Tatjana",
year = "2022",
abstract = "Artificial intelligence (AI) and machine learning models are today frequently used for classification and prediction of various biochemical processes and phenomena. In recent years, numerous research efforts have been focused on developing such models for assessment, categorization, and prediction of oxidative stress. Supervised machine learning can successfully automate the process of evaluation and quantification of oxidative damage in biological samples, as well as extract useful data from the abundance of experimental results. In this concise review, we cover the possible applications of neural networks, decision trees and regression analysis as three common strategies in machine learning. We also review recent works on the various weaknesses and limitations of artificial intelligence in biochemistry and related scientific areas. Finally, we discuss future innovative approaches on the ways how AI can contribute to the automation of oxidative stress measurement and diagnosis of diseases associated with oxidative damage.",
journal = "Chemico-Biological Interactions, Chemico-Biological Interactions",
title = "Artificial intelligence approaches to the biochemistry of oxidative stress: Current state of the art",
volume = "358",
pages = "109888",
doi = "10.1016/j.cbi.2022.109888"
}

Pantić, I., Paunović, J., Pejić, S., Drakulić, D. R., Todorović, A., Stanković, S., Vučević, D., Cumic, J.,& Radosavljević, T.. (2022). Artificial intelligence approaches to the biochemistry of oxidative stress: Current state of the art. in Chemico-Biological Interactions, 358, 109888.
https://doi.org/10.1016/j.cbi.2022.109888

Pantić I, Paunović J, Pejić S, Drakulić DR, Todorović A, Stanković S, Vučević D, Cumic J, Radosavljević T. Artificial intelligence approaches to the biochemistry of oxidative stress: Current state of the art. in Chemico-Biological Interactions. 2022;358:109888.
doi:10.1016/j.cbi.2022.109888 .

Pantić, Igor, Paunović, Jovana, Pejić, Snežana, Drakulić, Dunja R., Todorović, Ana, Stanković, Sanja, Vučević, Danijela, Cumic, Jelena, Radosavljević, Tatjana, "Artificial intelligence approaches to the biochemistry of oxidative stress: Current state of the art" in Chemico-Biological Interactions, 358 (2022):109888,
https://doi.org/10.1016/j.cbi.2022.109888 . .

TY  - JOUR
AU  - Kornjača, Duško
AU  - Živković, Vladimir I.
AU  - Krstić, Danijela Z.
AU  - Čolović, Mirjana B.
AU  - Đurić, Marko
AU  - Stanković, Sanja
AU  - Mutavdžin, Slavica
AU  - Jakovljević, Vladimir Lj.
AU  - Đurić, Dragan M.
PY  - 2018
UR  - http://www.doiserbia.nb.rs/Article.aspx?ID=0354-46641700041K
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/7714
AB  - The aim of this study was to assess the effects of DL-homocysteine (DL-Hcy) and DL-homocysteine thiolactone (DL-Hcy TLHC) on selected serum biochemical parameters, markers of oxidative stress and the activities of antioxidant enzymes (catalase (CAT), glutathione peroxidase (GPx), superoxide dismutase (SOD)) in the plasma, as well as on acetylcholinesterase (AChE) activity in the cardiac tissue homogenate in the rat. Male Wistar rats were divided into three groups as follows: control group (1 mL 0.9% NaCl, intraperitoneal (i.p.) injection), DL-Hcy group (8 mmol/kg body mass (b.m.), i.p.) or DL-Hcy TLHC group (8 mmol/kg b.m., i.p.). One hour after administration, the rats were euthanized, whole blood was collected for biochemical analysis, and the heart was excised. Following the i.p. administration of DL-Hcy and DL-Hcy TLHC, the activities of antioxidant enzymes were mostly significantly increased, while plasma malondialdehyde (MDA) was decreased. Administration of DL-Hcy and DL-Hcy TLHC significantly inhibited AChE activity in rat cardiac tissue. Our findings suggest that DL-Hcy and DL-Hcy TLHC exerted prooxidant effects; however, the decrease in MDA points to an inverse response to the increase in antioxidant enzyme activities. While both substances inhibited AChE activity in rat cardiac tissue, DL-Hcy TLHC induced stronger effects than DL-Hcy.
T2  - Archives of Biological Sciences
T1  - The effects of acute hyperhomocysteinemia induced by DL-homocysteine or DL-homocysteine thiolactone on serum biochemical parameters, plasma antioxidant enzyme and cardiac acetylcholinesterase activities in the rat
VL  - 70
IS  - 2
SP  - 241
EP  - 248
DO  - 10.2298/ABS170731041K
ER  - 

@article{
author = "Kornjača, Duško and Živković, Vladimir I. and Krstić, Danijela Z. and Čolović, Mirjana B. and Đurić, Marko and Stanković, Sanja and Mutavdžin, Slavica and Jakovljević, Vladimir Lj. and Đurić, Dragan M.",
year = "2018",
abstract = "The aim of this study was to assess the effects of DL-homocysteine (DL-Hcy) and DL-homocysteine thiolactone (DL-Hcy TLHC) on selected serum biochemical parameters, markers of oxidative stress and the activities of antioxidant enzymes (catalase (CAT), glutathione peroxidase (GPx), superoxide dismutase (SOD)) in the plasma, as well as on acetylcholinesterase (AChE) activity in the cardiac tissue homogenate in the rat. Male Wistar rats were divided into three groups as follows: control group (1 mL 0.9% NaCl, intraperitoneal (i.p.) injection), DL-Hcy group (8 mmol/kg body mass (b.m.), i.p.) or DL-Hcy TLHC group (8 mmol/kg b.m., i.p.). One hour after administration, the rats were euthanized, whole blood was collected for biochemical analysis, and the heart was excised. Following the i.p. administration of DL-Hcy and DL-Hcy TLHC, the activities of antioxidant enzymes were mostly significantly increased, while plasma malondialdehyde (MDA) was decreased. Administration of DL-Hcy and DL-Hcy TLHC significantly inhibited AChE activity in rat cardiac tissue. Our findings suggest that DL-Hcy and DL-Hcy TLHC exerted prooxidant effects; however, the decrease in MDA points to an inverse response to the increase in antioxidant enzyme activities. While both substances inhibited AChE activity in rat cardiac tissue, DL-Hcy TLHC induced stronger effects than DL-Hcy.",
journal = "Archives of Biological Sciences",
title = "The effects of acute hyperhomocysteinemia induced by DL-homocysteine or DL-homocysteine thiolactone on serum biochemical parameters, plasma antioxidant enzyme and cardiac acetylcholinesterase activities in the rat",
volume = "70",
number = "2",
pages = "241-248",
doi = "10.2298/ABS170731041K"
}

Kornjača, D., Živković, V. I., Krstić, D. Z., Čolović, M. B., Đurić, M., Stanković, S., Mutavdžin, S., Jakovljević, V. Lj.,& Đurić, D. M.. (2018). The effects of acute hyperhomocysteinemia induced by DL-homocysteine or DL-homocysteine thiolactone on serum biochemical parameters, plasma antioxidant enzyme and cardiac acetylcholinesterase activities in the rat. in Archives of Biological Sciences, 70(2), 241-248.
https://doi.org/10.2298/ABS170731041K

Kornjača D, Živković VI, Krstić DZ, Čolović MB, Đurić M, Stanković S, Mutavdžin S, Jakovljević VL, Đurić DM. The effects of acute hyperhomocysteinemia induced by DL-homocysteine or DL-homocysteine thiolactone on serum biochemical parameters, plasma antioxidant enzyme and cardiac acetylcholinesterase activities in the rat. in Archives of Biological Sciences. 2018;70(2):241-248.
doi:10.2298/ABS170731041K .

Kornjača, Duško, Živković, Vladimir I., Krstić, Danijela Z., Čolović, Mirjana B., Đurić, Marko, Stanković, Sanja, Mutavdžin, Slavica, Jakovljević, Vladimir Lj., Đurić, Dragan M., "The effects of acute hyperhomocysteinemia induced by DL-homocysteine or DL-homocysteine thiolactone on serum biochemical parameters, plasma antioxidant enzyme and cardiac acetylcholinesterase activities in the rat" in Archives of Biological Sciences, 70, no. 2 (2018):241-248,
https://doi.org/10.2298/ABS170731041K . .

TY  - JOUR
AU  - Stanković, Sanja
AU  - Alavantić, Dragan
AU  - Majkic-Singh, Nada
PY  - 2009
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/6839
AB  - Microplate array diagonal gel electrophoresis (MADGE) was invented for molecular genetic epidemiological studies. MADGE is a highly flexible, cost effective, microplate compatible solution to high throughput electrophoresis needs. It enables several thousands to million gel lines per day for direct assay of single-base variation in different capacity laboratories. Variants of the standard 96-well MADGE include: 96-well stretch-MADGE, 192-well MADGE, 384-well MADGE, and 768-well MADGE. Melt-MADGE combines the temporal thermal ramp apparatus to achieve similar throughput for de novo mutation scanning. Basic MADGE principles and procedures, preparation of MADGE gels, electrophoresis, visualization and analysis of these gels, as well as modifications of the basic 96-well MADGE will be discussed in detail. For the first time in our country, this revolutionary polyacrylamid electrophoresis was done in 1998. We shortly review our studies which used MADGE for high throughput genotyping of the apolipoprotein E. MADGE and melt-MADGE will have an important role in the future genetic research of complex diseases and especially in pharmacogenomics.
T2  - Journal of Medical Biochemistry
T1  - Madge - Microplate Array Diagonal Gel Electrophoresis
VL  - 28
IS  - 4
SP  - 235
EP  - 240
DO  - 10.2478/v10011-009-0030-y
ER  - 

@article{
author = "Stanković, Sanja and Alavantić, Dragan and Majkic-Singh, Nada",
year = "2009",
abstract = "Microplate array diagonal gel electrophoresis (MADGE) was invented for molecular genetic epidemiological studies. MADGE is a highly flexible, cost effective, microplate compatible solution to high throughput electrophoresis needs. It enables several thousands to million gel lines per day for direct assay of single-base variation in different capacity laboratories. Variants of the standard 96-well MADGE include: 96-well stretch-MADGE, 192-well MADGE, 384-well MADGE, and 768-well MADGE. Melt-MADGE combines the temporal thermal ramp apparatus to achieve similar throughput for de novo mutation scanning. Basic MADGE principles and procedures, preparation of MADGE gels, electrophoresis, visualization and analysis of these gels, as well as modifications of the basic 96-well MADGE will be discussed in detail. For the first time in our country, this revolutionary polyacrylamid electrophoresis was done in 1998. We shortly review our studies which used MADGE for high throughput genotyping of the apolipoprotein E. MADGE and melt-MADGE will have an important role in the future genetic research of complex diseases and especially in pharmacogenomics.",
journal = "Journal of Medical Biochemistry",
title = "Madge - Microplate Array Diagonal Gel Electrophoresis",
volume = "28",
number = "4",
pages = "235-240",
doi = "10.2478/v10011-009-0030-y"
}

Stanković, S., Alavantić, D.,& Majkic-Singh, N.. (2009). Madge - Microplate Array Diagonal Gel Electrophoresis. in Journal of Medical Biochemistry, 28(4), 235-240.
https://doi.org/10.2478/v10011-009-0030-y

Stanković S, Alavantić D, Majkic-Singh N. Madge - Microplate Array Diagonal Gel Electrophoresis. in Journal of Medical Biochemistry. 2009;28(4):235-240.
doi:10.2478/v10011-009-0030-y .

Stanković, Sanja, Alavantić, Dragan, Majkic-Singh, Nada, "Madge - Microplate Array Diagonal Gel Electrophoresis" in Journal of Medical Biochemistry, 28, no. 4 (2009):235-240,
https://doi.org/10.2478/v10011-009-0030-y . .

TY  - JOUR
AU  - Stanković, Aleksandra
AU  - Stanković, Sanja
AU  - Jovanovic-Markovic, Zagorka
AU  - Živković, Maja
AU  - Đurić, Tamara
AU  - Glišić, Sanja
AU  - Alavantić, Dragan
PY  - 2007
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/3419
AB  - The plasma concentration of apoB has recently been reported to be the best lipid predictor of coronary heart disease. The possible associations of genetic markers in the apolipoprotein B gene (Xbal, EcoRI, MspI, Ins/Del, and 4311 A/G polymorphisms) were evaluated in patients with ischemic cerebrovascular disease (ICVD) and controls of equivalent BMI. The odds ratio for ICVD in the X+X+ genotype was 2.22, 95% CI 1.24-3.96 (P LT 0.05), while that for ICVD in the Ins/Ins genotype was 2.82, 95% CI 1.57-5.06 (P LT 0.05). The patients had significantly higher frequency of the 4311 A allele compared to the controls (P LT 0.01). Our results support the assumption that apoB gene polymorphisms may contribute to the extent of cerebrovascular disease risk.
T2  - Archives of Biological Sciences
T1  - Apolipoprotein B gene polymorphisms in patients from Serbia with ischemic cerebrovascular disease
VL  - 59
IS  - 4
SP  - 303
EP  - 309
DO  - 10.2298/ABS0704303S
ER  - 

@article{
author = "Stanković, Aleksandra and Stanković, Sanja and Jovanovic-Markovic, Zagorka and Živković, Maja and Đurić, Tamara and Glišić, Sanja and Alavantić, Dragan",
year = "2007",
abstract = "The plasma concentration of apoB has recently been reported to be the best lipid predictor of coronary heart disease. The possible associations of genetic markers in the apolipoprotein B gene (Xbal, EcoRI, MspI, Ins/Del, and 4311 A/G polymorphisms) were evaluated in patients with ischemic cerebrovascular disease (ICVD) and controls of equivalent BMI. The odds ratio for ICVD in the X+X+ genotype was 2.22, 95% CI 1.24-3.96 (P LT 0.05), while that for ICVD in the Ins/Ins genotype was 2.82, 95% CI 1.57-5.06 (P LT 0.05). The patients had significantly higher frequency of the 4311 A allele compared to the controls (P LT 0.01). Our results support the assumption that apoB gene polymorphisms may contribute to the extent of cerebrovascular disease risk.",
journal = "Archives of Biological Sciences",
title = "Apolipoprotein B gene polymorphisms in patients from Serbia with ischemic cerebrovascular disease",
volume = "59",
number = "4",
pages = "303-309",
doi = "10.2298/ABS0704303S"
}

Stanković, A., Stanković, S., Jovanovic-Markovic, Z., Živković, M., Đurić, T., Glišić, S.,& Alavantić, D.. (2007). Apolipoprotein B gene polymorphisms in patients from Serbia with ischemic cerebrovascular disease. in Archives of Biological Sciences, 59(4), 303-309.
https://doi.org/10.2298/ABS0704303S

Stanković A, Stanković S, Jovanovic-Markovic Z, Živković M, Đurić T, Glišić S, Alavantić D. Apolipoprotein B gene polymorphisms in patients from Serbia with ischemic cerebrovascular disease. in Archives of Biological Sciences. 2007;59(4):303-309.
doi:10.2298/ABS0704303S .

Stanković, Aleksandra, Stanković, Sanja, Jovanovic-Markovic, Zagorka, Živković, Maja, Đurić, Tamara, Glišić, Sanja, Alavantić, Dragan, "Apolipoprotein B gene polymorphisms in patients from Serbia with ischemic cerebrovascular disease" in Archives of Biological Sciences, 59, no. 4 (2007):303-309,
https://doi.org/10.2298/ABS0704303S . .

TY  - CONF
AU  - Stanković, Sanja
AU  - Glišić, Sanja
AU  - Majkic-Singh, N
AU  - Jovanovic-Markovic, Z
AU  - Alavantić, Dragan
PY  - 2005
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/6508
C3  - Clinical Chemistry
T1  - Apolipoprotein E and apolipoprotein B gene polymorphisms and risk for ischemic stroke
VL  - 51
SP  - A138
EP  - A138
UR  - https://hdl.handle.net/21.15107/rcub_vinar_6508
ER  - 

@conference{
author = "Stanković, Sanja and Glišić, Sanja and Majkic-Singh, N and Jovanovic-Markovic, Z and Alavantić, Dragan",
year = "2005",
journal = "Clinical Chemistry",
title = "Apolipoprotein E and apolipoprotein B gene polymorphisms and risk for ischemic stroke",
volume = "51",
pages = "A138-A138",
url = "https://hdl.handle.net/21.15107/rcub_vinar_6508"
}

Stanković, S., Glišić, S., Majkic-Singh, N., Jovanovic-Markovic, Z.,& Alavantić, D.. (2005). Apolipoprotein E and apolipoprotein B gene polymorphisms and risk for ischemic stroke. in Clinical Chemistry, 51, A138-A138.
https://hdl.handle.net/21.15107/rcub_vinar_6508

Stanković S, Glišić S, Majkic-Singh N, Jovanovic-Markovic Z, Alavantić D. Apolipoprotein E and apolipoprotein B gene polymorphisms and risk for ischemic stroke. in Clinical Chemistry. 2005;51:A138-A138.
https://hdl.handle.net/21.15107/rcub_vinar_6508 .

Stanković, Sanja, Glišić, Sanja, Majkic-Singh, N, Jovanovic-Markovic, Z, Alavantić, Dragan, "Apolipoprotein E and apolipoprotein B gene polymorphisms and risk for ischemic stroke" in Clinical Chemistry, 51 (2005):A138-A138,
https://hdl.handle.net/21.15107/rcub_vinar_6508 .

TY  - JOUR
AU  - Stanković, Sanja
AU  - Spasojević-Kalimanovska, Vesna
AU  - Alavantić, Dragan
PY  - 2000
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/2356
AB  - Apolipoprotein E (apoE) genotypes were determined in a subset of 591 subjects by restriction isotyping/MADGE analysis. The characterization of different apoE isoforms (133 subjects) has also been carried out by isoelectric focussing/immunoblotting of plasma. In men, levels of both total and low-density lipoprotein cholesterol among the three apoE genotype groups (E2, E3, E4) differed significantly (p LT 0.05). The E2 allele was associated with the lower both total and low-density lipoprotein cholesterol, where the E4 allele had the opposite effects. In women, no significant effect of apoE polymorphism on serum lipid levels was observed. These data could be taken into consideration in the future evaluation of the risk of cardiovascular and/or neurodegenerative diseases in Serbian population.
T2  - Jugoslovenska Medicinska Biohemija
T1  - Association of apoE polymorphism with serum lipids in Serbian healthy population
VL  - 19
IS  - 2
SP  - 115
EP  - 120
UR  - https://hdl.handle.net/21.15107/rcub_vinar_2356
ER  - 

@article{
author = "Stanković, Sanja and Spasojević-Kalimanovska, Vesna and Alavantić, Dragan",
year = "2000",
abstract = "Apolipoprotein E (apoE) genotypes were determined in a subset of 591 subjects by restriction isotyping/MADGE analysis. The characterization of different apoE isoforms (133 subjects) has also been carried out by isoelectric focussing/immunoblotting of plasma. In men, levels of both total and low-density lipoprotein cholesterol among the three apoE genotype groups (E2, E3, E4) differed significantly (p LT 0.05). The E2 allele was associated with the lower both total and low-density lipoprotein cholesterol, where the E4 allele had the opposite effects. In women, no significant effect of apoE polymorphism on serum lipid levels was observed. These data could be taken into consideration in the future evaluation of the risk of cardiovascular and/or neurodegenerative diseases in Serbian population.",
journal = "Jugoslovenska Medicinska Biohemija",
title = "Association of apoE polymorphism with serum lipids in Serbian healthy population",
volume = "19",
number = "2",
pages = "115-120",
url = "https://hdl.handle.net/21.15107/rcub_vinar_2356"
}

Stanković, S., Spasojević-Kalimanovska, V.,& Alavantić, D.. (2000). Association of apoE polymorphism with serum lipids in Serbian healthy population. in Jugoslovenska Medicinska Biohemija, 19(2), 115-120.
https://hdl.handle.net/21.15107/rcub_vinar_2356

Stanković S, Spasojević-Kalimanovska V, Alavantić D. Association of apoE polymorphism with serum lipids in Serbian healthy population. in Jugoslovenska Medicinska Biohemija. 2000;19(2):115-120.
https://hdl.handle.net/21.15107/rcub_vinar_2356 .

Stanković, Sanja, Spasojević-Kalimanovska, Vesna, Alavantić, Dragan, "Association of apoE polymorphism with serum lipids in Serbian healthy population" in Jugoslovenska Medicinska Biohemija, 19, no. 2 (2000):115-120,
https://hdl.handle.net/21.15107/rcub_vinar_2356 .

TY  - JOUR
AU  - Stanković, Sanja
AU  - Glišić, Sanja
AU  - Alavantić, Dragan
PY  - 2000
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/2378
AB  - To date, no data have been available on relationship between apolipoprotein E polymorphism and lipid levels in Serbian populations. Blood samples were obtained from 591 healthy normal individuals (193 women and 398 men). A 244 bp sequence of the apolipoprotein E gene including the two polymorphic sites was amplified by polymerase chain reaction. After digestion with Hhal, DNA fragments were visualized by microplate array diagonal gel electrophoresis. In men, levels of both total and low-density lipoprotein cholesterol among the three apolipoprotein E genotype groups differed significantly (p LT 0.05). The epsilon 2 allele was associated with lower concentrations of both total and low-density lipoprotein cholesterol, where the epsilon 4 allele had the opposite effects. No significant effects of apolipoprotein E polymorphism on serum lipid levels were observed in women. The presented data could be taken into consideration in any future disease risk evaluation in this population.
T2  - Clinical Chemistry and Laboratory Medicine
T1  - The effect of a gender difference in the apolipoprotein E gene DNA polymorphism on serum lipid levels in a Serbian healthy population
VL  - 38
IS  - 6
SP  - 539
EP  - 544
DO  - 10.1515/CCLM.2000.079
ER  - 

@article{
author = "Stanković, Sanja and Glišić, Sanja and Alavantić, Dragan",
year = "2000",
abstract = "To date, no data have been available on relationship between apolipoprotein E polymorphism and lipid levels in Serbian populations. Blood samples were obtained from 591 healthy normal individuals (193 women and 398 men). A 244 bp sequence of the apolipoprotein E gene including the two polymorphic sites was amplified by polymerase chain reaction. After digestion with Hhal, DNA fragments were visualized by microplate array diagonal gel electrophoresis. In men, levels of both total and low-density lipoprotein cholesterol among the three apolipoprotein E genotype groups differed significantly (p LT 0.05). The epsilon 2 allele was associated with lower concentrations of both total and low-density lipoprotein cholesterol, where the epsilon 4 allele had the opposite effects. No significant effects of apolipoprotein E polymorphism on serum lipid levels were observed in women. The presented data could be taken into consideration in any future disease risk evaluation in this population.",
journal = "Clinical Chemistry and Laboratory Medicine",
title = "The effect of a gender difference in the apolipoprotein E gene DNA polymorphism on serum lipid levels in a Serbian healthy population",
volume = "38",
number = "6",
pages = "539-544",
doi = "10.1515/CCLM.2000.079"
}

Stanković, S., Glišić, S.,& Alavantić, D.. (2000). The effect of a gender difference in the apolipoprotein E gene DNA polymorphism on serum lipid levels in a Serbian healthy population. in Clinical Chemistry and Laboratory Medicine, 38(6), 539-544.
https://doi.org/10.1515/CCLM.2000.079

Stanković S, Glišić S, Alavantić D. The effect of a gender difference in the apolipoprotein E gene DNA polymorphism on serum lipid levels in a Serbian healthy population. in Clinical Chemistry and Laboratory Medicine. 2000;38(6):539-544.
doi:10.1515/CCLM.2000.079 .

Stanković, Sanja, Glišić, Sanja, Alavantić, Dragan, "The effect of a gender difference in the apolipoprotein E gene DNA polymorphism on serum lipid levels in a Serbian healthy population" in Clinical Chemistry and Laboratory Medicine, 38, no. 6 (2000):539-544,
https://doi.org/10.1515/CCLM.2000.079 . .

TY  - JOUR
AU  - Stanković, Sanja
AU  - Glišić, Sanja
AU  - Alavantić, Dragan
PY  - 1999
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/2241
AB  - The study estimates the distribution of apoE alleles in Serbian population (622 persons) by restriction isotyping of the amplified apoE gene sequence and MADGE analysis. The E2 allele frequency estimated here (0.149) is one of the highest ever reported. A lowering in E4 frequency (0.115) compensates the increasing in E2 allele frequency. The E3 allele frequency remains comparable to Frequencies reported in other white populations. The frequency pattern of apoE alleles follows the same trend as one observed in other Caucasian European populations where the E3 allele is the most frequent (0.736). The low prevalence of E4 allele (0.114) was in agreement with underexpression of E4 in Southern Europe, compared to northern regions.
T2  - Jugoslovenska Medicinska Biohemija
T1  - Apolipoprotein E gene DNA polymorphism in Serbian population
VL  - 18
IS  - 1
SP  - 9
EP  - 15
UR  - https://hdl.handle.net/21.15107/rcub_vinar_2241
ER  - 

@article{
author = "Stanković, Sanja and Glišić, Sanja and Alavantić, Dragan",
year = "1999",
abstract = "The study estimates the distribution of apoE alleles in Serbian population (622 persons) by restriction isotyping of the amplified apoE gene sequence and MADGE analysis. The E2 allele frequency estimated here (0.149) is one of the highest ever reported. A lowering in E4 frequency (0.115) compensates the increasing in E2 allele frequency. The E3 allele frequency remains comparable to Frequencies reported in other white populations. The frequency pattern of apoE alleles follows the same trend as one observed in other Caucasian European populations where the E3 allele is the most frequent (0.736). The low prevalence of E4 allele (0.114) was in agreement with underexpression of E4 in Southern Europe, compared to northern regions.",
journal = "Jugoslovenska Medicinska Biohemija",
title = "Apolipoprotein E gene DNA polymorphism in Serbian population",
volume = "18",
number = "1",
pages = "9-15",
url = "https://hdl.handle.net/21.15107/rcub_vinar_2241"
}

Stanković, S., Glišić, S.,& Alavantić, D.. (1999). Apolipoprotein E gene DNA polymorphism in Serbian population. in Jugoslovenska Medicinska Biohemija, 18(1), 9-15.
https://hdl.handle.net/21.15107/rcub_vinar_2241

Stanković S, Glišić S, Alavantić D. Apolipoprotein E gene DNA polymorphism in Serbian population. in Jugoslovenska Medicinska Biohemija. 1999;18(1):9-15.
https://hdl.handle.net/21.15107/rcub_vinar_2241 .

Stanković, Sanja, Glišić, Sanja, Alavantić, Dragan, "Apolipoprotein E gene DNA polymorphism in Serbian population" in Jugoslovenska Medicinska Biohemija, 18, no. 1 (1999):9-15,
https://hdl.handle.net/21.15107/rcub_vinar_2241 .